Pipeline of Collaborative & Proprietary Drug Discovery Programs

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class="container-holder"> <div class="text"> <h1 class="bigger">Therapeutic Pipeline</h1><p>For more than 30 years, we have invested in advancing the science underlying our computational platform. As our technology advanced, our company evolved along with it. </p> <p>Recognizing the opportunity to leverage the full power of our platform to drive internal discovery of molecules and clinical candidates for unmet medical needs, we formed Schr枚dinger鈥檚 therapeutics group.</p> <div class="buttons "> <a href="#Proprietary-Pipeline" class="button large violet button--right"><span>View Proprietary Pipeline</span><span class="button-arrow"><svg width="16" height="16" viewBox="0 0 16 16" fill="none"><path d="M1.59961 7.9999C1.59961 7.65784 1.87146 7.38055 2.20679 7.38055L12.075 7.38055L7.44451 2.65721C7.20739 2.41534 7.20739 2.02318 7.44451 1.78131C7.68163 1.53944 8.06608 1.53944 8.3032 1.78131L14.3996 7.9999L8.3032 14.2185C8.06608 14.4604 7.68163 14.4604 7.44451 14.2185C7.20739 13.9766 7.20739 13.5845 7.44451 13.3426L12.075 8.61926L2.20679 8.61926C1.87146 8.61926 1.59961 8.34196 1.59961 7.9999Z" fill="white"></path></svg></span></a></div> </div> <div class="picture-side" style="aspect-ratio: 1024 / 967;"></div> </div> </div> <div class="picture"> <img src="https://www.schrodinger.com/wp-content/uploads/2023/11/pipeline-page-hero-3.png?w=1024" srcset="https://www.schrodinger.com/wp-content/uploads/2023/11/pipeline-page-hero-3.png 2085w, https://www.schrodinger.com/wp-content/uploads/2023/11/pipeline-page-hero-3.png?resize=300,283 300w, https://www.schrodinger.com/wp-content/uploads/2023/11/pipeline-page-hero-3.png?resize=768,725 768w, https://www.schrodinger.com/wp-content/uploads/2023/11/pipeline-page-hero-3.png?resize=1024,967 1024w, https://www.schrodinger.com/wp-content/uploads/2023/11/pipeline-page-hero-3.png?resize=1536,1451 1536w, https://www.schrodinger.com/wp-content/uploads/2023/11/pipeline-page-hero-3.png?resize=2048,1934 2048w, https://www.schrodinger.com/wp-content/uploads/2023/11/pipeline-page-hero-3.png?resize=1920,1813 1920w" alt="Therapeutic Pipeline" class="picture-img" sizes="(max-width: 1024px) 100vw, 1024px" data-no-lazy="1" loading="eager" fetchpriority="high" /> </div> </section> <div class="pipeline-info with-corners indents-internal" id="Proprietary-Pipeline"> <div class="section-bg"><img decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E" alt="Dark Background" data-lazy-src="https://www.schrodinger.com/wp-content/uploads/2023/10/pipeline-dark-bg.jpg"><noscript><img decoding="async" src="https://www.schrodinger.com/wp-content/uploads/2023/10/pipeline-dark-bg.jpg" alt="Dark Background"></noscript></div> <div class="container"> <div class="top-table indent-bottom"> <div class="section-title text-left"><h2>Proprietary Pipeline</h2></div> <div class="own-pipeline pipeline-table"> <div class="title-row"> <div class="row"> <div class="col"><span>Discovery</span></div><div class="col"><span>Preclinical</span></div><div class="col"><span>Phase 1</span></div> </div> </div> <div class="program-row "> <div class="row"> <div class="col"> <div class="content-holder"> <h5>SGR-1505 (MALT1) </h5><p>Hematologic Malignancies</p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 85%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <h5>SGR-1505 is a mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitor. </h5><p>MALT1 is a key mediator of the NF-魏B signaling pathway and the main driver of a subset of B-cell lymphomas. Ongoing, external clinical studies are showing promise of MALT1 as a potential therapeutic target for the treatment of several non-Hodgkin鈥檚 B-cell lymphomas.</p> <div class="buttons "> <a href="https://www.schrodinger.com/pipeline/malt1/" class="button large violet button--right"><span>Learn more</span><span class="button-arrow"><svg width="16" height="16" viewBox="0 0 16 16" fill="none"><path d="M1.59961 7.9999C1.59961 7.65784 1.87146 7.38055 2.20679 7.38055L12.075 7.38055L7.44451 2.65721C7.20739 2.41534 7.20739 2.02318 7.44451 1.78131C7.68163 1.53944 8.06608 1.53944 8.3032 1.78131L14.3996 7.9999L8.3032 14.2185C8.06608 14.4604 7.68163 14.4604 7.44451 14.2185C7.20739 13.9766 7.20739 13.5845 7.44451 13.3426L12.075 8.61926L2.20679 8.61926C1.87146 8.61926 1.59961 8.34196 1.59961 7.9999Z" fill="white"></path></svg></span></a></div> </div> <div class="info-img"><img decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E" alt="SGR-1505 (MALT1)" data-lazy-src="https://www.schrodinger.com/wp-content/uploads/2023/12/LS-MALT1-Pipeline-Drug-R3-1-e1701524408753.png?w=1024"><noscript><img decoding="async" src="https://www.schrodinger.com/wp-content/uploads/2023/12/LS-MALT1-Pipeline-Drug-R3-1-e1701524408753.png?w=1024" alt="SGR-1505 (MALT1)"></noscript></div> </div> </div> </div> </div> <div class="program-row "> <div class="row"> <div class="col"> <div class="content-holder"> <h5>SGR-2921 (CDC7)</h5><p>AML/MDS</p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 85%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <h5>SGR-2921 is a cell division cycle 7-related protein kinase (CDC7) inhibitor.