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vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Utilisation_/_Posologie"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Utilisation / Posologie</span> </div> </a> <ul id="toc-Utilisation_/_Posologie-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Effets_secondaires" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Effets_secondaires"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Effets secondaires</span> </div> </a> <ul id="toc-Effets_secondaires-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Contre-indications" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Contre-indications"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Contre-indications</span> </div> </a> <button aria-controls="toc-Contre-indications-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Contre-indications</span> </button> <ul id="toc-Contre-indications-sublist" class="vector-toc-list"> <li id="toc-Contre-indications_relatives" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Contre-indications_relatives"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Contre-indications relatives</span> </div> </a> <ul id="toc-Contre-indications_relatives-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Contre-indications_absolues" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Contre-indications_absolues"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Contre-indications absolues</span> </div> </a> <ul id="toc-Contre-indications_absolues-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Interactions_médicamenteuses" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions_médicamenteuses"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Interactions médicamenteuses</span> </div> </a> <ul id="toc-Interactions_médicamenteuses-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Antagonisation" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Antagonisation"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Antagonisation</span> </div> </a> <ul id="toc-Antagonisation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Références" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Références"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Références</span> </div> </a> <ul id="toc-Références-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sommaire" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Basculer la table des matières" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Basculer la table des matières</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Médétomidine</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Aller à un article dans une autre langue. Disponible en 12 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-12" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">12 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Medetomidin" title="Medetomidin – allemand" lang="de" hreflang="de" data-title="Medetomidin" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Medetomidine" title="Medetomidine – anglais" lang="en" hreflang="en" data-title="Medetomidine" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%85%D8%AF%D8%AA%D9%88%D9%85%DB%8C%D8%AF%DB%8C%D9%86" title="مدتومیدین – persan" lang="fa" hreflang="fa" data-title="مدتومیدین" data-language-autonym="فارسی" data-language-local-name="persan" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Medetomidiini" title="Medetomidiini – finnois" lang="fi" hreflang="fi" data-title="Medetomidiini" data-language-autonym="Suomi" data-language-local-name="finnois" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Medetomidina" title="Medetomidina – italien" lang="it" hreflang="it" data-title="Medetomidina" data-language-autonym="Italiano" data-language-local-name="italien" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%A1%E3%83%87%E3%83%88%E3%83%9F%E3%82%B8%E3%83%B3" title="メデトミジン – japonais" lang="ja" hreflang="ja" data-title="メデトミジン" data-language-autonym="日本語" data-language-local-name="japonais" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Medetomidine" title="Medetomidine – néerlandais" lang="nl" hreflang="nl" data-title="Medetomidine" data-language-autonym="Nederlands" data-language-local-name="néerlandais" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Medetomidyna" title="Medetomidyna – polonais" lang="pl" hreflang="pl" data-title="Medetomidyna" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Medetomidin%C4%83" title="Medetomidină – roumain" lang="ro" hreflang="ro" data-title="Medetomidină" data-language-autonym="Română" data-language-local-name="roumain" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Medetomidin" title="Medetomidin – serbo-croate" lang="sh" hreflang="sh" data-title="Medetomidin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croate" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Medetomidin" title="Medetomidin – serbe" lang="sr" hreflang="sr" data-title="Medetomidin" data-language-autonym="Српски / srpski" data-language-local-name="serbe" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Medetomidine" title="Medetomidine – vietnamien" lang="vi" hreflang="vi" data-title="Medetomidine" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamien" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q427179#sitelinks-wikipedia" title="Modifier les liens interlangues" class="wbc-editpage">Modifier les liens</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div 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href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit" title="Modifier cette page [v]" accesskey="v"><span>Modifier</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit" title="Modifier le wikicode de cette page [e]" accesskey="e"><span>Modifier le code</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=history" title="Historique des versions de cette page [h]" accesskey="h"><span>Voir l’historique</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Outils de la page"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Outils" > 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data-event-name="pinnable-header.vector-page-tools.