Unlocking Hope: The Promise of Stem Cell Transplantation in Moder

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function googleTranslateElementInit() { new google.translate.TranslateElement({pageLanguage: 'en'}, 'google_translate_element'); } </script> <script type="text/javascript" src="//translate.google.com/translate_a/element.js?cb=googleTranslateElementInit"></script>  <section class="py-4"> <div class="container"> <div class="row"> <div class="col-lg-8"> <div class="row align-items-center justify-content-between"> <div class="col-12 col-sm-6"> <p class="text-muted mb-0"> Short Communication - (2024) Volume 10, Issue 1 </p> </div> <div class="col-12 col-sm-6 text-end"> <ul class="list-unstyled justify-content-end d-flex download"> <li> <a href="https://www.primescholars.com/articles/unlocking-hope-the-promise-of-stem-cell-transplantation-in-modern-medicine.pdf" title="View PDF" class="btn-sm bg-green-600 rounded-50"><i class="fas fa-file-pdf"></i> View PDF</a> </li> <li> <a href="https://www.primescholars.com/pdfdownload.php?download=articles/unlocking-hope-the-promise-of-stem-cell-transplantation-in-modern-medicine.pdf&aid=128135" title="Download PDF" class="btn-sm bg-green-600 rounded-50"><i class="fas fa-download"></i> Download PDF</a> </li> </ul> </div> </div> <h5 class="font-size-7 mt-2">Unlocking Hope: The Promise of Stem Cell Transplantation in Modern Medicine</h5> <a href='https://www.primescholars.com/author/teimo-ashray-57341' title='Teimo Ashray' style='color:#555; border-bottom:1px dotted #CCC;'>Teimo Ashray</a><sup><a href='#Teimo_Ashray'>*</a></sup> <div> </div> Department of Medicine, Yale University, USA<br> <div> </div> <a id="Teimo_Ashray"></a> <strong><sup>*</sup>Correspondence:</strong> Teimo Ashray, Department of Medicine, Yale University, USA, <strong>Email:</strong> <i class='fa fa-envelope' aria-hidden='true' title='ashray@gmail.com'></i> <p> <strong>Received: </strong>28-Feb-2024, Manuscript No. IPISC-24-19999 ; <strong>Editor assigned: </strong>01-Mar-2024, Pre QC No. IPISC-24-19999 (PQ); <strong>Reviewed: </strong>15-Mar-2024, QC No. IPISC-24-19999 ; <strong>Revised: </strong>20-Mar-2024, Manuscript No. IPISC-24-19999 (R); <strong>Published:</strong> 27-Mar-2024, DOI: 10.21767/IPISC.10.1.02</p> <h4 class="font-size-5">Introduction</h4><p>In the landscape of medical treatments, few breakthroughs have offered as much hope and potential as stem cell transplantation. Stem cell transplantation, also known as bone marrow transplantation, has emerged as a cornerstone in the treatment of various cancers, blood disorders, and immune deficiencies, offering patients a chance at renewed health and vitality. This remarkable therapy harnesses the regenerative power of stem cells to replace damaged or diseased cells, paving the way for transformative outcomes in the realm of modern medicine. At its core, stem cell transplantation involves the infusion of healthy stem cells into a patient’s body to replace damaged or diseased cells.</p><h4 class="font-size-5">Description</h4><p>These stem cells can be sourced from bone marrow, peripheral blood, or umbilical cord blood, depending on the specific needs of the patient and the nature of the condition being treated. Stem cell transplantation is employed in the treatment of a diverse range of conditions including Stem cell transplantation is widely used in the treatment of hematologic cancers such as leukaemia, lymphoma, and multiple myeloma. By replacing cancerous cells with healthy stem cells, transplantation offers a chance at remission and long-term disease control. Inherited blood disorders such as sickle cell anaemia, thalassemia, and aplastic anaemia can be effectively treated with stem cell transplantation. By replenishing the patient’s blood-forming cells with healthy donor cells, transplantation can restore normal blood cell production and function. Certain immune deficiencies, such as Severe Combined Immunodeficiency (SCID) and Wiskott-Aldrich Syndrome, can be treated with stem cell transplantation. By providing the patient with a functional immune system derived from donor stem cells, transplantation can prevent recurrent infections and improve overall health. The process of stem cell transplantation typically involves several key steps Before undergoing transplantation, patients may undergo conditioning therapy, which involves high-dose chemotherapy and radiation therapy to destroy diseased cells and suppress the immune system. This creates space within the bone marrow for the donor stem cells to engraft and proliferate. Donor stem cells are collected from bone marrow, peripheral blood, or umbilical cord blood, depending on the source of the cells and the specific requirements of the transplant. Peripheral blood stem cell collection involves the use of apheresis to isolate stem cells from the donor’s bloodstream, while bone marrow and cord blood are collected via aspiration or extraction. This process typically takes several weeks, during which time the patient may require supportive care to prevent complications such as infection and graft-versus-host disease. Once the transplanted stem cells have successfully engrafted and begun to produce healthy blood cells, the patient enters a phase of recovery, during which time their immune system gradually regains strength [1-4].