CINXE.COM
Cartographers of the human body: the Human Cell Atlas
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href="https://twitter.com/intent/tweet?url=http%3A%2F%2Fwww.cam.ac.uk%2Fstories%2Fhuman-cell-atlas-2024&text=The%20Human%20Cell%20Atlas%20is%20an%20ambitious%20project%20to%20map%20every%20cell%20in%20the%20human%20body.%20Its%20co-lead%2C%20Professor%20Sarah%20Teichmann%2C%20explains%20how%20the%20initiative%20is%20already%20changing%20our%20understanding%20of%20our%20bodies.%0A" data-social-share="twitter" data-testid="Header--btn-Twitter">Twitter</a></span><span class="Theme-SocialButton"><a class="Theme-FaceboookButton Theme-FacebookButton" href="https://www.facebook.com/sharer/sharer.php?u=http%3A%2F%2Fwww.cam.ac.uk%2Fstories%2Fhuman-cell-atlas-2024" data-social-share="facebook" data-testid="Header--btn-Facebook">Facebook</a></span></div> </div> </div> <article id="article" class="Core--rootElement Theme-Story" role="main"> <header id="section-luURnPar0Q" class="Theme-Section Theme-TitleSection Theme-Section-Position-1 DisplayContainerHeight DisplayContainerHeight--minHeight DisplayContainerHeight--flex Theme-Section-Layout--Half SplitLayout SplitLayout--rowReverse SplitLayout--columnReverse Theme-Section-Layout--Landscapeleft Theme-Section-Layout--Portraittop Theme-Section-Custom Theme-BackgroundColor-0 Theme-ForegroundColor-13 Theme-Section-HasOverlay" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsInRleHRGYWRlIjoibm9uZSIsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layout FullSize--fullHeight Theme-Layer-TextBlock Layer--one"> <div class="Layout__flex--xcenter Layout__flex--ycenter Theme-Layer-TextBlock-Container" data-scrollymoly-basis="true" data-testid="ENG-5457"> <div class="Theme-Layer-TextBlock-Inner DisplayContainer--heightBasis"> <div> <div> <h1 class="Theme-StoryTitle Theme-TextSize-small h-align-center"><strong>Cartographers of the human body</strong></h1> <p class="Theme-TextSize-xsmall h-align-center"><span class="Theme-ForegroundColor-13">The Human Cell Atlas</span></p> </div> </div> </div> </div> <div class="Layout__flex--xcenter Layout__flex--ybottom Theme-Layer-TextBlock-Container" data-scrollymoly-basis="true" data-testid="ENG-5457"> <div class="Theme-Layer-TextBlock-Inner DisplayContainer--heightBasis"> <div> <div class="Theme-Byline"> <p class="Theme-Text h-align-center"><strong>By </strong><a href="mailto:craig.brierley@admin.cam.ac.uk"><strong>Craig Brierley</strong></a></p> </div> </div> </div> </div> </div> <div class="Layer--two FullSize FullSize--scrollChild FullSize--child SplitLayout--media Theme-BackgroundMedia Theme-BackgroundImage"> <div data-instant-image-container="true" id="luURnPar0Q-background-viewport" class="FullSize--fullWidth FullSize--fullHeight Core--pointerEventsNone"> <picture class="FullSize--fullWidth FullSize--fullHeight FullSize--scrollChild Theme-Item-Picture" data-landscape-focal="38% 50%" data-portrait-focal="50% 50%"> <source 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"><img 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Theme-Section-Layout--Landscaperight Theme-Section-Layout--Portraittop Theme-Section-Custom Theme-BackgroundColor-0 Theme-ForegroundColor-13 Theme-Section-HasOverlay" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsInRleHRGYWRlIjoibm9uZSIsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layout FullSize--fullHeight Theme-Layer-TextBlock Layer--one"> <div class="Layout__flex--xcenter Layout__flex--ycenter Theme-Layer-TextBlock-Container" data-scrollymoly-basis="true" data-testid="ENG-5457"> <div class="Theme-Layer-TextBlock-Inner DisplayContainer--heightBasis"> <div> <div class="Theme-Title"> <h2 class="Theme-Title Theme-TextSize-xxsmall h-align-center"><strong>The Human Cell Atlas is an ambitious project to map every cell in the human body. As it releases a suite of new studies, its co-lead, Professor Sarah Teichmann, explains how the initiative is already changing our understanding of our bodies.</strong></h2> </div> </div> </div> </div> </div> <div class="Layer--two FullSize FullSize--scrollChild FullSize--child SplitLayout--media Theme-BackgroundMedia Theme-BackgroundImage"> <div data-lazyload-container="true" data-lazyload-trigger="true" class="FullSize--fullWidth FullSize--fullHeight Core--pointerEventsNone Lazyload Lazyload--isLoading"> <div class="FullSize Lazyload__loading" aria-hidden="true"> <picture class="FullSize--fullWidth FullSize--fullHeight Theme-Item-InstantImage" aria-hidden="true" data-landscape-focal="84% 50%" data-portrait-focal="84% 50%"> <source media="(min-aspect-ratio: 1/1)" 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sizes="(max-aspect-ratio: 2560/1440) 178vh, 100vw"><img class="FullSize FullSize--fullWidth FullSize--fullHeight ObjectFit--cover" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/pK8h69X6Dx/024a7772-enhanced-nr-land-2560x1440.jpg" alt="" style="object-position:84% 50%"> </picture> </div> </div> <div class="FullSize Theme-Overlay Theme-Section-Custom Theme-ForegroundColor-13 Theme-BackgroundColor-0" style="opacity:0.05"></div> </div> </div> <div id="section-qAi2eBCsTt" class="Theme-Section Theme-TextSection Theme-Section-Position-3 Theme-Section-Layout--Full Theme-BodyTextColumn-Center Theme-Columns--1" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layer--one"> <div class="Layout"> <div class="Layout__row"> <div class="Layout__col Layout__col-lg-6 Layout__offset-lg-3 Layout__col-md-6 Layout__offset-md-3 Layout__col-sm-10 Layout__offset-sm-0 Layout__col-xs-12 Layout__offset-xs-0 Theme-Column"> <div class="Theme-Layer-BodyText"> <div class="Theme-Layer-BodyText--inner"> <p class="MsoNormal">Ozempic – the ‘weight loss jab’ everyone is talking about – has a strange side effect: many people who receive it find their heart rates increasing by around six beats per minute.