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">masquer</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Plus d’options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/M%C3%A9d%C3%A9tomidine"><span>Lire</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit" title="Modifier cette page [v]" accesskey="v"><span>Modifier</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit" title="Modifier le wikicode de cette page [e]" accesskey="e"><span>Modifier le code</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=history"><span>Voir l’historique</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Général </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Sp%C3%A9cial:Pages_li%C3%A9es/M%C3%A9d%C3%A9tomidine" title="Liste des pages liées qui pointent sur celle-ci [j]" accesskey="j"><span>Pages liées</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Sp%C3%A9cial:Suivi_des_liens/M%C3%A9d%C3%A9tomidine" rel="nofollow" title="Liste des modifications récentes des pages appelées par celle-ci [k]" accesskey="k"><span>Suivi des pages liées</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Aide:Importer_un_fichier" title="Téléverser des fichiers [u]" accesskey="u"><span>Téléverser un fichier</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Sp%C3%A9cial:Pages_sp%C3%A9ciales" title="Liste de toutes les pages spéciales [q]" accesskey="q"><span>Pages spéciales</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&oldid=192277429" title="Adresse permanente de cette version de cette page"><span>Lien permanent</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=info" title="Davantage d’informations sur cette page"><span>Informations sur la page</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:Citer&page=M%C3%A9d%C3%A9tomidine&id=192277429&wpFormIdentifier=titleform" title="Informations sur la manière de citer cette page"><span>Citer cette page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:UrlShortener&url=https%3A%2F%2Ffr.wikipedia.org%2Fwiki%2FM%25C3%25A9d%25C3%25A9tomidine"><span>Obtenir l'URL raccourcie</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:QrCode&url=https%3A%2F%2Ffr.wikipedia.org%2Fwiki%2FM%25C3%25A9d%25C3%25A9tomidine"><span>Télécharger le code QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Imprimer / exporter </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:Livre&bookcmd=book_creator&referer=M%C3%A9d%C3%A9tomidine"><span>Créer un livre</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:DownloadAsPdf&page=M%C3%A9d%C3%A9tomidine&action=show-download-screen"><span>Télécharger comme PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&printable=yes" title="Version imprimable de cette page [p]" accesskey="p"><span>Version imprimable</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> Dans d’autres projets </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Medetomidine" hreflang="en"><span>Wikimedia Commons</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q427179" title="Lien vers l’élément dans le dépôt de données connecté [g]" accesskey="g"><span>Élément Wikidata</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Outils de la page"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Apparence"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Apparence</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">masquer</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Un article de Wikipédia, l'encyclopédie libre.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="fr" dir="ltr"><p class="mw-empty-elt"> </p> <table class="infobox_v2 infobox infobox--frwiki noarchive"> <tbody><tr> <td colspan="2" class="entete defaut" style="background-color:#FFDEAD;color:black;">Médétomidine </td></tr> <tr><td colspan="2" style="text-align:center; line-height: 1.5em;"><span typeof="mw:File/Frameless"><a href="/wiki/Fichier:(%C2%B1)-Medetomidine_Structural_Formulae.png" class="mw-file-description"><img alt="Image illustrative de l’article Médétomidine" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/25/%28%C2%B1%29-Medetomidine_Structural_Formulae.png/250px-%28%C2%B1%29-Medetomidine_Structural_Formulae.png" decoding="async" width="250" height="303" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/25/%28%C2%B1%29-Medetomidine_Structural_Formulae.png/375px-%28%C2%B1%29-Medetomidine_Structural_Formulae.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/25/%28%C2%B1%29-Medetomidine_Structural_Formulae.png/500px-%28%C2%B1%29-Medetomidine_Structural_Formulae.png 2x" data-file-width="1826" data-file-height="2213" /></a></span> </td></tr> <tr> <td colspan="2" style="text-align:center;"><a href="/wiki/%C3%89nantiom%C3%A8re" class="mw-redirect" title="Énantiomère">Énantiomère</a> R de la médétomidine (en haut) et S-médétomidine (en bas)</td> </tr><tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Identification</th></tr> <tr> <th scope="row"><a href="/wiki/Nomenclature_de_l%27UICPA" title="Nomenclature de l'UICPA">Nom UICPA</a> </th> <td><small>(<i>RS</i>)-4-[1-(2,3-diméthylphényl)-éthyl]-<i>1H</i>-imidazole</small> </td> </tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_CAS" title="Numéro CAS">N<sup>o</sup> CAS</a> </th> <td><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=86347-14-0&language=fr&title=Médétomidine">86347-14-0</a></span></span> (racémique)<br /><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=113775-47-6&language=fr&title=Médétomidine">113775-47-6</a></span></span> (D) ou <i>S</i>(+)<br /><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=119717-21-4&language=fr&title=Médétomidine">119717-21-4</a></span></span> (L) ou <i>R</i>(–) </td> </tr> <tr> <th scope="row"> N<sup>o</sup> <a href="/wiki/Agence_europ%C3%A9enne_des_produits_chimiques" title="Agence européenne des produits