</p><h4 class="font-size-5">Conclusion</h4><p>Patients undergoing stem cell transplantation are highly susceptible to infections due to the suppression of their immune system during the conditioning phase. Close monitoring and prophylactic measures are essential to prevent and manage infections in these vulnerable patients. Despite successful engraftment and initial disease control, some patients may experience disease relapse following stem cell transplantation. Strategies to prevent relapse and improve long-term outcomes are an area of active research and clinical investigation. As our understanding of stem cell biology and transplantation techniques continues to advance, the future of stem cell transplantation holds great promise.</p><h4 class="font-size-5">Acknowledgement</h4><p>None.</p><h4 class="font-size-5">Conflict Of Interest</h4><p>The author’s declared that they have no conflict of interest.</p><h4 class="font-size-5">References</h4><ol> <li id="Reference_Title_Link" value="1"><a id="1" name="1"></a>White I, Yanai H, Slavin M, Naftali T (2024) <a href="https://onlinelibrary.wiley.com/doi/10.1111/codi.16830">Mesenchymal stem cell therapy for Crohn's perianal fistula-a real-world experience.</a> Colorectal Dis. 26(1):102-109. <p>[<a href="https://doi.org/10.1111/codi.16830https:/doi.org/10.1111/codi.16830D:/ISSUE%20RELEASE%20DETAILS/PROOF%20WORK/radiology%20march%20issues/rad%20march%20q1%20files%20PW/10.1016/B978-0-12-397927-8.00004-X">Crossref</a>] [<a href="https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Mesenchymal+stem+cell+therapy+for+Crohn%27s+perianal+fistula-a+real-world+experience&btnG=https://scholar.google.com/scholar?q=Targeting+the+metabolic+microenvironment+of+tumors&hl=en&as_sdt=0%2C5&as_ylo=2012&as_yhi=2012">Google Scholar</a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/38095303/https:/pubmed.ncbi.nlm.nih.gov/38095181/https:/www.tandfonline.com/doi/full/10.1080/1061186X.2023.2295222">PubMed</a>]</p> </li> <li id="Reference_Title_Link" value="2"><a id="2" name="2"></a>Maslennikov S, Avramenko Y, Tumanskyi V, Golovakha M (2024) <a href="https://www.jisakos.com/article/S2059-7754(24)00098-1/fulltexthttps:/pubmed.ncbi.nlm.nih.gov/38095303/https:/pubmed.ncbi.nlm.nih.gov/38095181/https:/www.tandfonline.com/doi/full/10.1080/1061186X.2023.2295222">Comparative characteristics of the stem cells number in the stromal-vascular fraction of infrapatellar fat pad and subcutaneous fat tissue.</a> J ISAKOS. 36(1):106-109. <p>[<a href="https://doi.org/10.1016/j.jisako.2024.05.011">Crossref</a>] [<a href="https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Comparative+Characteristics+Of+The+Stem+Cells+Number+In+The+Stromal-Vascular+Fraction+Of+Infrapatellar+Fat+Pad+And+Subcutaneous+Fat+Tissue&btnG=https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Mesenchymal+stem+cell+therapy+for+Crohn%27s+perianal+fistula-a+real-world+experience&btnG=https://scholar.google.com/scholar?q=Targeting+the+metabolic+microenvironment+of+tumors&hl=en&as_sdt=0%2C5&as_ylo=2012&as_yhi=2012">Google Scholar</a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/38095311/https:/www.jisakos.com/article/S2059-7754(24)00098-1/fulltexthttps:/pubmed.ncbi.nlm.nih.gov/38095303/https:/pubmed.ncbi.nlm.nih.gov/38095181/https:/www.tandfonline.com/doi/full/10.1080/1061186X.2023.2295222">PubMed</a>]</p> </li> <li id="Reference_Title_Link" value="3"><a id="3" name="3"></a>Li H, Yang H, Liu J, Yang H, Qian Q, et al. 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(2024) <a href="https://www.sciencedirect.com/science/article/abs/pii/S0014482724001861?via%3Dihub">α-ketoglutarate preconditioning extends the survival of engrafted adipose-derived mesenchymal stem cells to accelerate healing of burn wounds.</a> Exp Cell Res. 439(1):114095. <p>[<a href="https://doi.org/10.1016/j.yexcr.2024.114095">Crossref</a>] [<a href="https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%CE%B1-ketoglutarate+preconditioning+extends+the+survival+of+engrafted+adipose-derived+mesenchymal+stem+cells+to+accelerate+healing+of+burn+wounds&btnG=">Google Scholar</a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/38759745/">PubMed</a>]</p> </li> </ol> <div class="card bg-light mb-3"> <div class="card-body px-3 pb-0"> <p><strong>Citation:</strong> Ashray T (2024) Unlocking Hope: The Promise of Stem Cell Transplantation in Modern Medicine. Insight Stem Cell. 10:02.</p> <p><strong>Copyright: </strong>© 2024 Ashray T. 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