Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

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To determine the prevalence of mutations in other tumor types, we evaluated 759 malignant neoplasms including those of the pancreas, breast, colon, stomach, lung, …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/22009941/"><meta name="twitter:description" content="Mutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas (OCCCs). To determine the prevalence of mutations in other tumor types, we evaluated 759 malignant neoplasms including those of the pancreas, breast, colon, stomach, lung, …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">  <link rel="search" type="application/opensearchdescription+xml" href="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/opensearch.xml" title="PubMed search">  <noscript> <link rel="stylesheet" type="text/css" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/core/no-script.css"> </noscript> <meta name="citation_title" content="Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types"> <meta name="citation_authors" content="Jones S;Li M;Parsons DW;Zhang X;Wesseling J;Kristel P;Schmidt MK;Markowitz S;Yan H;Bigner D;Hruban RH;Eshleman JR;Iacobuzio-Donahue CA;Goggins M;Maitra A;Malek SN;Powell S;Vogelstein B;Kinzler KW;Velculescu VE;Papadopoulos N;"> <meta name="citation_date" content="2012 Jan"> <meta name="citation_publisher" content="Hum Mutat"> <meta name="citation_journal_title" content="Human mutation"> <meta name="citation_pmid" content="22009941"> <meta name="citation_abstract_html_url" content="https://pubmed.ncbi.nlm.nih.gov/22009941/"> <meta name="citation_volume" content="33"> <meta name="citation_issue" content="1"> <meta name="citation_doi" content="10.1002/humu.21633"> <meta name="citation_issn" content="1098-1004"> <link rel="canonical" href="https://pubmed.ncbi.nlm.nih.gov/22009941/" /> </head> <body > <noscript> <div class="no-script-banner" id="no-script-banner"> <div class="warning-message"> <div class="warning-message-text"> This site needs JavaScript to work properly. 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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="6JgJC5isRBtPS0lqsay6gmmEa5fsxXUE3qrgia3JWOC2MW6uhqAtFc1AN6wEzwGO"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="6JgJC5isRBtPS0lqsay6gmmEa5fsxXUE3qrgia3JWOC2MW6uhqAtFc1AN6wEzwGO"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="6JgJC5isRBtPS0lqsay6gmmEa5fsxXUE3qrgia3JWOC2MW6uhqAtFc1AN6wEzwGO"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="6JgJC5isRBtPS0lqsay6gmmEa5fsxXUE3qrgia3JWOC2MW6uhqAtFc1AN6wEzwGO"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="22009941"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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value="6JgJC5isRBtPS0lqsay6gmmEa5fsxXUE3qrgia3JWOC2MW6uhqAtFc1AN6wEzwGO"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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</button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Human mutation"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Hum+Mutat%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Hum+Mutat%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Hum Mutat" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Hum Mutat"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Hum+Mutat%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Hum Mutat"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Hum Mutat"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Hum Mutat"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2012 Jan;33(1):100-3.</span> </div> <span class="citation-doi"> doi: 10.1002/humu.21633. </span> <span class="secondary-date"> Epub 2011 Nov 23. </span> </div> <h1 class="heading-title"> Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Jones+S&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Siân Jones">Siân Jones</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Li+M&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Meng Li">Meng Li</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Parsons+DW&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="D Williams Parsons">D Williams Parsons</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+X&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Xiaosong Zhang">Xiaosong Zhang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wesseling+J&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jelle Wesseling">Jelle Wesseling</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kristel+P&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Petra Kristel">Petra Kristel</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schmidt+MK&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Marjanka K Schmidt">Marjanka K Schmidt</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Markowitz+S&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sanford Markowitz">Sanford Markowitz</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yan+H&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hai Yan">Hai Yan</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bigner+D&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Darell Bigner">Darell Bigner</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hruban+RH&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ralph H Hruban">Ralph H Hruban</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Eshleman+JR&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="James R Eshleman">James R Eshleman</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Iacobuzio-Donahue+CA&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christine A Iacobuzio-Donahue">Christine A Iacobuzio-Donahue</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Goggins+M&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michael Goggins">Michael Goggins</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Maitra+A&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Anirban Maitra">Anirban Maitra</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Malek+SN&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sami N Malek">Sami N Malek</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Powell+S&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Steve Powell">Steve Powell</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Vogelstein+B&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bert