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post-translational modifications</title> <meta name="description" content="Search results for: post-translational modifications"> <meta name="keywords" content="post-translational modifications"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research 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method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="post-translational modifications"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 514</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: post-translational modifications</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">514</span> Posttranslational Modifications of Histone H3 in Tumor Tissue Isolated from Silver and Gold Nanoparticles Treated Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lucyna%20Kapka-Skrzypczak">Lucyna Kapka-Skrzypczak</a>, <a href="https://publications.waset.org/abstracts/search?q=Barbara%20Sochanowicz"> Barbara Sochanowicz</a>, <a href="https://publications.waset.org/abstracts/search?q=Magdalena%20Matysiak-Kucharek"> Magdalena Matysiak-Kucharek</a>, <a href="https://publications.waset.org/abstracts/search?q=Magdalena%20Czajka"> Magdalena Czajka</a>, <a href="https://publications.waset.org/abstracts/search?q=Krzysztof%20Sawicki"> Krzysztof Sawicki</a>, <a href="https://publications.waset.org/abstracts/search?q=Marcin%20Kruszewski"> Marcin Kruszewski</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Due to the strong antimicrobial activity silver nanoparticles (AgNPs) are widely used in various medical and general applications, among others, in cosmetics, odour resistant textiles, etc. The aim of this study was to compare effect of AgNPs and gold NPs (AuNPs) on histones posttranslational modifications. Histone molecule posttranscriptional modifications are responsible for chromatin compaction and repackaging. In this study, BALB/c mice were inoculated with murine mammary carcinoma 4T1 cells and treated with AgNPs coated with citrate (AgNPs(cit) or PEG (AgNPs(PEG), or AuNPs. Thereafter the histone H3 acetylation on Lys9 and H3 methylation on Lys4, Lys9, Lys29 was investigated. All NPs tested decreased H3 methylation, while no effect was observed for H3 acetylation. Modification of histone H3 methylation dependent on type of NPs used its coating, site of methylation and treatment used. Conclusion, epigenetic effects of nanomaterials depend on nanomaterial composition, its coating, and way of application. This work was supported by National Science Centre grant No. 2014/15/B/NZ7/01036 (MK, LKS, MMK, MC, KS), statutory funding for INTC (BS). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gold%20nanoparticles" title="gold nanoparticles">gold nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=histone" title=" histone"> histone</a>, <a href="https://publications.waset.org/abstracts/search?q=methylation" title=" methylation"> methylation</a>, <a href="https://publications.waset.org/abstracts/search?q=silver%20nanoparticles" title=" silver nanoparticles"> silver nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/108255/posttranslational-modifications-of-histone-h3-in-tumor-tissue-isolated-from-silver-and-gold-nanoparticles-treated-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/108255.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">200</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">513</span> Molecular Portraits: The Role of Posttranslational Modification in Cancer Metastasis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Navkiran%20Kaur">Navkiran Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Apoorva%20Mathur"> Apoorva Mathur</a>, <a href="https://publications.waset.org/abstracts/search?q=Abhishree%20Agarwal"> Abhishree Agarwal</a>, <a href="https://publications.waset.org/abstracts/search?q=Sakshi%20Gupta"> Sakshi Gupta</a>, <a href="https://publications.waset.org/abstracts/search?q=Tuhin%20Rashmi"> Tuhin Rashmi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: Breast cancer is the most common cancer in women worldwide, and resistance to the current therapeutics, often concurrently, is an increasing clinical challenge. Glycosylation of proteins is one of the most important post-translational modifications. It is widely known that aberrant glycosylation has been implicated in many different diseases due to changes associated with biological function and protein folding. Alterations in cell surface glycosylation, can promote invasive behavior of tumor cells that ultimately lead to the progression of cancer. In breast cancer, there is an increasing evidence pertaining to the role of glycosylation in tumor formation and metastasis. In the present study, an attempt has been made to study the disease associated sialoglycoproteins in breast cancer by using bioinformatics tools. The sequence will be retrieved from UniProt database. A database in the form of a word document was made by a collection of FASTA sequences of breast cancer gene sequence. Glycosylation was studied using yinOyang tool on ExPASy and Differential genes expression and protein analysis was done in context of breast cancer metastasis. The number of residues predicted O-glc NAc threshold containing 50 aberrant glycosylation sites or more was detected and recorded for individual sequence. We found that the there is a significant change in the expression profiling of glycosylation patterns of various proteins associated with breast cancer. Differential aberrant glycosylated proteins in breast cancer cells with respect to non-neoplastic cells are an important factor for the overall progression and development of cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=bioinformatics" title=" bioinformatics"> bioinformatics</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=metastasis" title=" metastasis"> metastasis</a>, <a href="https://publications.waset.org/abstracts/search?q=glycosylation" title=" glycosylation"> glycosylation</a> </p> <a href="https://publications.waset.org/abstracts/68966/molecular-portraits-the-role-of-posttranslational-modification-in-cancer-metastasis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/68966.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">294</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">512</span> Mechanical Properties of Young and Senescence Fibroblast Cells Using Passive Microrheology</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Samira%20Khalaji">Samira Khalaji</a>, <a href="https://publications.waset.org/abstracts/search?q="> </a>, <a href="https://publications.waset.org/abstracts/search?q=Fenneke%20Klein%20Jan"> Fenneke Klein Jan</a>, <a href="https://publications.waset.org/abstracts/search?q=Kay-E.%20Gottschalk"> Kay-E. Gottschalk</a>, <a href="https://publications.waset.org/abstracts/search?q=Eugenia%20Makrantonaki"> Eugenia Makrantonaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Karin%20Scharffetter-Kochanek"> Karin Scharffetter-Kochanek </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biological aging is a multi-dimensional process that takes place over a whole range of scales from the nanoscopic alterations within individual cells, over transformations in tissues and organs and to changes of the whole organism. On the single cell level, aging involves mutation of genes, differences in gene expression levels as well as altered posttranslational modifications of proteins. A variety of proteins is affected, including proteins of the cell cytoskeleton and migration machinery. Previous work quantified the expression of cytoskeleton proteins on the gene and protein levels in senescent and young fibroblasts. Their results show that senescent skin fibroblasts have an upregulated expression of the intermediate filament (IF) protein vimentin in contrast to actin and tubulin, which are downregulated. IFs play an important role in providing mechanical stability of cells. However, the mechanical properties of IFs depending on cellular senescence or age of the donor has not been studied so far. Hence, we employed passive microrheology on primary human dermal fibroblasts from female donors with age of 28 years (young) and 86 years (old) as model of in vivo aging and human normal dermal fibroblast from 11-year old male with CPD 17-35 (young) and CPD 58-59 (senescence) as a model of in vitro replicative senescence. In contrast to the expectations, our primary results show no significant differences in the viscoelastic properties of fibroblasts depending on age of the donor or cellular replicative senescence. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aging" title="aging">aging</a>, <a href="https://publications.waset.org/abstracts/search?q=cytoskeleton" title=" cytoskeleton"> cytoskeleton</a>, <a href="https://publications.waset.org/abstracts/search?q=fibroblast" title=" fibroblast"> fibroblast</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanical%20properties" title=" mechanical properties"> mechanical properties</a> </p> <a href="https://publications.waset.org/abstracts/46654/mechanical-properties-of-young-and-senescence-fibroblast-cells-using-passive-microrheology" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46654.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">322</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">511</span> Minimize Wear and Tear in Y12 Aircraft Tyres</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20D.%20Hiripitiya">N. D. Hiripitiya</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20V.%20H.%20De%20Soysa"> H. V. H. De Soysa</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20S.%20U.%20Thrimavithana"> H. S. U. Thrimavithana</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20R.%20Epitawala"> B. R. Epitawala</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20A.%20D.%20D.%20Kuruppu"> K. A. D. D. Kuruppu</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20J.%20K.