chimiques">ECHA</a> </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.242.450">100.242.450</a></span></span></td> </tr> <tr> <th scope="row"><a href="/wiki/PubChem" title="PubChem">PubChem</a> </th> <td><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=68602">68602</a></span> </td> </tr> <tr> <th scope="row"><a href="/wiki/Simplified_Molecular_Input_Line_Entry_System" title="Simplified Molecular Input Line Entry System">SMILES</a> </th> <td><div class="NavFrame" title="[Afficher]/[Masquer]" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;">CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C <br /><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/search/?smarts=CC1%3DC%28C%28%3DCC%3DC1%29C%28C%29C2%3DCN%3DCN2%29C">PubChem</a></span>, <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=M%C3%A9d%C3%A9tomidine&model=CC1%3DC%28C%28%3DCC%3DC1%29C%28C%29C2%3DCN%3DCN2%29C">vue 3D</a></span></div></div> </td> </tr> <tr> <th scope="row"><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a> </th> <td><div class="NavFrame" title="[Afficher]/[Masquer]" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;"><b>InChI :</b> <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=M%C3%A9d%C3%A9tomidine&model=InChI%3D1%2FC13H16N2%2Fc1-9-5-4-6-12%2810%289%292%2911%283%2913-7-14-8-15-13%2Fh4-8%2C11H%2C1-3H3%2C%28H%2C14%2C15%29%2Ff%2Fh15H">vue 3D</a></span> <br />InChI=1/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/f/h15H <br /></div></div> </td> </tr> <tr> <th scope="row">Apparence </th> <td>Poudre cristalloïde blanche • Solution limpide </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Propriétés chimiques</th></tr> <tr> <th scope="row"><a href="/wiki/Formule_chimique" title="Formule chimique">Formule</a> </th> <td><a href="/wiki/Carbone" title="Carbone">C</a><sub>13</sub><a href="/wiki/Hydrog%C3%A8ne" title="Hydrogène">H</a><sub>16</sub><a href="/wiki/Azote" title="Azote">N</a><sub>2</sub>  <span class="page_h"><a href="/wiki/C13H16N2" class="mw-disambig" title="C13H16N2"><small>[Isomères]</small></a></span><br /> </td> </tr> <tr> <th scope="row"><a href="/wiki/Masse_molaire" title="Masse molaire">Masse molaire</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup> </th> <td>200,279 5 ± 0,011 9 <a href="/wiki/Gramme" title="Gramme">g</a>/<a href="/wiki/Mole_(unit%C3%A9)" title="Mole (unité)">mol</a> <br /><small>C 77,96 %,  H 8,05 %,  N 13,99 %,  </small> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#DDFFDD; color:#000000">Données pharmacocinétiques</th></tr> <tr> <th scope="row"><a href="/wiki/M%C3%A9tabolisme" title="Métabolisme">Métabolisme</a> </th> <td><a href="/wiki/Foie" title="Foie">Hépatique</a> </td> </tr> <tr> <th scope="row"><a href="/wiki/Excr%C3%A9tion" title="Excrétion">Excrétion</a> </th> <td> <p><a href="/wiki/Rein" title="Rein">Urinaire</a> </p> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#DDFFDD; color:#000000">Considérations thérapeutiques</th></tr> <tr> <th scope="row">Classe thérapeutique </th> <td><a href="/wiki/Anesth%C3%A9sique" class="mw-redirect" title="Anesthésique">Sédatif</a> α<sub>2</sub>-agoniste </td> </tr> <tr> <th scope="row">Voie d’administration </th> <td>Voies intraveineuse, intramusculaire et sous-cutanée </td> </tr> <tr> <th scope="row"><a href="/wiki/Antidote" title="Antidote">Antidote</a> </th> <td><a href="/wiki/Atipam%C3%A9zole" title="Atipamézole">Atipamézole</a> </td> </tr> <tr> <td colspan="2"><hr style="height:2px; background-color:#FFDEAD;" /></td></tr> <tr> <td colspan="2" style="text-align:center;">Unités du <a href="/wiki/Syst%C3%A8me_international_d%27unit%C3%A9s" title="Système international d'unités">SI</a> et <a href="/wiki/Conditions_normales_de_temp%C3%A9rature_et_de_pression" title="Conditions normales de température et de pression"><abbr title="conditions normales de température et de pression">CNTP</abbr></a>, sauf indication contraire.</td> </tr><tr> <td class="navigation-only" colspan="2" style="border-top: 2px #FFDEAD solid; font-size: 80%; background:inherit; color: inherit; text-align: right;"><span class="plainlinks" style="float:left;"><a class="external text" href="https://fr.wikipedia.org/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=0"><span class="infodoc">modifier</span></a></span> <span typeof="mw:File"><a href="/wiki/Mod%C3%A8le:Infobox_Chimie" title="Consultez la documentation du modèle"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/12px-Info_Simple.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/18px-Info_Simple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/24px-Info_Simple.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></td> </tr> </tbody></table> <p>La <b>médétomidine</b> est un α<sub>2</sub>-agoniste utilisé en <a href="/wiki/Anesth%C3%A9siologie" class="mw-redirect" title="Anesthésiologie">anesthésiologie</a> vétérinaire. Il est l'un des sédatifs les plus puissants de sa classe. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Mode_d'action"><span id="Mode_d.27action"></span>Mode d'action</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=1" title="Modifier la section : Mode d'action" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=1" title="Modifier le code source de la section : Mode d'action"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La médétomidine agit sur les <a href="/wiki/R%C3%A9cepteurs_adr%C3%A9nergiques" class="mw-redirect" title="Récepteurs adrénergiques">récepteurs adrénergiques</a> α<sub>2</sub> localisés dans le <a href="/wiki/Syst%C3%A8me_nerveux_central" title="Système nerveux central">système nerveux central</a> et le <a href="/wiki/C%C5%93ur" title="Cœur">cœur</a>. Elle diminue la libération de <a href="/wiki/Noradr%C3%A9naline" title="Noradrénaline">noradrénaline</a> et provoque une inhibition du <a href="/wiki/Syst%C3%A8me_nerveux_sympathique" title="Système nerveux sympathique">système nerveux sympathique</a>. Ainsi, la médétomidine est responsable d'une diminution de la vigilance, de la nociception