Vogelstein">Bert Vogelstein</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kinzler+KW&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kenneth W Kinzler">Kenneth W Kinzler</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Velculescu+VE&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Victor E Velculescu">Victor E Velculescu</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Papadopoulos+N&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nickolas Papadopoulos">Nickolas Papadopoulos</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/22009941/long-authors/" data-id-prefix=""> 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href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3240719/" data-ga-category="full_text" data-ga-action="PMCID" > PMC3240719 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1002/humu.21633&id_type=DOI" href="https://doi.org/10.1002/humu.21633" data-ga-category="full_text" data-ga-action="DOI" > 10.1002/humu.21633 </a> </span> </li> </ul> <span class="free-label">Free PMC article</span> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <div class="publication-type" >Multicenter Study</div> <h1 class="heading-title"> Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Siân Jones</span><span class="citation-separator"> et 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dropdown-container" hidden aria-label="Dropdown menu for journal Human mutation"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Hum+Mutat%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Hum+Mutat%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Hum Mutat" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Hum Mutat"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Hum+Mutat%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Hum Mutat"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Hum Mutat"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Hum Mutat"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2012 Jan;33(1):100-3.</span> </div> <span class="citation-doi"> doi: 10.1002/humu.21633. </span> <span class="secondary-date"> Epub 2011 Nov 23. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Jones+S&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Siân Jones">Siân Jones</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Li+M&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Meng Li">Meng Li</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Parsons+DW&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="D Williams Parsons">D Williams Parsons</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+X&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Xiaosong Zhang">Xiaosong Zhang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wesseling+J&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jelle Wesseling">Jelle Wesseling</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kristel+P&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Petra Kristel">Petra Kristel</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schmidt+MK&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Marjanka K Schmidt">Marjanka K Schmidt</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Markowitz+S&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sanford Markowitz">Sanford Markowitz</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yan+H&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hai Yan">Hai Yan</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bigner+D&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Darell Bigner">Darell Bigner</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hruban+RH&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ralph H Hruban">Ralph H Hruban</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Eshleman+JR&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="James R Eshleman">James R Eshleman</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Iacobuzio-Donahue+CA&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christine A Iacobuzio-Donahue">Christine A Iacobuzio-Donahue</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Goggins+M&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michael Goggins">Michael Goggins</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Maitra+A&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Anirban Maitra">Anirban Maitra</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Malek+SN&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sami N Malek">Sami N Malek</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Powell+S&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Steve Powell">Steve Powell</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Vogelstein+B&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bert Vogelstein">Bert Vogelstein</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kinzler+KW&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kenneth W Kinzler">Kenneth W Kinzler</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Velculescu+VE&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Victor E Velculescu">Victor E Velculescu</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Papadopoulos+N&cauthor_id=22009941" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nickolas Papadopoulos">Nickolas Papadopoulos</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">22009941</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC3240719&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3240719/" data-ga-category="full_text" data-ga-action="PMCID" > PMC3240719 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1002/humu.21633&id_type=DOI" href="https://doi.org/10.1002/humu.21633" data-ga-category="full_text" data-ga-action="DOI" > 10.1002/humu.21633 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/22009941/citations/" data-citation-style="nlm" data-pubmed-format-link="/22009941/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Mutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas (OCCCs). To determine the prevalence of mutations in other tumor types, we evaluated 759 malignant neoplasms including those of the pancreas, breast, colon, stomach, lung, prostate, brain, and blood (leukemias). We identified truncating mutations in 6% of the neoplasms studied; nontruncating somatic mutations were identified in an