%20Lokupathirage"> D. J. K. Lokupathirage</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research was related to identify the reasons which lead for early wear and tear of aircraft tyres. Further this research focused to rectify those issues in tyres with some modifications. The aircraft tyres of Y12 aircraft was selected for the study as due to Y12 aircraft fly frequently. Self-structured questionnaire was prepared and it was distributed among Y12 aircraft technicians. Based on their feedback several issues were identified related to tyre wear and tear. One of the reasons was uneven tyre wearing. But it could rectify after interchanging the tyre sides after completion of 50 landings. Several modifications were done in order to rectify all the identified issues. Several devices were constructed in order to enhance the life time of the Y12 aircraft tyre. Mechanical properties were measured for the worn-out tyres. The properties were compared with the control tyre sample. It was found that there was an average increment of tensile strength by 38.14 % of control tyre, when compared with the worn-out tyres which were completed 50 number of landings. The suggested modifications are in the process of implementation. It is confident that above mentioned solutions will lead to increase the life span of tyres in Y12 aircraft. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aircraft" title="aircraft">aircraft</a>, <a href="https://publications.waset.org/abstracts/search?q=devices" title=" devices"> devices</a>, <a href="https://publications.waset.org/abstracts/search?q=enhance%20life%20span" title=" enhance life span"> enhance life span</a>, <a href="https://publications.waset.org/abstracts/search?q=modifications%20for%20tyre%20wear" title=" modifications for tyre wear"> modifications for tyre wear</a> </p> <a href="https://publications.waset.org/abstracts/57455/minimize-wear-and-tear-in-y12-aircraft-tyres" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/57455.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">292</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">510</span> The Impact of Text Modifications on Ethiopian Students’ Reading Comprehension and Motivation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Asefa%20Kenefergib">Asefa Kenefergib</a>, <a href="https://publications.waset.org/abstracts/search?q=Dawit%20Amogne"> Dawit Amogne</a>, <a href="https://publications.waset.org/abstracts/search?q=Yinager%20Teklesellassie"> Yinager Teklesellassie</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A study investigated the effects of text modifications on reading comprehension and motivation among Ethiopian secondary school students. A total of 120 students participated, initially taking a reading comprehension pretest and completing a reading motivation questionnaire. Afterward, they were divided into three groups: control, simplified, and elaborated. Each group then took part in a reading comprehension posttest and another reading motivation questionnaire following an eight-week instructional intervention. Despite initial differences, both the simplified and elaborated text groups showed comparable levels of reading motivation and comprehension. The data were analyzed using SPSS version 25, with a one-way ANOVA used to assess the effectiveness of the modified texts in enhancing reading comprehension. The results indicated that the experimental groups performed significantly better on the posttest compared to the control group, suggesting that text modifications can positively influence students' comprehension skills. Furthermore, the impact of text modifications on student reading motivation was assessed using a one-way ANOVA. The findings revealed that both the elaborated and simplified text groups scored higher than the control group in various dimensions of reading motivation, including reading efficacy, curiosity, challenge, compliance, and reading work avoidance. However, the control and simplified groups had nearly similar mean scores in the dimension of reading competition. These results clearly demonstrate that modifying texts can enhance EFL learners' reading motivation and comprehension. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=simplification" title="simplification">simplification</a>, <a href="https://publications.waset.org/abstracts/search?q=elaboration" title=" elaboration"> elaboration</a>, <a href="https://publications.waset.org/abstracts/search?q=reading%20motivation" title=" reading motivation"> reading motivation</a>, <a href="https://publications.waset.org/abstracts/search?q=reading%20comprehension" title=" reading comprehension"> reading comprehension</a> </p> <a href="https://publications.waset.org/abstracts/187953/the-impact-of-text-modifications-on-ethiopian-students-reading-comprehension-and-motivation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187953.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">43</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">509</span> Peak Floor Response for Buildings with Flexible Base</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Luciano%20Roberto%20Fernandez-Sola">Luciano Roberto Fernandez-Sola</a>, <a href="https://publications.waset.org/abstracts/search?q=Cesar%20Augusto%20Arredondo-Velez"> Cesar Augusto Arredondo-Velez</a>, <a href="https://publications.waset.org/abstracts/search?q=Miguel%20Angel%20Jaimes-Tellez"> Miguel Angel Jaimes-Tellez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper explores the modifications on peak acceleration, velocity and displacement profiles over the structure due to dynamic soil-structure interaction (DSSI). A shear beam model is used for the structure. Soil-foundation flexibility (inertial interaction) is considered by a set of springs and dashpots at the structure base. Kinematic interaction is considered using transfer functions. Impedance functions are computed using simplified expressions for rigid foundations. The research studies the influence of the slenderness ratio on the value of the peak floor response. It is shown that the modifications of peak floor responses are not the same for acceleration, velocity and displacement. This is opposite to the hypothesis used by methods included in several building codes. Results show that modifications produced by DSSI on different response quantities are not equal. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=peak%20floor%20intensities" title="peak floor intensities">peak floor intensities</a>, <a href="https://publications.waset.org/abstracts/search?q=dynamic%20soil-structure%20interaction" title=" dynamic soil-structure interaction"> dynamic soil-structure interaction</a>, <a href="https://publications.waset.org/abstracts/search?q=buildings%20with%20flexible%20base" title=" buildings with flexible base"> buildings with flexible base</a>, <a href="https://publications.waset.org/abstracts/search?q=kinematic%20and%20inertial%20interaction" title=" kinematic and inertial interaction"> kinematic and inertial interaction</a> </p> <a href="https://publications.waset.org/abstracts/65705/peak-floor-response-for-buildings-with-flexible-base" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65705.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">451</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">508</span> Diet-Induced Epigenetic Transgenerational Inheritance</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gaby%20Fahmy">Gaby Fahmy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The last decades have seen a rise in metabolic disorders like diabetes, obesity, and fatty liver disease around the world. Environmental factors, especially nutrition, have contributed to this increase. Additionally, pre-conceptional parental nutritional choices have been shown to result in epigenetic modifications affecting gene expression during the developmental process in-utero. These epigenetic modifications have also been seen to extend to the following offspring in a trans-generational effect. This further highlights the significance and relevance of epigenetics and epigenetic tags, which were previously thought to be stripped in newly formed embryos. Suitable prenatal nutrition may partially counteract adverse outcomes caused by exposures to environmental contaminants, ultimately resulting in improved metabolic profiles like body weight and glucose homeostasis. This was seen in patients who were given dietary interventions like restrictive caloric intake, intermittent fasting, and time-restricted feeding. Changes in nutrition are pivotal in the regulation of epigenetic modifications that are transgenerational. For example, dietary choices such as fatty foods vs. vegetables and nuts in fathers were shown to significantly affect sperm motility and volume. This was pivotal in understanding the importance of paternal inheritance. Further research in the field is needed as it remains unclear how many generations are affected by these changes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=epigenetics" title="epigenetics">epigenetics</a>, <a href="https://publications.waset.org/abstracts/search?q=transgenerational" title=" transgenerational"> transgenerational</a>, <a href="https://publications.waset.org/abstracts/search?q=diet" title=" diet"> diet</a>, <a href="https://publications.waset.org/abstracts/search?q=fasting" title=" fasting"> fasting</a> </p> <a href="https://publications.waset.org/abstracts/156197/diet-induced-epigenetic-transgenerational-inheritance" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156197.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">96</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">507</span> CFD Simulations to Study the Cooling Effects of Different Greening Modifications </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=An-Shik%20Yang">An-Shik Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chih-Yung%20Wen"> Chih-Yung Wen</a>, <a href="https://publications.waset.org/abstracts/search?q=Chiang-Ho%20Cheng"> Chiang-Ho Cheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu-Hsuan%20Juan">Yu-Hsuan Juan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of this study is to conduct computational fluid dynamic (CFD) simulations for evaluating the cooling efficacy from vegetation implanted in a public park in the Taipei, Taiwan. To probe the impacts of park renewal by means of adding three pavilions and supplementary green areas on urban microclimates, the simulated results have revealed that the park having a higher percentage of green coverage ratio (GCR) tended to experience a better cooling effect. These findings can be used to explore the effects of different greening modifications on urban environments for achieving an effective thermal comfort in urban public spaces. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CFD%20simulations" title="CFD simulations">CFD simulations</a>, <a href="https://publications.waset.org/abstracts/search?q=Green%20Coverage%20Ratio" title=" Green Coverage Ratio"> Green Coverage Ratio</a>, <a href="https://publications.waset.org/abstracts/search?q=Urban%20heat%20island" title=" Urban heat island"> Urban heat island</a>, <a href="https://publications.waset.org/abstracts/search?q=Urban%20Public%20Park" title=" Urban Public Park"> Urban Public Park</a> </p> <a href="https://publications.waset.org/abstracts/24561/cfd-simulations-to-study-the-cooling-effects-of-different-greening-modifications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24561.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">493</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">506</span> Biochemical and Electrochemical Characterization of Glycated Albumin: Clinical Relevance in Diabetes Associated Complications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alok%20Raghav">Alok Raghav</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamal%20Ahmad"> Jamal Ahmad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Serum albumin glycation and advanced glycation end products (AGE) formation correlates in diabetes and its associated complications. Extensive modified human serum albumin is used to study the biochemical, electrochemical and functional properties in hyperglycemic environment with relevance to diabetes. We evaluate Spectroscopic, side chain modifications, amino acid analysis, biochemical and functional group properties in four glucose modified samples. Methods: A series four human serum albumin samples modified with glucose was characterized in terms of amino acid analysis, spectroscopic properties and side chain modifications. The diagnostic technique employed incorporates UV Spectroscopy, Fluorescence Spectroscopy, biochemical assays for side chain modifications, amino acid estimations. Conclusion: Glucose modified human serum albumin confers AGE formation causes biochemical and functional property that depend on the reactivity of glucose and its concentration used for in-vitro glycation. A biochemical and functional characterization of modified albumin in-vitro produced AGE product that will be useful to interpret the complications and pathophysiological significance in diabetes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glycation" title="glycation">glycation</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes" title=" diabetes"> diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20serum%20albumin" title=" human serum albumin"> human serum albumin</a>, <a href="https://publications.waset.org/abstracts/search?q=biochemical%20and%20electrochemical%20characterization" title=" biochemical and electrochemical characterization"> biochemical and electrochemical characterization</a> </p> <a href="https://publications.waset.org/abstracts/14263/biochemical-and-electrochemical-characterization-of-glycated-albumin-clinical-relevance-in-diabetes-associated-complications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14263.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">374</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">505</span> Impact of Glycation on Proteomics of Human Serum Albumin: Relevance to Diabetes Associated Pathologies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alok%20Raghav">Alok Raghav</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamal%20Ahmad"> Jamal Ahmad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Serum albumin glycation and advanced glycation end products (AGE) formation correlates in diabetes and its associated complications. Extensive modified human serum albumin is used to study the biochemical, electrochemical and functional properties in hyperglycemic environment with relevance to diabetes. We evaluate Spectroscopic, side chain modifications, amino acid analysis, biochemical and functional group properties in four glucose modified samples. Methods: A series four human serum albumin samples modified with glucose was characterized in terms of amino acid analysis, spectroscopic properties and side chain modifications. The diagnostic technique employed incorporates UV Spectroscopy, Fluorescence Spectroscopy, biochemical assays for side chain modifications, amino acid estimations, electrochemical and optical characterstic of glycated albumin. Conclusion: Glucose modified human serum albumin confers AGEs formation alters biochemical, electrochemical, optical, and functional property that depend on the reactivity of glucose and its concentration used for in-vitro glycation. A biochemical, electrochemical, optical, and functional characterization of modified albumin in-vitro produced AGE product that will be useful to interpret the complications and pathophysiological significance in diabetes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20serum%20albumin" title="human serum albumin">human serum albumin</a>, <a href="https://publications.waset.org/abstracts/search?q=glycated%20albumin" title=" glycated albumin"> glycated albumin</a>, <a href="https://publications.waset.org/abstracts/search?q=adavanced%20glycation%20end%20products" title=" adavanced glycation end products"> adavanced glycation end products</a>, <a href="https://publications.waset.org/abstracts/search?q=associated%20pathologies" title=" associated pathologies"> associated pathologies</a> </p> <a href="https://publications.waset.org/abstracts/14588/impact-of-glycation-on-proteomics-of-human-serum-albumin-relevance-to-diabetes-associated-pathologies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14588.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">401</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">504</span> Global Convergence of a Modified Three-Term Conjugate Gradient Algorithms</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Belloufi%20Mohammed">Belloufi Mohammed</a>, <a href="https://publications.waset.org/abstracts/search?q=Sellami%20Badreddine"> Sellami Badreddine</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper deals with a new nonlinear modified three-term conjugate gradient algorithm for solving large-scale unstrained optimization problems. The search direction of the algorithms from this class has three terms and is computed as modifications of the classical conjugate gradient algorithms to satisfy both the descent and the conjugacy conditions. An example of three-term conjugate gradient algorithm from this class, as modifications of the classical and well known Hestenes and Stiefel or of the CG_DESCENT by Hager and Zhang conjugate gradient algorithms, satisfying both the descent and the conjugacy conditions is presented. Under mild conditions, we prove that the modified three-term conjugate gradient algorithm with Wolfe type line search is globally convergent. Preliminary numerical results show the proposed method is very promising. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=unconstrained%20optimization" title="unconstrained optimization">unconstrained optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=three-term%20conjugate%20gradient" title=" three-term conjugate gradient"> three-term conjugate gradient</a>, <a href="https://publications.waset.org/abstracts/search?q=sufficient%20descent%20property" title=" sufficient descent property"> sufficient descent property</a>, <a href="https://publications.waset.org/abstracts/search?q=line%20search" title=" line search"> line search</a> </p> <a href="https://publications.waset.org/abstracts/41727/global-convergence-of-a-modified-three-term-conjugate-gradient-algorithms" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41727.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">503</span> The Influence of Variable Geometrical Modifications of the Trailing Edge of Supercritical Airfoil on the Characteristics of Aerodynamics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20Lauk">P. Lauk</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20E.%20Seegel"> K. E. Seegel</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20T%C3%A4hemaa"> T. Tähemaa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The fuel consumption of modern, high wing loading, commercial aircraft in the first stage of flight is high because the usable flight level is lower and the weather conditions (jet stream) have great impact on aircraft performance. To reduce the fuel consumption, it is necessary to raise during first stage of flight the L/D ratio value within Cl 0.55-0.65. Different variable geometrical wing trailing edge modifications of SC(2)-410 airfoil were compared at M 0.78 using the CFD software STAR-CCM+ simulation based Reynolds-averaged Navier-Stokes (RANS) equations. The numerical results obtained show that by increasing the width of the airfoil by 4% and by modifying the trailing edge airfoil, it is possible to decrease airfoil drag at Cl 0.70 for up to 26.6% and at the same time to increase commercial aircraft L/D ratio for up to 5.0%. Fuel consumption can be reduced in proportion to the increase in L/D ratio. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=L%2FD%20ratio" title="L/D ratio">L/D ratio</a>, <a href="https://publications.waset.org/abstracts/search?q=miniflaps" title=" miniflaps"> miniflaps</a>, <a href="https://publications.waset.org/abstracts/search?q=mini-TED" title=" mini-TED"> mini-TED</a>, <a href="https://publications.waset.org/abstracts/search?q=supercritical%20airfoil" title=" supercritical airfoil"> supercritical airfoil</a> </p> <a href="https://publications.waset.org/abstracts/85202/the-influence-of-variable-geometrical-modifications-of-the-trailing-edge-of-supercritical-airfoil-on-the-characteristics-of-aerodynamics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85202.