Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="S5PQBK6OlYTjVpZrOyZGspnM8dmGPxjK5rmWdyvIXytn6aPJOz1G1y2jErKy0WoZ"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="S5PQBK6OlYTjVpZrOyZGspnM8dmGPxjK5rmWdyvIXytn6aPJOz1G1y2jErKy0WoZ"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="S5PQBK6OlYTjVpZrOyZGspnM8dmGPxjK5rmWdyvIXytn6aPJOz1G1y2jErKy0WoZ"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="S5PQBK6OlYTjVpZrOyZGspnM8dmGPxjK5rmWdyvIXytn6aPJOz1G1y2jErKy0WoZ"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="26517517"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 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'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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class="affiliation-link" title="The Biotherapy Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+Y&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yingnan Wang">Yingnan Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+S&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Shaochuan Wang">Shaochuan Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Gastrointestinal-Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cai+J&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jianye Cai">Jianye Cai</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="The Biotherapy Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shi+J&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jianqiang Shi">Jianqiang Shi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sui+X&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Xin Sui">Xin Sui</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi, China." href="#full-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cao+Y&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" 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class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Gastrointestinal-Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+M&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Maosheng Wang">Maosheng Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="The Cardiovascular Center, Gaozhou People's Hospital, Maoming, Guangdong, China." href="#full-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Xiang+AP&cauthor_id=26517517" ref="linksrc=author_name_link" 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</a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/26517517/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> The Biotherapy Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> <li data-affiliation-id="full-view-affiliation-2" id="full-view-affiliation-2" ><sup class="key">2</sup> Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> <li data-affiliation-id="full-view-affiliation-3" id="full-view-affiliation-3" ><sup class="key">3</sup> Department of Gastrointestinal-Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> <li data-affiliation-id="full-view-affiliation-4" id="full-view-affiliation-4" ><sup class="key">4</sup> Department of Radiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> <li data-affiliation-id="full-view-affiliation-5" id="full-view-affiliation-5" ><sup class="key">5</sup> Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi, China.</li> <li data-affiliation-id="full-view-affiliation-6" id="full-view-affiliation-6" ><sup class="key">6</sup> The Cardiovascular Center, Gaozhou People's Hospital, Maoming, Guangdong, China.</li> <li data-affiliation-id="full-view-affiliation-7" id="full-view-affiliation-7" ><sup class="key">7</sup> Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">26517517</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC4767474&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4767474/" data-ga-category="full_text" data-ga-action="PMCID" > PMC4767474 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.18632/oncotarget.5739&id_type=DOI" 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<div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Wang+J&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jiancheng Wang">Jiancheng Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="The Biotherapy Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+Y&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yingnan Wang">Yingnan Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+S&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Shaochuan Wang">Shaochuan Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Gastrointestinal-Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cai+J&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jianye Cai">Jianye Cai</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="The Biotherapy Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shi+J&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jianqiang Shi">Jianqiang Shi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sui+X&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Xin Sui">Xin Sui</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi, China." