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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Molecular Imaging</h1><div class="u-tcGrayDark">10,602 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Molecular Imaging</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Molecular_Imaging">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Molecular_Imaging/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Molecular_Imaging/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Molecular_Imaging/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Molecular_Imaging">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15955864" data-work_id="15955864" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15955864/Molecular_imaging_of_hypoxia_with_radiolabelled_agents">Molecular imaging of hypoxia with radiolabelled agents</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biological functions. Structural and functional abnormalities of the tumour vasculature together with altered diffusion conditions inside the tumour seem to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15955864" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biological functions. Structural and functional abnormalities of the tumour vasculature together with altered diffusion conditions inside the tumour seem to be the main causes of tumour hypoxia. Evidence from experimental and clinical studies points to a role for tumour hypoxia in tumour propagation, resistance to therapy and malignant</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15955864" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="eb962a87af5c30f121f46e0adbd27fd3" rel="nofollow" data-download="{"attachment_id":42814315,"asset_id":15955864,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42814315/download_file?st=MTczMjk5NjMzOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35111225" href="https://independent.academia.edu/ChristelVangestel">Christel Vangestel</a><script data-card-contents-for-user="35111225" type="text/json">{"id":35111225,"first_name":"Christel","last_name":"Vangestel","domain_name":"independent","page_name":"ChristelVangestel","display_name":"Christel Vangestel","profile_url":"https://independent.academia.edu/ChristelVangestel?f_ri=39857","photo":"https://0.academia-photos.com/35111225/10210169/11394063/s65_christel.vangestel.jpg"}</script></span></span></li><li class="js-paper-rank-work_15955864 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15955864"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15955864, container: ".js-paper-rank-work_15955864", }); 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imaging</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Dedicated and specialized radiofrequency coils are critical for high quality musculoskeletal magnetic resonance imaging (MRI). Dedicated coils improve the signal to noise ratio, allowing for faster or higher resolution examinations.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25932604" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dedicated and specialized radiofrequency coils are critical for high quality musculoskeletal magnetic resonance imaging (MRI). Dedicated coils improve the signal to noise ratio, allowing for faster or higher resolution examinations. Transmit-receive coils can reduce heating at high field strength. Finally, novel radiofrequency coils can be used for assessment of tissue biochemistry, as seen with sodium MRI.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25932604" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="93329147ba478aaf417e77f7f2745d11" rel="nofollow" data-download="{"attachment_id":46289363,"asset_id":25932604,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46289363/download_file?st=MTczMjk5NjMzOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="49727227" href="https://independent.academia.edu/NealBangerter">Neal Bangerter</a><script data-card-contents-for-user="49727227" type="text/json">{"id":49727227,"first_name":"Neal","last_name":"Bangerter","domain_name":"independent","page_name":"NealBangerter","display_name":"Neal Bangerter","profile_url":"https://independent.academia.edu/NealBangerter?f_ri=39857","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25932604 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25932604"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25932604, container: ".js-paper-rank-work_25932604", }); 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data-has-card-for-ri="140" href="https://www.academia.edu/Documents/in/Pharmacology">Pharmacology</a>, <script data-card-contents-for-ri="140" type="text/json">{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="300" href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a>, <script data-card-contents-for-ri="300" type="text/json">{"id":300,"name":"Mathematics","url":"https://www.academia.edu/Documents/in/Mathematics?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="498" href="https://www.academia.edu/Documents/in/Physics">Physics</a>, <script data-card-contents-for-ri="498" type="text/json">{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2513" 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Bradbury","profile_url":"https://mskcc.academia.edu/MichelleBradbury?f_ri=39857","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology?f_ri=39857","nofollow":false},{"id":300,"name":"Mathematics","url":"https://www.academia.edu/Documents/in/Mathematics?f_ri=39857","nofollow":false},{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics?f_ri=39857","nofollow":false},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology?f_ri=39857","nofollow":false},{"id":10035,"name":"Nuclear medicine","url":"https://www.academia.edu/Documents/in/Nuclear_medicine?f_ri=39857"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology?f_ri=39857"},{"id":39857,"name":"Molecular 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})();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10334075" data-work_id="10334075" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10334075/Three_pinhole_collimator_to_improve_axial_spatial_resolution_and_sensitivity_in_pinhole_SPECT">Three-pinhole collimator to improve axial spatial resolution and sensitivity in pinhole SPECT</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose The aim of this study was to improve the uniformity of the axial spatial resolution and sensitivity in pinhole single-photon emission computed tomography (SPECT) and to extend the axial field of view, by using a dedicated... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10334075" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose The aim of this study was to improve the uniformity of the axial spatial resolution and sensitivity in pinhole single-photon emission computed tomography (SPECT) and to extend the axial field of view, by using a dedicated three-pinhole collimator. Methods A rectangular tungsten plate with three pinhole apertures of 1.5 mm diameter was designed to image a cylindrical field of view of 55 mm diameter and 160 mm axial length using a clinical gamma camera. To evaluate the non-uniformity of spatial resolution and noise, a multiple-disk phantom was built. The phantom was filled with Tc-99m, and data were acquired using a circular orbit and reconstructed with a dedicated iterative reconstruction algorithm. The axial spatial resolution together with the noise was measured in each disk. These measurements were compared to a single-pinhole system using an identical acquisition geometry and reconstruction. Results At the central slice, a spatial resolution of 2.7 mm was observed for both the three-pinhole and single-pinhole geometries. At 17.5 mm from the central slice, the axial spatial resolution deteriorated to 10.3 mm when using a single pinhole, while the spatial resolution remained 2.7 mm for the three-pinhole system. In the central slice, 19% noise was observed for both geometries. At 31.5 mm from this central slice, the noise remained 19% for the three-pinhole geometry, while it increased to 32% using a single pinhole. Conclusion The presented three-pinhole collimator improves the uniformity of the axial spatial resolution and sensitivity in pinhole SPECT and consequently extends the axial field of view, a requirement for whole-body small-animal imaging.