et du <a href="/wiki/Tonus_musculaire" title="Tonus musculaire">tonus musculaire</a>. À l'étage cardiaque, elle provoque une bradycardie : la fréquence cardiaque diminue de 40 à 50 % par rapport aux valeurs habituelles. </p><p>La médétomidine agit également, mais dans une moindre mesure, sur les récepteurs adrénergiques α<sub>1</sub> – son affinité pour les récepteurs α<sub>2</sub> est 1620 fois plus grande que pour les récepteurs α<sub>1</sub> – ce qui provoque une <a href="/wiki/Vasoconstriction" title="Vasoconstriction">vasoconstriction</a> périphérique et une hypertension. </p> <div class="mw-heading mw-heading2"><h2 id="Utilisation_/_Posologie"><span id="Utilisation_.2F_Posologie"></span>Utilisation / Posologie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=2" title="Modifier la section : Utilisation / Posologie" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=2" title="Modifier le code source de la section : Utilisation / Posologie"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La médétomidine possède une activité sympatholytique. Elle est utilisée en <a href="/wiki/M%C3%A9decine_v%C3%A9t%C3%A9rinaire" title="Médecine vétérinaire">médecine vétérinaire</a> comme sédatif, analgésique et myorelaxant. En anesthésiologie, elle est indiquée pour la prémédication et la sédanalgésie. Elle potentialise la narcose et la myorelaxation des anesthésiques halogénés volatils (halothane, <a href="/wiki/Isoflurane" title="Isoflurane">isoflurane</a>...). </p><p>La dose habituellement utilisée cliniquement varie entre 1 et 20 µg.kg-1 par voie intraveineuse, intramusculaire et sous-cutanée. Elle agit rapidement par voie intraveineuse et en 10 à 20 minutes par voie intramusculaire. L'effet analgésique dure entre 40 et 60 minutes et l'effet sédatif dure 60 à 120 minutes ; tous deux sont dose-dépendants. </p> <div class="mw-heading mw-heading2"><h2 id="Effets_secondaires">Effets secondaires</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=3" title="Modifier la section : Effets secondaires" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=3" title="Modifier le code source de la section : Effets secondaires"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La médétomidine provoque une dépression cardio-respiratoire importante à l'origine d'une <a href="/wiki/Bradycardie" title="Bradycardie">bradycardie</a> sinusale et d'une <a href="/wiki/Bradypn%C3%A9e" title="Bradypnée">bradypnée</a> dose-dépendantes. Elle induit également une vasoconstriction et une <a href="/wiki/Hypertension" class="mw-redirect" title="Hypertension">hypertension</a>. Elle diminue les contractions des muscles lisses : elle freine ainsi la motricité gastro-intestinale et provoque une <a href="/wiki/Mydriase" title="Mydriase">mydriase</a>. En outre, la médétomidine est hypoinsulinémiante et ainsi, secondairement hyperglycémiante, à l'origine d'une glycosurie, surtout chez le chat. Les α<sub>2</sub>-agonistes peuvent être utilisés chez le chat comme vomitifs lors d'intoxication aiguë par des toxiques non caustiques. </p> <div class="mw-heading mw-heading2"><h2 id="Contre-indications">Contre-indications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=4" title="Modifier la section : Contre-indications" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=4" title="Modifier le code source de la section : Contre-indications"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Contre-indications_relatives">Contre-indications relatives</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=5" title="Modifier la section : Contre-indications relatives" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=5" title="Modifier le code source de la section : Contre-indications relatives"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Hyperkali%C3%A9mie" title="Hyperkaliémie">Hyperkaliémie</a></li> <li><a href="/wiki/Insuffisance_r%C3%A9nale" class="mw-disambig" title="Insuffisance rénale">Insuffisance rénale</a></li> <li><a href="/wiki/Diab%C3%A8te_sucr%C3%A9" title="Diabète sucré">Diabète</a> non stabilisé</li></ul> <div class="mw-heading mw-heading3"><h3 id="Contre-indications_absolues">Contre-indications absolues</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=6" title="Modifier la section : Contre-indications absolues" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=6" title="Modifier le code source de la section : Contre-indications absolues"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Insuffisance_cardiaque" class="mw-redirect" title="Insuffisance cardiaque">Insuffisance cardiaque</a></li> <li><a href="/wiki/%C3%89tat_de_choc_circulatoire" title="État de choc circulatoire">États de choc</a></li> <li>Insuffisance hépato-cellulaire grave</li> <li>Obstacles mécaniques au péristaltisme</li></ul> <div class="mw-heading mw-heading2"><h2 id="Interactions_médicamenteuses"><span id="Interactions_m.C3.A9dicamenteuses"></span>Interactions médicamenteuses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=7" title="Modifier la section : Interactions médicamenteuses" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=7" title="Modifier le code source de la section : Interactions médicamenteuses"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Il est déconseillé d'administrer des anticholinergiques (<a href="/wiki/Atropine" title="Atropine">atropine</a>, glycopyrrolate) pour lutter contre la bradycardie car il existe d'importants risques d'hypertension sévère et d'arythmie. Certains <a href="/wiki/Opio%C3%AFde" title="Opioïde">opioïdes</a> (<a href="/wiki/Fentanyl" title="Fentanyl">fentanyl</a>, <a href="/wiki/Butorphanol" title="Butorphanol">butorphanol</a> et <a href="/wiki/P%C3%A9thidine" title="Péthidine">péthidine</a>) potentialisent les effets secondaires de la médétomidine. L'administration de <a href="/wiki/Propofol" title="Propofol">propofol</a> après la médétomidine est susceptible d'induire une <a