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">207</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">502</span> Effects of Continuous Training on Anthropometric Characteristics of Adolescents in Kano, Nigeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Emmanuel%20S.%20Adeyanju">Emmanuel S. Adeyanju</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study assessed the effects of continuous training on anthropometric characteristics of adolescents in Kano, Nigeria. The anthropometric measures of per cent body fat (%BF), body mass index (BMI), conicity index (CI) and waist-to-hip ratio (WHR) were selected because of their roles in increased adiposity and favourable cardiovascular disease (CVD) factor profiles in children and adolescence. The international standards and procedures were followed in all the measurements. A total of thirty (30) subjects (M=15; F=15), selected at random, were divided into two groups; one training (M=10; F=10) and the other control (M=5; F=5). Both groups were tested before training, at six (6) and 12 weeks in all the listed variables. The training group had 12 weeks continuous training which involved running round the standard 400 m track of the college following standard procedures; while the control group did not. The findings revealed significant sex-specific reductions in %BF (F=610.482 ˂ 0.05), BMI (F=73.860 ˂ 0.05), WHR (F=49.756 ˂ 0.05); however, no significant training effect on CI (F=1.855 ˃ 0.05) and WHR (F=1.956 ˃ 0.05) was found. Greater modifications found in females than in males (except in CI and WHR) due to training were probably related to their initial level of fitness and enzymatic modifications at subcellular level during training. The result also revealed significant relationship between the modifications in %BF, BMI and WHR but failed to establish any between CI and other adiposity measures. Thus, to avert the consequences of obesity and overweight, the declining fitness level of adolescents should be checked by ensuring they engaged in regular moderate-to-vigorous physical activity (MVPA) programmes. Such a childhood habit of exercise developed early in life will have a carry-over value into adult life and improve the quality of adult population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adiposity" title="adiposity">adiposity</a>, <a href="https://publications.waset.org/abstracts/search?q=anthropometry" title=" anthropometry"> anthropometry</a>, <a href="https://publications.waset.org/abstracts/search?q=conicity" title=" conicity"> conicity</a>, <a href="https://publications.waset.org/abstracts/search?q=continuous%20training" title=" continuous training"> continuous training</a> </p> <a href="https://publications.waset.org/abstracts/36126/effects-of-continuous-training-on-anthropometric-characteristics-of-adolescents-in-kano-nigeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/36126.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">501</span> A Bio-Inspired Approach to Produce Wettable Nylon Fabrics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sujani%20B.%20Y.%20Abeywardena">Sujani B. Y. Abeywardena</a>, <a href="https://publications.waset.org/abstracts/search?q=Srimala%20Perera"> Srimala Perera</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20M.%20Nalin%20De%20Silva"> K. M. Nalin De Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Walpalage"> S. Walpalage</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Surface modifications are vital to accomplish the moisture management property in highly demanded synthetic fabrics. Biomimetic and bio-inspired surface modifications are identified as one of the fascinating areas of research. In this study, nature’s way of cooling elephants’ body temperature using mud bathing was mimicked to create a superior wettable nylon fabric with improved comfortability. For that, bentonite nanoclay was covalently grafted on nylon fabric using silane as a coupling agent. Fourier transform infrared spectra and Scanning electron microscopy images confirmed the successful grafting of nanoclay on nylon. The superior wettability of surface modified nylon was proved by standard protocols. This fabric coating strongly withstands more than 50 cycles of laundry. It is expected that this bio-inspired wettable nylon fabric may break the barrier of using nylon in various hydrophilic textile applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bentonite%20nanoclay" title="bentonite nanoclay">bentonite nanoclay</a>, <a href="https://publications.waset.org/abstracts/search?q=biomimetic" title=" biomimetic"> biomimetic</a>, <a href="https://publications.waset.org/abstracts/search?q=covalent%20modification" title=" covalent modification"> covalent modification</a>, <a href="https://publications.waset.org/abstracts/search?q=nylon%20fabric" title=" nylon fabric"> nylon fabric</a>, <a href="https://publications.waset.org/abstracts/search?q=surface" title=" surface"> surface</a>, <a href="https://publications.waset.org/abstracts/search?q=wettability" title=" wettability"> wettability</a> </p> <a href="https://publications.waset.org/abstracts/77249/a-bio-inspired-approach-to-produce-wettable-nylon-fabrics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77249.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">201</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">500</span> Common Regulatory Mechanisms Reveals Links between Aberrant Glycosylation and Biological Hallmarks in Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jahanshah%20Ashkani">Jahanshah Ashkani</a>, <a href="https://publications.waset.org/abstracts/search?q=Kevin%20J.%20Naidoo"> Kevin J. Naidoo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Glycosylation is the major posttranslational modification (PTM) process in cellular development. In tumour development, it is marked by structural alteration of carbohydrates (glycans) that is the result of aberrant glycosylation. Altered glycan structures affect cell surface ligand-receptor interactions that interfere with the regulation of cell adhesion, migration, and proliferation. The resulting changes in glycan biosynthesis pathways originate from altered expression of glycosyltransferases and glycosidases. While the alteration in glycosylation patterns is a recognized “hallmark of cancer”, the influential overview of the biology of cancer proposes eight hallmarks with no explicit suggestion to connectivity with glycosylation. Recently, we have discovered a connection between the glycosyltransferase gene expression and cancer type and subtype. Here we present an association between aberrant glycosylation and the biological hallmarks of breast cancer by exploring the common regulatory mechanisms at the genomic scale. The result of this study bridges the glycobiological and biological pathways that are accepted hallmarks of cancer by connecting their common regulatory pathways. This is an impetus for further investigation as target therapies of breast cancer are very likely to be uncovered from this. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aberrant%20glycosylation" title="aberrant glycosylation">aberrant glycosylation</a>, <a href="https://publications.waset.org/abstracts/search?q=biological%20hallmarks" title=" biological hallmarks"> biological hallmarks</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=regulatory%20mechanism" title=" regulatory mechanism"> regulatory mechanism</a> </p> <a href="https://publications.waset.org/abstracts/53462/common-regulatory-mechanisms-reveals-links-between-aberrant-glycosylation-and-biological-hallmarks-in-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53462.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">255</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">499</span> A Hybrid Watermarking Model Based on Frequency of Occurrence</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hamza%20A.%20A.%20Al-Sewadi">Hamza A. A. Al-Sewadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Adnan%20H.%20M.%20Al-Helali"> Adnan H. M. Al-Helali</a>, <a href="https://publications.waset.org/abstracts/search?q=Samaa%20A.%20K.%20Khamis"> Samaa A. K. Khamis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ownership proofs of multimedia such as text, image, audio or video files can be achieved by the burial of watermark is them. It is achieved by introducing modifications into these files that are imperceptible to the human senses but easily recoverable by a computer program. These modifications would be in the time domain or frequency domain or both. This paper presents a procedure for watermarking by mixing amplitude modulation with frequency transformation histogram; namely a specific value is used to modulate the intensity component Y of the YIQ components of the carrier image. This scheme is referred to as histogram embedding technique (HET). Results comparison with those of other techniques such as discrete wavelet transform (DWT), discrete cosine transform (DCT) and singular value decomposition (SVD) have shown an enhance efficiency in terms of ease and performance. It has manifested a good degree of robustness against various environment effects such as resizing, rotation and different kinds of noise. This method would prove very useful technique for copyright protection and ownership judgment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=authentication" title="authentication">authentication</a>, <a href="https://publications.waset.org/abstracts/search?q=copyright%20protection" title=" copyright protection"> copyright protection</a>, <a href="https://publications.waset.org/abstracts/search?q=information%20hiding" title=" information hiding"> information hiding</a>, <a href="https://publications.waset.org/abstracts/search?q=ownership" title=" ownership"> ownership</a>, <a href="https://publications.waset.org/abstracts/search?q=watermarking" title=" watermarking"> watermarking</a> </p> <a href="https://publications.waset.org/abstracts/22392/a-hybrid-watermarking-model-based-on-frequency-of-occurrence" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22392.