TGF-beta Pan Specific Antibody AB-100-NA: R&D Systems

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class="ds_title">TGF-beta Pan Specific Antibody </h1> <div class="dsSprite_rnd ds_brand_logo ds_rnd_logo"></div> </div> <div class="product_meta"> <span class="category_number">Catalog #: AB-100-NA</span> <br/> <span class="citations"> <a href="#product-citations" id="citation_count" class="jump_to" data-tab="3" data-tabname="product-citations"> 91 Citations </a> </span> <span class="reviews review_stars_4"> <a href="#product-reviews" id="product_reviews" class="jump_to" data-tab="6" data-tabname="product-reviews"> 3 Reviews </a> </span> <a href="/reviews/AB-100-NA" rel="nofollow"><span class="submit_review"><button class="btn btn-quaternary">Submit a Review</button></span></a> <span class="datasheet_link"> <a href="#product-datasheets">Datasheet / COA / SDS</a> </span> </div>  <div class="product_wrapper row"> <div class="product_ordering_wrapper col-xs-12 col-md-8 col-md-push-4"> <div class="product_ordering"> <form action="/products/tgf-beta-pan-specific-antibody_ab-100-na" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block">     <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th class="ds_availability_column mobile-hide">Availability</th> <th class="ds_size_price_column">Size / Price</th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="AB-100-NA"> <td class="dat_catalog_column">AB-100-NA</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-ab-100-na form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-ab-100-na" name="catnum-AB-100-NA" value="" size="5" maxlength="3" /></div></td> </tr> </tbody> </table> <div class="ds_atc_pre_buttons"></div> <div class="ds_atc_buttons"> <a href="/quote/instruments/ella-automated-immunoassay-system" class="btn btn-secondary atc_request_quote_simple_plex_assay" style="display:none" rel="nofollow">Request a Quote</a> <a href="/services/bulk-quote-request?catnum=AB-100-NA&product=TGF-beta Pan Specific Antibody" class="btn btn-secondary atc_hidden bulk_btn" style="display:none;" rel="nofollow" title="Competitive discounts on products purchased in bulk quantities">Bulk Orders</a> <button class="btn btn-primary atc_hidden atc_btn form-submit icon-before" style="display:none;" title="Enter quantities above and click to add to cart" type="submit" id="edit-add-to-cart" name="add_to_cart_btn" value="Add to Cart"><span class="icon glyphicon glyphicon-plus" aria-hidden="true"></span> Add to Cart</button> </div> <div class="ds_atc_post_buttons"></div> </div> <input type="hidden" name="form_build_id" value="form-o7j6_L2R0Dwn6rC9HiER3RPSfSAR6AWMt0OuIydkuwk" /> <input type="hidden" name="form_id" value="atc_datasheet_form" /> </div></form> </div> </div> <div class="product_image_wrapper col-xs-12 col-md-4 col-md-pull-8"> <div class="product_image"> <span class="product_image_label"> </span> <a class="ds-image overview-images" data-toggle="lightbox" data-gallery="overview-images" onClick="event.preventDefault();" data-title="TGF-beta Pan Specific in Human Prostate Tissue." data-footer="TGF-beta Pan Specific in Human Prostate Tissue." title="Cat. No. AB-100-NA - TGF-beta Pan&#160;Specific Antibody" href="https://resources.rndsystems.com/images/datasheets/antibody/TGFbeta_AB100NA_Immunohistochemistry_24182.jpg"> <img fetchpriority="high" src="https://resources.rndsystems.com/images/datasheets/antibody/TGFbeta_AB100NA_Immunohistochemistry_24182.jpg" class="img-fluid" alt="TGF-beta Pan Specific in Human Prostate Tissue." title="TGF-beta Pan Specific in Human Prostate Tissue."> </a> <div class="search_image_other_count"> <span class="search_more_images">4 Images</span> </div> </div> </div> <div id="extra_images overview-images" class="hidden"> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody." data-title="TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody." title="Cat. No. AB-100-NA - TGF-beta Pan&#160;Specific Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/antibody/TGF-beta_5_AB-100-NA_Block_Neutralize_8555.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/antibody/TGF-beta_5_AB-100-NA_Block_Neutralize_8555.jpg" class="img-fluid" loading="lazy" alt="TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody." title="TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody."> </a> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Human TGF-beta by Flow Cytometry" data-title="Detection of Human TGF-beta by Flow Cytometry" title="Cat. No. AB-100-NA - TGF-beta Pan&#160;Specific Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/ab-100-na_tgf-beta-pan-specific-polyclonal-ab-8220249503250.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/ab-100-na_tgf-beta-pan-specific-polyclonal-ab-8220249503250.jpg" class="img-fluid" loading="lazy" alt="Detection of Human TGF-beta by Flow Cytometry" title="Detection of Human TGF-beta by Flow Cytometry"> </a> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Human TGF-beta by Flow Cytometry" data-title="Detection of Human TGF-beta by Flow Cytometry" title="Cat. No. AB-100-NA - TGF-beta Pan&#160;Specific Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/ab-100-na_tgf-beta-pan-specific-polyclonal-ab-44202415425012.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/ab-100-na_tgf-beta-pan-specific-polyclonal-ab-44202415425012.jpg" class="img-fluid" loading="lazy" alt="Detection of Human TGF-beta by Flow Cytometry" title="Detection of Human TGF-beta by Flow Cytometry"> </a> </div> </div> <div class="product_info_wrapper"> </div> <div id="view-more-target" class="datasheet_section_element"> <a href="/target/tgf-beta?category=Primary Antibodies" class="btn btn-secondary">All TGF-beta Antibodies</a> </div> </div> <div class="tabbed_content" id="rnd_antibody"> <div id="ds_tabs" class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details" id="dsTabs_product-details"> <span>Product Details</span> </div> <div class="tab tab_3" data-tab="3" data-tabname="product-citations" id="dsTabs_product-citations"> <span>Citations (91)</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="faqs" id="dsTabs_faqs"> <span>FAQs</span> </div> <div class="tab tab_5" data-tab="5" data-tabname="supplemental-products" id="dsTabs_supplemental-products"> <span>Supplemental Products</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="product-reviews" id="dsTabs_product-reviews"> <span> Reviews (3) </span> </div> </div> <div class="tab_content tab_1 tab_open" data-tab="1" data-tabname="product-details" id="product-details"> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_summary" id="product-anchor-ds_summary">Summary</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_data_examples" id="product-anchor-ds_data_examples">Data Examples</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_preparation_storage" id="product-anchor-ds_preparation_storage">Preparation and Storage</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_calculator" id="product-anchor-ds_calculator">Reconstitution Calculator</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_background" id="product-anchor-ds_background">Background</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_datasheets" id="product-anchor-ds_datasheets">Product Datasheets</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_related_research_areas" id="product-anchor-ds_related_research_areas">Related Research Areas</a> </div> <h2 id="ds_summary">TGF-beta Pan Specific Antibody Summary</h2> <div class="datasheet_section"> <div class="ds_table summary_table"> <div class="ds_table_body">  <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Specificity</div> <div class="ds_table_cell summary_table_data"> Detects TGF-beta 1, TGF-beta 1.2, TGF-beta 2, TGF-beta 3, and TGF-beta 5 in direct ELISAs and Western blots. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Source</div> <div class="ds_table_cell summary_table_data"> Polyclonal Rabbit IgG </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Purification</div> <div class="ds_table_cell summary_table_data"> Protein A or G purified </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Immunogen</div> <div class="ds_table_cell summary_table_data"> Recombinant human TGF‑ beta 1, porcine platelet-derived TGF‑ beta 1.2, porcine platelet-derived TGF‑ beta 2, and recombinant amphibian TGF‑ beta 5 </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Formulation</div> <div class="ds_table_cell summary_table_data"> Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Endotoxin Level</div> <div class="ds_table_cell summary_table_data"> <0.10 EU per 1 μg of the antibody by the LAL method. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Label</div> <div class="ds_table_cell summary_table_data"> Unconjugated </div> </div> </div> </div> </div> <div id="customer_also_purchased_block" class="loader" data-catalogId="AB-100-NA"></div> <div id="ds_applications" class="datasheet_section"> <h2>Applications</h2> <div class="ds_table app_table"> <div class="ds_table_head"> <div class="ds_table_head_row"> <div class="ds_table_head_cell app_table_blank"></div> <div class="ds_table_head_cell app_table_rec_conc">Recommended Concentration</div> <div class="ds_table_head_cell app_table_sample">Sample</div> </div> </div> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell app_table_name">Western Blot</div> <div class="ds_table_cell app_table_dilution">1 µg/mL</div> <div class="ds_table_cell app_table_sample">Recombinant Human TGF-beta 1 (Catalog # <A class="NoLineLink" href="http://www.rndsystems.com/search?keywords=240-B">240-B</a>) <BR/>Recombinant Human TGF-beta 2 (Catalog # <A class="NoLineLink" href="http://www.rndsystems.com/search?keywords=302-B2">302-B2</a>) <BR/>Recombinant Human TGF-beta 1.2 (Catalog # <A class="NoLineLink" href="http://www.rndsystems.com/search?keywords=304-B3">304-B3</a>) <BR/>Recombinant Human TGF-beta 3 (Catalog # <A class="NoLineLink" href="http://www.rndsystems.com/search?keywords=243-B3">243-B3</a>) <BR/>Recombinant Amphibian TGF-beta 5 (Catalog # <A class="NoLineLink" href="http://www.rndsystems.com/search?keywords=245-B5">245-B5</a>) <BR/>under non-reducing conditions only</div> </div> <div class="ds_table_row"> <div class="ds_table_cell app_table_name ich_cell">Immunohistochemistry</div> <div class="ds_table_cell app_table_dilution">3-15 µg/mL</div> <div class="ds_table_cell app_table_sample">See below</div> </div> </div> </div> <div class="ds_table summary_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Neutralization</div> <div class="ds_table_cell summary_table_data">Measured by its ability to neutralize TGF‑ beta 1 inhibition of IL‑4-dependent proliferation in the HT‑2 mouse T cell line. Tsang, M. <EM>et al</EM>. (1995) Cytokine <STRONG>7</STRONG>:389. The Neutralization Dose (ND<SUB>50</SUB>) is approximately  1 µg/mL, 15 µg/mL, 4 µg/mL, and 1 µg/mL for Porcine TGF-beta 1.2, Porcine TGF-beta 2, Recombinant Chicken TGF-beta 3, and Recombinant Amphibian TGF-beta 5, respectively. The ND<SUB>50</SUB> range for Porcine TGF-beta 1 is 5-30 µg/mL.</div> </div> </div> </div> <p>Please Note: Optimal dilutions should be determined by each laboratory for each application. <a href="/resources/protocols-troubleshooting-guides">General Protocols</a> are available in the Technical Information section on our website. </p> </div> <div id="ds_scientific_data" class="datasheet_section"> <div id="ds_data_examples"> <h2>Scientific Data</h2> <div id="data_examples"> <div class="row data_ex_row"> <a id="ds_image_0" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Immunohistochemistry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-0" data-title="TGF-beta Pan Specific in Human Prostate Tissue." data-footer="TGF-beta Pan Specific antibody in Human Prostate Tissue by Immunohistochemistry (IHC-P)." title="Cat. No. AB-100-NA - TGF-beta Pan Specific antibody in Human Prostate Tissue by Immunohistochemistry (IHC-P)." href="https://resources.rndsystems.com/images/datasheets/antibody/TGFbeta_AB100NA_Immunohistochemistry_24182.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/antibody/TGFbeta_AB100NA_Immunohistochemistry_24182.jpg" class="img-fluid" alt="TGF-beta Pan Specific antibody in Human Prostate Tissue by Immunohistochemistry (IHC-P)." title="TGF-beta Pan Specific antibody in Human Prostate Tissue by Immunohistochemistry (IHC-P)."> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">TGF-beta Pan Specific in Human Prostate Tissue.</span> TGF-beta was detected in immersion fixed paraffin-embedded sections of human prostate tissue using Rabbit Anti-TGF-beta Pan Specific Polyclonal Antibody (Catalog # AB-100-NA) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/rabbit-igg-visucyte-hrp-polymer-antibody_vc003">VC003</a>). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/antigen-retrieval-reagent-basic_cts013">CTS013</a>). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in epitjhelial cells. View our protocol for <a class="NoLineLink" href="https://www.rndsystems.com/resources/protocols/protocol-visucyte-hrp-polymer-detection-reagent">IHC Staining with VisUCyte HRP Polymer Detection Reagents</a>. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_1" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Neutralization </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-1" data-title="TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody." data-footer="TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody." title="Cat. No. AB-100-NA - TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody." href="https://resources.rndsystems.com/images/datasheets/antibody/TGF-beta_5_AB-100-NA_Block_Neutralize_8555.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/antibody/TGF-beta_5_AB-100-NA_Block_Neutralize_8555.jpg" class="img-fluid" alt="TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody." title="TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody."> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta Antibody.</span> Porcine TGF-beta 1 (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/porcine-tgf-beta-1-protein_101-b1">101-B1</a>) inhibits Recombinant Mouse IL-4 (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/recombinant-mouse-il-4-protein_404-ml">404-ML</a>) induced proliferation in the HT-2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL-4 (7.5 ng/mL) activity elicited by Porcine TGF-beta 1 (1 ng/mL) is neutralized (green line) by increasing concentrations of TGF-beta Pan Specific Polyclonal Antibody (Catalog # AB-100-NA). The ND<sub>50</sub>range is 5-30 µg/mL. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_2" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Flow Cytometry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-2" data-title="Detection of Human TGF-beta by Flow Cytometry" data-footer="Detection of Human TGF-beta by Flow Cytometry" title="Cat. No. AB-100-NA - Detection of Human TGF-beta by Flow Cytometry" href="https://resources.rndsystems.com/images/datasheets/ab-100-na_tgf-beta-pan-specific-polyclonal-ab-8220249503250.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/ab-100-na_tgf-beta-pan-specific-polyclonal-ab-8220249503250.jpg" class="img-fluid" alt="Detection of Human TGF-beta by Flow Cytometry" title="Detection of Human TGF-beta by Flow Cytometry"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Human TGF-beta by Flow Cytometry</span> TGF-beta induces IL-9 mRNA expression in Th1 and Th2 cells.Naïve CD4+ T cells were activated with fibroblast-bound anti-CD3/CD28 under classical Th1 and Th2 conditions, with IL-12 and anti-IL-4 or IL-4, anti-IFN-gamma, and anti-IL-12 respectively for 5 days, restimulated at day 5 and split in cultures with and without TGF-beta or anti-TGF-beta for 5 more days of stimulation. (A, C and D) qRT-PCR gene expression analysis of the relative gene expression of IL-9, GATA3, and Tbet at day 10 relative to the Th0 culture. (B) CT value from qRT-PCR gene expression analysis of the gene PU.1. Each donor is represented by a specific symbol and connected with a line. Data are from four independent experiments, each with two donors. *p<0.05, **p<0.01, ***p<0.001. Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0021695), licensed under a CC-BY license. Not internally tested by R&D Systems. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_3" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Flow Cytometry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-3" data-title="Detection of Human TGF-beta by Flow Cytometry" data-footer="Detection of Human TGF-beta by Flow Cytometry" title="Cat. No. AB-100-NA - Detection of Human TGF-beta by Flow Cytometry" href="https://resources.rndsystems.com/images/datasheets/ab-100-na_tgf-beta-pan-specific-polyclonal-ab-44202415425012.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/ab-100-na_tgf-beta-pan-specific-polyclonal-ab-44202415425012.jpg" class="img-fluid" alt="Detection of Human TGF-beta by Flow Cytometry" title="Detection of Human TGF-beta by Flow Cytometry"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Human TGF-beta by Flow Cytometry</span> TGF-beta induces IL-9 mRNA expression in Th1 and Th2 cells.Naïve CD4+ T cells were activated with fibroblast-bound anti-CD3/CD28 under classical Th1 and Th2 conditions, with IL-12 and anti-IL-4 or IL-4, anti-IFN-gamma, and anti-IL-12 respectively for 5 days, restimulated at day 5 and split in cultures with and without TGF-beta or anti-TGF-beta for 5 more days of stimulation. (A, C and D) qRT-PCR gene expression analysis of the relative gene expression of IL-9, GATA3, and Tbet at day 10 relative to the Th0 culture. (B) CT value from qRT-PCR gene expression analysis of the gene PU.1. Each donor is represented by a specific symbol and connected with a line. Data are from four independent experiments, each with two donors. *p<0.05, **p<0.01, ***p<0.001. Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0021695), licensed under a CC-BY license. Not internally tested by R&D Systems. </p> </div> </div> </div> </div> </div> <div id="ds_calculator" class="datasheet_section"> <div id="btn_calculator_wrapper"><div class="datasheet_calculator_toggle btn btn-secondary" id="btn_reconstitution">Reconstitution Calculator</div></div><div id="datasheet_calculators"><div id="btn_reconstitution_calc" class="datasheet_calculator"><h2>Reconstitution Calculator</h2><div id="reconstitution_calculator" class="calculator"> <form id="recCalc"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume (to add to vial)</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass (in vial)</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </span> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Desired Reconstitution Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </span> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> </div></div> </div> <div id="ds_preparation_storage" class="datasheet_section"> <h2>Preparation and Storage</h2> <div class="ds_table prep_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Reconstitution</div> <div class="ds_table_cell prep_table_data">Reconstitute at 1 mg/mL in sterile PBS. <div id="reconstitution-buffer"> <div id="reconstitution-buffer-placeholder"> <div class="et_spinner_small"></div> Loading... </div> </div> </div> </div> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Shipping</div> <div class="ds_table_cell prep_table_data">The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Stability & Storage</div> <div class="ds_table_cell prep_table_data"><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>12 months from date of receipt, -20 to -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>6 months, -20 to -70 °C under sterile conditions after reconstitution.</LI></UL> </div> </div> </div> </div> </div> <div id="ds_background" class="datasheet_section"> <h2>Background: TGF-beta</h2> <p><p>TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure. TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-beta isoform has some non-redundant functions; for TGF-beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation. Human TGF-beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein. A furin-like convertase processes the proprotein to generate an N-terminal 249 aa latency-associated peptide (LAP) and a C-terminal 112 aa mature TGF- beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain non-covalently associated after secretion, forming the small latent TGF-beta 1 complex. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix. TGF-beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins. Mature human TGF-beta 1 shares 100% aa identity with pig, dog and cow TGF-beta 1, and 99% aa identity with mouse, rat and horse TGF-beta 1. It demonstrates cross-species activity. TGF-beta 1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-beta RI (also called activin receptor-like kinase (ALK) -5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription. Contributions of the accessory receptors betaglycan (also known as TGF-beta RIII) and endoglin, or use of Smad-independent signaling pathways, allow for disparate actions observed in response to TGF-beta in different contexts.</p></p> <div class="ds_table background_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Long Name</div> <div class="ds_table_cell background_table_data">Transforming Growth Factor beta</div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Alternate Names</div> <div class="ds_table_cell background_table_data">CED; DPD1; LAP; TGFB; TGFB1; TGFbeta; TGF-beta; transforming growth factor beta 1</div> </div> </div> </div> </div> <div class="datasheet_section" id="product-datasheets"> <h2 id="ds_datasheets">Product Datasheets</h2> <div class="product_datasheets"> <span class="sds-message hide"> <p class="sds-label">You must select a language.