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id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Obsah</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">presunúť do postranného panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">skryť</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Začiatok</div> </a> </li> <li id="toc-Biosyntetická_dráha" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Biosyntetická_dráha"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Biosyntetická dráha</span> </div> </a> <ul id="toc-Biosyntetická_dráha-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Úloha_hypermodifikácií_v_stabilizácii_RNA" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Úloha_hypermodifikácií_v_stabilizácii_RNA"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Úloha hypermodifikácií v stabilizácii RNA</span> </div> </a> <ul id="toc-Úloha_hypermodifikácií_v_stabilizácii_RNA-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Potenciál_pre_posun_čítacieho_rámca" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Potenciál_pre_posun_čítacieho_rámca"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Potenciál pre posun čítacieho rámca</span> </div> </a> <ul id="toc-Potenciál_pre_posun_čítacieho_rámca-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Referencie" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Referencie"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Referencie</span> </div> </a> <ul id="toc-Referencie-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Zdroj" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Zdroj"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Zdroj</span> </div> </a> <ul id="toc-Zdroj-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Obsah" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Prepnúť obsah" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Prepnúť obsah</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Wybutozín</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Prejsť na článok v inom jazyku. Je dostupný v 6 jazykoch" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-6" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">6 jazykov</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%88%D8%A7%D9%8A%D8%A8%D9%88%D8%AA%D9%88%D8%B3%D9%8A%D9%86" title="وايبوتوسين – arabčina" lang="ar" hreflang="ar" data-title="وايبوتوسين" data-language-autonym="العربية" data-language-local-name="arabčina" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Wybutosin" title="Wybutosin – nemčina" lang="de" hreflang="de" data-title="Wybutosin" data-language-autonym="Deutsch" data-language-local-name="nemčina" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Wybutosine" title="Wybutosine – angličtina" lang="en" hreflang="en" data-title="Wybutosine" data-language-autonym="English" data-language-local-name="angličtina" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Wybutosine" title="Wybutosine – francúzština" lang="fr" hreflang="fr" data-title="Wybutosine" data-language-autonym="Français" data-language-local-name="francúzština" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%9C%84%EB%B6%80%ED%86%A0%EC%8B%A0" title="위부토신 – kórejčina" lang="ko" hreflang="ko" data-title="위부토신" data-language-autonym="한국어" data-language-local-name="kórejčina" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Wibutosina" title="Wibutosina – malajčina" lang="ms" hreflang="ms" data-title="Wibutosina" data-language-autonym="Bahasa Melayu" data-language-local-name="malajčina" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q1310878#sitelinks-wikipedia" title="Upraviť medzijazykové odkazy" class="wbc-editpage">Upraviť odkazy</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Menné priestory"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Wybutoz%C3%ADn" title="Zobraziť obsah stránky [c]" accesskey="c"><span>Stránka</span></a></li><li id="ca-talk" class="new vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Diskusia:Wybutoz%C3%ADn&action=edit&redlink=1" rel="discussion" class="new" title="Diskusia o obsahu stránky (stránka neexistuje) [t]" accesskey="t"><span>Diskusia</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Změnit variantu jazyka" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">slovenčina</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Zobrazenia"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Wybutoz%C3%ADn"><span>Čítať</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&veaction=edit" title="Upraviť