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cao+Y&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yong Cao">Yong Cao</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="The Cardiovascular Center, Gaozhou People's Hospital, Maoming, Guangdong, China." href="#short-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Huang+W&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Weijun Huang">Weijun Huang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chen+X&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Xiaoyong Chen">Xiaoyong Chen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cai+Z&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Zijie Cai">Zijie Cai</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Li+H&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hongyu Li">Hongyu Li</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bardeesi+AS&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Adham Sameer A Bardeesi">Adham Sameer A Bardeesi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+B&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bin Zhang">Bin Zhang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Liu+M&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Muyun Liu">Muyun Liu</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Song+W&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wu Song">Wu Song</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Gastrointestinal-Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+M&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Maosheng Wang">Maosheng Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="The Cardiovascular Center, Gaozhou People's Hospital, Maoming, Guangdong, China." href="#short-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Xiang+AP&cauthor_id=26517517" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Andy Peng Xiang">Andy Peng Xiang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="The Biotherapy Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China." href="#short-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> The Biotherapy Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> Department of Gastrointestinal-Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> <li data-affiliation-id="short-view-affiliation-4" id="short-view-affiliation-4" ><sup class="key">4</sup> Department of Radiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> <li data-affiliation-id="short-view-affiliation-5" id="short-view-affiliation-5" ><sup class="key">5</sup> Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi, China.</li> <li data-affiliation-id="short-view-affiliation-6" id="short-view-affiliation-6" ><sup class="key">6</sup> The Cardiovascular Center, Gaozhou People's Hospital, Maoming, Guangdong, China.</li> <li data-affiliation-id="short-view-affiliation-7" id="short-view-affiliation-7" ><sup class="key">7</sup> Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">26517517</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC4767474&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4767474/" data-ga-category="full_text" data-ga-action="PMCID" > PMC4767474 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.18632/oncotarget.5739&id_type=DOI" href="https://doi.org/10.18632/oncotarget.5739" data-ga-category="full_text" data-ga-action="DOI" > 10.18632/oncotarget.5739 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/26517517/citations/" data-citation-style="nlm" data-pubmed-format-link="/26517517/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Mesenchymal stem cells (MSCs) have recently been shown to home to tumors and contribute to the formation of the tumor-associated stroma. In addition, MSCs can secrete paracrine factors to facilitate tumor progression. However, the involvement of MSC-derived cytokines in colorectal cancer (CRC) angiogenesis and growth has not been clearly addressed. In this study, we report that interleukin-8 (IL-8) was the most highly upregulated pro-angiogenic factor in MSCs co-cultured with CRC cells and was expressed at substantially higher levels in MSCs than CRC cells. To evaluate the effect of MSC-derived IL-8 on CRC angiogenesis and growth, we used MSCs that expressed small hairpin (interfering) RNAs (shRNA) targeting IL-8 (shIL-8-MSCs). We found that MSC-secreted IL-8 promoted human umbilical vein endothelial cell (HUVEC) proliferation and migration, tube-formation ability and CRC cell proliferation. Additionally, in vivo studies showed that MSCs promoted tumor angiogenesis partially through IL-8. Taken together, these findings suggest that IL-8 secreted by MSCs promotes CRC angiogenesis and growth and can therefore serve as a potential novel therapeutic target. </p> </div> <p> <strong class="sub-title"> Keywords: </strong> angiogenesis; colorectal cancer; interleukin-8; mesenchymal stem cells. </p> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" data-ga-category="literature_resources" data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a> </p> <div class="conflict-of-interest" id="conflict-of-interest"> <h2 class="title"> Conflict of interest statement </h2> <div class="statement"> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one"><bold>CONFLICTS OF INTEREST</bold></p> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">No, there is no conflict of interest that I should disclose, having read the above statement.</p> </div> </div> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/29bc12cdc46e/oncotarget-06-42825-g001.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="546" data-image-height="683" data-image-alt="Figure 1" data-pmc-id="PMC4767474" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/8c4c625125d8/oncotarget-06-42825-g001.gif" alt="Figure 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="546"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="683"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1. CRC cells induce IL-8 production… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1. CRC cells induce IL-8 production in MSCs </p> </strong> <div class="figure-caption-contents"><b> A. </b> The expression of pro-angiogenic genes…</div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1. CRC cells induce IL-8 production in MSCs </strong> <div class="figure-caption-contents"><b>A.</b> The expression of pro-angiogenic genes by MSCs treated with recombinant IL-1β (30 ng/mL) and TNF-α (20 ng/mL) were determined using RNA-Seq data. The results are presented as a histogram. <b>B.</b> IL-8 protein levels in culture media determined by ELISA in MSCs pretreated with recombinant IL-1β (30 ng/mL) and TNF-α (20 ng/mL) for 36 h. The results are presented as the mean values from three independent experiments (**, <i>p</i> < 0.01). <b>C.