href="/wiki/Hypox%C3%A9mie" title="Hypoxémie">hypoxémie</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Antagonisation">Antagonisation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=8" title="Modifier la section : Antagonisation" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=8" title="Modifier le code source de la section : Antagonisation"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La médétomidine est antagonisée par des α<sub>2</sub>-antagonistes, préférentiellement l'<a href="/wiki/Atipam%C3%A9zole" title="Atipamézole">atipamézole</a>. La <a href="/wiki/Yohimbine" title="Yohimbine">yohimbine</a> est à proscrire car elle peut potentialiser les effets secondaires de la médétomidine. </p> <div class="mw-heading mw-heading2"><h2 id="Références"><span id="R.C3.A9f.C3.A9rences"></span>Références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&veaction=edit&section=9" title="Modifier la section : Références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=M%C3%A9d%C3%A9tomidine&action=edit&section=9" title="Modifier le code source de la section : Références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><small>1. PLUMB D.C.<br />Veterinary Drug Handbook. 6<sup>th</sup> Ed., Iowa: Blackwell Publishing, 2008, 756 - 759.</small> </p><p><small>2. VERWAERDE P., ESTRADE C.<br />Vade-mecum d'anesthésie des Carnivores domestiques. 2005, Éd. MED'COM, 208 - 209.</small> </p> <div class="references-small decimal" style=""><div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink noprint"><a href="#cite_ref-1">↑</a> </span><span class="reference-text">Masse molaire calculée d’après <span class="ouvrage">« <a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/AtWt/"><cite style="font-style:normal;"><span class="lang-en" lang="en">Atomic weights of the elements 2007</span></cite></a> », sur <span class="italique">www.chem.qmul.ac.uk</span></span>.</span> </li> </ol></div> </div> <div class="navbox-container" style="clear:both;"> <table class="navbox collapsible noprint autocollapse" style=""> <tbody><tr><th class="navbox-title" colspan="2" style="text-align:center;"><div style="float:left; width:6em; text-align:left"><div class="noprint plainlinks nowrap tnavbar" style="padding:0; font-size:xx-small; color:var(--color-emphasized, #000000);"><a href="/wiki/Mod%C3%A8le:Palette_Alpha2-agonistes" title="Modèle:Palette Alpha2-agonistes"><abbr class="abbr" title="Voir ce modèle.">v</abbr></a> · <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Mod%C3%A8le:Palette_Alpha2-agonistes&action=edit"><abbr class="abbr" title="Modifier ce modèle. Merci de prévisualiser avant de sauvegarder.">m</abbr></a></div></div><div style="font-size:110%"><a href="/wiki/Alpha2-agoniste" title="Alpha2-agoniste">Alpha2-agonistes</a></div></th> </tr> <tr> <td class="navbox-list" style="text-align:center;;" colspan="2"><div class="liste-horizontale"> <ul><li><a href="/wiki/D%C3%A9tomidine" title="Détomidine">Détomidine</a></li> <li><a href="/wiki/Dexm%C3%A9d%C3%A9tomidine" title="Dexmédétomidine">Dexmédétomidine</a></li> <li><a class="mw-selflink selflink">Médétomidine</a></li> <li><a href="/wiki/Romifidine" title="Romifidine">Romifidine</a></li> <li><a href="/wiki/Xylazine" title="Xylazine">Xylazine</a></li></ul> </div></td> </tr> </tbody></table> <table class="navbox collapsible noprint autocollapse" style=""> <tbody><tr><th class="navbox-title" colspan="2" style=""><div style="float:left; width:6em; text-align:left"><div class="noprint plainlinks nowrap tnavbar" style="padding:0; font-size:xx-small; color:var(--color-emphasized, #000000);"><a href="/wiki/Mod%C3%A8le:Palette_S%C3%A9datif" title="Modèle:Palette Sédatif"><abbr class="abbr" title="Voir ce modèle.">v</abbr></a> · <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Mod%C3%A8le:Palette_S%C3%A9datif&action=edit"><abbr class="abbr" title="Modifier ce modèle. Merci de prévisualiser avant de sauvegarder.">m</abbr></a></div></div><div style="font-size:110%"><a href="/wiki/Psycholeptique" title="Psycholeptique">Psycholeptiques</a> : <a href="/wiki/Hypnotique" title="Hypnotique">hypnotiques</a> et <a href="/wiki/S%C3%A9datif" title="Sédatif">sédatifs</a> (<a href="/wiki/ATC_code_N05#N05C_Hypnotics_and_sedatives" class="mw-redirect" title="ATC code N05">N05C</a>)</div></th> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/R%C3%A9cepteurs_GABAA" class="mw-redirect" title="Récepteurs GABAA">Récepteurs GABA<sub>A</sub></a></th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Barbiturique" title="Barbiturique">Barbiturique</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale">action ultra-courte : <ul><li><a href="/wiki/M%C3%A9thohexital" title="Méthohexital">Méthohexital</a></li> <li><a href="/wiki/Thiamylal" title="Thiamylal">Thiamylal</a></li> <li><a href="/wiki/Thiopental" title="Thiopental">Thiopental</a></li></ul> </div> <div class="liste-horizontale">action courte et intermédiaire : <ul><li><a href="/w/index.php?title=Allobarbital&action=edit&redlink=1" class="new" title="Allobarbital (page inexistante)">Allobarbital</a></li> <li><a href="/wiki/Amobarbital" title="Amobarbital">Amobarbital</a></li> <li><a href="/w/index.php?title=Butabarbital&action=edit&redlink=1" class="new" title="Butabarbital (page inexistante)">Butabarbital</a></li> <li><a href="/wiki/Butobarbital" title="Butobarbital">Butobarbital</a></li> <li><a href="/wiki/Pentobarbital" title="Pentobarbital">Pentobarbital</a></li> <li><a href="/wiki/S%C3%A9cobarbital" title="Sécobarbital">Sécobarbital</a></li> <li><a href="/w/index.php?title=Talbutal&action=edit&redlink=1" class="new" title="Talbutal (page inexistante)">Talbutal</a></li></ul> </div> <div class="liste-horizontale">action longue : <ul><li><a href="/wiki/Barbiturique" title="Barbiturique">Barbital</a></li> <li><a href="/w/index.php?title=M%C3%A9phobarbital&action=edit&redlink=1" class="new" title="Méphobarbital (page inexistante)">Méphobarbital</a></li> <li><a href="/wiki/Ph%C3%A9nobarbital" title="Phénobarbital">Phénobarbital</a></li></ul> </div> <div class="liste-horizontale">non