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6</title> <meta name="description" content="Search results for: Interleukin 6"> <meta name="keywords" content="Interleukin 6"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Interleukin 6"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 9</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Interleukin 6</h1> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Association of G-174C Polymorphism of the Interleukin-6 Gene Promoter with Obesity in Iranian Population</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Rostami%20F">Rostami F</a>, <a href="https://publications.waset.org/search?q=Haj%20Hosseini%20R"> Haj Hosseini R</a>, <a href="https://publications.waset.org/search?q=Sharifi%20K"> Sharifi K</a>, <a href="https://publications.waset.org/search?q=Daneshpour%20M"> Daneshpour M</a>, <a href="https://publications.waset.org/search?q=Azizi%20F"> Azizi F</a>, <a href="https://publications.waset.org/search?q=Hedayati%20M"> Hedayati M</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Expression and secretion of inflammation markers are disturbed in obesity. Interleukin-6 reduces body fat mass. The common G-174C polymorphism in the promoter of IL-6 gene has been reported that effects on transcriptional regulation. The objective was to investigate association of the common polymorphism G-174C with obesity in Iranian population. The present study is cross sectional association study that included 242 individuals (110 men and 132 women). Serum IL-6 levels, C-reactive protein, fasting blood glucose and blood lipids profile were measured .BMI and WHR were calculated. Genotyping is carried out by PCR and RFLP. The frequencies of G and C allele were 64.5% and 35.5%, respectively. The G-174C polymorphism was not associated with BMI and WHR. However in obese individual, fasting blood glucose was significantly higher in carrier of C allele compared with the noncarrier. The IL-6 G-174C polymorphism is not a risk factor for obesity in Iranian population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Interleukin%206" title="Interleukin 6">Interleukin 6</a>, <a href="https://publications.waset.org/search?q=Polymorphism%20genetic" title=" Polymorphism genetic"> Polymorphism genetic</a>, <a href="https://publications.waset.org/search?q=Obesity." title=" Obesity."> Obesity.</a> </p> <a href="https://publications.waset.org/9024/association-of-g-174c-polymorphism-of-the-interleukin-6-gene-promoter-with-obesity-in-iranian-population" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9024/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9024/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9024/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9024/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9024/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9024/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9024/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9024/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9024/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9024/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9024.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1610</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> The Effect of Aerobic Training and Taxol Consumption on IL 8 and PAI-1 in Cervical Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Alireza%20Barari">Alireza Barari</a>, <a href="https://publications.waset.org/search?q=Maryam%20Firoozi"> Maryam Firoozi</a>, <a href="https://publications.waset.org/search?q=Maryam%20Ebrahimzadeh"> Maryam Ebrahimzadeh</a>, <a href="https://publications.waset.org/search?q=Romina%20Roohani%20Ardeshiri"> Romina Roohani Ardeshiri</a>, <a href="https://publications.waset.org/search?q=Maryam%20Kamarloeei"> Maryam Kamarloeei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Background: The purpose of this study was to analyze the effect of six-week aerobic training and taxol consumption on interleukin-8 and Plasminogen Activator Inhibitor-1 (PAI-1) in mice with cervical cancer. Materials and Methods: In this experimental study, 40 female C57 mice with cervical cancer, eight weeks old, were randomly divided into 4 groups including: control, taxol supplement, training, and training-taxol supplement. The implantation of cancerous tumors was performed under the skin at the upper of the pelvis. The program training was included: endurance training for six weeks, 3 sessions per week and 50 minutes per session, at the speed of 14-18 m/s. Taxol supplement at a dose of 60 mg/kg per day was injected intraperitoneally. Data analysis was performed using t-test and one-way ANOVA and if statistically significant, Bonferroni post hoc was used at the significance level p < .05. Results: The results showed that there was a significant difference between the levels of interleukin 8 (P < 0.05, F = 12.25) and the PAI-1 (P < 0.05, P = 0.10737 between the 4 groups. The results of this study showed a significant difference between the control group and the training - complementary group. Six weeks of aerobic training and taxol consumption have a significant effect on the level of PAI-1 and interleukin-8 mice with cervical cancer. Conclusion: Considering the effect of training on these variables, this type of exercise can be used as a complementary therapeutic approach with other therapies for cervical cancer.