</b> In a CRC cell/MSC transwell system, MSCs were co-cultured with CRC cells (SW480, LS174T and HT29). After 36 h, IL-8 mRNA expression was measured using qRT-PCR and normalized to β-actin mRNA (**, <i>p</i> < 0.01). <b>D.</b> IL-8 protein levels in culture media determined by ELISA in CRC cells and MSCs before and after co-culture for 36 h. The results are presented as the mean values from three independent experiments (**, <i>p</i> < 0.01). <b>E.</b> MSCs and SW480 were co-cultured in a transwell system and a direct contact system separately for 36 h, and IL-8 expression in SW480 and MSCs was measured using qRT-PCR. <b>F.</b> IL-8 protein levels in culture media determined by ELISA in a transwell system and a direct contact system of MSCs and SW480 for 36 h. The results are presented as the mean values from three independent experiments.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="figure-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/10a4980d880c/oncotarget-06-42825-g002.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="741" data-image-height="986" data-image-alt="Figure 2" data-pmc-id="PMC4767474" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/325cae7b7436/oncotarget-06-42825-g002.gif" alt="Figure 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="741"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="986"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2. MSCs promote endothelial cell proliferation… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2. MSCs promote endothelial cell proliferation and migration through IL-8 secretion </p> </strong> <div class="figure-caption-contents"><b> A. </b> The numbers…</div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2. MSCs promote endothelial cell proliferation and migration through IL-8 secretion </strong> <div class="figure-caption-contents"><b>A.</b> The numbers of HUVECs following culture with fresh medium or conditioned medium from CRC cells, CRC cell/MSC co-cultures, or CRC cell/shIL-8-MSC co-cultures were determined every day for 5 days. The cell counts are presented as the mean values from three independent experiments using a hemocytometer (*, <i>p</i> < 0.05). <b>B.</b> HUVECs were cultured with conditioned medium as indicated in (A), and Ki-67 mRNA expression in HUVECs was measured by qRT-PCR (*, <i>p</i> < 0.05). <b>C.</b> Assay of HUVEC migration in response to different conditioned media using 8-μm-pore membrane filters. Calcein AM-stained cells indicates HUVECs that migrated through the transwell membrane. Scale bar, 100 μm. <b>D.</b> The numbers of HUVECs that passed through the filters was counted. The cell counts are presented as the mean values per field from at least five randomly selected fields from three independent experiments (*, <i>p</i> < 0.05).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="figure-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/8656a54b82e7/oncotarget-06-42825-g003.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="744" data-image-height="752" data-image-alt="Figure 3" data-pmc-id="PMC4767474" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/612f80ed8804/oncotarget-06-42825-g003.gif" alt="Figure 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="744"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="752"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 3. MSCs promote endothelial tube formation… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 3. MSCs promote endothelial tube formation through IL-8 secretion </p> </strong> <div class="figure-caption-contents"><b> A. </b> HUVECs were cultured on…</div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 3. MSCs promote endothelial tube formation through IL-8 secretion </strong> <div class="figure-caption-contents"><b>A.</b> HUVECs were cultured on Matrigel in the presence of conditioned medium from CRC cells, CRC cell/MSC co-cultures or CRC cell/shIL-8-MSC co-cultures for 4 h. The images show the tube-formation ability of HUVECs in different conditioned media. Scale bar, 100 μm. <b>B.</b> Capillary-like structures were evaluated by quantifying tube lengths and numbers using the Angiogenesis Analyzer module in the ImageJ toolkit. The results are presented as the mean values per field from at least five randomly selected fields from three independent experiments (*, <i>p</i> < 0.05).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="figure-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/70fea993ddbd/oncotarget-06-42825-g004.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="742" data-image-height="779" data-image-alt="Figure 4" data-pmc-id="PMC4767474" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/ebe9f79b05a3/oncotarget-06-42825-g004.gif" alt="Figure 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="742"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="779"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 4. MSC-secreted IL-8 stimulates CRC cell… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 4. MSC-secreted IL-8 stimulates CRC cell proliferation </p> </strong> <div class="figure-caption-contents"><b> A. </b> The number of CRC cells (SW480,…</div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 4. MSC-secreted IL-8 stimulates CRC cell proliferation </strong> <div class="figure-caption-contents"><b>A.</b> The number of CRC cells (SW480, LS174T and HT29) following culture with fresh medium or conditioned medium from CRC cell/MSC co-cultures or CRC cell/shIL-8-MSC co-cultures was determined. The cell counts are presented as the mean values from three independent experiments using a hemocytometer (*, <i>p</i> < 0.05). <b>B.