</p> <span class="close_sds_message">x</span> </span> <div class="ds_document"> <a id="cfpdf" href="//resources.rndsystems.com/pdfs/datasheets/ab-100-na.pdf?v=20241126" class="datasheets-link " target="_blank" rel="noreferrer nofollow">Product Datasheet</a> </div> <div class="ds_document"> <div class="ds_pdfData"><a class="datasheets-link" href="https://www.rndsystems.com/cofas/tgf-beta-pan-specific-antibody_ab-100-na">COA</a> </div> </div> <div class="ds_document sds_link"> <a class="sds_non_cf datasheets-link non_cf_download_link" target="_blank" rel="noreferrer" data-path="//aero.bio-techne.com/sds/pdf/ab-100-na?v=20241126">SDS</a> </div> </div> </div> <div id="ds_related_research_areas" class="datasheet_section"> <h2>Related Research Areas</h2> <ul class="ds_details"> <li> <a href="/research-area/airway-inflammation-and-remodeling">Airway Inflammation and Remodeling</a> </li> <li> <a href="/research-area/alpha-granule-soluble-molecules">Alpha Granule Soluble Molecules</a> </li> <li> <a href="/research-area/b-cell-markers">B Cell Markers</a> </li> <li> <a href="/research-area/cytokines-and-receptors-in-angiogenesis">Cytokines and Receptors in Angiogenesis</a> </li> <li> <a href="/research-area/early-mesodermal-lineage-markers">Early Mesodermal Lineage Markers</a> </li> <li> <a href="/research-area/gamma-delta-t-cells">gamma delta T Cells</a> </li> <li> <a href="/research-area/macrophage-activation-markers">Macrophage Activation Markers</a> </li> <li> <a href="/research-area/multiple-sclerosis-and-myelin-related-molecules">Multiple Sclerosis and Myelin Related Molecules</a> </li> <li> <a href="/research-area/myeloid--derived-suppressor-cells--mdsc">Myeloid-derived Suppressor Cells (MDSC)</a> </li> <li> <a href="/research-area/t-cell-cytokine-signaling">T Cell Cytokine Signaling</a> </li> <li> <a href="/research-area/tgf--beta-family">TGF-beta Family</a> </li> <li> <a href="/research-area/tgf--beta-family-ligands">TGF-beta Family Ligands</a> </li> <li> <a href="/research-area/th17-cells">Th17 Cells</a> </li> <li> <a href="/research-area/th22-cells">Th22 Cells</a> </li> <li> <a href="/research-area/th9-cells">Th9 Cells</a> </li> </ul> </div> </div> <div class="tab_content tab_3" data-tab="3" data-tabname="product-citations" id="citations"> <a id="citations_section"></a> <h2><span class="citations">Citations for TGF-beta Pan Specific Antibody</h2> <div id="citation"> <a id="dsTabCitations"></a> <p> R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. </p> <p> <strong><span id="maxcitations">91</span> Citations: Showing <span id="showfrom">1</span> - <span id="showto">10</span> </strong> <br/><strong>Filter your results:</strong> </p> <div class="row"> <div class="col-sm-12"> <div class="citations_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper filter_select"> <select id="selSpecies" title="Species"> <option value="All">All Species</option> <option class="citation_filterRadio" value="species" data-filter="Bovine"> Bovine </option> <option class="citation_filterRadio" value="species" data-filter="Goat"> Goat </option> <option class="citation_filterRadio" value="species" data-filter="Human"> Human </option> <option class="citation_filterRadio" value="species" data-filter="Mink"> Mink </option> <option class="citation_filterRadio" value="species" data-filter="Mouse"> Mouse </option> <option class="citation_filterRadio" value="species" data-filter="Primate - Macaca mulatta (Rhesus Macaque)"> Primate - Macaca mulatta (Rhesus Macaque) </option> <option class="citation_filterRadio" value="species" data-filter="Rat"> Rat </option> </select> </div> <div class="select_wrapper filter_select"> <select id="selAntibody" title="Applications"> <option value="All">All Applications</option> <option class="citation_filterRadio" value="application" data-filter="Bioassay"> Bioassay </option> <option class="citation_filterRadio" value="application" data-filter="Blocking"> Blocking </option> <option class="citation_filterRadio" value="application" data-filter="Cell Culture"> Cell Culture </option> <option class="citation_filterRadio" value="application" data-filter="Electron Microscopy"> Electron Microscopy </option> <option class="citation_filterRadio" value="application" data-filter="ICC"> ICC </option> <option class="citation_filterRadio" value="application" data-filter="IHC"> IHC </option> <option class="citation_filterRadio" value="application" data-filter="IHC-P"> IHC-P </option> <option class="citation_filterRadio" value="application" data-filter="In Vivo"> In Vivo </option> <option class="citation_filterRadio" value="application" data-filter="Neutralization"> Neutralization </option> <option class="citation_filterRadio" value="application" data-filter="Western Blot"> Western Blot </option> </select> </div> <div class="select_wrapper filter_select"> <select id="selSampleType" title="Sample Types"> <option value="All">All Sample Types</option> <option class="citation_filterRadio" value="sampletype" data-filter="CSF"> CSF </option> <option class="citation_filterRadio" value="sampletype" data-filter="Cell Culture Supernates"> Cell Culture Supernates </option> <option class="citation_filterRadio" value="sampletype" data-filter="Cell Lysates"> Cell Lysates </option> <option class="citation_filterRadio" value="sampletype" data-filter="In Vivo"> In Vivo </option> <option class="citation_filterRadio" value="sampletype" data-filter="Tissue Homogenates"> Tissue Homogenates </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cells"> Whole Cells </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cells"> Whole Cells </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cells, Whole Tissue"> Whole Cells, Whole Tissue </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Tissue"> Whole Tissue </option> </select> </div> </div> </div> </div> <div class="row"> <ol id="citations" class="col-xs-12" data-expandall="false" data-max-citations="91" data-max-show="10"> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33005249"> The c‑Jun signaling pathway has a protective effect on nucleus pulposus cells in patients with intervertebral disc degeneration </a> </span><br/> Authors: Ming Lei, Kun Wang, Shuai Li, Kangcheng Zhao, Wenbin Hua, Xinghuo Wu et al.<br/> Experimental and Therapeutic Medicine<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24046361"> Sestrin-2, a repressor of PDGFR beta signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD </a> </span><br/> Authors: Juliana Heidler, Athanasios Fysikopoulos, Frank Wempe, Michael Seimetz, Thorsten Bangsow, Ana Tomasovic et al.<br/> Disease Models & Mechanisms<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/32927851"> TGF-beta Activity Related to the use of Collagen Membranes: In Vitro Bioassays </a> </span><br/> Authors: Layla Panahipour, Zahra Kargarpour, Bernadette Luza, Jung-Seok Lee, Reinhard Gruber<br/> International Journal of Molecular Sciences<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23872599"> M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination </a> </span><br/> Authors: Veronique E. Miron, Amanda Boyd, Jing-Wei Zhao, Tracy J. Yuen, Julia M. Ruckh, Jennifer L. Shadrach et al.