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10334075" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="952bb42e7bc6ba3664b3a13721a1a4cd" rel="nofollow" data-download="{"attachment_id":47433573,"asset_id":10334075,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47433573/download_file?st=MTczMjk5NjMzOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="25339738" href="https://ugent.academia.edu/ChristianVanhove">Christian Vanhove</a><script data-card-contents-for-user="25339738" type="text/json">{"id":25339738,"first_name":"Christian","last_name":"Vanhove","domain_name":"ugent","page_name":"ChristianVanhove","display_name":"Christian Vanhove","profile_url":"https://ugent.academia.edu/ChristianVanhove?f_ri=39857","photo":"https://0.academia-photos.com/25339738/6902567/7787478/s65_christian.vanhove.jpg"}</script></span></span></li><li class="js-paper-rank-work_10334075 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10334075"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10334075, container: ".js-paper-rank-work_10334075", }); 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$(".js-view-count[data-work-id=10334075]").text(description); $(".js-view-count-work_10334075").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_10334075").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="10334075"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="39857" href="https://www.academia.edu/Documents/in/Molecular_Imaging">Molecular Imaging</a>, <script data-card-contents-for-ri="39857" type="text/json">{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="123287" href="https://www.academia.edu/Documents/in/Three_Dimensional_Imaging">Three Dimensional Imaging</a>, <script data-card-contents-for-ri="123287" type="text/json">{"id":123287,"name":"Three Dimensional Imaging","url":"https://www.academia.edu/Documents/in/Three_Dimensional_Imaging?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="372581" href="https://www.academia.edu/Documents/in/Image_Enhancement">Image Enhancement</a><script data-card-contents-for-ri="372581" type="text/json">{"id":372581,"name":"Image Enhancement","url":"https://www.academia.edu/Documents/in/Image_Enhancement?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=10334075]'), work: {"id":10334075,"title":"Three-pinhole collimator to improve axial spatial resolution and sensitivity in pinhole SPECT","created_at":"2015-01-26T01:45:23.325-08:00","url":"https://www.academia.edu/10334075/Three_pinhole_collimator_to_improve_axial_spatial_resolution_and_sensitivity_in_pinhole_SPECT?f_ri=39857","dom_id":"work_10334075","summary":"Purpose The aim of this study was to improve the uniformity of the axial spatial resolution and sensitivity in pinhole single-photon emission computed tomography (SPECT) and to extend the axial field of view, by using a dedicated three-pinhole collimator. Methods A rectangular tungsten plate with three pinhole apertures of 1.5 mm diameter was designed to image a cylindrical field of view of 55 mm diameter and 160 mm axial length using a clinical gamma camera. To evaluate the non-uniformity of spatial resolution and noise, a multiple-disk phantom was built. The phantom was filled with Tc-99m, and data were acquired using a circular orbit and reconstructed with a dedicated iterative reconstruction algorithm. The axial spatial resolution together with the noise was measured in each disk. These measurements were compared to a single-pinhole system using an identical acquisition geometry and reconstruction. Results At the central slice, a spatial resolution of 2.7 mm was observed for both the three-pinhole and single-pinhole geometries. At 17.5 mm from the central slice, the axial spatial resolution deteriorated to 10.3 mm when using a single pinhole, while the spatial resolution remained 2.7 mm for the three-pinhole system. In the central slice, 19% noise was observed for both geometries. At 31.5 mm from this central slice, the noise remained 19% for the three-pinhole geometry, while it increased to 32% using a single pinhole. Conclusion The presented three-pinhole collimator improves the uniformity of the axial spatial resolution and sensitivity in pinhole SPECT and consequently extends the axial field of view, a requirement for whole-body small-animal imaging.","downloadable_attachments":[{"id":47433573,"asset_id":10334075,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":25339738,"first_name":"Christian","last_name":"Vanhove","domain_name":"ugent","page_name":"ChristianVanhove","display_name":"Christian Vanhove","profile_url":"https://ugent.academia.edu/ChristianVanhove?f_ri=39857","photo":"https://0.academia-photos.com/25339738/6902567/7787478/s65_christian.vanhove.jpg"}],"research_interests":[{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false},{"id":123287,"name":"Three Dimensional 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})();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_42908250" data-work_id="42908250" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/42908250/Imaging_of_angiogenesis_in_cardiology">Imaging of angiogenesis in cardiology</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/42908250" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li 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type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3233" href="https://www.academia.edu/Documents/in/Animal_Studies">Animal Studies</a>, <script data-card-contents-for-ri="3233" type="text/json">{"id":3233,"name":"Animal Studies","url":"https://www.academia.edu/Documents/in/Animal_Studies?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7864" href="https://www.academia.edu/Documents/in/Gene_Therapy">Gene Therapy</a><script data-card-contents-for-ri="7864" type="text/json">{"id":7864,"name":"Gene Therapy","url":"https://www.academia.edu/Documents/in/Gene_Therapy?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=42908250]'), work: {"id":42908250,"title":"Imaging of angiogenesis in 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Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857"},{"id":84243,"name":"Medical Biotechnology","url":"https://www.academia.edu/Documents/in/Medical_Biotechnology?f_ri=39857"},{"id":139532,"name":"Bone Density","url":"https://www.academia.edu/Documents/in/Bone_Density?f_ri=39857"},{"id":407130,"name":"Photons","url":"https://www.academia.edu/Documents/in/Photons?f_ri=39857"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=39857"},{"id":2550937,"name":"Molecular probes","url":"https://www.academia.edu/Documents/in/Molecular_probes?f_ri=39857"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13197794" data-work_id="13197794" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain">In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13197794" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess the effects of aging on the benzodiazepine (BDZ) recognition site of the GABA(A) receptor. To visualize BDZ site availability, [(11)C]-flumazenil microPET acquisitions were conducted in young and old rats. The data were analyzed and region of interest analyses were applied to validate the voxel-wise approach. We observed decreased [(11)C]-flumazenil binding in the aged rat brains in comparison with the young control group. More specifically, clusters of reduced radioligand uptake were detected in the bilateral hippocampus, cerebellum, midbrain, and bilateral frontal and parieto-occipital cortex. Our results support the pertinence of voxel-wise quantification in the analysis of microPET data. Moreover, these findings indicate that the aging process i...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13197794" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0e24a690bd41244f9765c46f6877ff87" rel="nofollow" data-download="{"attachment_id":45599407,"asset_id":13197794,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45599407/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32454711" href="https://uv.academia.edu/VictorVictor">Victor Victor</a><script data-card-contents-for-user="32454711" type="text/json">{"id":32454711,"first_name":"Victor","last_name":"Victor","domain_name":"uv","page_name":"VictorVictor","display_name":"Victor Victor","profile_url":"https://uv.academia.edu/VictorVictor?f_ri=39857","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13197794 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13197794"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13197794, container: ".js-paper-rank-work_13197794", }); });</script></li><li class="js-percentile-work_13197794 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13197794; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13197794"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13197794 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13197794"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13197794; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13197794]").text(description); $(".js-view-count-work_13197794").