túto stránku [v]" accesskey="v"><span>Upraviť</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&action=edit" title="Upraviť zdrojový kód tejto stránky [e]" accesskey="e"><span>Upraviť zdroj</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&action=history" title="Minulé revízie tejto stránky. [h]" accesskey="h"><span>Zobraziť históriu</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Nástroje stránky"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Nástroje" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Nástroje</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Nástroje</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">presunúť do postranného panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">skryť</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Další možnosti" > <div class="vector-menu-heading"> Akcie </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Wybutoz%C3%ADn"><span>Čítať</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&veaction=edit" title="Upraviť túto stránku [v]" accesskey="v"><span>Upraviť</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&action=edit" title="Upraviť zdrojový kód tejto stránky [e]" accesskey="e"><span>Upraviť zdroj</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&action=history"><span>Zobraziť históriu</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Všeobecné </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/%C5%A0peci%C3%A1lne:%C4%8CoOdkazujeSem/Wybutoz%C3%ADn" title="Zoznam všetkých wiki stránok, ktoré sem odkazujú [j]" accesskey="j"><span>Odkazy na túto stránku</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/%C5%A0peci%C3%A1lne:S%C3%BAvisiacePosledn%C3%A9%C3%9Apravy/Wybutoz%C3%ADn" rel="nofollow" title="Posledné úpravy na stránkach, na ktoré odkazuje táto stránka [k]" accesskey="k"><span>Súvisiace úpravy</span></a></li><li id="t-upload" class="mw-list-item"><a href="//commons.wikimedia.org/wiki/Special:UploadWizard?uselang=sk" title="Nahranie súborov [u]" accesskey="u"><span>Nahrať súbor</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/%C5%A0peci%C3%A1lne:%C5%A0peci%C3%A1lneStr%C3%A1nky" title="Zoznam všetkých špeciálnych stránok [q]" accesskey="q"><span>Špeciálne stránky</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&oldid=7318445" title="Trvalý odkaz na túto verziu stránky"><span>Trvalý odkaz</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&action=info" title="Viac informácií o tejto stránke"><span>Informácie o stránke</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=%C5%A0peci%C3%A1lne:Citova%C5%A5&page=Wybutoz%C3%ADn&id=7318445&wpFormIdentifier=titleform" title="Informácie ako citovať túto stránku"><span>Citovať túto stránku</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=%C5%A0peci%C3%A1lne:UrlQ%C4%B1sald%C4%B1c%C4%B1s%C4%B1&url=https%3A%2F%2Fsk.wikipedia.org%2Fwiki%2FWybutoz%25C3%25ADn"><span>Získať skrátené URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=%C5%A0peci%C3%A1lne:QrKodu&url=https%3A%2F%2Fsk.wikipedia.org%2Fwiki%2FWybutoz%25C3%25ADn"><span>Stiahnuť QR kód</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Tlačiť/exportovať </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=%C5%A0peci%C3%A1lne:Knihy&bookcmd=book_creator&referer=Wybutoz%C3%ADn"><span>Vytvoriť knihu</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=%C5%A0peci%C3%A1lne:DownloadAsPdf&page=Wybutoz%C3%ADn&action=show-download-screen"><span>Stiahnuť ako PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Wybutoz%C3%ADn&printable=yes" title="Verzia tejto stránky pre tlač [p]" accesskey="p"><span>Verzia pre tlač</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> V iných projektoch </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q1310878" title="Odkaz na prepojenú položku dátového úložiska [g]" accesskey="g"><span>Položka Wikidata</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Nástroje stránky"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Vzhľad"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Vzhľad</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">presunúť do postranného panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">skryť</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">z Wikipédie, slobodnej