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">565</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">498</span> Frequency of Occurrence Hybrid Watermarking Scheme </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hamza%20A.%20Ali">Hamza A. Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Adnan%20H.%20M.%20Al-Helali"> Adnan H. M. Al-Helali</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Generally, a watermark is information that identifies the ownership of multimedia (text, image, audio or video files). It is achieved by introducing modifications into these files that are imperceptible to the human senses but easily recoverable by a computer program. These modifications are done according to a secret key in a descriptive model that would be either in the time domain or frequency domain or both. This paper presents a procedure for watermarking by mixing amplitude modulation with frequency transformation histogram; namely a specific value is used to modulate the intensity component Y of the YIQ components of the carrier image. This scheme is referred to as histogram embedding technique (HET). Results comparison with those of other techniques such as discrete wavelet transform (DWT), discrete cosine transform (DCT) and singular value decomposition (SVD) have shown an enhance efficiency in terms of ease and performance. It has manifested a good degree of robustness against various environment effects such as resizing, rotation and different kinds of noise. This method would prove very useful technique for copyright protection and ownership judgment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=watermarking" title="watermarking">watermarking</a>, <a href="https://publications.waset.org/abstracts/search?q=ownership" title=" ownership"> ownership</a>, <a href="https://publications.waset.org/abstracts/search?q=copyright%20protection" title=" copyright protection"> copyright protection</a>, <a href="https://publications.waset.org/abstracts/search?q=steganography" title=" steganography"> steganography</a>, <a href="https://publications.waset.org/abstracts/search?q=information%20hiding" title=" information hiding"> information hiding</a>, <a href="https://publications.waset.org/abstracts/search?q=authentication" title=" authentication"> authentication</a> </p> <a href="https://publications.waset.org/abstracts/20588/frequency-of-occurrence-hybrid-watermarking-scheme" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20588.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">368</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">497</span> Artificial Bee Colony Based Modified Energy Efficient Predictive Routing in MANET</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Akhil%20Dubey">Akhil Dubey</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajnesh%20Singh"> Rajnesh Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In modern days there occur many rapid modifications in field of ad hoc network. These modifications create many revolutionary changes in the routing. Predictive energy efficient routing is inspired on the bee’s behavior of swarm intelligence. Predictive routing improves the efficiency of routing in the energetic point of view. The main aim of this routing is the minimum energy consumption during communication and maximized intermediate node’s remaining battery power. This routing is based on food searching behavior of bees. There are two types of bees for the exploration phase the scout bees and for the evolution phase forager bees use by this routing. This routing algorithm computes the energy consumption, fitness ratio and goodness of the path. In this paper we review the literature related with predictive routing, presenting modified routing and simulation result of this algorithm comparison with artificial bee colony based routing schemes in MANET and see the results of path fitness and probability of fitness. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mobile%20ad%20hoc%20network" title="mobile ad hoc network">mobile ad hoc network</a>, <a href="https://publications.waset.org/abstracts/search?q=artificial%20bee%20colony" title=" artificial bee colony"> artificial bee colony</a>, <a href="https://publications.waset.org/abstracts/search?q=PEEBR" title=" PEEBR"> PEEBR</a>, <a href="https://publications.waset.org/abstracts/search?q=modified%20predictive%20routing" title=" modified predictive routing"> modified predictive routing</a> </p> <a href="https://publications.waset.org/abstracts/33480/artificial-bee-colony-based-modified-energy-efficient-predictive-routing-in-manet" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33480.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">417</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">496</span> Improvement of the Aerodynamic Behaviour of a Land Rover Discovery 4 in Turbulent Flow Using Computational Fluid Dynamics (CFD)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Al-Saadi">Ahmed Al-Saadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Hassanpour"> Ali Hassanpour</a>, <a href="https://publications.waset.org/abstracts/search?q=Tariq%20Mahmud"> Tariq Mahmud</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The main objective of this study is to investigate ways to reduce the aerodynamic drag coefficient and to increase the stability of the full-size Sport Utility Vehicle using three-dimensional Computational Fluid Dynamics (CFD) simulation. The baseline model in the simulation was the Land Rover Discovery 4. Many aerodynamic devices and external design modifications were used in this study. These reduction aerodynamic techniques were tested individually or in combination to get the best design. All new models have the same capacity and comfort of the baseline model. Uniform freestream velocity of the air at inlet ranging from 28 m/s to 40 m/s was used. ANSYS Fluent software (version 16.0) was used to simulate all models. The drag coefficient obtained from the ANSYS Fluent for the baseline model was validated with experimental data. It is found that the use of modern aerodynamic add-on devices and modifications has a significant effect in reducing the aerodynamic drag coefficient. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aerodynamics" title="aerodynamics">aerodynamics</a>, <a href="https://publications.waset.org/abstracts/search?q=RANS" title=" RANS"> RANS</a>, <a href="https://publications.waset.org/abstracts/search?q=sport%20utility%20vehicle" title=" sport utility vehicle"> sport utility vehicle</a>, <a href="https://publications.waset.org/abstracts/search?q=turbulent%20flow" title=" turbulent flow"> turbulent flow</a> </p> <a href="https://publications.waset.org/abstracts/63731/improvement-of-the-aerodynamic-behaviour-of-a-land-rover-discovery-4-in-turbulent-flow-using-computational-fluid-dynamics-cfd" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63731.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">495</span> Type 2 Diabetes Mellitus Among a St. Lucian Population: What We Know about Lifestyle Modification</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bradley%20Fevrier">Bradley Fevrier</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Type 2 diabetes mellitus, a non-communicable metabolic disorder, is a fast-growing problem for health, as it presents numerous complications and death worldwide. St. Lucia, much like most other emerging nation in the Caribbean, struggles with the management of type 2 diabetes mellitus (T2DM) among its populace. Good knowledge, attitude, and practices [KAP] of T2DM are essential in the prevention and management of this disease.Lifestyle adaptation, including increased knowledge, positive attitude, and efficient practice towards lifestyle modifications, can avert the advancement of difficulties associated with diabetes. Methods: An institutional-based cross-sectional study was conducted during the period June 15, 2022, to July15 2022. Data were collected by using the self-administered questionnaire designed to collect the required information from participants, and the data wasanalyzed using the statistical package for social science (SPSS) version 26. Knowledge, attitude, and practice of lifestyle modification among participants were determined using descriptive statistics. Results: A total of 402 participants completed the study, fully yielding an 84% response rate. Overall, the assessed levels of KAP relating to the life-threatening complications of T2DM were moderate. Results further indicated that women outnumbered men 68.4% to 31.6%, respectively. Significant positive correlation (r= 0.244, p<0.001) and (r=.203, p<0.001) were found between the knowledge level as well as the attitude level of study respondents. Conclusion: The overall study findings regarding the level of knowledge and attitude concerning lifestyle modifications among study participants were interpreted as generally high. However, the practice of healthy lifestyle modification habits was poor. The current findings suggest a need for structured educational campaigns prioritizing the importance of lifestyle modifications (weight loss, smoking cessation, physical exercise) to the general population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Diabetes" title="Diabetes">Diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=knowledge" title=" knowledge"> knowledge</a>, <a href="https://publications.waset.org/abstracts/search?q=lifestyle" title=" lifestyle"> lifestyle</a>, <a href="https://publications.waset.org/abstracts/search?q=survey" title=" survey"> survey</a> </p> <a href="https://publications.waset.org/abstracts/154650/type-2-diabetes-mellitus-among-a-st-lucian-population-what-we-know-about-lifestyle-modification" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154650.