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13197794").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13197794"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6791" href="https://www.academia.edu/Documents/in/Aging">Aging</a>, <script data-card-contents-for-ri="6791" type="text/json">{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23518" href="https://www.academia.edu/Documents/in/Positron_Emission_Tomography">Positron Emission Tomography</a>, <script data-card-contents-for-ri="23518" type="text/json">{"id":23518,"name":"Positron Emission Tomography","url":"https://www.academia.edu/Documents/in/Positron_Emission_Tomography?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="25804" href="https://www.academia.edu/Documents/in/Neurobiology">Neurobiology</a>, <script data-card-contents-for-ri="25804" type="text/json">{"id":25804,"name":"Neurobiology","url":"https://www.academia.edu/Documents/in/Neurobiology?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="39857" href="https://www.academia.edu/Documents/in/Molecular_Imaging">Molecular Imaging</a><script data-card-contents-for-ri="39857" type="text/json">{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13197794]'), work: {"id":13197794,"title":"In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain","created_at":"2015-06-23T00:50:46.942-07:00","url":"https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain?f_ri=39857","dom_id":"work_13197794","summary":"The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess the effects of aging on the benzodiazepine (BDZ) recognition site of the GABA(A) receptor. To visualize BDZ site availability, [(11)C]-flumazenil microPET acquisitions were conducted in young and old rats. The data were analyzed and region of interest analyses were applied to validate the voxel-wise approach. We observed decreased [(11)C]-flumazenil binding in the aged rat brains in comparison with the young control group. More specifically, clusters of reduced radioligand uptake were detected in the bilateral hippocampus, cerebellum, midbrain, and bilateral frontal and parieto-occipital cortex. Our results support the pertinence of voxel-wise quantification in the analysis of microPET data. Moreover, these findings indicate that the aging process i...","downloadable_attachments":[{"id":45599407,"asset_id":13197794,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32454711,"first_name":"Victor","last_name":"Victor","domain_name":"uv","page_name":"VictorVictor","display_name":"Victor Victor","profile_url":"https://uv.academia.edu/VictorVictor?f_ri=39857","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=39857","nofollow":false},{"id":23518,"name":"Positron Emission Tomography","url":"https://www.academia.edu/Documents/in/Positron_Emission_Tomography?f_ri=39857","nofollow":false},{"id":25804,"name":"Neurobiology","url":"https://www.academia.edu/Documents/in/Neurobiology?f_ri=39857","nofollow":false},{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=39857"},{"id":165467,"name":"Rat Brain","url":"https://www.academia.edu/Documents/in/Rat_Brain?f_ri=39857"},{"id":238205,"name":"Cortical Development","url":"https://www.academia.edu/Documents/in/Cortical_Development?f_ri=39857"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=39857"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=39857"},{"id":745296,"name":"Neurobiology of Aging","url":"https://www.academia.edu/Documents/in/Neurobiology_of_Aging?f_ri=39857"},{"id":1010725,"name":"Protein Binding","url":"https://www.academia.edu/Documents/in/Protein_Binding?f_ri=39857"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=39857"},{"id":1372278,"name":"Region of Interest","url":"https://www.academia.edu/Documents/in/Region_of_Interest?f_ri=39857"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group?f_ri=39857"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_69037263" data-work_id="69037263" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/69037263/Tailoring_the_size_distribution_of_ultrasound_contrast_agents_possible_method_for_improving_sensitivity_in_molecular_imaging">Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Encapsulated microbubble contrast agents incorporating an adhesion ligand in the microbubble shell are used for molecular imaging with ultrasound. Currently available microbubble agents are produced with techniques that result in a large... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_69037263" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Encapsulated microbubble contrast agents incorporating an adhesion ligand in the microbubble shell are used for molecular imaging with ultrasound. Currently available microbubble agents are produced with techniques that result in a large size variance. Detection of these contrast agents depends on properties related to the microbubble diameter such as resonant frequency, and current ultrasound imaging systems have bandwidth limits that reduce their sensitivity to a polydisperse contrast agent population. For ultrasonic molecular imaging, in which only a limited number of targeted contrast agents may be retained at the site of pathology, it is important to optimize the sensitivity of the imaging system to the entire population of contrast agent. This article presents contrast agents with a narrow size distribution that are targeted for molecular imaging applications. The production of a functionalized, lipid-encapsulated, microbubble contrast agent with a monodisperse population is demonstrated, and we evaluate parameters that influence the size distribution and demonstrate initial acoustic testing.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/69037263" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9d38887ae4d90d77831df564ecfd8789" rel="nofollow" data-download="{"attachment_id":79289866,"asset_id":69037263,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79289866/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="212858727" href="https://independent.academia.edu/LongoMarjorie">Marjorie Longo</a><script data-card-contents-for-user="212858727" type="text/json">{"id":212858727,"first_name":"Marjorie","last_name":"Longo","domain_name":"independent","page_name":"LongoMarjorie","display_name":"Marjorie Longo","profile_url":"https://independent.academia.edu/LongoMarjorie?f_ri=39857","photo":"https://0.academia-photos.com/212858727/71877142/60330821/s65_marjorie.longo.png"}</script></span></span></li><li class="js-paper-rank-work_69037263 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="69037263"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 69037263, container: ".js-paper-rank-work_69037263", }); });</script></li><li class="js-percentile-work_69037263 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69037263; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_69037263"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_69037263 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="69037263"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69037263; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69037263]").text(description); $(".js-view-count-work_69037263").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_69037263").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="69037263"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">14</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="39857" href="https://www.academia.edu/Documents/in/Molecular_Imaging">Molecular Imaging</a>, <script data-card-contents-for-ri="39857" type="text/json">{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="50157" href="https://www.academia.edu/Documents/in/Molecular">Molecular</a>, <script data-card-contents-for-ri="50157" type="text/json">{"id":50157,"name":"Molecular","url":"https://www.academia.edu/Documents/in/Molecular?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="69542" href="https://www.academia.edu/Documents/in/Computer_Simulation">Computer Simulation</a>, <script data-card-contents-for-ri="69542" type="text/json">{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="90702" href="https://www.academia.edu/Documents/in/Ultrasonography">Ultrasonography</a><script data-card-contents-for-ri="90702" type="text/json">{"id":90702,"name":"Ultrasonography","url":"https://www.academia.edu/Documents/in/Ultrasonography?