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Cervical%20cancer" title="Cervical cancer">Cervical cancer</a>, <a href="https://publications.waset.org/search?q=taxol" title=" taxol"> taxol</a>, <a href="https://publications.waset.org/search?q=endurance%20training" title=" endurance training"> endurance training</a>, <a href="https://publications.waset.org/search?q=interleukin%208" title=" interleukin 8"> interleukin 8</a>, <a href="https://publications.waset.org/search?q=plasminogen%20activator%20inhibitor-1." title=" plasminogen activator inhibitor-1."> plasminogen activator inhibitor-1.</a> </p> <a href="https://publications.waset.org/10013134/the-effect-of-aerobic-training-and-taxol-consumption-on-il-8-and-pai-1-in-cervical-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10013134/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10013134/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10013134/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10013134/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10013134/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10013134/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10013134/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10013134/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10013134/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10013134/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10013134.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">369</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Development of an Immunoassay Platform for Diagnosis of Acute Kidney Injury</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=T.%20Bovornvirakit">T. Bovornvirakit</a>, <a href="https://publications.waset.org/search?q=K.%20Viravaidya"> K. Viravaidya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Acute kidney injury (AKI) is a new worldwide public health problem. A diagnosis of this disease using creatinine is still a problem in clinical practice. Therefore, a measurement of biomarkers responsible for AKI has received much attention in the past couple years. Cytokine interleukin-18 (IL-18) was reported as one of the early biomarkers for AKI. The most commonly used method to detect this biomarker is an immunoassay. This study used a planar platform to perform an immunoassay using fluorescence for detection. In this study, anti-IL-18 antibody was immobilized onto a microscope slide using a covalent binding method. Make-up samples were diluted at the concentration between 10 to 1000 pg/ml to create a calibration curve. The precision of the system was determined using a coefficient of variability (CV), which was found to be less than 10%. The performance of this immunoassay system was compared with the measurement from ELISA. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Acute%20kidney%20injury" title="Acute kidney injury">Acute kidney injury</a>, <a href="https://publications.waset.org/search?q=Acute%20renal%20failure" title=" Acute renal failure"> Acute renal failure</a>, <a href="https://publications.waset.org/search?q=Antibody%0Aimmobilization" title=" Antibody immobilization"> Antibody immobilization</a>, <a href="https://publications.waset.org/search?q=Interleukin-18" title=" Interleukin-18"> Interleukin-18</a> </p> <a href="https://publications.waset.org/7578/development-of-an-immunoassay-platform-for-diagnosis-of-acute-kidney-injury" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/7578/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/7578/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/7578/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/7578/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/7578/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/7578/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/7578/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/7578/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/7578/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/7578/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/7578.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1606</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Modulation of Lipopolysaccharide Induced Interleukin-17F and Cyclooxygenase-2 Gene Expression by Echinacea purpurea in Broiler Chickens </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ali%20Asghar%20Saki">Ali Asghar Saki</a>, <a href="https://publications.waset.org/search?q=Sayed%20Ali%20Hosseini%20Siyar"> Sayed Ali Hosseini Siyar</a>, <a href="https://publications.waset.org/search?q=Abbass%20Ashoori"> Abbass Ashoori</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>This study was conducted to evaluate the effect of <em>Echinacea purpurea</em> on the expression of cyclooxygenase-2 (COX-2), interleukin-17F (IL-17F) in seven-day-old broiler chickens. Four groups were fed with concentration of 0 g/kg, 5 g/kg, 10 g/kg and 20 g/kg from the root of <em>E. purpurea</em> in the basal diet and two other groups were only fed with the basal diet for 21 days. At the 28<sup>th</sup> day, lipopolysaccharide (LPS, 2 mg/kg diet) was injected in four groups and the basal diet group was injected by saline as control. The chickens’ spleen RNA expression was measured for the COX-2 and IL-17F genes by Real-Time PCR. The results have shown that chickens which were fed <em>E. purpurea</em> had a lower COX-2 and IL-17F mRNA expression. The chickens who have received LPS only, lymphocyte was lower than other treatments. Vital organ weights were not significantly different, but body weight loss was recovered by dietary herbs inclusion. The results of this study have shown the positive effect of an anti-inflammatory herb to prevent the undesirable effect of inflammation.