</p> <p class="MsoNormal">The reason why this should happen was a mystery, until researchers at Cambridge spotted something surprising about our ‘pacemaker cells’ (the cells that set our heart rate). 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But the Cambridge team spotted that GLP1 also binds to a ‘receptor’ protein on the surface of pacemaker cells, thus increasing our heart rate.</p> <p class="MsoNormal">The team behind this discovery is among more than 3,600 scientists (including over 70 at the University of Cambridge) in over 100 countries – on every continent other than Antarctica – working on what is arguably one of the most ambitious scientific projects ever launched: to map every one of the 37 trillion cells in the human body.</p> <figure class="InlineMedia InlineMedia--image media-size-100" data-lazyload-container="true" data-lazyload-trigger="true"> <div class="InlineMedia--image__inner crop-uncropped" style="overflow:hidden;border-top-left-radius:calc(0rem * var(--corner-multiplier));border-top-right-radius:calc(0rem * var(--corner-multiplier));border-bottom-left-radius:calc(0rem * var(--corner-multiplier));border-bottom-right-radius:calc(0rem * 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data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/ERUb88L5BM/aviv-regev_credit-genentech-crop-900x600.jpg" alt=""> </picture> </div> </div> <figcaption class="Theme-Caption Theme-InlineMediaCaption"> <div class="Display--none Display--md-block"> <p class="">Dr Aviv Regev (Genentech)</p> </div> <div class="Display--md-none"> <p class="">Dr Aviv Regev (Genentech)</p> </div> </figcaption> </figure> <p class="">“The Human Cell Atlas is a project to map the cell types in the human body in terms of their complete molecular fingerprint,” says Teichmann. “The way we do that is by using genomics technologies that have been developed over the past dozen years or so that are part of what I'd call the ‘resolution revolution’ in genomics.”</p> </div> <div class="FullSize Theme-Overlay" style="opacity:0"></div> </div> </div> </div> </div> </div> </div> <div id="section-VnrPyrBAP8" class="Theme-Section Theme-TextOverMediaSection Theme-Section-Position-4 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https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-1496x842.jpg 1496w, https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2090x1176.jpg 2090w, https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2560x1440.jpg 2560w" type="image/jpeg" media="(max-aspect-ratio: 1/1)" sizes="(max-aspect-ratio: 2560/1440) 178vh, 100vw"><img class="FullSize FullSize--fullWidth FullSize--fullHeight ObjectFit--cover" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2560x1440.jpg" alt="" style="object-position:50% 50%"> </picture> </div> </div> <div class="FullSize Theme-Overlay Theme-Section-Dark" style="opacity:0.5"></div> </div> </div> <div id="section-tnDdnYyHAt" class="Theme-Section Theme-TextSection Theme-Section-Position-5 Theme-Section-Layout--Full Theme-Section-Light Theme-BodyTextColumn-Center Theme-Columns--1" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layer--one"> <div class="Layout"> <div class="Layout__row"> <div class="Layout__col Layout__col-lg-6 Layout__offset-lg-3 Layout__col-md-6 Layout__offset-md-3 Layout__col-sm-10 Layout__offset-sm-0 Layout__col-xs-12 Layout__offset-xs-0 Theme-Column"> <div class="Theme-Layer-BodyText"> <div class="Theme-Layer-BodyText--inner"> <p class="MsoNormal">Almost every cell in a person’s body contains the same genetic blueprint, written in DNA. The reason that a heart cell is a heart cell and a brain cell is a brain cell, however, is because not every gene is active in each cell. By looking another molecule – RNA, which ‘translates’ DNA into the proteins that make our bodies work – scientists can determine exactly which genes are active and in which cells. This picture can be finessed even further by looking at epigenetic modifications to the genetic code – that is, small molecules that sit on the DNA and turn the ‘volume’ of the genes up and down – and by measuring protein levels within the cells.</p> <p class="MsoNormal">“Having this data at such a high resolution of the individual cell has been a real game changer,” says Teichmann. “It’s what's really opened up all of the new insights.”</p> <p class="MsoNormal">Being able to make these measurements at single cell resolution allows researchers not only to describe the difference between a heart cell and a muscle cell, for example, or even a cell in the wall of the heart’s atrium and a cell in its ventricle – they can even tell the difference between different subsets of cardiomyocytes (the cells that make up cardiac muscle and are responsible for the heart's contraction).