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=69037263]'), work: {"id":69037263,"title":"Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging","created_at":"2022-01-21T10:50:11.972-08:00","url":"https://www.academia.edu/69037263/Tailoring_the_size_distribution_of_ultrasound_contrast_agents_possible_method_for_improving_sensitivity_in_molecular_imaging?f_ri=39857","dom_id":"work_69037263","summary":"Encapsulated microbubble contrast agents incorporating an adhesion ligand in the microbubble shell are used for molecular imaging with ultrasound. Currently available microbubble agents are produced with techniques that result in a large size variance. Detection of these contrast agents depends on properties related to the microbubble diameter such as resonant frequency, and current ultrasound imaging systems have bandwidth limits that reduce their sensitivity to a polydisperse contrast agent population. For ultrasonic molecular imaging, in which only a limited number of targeted contrast agents may be retained at the site of pathology, it is important to optimize the sensitivity of the imaging system to the entire population of contrast agent. This article presents contrast agents with a narrow size distribution that are targeted for molecular imaging applications. The production of a functionalized, lipid-encapsulated, microbubble contrast agent with a monodisperse population is demonstrated, and we evaluate parameters that influence the size distribution and demonstrate initial acoustic testing.","downloadable_attachments":[{"id":79289866,"asset_id":69037263,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":212858727,"first_name":"Marjorie","last_name":"Longo","domain_name":"independent","page_name":"LongoMarjorie","display_name":"Marjorie Longo","profile_url":"https://independent.academia.edu/LongoMarjorie?f_ri=39857","photo":"https://0.academia-photos.com/212858727/71877142/60330821/s65_marjorie.longo.png"}],"research_interests":[{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false},{"id":50157,"name":"Molecular","url":"https://www.academia.edu/Documents/in/Molecular?f_ri=39857","nofollow":false},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation?f_ri=39857","nofollow":false},{"id":90702,"name":"Ultrasonography","url":"https://www.academia.edu/Documents/in/Ultrasonography?f_ri=39857","nofollow":false},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems?f_ri=39857"},{"id":390245,"name":"Particle Size","url":"https://www.academia.edu/Documents/in/Particle_Size?f_ri=39857"},{"id":695018,"name":"Molecular weight","url":"https://www.academia.edu/Documents/in/Molecular_weight?f_ri=39857"},{"id":796031,"name":"Microbubbles","url":"https://www.academia.edu/Documents/in/Microbubbles?f_ri=39857"},{"id":839246,"name":"Molecular Diagnostic Techniques","url":"https://www.academia.edu/Documents/in/Molecular_Diagnostic_Techniques?f_ri=39857"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=39857"},{"id":1135812,"name":"Drug Compounding","url":"https://www.academia.edu/Documents/in/Drug_Compounding?f_ri=39857"},{"id":1135814,"name":"Drug Stability","url":"https://www.academia.edu/Documents/in/Drug_Stability?f_ri=39857"},{"id":1407305,"name":"Contrast Media","url":"https://www.academia.edu/Documents/in/Contrast_Media?f_ri=39857"},{"id":1952679,"name":"Statistical Distributions","url":"https://www.academia.edu/Documents/in/Statistical_Distributions?f_ri=39857"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_57106476" data-work_id="57106476" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/57106476/False_Positive_FDG_PET_Uptake_the_Role_of_PET_CT">False-Positive FDG PET Uptake−the Role of PET/CT</a></div></div><div class="u-pb4x 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href="https://www.academia.edu/13865231/A_novel_method_of_18F_radiolabeling_for_PET">A novel method of 18F radiolabeling for PET</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Small biomolecules are typically radiolabeled with (18)F by binding it to a carbon atom, a process that usually is designed uniquely for each new molecule and requires several steps and hours to produce. We report a facile method wherein... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13865231" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Small biomolecules are typically radiolabeled with (18)F by binding it to a carbon atom, a process that usually is designed uniquely for each new molecule and requires several steps and hours to produce. We report a facile method wherein (18)F is first attached to aluminum as Al(18)F, which is then bound to a chelate attached to a peptide, forming a</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13865231" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1c8941ad7b7eb0bffbde89b8fc0b4b19" rel="nofollow" data-download="{"attachment_id":38147515,"asset_id":13865231,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/38147515/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32952411" href="https://independent.academia.edu/PeterLaverman">Peter Laverman</a><script data-card-contents-for-user="32952411" type="text/json">{"id":32952411,"first_name":"Peter","last_name":"Laverman","domain_name":"independent","page_name":"PeterLaverman","display_name":"Peter Laverman","profile_url":"https://independent.academia.edu/PeterLaverman?f_ri=39857","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13865231 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13865231"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13865231, container: ".js-paper-rank-work_13865231", }); 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href="https://www.academia.edu/Documents/in/Nuclear_medicine">Nuclear medicine</a>, <script data-card-contents-for-ri="10035" type="text/json">{"id":10035,"name":"Nuclear medicine","url":"https://www.academia.edu/Documents/in/Nuclear_medicine?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="13841" href="https://www.academia.edu/Documents/in/Drug_development">Drug development</a>, <script data-card-contents-for-ri="13841" type="text/json">{"id":13841,"name":"Drug development","url":"https://www.academia.edu/Documents/in/Drug_development?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23518" href="https://www.academia.edu/Documents/in/Positron_Emission_Tomography">Positron Emission Tomography</a>, <script data-card-contents-for-ri="23518" type="text/json">{"id":23518,"name":"Positron Emission 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Developing a molecular imaging agent from bench to the bedside is more... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13754358" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In the past 10 years, significant progress has been made in using a technetium-99m dopamine transporter imaging agent, [99mTc]TRODAT, for routine clinical studies. Developing a molecular imaging agent from bench to the bedside is more than a simple scientific venture. Currently, Taiwan is the only place where [99mTc]TRODAT is approved for routine clinical use in the diagnosis of Parkinson&#39;s disease.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13754358" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="54f3e5794ad6d5d9cca7d76f7fee2008" rel="nofollow" data-download="{"attachment_id":44991219,"asset_id":13754358,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44991219/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32872099" href="https://cgmh.academia.edu/KunjuLin">Kun-ju Lin</a><script data-card-contents-for-user="32872099" type="text/json">{"id":32872099,"first_name":"Kun-ju","last_name":"Lin","domain_name":"cgmh","page_name":"KunjuLin","display_name":"Kun-ju Lin","profile_url":"https://cgmh.academia.edu/KunjuLin?f_ri=39857","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13754358 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13754358"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13754358, container: ".js-paper-rank-work_13754358", }); 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itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/29290554/Optical_image_guided_surgery_where_do_we_stand">Optical image-guided surgery—where do we stand?</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29290554" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="91b24732f93acaba1207a2d22c425be6" rel="nofollow" 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Dedicated coils improve the signal to noise ratio, allowing for faster or higher resolution examinations.