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Synaptic Activities by Nicotinic Acetylcholine Receptors</h1> </header> <div class="entry-thumbnail"> <img width="260" height="146" src="https://jaddictionscience.com/wp-content/uploads/sites/11/2018/10/jrdsas-018-hiroki-toyoda.jpg" class="attachment-content-single wp-post-image" alt="jrdsas-018-hiroki-toyoda"/></div> <p class="entry-meta"> </p> <div class="entry-content clearfix"> <div class="italics"><i>Hiroki Toyoda</i></div> <div class="italics"></div> <div class="italics"></div> <div></div> <p> </p> <div> <p><strong>Abstract</strong></p> </div> <p>It has been evident that the insular cortex (IC) is involved in formation of nicotine addiction. However, its neural mechanisms remain largely unclear. Therefore, we have recently investigated how activation of nicotinic acetylcholine receptors (nAChRs) affects synaptic activities such as synaptic transmission and plasticity in layer 3, 5 and 6 (L3, L5 and L6, respectively) pyramidal cells (PCs) of the IC in mice. Furthermore, we investigated which cell types have functional nicotinic receptors in L3, L5 and L6 of the IC. We have found that activation<br/> of nicotinic receptors layer-dependently modulates synaptic transmission and plasticity in L3, L5 and L6 PCs of the mouse IC. In this short review, I describe our experimental evidence which may contribute to neuronal mechanisms for addiction to tobacco smoking.</p> <div><strong>Published on:</strong> October 29, 2018<br/> <strong>doi:</strong> 10.17756/jrdsas.2018-041<br/> <strong>Citation:</strong> Toyoda H. 2018. Layer-Dependent Modulation of Mouse Insular Synaptic Activities by Nicotinic Acetylcholine Receptors. <i>J Reward Defic Syndr Addict Sci</i> 4(1): 9-12.</div> <div class="italics"> </div> <div class="pdfdownloadlink"><img class="alignleft size-full wp-image-507" style="margin: 4px -5px 4px 5px;" src="http://jnanoworld.com/wp-content/uploads/2017/04/pdf-icon-24-e1509106685135-1.png" alt="" width="16" height="16"/><div class="sdm_download_link"><a href="https://jaddictionscience.com/?smd_process_download=1&download_id=413" class="sdm_download green" title="jrdsas-018-hiroki-toyoda" target="_self">PDF (Download Full text)</a></div></div> <div><div class="sdm_download_count"><span class="sdm_count_number"><strong>767</strong></span><br/><span class="sdm_count_string"> Downloads</span></div><span class="postviews_eachpost"><div class="post-views post-111 entry-meta"> <span class="post-views-label">Views </span> <span class="post-views-count">1,623</span> </div></span></div> <script type="text/javascript">jQuery(document).ready(function($){$.post('https://jaddictionscience.com/wp-admin/admin-ajax.php',{action:'wpt_view_count',id:'111'});});</script><div class="addtoany_share_save_container addtoany_content_bottom"><div class="a2a_kit a2a_kit_size_32 addtoany_list" data-a2a-url="https://jaddictionscience.com/2018/10/29/layer-dependent-modulation-of-mouse-insular-synaptic-activities-by-nicotinic-acetylcholine-receptors/" data-a2a-title="Layer-Dependent Modulation of Mouse Insular Synaptic Activities by Nicotinic Acetylcholine Receptors"><a class="a2a_button_facebook" href="https://www.addtoany.com/add_to/facebook?linkurl=https%3A%2F%2Fjaddictionscience.com%2F2018%2F10%2F29%2Flayer-dependent-modulation-of-mouse-insular-synaptic-activities-by-nicotinic-acetylcholine-receptors%2F&linkname=Layer-Dependent%20Modulation%20of%20Mouse%20Insular%20Synaptic%20Activities%20by%20Nicotinic%20Acetylcholine%20Receptors" title="Facebook" rel="nofollow noopener" target="_blank"></a><a class="a2a_button_twitter" href="https://www.addtoany.com/add_to/twitter?linkurl=https%3A%2F%2Fjaddictionscience.com%2F2018%2F10%2F29%2Flayer-dependent-modulation-of-mouse-insular-synaptic-activities-by-nicotinic-acetylcholine-receptors%2F&linkname=Layer-Dependent%20Modulation%20of%20Mouse%20Insular%20Synaptic%20Activities%20by%20Nicotinic%20Acetylcholine%20Receptors" title="Twitter" rel="nofollow noopener" target="_blank"></a><a class="a2a_button_google_plus" href="https://www.addtoany.com/add_to/google_plus?linkurl=https%3A%2F%2Fjaddictionscience.com%2F2018%2F10%2F29%2Flayer-dependent-modulation-of-mouse-insular-synaptic-activities-by-nicotinic-acetylcholine-receptors%2F&linkname=Layer-Dependent%20Modulation%20of%20Mouse%20Insular%20Synaptic%20Activities%20by%20Nicotinic%20Acetylcholine%20Receptors" title="Google+" rel="nofollow noopener" target="_blank"></a><a class="a2a_dd addtoany_share_save" href="https://www.addtoany.com/share"></a></div></div> </div> </article> </div> <aside class="mh-sidebar"> <div id="search-2" class="sb-widget clearfix widget_search"><form role="search" method="get" class="search-form" action="https://jaddictionscience.com/"> <label> <span class="screen-reader-text">Search for:</span> <input type="search" class="search-field" placeholder="Search …" value="" name="s" title="Search for:"/> </label> <input type="submit" class="search-submit" value="Search"/> </form></div><div id="category-posts-2" class="sb-widget clearfix cat-post-widget"><h4 class="widget-title"><span><a href="">Popular Articles</a></span></h4><ul id="category-posts-2-internal" class="category-posts-internal"> <li class='cat-post-item'><a class="post-title cat-post-title" href="https://jaddictionscience.com/2024/07/10/addiction-co-occurring-with-autism-spectrum-disorder/" rel="bookmark">Addiction Co-occurring with Autism Spectrum Disorder</a> </li><li class='cat-post-item'><a class="post-title cat-post-title" href="https://jaddictionscience.com/2024/05/10/language-matters-a-critical-discourse-analysis-of-how-substance-use-disorders-are-portrayed-in-a-primary-care-journal-over-the-last-20-years/" rel="bookmark">Language Matters: A Critical Discourse Analysis of How Substance Use Disorders are Portrayed in a Primary Care Journal Over the Last 20 Years</a> </li><li class='cat-post-item'><a class="post-title cat-post-title" href="https://jaddictionscience.com/2024/04/02/understanding-the-balancing-students-juggling-work-and-studies-the-digital-dilemma-phone-usage-among-students/" rel="bookmark">Understanding the Balancing: Students Juggling Work and Studies. 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