</h5><p>CDC7 is a protein kinase that plays a critical role in cell cycle regulation and DNA replication. Elevated replication stress is a common feature of many highly proliferative cancers. External clinical studies are showing promise of CDC7 as a potential therapeutic target in oncology.</p> <div class="buttons "> <a href="https://www.schrodinger.com/pipeline/cdc7/" class="button large violet button--right"><span>Learn more</span><span class="button-arrow"><svg width="16" height="16" viewBox="0 0 16 16" fill="none"><path d="M1.59961 7.9999C1.59961 7.65784 1.87146 7.38055 2.20679 7.38055L12.075 7.38055L7.44451 2.65721C7.20739 2.41534 7.20739 2.02318 7.44451 1.78131C7.68163 1.53944 8.06608 1.53944 8.3032 1.78131L14.3996 7.9999L8.3032 14.2185C8.06608 14.4604 7.68163 14.4604 7.44451 14.2185C7.20739 13.9766 7.20739 13.5845 7.44451 13.3426L12.075 8.61926L2.20679 8.61926C1.87146 8.61926 1.59961 8.34196 1.59961 7.9999Z" fill="white"></path></svg></span></a></div> </div> <div class="info-img"><img decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E" alt="SGR-2921 (CDC7)" data-lazy-src="https://www.schrodinger.com/wp-content/uploads/2023/12/LS-CDC7-Pipeline-Drug-R3-1-e1701524458669.png?w=987"><noscript><img decoding="async" src="https://www.schrodinger.com/wp-content/uploads/2023/12/LS-CDC7-Pipeline-Drug-R3-1-e1701524458669.png?w=987" alt="SGR-2921 (CDC7)"></noscript></div> </div> </div> </div> </div> <div class="program-row "> <div class="row"> <div class="col"> <div class="content-holder"> <h5>SGR-3515 (Wee1/Myt1)</h5><p>Solid Tumors</p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 85%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <h5>SGR-3515 is a Wee1 G2 Checkpoint Kinase and Membrane Associated Tyrosine/Threonine 1 (Wee1/Myt1) inhibitor.</h5><p>Wee1 is a gatekeeper checkpoint kinase that prevents cellular progression through the cell cycle, allowing time for DNA repair before cell division takes place. Myt1 is a kinase found to be overexpressed in certain types of cancer. Concurrent loss of function of Wee1 and Myt1 confers selective vulnerability in cancer cells, a mechanism referred to as synthetic lethality. External clinical studies are showing promise of Wee1/ Myt1 inhibition as a potential therapeutic target in ovarian and uterine cancer.</p> <div class="buttons "> <a href="https://www.schrodinger.com/pipeline/wee1-myt1/" class="button large violet button--right"><span>Learn More</span><span class="button-arrow"><svg width="16" height="16" viewBox="0 0 16 16" fill="none"><path d="M1.59961 7.9999C1.59961 7.65784 1.87146 7.38055 2.20679 7.38055L12.075 7.38055L7.44451 2.65721C7.20739 2.41534 7.20739 2.02318 7.44451 1.78131C7.68163 1.53944 8.06608 1.53944 8.3032 1.78131L14.3996 7.9999L8.3032 14.2185C8.06608 14.4604 7.68163 14.4604 7.44451 14.2185C7.20739 13.9766 7.20739 13.5845 7.44451 13.3426L12.075 8.61926L2.20679 8.61926C1.87146 8.61926 1.59961 8.34196 1.59961 7.9999Z" fill="white"></path></svg></span></a></div> </div> <div class="info-img"><img decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E" alt="SGR-3515 (Wee1/Myt1)" data-lazy-src="https://www.schrodinger.com/wp-content/uploads/2023/12/LS-WEE1-Pipeline-Drug-R3-1-e1702329126212.png?w=843"><noscript><img decoding="async" src="https://www.schrodinger.com/wp-content/uploads/2023/12/LS-WEE1-Pipeline-Drug-R3-1-e1702329126212.png?w=843" alt="SGR-3515 (Wee1/Myt1)"></noscript></div> </div> </div> </div> </div> <div class="program-row "> <div class="row"> <div class="col"> <div class="content-holder"> <h5>SOS1</h5><p>Oncology</p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 50%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <p>The SOS1 protein plays a critical role in cell signaling pathways and is involved in the activation and regulation of the KRAS gene. Oncogenic mutant KRAS stimulates the growth of several cancers, such as lung, pancreatic, and colon