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14086740" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dedicated and specialized radiofrequency coils are critical for high quality musculoskeletal magnetic resonance imaging (MRI). Dedicated coils improve the signal to noise ratio, allowing for faster or higher resolution examinations. Transmit-receive coils can reduce heating at high field strength. Finally, novel radiofrequency coils can be used for assessment of tissue biochemistry, as seen with sodium MRI.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14086740" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4be78d9e97ad1ec3fabd9d5772501177" rel="nofollow" data-download="{"attachment_id":44619110,"asset_id":14086740,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44619110/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33097646" href="https://stanford.academia.edu/RonaldWatkins">Ronald Watkins</a><script data-card-contents-for-user="33097646" type="text/json">{"id":33097646,"first_name":"Ronald","last_name":"Watkins","domain_name":"stanford","page_name":"RonaldWatkins","display_name":"Ronald Watkins","profile_url":"https://stanford.academia.edu/RonaldWatkins?f_ri=39857","photo":"https://0.academia-photos.com/33097646/10649029/20743535/s65_ronald.watkins.jpg"}</script></span></span></li><li class="js-paper-rank-work_14086740 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14086740"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14086740, container: ".js-paper-rank-work_14086740", }); 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href="https://www.academia.edu/54980683/The_X_Space_Formulation_of_the_Magnetic_Particle_Imaging_Process_1_D_Signal_Resolution_Bandwidth_SNR_SAR_and_Magnetostimulation">The X-Space Formulation of the Magnetic Particle Imaging Process: 1-D Signal, Resolution, Bandwidth, SNR, SAR, and Magnetostimulation</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/54980683" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c819f5845697970e7f5c1e059f9430a3" rel="nofollow" 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type="text/json">{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1185" href="https://www.academia.edu/Documents/in/Image_Processing">Image Processing</a>, <script data-card-contents-for-ri="1185" type="text/json">{"id":1185,"name":"Image Processing","url":"https://www.academia.edu/Documents/in/Image_Processing?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6200" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a><script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=54980683]'), work: 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_20784206 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="20784206"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20784206; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20784206]").text(description); $(".js-view-count-work_20784206").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20784206").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20784206"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">4</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="37745" href="https://www.academia.edu/Documents/in/Systems_Integration">Systems Integration</a>, <script data-card-contents-for-ri="37745" type="text/json">{"id":37745,"name":"Systems Integration","url":"https://www.academia.edu/Documents/in/Systems_Integration?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37871" href="https://www.academia.edu/Documents/in/Integrative_Biology">Integrative Biology</a>, <script data-card-contents-for-ri="37871" type="text/json">{"id":37871,"name":"Integrative Biology","url":"https://www.academia.edu/Documents/in/Integrative_Biology?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="39857" href="https://www.academia.edu/Documents/in/Molecular_Imaging">Molecular Imaging</a>, <script data-card-contents-for-ri="39857" type="text/json">{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="469018" href="https://www.academia.edu/Documents/in/Neoplasms">Neoplasms</a><script data-card-contents-for-ri="469018" type="text/json">{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20784206]'), work: {"id":20784206,"title":"The challenges of integrating molecular imaging into the optimization of cancer therapy","created_at":"2016-01-25T08:07:31.642-08:00","url":"https://www.academia.edu/20784206/The_challenges_of_integrating_molecular_imaging_into_the_optimization_of_cancer_therapy?f_ri=39857","dom_id":"work_20784206","summary":null,"downloadable_attachments":[{"id":41560202,"asset_id":20784206,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42069287,"first_name":"G.","last_name":"Fruhwirth","domain_name":"kcl","page_name":"GFruhwirth","display_name":"G. 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Administration of phenylhydrazine mainly causes haematotoxicity which leads to the haemolytic anemia. In mammals PHZ induced anemia increased... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6700801" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Phenylhydrazine (PHZ), a potent chemical causes toxicity on various tissues at various levels. Administration of phenylhydrazine mainly causes haematotoxicity which leads to the haemolytic anemia. In mammals PHZ induced anemia increased the iron absorption in spleen, liver and duodenum and finally iron metabolism was altered. Local demand and supply of Fe would increase erythropoeitic activity of the spleen so the size of spleen was increased that create the splenomegaly. PHZ induced anemia activate immune response which triggers phagocytosis in the spleen and liver. Apart from this administration of PHZ interfere the binding of erythropoietin (EPO) with erythropoietin receptors (EPOR) so that JAK-STAT would be affected.PHZ also showed genotoxic effect by creating single strand DNA damage.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6700801" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c2cb8e83530ac9f2517a22ad18842c8d" rel="nofollow" data-download="{"attachment_id":33423749,"asset_id":6700801,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/33423749/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="6882299" href="https://independent.academia.edu/ajpctorg">Am Jour of Phytomed & Clinical Therapeut</a><script data-card-contents-for-user="6882299" type="text/json">{"id":6882299,"first_name":"Am Jour of Phytomed","last_name":"\u0026 Clinical Therapeut","domain_name":"independent","page_name":"ajpctorg","display_name":"Am Jour of Phytomed \u0026 Clinical Therapeut","profile_url":"https://independent.academia.edu/ajpctorg?f_ri=39857","photo":"https://0.academia-photos.com/6882299/2735031/6716662/s65_am_jour_of_phytomed._clinical_therapeut.jpg"}</script></span></span></li><li class="js-paper-rank-work_6700801 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="6700801"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 6700801, container: ".js-paper-rank-work_6700801", }); 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Administration of phenylhydrazine mainly causes haematotoxicity which leads to the haemolytic anemia. In mammals PHZ induced anemia increased the iron absorption in spleen, liver and duodenum and finally iron metabolism was altered. Local demand and supply of Fe would increase erythropoeitic activity of the spleen so the size of spleen was increased that create the splenomegaly. PHZ induced anemia activate immune response which triggers phagocytosis in the spleen and liver. 