</b> Cultured CRC cells (SW480, LS174T and HT29) with conditioned medium indicated in (A) were immunostained for the proliferation marker Ki-67 and counterstained with the nuclear dye DAPI. Scale bar, 50 μm. <b>C.</b> The number of Ki-67–positive cells was counted, and the percentage of Ki-67–positive cells was calculated. The results are presented as the mean values per field from at least five randomly selected fields from three independent experiments (*, <i>p</i> < 0.05).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="figure-5"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/fd706c75767b/oncotarget-06-42825-g005.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="749" data-image-height="892" data-image-alt="Figure 5" data-pmc-id="PMC4767474" data-figure-id="F5"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba90/4767474/286b8d6ffed4/oncotarget-06-42825-g005.gif" alt="Figure 5" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="749"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="892"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 5. MSCs promote tumor angiogenesis and… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 5. MSCs promote tumor angiogenesis and growth <i> in vivo </i> </p> </strong> <div class="figure-caption-contents"><b> A. </b> A total of 2…</div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 5. MSCs promote tumor angiogenesis and growth <i>in vivo</i> </strong> <div class="figure-caption-contents"><b>A.</b> A total of 2 × 10<sup>6</sup> CRC cells (SW480, LS174T and HT29) alone or together with 2 × 10<sup>6</sup> MSCs or shIL-8-MSCs was injected into the flanks of nude athymic mice (<i>n</i> = 5). The tumors were harvested after 4 weeks and sectioned. The slides were stained with an anti-CD31 antibody for evaluating vessel morphology. Scale bar, 100 μm. <b>B.</b> MVD was determined by measuring the percentage of each field occupied by a CD31-positive signal. The vessel numbers per field were also counted. For each group, four randomly chosen high power fields per tumor (<i>n</i> = 5) were analyzed (*, <i>p</i> < 0.05). <b>C.</b> Total mRNA from tumor tissues was extracted, and the mRNA expression of IL-8, bFGF, VEGF and PDGF-BB in tumor tissues was measured by qRT-PCR (*, <i>p</i> < 0.05, **, <i>p</i> < 0.01). <b>D.</b> Male nude mice (4–6 weeks old) were injected with 2 × 10<sup>6</sup> CRC cells (SW480, LS174T and HT29) alone or together with 2 × 10<sup>6</sup> MSCs or shIL-8-MSCs (<i>n</i> = 5). The tumors were harvested after 4 weeks. Tumor volume was measured every week and calculated using the formula: tumor volume (mm<sup>3</sup>) = 0.5 × width<sup>2</sup> × length (*, <i>p</i> < 0.05, **, <i>p</i> < 0.01). <b>E.</b> Tumors were harvested and weighed after sacrifice (*, <i>p</i> < 0.05, **, <i>p</i> < 0.01). <b>F.</b> Paraffin-embedded tumor tissue sections from xenografts were analyzed by immunohistochemistry for the expression of the proliferation marker Ki-67. Scale bar, 100 μm. <b>G.</b> Immunohistochemistry staining was analyzed by counts of Ki-67–positive cells in random fields. The cell counts are presented as the mean values per field from at three representative fields at 400x magnification for each tumor (3 tumors per group; **, <i>p</i> < 0.01).</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/23763837/" ref="article_id=23763837&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="23763837" data-ga-label=""> Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Zhang T, Lee YW, Rui YF, Cheng TY, Jiang XH, Li G.</span> <span class="docsum-authors short-authors">Zhang T, et al.</span> <span class="docsum-journal-citation full-journal-citation">Stem Cell Res Ther. 2013 Jun 13;4(3):70. doi: 10.1186/scrt221.</span> <span class="docsum-journal-citation short-journal-citation">Stem Cell Res Ther. 2013.</span> <span class="citation-part">PMID: <span class="docsum-pmid">23763837</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/29590646/" ref="article_id=29590646&linksrc=similar_articles_link&ordinalpos=2" data-ga-category="similar_article" data-ga-action="29590646" data-ga-label=""> Human Glioblastoma-Derived Mesenchymal Stem Cell to Pericytes Transition and Angiogenic Capacity in Glioblastoma Microenvironment. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Yi D, Xiang W, Zhang Q, Cen Y, Su Q, Zhang F, Lu Y, Zhao H, Fu P.</span> <span class="docsum-authors short-authors">Yi D, et al.</span> <span class="docsum-journal-citation full-journal-citation">Cell Physiol Biochem. 2018;46(1):279-290. doi: 10.1159/000488429. 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aria-label="Toggle dropdown menu for keyword Research Support, Non-U.S. Gov't" tabindex="0" aria-controls="keyword-actions-publication-types-0" aria-expanded="false" data-pinger-ignore> Research Support, Non-U.S. Gov't </button><div id="keyword-actions-publication-types-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Research Support, Non-U.S. Gov't"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Research+Support%2C+Non-U.S.+Gov%27t%22%5Bpt%5D&sort=date&sort_order=desc" data-href="/?term=%22Research+Support%2C+Non-U.S.