additional 0.4% of neoplasms. Mutations were most commonly found in gastrointestinal samples with 12 of 119 (10%) colorectal and 10 of 100 (10%) gastric neoplasms, respectively, harboring changes. More than half of the mutated colorectal and gastric cancers displayed microsatellite instability (MSI) and the mutations in these tumors were out-of-frame insertions or deletions at mononucleotide repeats. Mutations were also identified in 2-8% of tumors of the pancreas, breast, brain (medulloblastomas), prostate, and lung, and none of these tumors displayed MSI. These findings suggest that the aberrant chromatin remodeling consequent to ARID1A inactivation contributes to a variety of different types of neoplasms. </p> </div> </div> <p class="copyright" id="copyright"> © 2011 Wiley Periodicals, Inc. </p> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac4/3558803/83963b1a8754/humu0033-0100-f1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="720" data-image-height="610" data-image-alt="Figure 1" data-pmc-id="PMC3240719" data-figure-id="fig01"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ac4/3558803/db45b3fef90e/humu0033-0100-f1.gif" alt="Figure 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="720"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="610"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> A: Examples of truncating mutations… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> A: Examples of truncating mutations in <i> ARID1A </i> in gastric, colon, breast, and pancreatic… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1 </strong> <div class="figure-caption-contents">A: Examples of truncating mutations in <i>ARID1A</i> in gastric, colon, breast, and pancreatic cancers. Arrows indicate the position of the mutation. Note that in the breast primary tumor (399), there were contaminating nonneoplastic cells that reduced the relative peak heights of the mutant alleles. B: Distribution and types of mutations identified in <i>ARID1A</i> to date. Exons are indicated in blue with the ARID (AT-rich interactive domain), DNA-binding domain shown in green, the HIC (hypermethylated in cancer) domain in purple, and the LXXLL (leucine rich) motifs in pink. Black arrows indicate the position of insertion or deletion mutations, red arrows indicate nonsense mutations, blue arrows indicate missense variants, and gray arrows indicate splice site alterations. Mutations listed above the figure represent those reported in this study; those below were identified in Jones et al. [2010] and Wiegand et al. [2010] in ovarian cancers; Gui et al. [2011] in bladder cancer; Varela et al. in renal cancer, and Birnbaum et al. in pancreatic cancer.</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/23030715/" ref="article_id=23030715&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="23030715" data-ga-label=""> Frameshift mutations of a chromatin-remodeling gene SMARCC2 in gastric and colorectal cancers with microsatellite instability. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Kim SS, Kim MS, Yoo NJ, Lee SH.</span> <span class="docsum-authors short-authors">Kim SS, et al.</span> <span class="docsum-journal-citation full-journal-citation">APMIS. 2013 Feb;121(2):168-9. doi: 10.1111/j.1600-0463.2012.02953.x. 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Genes Chromosomes Cancer. 2007;46:745–750. - <a class="reference-link" href="/17492758/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="17492758" > PubMed </a> </li> </ol> </li> </ol> <div class="actions-bar"> <button class="show-all" ref="linksrc=show_all_references_link" aria-controls="top-references-list-1" data-next-page-url="/22009941/references/" data-ga-category="reference" data-ga-action="show_more" > Show all 27 references </button> </div> </div> </div> </div> <div id="publication-types" class="publication-types keywords-section"> <h2 class="title"> Publication types </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Multicenter Study" tabindex="0" aria-controls="keyword-actions-publication-types-0" aria-expanded="false" data-pinger-ignore> Multicenter Study </button><div id="keyword-actions-publication-types-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Multicenter Study"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Multicenter+Study%22%5Bpt%5D&sort=date&sort_order=desc" data-href="/?term=%22Multicenter+Study%22%5Bpt%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Multicenter Study"[pt]" data-ga-category="search" data-ga-action="pub_type" data-ga-label="Multicenter Study"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Multicenter+Study" data-ga-category="search_mesh" data-ga-action="pub_type_link" data-ga-label="Multicenter Study"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Multicenter Study"[pt]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Multicenter Study"[pt]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Research Support, N.I.H., Extramural" tabindex="0" aria-controls="keyword-actions-publication-types-1" aria-expanded="false" data-pinger-ignore> Research Support, N.I.H., Extramural </button><div id="keyword-actions-publication-types-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Research Support, N.I.H., Extramural"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Research+Support%2C+N.I.H.%2C+Extramural%22%5Bpt%5D&sort=date&sort_order=desc" data-href="/?term=%22Research+Support%2C+N.I.H.%2C+Extramural%22%5Bpt%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Research Support, N.I.H., Extramural"[pt]" data-ga-category="search" data-ga-action="pub_type" data-ga-label="Research Support, N.I.H., Extramural"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Research+Support%2C+N.I.H.