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data-has-card-for-ri="36213" href="https://www.academia.edu/Documents/in/Energy_Metabolism">Energy Metabolism</a><script data-card-contents-for-ri="36213" type="text/json">{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13117665]'), work: {"id":13117665,"title":"PET Imaging of Breast Cancer Molecular Biomarkers","created_at":"2015-06-20T00:13:18.177-07:00","url":"https://www.academia.edu/13117665/PET_Imaging_of_Breast_Cancer_Molecular_Biomarkers?f_ri=39857","dom_id":"work_13117665","summary":null,"downloadable_attachments":[{"id":45653956,"asset_id":13117665,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32370663,"first_name":"Luca","last_name":"Tagliabue","domain_name":"independent","page_name":"TagliabueLuca","display_name":"Luca 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Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=39857"},{"id":96379,"name":"PET imaging","url":"https://www.academia.edu/Documents/in/PET_imaging?f_ri=39857"},{"id":426588,"name":"Blood Flow","url":"https://www.academia.edu/Documents/in/Blood_Flow?f_ri=39857"},{"id":984451,"name":"Treatment Response","url":"https://www.academia.edu/Documents/in/Treatment_Response?f_ri=39857"},{"id":1178162,"name":"Tumor Growth","url":"https://www.academia.edu/Documents/in/Tumor_Growth?f_ri=39857"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18333540" data-work_id="18333540" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18333540/Nanomedicine_Tiny_Particles_and_Machines_Give_Huge_Gains">Nanomedicine: Tiny Particles and Machines Give Huge Gains</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Nano-scale structures and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18333540" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Nano-scale structures and devices are compatible in size with proteins and nucleic acids in living cells. Therefore, the design, characterization and application of nano-scale probes, carriers and machines may provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection, therapy, and prevention. Recent advances in nanomedicine include the development of nanoparticle (NP)-based probes for molecular imaging, nano-carriers for drug/gene delivery, multifunctional NPs for theranostics, and molecular machines for biological and medical studies. This article provides an overview of the nanomedicine field, with an emphasis on NPs for imaging and therapy, as well as engineered nucleases for genome editing. The challenges in translating nanomedicine approaches to clinical applications are discussed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18333540" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="43a96dbb7974c75461380fd016ec177c" rel="nofollow" data-download="{"attachment_id":42177124,"asset_id":18333540,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42177124/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38228612" href="https://independent.academia.edu/ThomasCradick">Thomas Cradick</a><script data-card-contents-for-user="38228612" type="text/json">{"id":38228612,"first_name":"Thomas","last_name":"Cradick","domain_name":"independent","page_name":"ThomasCradick","display_name":"Thomas Cradick","profile_url":"https://independent.academia.edu/ThomasCradick?f_ri=39857","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18333540 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18333540"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18333540, container: ".js-paper-rank-work_18333540", }); 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$(".js-view-count[data-work-id=18333540]").text(description); $(".js-view-count-work_18333540").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18333540").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18333540"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">5</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="48" href="https://www.academia.edu/Documents/in/Engineering">Engineering</a>, <script data-card-contents-for-ri="48" type="text/json">{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="68" href="https://www.academia.edu/Documents/in/Bioengineering">Bioengineering</a>, <script data-card-contents-for-ri="68" type="text/json">{"id":68,"name":"Bioengineering","url":"https://www.academia.edu/Documents/in/Bioengineering?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="11972" href="https://www.academia.edu/Documents/in/Nanomedicine">Nanomedicine</a>, <script data-card-contents-for-ri="11972" type="text/json">{"id":11972,"name":"Nanomedicine","url":"https://www.academia.edu/Documents/in/Nanomedicine?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="13621" href="https://www.academia.edu/Documents/in/Nanoparticles">Nanoparticles</a><script data-card-contents-for-ri="13621" type="text/json">{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18333540]'), work: {"id":18333540,"title":"Nanomedicine: Tiny Particles and Machines Give Huge Gains","created_at":"2015-11-14T09:08:41.975-08:00","url":"https://www.academia.edu/18333540/Nanomedicine_Tiny_Particles_and_Machines_Give_Huge_Gains?f_ri=39857","dom_id":"work_18333540","summary":"Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Nano-scale structures and devices are compatible in size with proteins and nucleic acids in living cells. Therefore, the design, characterization and application of nano-scale probes, carriers and machines may provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection, therapy, and prevention. Recent advances in nanomedicine include the development of nanoparticle (NP)-based probes for molecular imaging, nano-carriers for drug/gene delivery, multifunctional NPs for theranostics, and molecular machines for biological and medical studies. This article provides an overview of the nanomedicine field, with an emphasis on NPs for imaging and therapy, as well as engineered nucleases for genome editing. The challenges in translating nanomedicine approaches to clinical applications are discussed.","downloadable_attachments":[{"id":42177124,"asset_id":18333540,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38228612,"first_name":"Thomas","last_name":"Cradick","domain_name":"independent","page_name":"ThomasCradick","display_name":"Thomas Cradick","profile_url":"https://independent.academia.edu/ThomasCradick?f_ri=39857","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=39857","nofollow":false},{"id":68,"name":"Bioengineering","url":"https://www.academia.edu/Documents/in/Bioengineering?f_ri=39857","nofollow":false},{"id":11972,"name":"Nanomedicine","url":"https://www.academia.edu/Documents/in/Nanomedicine?f_ri=39857","nofollow":false},{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles?f_ri=39857","nofollow":false},{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15649421" data-work_id="15649421" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15649421/CYCLOTRON_PRODUCTION_OF_HIGH_SPECIFIC_ACTIVITY_RADIOCHEMICAL_FORMS_OF_VANADIUM_MANGANESE_AND_THALLIUM_FOR_METALLO_TOXICOLOGICAL_STUDIES">CYCLOTRON PRODUCTION OF "HIGH SPECIFIC ACTIVITY" RADIOCHEMICAL FORMS OF VANADIUM, MANGANESE AND THALLIUM FOR METALLO-TOXICOLOGICAL STUDIES</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In this paper are presented the production methods for very &quot;high specific activity&quot; radionuclides (HSARNs) of vanadium (V), manganese (Mn) and thallium (Tl), which have been developed in our laboratories for labeling different... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15649421" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In this paper are presented the production methods for very &quot;high specific activity&quot; radionuclides (HSARNs) of vanadium (V), manganese (Mn) and thallium (Tl), which have been developed in our laboratories for labeling different chemical forms of these elements present in the echo-systems in ultra-trace amounts, for metallo-toxicological and bio-kinetic studies. Use was made of both cyclotron and thermal nuclear reactor. If the nuclear reaction and/or decay product has atomic number different from irradiated target, it is possible separating the radioactive nuclide from irradiated target, without intentional addition of isotopic carrier. These kinds of radionuclides are named No Carrier Added, NCA, and their specific activity is very high and can reach values close to the theoretical Carrier Free one, CF. The experimental determination of specific activity, chemical and radiochemical purities is mandatory for all these kinds of applications.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15649421" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e9650a4d839dda592e2335bc647ae505" rel="nofollow" data-download="{"attachment_id":41198687,"asset_id":15649421,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41198687/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34833678" href="https://unimi.academia.edu/FlaviaGroppi">Flavia Groppi</a><script data-card-contents-for-user="34833678" type="text/json">{"id":34833678,"first_name":"Flavia","last_name":"Groppi","domain_name":"unimi","page_name":"FlaviaGroppi","display_name":"Flavia Groppi","profile_url":"https://unimi.academia.edu/FlaviaGroppi?f_ri=39857","photo":"https://0.academia-photos.com/34833678/10153840/11330480/s65_flavia.groppi.jpg"}</script></span></span></li><li class="js-paper-rank-work_15649421 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15649421"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15649421, container: ".js-paper-rank-work_15649421", }); });</script></li><li class="js-percentile-work_15649421 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15649421; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_15649421"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_15649421 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="15649421"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15649421; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15649421]").text(description); $(".js-view-count-work_15649421").