cancer. Inhibition of SOS1 is considered a potential therapeutic strategy for the treatment of KRAS-driven cancers. </p> </div> </div> </div> </div> </div> <div class="program-row "> <div class="row"> <div class="col"> <div class="content-holder"> <h5>PRMT5-MTA</h5><p>Oncology</p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 18%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <p>PRMT5-MTA inhibition has demonstrated clinical responses in both hematologic and solid tumors with improved safety versus PRMT5 inhibitors due to a synthetic lethal targeting of cancer cells with MTAP-deletions. We have identified selective, potent PRMT5-MTA inhibitors with potential applications in solid tumors, brain metastases and primary CNS tumors.</p> </div> </div> </div> </div> </div> <div class="program-row "> <div class="row"> <div class="col"> <div class="content-holder"> <h5>EGFR<sup>C797S</sup></h5><p>Oncology</p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 18%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <p>EGFR inhibitors are first-line standard of care agents for advanced non-small cell lung cancer patients with activating EGFR mutations. We have identified multiple EGFR<sup>C797S</sup> inhibitors with potential to treat patients whose disease progressed following first-line treatment, potentially achieving deeper, more durable responses through new combination regimens.</p> </div> </div> </div> </div> </div> <div class="program-row "> <div class="row"> <div class="col"> <div class="content-holder"> <h5>NLRP3</h5><p>Immunology </p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 18%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <p>NLRP3 is a validated target, and mutations in the NLRP3 gene are associated with a broad spectrum of inflammatory and auto-immune diseases. We have identified structurally distinct, selective, NLRP3 inhibitors with anti-inflammatory activity in preclinical models, and are continuing to optimize peripheral and brain-penetrant leads.</p> </div> </div> </div> </div> </div> <div class="program-row "> <div class="row"> <div class="col"> <div class="content-holder"> <h5>LRRK2</h5><p>Neurology</p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 18%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <p>LRRK2 is a large multifunctional kinase enzyme and mutations in the LRRK2 gene have been shown to be associated with the development of Parkinson鈥檚 disease. Schr枚dinger has generated cryo-electron microscopy structures of LRRK2 to accelerate the identification of novel LRRK2 inhibitors. <br><br> Schr枚dinger received a $2.8 million research grant from The Michael J. Fox Foundation (MJFF) for Parkinson鈥檚 Research to investigate modes of safely inhibiting the LRRK2 protein for treatment of Parkinson’s disease.</p> </div> </div> </div> </div> </div> <div class="program-row blue-bg"> <div class="row"> <div class="col"> <div class="content-holder"> <h5>Undisclosed Programs</h5><p>Multiple Areas</p> </div> </div> <div class="col"> <div class="progress"> <div class="progress-title"> <span>Discovery</span><span>Preclinical</span><span>Phase 1</span> </div> <div class="progress-bar"> <div style="width: 18%" class="bar"></div> </div> </div> </div> <div class="col"> <button class="show-more-button" type="button" aria-label="Show more"> <i></i> </button> </div> </div> <div class="program-details"> <div class="program-details-holder"> <div class="info"> <div class="info-content"> <p>We are progressing a number of undisclosed programs in multiple therapeutic areas. All of these programs are currently in the discovery stage.</p> </div> </div> </div> </div> </div> </div> </div> <div class="bottom-table"> <div class="section-title text-left"> <h2>Partnered programs and collaborations</h2><p>Schr枚dinger鈥檚 therapeutics group is working on a number of collaborative drug discovery programs. We are eligible to receive milestones as certain of these programs progress through discovery and development stages, and royalties on sales for certain approved products.