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Flavivirussen - Wikipedia
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mw-first-heading"><span class="mw-page-title-main">Flavivirussen</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Ga naar een artikel in een andere taal. Beschikbaar in 28 talen" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-28" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">28 talen</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%81%D9%8A%D8%B1%D9%88%D8%B3%D8%A7%D8%AA_%D9%85%D8%B5%D9%81%D8%B1%D8%A9" title="فيروسات مصفرة – Arabisch" lang="ar" hreflang="ar" data-title="فيروسات مصفرة" data-language-autonym="العربية" data-language-local-name="Arabisch" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/%D9%81%D9%8A%D8%B1%D9%88%D8%B3%D8%A7%D8%AA_%D9%85%D8%B5%D9%81%D8%B1%D9%87" title="فيروسات مصفره – Egyptisch Arabisch" lang="arz" hreflang="arz" data-title="فيروسات مصفره" data-language-autonym="مصرى" data-language-local-name="Egyptisch Arabisch" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%A4%D0%BB%D0%B0%D0%B2%D0%B8%D0%B2%D0%B8%D1%80%D1%83%D1%81%D0%B8" title="Флавивируси – Bulgaars" lang="bg" hreflang="bg" data-title="Флавивируси" data-language-autonym="Български" data-language-local-name="Bulgaars" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Catalaans" lang="ca" hreflang="ca" data-title="Flaviviridae" data-language-autonym="Català" data-language-local-name="Catalaans" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Tsjechisch" lang="cs" hreflang="cs" data-title="Flaviviridae" data-language-autonym="Čeština" data-language-local-name="Tsjechisch" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Duits" lang="de" hreflang="de" data-title="Flaviviridae" data-language-autonym="Deutsch" data-language-local-name="Duits" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Engels" lang="en" hreflang="en" data-title="Flaviviridae" data-language-autonym="English" data-language-local-name="Engels" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Spaans" lang="es" hreflang="es" data-title="Flaviviridae" data-language-autonym="Español" data-language-local-name="Spaans" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Estisch" lang="et" hreflang="et" data-title="Flaviviridae" data-language-autonym="Eesti" data-language-local-name="Estisch" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Frans" lang="fr" hreflang="fr" data-title="Flaviviridae" data-language-autonym="Français" data-language-local-name="Frans" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-frr mw-list-item"><a href="https://frr.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Noord-Fries" lang="frr" hreflang="frr" data-title="Flaviviridae" data-language-autonym="Nordfriisk" data-language-local-name="Noord-Fries" class="interlanguage-link-target"><span>Nordfriisk</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A4%D7%9C%D7%90%D7%95%D7%95%D7%99%D7%95%D7%95%D7%99%D7%A8%D7%99%D7%93%D7%94" title="פלאוויווירידה – Hebreeuws" lang="he" hreflang="he" data-title="פלאוויווירידה" data-language-autonym="עברית" data-language-local-name="Hebreeuws" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Kroatisch" lang="hr" hreflang="hr" data-title="Flaviviridae" data-language-autonym="Hrvatski" data-language-local-name="Kroatisch" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Armeens" lang="hy" hreflang="hy" data-title="Flaviviridae" data-language-autonym="Հայերեն" data-language-local-name="Armeens" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-ia mw-list-item"><a href="https://ia.