</p> <figure class="InlineMedia InlineMedia--image media-size-100" data-lazyload-container="true" data-lazyload-trigger="true"> <div class="InlineMedia--image__inner crop-uncropped" style="overflow:hidden;border-top-left-radius:calc(0rem * var(--corner-multiplier));border-top-right-radius:calc(0rem * var(--corner-multiplier));border-bottom-left-radius:calc(0rem * var(--corner-multiplier));border-bottom-right-radius:calc(0rem * var(--corner-multiplier));--media-width:900px;--media-height:695px"> <div class="Lazyload__loading" aria-hidden="true"> <div class="Display--none Display--md-block"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgOTAwIDY5NSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB3aWR0aD0iOTAwIiBoZWlnaHQ9IjY5NSI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSI+PC9yZWN0Pjwvc3ZnPg=="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> <div class="Display--md-none"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgOTAwIDY5NSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB3aWR0aD0iOTAwIiBoZWlnaHQ9IjY5NSI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSI+PC9yZWN0Pjwvc3ZnPg=="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> </div> <div data-lazyload-item="true" class="FullSize"> <picture> <source media="(min-width: 901px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/0aD9pTny9D/the-human-small-intestine-image-credit-grace-burgin-noga-rogel-and-moshe-biton-klarman-cell-observatory-broad-institute-900x695.jpg"> <source media="(max-width: 900px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/0aD9pTny9D/the-human-small-intestine-image-credit-grace-burgin-noga-rogel-and-moshe-biton-klarman-cell-observatory-broad-institute-900x695.jpg"><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/0aD9pTny9D/the-human-small-intestine-image-credit-grace-burgin-noga-rogel-and-moshe-biton-klarman-cell-observatory-broad-institute-900x695.jpg" alt=""> </picture> </div> </div> <figcaption class="Theme-Caption Theme-InlineMediaCaption"> <div class="Display--none Display--md-block"> <p class="">The human small intestine (Grace Burgin, Noga Rogel & Moshe Biton, Klarman Cell Observatory, Broad Institute)</p> </div> <div class="Display--md-none"> <p class="">The human small intestine (Grace Burgin, Noga Rogel & Moshe Biton, Klarman Cell Observatory, Broad Institute)</p> </div> </figcaption> </figure> <p class="MsoNormal">“At a very coarse, grand level, if you look up <a href="https://en.wikipedia.org/wiki/List_of_human_cell_types#List_of_human_cell_types">cell types on Wikipedia</a>, it says there are about 200 cell types, whereas with these new technologies, the Human Cell Atlas has been able to distinguish thousands of nerve cell subtypes alone!”</p> <h4 class="Theme-Layer-BodyText-Heading-xs MsoNormal Theme-TextSize-xxxsmall"><span class="Theme-ForegroundColor-0">"It's incredibly exciting from a discovery science point of view. That's what gets a lot of people up in the morning. But it's also got massive meaning from a diagnostics and drug discovery point of view."</span></h4> <p class=""><span class="Theme-ForegroundColor-0"><sup><strong>Sarah Teichmann</strong></sup></span></p> <p class="MsoNormal">Much of drug discovery work involves the use of animal models, particularly mice – a significant proportion of mouse genes have human analogues and their physiology shares some of the same characteristics as ours. But while useful for studying our human biology and disease, there are also fundamental differences. The discovery of the GLP1 receptor on human pacemaker cells, for example, surprised scientists because it has not been found in mouse pacemaker cells.</p> <p class="MsoNormal">“Having a healthy human map for large cohorts of people helps us understand what the cells are like in their normal ground state or reference state and then provide that framework for comparison to disease samples. It allows us to study the mechanisms of disease and to understand progressions of disease better for drug discovery.”</p> </div> <div class="FullSize Theme-Overlay" style="opacity:0"></div> </div> </div> </div> </div> </div> </div> <div id="section-wBupjrTT5l" class="Theme-Section Theme-TextOverMediaSection Theme-Section-Position-6 DisplayContainerHeight--heightThird DisplayContainerHeight--minHeightThird DisplayContainerHeight--flex Theme-Section-Layout--Full Theme-Section-Dark Theme-Section-HasOverlay" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsInRleHRGYWRlIjoibm9uZSIsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layout FullSize--fullHeight Theme-Layer-TextBlock Layer--one"> <div class="Layout__flex--xcenter Layout__flex--ycenter Theme-Layer-TextBlock-Container" data-scrollymoly-basis="true" data-testid="ENG-5457"> <div class="Theme-Layer-TextBlock-Inner DisplayContainer--heightBasis"> <div> <div class="Theme-Title"> <h2 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https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-1496x842.jpg 1496w, https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2090x1176.jpg 