</p> </div> <div class="partnered-pipeline pipeline-table"> <div class="title-row"> <div class="row"> <div class="col "> <span>Partner</span> </div> <div class="col hide-mobile"> <span>Program</span><span>Therapeutic area</span> </div> <div class="col hide-mobile"> <span>Status</span> </div> <div class="col "> <span>Details</span> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Ajax Therapeutics</span> </div> <div class="col hide-mobile"> <span>JAK2</span><span>Oncology</span> </div> <div class="col hide-mobile"> <span>Preclinical</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>JAK2</span><span>Oncology</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Preclinical</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>JAK2</h5><p>Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that promotes excessive proliferation of red blood cells, white blood cells, or platelets. Mutations in the JAK2 gene are associated with several types of cancer. In collaboration with Ajax Therapeutics, Schr枚dinger is designing a JAK2 inhibitor. Schr枚dinger holds an equity stake in Ajax Therapeutics.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Bright Angel Therapeutics</span> </div> <div class="col hide-mobile"> <span>Hsp90</span><span>Antifungal</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Hsp90</span><span>Antifungal</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Hsp90</h5><p>Heat shock protein 90 (Hsp90) is a chaperone protein that plays an essential role in many cellular processes, including cell cycle control, cell survival, and hormone signaling pathways. In collaboration with Bright Angel Therapeutics, Schr枚dinger is designing an Hsp90 inhibitor. Schr枚dinger holds an equity stake in Bright Angel Therapeutics.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Bristol Myers Squibb</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>Neurology</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>Neurology</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with BMS, Schr枚dinger is progressing an undisclosed program in neurology.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Bristol Myers Squibb</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>Protein degraders</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>Protein degraders</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with BMS, Schr枚dinger is progressing an undisclosed program to discover protein degraders targeting oncology, neurology, and immunology indications.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Gilead</span> </div> <div class="col hide-mobile"> <span>ACC</span><span>NASH</span> </div> <div class="col hide-mobile"> <span>Phase 2</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>ACC</span><span>NASH</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Phase 2</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>ACC</h5><p>Acetyl-CoA carboxylase (ACC) is an enzyme involved in the synthesis of endogenous fatty acids and the breakdown of fatty acids at a cellular level. Schr枚dinger and Nimbus identified a unique series of ACC allosteric protein-protein interaction inhibitors with favorable pharmaceutical properties. Nimbus sold its ACC inhibitor program, firsocostat, to Gilead Sciences in a transaction valued at approximately $1.2 billion, and Schr枚dinger received a total of $46 million in cash distributions in 2016 and 2017.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Lilly</span> </div> <div class="col hide-mobile"> <span>伪4尾7</span><span>Inflammatory bowel diseases</span> </div> <div class="col hide-mobile"> <span>Phase 2</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>伪4尾7</span><span>Inflammatory bowel diseases</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Phase 2</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>伪<sub>4</sub>尾<sub>7</sub></h5><p>伪<sub>4</sub>尾<sub>7</sub> integrin is a well validated therapeutic target for the treatment of inflammatory bowel diseases (IBD), such as Crohn鈥檚 disease and ulcerative-colitis (UC). Schr枚dinger and Morphic discovered MORF-057, which is currently progressing through Phase 2 studies in adults with moderate to severe UC. Lilly acquired Morphic in 2024.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Lilly</span> </div> <div class="col hide-mobile"> <span>伪4尾7</span><span>GI indications</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>伪4尾7</span><span>GI indications</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Next-Gen 伪<sub>4</sub>尾<sub>7</sub></h5><p>In collaboration with Lilly, Schr枚dinger is designing a family of next-generation Next-Gen 伪<sub>4</sub>尾<sub>7</sub> inhibitors with enhanced properties.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Lilly</span> </div> <div class="col hide-mobile"> <span>伪v尾8</span><span>Solid tumors, fibrosis</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>伪v尾8</span><span>Solid tumors, fibrosis</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>伪<sub>v</sub>尾<sub>8</sub> </h5><p>伪<sub>v</sub>尾<sub>8</sub> integrin is known to activate selective isoforms of TGF-尾 and inhibit anti-tumor activity. Preclinical studies have shown that inhibiting伪 v尾8 can potentially drive responses in checkpoint refractory tumors. In collaboration with Lilly, Schr枚dinger is designing an 伪<sub>v</sub>尾<sub>8</sub> inhibitor for the treatment of solid tumors and fibrosis.