+Gov%27t%22%5Bpt%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Research Support, Non-U.S. Gov't"[pt]" data-ga-category="search" data-ga-action="pub_type" data-ga-label="Research Support, Non-U.S. Gov't"> Search in PubMed </a></li><li><a class="search-in-mesh-link 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dropdown menu for keyword Heterografts" tabindex="0" aria-controls="keyword-actions-mesh-terms-9" aria-expanded="false" data-pinger-ignore> Heterografts </button><div id="keyword-actions-mesh-terms-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Heterografts"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Heterografts%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Heterografts%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Heterografts"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Heterografts"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Heterografts" data-ga-category="search_mesh" data-ga-action="mesh_term_link" 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Immunohistochemistry </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Immunohistochemistry"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Immunohistochemistry%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Immunohistochemistry%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Immunohistochemistry"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Immunohistochemistry"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Immunohistochemistry" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Immunohistochemistry"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Immunohistochemistry"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Immunohistochemistry"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Interleukin-8 / metabolism*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-13" aria-expanded="false" data-pinger-ignore> Interleukin-8 / metabolism* </button><div id="keyword-actions-mesh-terms-major-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Interleukin-8 / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Interleukin-8%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Interleukin-8%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Interleukin-8/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Interleukin-8 / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Interleukin-8" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Interleukin-8 / metabolism*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Interleukin-8/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Interleukin-8/metabolism"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Mesenchymal Stem Cells / metabolism*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-14" aria-expanded="false" data-pinger-ignore> Mesenchymal Stem Cells / metabolism* </button><div id="keyword-actions-mesh-terms-major-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Mesenchymal Stem Cells / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Mesenchymal+Stem+Cells%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Mesenchymal+Stem+Cells%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Mesenchymal Stem Cells/metabolism"[MAJR]" data-ga-category="search" 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data-pinger-ignore> Mice </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Mice"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Mice"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Mice" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Mice"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Mice"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Mice"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Mice, Nude" tabindex="0" aria-controls="keyword-actions-mesh-terms-16" aria-expanded="false" data-pinger-ignore> Mice, Nude </button><div id="keyword-actions-mesh-terms-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Mice, Nude"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Mice%2C+Nude%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Mice%2C+Nude%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice, Nude"[MeSH]" 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Pathologic / metabolism* </button><div id="keyword-actions-mesh-terms-major-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Neovascularization, Pathologic / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Neovascularization%2C+Pathologic%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Neovascularization%2C+Pathologic%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Neovascularization, Pathologic/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Neovascularization, Pathologic / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Neovascularization%2C+Pathologic" 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Neovascularization, Pathologic / pathology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Neovascularization%2C+Pathologic%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Neovascularization%2C+Pathologic%2Fpathology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Neovascularization, Pathologic/pathology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Neovascularization, Pathologic / pathology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Neovascularization%2C+Pathologic" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Neovascularization, Pathologic / pathology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Neovascularization, Pathologic/pathology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Neovascularization, Pathologic/pathology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword RNA, Small Interfering" tabindex="0" aria-controls="keyword-actions-mesh-terms-19" aria-expanded="false" data-pinger-ignore> RNA, Small Interfering </button><div id="keyword-actions-mesh-terms-19" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword RNA, Small Interfering"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22RNA%2C+Small+Interfering%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22RNA%2C+Small+Interfering%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="RNA, Small Interfering"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="RNA, Small Interfering"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=RNA%2C+Small+Interfering" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="RNA, Small Interfering"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""RNA, Small Interfering"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""RNA, Small Interfering"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Reverse