%2C+Extramural" data-ga-category="search_mesh" data-ga-action="pub_type_link" data-ga-label="Research Support, N.I.H., Extramural"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Research Support, N.I.H., Extramural"[pt]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Research Support, N.I.H., 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class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Adenocarcinoma, Clear Cell / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-0" aria-expanded="false" data-pinger-ignore> Adenocarcinoma, Clear Cell / genetics* </button><div id="keyword-actions-mesh-terms-major-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Adenocarcinoma, Clear Cell / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Adenocarcinoma%2C+Clear+Cell%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Adenocarcinoma%2C+Clear+Cell%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Adenocarcinoma, Clear Cell/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" 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aria-expanded="false" data-pinger-ignore> Adenocarcinoma, Clear Cell / pathology </button><div id="keyword-actions-mesh-terms-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Adenocarcinoma, Clear Cell / pathology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Adenocarcinoma%2C+Clear+Cell%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Adenocarcinoma%2C+Clear+Cell%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Adenocarcinoma, Clear Cell/pathology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Adenocarcinoma, Clear Cell / pathology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Adenocarcinoma%2C+Clear+Cell" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Adenocarcinoma, Clear Cell / pathology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Adenocarcinoma, Clear Cell/pathology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Adenocarcinoma, Clear Cell/pathology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Base Sequence" tabindex="0" aria-controls="keyword-actions-mesh-terms-2" aria-expanded="false" data-pinger-ignore> Base Sequence </button><div id="keyword-actions-mesh-terms-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Base Sequence"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Base+Sequence%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Base+Sequence%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Base Sequence"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Base Sequence"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Base+Sequence" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Base Sequence"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Base Sequence"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Base Sequence"[MeSH]" href="#"> 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data-ga-action="add_to_search" data-ga-label=""Breast/pathology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Chromatin / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-5" aria-expanded="false" data-pinger-ignore> Chromatin / genetics* </button><div id="keyword-actions-mesh-terms-major-5" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Chromatin / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Chromatin%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Chromatin%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" 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class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Chromatin+Assembly+and+Disassembly%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Chromatin+Assembly+and+Disassembly%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Chromatin Assembly and Disassembly"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Chromatin Assembly and Disassembly"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Chromatin+Assembly+and+Disassembly" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Chromatin Assembly and Disassembly"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Chromatin Assembly and Disassembly"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" 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class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Colon / pathology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Colon%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Colon%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Colon/pathology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Colon / pathology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Colon" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Colon / pathology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Colon/pathology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Colon/pathology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Colorectal Neoplasms / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-10" aria-expanded="false" data-pinger-ignore> Colorectal Neoplasms / genetics* </button><div id="keyword-actions-mesh-terms-major-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Colorectal Neoplasms / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Colorectal+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Colorectal+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Colorectal Neoplasms/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Colorectal Neoplasms / genetics*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Colorectal Neoplasms / genetics*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Colorectal Neoplasms/genetics"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Colorectal Neoplasms/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Colorectal Neoplasms / pathology" tabindex="0" aria-controls="keyword-actions-mesh-terms-11" aria-expanded="false" data-pinger-ignore> Colorectal Neoplasms / pathology </button><div id="keyword-actions-mesh-terms-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Colorectal Neoplasms / pathology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Colorectal+Neoplasms%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Colorectal+Neoplasms%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Colorectal Neoplasms/pathology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Colorectal Neoplasms / pathology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Colorectal Neoplasms / pathology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Colorectal Neoplasms/pathology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Colorectal Neoplasms/pathology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword DNA-Binding Proteins" tabindex="0" aria-controls="keyword-actions-mesh-terms-12" aria-expanded="false" data-pinger-ignore> DNA-Binding Proteins </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword DNA-Binding Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22DNA-Binding+Proteins%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22DNA-Binding+Proteins%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="DNA-Binding