QUANTIFOIL Holey Carbon Supports for Cryo-EM

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They provide a low-background sample support ideal for high-resolution cryo-EM data collection. The optimum grid for your project can be selected from a wide variety of hole shapes, sizes and spacings in combination with a range of base grid materials and mesh sizes. Grid options include standard square meshes as well as other arrangements and finder grid formats.</p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-4 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1694689175997" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-header" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_widget_1694689175997_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_header" style="" data-hs-cos-general-type="widget" data-hs-cos-type="header"><h5>Quantifoil in peer-reviewed publications</h5></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-5 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1694689143021" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="hs-tabs"> <ul class="hs-tabs__nav"> <li><a href="#tab-1" class="hs-tabs__navitem hs-tabs__navitem--active"><div id="hs_cos_wrapper_widget_1694689143021_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="tab_label">Best practice</div></a></li><li><a href="#tab-2" class="hs-tabs__navitem"><div id="hs_cos_wrapper_widget_1694689143021_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="tab_label">Recently published</div></a></li><li><a href="#tab-3" class="hs-tabs__navitem"><div id="hs_cos_wrapper_widget_1694689143021_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="tab_label">Early results</div></a></li><li><a href="#tab-4" class="hs-tabs__navitem"><div id="hs_cos_wrapper_widget_1694689143021_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="tab_label">Citation list</div></a></li> </ul> <div id="tab-1" class="hs-tabs__item hs-tabs__item--active"><div id="hs_cos_wrapper_widget_1694689143021_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="content"><p>Methods and review publications describing best practice in the field include:</p> <p>Passmore and Russo. Specimen preparation for high-resolution cryo-EM.<a href="https://doi.org/10.1016%2Fbs.mie.2016.04.011" rel="noopener" target="_blank"> <em>Methods Enzymol.</em> <strong>579</strong>: 510-86 (2016)</a></p> <p>Drulyte<em> et al</em>. Approaches to altering particle distributions in cryo-electron microscopy sample preparation. <a href="https://doi.org/10.1107%2FS2059798318006496" rel="noopener" target="_blank"><em>Acta Cryst D</em><strong>74</strong>: 560-571 (2018)</a></p> <p>Koh et al. Routine Collection of High-Resolution cryo-EM Datasets Using 200 KV Transmission Electron Microscope.<em> </em><a href="https://doi.org/10.3791/63519" rel="noopener" target="_blank"><em>J Vis Exp</em> <strong>181</strong> (2022)</a></p></div></div> <div id="tab-2" class="hs-tabs__item"><div id="hs_cos_wrapper_widget_1694689143021_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="content"><p>CryoEM structures recently published in high impact journals include:</p> <p>Arseni <em>et al</em>. TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.<a href="https://doi.org/10.1038/s41586-023-06405-w" rel="noopener"> <em>Nature</em> <strong>620</strong>: 898-902 (2023)</a></p> <p>Baggen <em>et al</em>. TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.<a href="https://doi.org/10.1016/j.cell.2023.06.005" rel="noopener" target="_blank"> <em>Cell</em> <strong>186</strong>:3427-3442 (2023)</a></p></div></div> <div id="tab-3" class="hs-tabs__item"><div id="hs_cos_wrapper_widget_1694689143021_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="content"><p>Highly-cited articles from the first development of hihg-resolution cryoEM for biological specimens include:</p> <p>Li et al. Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. <a href="https://doi.org/10.1038/nmeth.2472" rel="noopener" target="_blank"><em>Nat Methods.