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">128</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">494</span> Influence of Pier Modification Techniques for Reducing Scour around Bridge Piers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rashid%20Farooq">Rashid Farooq</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdul%20Razzaq%20Ghumman"> Abdul Razzaq Ghumman</a>, <a href="https://publications.waset.org/abstracts/search?q=Hashim%20Nisar%20Hashmi"> Hashim Nisar Hashmi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bridge piers often fail all over the world and the whole structure may be endangered due to scouring phenomena. Scouring has been linked to catastrophic failures that lead into the loss of human lives. Various techniques have been employed to extenuate the scouring process in order to assist the bridge designs. Pier modifications plays vital role to control scouring at the vicinity of the pier. This experimental study aims at monitoring the effectiveness of pier modification and temporal development of scour depth around a bridge pier by providing a collar, a cable or openings under the same flow conditions. Provision of a collar around the octagonal pier reduced more scour depth than that for other two configurations. Providing a collar around the octagonal pier found to be the best in reducing scour. The scour depth in front of pier was found to be 19.5% less than that at the octagonal pier without any modifications. Similarly, the scour depth around the octagonal pier having provision of a cable was less than that at pier with provision of openings. The scour depth around an octagonal pier was also compared with a plain circular pier and found to be 9.1% less. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Scour" title="Scour">Scour</a>, <a href="https://publications.waset.org/abstracts/search?q=octagonal%20pier" title=" octagonal pier"> octagonal pier</a>, <a href="https://publications.waset.org/abstracts/search?q=collar" title=" collar"> collar</a>, <a href="https://publications.waset.org/abstracts/search?q=cable" title=" cable"> cable</a> </p> <a href="https://publications.waset.org/abstracts/56625/influence-of-pier-modification-techniques-for-reducing-scour-around-bridge-piers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56625.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">267</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">493</span> Neural Network Based Approach of Software Maintenance Prediction for Laboratory Information System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vuk%20M.%20Popovic">Vuk M. Popovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Dunja%20D.%20Popovic"> Dunja D. Popovic</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Software maintenance phase is started once a software project has been developed and delivered. After that, any modification to it corresponds to maintenance. Software maintenance involves modifications to keep a software project usable in a changed or a changing environment, to correct discovered faults, and modifications, and to improve performance or maintainability. Software maintenance and management of software maintenance are recognized as two most important and most expensive processes in a life of a software product. This research is basing the prediction of maintenance, on risks and time evaluation, and using them as data sets for working with neural networks. The aim of this paper is to provide support to project maintenance managers. They will be able to pass the issues planned for the next software-service-patch to the experts, for risk and working time evaluation, and afterward to put all data to neural networks in order to get software maintenance prediction. This process will lead to the more accurate prediction of the working hours needed for the software-service-patch, which will eventually lead to better planning of budget for the software maintenance projects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=laboratory%20information%20system" title="laboratory information system">laboratory information system</a>, <a href="https://publications.waset.org/abstracts/search?q=maintenance%20engineering" title=" maintenance engineering"> maintenance engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=neural%20networks" title=" neural networks"> neural networks</a>, <a href="https://publications.waset.org/abstracts/search?q=software%20maintenance" title=" software maintenance"> software maintenance</a>, <a href="https://publications.waset.org/abstracts/search?q=software%20maintenance%20costs" title=" software maintenance costs"> software maintenance costs</a> </p> <a href="https://publications.waset.org/abstracts/68789/neural-network-based-approach-of-software-maintenance-prediction-for-laboratory-information-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/68789.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">360</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">492</span> The Effect of Ambient Temperature on the Performance of the Simple and Modified Cycle Gas Turbine Plants</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ogbe%20E.%20E.">Ogbe E. E.</a>, <a href="https://publications.waset.org/abstracts/search?q=Ossia.%20C.%20V."> Ossia. C. V.</a>, <a href="https://publications.waset.org/abstracts/search?q=Saturday.%20E.%20G."> Saturday. E. G.</a>, <a href="https://publications.waset.org/abstracts/search?q=Ezekwe%20M.%20C."> Ezekwe M. C.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The disparity in power output between a simple and a modified gas turbine plant is noticeable when the gas turbine functions under local environmental conditions that deviate from the standard ISO specifications. Extensive research and literature have demonstrated a well-known direct correlation between ambient temperature and the power output of a gas turbine plant. In this study, the Omotosho gas turbine plant was modified into three different configurations. The reason for the modification is to improve its performance and reduce the fuel consumption and emission rate. Aspen Hysys software was used to simulate both the simple (Omotosho) and the three modified gas turbine plants. The input parameters considered include ambient temperature, air mass flow rate, fuel mass flow rate, water mass flow rate, turbine inlet temperature, compressor efficiency, and turbine efficiency, while the output parameters considered are thermal efficiency, specific fuel consumption, heat rate, emission rate, compressor power, turbine power and power output. The three modified gas turbine power plants incorporate an inlet air cooling system and a heat recovery steam generator. The variations between the modifications are due to additional components or enhancements alongside the inlet air cooling system and heat recovery steam generator incorporated; the first modification has an additional turbine, the second modification has an additional combustion chamber, and the third modification has an additional turbine and combustion chamber. This paper clearly shows ambient temperature effects on both the simple and three modified gas turbine plants. for every 10-degree kelvin increase in ambient temperature, there is an approximate reduction of 3977 kW, 4795 kW, 4681 kW, and 4793 kW of the power output for the simple gas turbine, first, second, and third modifications, respectively. Also, for every 10-degree kelvin increase in temperature, there is a thermal efficiency decrease of 1.22%, 1.45%, 1.43%, and 1.44% for the simple gas turbine, first, second, and third modifications respectively. Low ambient temperature will help save fuel; looking at the high price of fuel presently in Nigeria for every 10 degrees kelvin increase in temperature, there is a specific fuel consumption increase of 0.0074 kg/kWh, 0.0051 kg/kWh, 0.0061 kg/kWh, and 0.0057 kg/kWh for the simple gas turbine, first, second, and third modifications respectively. These findings will aid in accurately evaluating local power generating plants, particularly in hotter regions, for installing gas turbine inlet air cooling (GTIAC) systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aspen%20HYSYS%20software" title="Aspen HYSYS software">Aspen HYSYS software</a>, <a href="https://publications.waset.org/abstracts/search?q=Brayton%20Cycle" title=" Brayton Cycle"> Brayton Cycle</a>, <a href="https://publications.waset.org/abstracts/search?q=modified%20gas%20turbine" title=" modified gas turbine"> modified gas turbine</a>, <a href="https://publications.waset.org/abstracts/search?q=power%20plant" title=" power plant"> power plant</a>, <a href="https://publications.waset.org/abstracts/search?q=simple%20gas%20turbine" title=" simple gas turbine"> simple gas turbine</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20efficiency." title=" thermal efficiency."> thermal efficiency.</a> </p> <a href="https://publications.waset.org/abstracts/188879/the-effect-of-ambient-temperature-on-the-performance-of-the-simple-and-modified-cycle-gas-turbine-plants" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188879.