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Echinacea%20purpurea" title="Echinacea purpurea">Echinacea purpurea</a>, <a href="https://publications.waset.org/search?q=broiler%20chickens" title=" broiler chickens"> broiler chickens</a>, <a href="https://publications.waset.org/search?q=gene%20expression" title=" gene expression"> gene expression</a>, <a href="https://publications.waset.org/search?q=lipopolysaccharide." title=" lipopolysaccharide."> lipopolysaccharide.</a> </p> <a href="https://publications.waset.org/10008243/modulation-of-lipopolysaccharide-induced-interleukin-17f-and-cyclooxygenase-2-gene-expression-by-echinacea-purpurea-in-broiler-chickens" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10008243/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10008243/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10008243/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10008243/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10008243/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10008243/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10008243/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10008243/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10008243/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10008243/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10008243.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">988</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Ficus deltoidea Extract Protects HaCaT Keratinocytes from UVB Irradiation-Induced Inflammation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Rosnani%20Hasham">Rosnani Hasham</a>, <a href="https://publications.waset.org/search?q=Hyun%20Kyung%20Choi"> Hyun Kyung Choi</a>, <a href="https://publications.waset.org/search?q=Chang%20Seo%20Park"> Chang Seo Park</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Ficus deltoidea from the Moraceae family is a popular medicinal herb in Malaysia. It possesses strong antioxidant and antiinflammatory properties. In the present study, the anti-inflammatory effects of F. deltoidea extract on UVB-irradiated HaCaT Keratinocytes were investigated. HaCaT Keratinocytes were UVBirradiated (12.5 mJ/cm3) and were treated with 0.05, 0.08 or 0.1% of F. deltoidea extract. Cell viability following UVB irradiation was significantly higher in the groups treated with the F. deltoidea extract at doses of 0.05, 0.08 or 0.1% than in control group with UVB irradiation only. Tumor necrosis factor-α (TNF-α), interleukin-1α (IL-1α), interleukin-6 (IL-6) and cyclooxygenase (COX-2) play primary roles in the inflammation process upon UV irradiation and are known to be stimulated by UVB irradiation. Treatment with the F. deltoidea extract dramatically inhibited the UV-induced TNF-α, IL-1α, IL-6, and COX-2 expression. These results suggest that the F. deltoidea extract inhibits the production of pro-inflammatory cytokines and may be an effective protective agent for the treatment of skin diseases.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Ficus%20deltoidea" title="Ficus deltoidea">Ficus deltoidea</a>, <a href="https://publications.waset.org/search?q=anti-inflammatory%20activity" title=" anti-inflammatory activity"> anti-inflammatory activity</a>, <a href="https://publications.waset.org/search?q=cytokines" title=" cytokines"> cytokines</a>, <a href="https://publications.waset.org/search?q=COX-2." title=" COX-2."> COX-2.</a> </p> <a href="https://publications.waset.org/9999666/ficus-deltoidea-extract-protects-hacat-keratinocytes-from-uvb-irradiation-induced-inflammation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9999666/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9999666/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9999666/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9999666/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9999666/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9999666/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9999666/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9999666/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9999666/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9999666/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9999666.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2836</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Evaluation of the Immunoregulatory Activity of rFip-gts Purified from Baculovirus-infected Insect Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Tzong%20Yuan%20Wu">Tzong Yuan Wu</a>, <a href="https://publications.waset.org/search?q=Sheng%20Kuo%20Hsieh"> Sheng Kuo Hsieh</a>, <a href="https://publications.waset.org/search?q=Tzyy%20Rong%20Jinn"> Tzyy Rong Jinn</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Fip-gts, an immunomodulatory protein purified from Ganoderma tsugae, has been reported to possess therapeutic effects in the treatment of cancer and autoimmune disease. For medicinal application, a recombinant Fip-gts was successfully expressed and purified in Sf21 insect cells by our previously work. It is important to evaluate the immunomodulatory activity of the rFip-gts. To assess the immunomodulatory potential of rFip-gts, the T lymphocytes of murine splenocytes were used in the present study. Results revealed that rFip-gts induced cellular aggregation formation. Additionally, the expression of IL-2 and IFN-r were up-regulated after the treatment of rFip-gts, and a corresponding increased production of IL-2 and IFN-r in a dose-dependent manner. The results showed that rFip-gts has an immunomodulatory activity in inducing Th1 lymphocytes from murine splenocytes released IL-2 and IFN-γ, thus suggest that rFip-gts may have therapeutic potential in vivo as an immune modulator.