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KEGG ENZYME: 1.14.14.55
<!doctype html> <html><head> <title>KEGG ENZYME: 1.14.14.55</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1744376362"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1744376362"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1744376362" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « 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enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr2 w1"> <table width="650" class="w2"> <tr><th class="th20 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td20 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">EC 1.14.14.55 Enzyme <br> </span></code></td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td21 defd"><div class="cel"><div class="cel">quinine 3-monooxygenase;<br> CYP3A4 (gene name)<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td20 defd"><div class="cel">Oxidoreductases;<br> Acting on paired donors, with incorporation or reduction of molecular oxygen;<br> With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor<br> <button class="btn" onclick="location.href='/brite/ko01000+1.14.14.55';return false;">BRITE hierarchy</button></div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Sysname</span></th> <td class="td21 defd"><div class="cel">quinine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reaction(IUBMB)</span></th> <td class="td20 defd"><div class="cel">quinine + [reduced NADPH---hemoprotein reductase] + O2 = 3-hydroxyquinine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:<a href="/entry/R05727">R05727</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reaction(KEGG)</span></th> <td class="td21 defd"><div class="cel"><a href="/entry/R05727">R05727</a><br> <button class="btn" onclick="location.href='/entry/R05727';return false;">Reaction</button></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Substrate</span></th> <td class="td20 defd"><div class="cel">quinine [CPD:<a href="/entry/C06526">C06526</a>];<br> [reduced NADPH---hemoprotein reductase] [CPD:<a href="/entry/C03024">C03024</a>];<br> O2 [CPD:<a href="/entry/C00007">C00007</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td21 defd"><div class="cel"><div class="cel">3-hydroxyquinine [CPD:<a href="/entry/C07344">C07344</a>];<br> [oxidized NADPH---hemoprotein reductase] [CPD:<a href="/entry/C03161">C03161</a>];<br> H2O [CPD:<a href="/entry/C00001">C00001</a>]<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td20 defd"><div class="cel">A cytochrome P-450 (heme-thiolate) protein.<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">History</span></th> <td class="td21 defd"><div class="cel">EC 1.14.14.55 created 2000 as EC 1.14.13.67, transferred 2017 to EC 1.14.14.55<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Orthology</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K17689">K17689</a> </span></td><td>cytochrome P450 family 3 subfamily A4</td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Genes</span></th> <td class="td21 defd"><style>span.g1a{color:#003399}span.g1a:hover{color:#33cc99;cursor:pointer;}div.g1{display:none;}</style><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g11">HSA</span>: </span></td><td id="g11d">1576(CYP3A4)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g12">PTR</span>: </span></td><td id="g12d">463582(CYP3A4)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g13">PPS</span>: </span></td><td id="g13d">100976899(CYP3A4)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g14">GGO</span>: </span></td><td id="g14d">101149513</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g15">PON</span>: </span></td><td id="g15d">100436782</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g16">PPYG</span>: </span></td><td id="g16d">129041698</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g17">NLE</span>: </span></td><td id="g17d">100593175</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g18">SSYN</span>: </span></td><td id="g18d">129489604</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g19">MCC</span>: </span></td><td id="g19d">678670(CYP3A4)</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g110">MCF</span>: </span></td><td id="g110d">102144258(CYP3A4)</td></tr></table><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g111">MTHB</span>: </span></td><td id="g111d">126950475</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g112">MNI</span>: </span></td><td id="g112d">105497389</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g113">CSAB</span>: </span></td><td id="g113d">103246766</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g114">CATY</span>: </span></td><td id="g114d">105584402</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g115">PANU</span>: </span></td><td id="g115d">101026757</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g116">TGE</span>: </span></td><td id="g116d">112621193</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g117">MLEU</span>: </span></td><td id="g117d">105543708</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g118">RRO</span>: </span></td><td id="g118d">104673585</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g119">RBB</span>: </span></td><td id="g119d">108538168</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g120">TFN</span>: </span></td><td id="g120d">117072034</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g121">PTEH</span>: </span></td><td id="g121d">111530171 111534893</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g122">CANG</span>: </span></td><td id="g122d">105513064</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g123">CJC</span>: </span></td><td