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Lilly</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>Pulmonary arterial hypertension</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>Pulmonary arterial hypertension</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with Lilly, Schr枚dinger is progressing an undisclosed program for evaluation as a potential treatment for pulmonary arterial hypertension.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Lilly</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>Immunology</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>Immunology</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with Lilly, Schr枚dinger is progressing an undisclosed program in immunology. Under the terms of the agreement, Schr枚dinger received an upfront payment and is eligible to receive up to $425 million in discovery, development, and commercial milestone payments, as well as low single- to low double-digit royalties on net sales of any products emerging from the collaboration in all markets.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Nimbus Therapeutics</span> </div> <div class="col hide-mobile"> <span>HPK1</span><span>Immuno-oncology</span> </div> <div class="col hide-mobile"> <span>Phase 1/2</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>HPK1</span><span>Immuno-oncology</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Phase 1/2</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>HPK1</h5><p>Hematopoietic progenitor kinase 1 (HPK1) is an intracellular negative regulator of T cell proliferation and signaling and dendritic cell activation. Schr枚dinger and Nimbus identified an HPK1 inhibitor that is currently being evaluated for safety, tolerability, and preliminary anti-tumor activity in a Phase 1/2 clinical trial for patients with solid tumors.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Novartis</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>Undisclosed</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>Undisclosed</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with Novartis, Schr枚dinger is progressing multiple undisclosed programs currently in discovery.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Otsuka</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>CNS</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>CNS</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In December 2022, Schr枚dinger and Otsuka initiated a collaboration to discover novel medicines against undisclosed central nervous system (CNS) targets. Schr枚dinger received an undisclosed upfront milestone payment and is eligible for additional milestones as the program progresses.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Structure Therapeutics</span> </div> <div class="col hide-mobile"> <span>APJR</span><span>Pulmonary arterial hypertension</span> </div> <div class="col hide-mobile"> <span>Phase 1</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>APJR</span><span>Pulmonary arterial hypertension</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Phase 1</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>APJR</h5><p>Apelin receptor (APJR) is a class A peptide binding G protein-coupled receptor that plays an important role in regulating blood pressure, cardiac output, and maintenance of fluid homeostasis. Schr枚dinger and Structure Therapeutics discovered an oral APJR agonist, ANPA-0073, which is currently being evaluated in a Phase 1 clinical study for the potential treatment of pulmonary arterial hypertension and idiopathic pulmonary fibrosis. Schr枚dinger holds an equity stake in Structure.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Structure Therapeutics</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>Undisclosed</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>Undisclosed</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with Structure, Schr枚dinger is progressing an undisclosed program currently in discovery.