Transcriptase Polymerase Chain Reaction" tabindex="0" aria-controls="keyword-actions-mesh-terms-20" aria-expanded="false" data-pinger-ignore> Reverse Transcriptase Polymerase Chain Reaction </button><div id="keyword-actions-mesh-terms-20" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Reverse Transcriptase Polymerase Chain Reaction"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Reverse+Transcriptase+Polymerase+Chain+Reaction%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Reverse+Transcriptase+Polymerase+Chain+Reaction%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Reverse Transcriptase Polymerase Chain Reaction"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Reverse Transcriptase Polymerase Chain Reaction"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Reverse+Transcriptase+Polymerase+Chain+Reaction" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Reverse Transcriptase Polymerase Chain Reaction"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Reverse Transcriptase Polymerase Chain Reaction"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Reverse Transcriptase Polymerase Chain Reaction"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Transfection" tabindex="0" aria-controls="keyword-actions-mesh-terms-21" aria-expanded="false" data-pinger-ignore> Transfection </button><div id="keyword-actions-mesh-terms-21" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Transfection"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Transfection%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Transfection%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Transfection"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Transfection"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Transfection" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Transfection"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Transfection"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Transfection"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword CXCL8 protein, human" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> CXCL8 protein, human </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword CXCL8 protein, human"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22CXCL8+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22CXCL8+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="CXCL8 protein, human"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="CXCL8 protein, human"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22CXCL8+protein%2C+human%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="CXCL8 protein, human"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""CXCL8 protein, human"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""CXCL8 protein, human"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Culture Media, Conditioned" tabindex="0" aria-controls="keyword-actions-substances-1" aria-expanded="false" data-pinger-ignore> Culture Media, Conditioned </button><div id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Culture Media, Conditioned"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Culture+Media%2C+Conditioned%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Culture+Media%2C+Conditioned%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Culture Media, Conditioned"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Culture Media, Conditioned"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Culture+Media%2C+Conditioned%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Culture Media, Conditioned"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Culture Media, Conditioned"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Culture Media, Conditioned"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Interleukin-8" tabindex="0" aria-controls="keyword-actions-substances-2" aria-expanded="false" data-pinger-ignore> Interleukin-8 </button><div id="keyword-actions-substances-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Interleukin-8"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Interleukin-8%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Interleukin-8%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Interleukin-8"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Interleukin-8"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Interleukin-8%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Interleukin-8"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Interleukin-8"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Interleukin-8"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword RNA, Small Interfering" tabindex="0" aria-controls="keyword-actions-substances-3" aria-expanded="false" data-pinger-ignore> RNA, Small Interfering </button><div id="keyword-actions-substances-3" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword RNA, Small Interfering"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22RNA%2C+Small+Interfering%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22RNA%2C+Small+Interfering%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="RNA, Small Interfering"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="RNA, Small Interfering"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22RNA%2C+Small+Interfering%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="RNA, Small Interfering"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""RNA, Small Interfering"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""RNA, Small Interfering"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="related-links" class="related-links"> <h2 class="title"> Related information </h2> <ul class="related-links-list"><li><a title="Related PubChem Compound via MeSH" 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Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer - PubMed