2090w, https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2560x1440.jpg 2560w" type="image/jpeg" media="(max-aspect-ratio: 1/1)" sizes="(max-aspect-ratio: 2560/1440) 178vh, 100vw"><img class="FullSize FullSize--fullWidth FullSize--fullHeight ObjectFit--cover" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2560x1440.jpg" alt="" style="object-position:50% 50%"> </picture> </div> </div> <div class="FullSize Theme-Overlay Theme-Section-Dark" style="opacity:0.5"></div> </div> </div> <div id="section-Zie6LzRBuH" class="Theme-Section Theme-TextSection Theme-Section-Position-7 Theme-Section-Layout--Full Theme-Section-Light Theme-BodyTextColumn-Center Theme-Columns--1" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layer--one"> <div class="Layout"> <div class="Layout__row"> <div class="Layout__col Layout__col-lg-6 Layout__offset-lg-3 Layout__col-md-6 Layout__offset-md-3 Layout__col-sm-10 Layout__offset-sm-0 Layout__col-xs-12 Layout__offset-xs-0 Theme-Column"> <div class="Theme-Layer-BodyText"> <div class="Theme-Layer-BodyText--inner"> <p class="MsoNormal">Today sees a landmark moment for the project, with the publication of 13 new papers in the prestigious <em>Nature</em> journals. Together with a number of papers published recently and a handful more to come, these are being released as <a href="https://www.nature.com/immersive/d42859-024-00060-5/index.html">a collection of 43 HCA papers</a>.</p> <p class="">Asked what are some of the key discoveries enabled by the HCA, Teichmann says it’s difficult to know where to even begin.</p> <p class="">“I can bore you to death on exciting cell discoveries!” she says. “It's changed how we understand our brain. It’s changed how we understand the immune system. It's changed how we understand the hormonal signalling across the human body. It's changed how we understand vasculature – the blood vessels. It's really changed everything.”</p> </div> <div class="FullSize Theme-Overlay" style="opacity:0"></div> </div> </div> </div> </div> </div> </div> <div id="section-VS8jxB7q1q" class="Theme-Section Theme-TextSection Theme-Section-Position-8 Theme-Section-Layout--Full Theme-Section-Custom Theme-BackgroundColor-0 Theme-ForegroundColor-13 Theme-BodyTextColumn-Center Theme-Columns--1" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layer--one"> <div class="Layout"> <div class="Layout__row"> <div class="Layout__col Layout__col-lg-6 Layout__offset-lg-3 Layout__col-md-6 Layout__offset-md-3 Layout__col-sm-10 Layout__offset-sm-0 Layout__col-xs-12 Layout__offset-xs-0 Theme-Column"> <div class="Theme-Layer-BodyText Theme-ForegroundColor-13"> <div class="Theme-Layer-BodyText--inner"> <h3 class="Theme-Layer-BodyText-Heading-Small Theme-SubTitle MsoNormal Theme-TextSize-xxsmall"><strong>Highlights from the Collection</strong></h3> <p class="MsoNormal">Several studies in the collection provide a detailed analysis of specific tissues and organs and reveal new biological discoveries important for understanding disease – for example, a cell atlas of the human gut from healthy and diseased tissue identified a gut cell type that may be involved in gut inflammation, providing a valuable resource for investigating and ultimately treating conditions such as ulcerative colitis and Crohn’s disease. </p> <p class="MsoNormal">The new collection of papers also includes maps of human tissues during development. These include the first map of human skeletal development, revealing how the skeleton forms, shedding light on the origins of arthritis, and identifying cells involved in skeletal conditions.</p> <figure class="InlineMedia InlineMedia--image h-align-center media-size-100" data-lazyload-container="true" data-lazyload-trigger="true"> <div class="InlineMedia--image__inner crop-uncropped" style="overflow:hidden;border-top-left-radius:calc(0rem * var(--corner-multiplier));border-top-right-radius:calc(0rem * var(--corner-multiplier));border-bottom-left-radius:calc(0rem * var(--corner-multiplier));border-bottom-right-radius:calc(0rem * var(--corner-multiplier));--media-width:1673px;--media-height:1173px"> <div class="Lazyload__loading" aria-hidden="true"> <div class="Display--none Display--md-block"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgMTY3MyAxMTczIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSIxNjczIiBoZWlnaHQ9IjExNzMiPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiPjwvcmVjdD48L3N2Zz4="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> <div class="Display--md-none"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgMTY3MyAxMTczIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSIxNjczIiBoZWlnaHQ9IjExNzMiPjxyZWN0IHdpZHRoPSIxMDAlIiBoZWlnaHQ9IjEwMCUiPjwvcmVjdD48L3N2Zz4="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> </div> <div data-lazyload-item="true" class="FullSize"> <picture> <source media="(min-width: 901px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/h04SelRS60/3d-rendered-video-of-developing-skeleton-1673x1173.jpg"> <source media="(max-width: 900px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/h04SelRS60/3d-rendered-video-of-developing-skeleton-1673x1173.jpg"><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/h04SelRS60/3d-rendered-video-of-developing-skeleton-1673x1173.jpg" alt=""> </picture> </div> </div> <figcaption