Proteins"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="DNA-Binding Proteins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=DNA-Binding+Proteins" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="DNA-Binding Proteins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""DNA-Binding Proteins"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""DNA-Binding Proteins"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Female" tabindex="0" aria-controls="keyword-actions-mesh-terms-13" aria-expanded="false" data-pinger-ignore> Female </button><div id="keyword-actions-mesh-terms-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Female"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Female"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Female"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Female" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Female"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Female"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Female"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Frameshift Mutation*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-14" aria-expanded="false" data-pinger-ignore> Frameshift Mutation* </button><div id="keyword-actions-mesh-terms-major-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Frameshift Mutation*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Frameshift+Mutation%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Frameshift+Mutation%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Frameshift Mutation"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Frameshift Mutation*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Frameshift+Mutation" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Frameshift Mutation*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Frameshift Mutation"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Frameshift Mutation"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Gastric Mucosa / metabolism" tabindex="0" aria-controls="keyword-actions-mesh-terms-15" aria-expanded="false" data-pinger-ignore> Gastric Mucosa / metabolism </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Gastric Mucosa / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Gastric+Mucosa%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Gastric+Mucosa%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Gastric Mucosa/metabolism"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Gastric Mucosa / metabolism"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Gastric+Mucosa" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Gastric Mucosa / metabolism"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Gastric Mucosa/metabolism"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Gastric Mucosa/metabolism"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-16" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Humans"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Humans"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Humans"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Humans"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Male" tabindex="0" aria-controls="keyword-actions-mesh-terms-17" aria-expanded="false" data-pinger-ignore> Male </button><div id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Male"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Male"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Male"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Male" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Male"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Male"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Male"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Microsatellite Instability" tabindex="0" aria-controls="keyword-actions-mesh-terms-18" aria-expanded="false" data-pinger-ignore> Microsatellite Instability </button><div id="keyword-actions-mesh-terms-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Microsatellite Instability"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Microsatellite+Instability%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Microsatellite+Instability%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Microsatellite Instability"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Microsatellite Instability"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Microsatellite+Instability" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Microsatellite Instability"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Microsatellite Instability"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Microsatellite Instability"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Microsatellite Repeats" tabindex="0" aria-controls="keyword-actions-mesh-terms-19" aria-expanded="false" data-pinger-ignore> Microsatellite Repeats </button><div id="keyword-actions-mesh-terms-19" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Microsatellite Repeats"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Microsatellite+Repeats%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Microsatellite+Repeats%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Microsatellite Repeats"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Microsatellite Repeats"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Microsatellite+Repeats" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Microsatellite Repeats"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Microsatellite Repeats"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Microsatellite Repeats"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Molecular Sequence Data" tabindex="0" aria-controls="keyword-actions-mesh-terms-20" aria-expanded="false" data-pinger-ignore> Molecular Sequence Data </button><div id="keyword-actions-mesh-terms-20" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Molecular Sequence Data"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Molecular+Sequence+Data%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Molecular+Sequence+Data%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Molecular Sequence Data"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Molecular Sequence Data"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Molecular+Sequence+Data" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Molecular