<br/> Nature Neuroscience<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28871261"> The Chronic Stages of Bovine Fasciola hepatica Are Dominated by CD4 T-Cell Exhaustion </a> </span><br/> Authors: Divya Sachdev, Kevin C. Gough, Robin J. Flynn<br/> Frontiers in Immunology<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/27459702"> Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model </a> </span><br/> Authors: Rupak Pathak, Junru Wang, Sarita Garg, Nukhet Aykin-Burns, Karl-Uwe Petersen, Martin Hauer-Jensen<br/> Radiation Research<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/31360169"> Inhibition of TGF-beta 1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-beta 1-Induced EMT in Renal Fibrosis </a> </span><br/> Authors: Aurore Devocelle, Lola Lecru, Hélène François, Christophe Desterke, Cindy Gallerne, Pierre Eid et al.<br/> International Journal of Cell Biology<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24221580"> TGF-beta RI kinase activity mediates Emdogain-stimulated in vitro osteoclastogenesis </a> </span><br/> Authors: Reinhard Gruber, Gilles Roos, Jordi Caballé-Serrano, Rick Miron, Dieter D. 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Buckley, Manda S. Krishnaveni, Per Flodby, Mickael Dubourd, Agnes Banfalvi et al.<br/> The Journal of Pathology<br/> </li> <li class="top-lined" data-species="Mouse" data-application="In Vivo" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37404624"> Potential contribution of immature myeloid CD11c+dendritic cells-derived osteoclast precursor to inflammation-induced bone loss in the TRAF6-null chimeras in-vivo </a> </span><br/> Authors: Liu, YCG;Teng, AY;<br/> Journal of dental sciences<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: In Vivo </li> <li class="top-lined" data-species="Human" data-application="IHC" data-sampletype="Whole Tissue"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35989975"> Expression of TGF-beta and MMP-2 in hereditary gingival fibromatosis epithelial cells. A possible contribution of the epithelium to its pathogenesis </a> </span><br/> Authors: NM Kamal, MA Hamouda, N Abdelgawad<br/> Journal of oral biology and craniofacial research, 2022-08-14;12(5):617-622.<br/> Species: Human<br/> Sample Types: Whole Tissue<br/> Applications: IHC </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34835072"> Inhibition of miR-155 Promotes TGF-beta Mediated Suppression of HIV Release in the Cervical Epithelial Cells </a> </span><br/> Authors: J Gokavi, S Sadawarte, A Shelke, U Kulkarni-K, M Thakar, V Saxena<br/> Viruses, 2021-11-12;13(11):.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33995680"> TGF-&beta loaded exosome enhances ischemic wound healing in vitro and in vivo </a> </span><br/> Authors: A Shi, J Li, X Qiu, M Sabbah, S Boroumand, TC Huang, C Zhao, A Terzic, A Behfar, SL Moran<br/> Theranostics, 2021-04-30;11(13):6616-6631.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33217999"> Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging </a> </span><br/> Authors: YE Choi, MJ Song, M Hara, K Imanaka-Yo, DH Lee, JH Chung, ST Lee<br/> Int J Mol Sci, 2020-11-18;21(22):.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33202935"> TGF-&beta in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis </a> </span><br/> Authors: L Panahipour, Z Kargarpour, M Laggner, M Mildner, HJ Ankersmit, R Gruber<br/> Int J Mol Sci, 2020-11-13;21(22):.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/31746427"> Roxatidine inhibits fibrosis by inhibiting NF?kappaB and MAPK signaling in macrophages sensing breast implant surface materials </a> </span><br/> Authors: L Ji, T Wang, L Tian, H Song, M Gao<br/> Mol Med Rep, 2019-11-12;0(0):.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/30301599"> Cervical cancer cells produce TGF-?1 through the CD73-adenosine pathway and maintain CD73 expression through the autocrine activity of TGF-?1 </a> </span><br/> Authors: R García-Roc, A Monroy-Gar, J Hernández-, B Weiss-Stei, V Gutiérrez-, M Del Carmen, LR Ávila-Ibar, CA Don-López, DB Torres-Pin, M de Lourdes<br/> Cytokine, 2018-10-06;118(0):71-79.<br/> Species: Human<br/> Sample Types: Cell Culture Supernates<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Western Blot" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/29651226"> DNA methylation affects metastasis of renal cancer and is associated with TGF-?/RUNX3 inhibition </a> </span><br/> Authors: J Zheng, Y Mei, P Xiang, G Zhai, N Zhao, C Xu, M Liu, Z Pan, K Tang, D Jia<br/> Cancer Cell Int., 2018-04-10;18(0):56.<br/> Species: Human<br/> Sample Types: Cell Lysates<br/> Applications: Western Blot </li> <li class="top-lined" data-species="Mouse" data-application="Cell Culture" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/29339450"> Cardiac macrophages promote diastolic dysfunction </a> </span><br/> Authors: M Hulsmans, HB Sager, JD Roh, M Valero-Muñ, NE Houstis, Y Iwamoto, Y Sun, RM Wilson, G Wojtkiewic, B Tricot, MT Osborne, J Hung, C Vinegoni, K Naxerova, DE Sosnovik, MR Zile, AD Bradshaw, R Liao, A Tawakol, R Weissleder, A Rosenzweig, FK Swirski, F Sam, M Nahrendorf<br/> J. Exp. Med., 2018-01-16;0(0):.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: Cell Culture </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/29224017"> The IL-2/Anti-IL-2 Complex Attenuates Cardiac Ischaemia-Reperfusion Injury Through Expansion of Regulatory T Cells </a> </span><br/> Authors: J Xiao, K Yu, M Li, C Xiong, Y Wei, Q Zeng<br/> Cell. Physiol. Biochem., 2017-12-07;44(5):1810-1827.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/29212908"> Naive CD4(+) T Cells Carrying a TLR2 Agonist Overcome TGF-beta-Mediated Tumor Immune Evasion. </a> </span><br/> Authors: Ibrahim M, Scozzi D, Toth K, Ponti D, Kreisel D, Menna C, De Falco E, D'Andrilli A, Rendina E, Calogero A, Krupnick A, Gelman A<br/> J Immunol, 2017-12-06;200(2):847-856.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/29161287"> TGF-? contamination of purified recombinant GDF15 </a> </span><br/> Authors: OE Olsen, A Skjærvik, BF Størdal, A Sundan, T Holien<br/> PLoS ONE, 2017-11-21;12(11):e0187349.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28768908"> Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice </a> </span><br/> Authors: R Rouf, EG MacFarlane, E Takimoto, R Chaudhary, V Nagpal, PP Rainer, JG Bindman, EE Gerber, D Bedja, C Schiefer, KL Miller, G Zhu, L Myers, N Amat-Alarc, DI Lee, N Koitabashi, DP Judge, DA Kass, HC Dietz<br/> JCI Insight, 2017-08-03;2(15):.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28512472"> Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-? Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation </a> </span><br/> Authors: N Selvamurug, Z He, D Rifkin, B Dabovic, NC Partridge<br/> Stem Cells Int, 2017-04-23;2017(0):2450327.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse, Rat" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28389473"> ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury </a> </span><br/> Authors: Y Yang, H Liu, H Zhang, Q Ye, J Wang, B Yang, L Mao, W Zhu, RK Leak, B Xiao, B Lu, J Chen, X Hu<br/> J. Neurosci., 2017-04-07;0(0):.