class="Theme-Caption Theme-InlineMediaCaption"> <div class="Display--none Display--md-block"> <p class="">3D-rendered image of developing skeleton showing cartilage and bone (A Chédotal & R Blain, Institut de la Vision, Paris & MeLiS/UCBL/ HCL, Lyon)</p> </div> <div class="Display--md-none"> <p class="">3D-rendered image of developing skeleton showing cartilage and bone (A Chédotal & R Blain, Institut de la Vision, Paris & MeLiS/UCBL/ HCL, Lyon)</p> </div> </figcaption> </figure> <p class="">An additional study describes an atlas of the first trimester placenta, including insight into genetic programmes that control how the it develops and functions to provide nutrients and protection to the embryo. These and other developmental biology studies in the collection increase our fundamental understanding of healthy development in time and space, and provide blueprints and resources for creating therapeutics, since many diseases have their origin in human development.</p> <figure class="InlineMedia InlineMedia--image media-size-100" data-lazyload-container="true" data-lazyload-trigger="true"> <div class="InlineMedia--image__inner crop-uncropped" style="overflow:hidden;border-top-left-radius:calc(0rem * var(--corner-multiplier));border-top-right-radius:calc(0rem * var(--corner-multiplier));border-bottom-left-radius:calc(0rem * var(--corner-multiplier));border-bottom-right-radius:calc(0rem * var(--corner-multiplier));--media-width:900px;--media-height:630px"> <div class="Lazyload__loading" aria-hidden="true"> <div class="Display--none Display--md-block"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgOTAwIDYzMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB3aWR0aD0iOTAwIiBoZWlnaHQ9IjYzMCI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSI+PC9yZWN0Pjwvc3ZnPg=="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> <div class="Display--md-none"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgOTAwIDYzMCIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB3aWR0aD0iOTAwIiBoZWlnaHQ9IjYzMCI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSI+PC9yZWN0Pjwvc3ZnPg=="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> </div> <div data-lazyload-item="true" class="FullSize"> <picture> <source media="(min-width: 901px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/JKHQKBbbuv/blood-vessels-in-a-human-ileum-sample_creditana-maria-cujba-catherine-tudor-and-rasa-elmentaite-crop-900x630.jpg"> <source media="(max-width: 900px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/JKHQKBbbuv/blood-vessels-in-a-human-ileum-sample_creditana-maria-cujba-catherine-tudor-and-rasa-elmentaite-crop-900x630.jpg"><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/JKHQKBbbuv/blood-vessels-in-a-human-ileum-sample_creditana-maria-cujba-catherine-tudor-and-rasa-elmentaite-crop-900x630.jpg" alt=""> </picture> </div> </div> <figcaption class="Theme-Caption Theme-InlineMediaCaption"> <div class="Display--none Display--md-block"> <p class="">Blood vessels in a human ileum, part of the small intenstine (Ana-Maria Cujba Catherine Tudor and Rasa Elmentaite)</p> </div> <div class="Display--md-none"> <p class="">Blood vessels in a human ileum, part of the small intenstine (Ana-Maria Cujba Catherine Tudor and Rasa Elmentaite)</p> </div> </figcaption> </figure> <p class="MsoNormal">An accompanying article highlights the importance of including samples from historically underrepresented human populations, and describes actions and principles aimed at promoting equitable science. </p> </div> <div class="FullSize Theme-Overlay Theme-Section-Custom Theme-BackgroundColor-0" style="opacity:0"></div> </div> </div> </div> </div> </div> </div> <div id="section-U2g1jaNLg7" class="Theme-Section Theme-TextOverMediaSection Theme-Section-Position-9 DisplayContainerHeight--heightThird DisplayContainerHeight--minHeightThird DisplayContainerHeight--flex Theme-Section-Layout--Full Theme-Section-Dark Theme-Section-HasOverlay" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsInRleHRGYWRlIjoibm9uZSIsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layout FullSize--fullHeight Theme-Layer-TextBlock Layer--one"> <div class="Layout__flex--xcenter Layout__flex--ycenter Theme-Layer-TextBlock-Container" data-scrollymoly-basis="true" data-testid="ENG-5457"> <div class="Theme-Layer-TextBlock-Inner DisplayContainer--heightBasis"> <div> <div class="Theme-Title"> <h2 class="Theme-Title Theme-TextSize-small"><strong>Open for everyone</strong></h2> </div> </div> </div> </div> </div> <div class="Layer--two FullSize FullSize--scrollChild FullSize--child Theme-BackgroundMedia Theme-BackgroundImage"> <div data-lazyload-container="true" data-lazyload-trigger="true" class="FullSize--fullWidth FullSize--fullHeight Core--pointerEventsNone Lazyload Lazyload--isLoading"> <div class="FullSize Lazyload__loading" aria-hidden="true"> <picture class="FullSize--fullWidth FullSize--fullHeight Theme-Item-InstantImage" aria-hidden="true" data-landscape-focal="50% 50%" data-portrait-focal="50% 50%"> <source media="(min-aspect-ratio: 1/1)" 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https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-1496x842.jpg 