encyklopédie</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sk" dir="ltr"><table class="infobox bordered" cellpadding="2" style="width: 300px; font-size:89%"> <tbody><tr> <td colspan="2" style="background-color: #F8EABA; text-align:center; font-weight:bold; font-size:120%">Wybutozín </td></tr> <tr> <td align="center" colspan="2" style="background:white"><figure class="mw-halign-center" typeof="mw:File"><a href="/wiki/S%C3%BAbor:Wybutosine.svg" class="mw-file-description" title="Wybutozín"><img alt="Wybutozín" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cf/Wybutosine.svg/180px-Wybutosine.svg.png" decoding="async" width="180" height="156" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cf/Wybutosine.svg/270px-Wybutosine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cf/Wybutosine.svg/360px-Wybutosine.svg.png 2x" data-file-width="620" data-file-height="537" /></a><figcaption>Wybutozín</figcaption></figure> </td></tr> <tr> <td colspan="2" style="background-color: #F8EABA; text-align:center;"><b>Všeobecné vlastnosti</b> </td></tr> <tr> <td style="background: #eeeeee; vertical-align: top;"><a href="/wiki/Sum%C3%A1rny_vzorec" title="Sumárny vzorec">Sumárny vzorec</a> </td> <td>C<sub>21</sub>H<sub>28</sub>N<sub>6</sub>O<sub>9</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> </td></tr> <tr> <td colspan="2" style="background-color: #F8EABA; text-align:center;"><b>Fyzikálne vlastnosti</b> </td></tr> <tr> <td style="background: #eeeeee; vertical-align: top;"><a href="/wiki/Mol%C3%A1rna_hmotnos%C5%A5" title="Molárna hmotnosť">Molárna hmotnosť</a> </td> <td>508,488 g/mol </td></tr> <tr> <td colspan="2" style="background-color: #F8EABA; text-align:center;"><b>Ďalšie informácie</b> </td></tr> <tr> <td style="background: #eeeeee; vertical-align: top;"><a href="/wiki/Registra%C4%8Dn%C3%A9_%C4%8D%C3%ADslo_CAS" title="Registračné číslo CAS">Číslo CAS</a> </td> <td>55196-46-8 </td></tr> <tr> <td colspan="2" style="background-color: #F8EABA; font-size:90%; text-align:center">Pokiaľ je to možné a bežné, používame jednotky sústavy <a href="/wiki/SI" title="SI">SI</a>. <br /> Ak nie je hore uvedené inak, údaje sú za <a href="/wiki/Norm%C3%A1lne_podmienky" title="Normálne podmienky">normálnych podmienok</a>. </td></tr> <tr> <td colspan="2" title="Portál, ktorého súčasťou je táto stránka" style="text-align:center; border-top: 1px solid #aaa;"><div style="border: solid #aaa 1px; background: #f9f9f9; padding: 0ex 1ex; display:inline-table; padding: 0ex 0.05ex; border-style:none; background:transparent;" title="Portál, ktorého súčasťou je táto stránka"> <table style="margin: 0; padding: 0ex"> <tbody><tr> <td style="vertical-align:middle;margin: 0;border:none;"> </td> <td style="text-align:left;border:none;"><span class="noviewer" typeof="mw:File"><a href="/wiki/Port%C3%A1l:Ch%C3%A9mia" title="Chemický portál"><img alt="Chemický portál" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/Chemistrylogo.png/18px-Chemistrylogo.png" decoding="async" width="18" height="18" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/Chemistrylogo.png/27px-Chemistrylogo.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/24/Chemistrylogo.png/36px-Chemistrylogo.png 2x" data-file-width="40" data-file-height="40" /></a></span> <a href="/wiki/Port%C3%A1l:Ch%C3%A9mia" title="Portál:Chémia">Chemický portál</a> </td></tr></tbody></table></div> </td></tr></tbody></table> <p><b>Wybutozín</b><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> (<b>yW</b>) je modifikovaný <a href="/wiki/Nukleozid" title="Nukleozid">nukleozid</a>, ktorý sa nachádza v <a href="/wiki/Transferov%C3%A1_ribonukleov%C3%A1_kyselina" title="Transferová ribonukleová kyselina">transferovej RNA</a> <a href="/wiki/Fenylalan%C3%ADn" title="Fenylalanín">fenylalanínu</a> a stabilizuje interakciu medzi <a href="/wiki/Kod%C3%B3n" title="Kodón">kodónom</a> a <a href="/wiki/Antikod%C3%B3n" title="Antikodón">antikodónom</a> počas <a href="/wiki/Proteosynt%C3%A9za" title="Proteosyntéza">proteosyntézy</a>.<sup id="cite_ref-Noma_2-0" class="reference"><a href="#cite_note-Noma-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Presný priebeh syntézy bielkovín je esenciálny pre zdravie bunky, inak môžu poruchy modifikácií tRNA spôsobiť choroby. U <a href="/wiki/Eukaryot" class="mw-redirect" title="Eukaryot">eukaryotických</a> organizmov sa wybutozín nachádza len na pozícii 37, teda na 3' strane antikodónu, v tRNA fenylalanínu. Wybutozín zaručuje správnu <a href="/wiki/Transl%C3%A1cia_(genetika)" title="Translácia (genetika)">transláciu</a> vďaka stabilizácii <a href="/wiki/B%C3%A1zov%C3%BD_p%C3%A1r" title="Bázový pár">párovania báz</a> pri kodón-antikodónovej interakcii.