<br/> Species: Mouse, Rat<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28106121"> Endoplasmic Reticulum Oxidative Stress Triggers Tgf-Beta-Dependent Muscle Dysfunction by Accelerating Ascorbic Acid Turnover </a> </span><br/> Authors: D Pozzer, M Favellato, M Bolis, RW Invernizzi, F Solagna, B Blaauw, E Zito<br/> Sci Rep, 2017-01-20;7(0):40993.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/27599751"> MXRA5 is a TGF-?1-regulated human protein with anti-inflammatory and anti-fibrotic properties </a> </span><br/> J Cell Mol Med, 2016-09-06;0(0):.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Western Blot" data-sampletype="Tissue Homogenates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/27525437"> Lymphatic vessels regulate immune microenvironments in human and murine melanoma </a> </span><br/> J Clin Invest, 2016-08-15;0(0):.<br/> Species: Human<br/> Sample Types: Tissue Homogenates<br/> Applications: Western Blot </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/27104863"> TGF-? Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions </a> </span><br/> Authors: X Chen, DL Rateri, DA Howatt, A Balakrishn, JJ Moorleghen, LA Cassis, A Daugherty<br/> PLoS ONE, 2016-04-22;11(4):e0153811.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26800359"> Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. </a> </span><br/> Authors: Veltmann M, Hollborn M, Reichenbach A, Wiedemann P, Kohen L, Bringmann A<br/> PLoS ONE, 2016-01-22;11(1):e0147312.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" 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Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24833264"> Platelets provoke distinct dynamics of immune responses by differentially regulating CD4+ T-cell proliferation. </a> </span><br/> Authors: Zhu L, Huang Z, Stalesen R, Hansson G, Li N<br/> J Thromb Haemost, 2014-06-27;12(7):1156-65.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Rat" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24719328"> Expression of versican V3 by arterial smooth muscle cells alters tumor growth factor beta (TGFbeta)-, epidermal growth factor (EGF)-, and nuclear factor kappaB (NFkappaB)-dependent signaling pathways, creating a microenvironment that resists monocyte adhesion. </a> </span><br/> Authors: Kang I, Yoon D, Braun K, Wight T<br/> J Biol Chem, 2014-04-09;289(22):15393-404.<br/> Species: Rat<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24638085"> Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-beta and induce Tregs development via TGF-beta. </a> </span><br/> Authors: Xu S, Zhu J, Wu Z<br/> PLoS ONE, 2014-03-17;9(3):e91709.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25495560"> Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. </a> </span><br/> Authors: Bernard M, Dieude M, Yang B, Hamelin K, Underwood K, Hebert M<br/> Autophagy, 2014-01-01;10(12):2193-207.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23833258"> IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells. </a> </span><br/> Authors: Kim M, Koo T, Yan J, Lee E, Han K, Jeong J, Ro H, Kim B, Jo S, Oh K, Surh C, Ahn C, Yang J<br/> J Am Soc Nephrol, 2013-07-05;24(10):1529-36.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23152566"> Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade. </a> </span><br/> Authors: Olson B, Jankowska-Gan E, Becker J, Vignali D, Burlingham W, McNeel D<br/> J Immunol, 2012-11-14;189(12):5590-601.<br/> Species: Human<br/> Sample Types: In Vivo<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22948158"> Toll-like Receptor 2 (TLR2), Transforming Growth Factor-beta, Hyaluronan (HA), and Receptor for HA-mediated Motility (RHAMM) Are Required for Surfactant Protein A-stimulated Macrophage Chemotaxis. </a> </span><br/> Authors: Foley J, Lam D, Jiang H, Liao J, Cheong N, McDevitt T, Zaman A, Wright J, Savani R<br/> J Biol Chem, 2012-09-04;287(44):37406-19.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22762273"> Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis. </a> </span><br/> Authors: Lauzier A, Charbonneau M, Paquette M, Harper K, Dubois CM<br/> Arthritis Res. Ther., 2012-07-04;14(4):R159.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="ICC" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22118468"> Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. </a> </span><br/> Authors: Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H<br/> Cell, 2011-11-23;147(5):1146-58.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: ICC </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22005303"> Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. </a> </span><br/> Authors: Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y<br/> J. Clin. Invest., 2011-10-17;121(11):4548-66.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/21765905"> IL-33 induces IL-9 production in human CD4+ T cells and basophils. </a> </span><br/> Authors: Blom L, Poulsen BC, Jensen BM, Hansen A, Poulsen LK<br/> PLoS ONE, 2011-07-06;6(7):e21695.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/20643338"> The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. </a> </span><br/> Authors: Suzuki K, Maruya M, Kawamoto S<br/> Immunity, 2010-07-23;33(1):71-83.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/19139386"> Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. </a> </span><br/> Authors: King VL, Lin AY, Kristo F, Anderson TJ, Ahluwalia N, Hardy GJ, Owens AP, Howatt DA, Shen D, Tager AM, Luster AD, Daugherty A, Gerszten RE<br/> Circulation, 2009-01-12;119(3):426-35.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/18981246"> Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4. </a> </span><br/> Authors: Chase JC, Celli J, Bosio CM<br/> Infect. Immun., 2008-11-03;77(1):180-95.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Rat" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/18684975"> Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. </a> </span><br/> Authors: Akool el-S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W<br/> J. Immunol., 2008-08-15;181(4):2831-45.<br/> Species: Rat<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Rat" data-application="ICC" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/17909060"> Local administration of interleukin-11 ameliorates intestinal radiation injury in rats. </a> </span><br/> Authors: Boerma M, Wang J, Burnett AF, Santin AD, Roman JJ, Hauer-Jensen M<br/> Cancer Res., 2007-10-01;67(19):9501-6.<br/> Species: Rat<br/> Sample Types: Whole Cells<br/> Applications: ICC </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/17761617"> Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease. </a> </span><br/> Authors: Alcorn JF, Rinaldi LM, Jaffe EF, van Loon M, Bates JH, Janssen-Heininger YM, Irvin CG<br/> Am. J. Respir. Crit. Care Med., 2007-08-29;176(10):974-82.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/17673689"> Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. </a> </span><br/> Authors: Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ<br/> Am. J. Respir. Cell Mol. Biol., 2007-08-02;38(1):95-104.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/17554258"> Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? </a> </span><br/> Authors: McLennan SV, Kelly DJ, Schache M, Waltham M, Dy V, Langham RG, Yue DK, Gilbert RE<br/> Kidney Int., 2007-06-06;72(4):481-8.