1496w, https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2090x1176.jpg 2090w, https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2560x1440.jpg 2560w" type="image/jpeg" media="(max-aspect-ratio: 1/1)" sizes="(max-aspect-ratio: 2560/1440) 178vh, 100vw"><img class="FullSize FullSize--fullWidth FullSize--fullHeight ObjectFit--cover" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/uEpdPhcbWJ/periodic-table-of-cells_credit-ania-hupalowska-land-2560x1440.jpg" alt="" style="object-position:50% 50%"> </picture> </div> </div> <div class="FullSize Theme-Overlay Theme-Section-Dark" style="opacity:0.5"></div> </div> </div> <div id="section-Ebry116HsU" class="Theme-Section Theme-TextSection Theme-Section-Position-10 Theme-Section-Layout--Full Theme-Section-Light Theme-BodyTextColumn-Center Theme-Columns--1" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layer--one"> <div class="Layout"> <div class="Layout__row"> <div class="Layout__col Layout__col-lg-6 Layout__offset-lg-3 Layout__col-md-6 Layout__offset-md-3 Layout__col-sm-10 Layout__offset-sm-0 Layout__col-xs-12 Layout__offset-xs-0 Theme-Column"> <div class="Theme-Layer-BodyText"> <div class="Theme-Layer-BodyText--inner"> <p class="MsoNormal">The Human Cell Atlas has even helped change public health policy. Just over three years after it launched at its inaugural meeting at the Wellcome Trust, London, in 2016, the world was struck down by the appearance of a new virus, SARS-CoV-2, causing the Covid-19 pandemic.</p> <figure class="InlineMedia InlineMedia--image media-size-100" data-lazyload-container="true" data-lazyload-trigger="true"> <div class="InlineMedia--image__inner crop-uncropped" style="overflow:hidden;border-top-left-radius:calc(0rem * var(--corner-multiplier));border-top-right-radius:calc(0rem * var(--corner-multiplier));border-bottom-left-radius:calc(0rem * var(--corner-multiplier));border-bottom-right-radius:calc(0rem * var(--corner-multiplier));--media-width:900px;--media-height:601px"> <div class="Lazyload__loading" aria-hidden="true"> <div class="Display--none Display--md-block"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgOTAwIDYwMSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB3aWR0aD0iOTAwIiBoZWlnaHQ9IjYwMSI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSI+PC9yZWN0Pjwvc3ZnPg=="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> <div class="Display--md-none"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgOTAwIDYwMSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB3aWR0aD0iOTAwIiBoZWlnaHQ9IjYwMSI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSI+PC9yZWN0Pjwvc3ZnPg=="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> </div> <div data-lazyload-item="true" class="FullSize"> <picture> <source media="(min-width: 901px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/lsG7VJAVdu/scientists-in-discussion-during-hca-launch-meeting-2016-10-london-_-credit-human-cell-atlas-900x601.jpg"> <source media="(max-width: 900px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/lsG7VJAVdu/scientists-in-discussion-during-hca-launch-meeting-2016-10-london-_-credit-human-cell-atlas-900x601.jpg"><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/lsG7VJAVdu/scientists-in-discussion-during-hca-launch-meeting-2016-10-london-_-credit-human-cell-atlas-900x601.jpg" alt=""> </picture> </div> </div> <figcaption class="Theme-Caption Theme-InlineMediaCaption"> <div class="Display--none Display--md-block"> <p class="">Scientists at the launch meeting in 2016 (Human Cell Atlas)</p> </div> <div class="Display--md-none"> <p class="">Scientists at the launch meeting in 2016 (Human Cell Atlas)</p> </div> </figcaption> </figure> <p class="MsoNormal">“Within a couple of weeks of the beginning of the pandemic, the whole Human Cell Atlas community pulled together and everybody shared data that was published and unpublished, and mapped where the SARS-CoV-2 virus was docking,” says Teichmann. “It showed that the virus could enter through cells in the eyes, nose and mouth.”</p> <p class="MsoNormal">This information was reported to the government’s Scientific Advisory Group for Emergencies (SAGE) committee, helping inform how it responded to the virus, such as implementing policies around mask-wearing.</p> <p class="MsoNormal">Although it has become something of a cliché for scientists to describe their project as a ‘Google Map for X’, in this case it seems wholly suitable.</p> <p class="MsoNormal">“You can use the Human Cell Atlas as a sort of Google Maps of the molecules and cells in the human body, because you can find out how a virus could enter the body and how it can move around inside from tissue to tissue. It was an exciting learning curve during the pandemic, and a really proud moment for the Human Cell Atlas community. It illustrates the reason why we need a map of the healthy human body.”</p> <p class="MsoNormal">The willingness to share data both within the HCA community and more widely is fundamental to the entire project. Any research group can join the community, says Teichmann. “It’s completely open – any researcher from any country is welcome to join.” The only requirement is that they sign up to the project’s ethical principles and commitment to open data sharing.