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">35</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">491</span> PrEP and Risk: Challenges for an Emerging Sanitary Pact</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Roberto%20Rubem%20Silva-Brandao">Roberto Rubem Silva-Brandao</a>, <a href="https://publications.waset.org/abstracts/search?q=Aurea%20Maria%20Zollner%20Ianni"> Aurea Maria Zollner Ianni</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This article discusses the use and the incorporation of Pre-exposure Prophylaxis for HIV (PrEP) within a risk society context. Considering contemporary social theoreticians, we discuss implications of biotechnological uses for health enhancement. Firstly, we explore examples of biological manipulation and its consequences of use on given ecological dynamics, particularly taking into account other Sexually Transmitted Infections. In addition, we discuss how HIV resistance cases occurred with people on PrEP and its possible consequences on population-based interventions. Moreover, we present recent studies that analyze biological modifications on bodies of those who are on consistent use of PrEP, and how these body modifications are addressed on common practices of Public Health. Secondly, we present our theoretical references, which are intended to the analysis that situates our contemporary society in the reflexive stage of modernization. We discuss limits of biological use by individuals and how this can fabric feelings of freedom and autonomy within the individualization process and health. Finally, we argue that biotechnological uses on health, specifically on Public Health, tackling the risk aspects of its application, shows that another sanitary pact is needed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PrEP" title="PrEP">PrEP</a>, <a href="https://publications.waset.org/abstracts/search?q=public%20health" title=" public health"> public health</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20sciences" title=" social sciences"> social sciences</a>, <a href="https://publications.waset.org/abstracts/search?q=risk%20society" title=" risk society"> risk society</a> </p> <a href="https://publications.waset.org/abstracts/64792/prep-and-risk-challenges-for-an-emerging-sanitary-pact" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64792.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">393</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">490</span> On Dynamic Chaotic S-BOX Based Advanced Encryption Standard Algorithm for Image Encryption</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ajish%20Sreedharan">Ajish Sreedharan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Security in transmission and storage of digital images has its importance in today’s image communications and confidential video conferencing. Due to the increasing use of images in industrial process, it is essential to protect the confidential image data from unauthorized access. Advanced Encryption Standard (AES) is a well known block cipher that has several advantages in data encryption. However, it is not suitable for real-time applications. This paper presents modifications to the Advanced Encryption Standard to reflect a high level security and better image encryption. The modifications are done by adjusting the ShiftRow Transformation and using On Dynamic chaotic S-BOX. In AES the Substitute bytes, Shift row and Mix columns by themselves would provide no security because they do not use the key. In Dynamic chaotic S-BOX Based AES the Substitute bytes provide security because the S-Box is constructed from the key. Experimental results verify and prove that the proposed modification to image cryptosystem is highly secure from the cryptographic viewpoint. The results also prove that with a comparison to original AES encryption algorithm the modified algorithm gives better encryption results in terms of security against statistical attacks. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=advanced%20encryption%20standard%20%28AES%29" title="advanced encryption standard (AES)">advanced encryption standard (AES)</a>, <a href="https://publications.waset.org/abstracts/search?q=on%20dynamic%20chaotic%20S-BOX" title=" on dynamic chaotic S-BOX"> on dynamic chaotic S-BOX</a>, <a href="https://publications.waset.org/abstracts/search?q=image%20encryption" title=" image encryption"> image encryption</a>, <a href="https://publications.waset.org/abstracts/search?q=security%20analysis" title=" security analysis"> security analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=ShiftRow%20transformation" title=" ShiftRow transformation"> ShiftRow transformation</a> </p> <a href="https://publications.waset.org/abstracts/16549/on-dynamic-chaotic-s-box-based-advanced-encryption-standard-algorithm-for-image-encryption" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16549.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">437</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">489</span> Application of Modified Vermiculite for Cationic Textile Dyestuffs Removal: Sorption and Regeneration Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=W.%20Stawi%C5%84ski">W. Stawiński</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Wegrzyn"> A. Wegrzyn</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20M.%20Freitas"> O. M. Freitas</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20A.%20Figueiredo"> S. A. Figueiredo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Water is a life supporting resource, crucial for humanity and essential for natural ecosystems, which have been endangered by developing industry and increasing human population. Dyes are common in effluents discharged by various industries such as paper, plastics, food, cosmetics, and textile. They produce toxic effects on animals and disturb natural biological processes in receiving waters. Having complex molecular structure and resistance to biological decomposition they are problematic and difficult to be treated by conventional methods. In the search of efficient and sustainable method, sorption has been getting more interest in application to wastewaters treatment. Clays are minerals that have a layer structure based on phyllosilicate sheets that may carry a charge, which is balanced by ions located between the sheets. These charge-balancing ions can be exchanged resulting in very good ion-exchange properties of the material. Modifications of clays enhance their properties, producing a good and inexpensive sorbent for the removal of pollutants from wastewaters. The presented work proves that the treatment of a clay, vermiculite, with nitric acid followed by washing in citric acid strongly increases the sorption of two cationic dyes, methylene blue (C.I. 52015) and astrazon red (C.I. 110825). Desorption studies showed that the best eluent for regeneration is a solution of NaCl in ethanol. Cycles of sorption and desorption in column system showed no significant deterioration of sorption capacity and proved that the material shows a very good performance as sorbent, which can be recycled and reused. The results obtained open new possibilities of further modifications on vermiculite and modifications of other materials in order to get very efficient sorbents useful for wastewater treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cationic%20dyestuffs" title="cationic dyestuffs">cationic dyestuffs</a>, <a href="https://publications.waset.org/abstracts/search?q=sorption%20and%20regeneration" title=" sorption and regeneration"> sorption and regeneration</a>, <a href="https://publications.waset.org/abstracts/search?q=vermiculite" title=" vermiculite"> vermiculite</a>, <a href="https://publications.waset.org/abstracts/search?q=wastewater%20treatment" title=" wastewater treatment"> wastewater treatment</a> </p> <a href="https://publications.waset.org/abstracts/27639/application-of-modified-vermiculite-for-cationic-textile-dyestuffs-removal-sorption-and-regeneration-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27639.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">265</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">488</span> Parametric Study of the Structures: Influence of the Shells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Serikma%20Mourad">Serikma Mourad</a>, <a href="https://publications.waset.org/abstracts/search?q=Mezidi%20Amar"> Mezidi Amar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The conception (design) of an earthquake-resistant structure is a complex problem seen the necessity of meeting the requirements of security been imperative by the regulations, and of economy been imperative by the increasing costs of the structures. The resistance of a building in the horizontal actions (shares) is mainly ensured by a mixed brace system; for a concrete building, this system is constituted by frame or shells; or both at the same time. After the earthquake of Boumerdes (May 23; 2003) in Algeria, the studies made by experts, ended in modifications of the Algerian Earthquake-resistant Regulation (AER 99). One of these modifications was to widen the use of shells for the brace system. This modification has create a conflict on the quantities, the positions and the type of the shells at adopt. In the present project, we suggest seeing the effect of the variation of the dimensions, the localization and the conditions of rigidity in extremities of shells. The study will be led on a building (F+5) implanted in zone of seismicity average. To do it, we shall proceed to a classic dynamic study of a structure by using 4 alternatives for shells by varying the lengths and number in order to compare the cost of the structure for 4 dispositions of the shells with a technical-economic study of the brace system by the use of different dispositions of shells and to estimate the quantities of necessary materials (concrete and steel). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=reinforced%20concrete" title="reinforced concrete">reinforced concrete</a>, <a href="https://publications.waset.org/abstracts/search?q=mixed%20brace%20system" title=" mixed brace system"> mixed brace system</a>, <a href="https://publications.waset.org/abstracts/search?q=dynamic%20analysis" title=" dynamic analysis"> dynamic analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=beams" title=" beams"> beams</a>, <a href="https://publications.waset.org/abstracts/search?q=shells" title=" shells"> shells</a> </p> <a href="https://publications.waset.org/abstracts/44098/parametric-study-of-the-structures-influence-of-the-shells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/44098.