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/17237794"> Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. </a> </span><br/> Authors: Cohn RD, van Erp C, Habashi JP, Soleimani AA, Klein EC, Lisi MT, Gamradt M, ap Rhys CM, Holm TM, Loeys BL, Ramirez F, Judge DP, Ward CW, Dietz HC<br/> Nat. Med., 2007-01-21;13(2):204-10.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Rat" data-application="Neutralization" data-sampletype="CSF"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/17156928"> Increase in transforming growth factor-beta in the brain during infection is related to fever, not depression of spontaneous motor activity. </a> </span><br/> Authors: Matsumura S, Shibakusa T, Fujikawa T, Yamada H, Inoue K, Fushiki T<br/> Neuroscience, 2006-12-06;144(3):1133-40.<br/> Species: Rat<br/> Sample Types: CSF<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Electron Microscopy, ICC, IHC-P, Neutralization" data-sampletype="Whole Cells, Whole Tissue"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/16192635"> Uptake of host cell transforming growth factor-beta by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion. </a> </span><br/> Authors: Waghabi MC, Keramidas M, Bailly S, Degrave W, Mendonca-Lima L, Soeiro Mde N, Meirelles Mde N, Paciornik S, Araujo-Jorge TC, Feige JJ<br/> Am. J. Pathol., 2005-10-01;167(4):993-1003.<br/> Species: Mouse<br/> Sample Types: Whole Cells, Whole Tissue<br/> Applications: Electron Microscopy, ICC, IHC-P, Neutralization </li> <li class="top-lined" data-species="Rat" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/16183640"> Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway. </a> </span><br/> Authors: Akool el-S, Doller A, Muller R, Gutwein P, Xin C, Huwiler A, Pfeilschifter J, Eberhardt W<br/> J. Biol. Chem., 2005-09-23;280(47):39403-16.<br/> Species: Rat<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mink, Mouse" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/15728547"> Thrombospondin plays a vital role in the immune privilege of the eye. </a> </span><br/> Authors: Zamiri P, Masli S, Kitaichi N, Taylor AW, Streilein JW<br/> Invest. Ophthalmol. Vis. Sci., 2005-03-01;46(3):908-19.<br/> Species: Mink, Mouse<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Mouse" data-application="Western Blot" data-sampletype="Tissue Homogenates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/15649710"> Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice. </a> </span><br/> Authors: Mesples B, Fontaine RH, Lelievre V, Launay JM, Gressens P<br/> Neurobiol. Dis., 2005-02-01;18(1):193-205.<br/> Species: Mouse<br/> Sample Types: Tissue Homogenates<br/> Applications: Western Blot </li> <li class="top-lined" data-species="Bovine, Mouse" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/15128595"> Immunoneutralization of growth differentiation factor 9 reveals it partially accounts for mouse oocyte mitogenic activity. </a> </span><br/> Authors: Gilchrist RB, Ritter LJ, Cranfield M, Jeffery LA, Amato F, Scott SJ, Myllymaa S, Kaivo-Oja N, Lankinen H, Mottershead DG, Groome NP, Ritvos O<br/> Biol. Reprod., 2004-05-05;71(3):732-9.<br/> Species: Bovine, Mouse<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Primate - Macaca mulatta (Rhesus Macaque)" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/15100322"> Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. </a> </span><br/> Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ<br/> J. Immunol., 2004-05-01;172(9):5753-64.<br/> Species: Primate - Macaca mulatta (Rhesus Macaque)<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Human" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/15100259"> Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. </a> </span><br/> Authors: Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA<br/> J. Immunol., 2004-05-01;172(9):5213-21.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="Goat" data-application="IHC-P" data-sampletype="Whole Tissue"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/15021163"> Effect of weightbearing on bone formation during distraction osteogenesis. </a> </span><br/> Authors: Leung KS, Cheung WH, Yeung HY, Lee KM, Fung KP<br/> Clin. Orthop. Relat. Res., 2004-02-01;0(419):251-7.<br/> Species: Goat<br/> Sample Types: Whole Tissue<br/> Applications: IHC-P </li> <li class="top-lined" data-species="Rat" data-application="IHC-P" data-sampletype="Whole Tissue"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/12945801"> Connective tissue growth factor and its correlation to other growth factors in experimental granulation tissue. </a> </span><br/> Authors: Inkinen K, Wolff H, Lindroos P, Ahonen J<br/> Connect. Tissue Res., 2003-01-01;44(1):19-29.<br/> Species: Rat<br/> Sample Types: Whole Tissue<br/> Applications: IHC-P </li> <li class="top-lined" data-species="Mouse" data-application="Neutralization" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/11796519"> Estrogen inhibition of PTH-stimulated osteoclast formation and attachment in vitro: involvement of both PKA and PKC. </a> </span><br/> Authors: Liu BY, 2019, Wu PW, Bringhurst FR, Wang JT<br/> 141-147, 2002-02-01;143(2):627-35.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: Neutralization </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/20101093"> TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice </a> </span><br/> Authors: Yu Wang, Hafid Ait-Oufella, Olivier Herbin, Philippe Bonnin, Bhama Ramkhelawon, Soraya Taleb et al.<br/> Journal of Clinical Investigation<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/31645014"> Effect of seminal plasma or transforming growth factor on bovine endometrial cells </a> </span><br/> Authors: Jason A Rizo, Laila A Ibrahim, Paula C C Molinari, Bo R Harstine, Rachel L Piersanti, John J Bromfield<br/> Reproduction<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25406396"> Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking alpha V beta 8-TGF beta signaling in the brain </a> </span><br/> Authors: Thomas D. Arnold, Colin Niaudet, Mei-Fong Pang, Julie Siegenthaler, Konstantin Gaengel, Bongnam Jung et al.<br/> Development<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/21862019"> Activation of human vascular cells decreases their expression of transforming growth factor-beta </a> </span><br/> Authors: Amir H. Lebastchi, Lingfeng Qin, Salman F. Khan, Jing Zhou, Arnar Geirsson, Richard W. Kim et al.<br/> Atherosclerosis<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/29118338"> Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model </a> </span><br/> Authors: TR Karhadkar, D Pilling, N Cox, RH Gomer<br/> Sci Rep, 2017-11-08;7(1):15069.<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/9813100"> TGF-beta Plays a Key Role in Morphogenesis of the Pancreatic Islets of Langerhans by Controlling the Activity of the Matrix Metalloproteinase MMP-2 </a> </span><br/> Authors: Francisco Miralles, Tadej Battelino, Paul Czernichow, Raphael Scharfmann<br/> J. 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Ventura, Helena D'Anunciação de Oliveira, Leonardo C. Monção-Ribeiro, Bianca Gutfilen, Sergio A. L. de Souza et al.