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Biosyntetická_dráha"><span id="Biosyntetick.C3.A1_dr.C3.A1ha"></span>Biosyntetická dráha</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Wybutoz%C3%ADn&veaction=edit&section=1" title="Upraviť sekciu: Biosyntetická dráha" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Wybutoz%C3%ADn&action=edit&section=1" title="Editovat zdrojový kód sekce Biosyntetická dráha"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/w/index.php?title=Biosynt%C3%A9za&action=edit&redlink=1" class="new" title="Biosyntéza (stránka neexistuje)">Biosyntetická</a> dráha wybutozínu bola navrhnutá s použitím modelu <i><a href="/wiki/Saccharomyces_cerevisiae" class="mw-redirect" title="Saccharomyces cerevisiae">S. cerevisiae</a></i>. Prvý krok syntézy katalyzuje N1-metyltransferáza TRM5, ktorá <a href="/w/index.php?title=Metyl%C3%A1cia&action=edit&redlink=1" class="new" title="Metylácia (stránka neexistuje)">metyluje</a> G37 tRNA fenylalanínu a mení ho na m1G37. Následne je m1G37 substrátom pre enzým TYW1, ktorý pomocou <a href="/wiki/Pyruv%C3%A1t" class="mw-redirect" title="Pyruvát">pyruvátu</a> vytvorí tricyklické jadro wybutozínu. <a href="/wiki/Kofaktor_(bioch%C3%A9mia)" title="Kofaktor (biochémia)">Kofaktorom</a> tejto reakcie je <a href="/wiki/Flav%C3%ADnmononukleotid" title="Flavínmononukleotid">FMN</a>. Enzým TYW2 potom prenáša α-amino-α-karboxypropylovú skupinu zo <a href="/wiki/S-adenozylmetion%C3%ADn" title="S-adenozylmetionín">SAM</a>, ktorý sa bežne používa ako kofaktor pri prenosoch metylovej skupiny, na bočnú C7 pozíciu yW-187, čím vzniká yW-86. Enzým TYW3 potom katalyzuje N-4 metyláciu yW-86, čím vzniká yW-72. TYW4 a SAM-dependentná karboxymetyltransferáza potom metylujú α-karboxylovú skupinu yW-72 za vzniku yW-57. Posledným krokom, ktorý katalyzuje druhá aktivita TYW4, je metoxykarbonylácia α-amino skupiny bočného reťazca yW-58, čím vzniká wybutozín.<sup id="cite_ref-:0_5-0" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-halign-center" typeof="mw:File/Thumb"><a href="/wiki/S%C3%BAbor:Wybutosine.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Wybutosine.png/300px-Wybutosine.png" decoding="async" width="300" height="260" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Wybutosine.png/450px-Wybutosine.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Wybutosine.png/600px-Wybutosine.png 2x" data-file-width="620" data-file-height="537" /></a><figcaption>Wybutozín a enzýmy, ktoré sa účastnia jeho biosyntézy. Enzým a skupina, ktorú pripája, sú označené farebne.<sup id="cite_ref-:0_5-1" class="reference"><a href="#cite_note-:0-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p>Wybutozín sa podarilo syntetizovať i chemicky.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Úloha_hypermodifikácií_v_stabilizácii_RNA"><span id=".C3.9Aloha_hypermodifik.C3.A1ci.C3.AD_v_stabiliz.C3.A1cii_RNA"></span>Úloha hypermodifikácií v stabilizácii RNA</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Wybutoz%C3%ADn&veaction=edit&section=2" title="Upraviť sekciu: Úloha hypermodifikácií v stabilizácii RNA" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Wybutoz%C3%ADn&action=edit&section=2" title="Editovat zdrojový kód sekce Úloha hypermodifikácií v stabilizácii RNA"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Bolo navrhnuté, že wybutozín a iné nezvyčajné nukleozidy vedú k jedinému výsledku hypermodifikácie. Táto hypermodifikácia tRNA<sup>Phe</sup> na pozícii 37 umožňuje skladanie báz na seba (stacking), ktoré má dôležitú úlohu v udržiavaní <a href="/wiki/%C4%8C%C3%ADtac%C3%AD_r%C3%A1mec" title="Čítací rámec">čítacieho rámca</a>.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Vďaka veľkým aromatickým skupinám sa zlepšuje skladanie s bázami A36 a A38, čo znižuje flexibilitu antikodónu.