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Structure Therapeutics</span> </div> <div class="col hide-mobile"> <span>LPA1R</span><span>Idiopathic pulmonary fibrosis</span> </div> <div class="col hide-mobile"> <span>Preclinical</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>LPA1R</span><span>Idiopathic pulmonary fibrosis</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Preclinical</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>LPA1R</h5><p>Lysophosphatidic acid receptor 1 (LPA1R) regulates enteric nervous system function and contributes to chronic intestinal pseudo-obstruction. Increased LPA levels and activation of LPA1 have been implicated in pulmonary fibrosis. Schr枚dinger and Structure discovered an oral LPA1R agonist, LTSE-2578, which is currently in preclinical development for the potential treatment of idiopathic pulmonary fibrosis.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Takeda</span> </div> <div class="col hide-mobile"> <span>TYK2</span><span>Psoriasis</span> </div> <div class="col hide-mobile"> <span>Phase 3</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>TYK2</span><span>Psoriasis</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Phase 3</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>TYK2</h5><p><strong>TAK-279 is a non-receptor tyrosine-protein kinase (TYK2) inhibitor</strong><br><br> TYK2 is a key mediator of cytokine signaling pathways implicated in multiple inflammatory and autoimmune diseases such as psoriasis, rheumatoid arthritis, lupus, and inflammatory bowel diseases. Schr枚dinger and Nimbus discovered the TYK2 inhibitor TAK-279 (formerly NDI-034858), which was acquired by Takeda in 2023 and is currently being evaluated for the treatment of multiple autoimmune diseases following positive Phase 2b results in psoriasis. Schr枚dinger maintains an equity stake in Nimbus and received a $111.3 million cash distribution in connection with Takeda’s acquisition of TAK-279.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Takeda</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>Oncology</span> </div> <div class="col hide-mobile"> <span>Discovery</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>Oncology</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Discovery</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with Takeda, Schr枚dinger is advancing an undisclosed program in oncology. Under this multi-year, multi-target collaboration, Schr枚dinger conducts all drug discovery research and pharmacology activities through the development candidate stage, and Takeda has the option to acquire the program at either the lead optimization stage or development candidate stage and to develop and commercialize such product candidate from the program.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Undisclosed</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>CNS</span> </div> <div class="col hide-mobile"> <span>Phase 1</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>CNS</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Phase 1</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with an undisclosed company, Schr枚dinger is advancing an undisclosed CNS program, which is currently progressing through a Phase 1 clinical study.</p> </div> </div> </div> </div> <div class="program-row"> <div class="row"> <div class="col"> <span>Undisclosed</span> </div> <div class="col hide-mobile"> <span>Undisclosed</span><span>Oncology</span> </div> <div class="col hide-mobile"> <span>Phase 1</span> </div> <div class="col"> <button class="show-more-button" aria-label="Next" type="button"> <i></i> </button> </div> </div> <div class="program-details"> <div class="hide-desktop"> <div class="program-detail-block"> <div class="title"> <span>Program</span><span>Therapeutic area</span> </div> <div class="value"> <span>Undisclosed</span><span>Oncology</span> </div> </div> <div class="program-detail-block"> <div class="title"> <span>Status</span> </div> <div class="value"> <span>Phase 1</span> </div> </div> </div> <div class="info"> <div class="info-content"> <h5>Undisclosed</h5><p>In collaboration with an undisclosed company, Schr枚dinger is advancing an undisclosed program in oncology, which is currently progressing through a Phase 1 clinical study.</p> </div> </div> </div> </div> </div> </div> <p class="disclaimer"><br>Additionally, an early collaboration with Agios resulted in two FDA-approved medications, Idhifa庐 and Tibsovo庐.</p> </div> </div> <section class="benefits-section oposite indent-bottom indents-internal-top" > <div class="container"> <div class="reverse-row "> <div class="picture"> <img decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E" alt="Our therapeutics team" 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