<br/> PLoS ONE<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/20679341"> Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase </a> </span><br/> Authors: Jenna E. Fong, Damien Le Nihouannen, Svetlana V. Komarova<br/> Journal of Biological Chemistry<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/30373226"> The Controversial Role of TGF-beta in Neovascular Age-Related Macular Degeneration Pathogenesis </a> </span><br/> Authors: Gian Marco Tosi, Maurizio Orlandini, Federico Galvagni<br/> International Journal of Molecular Sciences<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/15466481"> Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung </a> </span><br/> Authors: Katri Koli, Frank Wempe, Anja Sterner-Kock, Anna Kantola, Martina Komor, Wolf-K. Hofmann et al.<br/> The Journal of Cell Biology<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33062840"> Donor HLA−DR Drives the Development of De Novo Autoimmunity Following Lung and Heart Transplantation </a> </span><br/> Authors: Ewa Jankowska−Gan, Vrushali V. Agashe, Diego A. Lema, Ying Zhou, Laura Gonzalez Bosc, Jeremy A. Sullivan et al.<br/> Transplantation Direct<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26239057"> Vitamin C attenuates the toxic effect of aristolochic acid on renal tubular cells via decreasing oxidative stress-mediated cell death pathways </a> </span><br/> Authors: TSAI-KUN WU, CHYOU-WEI WEI, YING-RU PAN, SHUR-HUEIH CHERNG, WEI-JUNG CHANG, HSUEH-FANG WANG et al.<br/> Molecular Medicine Reports<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33477984"> Micellar Casein and Whey Powder Hold a TGF-beta Activity and Regulate ID Genes In Vitro </a> </span><br/> Authors: Layla Panahipour, Selma Husejnovic, Jila Nasirzade, Stephan Semelmayer, Reinhard Gruber<br/> Molecules<br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22093101"> A protective role for periostin and TGF ‐ beta in IgE ‐mediated allergy and airway hyperresponsiveness </a> </span><br/> Authors: E. D. Gordon, S. S. Sidhu, Z.‐E. Wang, P. G. Woodruff, S. Yuan, M. C. Solon et al.<br/> Clinical & Experimental Allergy<br/> </li> </div> </ol> </div> <div class="clearfix"><button class="btn btn-quinary ds_extra_cits pull-right toggle_cits_down" id="toggle_cits"></button></div> </div> </div> <div class="tab_content tab_4" data-tab="4" data-tabname="product-faqs" id="product-faqs"> <h2>FAQs</h2> <div class="row"> <div class="col-xs-12"> <ol id="faq_list"> <li> <span class="faq_question"><p>Does TGF-beta Pan Specific Antibody, catalog # AB-100-NA, recognize active or latent TGF-beta (LAP)?</p></span> <ul class="faq_answer"> <li><p>This antibody recognizes mature (active) TGF-beta. We have not tested for cross-reactivity to LAP (catalog # 246-LP) in our neutralization assay. Some cross-reactivity to latent TGF-beta may also be observed in western blot.</p></li> </ul> </li> </ol> <a class="btn btn-quinary view_all_faqs_btn" href="/resources/faqs/primary-antibodies"> View all Antibody FAQs </a> </div> </div> </div> <div class="tab_content tab_5" data-tab="5" data-tabname="product-supplemental" id="supplemental-products"> <div id="supplemental-products-tab-content-placeholder" class="tab-content-placeholder" data-id="supplemental-products" data-catalog_number="ab-100-na" data-language="en"> <div class="et_spinner_small"></div> Loading... </div> </div> <div class="tab_content tab_6" data-tab="6" data-tabname="product-reviews" id="reviews"> <h3>Reviews for TGF-beta Pan Specific Antibody</h3> <div class="row"> <div class="col-xs-12"> <div class="datasheet_section"> <div class="row"> <div class="col-md-6"> <p> Average Rating: 4.3 <span class="review_stars_4"></span> (Based on 3 Reviews) </p> <div class="review_rating_progress"> <div class="row"> <div class="col-xs-3"> 5 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="33.333333333333" aria-valuemin="0" aria-valuemax="100" style="width:33.333333333333%"> </div> </div> </div> <div class="col-xs-3"> 33.33% </div> </div> <div class="row"> <div class="col-xs-3"> 4 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="66.666666666667" aria-valuemin="0" aria-valuemax="100" style="width:66.666666666667%"> </div> </div> </div> <div class="col-xs-3"> 66.67% </div> </div> <div class="row"> <div class="col-xs-3"> 3 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 2 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 1 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> </div> </div> <div class="col-md-6"> <div class="well"> <h4>Have you used TGF-beta Pan Specific Antibody?</h4> <h5><strong>Submit a review and receive an Amazon gift card.</strong></h5> <div class="review_reward_txt"> <p>$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image</p> <p>$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image</p> </div> <a class="btn btn-quinary" href="/reviews/AB-100-NA"> Submit a Review </a> </div> </div> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <div class="reviews_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper"> <select class="review_filter_rating"> <option value="all">All Ratings</option> <option value="5">5</option> <option value="4">4</option> </select> </div> <div class="select_wrapper"> <select class="review_filter_application"> <option value="all">All Applications</option> <option value="IHC"> IHC </option> <option value="Flow"> Flow </option> <option value="B/N"> B/N </option> </select> </div> <div class="select_wrapper"> <select class="review_filter_species"> <option value="all">All Species</option> <option value="Human"> Human </option> <option value="Mouse"> Mouse </option> </select> </div> </div> </div> </div> <br/> <div class="review_row" data-rating="4" data-species="Mouse" data-application="IHC"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_4">TGF-beta Pan Specific Antibody</div> <div class="review_date">By <span class="review_reviewer">Tina Yuan</span> on 11/23/2020 </div> <div class="row"> <div class="review_specifics col-xs-12"> <span class="ds_review_data"> <strong>Application:</strong> IHC </span> <span class="ds_review_data"> <strong>Sample Tested: </strong> mouse oral tissue </span> <span class="ds_review_data"><strong>Species:</strong> Mouse </span> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ab-100-na_59251_0.png" data-title="Immunohistochemistry TGF-beta Pan Specific Antibody AB-100-NA" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Immunohistochemistry TGF-beta Pan Specific Antibody AB-100-NA" title="Immunohistochemistry TGF-beta Pan Specific Antibody AB-100-NA" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ab-100-na_59251_0.png"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="Human" data-application="Flow"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">TGF-beta Pan Specific Antibody</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 03/23/2018 </div> <div class="row"> <div class="review_specifics col-xs-12"> <span class="ds_review_data"> <strong>Application:</strong> Flow </span> <span class="ds_review_data"> <strong>Sample Tested: </strong> Blood mononuclear cells (PBMCs) </span> <span class="ds_review_data"><strong>Species:</strong> Human </span> </div> </div> </div> </div> <hr/> </div> <div class="review_row" data-rating="4" data-species="Mouse" data-application="B/N"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_4">TGF-beta Pan Specific 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