</p> <figure class="InlineMedia InlineMedia--image media-size-100" data-lazyload-container="true" data-lazyload-trigger="true"> <div class="InlineMedia--image__inner crop-uncropped" style="overflow:hidden;border-top-left-radius:calc(0rem * var(--corner-multiplier));border-top-right-radius:calc(0rem * var(--corner-multiplier));border-bottom-left-radius:calc(0rem * var(--corner-multiplier));border-bottom-right-radius:calc(0rem * var(--corner-multiplier));--media-width:900px;--media-height:469px"> <div class="Lazyload__loading" aria-hidden="true"> <div class="Display--none Display--md-block"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgOTAwIDQ2OSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB3aWR0aD0iOTAwIiBoZWlnaHQ9IjQ2OSI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSI+PC9yZWN0Pjwvc3ZnPg=="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> <div class="Display--md-none"><img alt="" src="data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgOTAwIDQ2OSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB3aWR0aD0iOTAwIiBoZWlnaHQ9IjQ2OSI+PHJlY3Qgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSI+PC9yZWN0Pjwvc3ZnPg=="> <div class="Lazyload__spiner Theme-Lazyload-Spinner"></div> </div> </div> <div data-lazyload-item="true" class="FullSize"> <picture> <source media="(min-width: 901px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/1T4kTdEByh/attendees-at-hca-asia-meeting-kolkata-india-2023-11-_credit-human-cell-atlas-900x469.jpg"> <source media="(max-width: 900px)" data-srcset="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/1T4kTdEByh/attendees-at-hca-asia-meeting-kolkata-india-2023-11-_credit-human-cell-atlas-900x469.jpg"><img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/1T4kTdEByh/attendees-at-hca-asia-meeting-kolkata-india-2023-11-_credit-human-cell-atlas-900x469.jpg" alt=""> </picture> </div> </div> <figcaption class="Theme-Caption Theme-InlineMediaCaption"> <div class="Display--none Display--md-block"> <p class="">Attendees at HCA Asia Meeting in India in 2023 (Human Cell Atlas)</p> </div> <div class="Display--md-none"> <p class="">Attendees at HCA Asia Meeting in India in 2023 (Human Cell Atlas)</p> </div> </figcaption> </figure> <p class="MsoNormal">The international consortium is crucial to delivering on the promise of the HCA. As Teichmann points out, “It’s a huge project and requires a lot of people to work together”. But there is another reason by she encourages scientists from every corner of the globe to participate.</p> <p class="MsoNormal">“[The HCA] is an underpinning resource for science and humanity, and so we felt it was appropriate to have it be a global project that's open for everyone to join and that's inclusive of the whole international scientific community. That also means the samples that we study will come from patients and donors from all over the world, so it will be more representative of humankind.”</p> <p class="MsoNormal">The studies published today are not, of course, the first to emerge from the project – and nor will they be the last. There is still a lot of work to be done, for example to map some missing tissues across head, thoracic, abdominal and peripheral structures of the body, and then to assemble all the data sets together into a spatially-resolved complete atlas.</p> <p class="MsoNormal">“I'm incredibly proud of what we've achieved by working together,” says Teichmann. “It's been eight years and over that time, a number of young researchers have risen up and developed their careers. The community and the culture that we've all built together has been very special and different. It’s been supportive and collaborative and inclusive.</p> <h4 class="Theme-Layer-BodyText-Heading-xs MsoNormal Theme-TextSize-xxxsmall"><span class="Theme-ForegroundColor-0">"I'm super proud of how much we've achieved. It’s been mind-blowing, such an exciting journey."</span></h4> <p class=""><span class="Theme-ForegroundColor-0"><sup><strong>Sarah Teichmann</strong></sup></span></p> <div class="InlineElement InlineElement--Divider__container"> <hr aria-hidden="true" class="Theme-Layer-BodyText-Divider Theme-DividerSize-medium Theme-BackgroundColor-0"> </div> </div> <div class="FullSize Theme-Overlay" style="opacity:0"></div> </div> </div> </div> </div> </div> </div> <div id="section-PGMODUymZq" class="Theme-Section Theme-TextSection Theme-Section-Position-11 Theme-Section-Layout--Full Theme-Section-Light Theme-BodyTextColumn-Left Theme-Columns--2" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layer--one"> <div class="Layout"> <div class="Layout__row"> <div class="Layout__col Layout__col-lg-6 Layout__offset-lg-0 Layout__col-md-6 Layout__offset-md-0 Layout__col-sm-10 Layout__offset-sm-0 Layout__col-xs-12 Layout__offset-xs-0 Theme-Column"> <div class="Theme-Layer-BodyText"> <div class="Theme-Layer-BodyText--inner"> <p class=""><span class="Theme-ForegroundColor-0"><sup><strong>Published on 20 November 2024</strong></sup></span></p> <p class=""><span class="Theme-ForegroundColor-0"><sup>The Human Cell Atlas has received diverse collaborative support from multiple funders from around the world. Funders of these papers include the Chan Zuckerberg Initiative, Wellcome Trust, NIH, National Key R&D Program of China, National Natural Science Foundation of China, UK Medical Research Council, European Research Council under the European Union’s Horizon 2020 research and innovation program, Canadian Institutes of Health Research, the National Institute for Health and Care Research. The HCA also receives organisational support from CZI, Wellcome, the Klarman Family Foundation, and the Helmsley Charitable Trust, among others.