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Bolo zistené, že keď tRNA<sup>Phe</sup> nemá wybutozín, dochádza k <a href="/w/index.php?title=Posun_%C4%8D%C3%ADtacieho_r%C3%A1mca&action=edit&redlink=1" class="new" title="Posun čítacieho rámca (stránka neexistuje)">posunu čítacieho rámca</a>. Všeobecne modifikácie na pozícii 37 zabraňujú párovaniu báz so susednými nukleotidmi vďaka udržiavaniu a otvoreniu kruhovej konformácie, ako i tvorbou antikodónového kruhu na dekódovanie. Wybutozínová modifikácia tRNA<sup>Phe</sup> je zachovaná u <a href="/w/index.php?title=Arceh%C3%B3n&action=edit&redlink=1" class="new" title="Arcehón (stránka neexistuje)">arcehónov</a> i eukaryot, ale nenachádza sa u baktérií. Štúdie z rokov 1960-1980 ukázali, že mnoho mutácií môže viesť k problémom s presnou transláciou. Ďalšie štúdie mechanizmov presnosti translácie ukázali dôležitosť modifikácií tRNA na pozíciách 34 a 37. Bez ohľadu na živočíšny druh sú tieto pozície takmer vždy modifikované. To, že wybutozín a jeho rôzne deriváty sa nachádzajú len na pozícii 37, naznačuje povahu fenylalanínových antikodónov, UUU a UUC, a ich náchylnosti k ribozómovému slkzu.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Na základe toho vznikol predpoklad, že modifikácia tRNA<sup>Phe</sup> na pozícii 37 koreluje s množstvom polyuridínových klzkých sekvencií v genómoch.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Potenciál_pre_posun_čítacieho_rámca"><span id="Potenci.C3.A1l_pre_posun_.C4.8D.C3.ADtacieho_r.C3.A1mca"></span>Potenciál pre posun čítacieho rámca</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Wybutoz%C3%ADn&veaction=edit&section=3" title="Upraviť sekciu: Potenciál pre posun čítacieho rámca" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Wybutoz%C3%ADn&action=edit&section=3" title="Editovat zdrojový kód sekce Potenciál pre posun čítacieho rámca"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Úloha wybutozínu v zabránení posunu čítacieho rámca vyvolala otázky ohľadne jeho významu, keďže existujú i iné stratégie proti posunu čítacích rámcov okrem modifikácie s použitím yW. U rodu Drosophila nie je žiadna modifikácia na pozícii 37, ale u cicavcov je na tejto pozícii modifikovaný yW. Na vysvetlenie tejto variability bol navrhnutý potenciál pre posun čítacieho rámcu. Ten naznačuje, že bunky využívajú posun čítacieho rámca na reguláciu a nesnažia sa mu za každú cenu vyhnúť.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Takisto bolo navrhnuté, že bunky využívajú posun čítacieho rámcu predprogramovaným spôsobom, čím sa zvyšuje diverzita. </p> <div class="mw-heading mw-heading2"><h2 id="Referencie">Referencie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Wybutoz%C3%ADn&veaction=edit&section=4" title="Upraviť sekciu: Referencie" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Wybutoz%C3%ADn&action=edit&section=4" title="Editovat zdrojový kód sekce Referencie"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references"><div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> <i>Analógy oligonukleotidov cielené proti ľudskému LMNA - EP 2788487</i> [online]. wbr.indprop.gov.sk, [cit. 2022-02-11]. <a rel="nofollow" class="external text" href="https://wbr.indprop.gov.sk/WebRegistre/EPPatentPreSR/Detail/12805882.3">Dostupné online.</a> </cite></span> </li> <li id="cite_note-Noma-2"><span class="mw-cite-backlink"><a href="#cite_ref-Noma_2-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. <i>EMBO J.</i>, 2006, s. 2142–54. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2Fsj.emboj.7601105">10.1038/sj.emboj.7601105</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/16642040?dopt=Abstract">PMID 16642040</a>. </cite></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Wybutosine biosynthesis: Structural and mechanistic overview. <i>RNA Biology</i>, 2 December 2014, s. 1508–1518. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.4161%2F15476286.2014.992271">10.4161/15476286.2014.992271</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/25629788?dopt=Abstract">PMID 25629788</a>. </cite></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Crystal Structure of the Radical SAM Enzyme Catalyzing Tricyclic Modified Base Formation in tRNA. <i>Journal of Molecular Biology</i>, October 2007, s. 1204–1214. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.jmb.2007.07.024">10.1016/j.jmb.2007.07.024</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/17727881?dopt=Abstract">PMID 17727881</a>. </cite></span> </li> <li id="cite_note-:0-5"><span class="mw-cite-backlink">↑ <a href="#cite_ref-:0_5-0"><sup style="font-style: italic; font-weight: bold; vertical-align: top">a</sup></a> <a href="#cite_ref-:0_5-1"><sup style="font-style: italic; font-weight: bold; vertical-align: top">b</sup></a></span> <span class="reference-text"><cite style="font-style:normal">YOUNG, Anthony P.; BANDARIAN, Vahe. <i>Radical SAM Enzymes</i>. [s.l.] : [s.n.], 2018. <span style="white-space:nowrap"><a href="/wiki/%C5%A0peci%C3%A1lne:Kni%C5%BEn%C3%A9Zdroje/978-0-12-812794-0" title="Špeciálne:KnižnéZdroje/978-0-12-812794-0">ISBN <span class="ISBN">978-0-12-812794-0</span></a></span>. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016/bs.mie.2018.04.024">10.1016/bs.mie.2018.04.024</a> TYW1: A Radical SAM Enzyme Involved in the Biosynthesis of Wybutosine Bases, s. 119–153. </cite></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Practical synthesis of wybutosine, the hypermodified nucleoside of yeast phenylalanine transfer ribonucleic acid. <i>Chem. Pharm. Bull.</i>, 2002, s. 530–3. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1248%2Fcpb.50.530">10.1248/cpb.50.530</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/11964003?dopt=Abstract">PMID 11964003</a>. </cite></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Total synthesis of the hypermodified RNA bases wybutosine and hydroxywybutosine and their quantification together with other modified RNA bases in plant materials. <i>Chemistry</i>, 2013, s. 4244–8. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1002%2Fchem.201204209">10.1002/chem.201204209</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/23417961?dopt=Abstract">PMID 23417961</a>. </cite></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland. <i>Chem. Biol.</i>, 2014, s. 174–85. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.chembiol.2013.10.015">10.1016/j.chembiol.2013.10.015</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/24315934?dopt=Abstract">PMID 24315934</a>. </cite></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Naturally-occurring modification restricts the anticodon domain conformational space of tRNA(Phe). <i>J Mol Biol</i>, 2003, s. 901–18. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.jmb.2003.09.058">10.1016/j.jmb.2003.09.058</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/14643656?dopt=Abstract">PMID 14643656</a>. </cite></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><a href="#cite_ref-10">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Control of catalytic cycle by a pair of analogous tRNA modification enzymes. <i>J Mol Biol</i>, 2010, s. 204–17. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.jmb.2010.05.003">10.1016/j.jmb.2010.05.003</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/20452364?dopt=Abstract">PMID 20452364</a>. </cite></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><a href="#cite_ref-11">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Transfer RNA modifications: nature's combinatorial chemistry playground. <i>Wiley Interdiscip Rev RNA</i>, 2013, s. 35–48. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1002%2Fwrna.1144">10.1002/wrna.1144</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/23139145?dopt=Abstract">PMID 23139145</a>. </cite></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><a href="#cite_ref-12">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Role of a tRNA Base Modification and Its Precursors in Frameshifting in Eukaryotes. <i>Journal of Biological Chemistry</i>, September 2007, s. 26026–26034. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1074%2Fjbc.m703391200">10.1074/jbc.m703391200</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/17623669?dopt=Abstract">PMID 17623669</a>. </cite></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Zdroj">Zdroj</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Wybutoz%C3%ADn&veaction=edit&section=5" title="Upraviť sekciu: Zdroj" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Wybutoz%C3%ADn&action=edit&section=5" title="Editovat zdrojový kód sekce Zdroj"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><span class="plainlinks"><i>Tento článok je čiastočný alebo úplný preklad článku <a class="external text" href="https://en.wikipedia.org/wiki/Wybutosine?oldid=1071303536">Wybutosine</a> na anglickej Wikipédii.