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_15649421").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="15649421"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">5</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="4987" href="https://www.academia.edu/Documents/in/Kinetics">Kinetics</a>, <script data-card-contents-for-ri="4987" type="text/json">{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="39857" href="https://www.academia.edu/Documents/in/Molecular_Imaging">Molecular Imaging</a>, <script data-card-contents-for-ri="39857" type="text/json">{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="191590" href="https://www.academia.edu/Documents/in/Nuclear_reactor">Nuclear reactor</a>, <script data-card-contents-for-ri="191590" type="text/json">{"id":191590,"name":"Nuclear reactor","url":"https://www.academia.edu/Documents/in/Nuclear_reactor?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="230832" href="https://www.academia.edu/Documents/in/Nuclear_Reactions">Nuclear Reactions</a><script data-card-contents-for-ri="230832" type="text/json">{"id":230832,"name":"Nuclear Reactions","url":"https://www.academia.edu/Documents/in/Nuclear_Reactions?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15649421]'), work: {"id":15649421,"title":"CYCLOTRON PRODUCTION OF \"HIGH SPECIFIC ACTIVITY\" RADIOCHEMICAL FORMS OF VANADIUM, MANGANESE AND THALLIUM FOR METALLO-TOXICOLOGICAL STUDIES","created_at":"2015-09-13T08:10:00.384-07:00","url":"https://www.academia.edu/15649421/CYCLOTRON_PRODUCTION_OF_HIGH_SPECIFIC_ACTIVITY_RADIOCHEMICAL_FORMS_OF_VANADIUM_MANGANESE_AND_THALLIUM_FOR_METALLO_TOXICOLOGICAL_STUDIES?f_ri=39857","dom_id":"work_15649421","summary":"In this paper are presented the production methods for very \u0026quot;high specific activity\u0026quot; radionuclides (HSARNs) of vanadium (V), manganese (Mn) and thallium (Tl), which have been developed in our laboratories for labeling different chemical forms of these elements present in the echo-systems in ultra-trace amounts, for metallo-toxicological and bio-kinetic studies. Use was made of both cyclotron and thermal nuclear reactor. If the nuclear reaction and/or decay product has atomic number different from irradiated target, it is possible separating the radioactive nuclide from irradiated target, without intentional addition of isotopic carrier. These kinds of radionuclides are named No Carrier Added, NCA, and their specific activity is very high and can reach values close to the theoretical Carrier Free one, CF. The experimental determination of specific activity, chemical and radiochemical purities is mandatory for all these kinds of applications.","downloadable_attachments":[{"id":41198687,"asset_id":15649421,"asset_type":"Work","always_allow_download":false},{"id":41198887,"asset_id":15649421,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34833678,"first_name":"Flavia","last_name":"Groppi","domain_name":"unimi","page_name":"FlaviaGroppi","display_name":"Flavia Groppi","profile_url":"https://unimi.academia.edu/FlaviaGroppi?f_ri=39857","photo":"https://0.academia-photos.com/34833678/10153840/11330480/s65_flavia.groppi.jpg"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=39857","nofollow":false},{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false},{"id":191590,"name":"Nuclear reactor","url":"https://www.academia.edu/Documents/in/Nuclear_reactor?f_ri=39857","nofollow":false},{"id":230832,"name":"Nuclear Reactions","url":"https://www.academia.edu/Documents/in/Nuclear_Reactions?f_ri=39857","nofollow":false},{"id":399886,"name":"Specific Activity","url":"https://www.academia.edu/Documents/in/Specific_Activity?f_ri=39857"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_75870841" data-work_id="75870841" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/75870841/Na_K_ATPase_%CE%B13_is_a_death_target_of_Alzheimer_patient_amyloid_%CE%B2_assembly">Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_75870841" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that cause selective degeneration of mature neurons. Here, we show that the ASPD target is neuron-specific Na+/K+-ATPase α3 subunit (NAKα3). ASPD-binding to NAKα3 impaired NAKα3-specific activity, activated N-type voltage-gated calcium channels, and caused mitochondrial calcium dyshomeostasis, tau abnormalities, and neurodegeneration. NMR and molecular modeling studies suggested that spherical ASPD contain N-terminal-Aβ–derived “thorns” responsible for target binding, which are distinct from low molecular-weight oligomers and dodecamers. The fourth extracellular loop (Ex4) region of NAKα3 encompassing Asn879 and Trp880 is essential for ASPD–NAKα3 interaction, because tetrapeptides mimicking this E...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/75870841" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d97bb2ab4873ff8b7de930dffb41c3c3" rel="nofollow" data-download="{"attachment_id":83521360,"asset_id":75870841,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83521360/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35587636" href="https://u-fukui.academia.edu/YugoFukazawa">Yugo Fukazawa</a><script data-card-contents-for-user="35587636" type="text/json">{"id":35587636,"first_name":"Yugo","last_name":"Fukazawa","domain_name":"u-fukui","page_name":"YugoFukazawa","display_name":"Yugo Fukazawa","profile_url":"https://u-fukui.academia.edu/YugoFukazawa?f_ri=39857","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_75870841 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="75870841"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 75870841, container: ".js-paper-rank-work_75870841", }); });</script></li><li class="js-percentile-work_75870841 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75870841; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_75870841"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_75870841 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="75870841"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75870841; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75870841]").text(description); $(".js-view-count-work_75870841").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_75870841").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="75870841"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">18</a> </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="5769" href="https://www.academia.edu/Documents/in/Mass_Spectrometry">Mass Spectrometry</a>, <script data-card-contents-for-ri="5769" type="text/json">{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9534" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a>, <script data-card-contents-for-ri="9534" type="text/json">{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="28235" href="https://www.academia.edu/Documents/in/Multidisciplinary">Multidisciplinary</a>, <script data-card-contents-for-ri="28235" type="text/json">{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a><script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=75870841]'), work: {"id":75870841,"title":"Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly","created_at":"2022-04-08T21:15:52.546-07:00","url":"https://www.academia.edu/75870841/Na_K_ATPase_%CE%B13_is_a_death_target_of_Alzheimer_patient_amyloid_%CE%B2_assembly?f_ri=39857","dom_id":"work_75870841","summary":"Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that cause selective degeneration of mature neurons. Here, we show that the ASPD target is neuron-specific Na+/K+-ATPase α3 subunit (NAKα3). ASPD-binding to NAKα3 impaired NAKα3-specific activity, activated N-type voltage-gated calcium channels, and caused mitochondrial calcium dyshomeostasis, tau abnormalities, and neurodegeneration. NMR and molecular modeling studies suggested that spherical ASPD contain N-terminal-Aβ–derived “thorns” responsible for target binding, which are distinct from low molecular-weight oligomers and dodecamers. The fourth extracellular loop (Ex4) region