</em> <strong>10</strong>: 5840590 (2013)</a></p> <p>Chen et al. High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy. <a href="https://doi.org/10.1016/j.ultramic.2013.06.004" rel="noopener" target="_blank"><em>Ultramicroscopy</em> <strong>135</strong>: 24-35 (2013)</a></p> <p> </p></div></div> <div id="tab-4" class="hs-tabs__item"><div id="hs_cos_wrapper_widget_1694689143021_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="content"><p>QUANTIFOIL© Holey Carbon supports have been cited in approximately 6,000 peer-reviewed publications to date. </p> <p><span class="hs-cta-wrapper" id="hs-cta-wrapper-6b46cd40-dd6e-4185-9bf1-837d03933384"><span class="hs-cta-node hs-cta-6b46cd40-dd6e-4185-9bf1-837d03933384" id="hs-cta-6b46cd40-dd6e-4185-9bf1-837d03933384"><a href="https://hubspot-cta-redirect-eu1-prod.s3.amazonaws.com/cta/redirect/25689746/6b46cd40-dd6e-4185-9bf1-837d03933384"><img class="hs-cta-img" id="hs-cta-img-6b46cd40-dd6e-4185-9bf1-837d03933384" style="border-width:0px;margin: 0 auto; display: block; margin-top: 20px; margin-bottom: 20px" src="https://hubspot-no-cache-eu1-prod.s3.amazonaws.com/cta/default/25689746/6b46cd40-dd6e-4185-9bf1-837d03933384.png" alt="Download the complete list" align="middle"></a></span><script charset="utf-8" src="/hs/cta/cta/current.js"></script><script type="text/javascript"> hbspt.cta._relativeUrls=true;hbspt.cta.load(25689746, '6b46cd40-dd6e-4185-9bf1-837d03933384', {"useNewLoader":"true","region":"eu1"}); </script></span></p></div></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-6 main_area-row-2-max-width-section-centering dnd-section main_area-row-2-vertical-alignment"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell main_area-column-2-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-7 main_area-column-2-row-0-padding main_area-column-2-row-0-margin dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div class="product-card-module anchor-point" id="product-card-module"> <div class="container bullet-list-points"> <div class="text-module bullet-list-points"> <h2>QUANTIFOIL<sup>®</sup> Grid categories</h2> </div> <div class="p-card-module-inr"> <div class="product-card left-card d-flex align-items-center"> <div class="product-card-text pad-r75"> <h3>Circular</h3> <p><span>Ideal for high-resolution studies of biological macromolecules and other materials, round holes optimize the formation of a thin, even layer of ice to support a sample of interest. Select from our wide range of geometries depending on the characteristics of your sample and your imaging modality.</span></p> <a class="btn" href="https://www.quantifoil.com/products/quantifoil/quantifoil-circular-holes"> Explore circular holes </a> </div> <div class="product-card-img"> <img src="https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-circular.jpg?width=487&height=400&name=QUANTIFOIL-circular.jpg" alt="QUANTIFOIL-circular" loading="lazy" width="487" height="400" srcset="https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-circular.jpg?width=244&height=200&name=QUANTIFOIL-circular.jpg 244w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-circular.jpg?width=487&height=400&name=QUANTIFOIL-circular.jpg 487w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-circular.jpg?width=731&height=600&name=QUANTIFOIL-circular.jpg 731w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-circular.jpg?width=974&height=800&name=QUANTIFOIL-circular.jpg 974w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-circular.jpg?width=1218&height=1000&name=QUANTIFOIL-circular.jpg 1218w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-circular.jpg?width=1461&height=1200&name=QUANTIFOIL-circular.jpg 1461w" sizes="(max-width: 487px) 100vw, 487px"> </div> </div> <div class="product-card d-flex align-items-center"> <div class="product-card-img"> <img src="https://www.quantifoil.com/hs-fs/hubfs/S7-2-2-small.jpeg?width=521&height=521&name=S7-2-2-small.jpeg" alt="S7-2-2-small" loading="lazy" width="521" height="521" srcset="https://www.quantifoil.com/hs-fs/hubfs/S7-2-2-small.jpeg?width=261&height=261&name=S7-2-2-small.jpeg 261w, https://www.quantifoil.com/hs-fs/hubfs/S7-2-2-small.jpeg?width=521&height=521&name=S7-2-2-small.jpeg 521w, https://www.quantifoil.com/hs-fs/hubfs/S7-2-2-small.jpeg?width=782&height=782&name=S7-2-2-small.jpeg 