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Fungal%20immunomodulatory%20protein" title="Fungal immunomodulatory protein">Fungal immunomodulatory protein</a>, <a href="https://publications.waset.org/search?q=Ganodermatsugae" title=" Ganodermatsugae"> Ganodermatsugae</a>, <a href="https://publications.waset.org/search?q=Interleukin%202" title=" Interleukin 2"> Interleukin 2</a>, <a href="https://publications.waset.org/search?q=Interferon%20%CE%B3" title=" Interferon 纬"> Interferon 纬</a>, <a href="https://publications.waset.org/search?q=Lingzhi." title=" Lingzhi."> Lingzhi.</a> </p> <a href="https://publications.waset.org/6918/evaluation-of-the-immunoregulatory-activity-of-rfip-gts-purified-from-baculovirus-infected-insect-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/6918/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/6918/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/6918/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/6918/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/6918/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/6918/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/6918/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/6918/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/6918/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/6918/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/6918.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1837</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Cutaneous Application of Royal Jelly Inhibits Skin Lesions in NC/Nga Mice, a Human-Like Mouse Model of Atopic Dermatitis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Junki%20Miyamoto">Junki Miyamoto</a>, <a href="https://publications.waset.org/search?q=Mariko%20Kiyomi"> Mariko Kiyomi</a>, <a href="https://publications.waset.org/search?q=Yuuki%20Nagashio"> Yuuki Nagashio</a>, <a href="https://publications.waset.org/search?q=Takuya%20Suzuki"> Takuya Suzuki</a>, <a href="https://publications.waset.org/search?q=Soichi%20Tanabe"> Soichi Tanabe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Anti-allergic effects of royal jelly were evaluated in a human-like mouse model of atopic dermatitis. NC/Nga mice were cutaneously applied with royal jelly for 6 weeks. Royal jelly-treated mice exhibited lower levels of serum total immunoglobulin E in comparison with controls. We found that the treatment decreased (11% to the control) expression of mRNA for aquaporin-3, which is involved in the modulation of epidermal hydration. Microarray analysis revealed more than 10-fold changes in the expression of several genes, such as transglutaminase 2, repetin, and keratins. In normal human epidermal keratinocytes, royal jelly extract suppressed interleukin-8 elevation induced by TNF-α and interferon-γ, suggesting direct anti-inflammatory activity in keratinocytes. Collectively, topical application of royal jelly may be useful for amelioration of lesions and inflammation in atopic dermatitis.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Aquaporin%203" title="Aquaporin 3">Aquaporin 3</a>, <a href="https://publications.waset.org/search?q=immunoglobulin%20E" title=" immunoglobulin E"> immunoglobulin E</a>, <a href="https://publications.waset.org/search?q=NC%2FNga" title=" NC/Nga"> NC/Nga</a>, <a href="https://publications.waset.org/search?q=royal%0D%0Ajelly." title=" royal jelly."> royal jelly.</a> </p> <a href="https://publications.waset.org/16309/cutaneous-application-of-royal-jelly-inhibits-skin-lesions-in-ncnga-mice-a-human-like-mouse-model-of-atopic-dermatitis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/16309/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/16309/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/16309/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/16309/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/16309/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/16309/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/16309/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/16309/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/16309/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/16309/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/16309.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1877</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Clinical Utility of Salivary Cytokines for Children with Attention Deficit Hyperactivity Disorder</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Masaki%20Yamaguchi">Masaki Yamaguchi</a>, <a href="https://publications.waset.org/search?q=Daimei%20Sasayama"> Daimei Sasayama</a>, <a href="https://publications.waset.org/search?q=Shinsuke%20Washizuka"> Shinsuke Washizuka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The goal of this study was to examine the possibility of salivary cytokines for the screening of attention deficit hyperactivity disorder (ADHD) in children. We carried out a case-control study, including 19 children with ADHD and 17 healthy children (controls). A multiplex bead array immunoassay was used to conduct a multi-analysis of 27 different salivary cytokines. Six salivary cytokines (interleukin (IL)-1β, IL-8, IL12p70, granulocyte colony-stimulating factor (G-CSF), interferon gamma (IFN-γ), and vascular endothelial growth factor (VEGF)) were significantly associated with the presence of ADHD (p < 0.05). An informative salivary cytokine panel was developed using VEGF by logistic regression analysis (odds ratio: 0.251). Receiver operating characteristic analysis revealed that assessment of a panel using VEGF showed “good” capability for discriminating between ADHD patients and controls (area under the curve: 0.778). ADHD has been hypothesized to be associated with reduced cerebral blood flow in the frontal cortex, due to reduced VEGF levels. Our study highlights the possibility of utilizing differential salivary cytokine levels for point-of-care testing (POCT) of biomarkers in children with ADHD. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Cytokine" title="Cytokine">Cytokine</a>, <a href="https://publications.waset.org/search?q=saliva" title=" saliva"> saliva</a>, <a href="https://publications.waset.org/search?q=attention%20deficit%20hyperactivity%20disorder" title=" attention deficit hyperactivity disorder"> attention deficit hyperactivity disorder</a>, <a href="https://publications.waset.org/search?q=child" title=" child"> child</a>, <a href="https://publications.waset.org/search?q=biomarker." title=" biomarker."> biomarker.</a> </p> <a href="https://publications.waset.org/10010684/clinical-utility-of-salivary-cytokines-for-children-with-attention-deficit-hyperactivity-disorder" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10010684/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10010684/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10010684/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10010684/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10010684/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10010684/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10010684/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10010684/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10010684/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10010684/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10010684.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">713</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Investigating Prostaglandin E2 and Intracellular Oxidative Stress Levels in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages upon Treatment with Strobilanthes crispus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Anna%20Pick%20Kiong%20Ling">Anna Pick Kiong Ling</a>, <a href="https://publications.waset.org/search?q=Jia%20May%20Chin"> Jia May Chin</a>, <a href="https://publications.waset.org/search?q=Rhun%20Yian%20Koh"> Rhun Yian Koh</a>, <a href="https://publications.waset.org/search?q=Ying%20Pei%20Wong"> Ying Pei Wong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Uncontrolled inflammation may cause serious inflammatory diseases if left untreated. Non-steroidal anti-inflammatory drug (NSAIDs) is commonly used to inhibit pro-inflammatory enzymes, thus, reduce inflammation. However, long term administration of NSAIDs leads to various complications. Medicinal plants are getting more attention as it is believed to be more compatible with human body. One of them is a flavonoid-containing medicinal plants, <em>Strobilanthes crispus</em> which has been traditionally claimed to possess anti-inflammatory and antioxidant activities. Nevertheless, its anti-inflammatory activities are yet to be scientifically documented. Objectives: This study aimed to examine the anti-inflammatory activity of <em>S. crispus</em> by investigating its effects on intracellular oxidative stress and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) levels. Materials and Methods: In this study, the Maximum Non-toxic Dose (MNTD) of methanol extract of both leaves and stems of <em>S. crispus</em> was first determined using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenytetrazolium Bromide (MTT) assay. The effects of <em>S. crispus </em>extracts at MNTD and half MNTD (½MNTD) on intracellular ROS as well as PGE<sub>2</sub> levels in 1.0 µg/mL LPS-stimulated RAW 264.7 macrophages were then be measured using DCFH-DA and a competitive enzyme immunoassay kit, respectively. Results: The MNTD of leaf extract was determined as 700µg/mL while for stem was as low as 1.4µg/mL. When LPS-stimulated RAW 264.7 macrophages were subjected to the MNTD of <em>S. crispus </em>leaf extract, both intracellular ROS and PGE<sub>2</sub> levels were significantly reduced. In contrast, stem extract at both MNTD and ½MNTD did not significantly reduce the PGE<sub>2</sub> level, but significantly increased the intracellular ROS level. Conclusion: The methanol leaf extract of <em>S. crispus </em>may possess anti-inflammatory properties as it is able to significantly reduce the intracellular ROS and PGE<sub>2</sub> levels of LPS-stimulated cells. Nevertheless, further studies such as investigating the interleukin, nitric oxide and cytokine tumor necrosis factor-α (TNFα) levels has to be conducted to further confirm the anti-inflammatory properties of <em>S. crispus.</em> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Anti-inflammatory" title="Anti-inflammatory">Anti-inflammatory</a>, <a href="https://publications.waset.org/search?q=natural%20products" title=" natural products"> natural products</a>, <a href="https://publications.waset.org/search?q=prostaglandin%20E2" title=" prostaglandin E2"> prostaglandin E2</a>, <a href="https://publications.waset.org/search?q=reactive%20oxygen%20species." title=" reactive oxygen species."> reactive oxygen species.</a> </p> <a href="https://publications.waset.org/10004319/investigating-prostaglandin-e2-and-intracellular-oxidative-stress-levels-in-lipopolysaccharide-stimulated-raw-2647-macrophages-upon-treatment-with-strobilanthes-crispus" 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