regroupés : <ul><li><a href="/w/index.php?title=Cyclobarbital&action=edit&redlink=1" class="new" title="Cyclobarbital (page inexistante)">Cyclobarbital</a></li> <li><a href="/w/index.php?title=%C3%89thallobarbital&action=edit&redlink=1" class="new" title="Éthallobarbital (page inexistante)">Éthallobarbital</a></li> <li><a href="/w/index.php?title=Heptabarbital&action=edit&redlink=1" class="new" title="Heptabarbital (page inexistante)">Heptabarbital</a></li> <li><a href="/w/index.php?title=Hexobarbital&action=edit&redlink=1" class="new" title="Hexobarbital (page inexistante)">Hexobarbital</a></li> <li><a href="/w/index.php?title=Proxibarbal&action=edit&redlink=1" class="new" title="Proxibarbal (page inexistante)">Proxibarbal</a></li> <li><a href="/w/index.php?title=Reposal&action=edit&redlink=1" class="new" title="Reposal (page inexistante)">Reposal</a></li> <li><a href="/w/index.php?title=Vinylbital&action=edit&redlink=1" class="new" title="Vinylbital (page inexistante)">Vinylbital</a></li> <li><a href="/w/index.php?title=Vinbarbital&action=edit&redlink=1" class="new" title="Vinbarbital (page inexistante)">Vinbarbital</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Benzodiaz%C3%A9pine" title="Benzodiazépine">Benzodiazépines</a></th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale">action courte : <ul><li><a href="/wiki/Brotizolam" title="Brotizolam">Brotizolam</a></li> <li><a href="/wiki/Cinolaz%C3%A9pam" title="Cinolazépam">Cinolazépam</a></li> <li><a href="/w/index.php?title=Doxefaz%C3%A9pam&action=edit&redlink=1" class="new" title="Doxefazépam (page inexistante)">Doxefazépam</a></li> <li><a href="/wiki/Loprazolam" title="Loprazolam">Loprazolam</a></li> <li><a href="/wiki/Midazolam" title="Midazolam">Midazolam</a></li> <li><a href="/wiki/Triazolam" title="Triazolam">Triazolam</a></li></ul> </div> <div class="liste-horizontale">action intermédiaire : <ul><li><a href="/wiki/Estazolam" title="Estazolam">Estazolam</a></li> <li><a href="/wiki/Flunitraz%C3%A9pam" title="Flunitrazépam">Flunitrazépam</a></li> <li><a href="/wiki/Lorm%C3%A9taz%C3%A9pam" title="Lormétazépam">Lormétazépam</a></li> <li><a href="/w/index.php?title=Nimetaz%C3%A9pam&action=edit&redlink=1" class="new" title="Nimetazépam (page inexistante)">Nimetazépam</a></li> <li><a href="/wiki/T%C3%A9maz%C3%A9pam" title="Témazépam">Témazépam</a></li></ul> </div> <div class="liste-horizontale">action longue : <ul><li><a href="/wiki/Fluraz%C3%A9pam" title="Flurazépam">Flurazépam</a></li> <li><a href="/w/index.php?title=Flutopraz%C3%A9pam&action=edit&redlink=1" class="new" title="Flutoprazépam (page inexistante)">Flutoprazépam</a></li> <li><a href="/wiki/Nitraz%C3%A9pam" title="Nitrazépam">Nitrazépam</a></li> <li><a href="/w/index.php?title=Quazepam&action=edit&redlink=1" class="new" title="Quazepam (page inexistante)">Quazepam</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon">Dialkylphénols</th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Fospropofol&action=edit&redlink=1" class="new" title="Fospropofol (page inexistante)">Fospropofol</a></li> <li><a href="/wiki/Propofol" title="Propofol">Propofol</a></li> <li><a href="/wiki/Thymol" title="Thymol">Thymol</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon">Non-benzodiazépines</th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=CL-218,872&action=edit&redlink=1" class="new" title="CL-218,872 (page inexistante)">CL-218,872</a></li> <li><a href="/wiki/Eszopiclone" title="Eszopiclone">Eszopiclone</a></li> <li><a href="/w/index.php?title=Indiplon&action=edit&redlink=1" class="new" title="Indiplon (page inexistante)">Indiplon</a></li> <li><a href="/w/index.php?title=Lirequinil&action=edit&redlink=1" class="new" title="Lirequinil (page inexistante)">Lirequinil</a></li> <li><a href="/w/index.php?title=N%C3%A9copidem&action=edit&redlink=1" class="new" title="Nécopidem (page inexistante)">Nécopidem</a></li> <li><a href="/w/index.php?title=Pazinaclone&action=edit&redlink=1" class="new" title="Pazinaclone (page inexistante)">Pazinaclone</a></li> <li><a href="/w/index.php?title=ROD-188&action=edit&redlink=1" class="new" title="ROD-188 (page inexistante)">ROD-188</a></li> <li><a href="/w/index.php?title=Saripidem&action=edit&redlink=1" class="new" title="Saripidem (page inexistante)">Saripidem</a></li> <li><a href="/wiki/Suproclone" title="Suproclone">Suproclone</a></li> <li><a href="/w/index.php?title=Suriclone&action=edit&redlink=1" class="new" title="Suriclone (page inexistante)">Suriclone</a></li> <li><a href="/w/index.php?title=SX-3228&action=edit&redlink=1" class="new" title="SX-3228 (page inexistante)">SX-3228</a></li> <li><a href="/w/index.php?title=U-89843A&action=edit&redlink=1" class="new" title="U-89843A (page inexistante)">U-89843A</a></li> <li><a href="/w/index.php?title=U-90042&action=edit&redlink=1" class="new" title="U-90042 (page inexistante)">U-90042</a></li> <li><a href="/wiki/Zaleplon" title="Zaleplon">Zaleplon</a></li> <li><a href="/wiki/Zolpidem" title="Zolpidem">Zolpidem</a></li> <li><a href="/wiki/Zopiclone" title="Zopiclone">Zopiclone</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/w/index.php?title=Pip%C3%A9ridinedione&action=edit&redlink=1" class="new" title="Pipéridinedione (page inexistante)">Pipéridinediones</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Glut%C3%A9thimide&action=edit&redlink=1" class="new" title="Glutéthimide (page inexistante)">Glutéthimide</a></li> <li><a href="/w/index.php?title=M%C3%A9thyprylon&action=edit&redlink=1" class="new" title="Méthyprylon (page inexistante)">Méthyprylon</a></li> <li><a href="/w/index.php?title=Pyrithyldione&action=edit&redlink=1" class="new" title="Pyrithyldione (page inexistante)">Pyrithyldione</a></li> <li><a href="/w/index.php?title=Pip%C3%A9ridione&action=edit&redlink=1" class="new" title="Pipéridione (page inexistante)">Pipéridione</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Quinazolinone" title="Quinazolinone">Quinazolinones</a></th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Afloqualone&action=edit&redlink=1" class="new" title="Afloqualone (page inexistante)">Afloqualone</a></li> <li><a href="/w/index.php?title=Cloroqualone&action=edit&redlink=1" class="new" title="Cloroqualone (page inexistante)">Cloroqualone</a></li> <li><a href="/w/index.php?title=Diproqualone&action=edit&redlink=1" class="new" title="Diproqualone (page inexistante)">Diproqualone</a></li> <li><a href="/w/index.php?title=%C3%89taqualone&action=edit&redlink=1" class="new" title="Étaqualone (page inexistante)">Étaqualone</a></li> <li><a href="/w/index.php?title=M%C3%A9broqualone&action=edit&redlink=1" class="new" title="Mébroqualone (page inexistante)">Mébroqualone</a></li> <li><a href="/w/index.php?title=M%C3%A9cloqualone&action=edit&redlink=1" class="new" title="Mécloqualone (page inexistante)">Mécloqualone</a></li> <li><a href="/wiki/M%C3%A9thaqualone" title="Méthaqualone">Méthaqualone</a></li> <li><a href="/w/index.php?title=M%C3%A9thylmethaqualone&action=edit&redlink=1" class="new" title="Méthylmethaqualone (page inexistante)">Méthylmethaqualone</a></li> <li><a href="/w/index.php?title=Nitrom%C3%A9thaqualone&action=edit&redlink=1" class="new" title="Nitrométhaqualone (page inexistante)">Nitrométhaqualone</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/St%C3%A9ro%C3%AFde_neuroactif" title="Stéroïde neuroactif">Stéroïde neuroactif</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Ac%C3%A9brochol&action=edit&redlink=1" class="new" title="Acébrochol (page inexistante)">Acébrochol</a></li> <li><a href="/wiki/Allopr%C3%A9gnanolone" title="Alloprégnanolone">Alloprégnanolone</a></li> <li><a href="/w/index.php?title=Alfadolone&action=edit&redlink=1" class="new" title="Alfadolone (page inexistante)">Alfadolone</a></li> <li><a href="/w/index.php?title=Alphaxolone&action=edit&redlink=1" class="new" title="Alphaxolone (page inexistante)">Alphaxolone</a></li> <li><a href="/w/index.php?title=Eltanolone&action=edit&redlink=1" class="new" title="Eltanolone (page inexistante)">Eltanolone</a></li> <li><a href="/wiki/Ganaxolone" title="Ganaxolone">Ganaxolone</a></li> <li><a href="/w/index.php?title=Hydroxydione&action=edit&redlink=1" class="new" title="Hydroxydione (page inexistante)">Hydroxydione</a></li> <li><a href="/w/index.php?title=Minaxolone&action=edit&redlink=1" class="new" title="Minaxolone (page inexistante)">Minaxolone</a></li> <li><a href="/w/index.php?title=Org_20599&action=edit&redlink=1" class="new" title="Org 20599 (page inexistante)">Org 20599</a></li> <li><a href="/w/index.php?title=Org_21465&action=edit&redlink=1" class="new" title="Org 21465 (page inexistante)">Org 21465</a></li> <li><a href="/w/index.php?title=T%C3%A9trahydrod%C3%A9oxycorticost%C3%A9rone&action=edit&redlink=1" class="new" title="Tétrahydrodéoxycorticostérone (page inexistante)">Tétrahydrodéoxycorticostérone</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/R%C3%A9cepteur_adr%C3%A9nergique#Récepteurs_Alpha-1" title="Récepteur adrénergique">Récepteurs adrénergiques alpha-2</a></th> <td class="navbox-list navbox-even" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/w/index.php?title=Agoniste_alpha-adr%C3%A9nergique&action=edit&redlink=1" class="new" title="Agoniste alpha-adrénergique (page inexistante)">Agoniste alpha-adrénergique</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=4-NEMD&action=edit&redlink=1" class="new" title="4-NEMD (page inexistante)">4-NEMD</a></li> <li><a href="/wiki/Clonidine" title="Clonidine">Clonidine</a></li> <li><a href="/wiki/Dexm%C3%A9d%C3%A9tomidine" title="Dexmédétomidine">Dexmédétomidine</a></li> <li><a href="/w/index.php?title=Lofexidine&action=edit&redlink=1" class="new" title="Lofexidine (page inexistante)">Lofexidine</a></li> <li><a class="mw-selflink selflink">Médétomidine</a></li> <li><a href="/wiki/Romifidine" title="Romifidine">Romifidine</a></li> <li><a href="/wiki/Tizanidine" title="Tizanidine">Tizanidine</a></li> <li><a href="/wiki/Xylazine" title="Xylazine">Xylazine</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/M%C3%A9latonine" title="Mélatonine">Récepteur de mélatonine</a></th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/M%C3%A9latonine" title="Mélatonine">Mélatonine</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Agom%C3%A9latine" title="Agomélatine">Agomélatine</a></li> <li><a href="/wiki/M%C3%A9latonine" title="Mélatonine">Mélatonine</a></li> <li><a href="/wiki/Ramelt%C3%A9on" class="mw-redirect" title="Rameltéon">Rameltéon</a></li> <li><a href="/wiki/Tasimelt%C3%A9on" title="Tasimeltéon">Tasimeltéon</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Histamine" title="Histamine">Récepteur d'histamine</a> et <a href="/wiki/Ac%C3%A9tylcholine" title="Acétylcholine">récepteur d'acétylcholine</a></th> <td class="navbox-list navbox-even" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Antihistaminique" title="Antihistaminique">Antihistaminiques</a> et <a href="/wiki/Anticholinergique" title="Anticholinergique">anticholinergiques</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Doxylamine" title="Doxylamine">Doxylamine</a></li> <li><a href="/wiki/Hydroxyzine" title="Hydroxyzine">Hydroxyzine</a></li> <li><a href="/wiki/Diph%C3%A9nhydramine" title="Diphénhydramine">Diphénhydramine</a></li> <li><a href="/w/index.php?title=Bromodiph%C3%A9nhydramine&action=edit&redlink=1" class="new" title="Bromodiphénhydramine (page inexistante)">Bromodiphénhydramine</a></li> <li><a href="/w/index.php?title=Carbinoxamine&action=edit&redlink=1" class="new" title="Carbinoxamine (page inexistante)">Carbinoxamine</a></li> <li><a href="/wiki/Orph%C3%A9nadrine" title="Orphénadrine">Orphénadrine</a></li> <li><a href="/wiki/Niaprazine" title="Niaprazine">Niaprazine</a></li> <li><a href="/w/index.php?title=Ph%C3%A9nyltoloxamine&action=edit&redlink=1" class="new" title="Phényltoloxamine (page inexistante)">Phényltoloxamine</a></li> <li><a href="/w/index.php?title=Propiomazine&action=edit&redlink=1" class="new" title="Propiomazine (page inexistante)">Propiomazine</a></li> <li><a href="/w/index.php?title=Pyrilamine&action=edit&redlink=1" class="new" title="Pyrilamine (page inexistante)">Pyrilamine</a></li> <li><a href="/wiki/Scopolamine" title="Scopolamine">Scopolamine</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/R%C3%A9cepteurs_GABAB" class="mw-redirect" title="Récepteurs GABAB">Récepteur GABA<sub>B</sub></a> et <a href="/wiki/Acide_gamma-hydroxybutyrique" title="Acide gamma-hydroxybutyrique">récepteurs GHB</a></th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon">Type <a href="/wiki/Acide_gamma-hydroxybutyrique" title="Acide gamma-hydroxybutyrique">GHB</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/1,4-butanediol" class="mw-redirect" title="1,4-butanediol">1,4-butanediol</a></li> <li><a href="/wiki/Acide_ac%C3%A9burique" title="Acide acéburique">Acide acéburique</a></li> <li><a href="/w/index.php?title=GABOB&action=edit&redlink=1" class="new" title="GABOB (page inexistante)">GABOB</a></li> <li><a href="/wiki/Acide_gamma-hydroxybutyrique" title="Acide gamma-hydroxybutyrique">GHB (Oxybate de sodium)</a></li> <li><a href="/wiki/Gamma-butyrolactone" class="mw-redirect" title="Gamma-butyrolactone">GBL</a></li> <li><a href="/wiki/Gamma-val%C3%A9rolactone" class="mw-redirect" title="Gamma-valérolactone">Gamma-valérolactone</a></li> <li><a href="/w/index.php?title=N-m%C3%A9thyl-GABA&action=edit&redlink=1" class="new" title="N-méthyl-GABA (page inexistante)">N-méthyl-GABA</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon">Autres récepteurs</th> <td class="navbox-list navbox-even" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Ald%C3%A9hyde" title="Aldéhyde">Aldéhydes</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Hydrate_d%27ac%C3%A9tylglycinamide_chloral&action=edit&redlink=1" class="new" title="Hydrate d'acétylglycinamide chloral (page inexistante)">Hydrate d'acétylglycinamide chloral</a></li> <li><a href="/wiki/Hydrate_de_chloral" title="Hydrate de chloral">Hydrate de chloral</a></li> <li><a href="/w/index.php?title=Chloralodol&action=edit&redlink=1" class="new" title="Chloralodol (page inexistante)">Chloralodol</a></li> <li><a href="/w/index.php?title=Dichloralph%C3%A9nazone&action=edit&redlink=1" class="new" title="Dichloralphénazone (page inexistante)">Dichloralphénazone</a></li> <li><a href="/wiki/Parald%C3%A9hyde" title="Paraldéhyde">Paraldéhyde</a></li> <li><a href="/w/index.php?title=P%C3%A9trichloral&action=edit&redlink=1" class="new" title="Pétrichloral (page inexistante)">Pétrichloral</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Alcyne" title="Alcyne">Alcynes</a></th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Centalun&action=edit&redlink=1" class="new" title="Centalun (page inexistante)">Centalun</a></li> <li><a href="/w/index.php?title=Ethchlorvynol&action=edit&redlink=1" class="new" title="Ethchlorvynol (page inexistante)">Ethchlorvynol</a></li> <li><a href="/w/index.php?title=%C3%89thinamate&action=edit&redlink=1" class="new" title="Éthinamate (page inexistante)">Éthinamate</a></li> <li><a href="/w/index.php?title=Hexapropymate&action=edit&redlink=1" class="new" title="Hexapropymate (page inexistante)">Hexapropymate</a></li> <li><a href="/w/index.php?title=M%C3%A9thylpentynol&action=edit&redlink=1" class="new" title="Méthylpentynol (page inexistante)">Méthylpentynol</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Carbamate" title="Carbamate">Carbamates</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/M%C3%A9probamate" title="Méprobamate">Méprobamate</a></li> <li><a href="/wiki/Carisoprodol" title="Carisoprodol">Carisoprodol</a></li> <li><a href="/w/index.php?title=Tybamate&action=edit&redlink=1" class="new" title="Tybamate (page inexistante)">Tybamate</a></li> <li><a href="/wiki/M%C3%A9thocarbamol" title="Méthocarbamol">Méthocarbamol</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon">Autre</th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=2-m%C3%A9thyl-2-butanol&action=edit&redlink=1" class="new" title="2-méthyl-2-butanol (page inexistante)">2-méthyl-2-butanol</a></li> <li><a href="/w/index.php?title=Ac%C3%A9carbromal&action=edit&redlink=1" class="new" title="Acécarbromal (page inexistante)">Acécarbromal</a></li> <li><a href="/wiki/Apronal" title="Apronal">Apronal</a></li> <li><a href="/wiki/Bromure" title="Bromure">Bromures</a></li> <li><a href="/wiki/Bromisoval" title="Bromisoval">Bromisoval</a></li> <li><a href="/w/index.php?title=Carbromal&action=edit&redlink=1" class="new" title="Carbromal (page inexistante)">Carbromal</a></li> <li><a href="/wiki/Chloralose" title="Chloralose">Chloralose</a></li> <li><a href="/wiki/Clom%C3%A9thiazole" title="Clométhiazole">Clométhiazole</a></li> <li><a href="/wiki/Embutramide" title="Embutramide">Embutramide</a></li> <li><a href="/wiki/%C3%89tomidate" title="Étomidate">Étomidate</a></li> <li><a href="/wiki/%C3%89voxine" title="Évoxine">Évoxine</a></li> <li><a href="/w/index.php?title=Gaboxadol&action=edit&redlink=1" class="new" title="Gaboxadol (page inexistante)">Gaboxadol</a></li> <li><a href="/w/index.php?title=Lor%C3%A9cl%C3%A9zole&action=edit&redlink=1" class="new" title="Loréclézole (page inexistante)">Loréclézole</a></li> <li><a href="/w/index.php?title=Mephenoxalone&action=edit&redlink=1" class="new" title="Mephenoxalone (page inexistante)">Mephenoxalone</a></li> <li><a href="/w/index.php?title=Sulfonem%C3%A9thane&action=edit&redlink=1" class="new" title="Sulfoneméthane (page inexistante)">Sulfoneméthane</a></li> <li><a href="/w/index.php?title=2,2,2-trichloro%C3%A9thanol&action=edit&redlink=1" class="new" title="2,2,2-trichloroéthanol (page inexistante)">Trichloroéthanol</a></li> <li><a href="/wiki/Triclofos" title="Triclofos">Triclofos</a></li> <li><a href="/wiki/Val%C3%A9riane" title="Valériane">Valériane</a></li> <li><a href="/wiki/Valnoctamide" title="Valnoctamide">Valnoctamide</a></li> <li><a href="/wiki/Trazodone" 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