</sup></span></p> </div> <div class="FullSize Theme-Overlay" style="opacity:0"></div> </div> </div> <div class="Layout__col Layout__col-lg-6 Layout__offset-lg-0 Layout__col-md-6 Layout__offset-md-0 Layout__col-sm-10 Layout__offset-sm-0 Layout__col-xs-12 Layout__offset-xs-0 Theme-Column"> <div class="Theme-Layer-BodyText"> <div class="Theme-Layer-BodyText--inner"> <p class=""><sup><strong>Images</strong></sup></p> <ul class="Theme-Layer-BodyText-List-Unordered Theme-TextSize-default"><li class="Theme-Layer-BodyText-ListItem"><sup>Main image and sub-header images courtesy of Aviv Regev and Ania Hupalowska</sup></li><li class="Theme-Layer-BodyText-ListItem"><sup>Sarah Teichmann by Lloyd Mann</sup></li> </ul> <p class=""><sub>The text in this work is licensed under a </sub><span data-footnote="%3Cp%20class%3D%22%22%3EImages%2C%20including%20our%20videos%2C%20are%20Copyright%20%C2%A9University%20of%20Cambridge%20and%20licensors%2Fcontributors%20as%20identified.%C2%A0%20All%20rights%20reserved.%20We%20make%20our%20image%20and%20video%20content%20available%20in%20a%20number%20of%20ways%20%E2%80%93%20as%20here%2C%20on%20our%20%3Ca%20href%3D%22https%3A%2F%2Fwww.cam.ac.uk%2F%22%3Emain%20website%3C%2Fa%3E%20under%20its%20%3Ca%20href%3D%22https%3A%2F%2Fwww.cam.ac.uk%2Fabout-this-site%2Fterms-and-conditions%22%3ETerms%20and%20conditions%3C%2Fa%3E%2C%20and%20on%20a%20%3Ca%20href%3D%22https%3A%2F%2Fwww.cam.ac.uk%2Fabout-this-site%2Fconnect-with-us%22%3Erange%20of%20channels%20including%20social%20media%3C%2Fa%3E%20that%20permit%20your%20use%20and%20sharing%20of%20our%20content%20under%20their%20respective%20Terms.%3C%2Fp%3E" class="Theme-Layer-BodyText-Highlight"><span><a href="http://creativecommons.org/licenses/by/4.0/" target="_blank"><span class="Theme-ForegroundColor-14"><sub>Creative Commons Attribution 4.0 International License</sub></span></a></span><span aria-hidden="true" class="Theme-Layer-BodyText-Highlight--Icon"></span></span></p> <p class=""><sup>Highlights from the Collection text by Samantha Wynne, Human Cell Atlas</sup></p> </div> <div class="FullSize Theme-Overlay" style="opacity:0"></div> </div> </div> </div> </div> </div> </div> <div id="section-9ELdZGeJDV" class="Theme-Section Theme-CollectionSectionSection Theme-Section-Position-12 Theme-Section-Layout--Full Theme-Section-Light Theme-Section-HasOverlay" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layer--one Theme-Collection--Default Theme-Collection--Medium Theme-Layer-Gallery GalleryRenderer--initializing" data-galleryrenderer="true" data-url="https://data.shorthand.com/Byt2mkeKrW/collections/zbHsiV3jFO/items.json" data-mode="default"></div> <div class="Layer--two FullSize FullSize--scrollChild FullSize--child Theme-BackgroundMedia Theme-BackgroundImage"> <div data-lazyload-container="true" data-lazyload-trigger="true" class="FullSize--fullWidth FullSize--fullHeight Core--pointerEventsNone Lazyload Lazyload--isLoading"> <div class="FullSize Lazyload__loading" aria-hidden="true"></div> <div data-lazyload-item="true" class="FullSize"> <picture class="FullSize--fullWidth FullSize--fullHeight FullSize--scrollChild Theme-Item-Picture" data-landscape-focal="50% 50%" data-portrait-focal="50% 50%"><img class="FullSize FullSize--fullWidth FullSize--fullHeight ObjectFit--cover" data-src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/templates/set-b/placeholders/transparent.png" alt="" style="object-position:50% 50%"></picture> </div> </div> <div class="FullSize Theme-Overlay Theme-Section-Light" style="opacity:0"></div> </div> </div> <div data-testid="StandardFooter" id="StandardFooter" data-footer="standard" class="Theme-Footer FullSize--fullWidth"> <div class="Layout FullSize--fullHeight"><a id="61cYmgFyRP-footerTopLink" href="#article" class="Layout__snap--xcenter Layout__snap--ycenter Theme-FooterTopLink">Top</a><a href="https://shorthand.com/?utm_source=__host__&utm_medium=referral&utm_campaign=footer&utm_term=built+with+shorthand&utm_content=61cYmgFyRP" class="Layout__snap--xright Theme-FooterLogo--container" rel="noopener noreferrer" title="The beautifully simple way to build brand and feature stories for the web." target="_blank" id="61cYmgFyRP-footer_shorthand_link"><img id="FooterLogo" src="https://www.cam.ac.uk/sites/default/files/shorthand/248566/61cYmgFyRP/assets/logo-black-no-text.svg" alt="Shorthand logo" class="Theme-FooterLogo">Built with <strong translate="no">Shorthand</strong></a></div> </div> </article> <script> window.$sha = { "storyId": "61cYmgFyRP", "storyVersion": "747", "orgId": "Byt2mkeKrW", "trackTime": true, "endpoint": "https://gateway.shorthand.com/analytics/story", "isTestStory": false, "isPreview": false }; 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