</i></span> </p> <div role="navigation" class="navbox" aria-labelledby="Nukleové_kyseliny_a_genetická_informácia" style="padding:3px"><table class="nowraplinks collapsible autocollapse navbox-inner" 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href="/wiki/Deoxyurid%C3%ADn" title="Deoxyuridín">Deoxyuridín</a></li></ul></li></ul> <ul><li>Cukry <ul><li><a href="/wiki/Rib%C3%B3za" title="Ribóza">Ribóza</a></li> <li><a href="/wiki/Deoxyrib%C3%B3za" title="Deoxyribóza">Deoxyribóza</a></li></ul></li></ul> <ul><li>Modifikované nukleozidy <ul><li><a href="/wiki/Dihydrourid%C3%ADn" title="Dihydrouridín">Dihydrouridín</a></li> <li><a href="/wiki/3-Metylurid%C3%ADn" title="3-Metyluridín">3-Metyluridín</a></li> <li><a href="/wiki/5-Metylcytid%C3%ADn" title="5-Metylcytidín">5-Metylcytidín</a></li> <li><a href="/wiki/N6-Metyladenoz%C3%ADn" title="N6-Metyladenozín"><i>N</i><sup>6</sup>-Metyladenozín</a></li> <li><a href="/wiki/Pseudourid%C3%ADn" title="Pseudouridín">Pseudouridín</a></li> <li><a class="mw-selflink selflink">Wybutozín</a></li> <li><a href="/wiki/Wyoz%C3%ADn" title="Wyozín">Wyozín</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nukleotid" title="Nukleotid">Nukleotidy</a></th><td class="navbox-list navbox-odd hlist" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nukleozidmonofosf%C3%A1t" title="Nukleozidmonofosfát">Monofosfáty</a></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Ribonukleotid" class="mw-redirect" title="Ribonukleotid">Ribonukleotidy</a> <ul><li><a href="/wiki/Adenoz%C3%ADnmonofosf%C3%A1t" title="Adenozínmonofosfát">AMP</a></li> <li><a href="/wiki/Cytid%C3%ADnmonofosf%C3%A1t" title="Cytidínmonofosfát">CMP</a></li> <li><a href="/wiki/Guanoz%C3%ADnmonofosf%C3%A1t" title="Guanozínmonofosfát">GMP</a></li> <li><a href="/wiki/Inoz%C3%ADnmonofosf%C3%A1t" title="Inozínmonofosfát">IMP</a></li> <li><a href="/w/index.php?title=5-Metylurid%C3%ADnmonofosf%C3%A1t&action=edit&redlink=1" class="new" title="5-Metyluridínmonofosfát (stránka neexistuje)">m<sup>5</sup>UMP</a></li> <li><a href="/wiki/Urid%C3%ADnmonofosf%C3%A1t" title="Uridínmonofosfát">UMP</a></li> <li><a href="/wiki/Xantoz%C3%ADnmonofosf%C3%A1t" title="Xantozínmonofosfát">XMP</a></li></ul></li></ul> <ul><li><a href="/wiki/Deoxyribonukleotid" class="mw-redirect" title="Deoxyribonukleotid">Deoxyribonukleotidy</a> <ul><li><a href="/wiki/Deoxyadenoz%C3%ADnmonofosf%C3%A1t" title="Deoxyadenozínmonofosfát">dAMP</a></li> <li><a href="/wiki/Deoxycytid%C3%ADnmonofosf%C3%A1t" title="Deoxycytidínmonofosfát">dCMP</a></li> <li><a href="/wiki/Deoxyguanoz%C3%ADnmonofosf%C3%A1t" title="Deoxyguanozínmonofosfát">dGMP</a></li> <li><a href="/wiki/Deoxyinoz%C3%ADnmonofosf%C3%A1t" title="Deoxyinozínmonofosfát">dIMP</a></li> <li><a href="/wiki/Tymid%C3%ADnmonofosf%C3%A1t" title="Tymidínmonofosfát">dTMP</a></li> <li><a href="/wiki/Deoxyurid%C3%ADnmonofosf%C3%A1t" title="Deoxyuridínmonofosfát">dUMP</a></li> <li><a href="/w/index.php?title=Deoxyxantoz%C3%ADnmonofosf%C3%A1t&action=edit&redlink=1" class="new" title="Deoxyxantozínmonofosfát (stránka neexistuje)">dXMP</a></li></ul></li></ul> <ul><li><a href="/wiki/Cyklick%C3%BD_nukleotid" title="Cyklický nukleotid">Cyklické</a> <ul><li><a href="/wiki/Cyklick%C3%BD_adenoz%C3%ADnmonofosf%C3%A1t" title="Cyklický adenozínmonofosfát">cAMP</a></li> <li><a href="/wiki/Cyklick%C3%BD_guanoz%C3%ADnmonofosf%C3%A1t" title="Cyklický guanozínmonofosfát">cGMP</a></li> <li><a href="/wiki/Cyklick%C3%BD_di-AMP" title="Cyklický di-AMP">c-di-AMP</a></li> <li><a href="/wiki/Cyklick%C3%BD_di-GMP" title="Cyklický di-GMP">c-di-GMP</a></li> <li><a href="/wiki/Cyklick%C3%A1_ADP-rib%C3%B3za" title="Cyklická ADP-ribóza">cADPR</a></li> <li><a href="/wiki/Cyklick%C3%BD_guanoz%C3%ADnmonofosf%C3%A1t-adenoz%C3%ADnmonofosf%C3%A1t" title="Cyklický guanozínmonofosfát-adenozínmonofosfát">cGAMP</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nukleoziddifosf%C3%A1t" title="Nukleoziddifosfát">Difosfáty</a></th><td class="navbox-list navbox-even" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Adenoz%C3%ADndifosf%C3%A1t" title="Adenozíndifosfát">ADP</a></li> <li><a href="/wiki/Cytid%C3%ADndifosf%C3%A1t" title="Cytidíndifosfát">CDP</a></li> <li><a href="/wiki/Guanoz%C3%ADndifosf%C3%A1t" title="Guanozíndifosfát">GDP</a></li> <li><a href="/w/index.php?title=Inoz%C3%ADndifosf%C3%A1t&action=edit&redlink=1" class="new" title="Inozíndifosfát (stránka neexistuje)">IDP</a></li> <li><a href="/w/index.php?title=5-Metylurid%C3%ADndifosf%C3%A1t&action=edit&redlink=1" class="new" title="5-Metyluridíndifosfát (stránka neexistuje)">m<sup>5</sup>UDP</a></li> <li><a href="/wiki/Urid%C3%ADndifosf%C3%A1t" title="Uridíndifosfát">UDP</a></li> <li><a href="/wiki/Xantoz%C3%ADndifosf%C3%A1t" title="Xantozíndifosfát">XDP</a></li></ul> <ul><li><a href="/wiki/Deoxyadenoz%C3%ADndifosf%C3%A1t" title="Deoxyadenozíndifosfát">dADP</a></li> <li><a href="/wiki/Deoxycytid%C3%ADndifosf%C3%A1t" title="Deoxycytidíndifosfát">dCDP</a></li> <li><a href="/wiki/Deoxyguanoz%C3%ADndifosf%C3%A1t" title="Deoxyguanozíndifosfát">dGDP</a></li> <li><a href="/w/index.php?title=Deoxyinoz%C3%ADndifosf%C3%A1t&action=edit&redlink=1" class="new" title="Deoxyinozíndifosfát (stránka neexistuje)">dIDP</a></li> <li><a href="/wiki/Tymid%C3%ADndifosf%C3%A1t" title="Tymidíndifosfát">dTDP</a></li> <li><a href="/w/index.php?title=Deoxyurid%C3%ADndifosf%C3%A1t&action=edit&redlink=1" class="new" title="Deoxyuridíndifosfát (stránka neexistuje)">dUDP</a></li> <li><a href="/w/index.php?title=Deoxyxantoz%C3%ADndifosf%C3%A1t&action=edit&redlink=1" class="new" title="Deoxyxantozíndifosfát (stránka neexistuje)">dXDP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nukleozidtrifosf%C3%A1t" title="Nukleozidtrifosfát">Trifosfáty</a></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Adenoz%C3%ADntrifosf%C3%A1t" title="Adenozíntrifosfát">ATP</a></li> <li><a href="/wiki/Cytid%C3%ADntrifosf%C3%A1t" title="Cytidíntrifosfát">CTP</a></li> <li><a href="/wiki/Guanoz%C3%ADntrifosf%C3%A1t" title="Guanozíntrifosfát">GTP</a></li> <li><a href="/wiki/Inoz%C3%ADntrifosf%C3%A1t" title="Inozíntrifosfát">ITP</a></li> <li><a href="/wiki/5-Metylurid%C3%ADntrifosf%C3%A1t" title="5-Metyluridíntrifosfát">m<sup>5</sup>UTP</a></li> <li><a href="/wiki/Urid%C3%ADntrifosf%C3%A1t" title="Uridíntrifosfát">UTP</a></li> <li><a href="/wiki/Xantoz%C3%ADntrifosf%C3%A1t" title="Xantozíntrifosfát">XTP</a></li></ul> <ul><li><a href="/wiki/Deoxyadenoz%C3%ADntrifosf%C3%A1t" title="Deoxyadenozíntrifosfát">dATP</a></li> <li><a href="/wiki/Deoxycytid%C3%ADntrifosf%C3%A1t" title="Deoxycytidíntrifosfát">dCTP</a></li> <li><a href="/wiki/Deoxyguanoz%C3%ADntrifosf%C3%A1t" title="Deoxyguanozíntrifosfát">dGTP</a></li> <li><a href="/w/index.php?title=Deoxyinoz%C3%ADntrifosf%C3%A1t&action=edit&redlink=1" class="new" title="Deoxyinozíntrifosfát (stránka neexistuje)">dITP</a></li> <li><a href="/wiki/Tymid%C3%ADntrifosf%C3%A1t" title="Tymidíntrifosfát">dTTP</a></li> <li><a href="/w/index.php?title=Deoxyurid%C3%ADntrifosf%C3%A1t&action=edit&redlink=1" class="new" title="Deoxyuridíntrifosfát (stránka neexistuje)">dUTP</a></li> <li><a href="/w/index.php?title=Deoxyxantoz%C3%ADntrifosf%C3%A1t&action=edit&redlink=1" class="new" title="Deoxyxantozíntrifosfát (stránka neexistuje)">dXTP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nukleov%C3%A1_kyselina" title="Nukleová kyselina">Nukleové kyseliny</a></th><td class="navbox-list navbox-even hlist" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Deoxyribonukleov%C3%A1_kyselina" title="Deoxyribonukleová kyselina">DNA</a></li> <li><a href="/wiki/Ribonukleov%C3%A1_kyselina" title="Ribonukleová kyselina">RNA</a></li> <li><a href="/w/index.php?title=LNA&action=edit&redlink=1" class="new" title="LNA (stránka neexistuje)">LNA</a></li> <li><a href="/w/index.php?title=PNA&action=edit&redlink=1" class="new" title="PNA (stránka neexistuje)">PNA</a></li> <li><a href="/wiki/Mitochondri%C3%A1lna_DNA" title="Mitochondriálna DNA">mtDNA</a></li> <li><a href="/wiki/Plastidov%C3%A1_DNA" title="Plastidová DNA">ptDNA</a></li> <li><a href="/wiki/Oligonukleotid" title="Oligonukleotid">Oligonukleotid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Genetick%C3%A1_inform%C3%A1cia" title="Genetická informácia">Genetická informácia</a></th><td class="navbox-list navbox-odd hlist" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Antikod%C3%B3n" title="Antikodón">Antikodón</a></li> <li><a href="/w/index.php?title=Epigenetika&action=edit&redlink=1" class="new" title="Epigenetika (stránka neexistuje)">Epigenetika</a></li> <li><a href="/wiki/Gen%C3%B3m" title="Genóm">Genóm</a></li> <li><a href="/wiki/G%C3%A9n" title="Gén">Gén</a></li> <li><a href="/wiki/Genetick%C3%BD_k%C3%B3d" title="Genetický kód">Genetický kód</a></li> <li><a href="/wiki/Kod%C3%B3n" title="Kodón">Kodón</a></li> <li><a href="/wiki/Riboz%C3%BDm" title="Ribozým">Ribozým</a></li></ul> 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