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Interlingua" lang="ia" hreflang="ia" data-title="Flaviviridae" data-language-autonym="Interlingua" data-language-local-name="Interlingua" class="interlanguage-link-target"><span>Interlingua</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Indonesisch" lang="id" hreflang="id" data-title="Flaviviridae" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesisch" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Italiaans" lang="it" hreflang="it" data-title="Flaviviridae" data-language-autonym="Italiano" data-language-local-name="Italiaans" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%95%E3%83%A9%E3%83%93%E3%82%A6%E3%82%A4%E3%83%AB%E3%82%B9%E7%A7%91" title="フラビウイルス科 – Japans" lang="ja" hreflang="ja" data-title="フラビウイルス科" data-language-autonym="日本語" data-language-local-name="Japans" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Latijn" lang="la" hreflang="la" data-title="Flaviviridae" data-language-autonym="Latina" data-language-local-name="Latijn" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Maleis" lang="ms" hreflang="ms" data-title="Flaviviridae" data-language-autonym="Bahasa Melayu" data-language-local-name="Maleis" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Noors - Bokmål" lang="nb" hreflang="nb" data-title="Flaviviridae" data-language-autonym="Norsk bokmål" data-language-local-name="Noors - Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Flawiwirusy" title="Flawiwirusy – Pools" lang="pl" hreflang="pl" data-title="Flawiwirusy" data-language-autonym="Polski" data-language-local-name="Pools" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Portugees" lang="pt" hreflang="pt" data-title="Flaviviridae" data-language-autonym="Português" data-language-local-name="Portugees" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Flaviviride" title="Flaviviride – Roemeens" lang="ro" hreflang="ro" data-title="Flaviviride" data-language-autonym="Română" data-language-local-name="Roemeens" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Russisch" lang="ru" hreflang="ru" data-title="Flaviviridae" data-language-autonym="Русский" data-language-local-name="Russisch" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Servo-Kroatisch" lang="sh" hreflang="sh" data-title="Flaviviridae" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Servo-Kroatisch" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Flaviviridae" title="Flaviviridae – Simple English" lang="en-simple" hreflang="en-simple" data-title="Flaviviridae" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a 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class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Uit Wikipedia, de vrije encyclopedie</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="nl" dir="ltr"><table class="infobox" cellpadding="1" cellspacing="1" style="font-size:95%;"> <tbody><tr> <th class="infobox-kop notheme" style="background-color:#dae1e2; color:inherit; font-weight:bold;"><big>Flavivirussen</big> </th></tr> <tr> <td style="text-align:center; padding:0;"><span typeof="mw:File"><a href="/wiki/Bestand:YellowFeverVirus.jpg" class="mw-file-description"><img alt="Flavivirussen" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/YellowFeverVirus.jpg/266px-YellowFeverVirus.jpg" decoding="async" width="266" height="315" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/YellowFeverVirus.jpg/399px-YellowFeverVirus.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/45/YellowFeverVirus.jpg/532px-YellowFeverVirus.jpg 2x" data-file-width="2328" data-file-height="2760" /></a></span> </td></tr> <tr> <th class="infobox-kop notheme" style="background-color: #dae1e2; color:inherit; font-weight:bold;"><a href="/wiki/Taxonomie_(biologie)" title="Taxonomie (biologie)">Taxonomische indeling</a> </th></tr> <tr> <td> <table style="margin:0 auto;"> <tbody><tr><td class="vatop">(Geen rang):</td><td class="vatop"><a href="/wiki/Virus_(biologie)" title="Virus (biologie)">Virussen</a></td></tr><tr><td class="vatop"><a href="/wiki/Imperium_(virologie)" title="Imperium (virologie)">Imperium</a>:</td><td class="vatop"><a href="/wiki/Riboviria" title="Riboviria">Riboviria</a></td></tr><tr><td><a href="/wiki/Baltimore-classificatie" title="Baltimore-classificatie">Groep</a>:</td><td>Groep IV <small>(<a