Sequence Data"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Molecular Sequence Data"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Molecular Sequence Data"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Nuclear Proteins / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-21" aria-expanded="false" data-pinger-ignore> Nuclear Proteins / genetics* </button><div id="keyword-actions-mesh-terms-major-21" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Nuclear Proteins / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Nuclear+Proteins%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Nuclear+Proteins%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Nuclear Proteins/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Nuclear Proteins / genetics*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Nuclear+Proteins" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Nuclear Proteins / genetics*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Nuclear Proteins/genetics"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Nuclear Proteins/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Pancreas / metabolism" tabindex="0" aria-controls="keyword-actions-mesh-terms-22" aria-expanded="false" data-pinger-ignore> Pancreas / metabolism </button><div id="keyword-actions-mesh-terms-22" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Pancreas / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Pancreas%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Pancreas%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Pancreas/metabolism"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Pancreas / metabolism"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Pancreas" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Pancreas / metabolism"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Pancreas/metabolism"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Pancreas/metabolism"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Pancreas / pathology" tabindex="0" aria-controls="keyword-actions-mesh-terms-23" aria-expanded="false" data-pinger-ignore> Pancreas / pathology </button><div id="keyword-actions-mesh-terms-23" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Pancreas / pathology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Pancreas%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Pancreas%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Pancreas/pathology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Pancreas / pathology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Pancreas" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Pancreas / pathology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Pancreas/pathology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Pancreas/pathology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Stomach / pathology" tabindex="0" aria-controls="keyword-actions-mesh-terms-24" aria-expanded="false" data-pinger-ignore> Stomach / pathology </button><div id="keyword-actions-mesh-terms-24" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Stomach / pathology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Stomach%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Stomach%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Stomach/pathology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Stomach / pathology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Stomach" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Stomach / pathology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Stomach/pathology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Stomach/pathology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Stomach Neoplasms / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-25" aria-expanded="false" data-pinger-ignore> Stomach Neoplasms / genetics* </button><div id="keyword-actions-mesh-terms-major-25" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Stomach Neoplasms / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Stomach+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Stomach+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Stomach Neoplasms/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Stomach Neoplasms 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id="related-links" class="related-links"> <h2 class="title"> Related information </h2> <ul class="related-links-list"><li><a title="Clinical variations associated with publication" href="https://www.ncbi.nlm.nih.gov/clinvar?linkname=pubmed_clinvar&from_uid=22009941" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=22009941&ordinalpos=1&linkpos=1"> ClinVar </a></li><li><a title="Link to related CDD entry" href="https://www.ncbi.nlm.nih.gov/cdd?linkname=pubmed_cdd&from_uid=22009941" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=22009941&ordinalpos=1&linkpos=2"> Domains </a></li><li><a title="Link to related Genes" href="https://www.ncbi.nlm.nih.gov/gene?linkname=pubmed_gene&from_uid=22009941" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=22009941&ordinalpos=1&linkpos=3"> Gene </a></li><li><a title="Link to Gene for the GeneRIF subcategory" href="https://www.ncbi.nlm.nih.gov/gene?linkname=pubmed_gene_rif&from_uid=22009941" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=22009941&ordinalpos=1&linkpos=4"> Gene (GeneRIF) </a></li><li><a title="Related information in MedGen" href="https://www.ncbi.nlm.nih.gov/medgen?linkname=pubmed_medgen&from_uid=22009941" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=22009941&ordinalpos=1&linkpos=5"> MedGen </a></li><li><a title="Published protein sequences" href="https://www.ncbi.nlm.nih.gov/protein?linkname=pubmed_protein&from_uid=22009941" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=22009941&ordinalpos=1&linkpos=6"> Protein </a></li><li><a title="Link to Protein RefSeqs" href="https://www.ncbi.nlm.nih.gov/protein?linkname=pubmed_protein_refseq&from_uid=22009941" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=22009941&ordinalpos=1&linkpos=7"> Protein (RefSeq) </a></li></ul> </div> <div id="grants" class="grants"> <h2 class="title"> Grants and funding </h2> <div class="grants-list"><ul id="grants-head-list"><li class="grant-item"><a title="All articles for grant 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Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types - PubMed