782w, https://www.quantifoil.com/hs-fs/hubfs/S7-2-2-small.jpeg?width=1042&height=1042&name=S7-2-2-small.jpeg 1042w, https://www.quantifoil.com/hs-fs/hubfs/S7-2-2-small.jpeg?width=1303&height=1303&name=S7-2-2-small.jpeg 1303w, https://www.quantifoil.com/hs-fs/hubfs/S7-2-2-small.jpeg?width=1563&height=1563&name=S7-2-2-small.jpeg 1563w" sizes="(max-width: 521px) 100vw, 521px"> </div> <div class="product-card-text pad-l75"> <h3>Square</h3> <p><span>Often used for applications where larger carbon-free areas are desired, square grids have less carbon support. They can be used with an additional thin carbon layer where samples need continuous support.</span></p> <a class="btn" href="https://www.quantifoil.com/products/quantifoil/quantifoil-square-holes"> Explore square holes </a> </div> </div> <div class="product-card left-card d-flex align-items-center"> <div class="product-card-text pad-r75"> <h3>Multi A</h3> <p>With a repeating pattern of hole size, shape and spacing, Multi A foils are useful for particles of unpredictable size, for example liposomes, while the oval shape can aid in tomographic data collection.</p> <a class="btn" href="https://www.quantifoil.com/products/quantifoil/quantifoil-multi"> Explore Multi A holes </a> </div> <div class="product-card-img"> <img src="https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-multi.jpg?width=487&height=400&name=QUANTIFOIL-multi.jpg" alt="QUANTIFOIL-multiA" loading="lazy" width="487" height="400" srcset="https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-multi.jpg?width=244&height=200&name=QUANTIFOIL-multi.jpg 244w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-multi.jpg?width=487&height=400&name=QUANTIFOIL-multi.jpg 487w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-multi.jpg?width=731&height=600&name=QUANTIFOIL-multi.jpg 731w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-multi.jpg?width=974&height=800&name=QUANTIFOIL-multi.jpg 974w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-multi.jpg?width=1218&height=1000&name=QUANTIFOIL-multi.jpg 1218w, https://www.quantifoil.com/hs-fs/hubfs/Website/4.0%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-multi.jpg?width=1461&height=1200&name=QUANTIFOIL-multi.jpg 1461w" sizes="(max-width: 487px) 100vw, 487px"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-8 main_area-row-3-margin main_area-row-3-max-width-section-centering main_area-row-3-vertical-alignment dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget main_area-module-4-vertical-alignment dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div class="home-section4" id=""> <div class="container"> <div class="home-section4-inner" style="background-image:url('https://www.quantifoil.com/hubfs/Website/r12-13-mid.jpg')"> <div class="banner-overlay"> <div class="flex"> <div class="sec4-content"> <div class="sec4-heading">How to prepare QUANTIFOIL<sup>®</sup> holey carbon film supports</div> <p>Suggested protocols to maximize the quality and reproducibility of samples when using QUANTIFOIL<sup>®</sup> grids.</p> <div style="float: right;"> <a class="btn white" href="https://www.quantifoil.com/resources/preparing-quantifoil-grids-use">Read more</a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div data-global-resource-path="Quantifoil-Theme-2022/templates/partials/footer.html"><footer class="footer"> <div class="container"> <div class="container-fluid footer-inr"> <div class="row-fluid-wrapper"> <div class="row-fluid"> <div class="span12 widget-span widget-type-cell " style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-1 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-2 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div class="ftr-btm-sec d-flex justify-content-between align-items-center"> <ul class="links d-flex"> <li> <a href="https://www.quantifoil.com/privacy"> Privacy Notice & Cookies </a></li> <li> <a href="https://www.quantifoil.com/impressum"> Impressum </a></li> </ul> <span>© 2024 Quantifoil Micro Tools GmbH - 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QUANTIFOIL Holey Carbon Supports for Cryo-EM | Quantifoil