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">325</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">487</span> Epigenetic Mechanisms Involved in the Occurrence and Development of Infectious Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Frank%20Boris%20Feutmba%20Keutchou">Frank Boris Feutmba Keutchou</a>, <a href="https://publications.waset.org/abstracts/search?q=Saurelle%20Fabienne%20Bieghan%20Same"> Saurelle Fabienne Bieghan Same</a>, <a href="https://publications.waset.org/abstracts/search?q=Verelle%20Elsa%20Fogang%20Pokam"> Verelle Elsa Fogang Pokam</a>, <a href="https://publications.waset.org/abstracts/search?q=Charles%20Ursula%20Metapi%20Meikeu"> Charles Ursula Metapi Meikeu</a>, <a href="https://publications.waset.org/abstracts/search?q=Angel%20Marilyne%20Messop%20Nzomo"> Angel Marilyne Messop Nzomo</a>, <a href="https://publications.waset.org/abstracts/search?q=Ousman%20Tamgue"> Ousman Tamgue</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Infectious diseases are one of the most important causes of morbidity and mortality worldwide. These diseases are caused by micro-pathogenic organisms, such as bacteria, viruses, parasites, and fungi. Heritable changes in gene expression that do not involve changes to the underlying DNA sequence are referred to as epigenetics. Emerging evidence suggests that epigenetic mechanisms are important in the emergence and progression of infectious diseases. Pathogens can manipulate host epigenetic machinery to promote their own replication and evade immune responses. The Human Genome Project has provided new opportunities for developing better tools for the diagnosis and identification of target genes. Several epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA expression, have been shown to influence infectious disease outcomes. Understanding the epigenetic mechanisms underlying infectious diseases may result in the progression of new therapeutic approaches focusing on host-pathogen interactions. The goal of this study is to show how different infectious agents interact with host cells after infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=epigenetic" title="epigenetic">epigenetic</a>, <a href="https://publications.waset.org/abstracts/search?q=infectious%20disease" title=" infectious disease"> infectious disease</a>, <a href="https://publications.waset.org/abstracts/search?q=micro-pathogenic%20organism" title=" micro-pathogenic organism"> micro-pathogenic organism</a>, <a href="https://publications.waset.org/abstracts/search?q=phenotype" title=" phenotype"> phenotype</a> </p> <a href="https://publications.waset.org/abstracts/164754/epigenetic-mechanisms-involved-in-the-occurrence-and-development-of-infectious-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/164754.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">81</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">486</span> Using Finite Element to Predict Failure of Light Weight Bridges Due to Vehicles Impact: Case Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amin%20H.%20Almasria">Amin H. Almasria</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajai%20Z.%20Alrousanb"> Rajai Z. Alrousanb</a>, <a href="https://publications.waset.org/abstracts/search?q=Al-Harith%20Manasrah"> Al-Harith Manasrah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The collapse of a light weight pedestrian bridges due to vehicle collision is investigated and studied in detail using a dynamic nonlinear finite element analysis. Typical bridge widely used in Jordan is studied and modeled under truck collision using one dimensional beam finite element in order to minimize analysis time due to the dynamic nature of the problem. Truck collision with the bridge is simulated at different speeds and locations of collisions using dynamic explicit finite element scheme with material nonlinearity taken into account. Energy absorption of bridge is investigated through principle of energy conservation, where truck kinetic energy is assumed to be stored in the bridge as strain energy. Weak failure points in the bridges were identified, and modifications are proposed in order to strengthen the bridge structure and prevent total collapse. The proposed design modifications on bridge structure were successful in allowing the bridge to fail locally rather than globally and expected to help in saving lives. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=finite%20element%20method" title="finite element method">finite element method</a>, <a href="https://publications.waset.org/abstracts/search?q=dynamic%20impact" title=" dynamic impact"> dynamic impact</a>, <a href="https://publications.waset.org/abstracts/search?q=pedestrian%20bridges" title=" pedestrian bridges"> pedestrian bridges</a>, <a href="https://publications.waset.org/abstracts/search?q=strain%20energy" title=" strain energy"> strain energy</a>, <a href="https://publications.waset.org/abstracts/search?q=collapse%20failure" title=" collapse failure"> collapse failure</a> </p> <a href="https://publications.waset.org/abstracts/20714/using-finite-element-to-predict-failure-of-light-weight-bridges-due-to-vehicles-impact-case-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20714.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">624</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">485</span> Production of Insulin Analogue SCI-57 by Transient Expression in Nicotiana benthamiana</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adriana%20Mu%C3%B1oz-Talavera">Adriana Muñoz-Talavera</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Rosa%20Rinc%C3%B3n-S%C3%A1nchez"> Ana Rosa Rincón-Sánchez</a>, <a href="https://publications.waset.org/abstracts/search?q=Abraham%20Escobedo-Moratilla"> Abraham Escobedo-Moratilla</a>, <a href="https://publications.waset.org/abstracts/search?q=Mar%C3%ADa%20Cristina%20Islas-Carbajal"> María Cristina Islas-Carbajal</a>, <a href="https://publications.waset.org/abstracts/search?q=Miguel%20%C3%81ngel%20G%C3%B3mez-Lim"> Miguel Ángel Gómez-Lim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The highest rates of diabetes incidence and prevalence worldwide will increase the number of diabetic patients requiring insulin or insulin analogues. Then, current production systems would not be sufficient to meet the future market demands. Therefore, developing efficient expression systems for insulin and insulin analogues are needed. In addition, insulin analogues with better pharmacokinetics and pharmacodynamics properties and without mitogenic potential will be required. SCI-57 (single chain insulin-57) is an insulin analogue having 10 times greater affinity to the insulin receptor, higher resistance to thermal degradation than insulin, native mitogenicity and biological effect. Plants as expression platforms have been used to produce recombinant proteins because of their advantages such as cost-effectiveness, posttranslational modifications, absence of human pathogens and high quality. Immunoglobulin production with a yield of 50% has been achieved by transient expression in Nicotiana benthamiana (Nb). The aim of this study is to produce SCI-57 by transient expression in Nb. Methodology: DNA sequence encoding SCI-57 was cloned in pICH31070. This construction was introduced into Agrobacterium tumefaciens by electroporation. The resulting strain was used to infiltrate leaves of Nb. In order to isolate SCI-57, leaves from transformed plants were incubated 3 hours with the extraction buffer therefore filtrated to remove solid material. The resultant protein solution was subjected to anion exchange chromatography on an FPLC system and ultrafiltration to purify SCI-57. Detection of SCI-57 was made by electrophoresis pattern (SDS-PAGE). Protein band was digested with trypsin and the peptides were analyzed by Liquid chromatography tandem-mass spectrometry (LC-MS/MS). A purified protein sample (20µM) was analyzed by ESI-Q-TOF-MS to obtain the ionization pattern and the exact molecular weight determination. Chromatography pattern and impurities detection were performed using RP-HPLC using recombinant insulin as standard. The identity of the SCI-57 was confirmed by anti-insulin ELISA. The total soluble protein concentration was quantified by Bradford assay. Results: The expression cassette was verified by restriction mapping (5393 bp fragment). The SDS-PAGE of crude leaf extract (CLE) of transformed plants, revealed a protein of about 6.4 kDa, non-present in CLE of untransformed plants. The LC-MS/MS results displayed one peptide with a high score that matches SCI-57 amino acid sequence in the sample, confirming the identity of SCI-57. From the purified SCI-57 sample (PSCI-57) the most intense charge state was 1069 m/z (+6) on the displayed ionization pattern corresponding to the molecular weight of SCI-57 (6412.6554 Da). The RP-HPLC of the PSCI-57 shows the presence of a peak with similar retention time (rt) and UV spectroscopic profile to the insulin standard (SCI-57 rt=12.96 and insulin rt=12.70 min). The collected SCI-57 peak had ELISA signal. The total protein amount in CLE from transformed plants was higher compared to untransformed plants. Conclusions: Our results suggest the feasibility to produce insulin analogue SCI-57 by transient expression in Nicotiana benthamiana. Further work is being undertaken to evaluate the biological activity by glucose uptake by insulin-sensitive and insulin-resistant murine and human cultured adipocytes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=insulin%20analogue" title="insulin analogue">insulin analogue</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20spectrometry" title=" mass spectrometry"> mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=Nicotiana%20benthamiana" title=" Nicotiana benthamiana"> Nicotiana benthamiana</a>, <a href="https://publications.waset.org/abstracts/search?q=transient%20expression" title=" transient expression"> transient expression</a> </p> <a href="https://publications.waset.org/abstracts/69283/production-of-insulin-analogue-sci-57-by-transient-expression-in-nicotiana-benthamiana" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69283.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">351</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=post-translational%20modifications&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=post-translational%20modifications&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=post-translational%20modifications&page=4">4</a></li> <li class="page-item"><a class="page-link" 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