id="g123d">100404344(CYP3A4)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g124">SBQ</span>: </span></td><td id="g124d">101037403</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g125">CIMI</span>: </span></td><td id="g125d">108308036(CYP3A4)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g126">ANAN</span>: </span></td><td id="g126d">105719456(CYP3A4)</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g127">CSYR</span>: </span></td><td id="g127d">103252931</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g128">MMUR</span>: </span></td><td id="g128d">105868328 105868331</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g129">LCAT</span>: </span></td><td id="g129d">123631591 123631593</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g130">PCOQ</span>: </span></td><td id="g130d">105806078</td></tr></table></div><div class="g1"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><span class="g1a" id="g131">OGA</span>: </span></td><td id="g131d">100948865</td></tr></table></div><a href="javascript:void(0)" onclick="javascript:toggleField(this,"g1","show all","hide")"> » show all</a><br> <script>for(var i=1;i<=31;i++){if(document.getElementById('g1'+i)){document.getElementById('g1'+i).onclick = function(e){geg1(this,e);};}}function geg1(bobj){var id = bobj.id;var ab = document.getElementById(id).innerText;var dt = document.getElementById(id+'d');var st = dt.innerText.replace(/\([^\)]+\)/g,'').replace(/ /g,'+');var gt = '/entry/'+ab+'+'+st;location.href = gt;}</script><input type="hidden" name="query" form="form1" value="HSA PTR PPS GGO PON PPYG NLE SSYN MCC MCF MTHB MNI CSAB CATY PANU TGE MLEU RRO RBB TFN PTEH CANG CJC SBQ CIMI ANAN CSYR MMUR LCAT PCOQ OGA"><input type="hidden" name="htext" form="form1" value="br08601.keg"><input type="hidden" name="option" form="form1" value="-a"><button class="btn" onclick="javascript:go_taxonomy(document.form1,{"action":"https://www.kegg.jp/kegg-bin/search_htext"});return false;">Taxonomy</button></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">1 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/1578365">1578365</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Relling MV, Evans R, Dass C, Desiderio DM, Nemec J.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">Human cytochrome P450 metabolism of teniposide and etoposide.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">J Pharmacol Exp Ther 261:491-6 (1992)</div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">2 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/9088578">9088578</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">Br J Clin Pharmacol 43:245-52 (1997)<br>DOI:<a href="https://doi.org/10.1046/j.1365-2125.1997.00556.x">10.1046/j.1365-2125.1997.00556.x</a></div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Sequence</span></th> <td class="td20 repd"><div class="cel">[hsa:<a href="/entry/hsa:1576">1576</a>]</div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td21 defd"><div class="cel">3 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/9456308">9456308</a>]</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td20 repd"><div class="cel">Zhao XJ, Kawashiro T, Ishizaki T.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td21 repd"><div class="cel">Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td20 repd"><div class="cel">Drug Metab Dispos 26:188-91 (1998)</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Sequence</span></th> <td class="td21 repd"><div class="cel">[hsa:<a href="/entry/hsa:1576">1576</a>]</div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">4 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/8968357">8968357</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">J Pharmacol Exp Ther 279:1327-34 (1996)</div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExplorEnz - The Enzyme Database: </span></td><td><a href="https://www.enzyme-database.org/query.php?ec=1.14.14.55">1.14.14.55</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">IUBMB Enzyme Nomenclature: </span></td><td><a href="https://iubmb.qmul.ac.uk/enzyme/EC1/14/14/55.html">1.14.14.55</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExPASy - ENZYME nomenclature database: </span></td><td><a href="https://enzyme.expasy.org/EC/1.14.14.55">1.14.14.55</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">BRENDA, the Enzyme Database: </span></td><td><a href="https://www.brenda-enzymes.info/enzyme.php?ecno=1.14.14.55">1.14.14.55</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>50812-30-1 213327-78-7</td></tr></table></td></tr> </table></td></tr></table> <br></td><td class="vtop"><div class="aw" style="margin-top:46px;"><div class="fm at th20"> All links </div> <div class="fm"><pre class="fm" style="margin-left:1em"> <span style="color:#006"><a href="/dbget-bin/get_linkdb?-t+10+ec:1.14.14.55">Protein sequence (5)</a></span> <a href="/dbget-bin/get_linkdb?-t+uniprot+ec:1.14.14.55">UniProt (1)</a> <a href="/dbget-bin/get_linkdb?-t+swissprot+ec:1.14.14.55">SWISS-PROT (1)</a> <a href="/dbget-bin/get_linkdb?-t+refpep+ec:1.14.14.55">RefSeq(pep) (3)</a> <span style="color:#006"><a href="/dbget-bin/get_linkdb?-t+11+ec:1.14.14.55">DNA sequence (5)</a></span> <a href="/dbget-bin/get_linkdb?-t+refnuc+ec:1.14.14.55">RefSeq(nuc) (5)</a> <span style="color:#006"><a href="/dbget-bin/get_linkdb?-t+13+ec:1.14.14.55">Protein domain (6)</a></span> <a href="/dbget-bin/get_linkdb?-t+interpro+ec:1.14.14.55">InterPro (6)</a> <a href="/dbget-bin/get_linkdb?-t+alldb+ec:1.14.14.55">All databases (16)</a> <br><a href="/dbget-bin/get_linkdb?-N+ec:1.14.14.55">Download RDF</a> </pre> </div></div> </td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>