href="/wiki/Positief_enkelstrengig_RNA-virus" class="mw-redirect" title="Positief enkelstrengig RNA-virus">(+)ssRNA</a>)</small> </td></tr><tr><td></td></tr></tbody></table> </td></tr> <tr> <th class="infobox-kop notheme" style="background-color: #dae1e2; color:inherit; font-weight:bold;"><a href="/wiki/Familie_(biologie)" title="Familie (biologie)">Familie</a> </th></tr> <tr> <td class="ta-center"><b>Flaviviridae</b><br /> </td></tr> <tr> <th class="infobox-kop notheme" style="background-color: #dae1e2; color:inherit; font-weight:bold;" colspan="2"> </th></tr> <tr> <td class="ta-center" colspan="2"><small><a href="https://commons.wikimedia.org/wiki/Category:Flaviviridae" class="extiw" title="commons:Category:Flaviviridae">Afbeeldingen</a> op</small> <span class="noviewer" typeof="mw:File"><a href="/wiki/Bestand:Commons-logo.svg" class="mw-file-description" title="Wikimedia Commons"><img alt="Wikimedia Commons" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/15px-Commons-logo.svg.png" decoding="async" width="15" height="20" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/23px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/30px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <small><a href="/wiki/Wikimedia_Commons" title="Wikimedia Commons">Wikimedia Commons</a></small> </td></tr> <tr> <td class="ta-center" colspan="2"><small><a href="https://species.wikimedia.org/wiki/Flaviviridae" class="extiw" title="wikispecies:Flaviviridae">Flavivirussen</a> op</small> <span class="noviewer" typeof="mw:File"><a href="/wiki/Bestand:Wikispecies-logo.svg" class="mw-file-description" title="Wikispecies"><img alt="Wikispecies" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/df/Wikispecies-logo.svg/15px-Wikispecies-logo.svg.png" decoding="async" width="15" height="18" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/df/Wikispecies-logo.svg/23px-Wikispecies-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/df/Wikispecies-logo.svg/30px-Wikispecies-logo.svg.png 2x" data-file-width="941" data-file-height="1103" /></a></span> <small><a href="/wiki/Wikispecies" title="Wikispecies">Wikispecies</a></small> </td></tr> <tr> <td class="ta-center" colspan="2"><style data-mw-deduplicate="TemplateStyles:r67679320">.mw-parser-output .taalaanduiding{font-family:sans-serif;font-size:85%;cursor:help;color:var(--color-subtle,#555)}.mw-parser-output .taalaanduiding span{border-bottom:1px dotted var(--color-subtle,#555)}</style><span class="taalaanduiding" title="Taal: Engels">(<span>en</span>) </span> <small> <a rel="nofollow" class="external text" href="https://www.marinespecies.org/aphia.php?p=taxdetails&id=600097">World Register of Marine Species</a></small> </td></tr> <tr> <th class="infobox-kop notheme" style="background-color: #dae1e2; color:inherit;" colspan="2"> <table style="margin:0 auto;" cellspacing="0" cellpadding="0"> <tbody><tr> <td style="vertical-align:middle;"><b>Portaal</b>  <span class="noviewer" typeof="mw:File"><a href="/wiki/Bestand:Portal.svg" class="mw-file-description" title="Portaalicoon"><img alt="Portaalicoon" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/22px-Portal.svg.png" decoding="async" width="22" height="20" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/33px-Portal.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/44px-Portal.svg.png 2x" data-file-width="36" data-file-height="32" /></a></span>   </td> <td class="ta-left"><b><a href="/wiki/Portaal:Biologie" title="Portaal:Biologie">Biologie</a> </b> </td></tr></tbody></table> </th></tr></tbody></table> <p><b>Flavivirussen</b> (<i>Flaviviridae</i>) vormen een <a href="/wiki/Familie_(biologie)" title="Familie (biologie)">familie</a> van <a href="/wiki/Positief_enkelstrengs_RNA-virus" title="Positief enkelstrengs RNA-virus">positief enkelstrengse RNA-virussen</a>, die voornamelijk zoogdieren en vogels infecteren. Ze worden verspreid door <a href="/wiki/Muggen" title="Muggen">muggen</a>, <a href="/wiki/Teken_(dieren)" title="Teken (dieren)">teken</a> en andere geleedpotigen die het virus bij zich dragen. Samen met andere virusfamilies die door geleedpotigen worden verspreid vormen ze de zogenaamde <a href="/wiki/Arbovirussen" title="Arbovirussen">arbovirussen</a>. </p><p>Het woord <i>Flaviviridae</i> is afkomstig van het <a href="/wiki/Latijn" title="Latijn">Latijn</a> flavus (geel). Virussen uit deze familie staan bekend om het feit dat ze <a href="/wiki/Gele_koorts" title="Gele koorts">gele koorts</a> veroorzaken. Er zijn ongeveer negentig soorten bekend, verdeeld over vier geslachten. Ziekten die verband houden met de flavivirussen, zijn onder meer <a href="/wiki/Hepatitis" class="mw-redirect" title="Hepatitis">hepatitis</a> (hepacivirus), hemorragische syndromen, <a href="/wiki/Boviene_virale_diarree" title="Boviene virale diarree">mucosale ziekten</a> (pestivirussen), <a href="/wiki/Encefalitis" class="mw-redirect" title="Encefalitis">encefalitis</a> en de aangeboren aandoening <a href="/wiki/Microcefalie" title="Microcefalie">microcefalie</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Genoom">Genoom</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flavivirussen&veaction=edit&section=1" title="Bewerk dit kopje: Genoom" class="mw-editsection-visualeditor"><span>bewerken</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Flavivirussen&action=edit&section=1" title="De broncode bewerken van de sectie: Genoom"><span>brontekst bewerken</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Virussen binnen de familie <i>Flaviviridae</i> hebben lineaire, <a href="/wiki/Positief_enkelstrengs_RNA-virus" title="Positief enkelstrengs RNA-virus">enkelstrengse RNA-genomen</a> met een positieve polariteit. De totale genoomgrootte varieert tussen de 9,6 tot 12,3 duizend nucleotiden. Aan het 5'-eind van het genoom bevindt zich meestal een <a href="/wiki/Methylering" title="Methylering">gemethyleerde</a> <a href="/wiki/5%27-cap" title="5'-cap">cap</a>. Bij sommige geslachten is deze cap afwezig, en codeert het virus in plaats daarvan voor een interne ribosoomtoegangsplaats. </p> <div class="mw-heading mw-heading2"><h2 id="Taxonomie">Taxonomie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flavivirussen&veaction=edit&section=2" title="Bewerk dit kopje: Taxonomie" class="mw-editsection-visualeditor"><span>bewerken</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Flavivirussen&action=edit&section=2" title="De broncode bewerken van de sectie: Taxonomie"><span>brontekst bewerken</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Er zijn vier <a href="/wiki/Geslacht_(biologie)" title="Geslacht (biologie)">geslachten</a> binnen de familie: </p> <ul><li><a href="/wiki/Flavivirus" class="mw-redirect" title="Flavivirus">Flavivirus</a>: meer dan 70 onderverdeeld in 9 groepen, onder andere <a href="/wiki/Gele-koortsvirus" title="Gele-koortsvirus">gelekoortsvirus</a>, <a href="/wiki/Denguevirus" title="Denguevirus">denguevirus</a> en <a href="/wiki/Zikavirus" title="Zikavirus">zikavirus</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li><a href="/w/index.php?title=Pestivirus&action=edit&redlink=1" class="new" title="Pestivirus (de pagina bestaat niet)">Pestivirus</a>: <a href="/wiki/Boviene_virus_diarree" class="mw-redirect" title="Boviene virus diarree">Boviene virus diarree</a>-virus (BVD, bij rundvee), het <a href="/wiki/Varkenspest" class="mw-redirect" title="Varkenspest">varkenspestvirus</a> (bij varkens) en het <a href="/w/index.php?title=Border_disease_virus&action=edit&redlink=1" class="new" title="Border disease virus (de pagina bestaat niet)">border disease virus</a> (BDV, bij schapen).