of NAKα3 encompassing Asn879 and Trp880 is essential for ASPD–NAKα3 interaction, because tetrapeptides mimicking this E...","downloadable_attachments":[{"id":83521360,"asset_id":75870841,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35587636,"first_name":"Yugo","last_name":"Fukazawa","domain_name":"u-fukui","page_name":"YugoFukazawa","display_name":"Yugo Fukazawa","profile_url":"https://u-fukui.academia.edu/YugoFukazawa?f_ri=39857","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=39857","nofollow":false},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=39857","nofollow":false},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=39857","nofollow":false},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=39857","nofollow":false},{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death?f_ri=39857"},{"id":151086,"name":"Peptides","url":"https://www.academia.edu/Documents/in/Peptides?f_ri=39857"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=39857"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=39857"},{"id":379889,"name":"Homeostasis","url":"https://www.academia.edu/Documents/in/Homeostasis?f_ri=39857"},{"id":386342,"name":"Sodium","url":"https://www.academia.edu/Documents/in/Sodium?f_ri=39857"},{"id":695018,"name":"Molecular weight","url":"https://www.academia.edu/Documents/in/Molecular_weight?f_ri=39857"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=39857"},{"id":1010725,"name":"Protein Binding","url":"https://www.academia.edu/Documents/in/Protein_Binding?f_ri=39857"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease?f_ri=39857"},{"id":2068869,"name":"Academy of Sciences and Letters","url":"https://www.academia.edu/Documents/in/Academy_of_Sciences_and_Letters?f_ri=39857"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data?f_ri=39857"},{"id":3313374,"name":"Protein aggregates","url":"https://www.academia.edu/Documents/in/Protein_aggregates?f_ri=39857"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18821238" data-work_id="18821238" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18821238/Use_of_Organ_Explant_and_Cell_Culture_in_Cancer_Research">Use of Organ Explant and Cell Culture in Cancer Research</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18821238" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="68c433b51cf0139698239592bd05e968" rel="nofollow" data-download="{"attachment_id":40273209,"asset_id":18821238,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40273209/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38908439" href="https://independent.academia.edu/JamesResau">James Resau</a><script data-card-contents-for-user="38908439" 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window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_18821238"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_18821238 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="18821238"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 18821238; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=18821238]").text(description); $(".js-view-count-work_18821238").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18821238").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18821238"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">6</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5795" href="https://www.academia.edu/Documents/in/Multiphoton_Microscopy">Multiphoton Microscopy</a>, <script data-card-contents-for-ri="5795" type="text/json">{"id":5795,"name":"Multiphoton Microscopy","url":"https://www.academia.edu/Documents/in/Multiphoton_Microscopy?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37782" href="https://www.academia.edu/Documents/in/Cell_Culture">Cell Culture</a>, <script data-card-contents-for-ri="37782" type="text/json">{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="39857" href="https://www.academia.edu/Documents/in/Molecular_Imaging">Molecular Imaging</a><script data-card-contents-for-ri="39857" type="text/json">{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18821238]'), work: {"id":18821238,"title":"Use of Organ Explant and Cell Culture in Cancer Research","created_at":"2015-11-22T13:47:45.252-08:00","url":"https://www.academia.edu/18821238/Use_of_Organ_Explant_and_Cell_Culture_in_Cancer_Research?f_ri=39857","dom_id":"work_18821238","summary":null,"downloadable_attachments":[{"id":40273209,"asset_id":18821238,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38908439,"first_name":"James","last_name":"Resau","domain_name":"independent","page_name":"JamesResau","display_name":"James Resau","profile_url":"https://independent.academia.edu/JamesResau?f_ri=39857","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=39857","nofollow":false},{"id":5795,"name":"Multiphoton Microscopy","url":"https://www.academia.edu/Documents/in/Multiphoton_Microscopy?f_ri=39857","nofollow":false},{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture?f_ri=39857","nofollow":false},{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false},{"id":177205,"name":"Mechanisms","url":"https://www.academia.edu/Documents/in/Mechanisms?f_ri=39857"},{"id":216315,"name":"Laser Scanning Confocal Microscopy","url":"https://www.academia.edu/Documents/in/Laser_Scanning_Confocal_Microscopy?f_ri=39857"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21428102" data-work_id="21428102" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21428102/Nanoparticle_Based_Tumor_Theranostics_with_Molecular_Imaging">Nanoparticle-Based Tumor Theranostics with Molecular Imaging</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21428102" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="60328a8a219137fd1f9afe8d1be41685" rel="nofollow" data-download="{"attachment_id":41868229,"asset_id":21428102,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41868229/download_file?st=MTczMjk5NjMzOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42498357" href="https://independent.academia.edu/LiZongjin">Zongjin Li</a><script data-card-contents-for-user="42498357" type="text/json">{"id":42498357,"first_name":"Zongjin","last_name":"Li","domain_name":"independent","page_name":"LiZongjin","display_name":"Zongjin Li","profile_url":"https://independent.academia.edu/LiZongjin?f_ri=39857","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21428102 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21428102"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21428102, container: ".js-paper-rank-work_21428102", }); });</script></li><li class="js-percentile-work_21428102 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21428102; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21428102"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21428102 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21428102"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21428102; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21428102]").text(description); $(".js-view-count-work_21428102").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21428102").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21428102"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i> <a class="InlineList-item-text u-positionRelative">6</a> </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="13621" href="https://www.academia.edu/Documents/in/Nanoparticles">Nanoparticles</a>, <script data-card-contents-for-ri="13621" type="text/json">{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="39857" href="https://www.academia.edu/Documents/in/Molecular_Imaging">Molecular Imaging</a>, <script data-card-contents-for-ri="39857" type="text/json">{"id":39857,"name":"Molecular Imaging","url":"https://www.academia.edu/Documents/in/Molecular_Imaging?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="84243" href="https://www.academia.edu/Documents/in/Medical_Biotechnology">Medical Biotechnology</a>, <script data-card-contents-for-ri="84243" type="text/json">{"id":84243,"name":"Medical Biotechnology","url":"https://www.academia.edu/Documents/in/Medical_Biotechnology?f_ri=39857","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="159187" href="https://www.academia.edu/Documents/in/Drug_Delivery_Systems">Drug Delivery Systems</a><script data-card-contents-for-ri="159187" type="text/json">{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems?f_ri=39857","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21428102]'), work: {"id":21428102,"title":"Nanoparticle-Based Tumor Theranostics with Molecular 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