</li> <li><a href="/w/index.php?title=Hepacivirus&action=edit&redlink=1" class="new" title="Hepacivirus (de pagina bestaat niet)">Hepacivirus</a>: <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a> virus en <a href="/w/index.php?title=Hepatitis_G&action=edit&redlink=1" class="new" title="Hepatitis G (de pagina bestaat niet)">hepatitis G</a> virus, GB virus A</li> <li><a href="/w/index.php?title=Pegivirus&action=edit&redlink=1" class="new" title="Pegivirus (de pagina bestaat niet)">Pegivirus</a>: GB virus C</li></ul> <div class="mw-heading mw-heading2"><h2 id="Virologie">Virologie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Flavivirussen&veaction=edit&section=3" title="Bewerk dit kopje: Virologie" class="mw-editsection-visualeditor"><span>bewerken</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Flavivirussen&action=edit&section=3" title="De broncode bewerken van de sectie: Virologie"><span>brontekst bewerken</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>Flavivirussen</i> zijn <a href="/wiki/Positief_enkelstrengig_RNA-virus" class="mw-redirect" title="Positief enkelstrengig RNA-virus">positief enkelstrengige RNA-virussen</a> met een <a href="/wiki/Genoom" title="Genoom">genoom</a> van gemiddeld zo'n 10.000 <a href="/wiki/Nucleotide" title="Nucleotide">nucleotiden</a> lang. Het genoom heeft een karakteristieke opbouw met achtereenvolgens: </p> <ul><li>5'UTR (UnTranslated Region) met IRES (Internal Ribosome Entry Site)-sequentie</li> <li>C (core proteïne, complexed with the genome)</li> <li>E1 (eerste enveloppe-proteïne)</li> <li>E2 (tweede enveloppe-proteïne)</li> <li>p7 / NS2 (niet-structurele proteïne)</li> <li>NS3</li> <li>NS4A</li> <li>NS4B</li> <li>NS5A</li> <li>NS5B (RNA-dep. RNA polymerase)</li> <li>3'UTR</li></ul> <p><a href="/wiki/Replicatie_(DNA)" title="Replicatie (DNA)">Replicatie</a> gebeurt door de productie van enkele <a href="/w/index.php?title=Negative_stranded&action=edit&redlink=1" class="new" title="Negative stranded (de pagina bestaat niet)">negative stranded</a> intermediairen, vanwaar dan de positive stranded genomen kunnen worden gekopieerd. Transmissie vindt <a href="/wiki/Parenteraal" title="Parenteraal">parenteraal</a> plaats, wat voor de mens neerkomt op <a href="/wiki/Steekmuggen" title="Steekmuggen">muggenbeten</a>, o.a. door <a href="/wiki/Aedes_aegypti" class="mw-redirect" title="Aedes aegypti">Aedes aegypti</a> en <a href="/wiki/Aedes_albopictus" class="mw-redirect" title="Aedes albopictus">Aedes albopictus</a>, <a href="/wiki/Bloedtransfusie" title="Bloedtransfusie">bloedtransfusies</a>, <a href="/wiki/Intraveneus" title="Intraveneus">intraveneus</a> en transmissie van moeder op kind tijdens een zwangerschap. </p> <div class="toccolours appendix" role="presentation" style="font-size:90%; margin:1em 0 -0.5em; clear:both;"> <div><span style="font-weight:bold">Bronnen, noten en/of referenties</span></div> <div class="reflist" style="list-style-type: decimal;"><div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20151225051517/http://www.cdc.gov/zika/hc-providers/clinicalevaluation.html">CDC</a></span> </li> </ol></div></div> </div> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐7c479b968‐xctst Cached time: 20241117114318 Cache expiry: 2592000 Reduced expiry: false Complications: [] CPU time usage: 0.091 seconds Real time usage: 0.194 seconds Preprocessor visited node count: 782/1000000 Post‐expand include size: 7959/2097152 bytes Template argument size: 576/2097152 bytes Highest expansion depth: 10/100 Expensive parser function count: 0/500 Unstrip recursion depth: 0/20 Unstrip post‐expand size: 815/5000000 bytes Lua time usage: 0.023/10.000 seconds Lua memory usage: 1374082/52428800 bytes Number of Wikibase entities loaded: 1/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 161.034 1 -total 91.79% 147.815 1 Sjabloon:Taxobox_virus 89.87% 144.726 1 Sjabloon:Taxobox 9.42% 15.174 1 Sjabloon:En 7.02% 11.307 1 Sjabloon:Appendix 6.00% 9.655 1 Sjabloon:Wikidata_afbeelding 5.55% 8.942 1 Sjabloon:Taalaanduiding 4.97% 7.999 1 Sjabloon:References 1.17% 1.878 5 Sjabloon:Hekje --> <!-- Saved in parser cache with key nlwiki:pcache:idhash:85428-0!canonical and timestamp 20241117114318 and revision id 66290250. 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