Childhood Midline Tract Carcinoma Treatment

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return(false);">respiratory tract</a> is made up of the nose, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=439429&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000439429&version=patient&language=English&dictionary=Cancer.gov'); return(false);">throat</a>, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46026&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046026&version=patient&language=English&dictionary=Cancer.gov'); return(false);">larynx</a>, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46623&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046623&version=patient&language=English&dictionary=Cancer.gov'); return(false);">trachea</a>, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46493&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046493&version=patient&language=English&dictionary=Cancer.gov'); return(false);">bronchi</a>, and <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=270740&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000270740&version=patient&language=English&dictionary=Cancer.gov'); return(false);">lungs</a>. <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=790111&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000790111&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Midline tract carcinoma</a> may also form in other places along the middle of the body, such as the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46616&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046616&version=patient&language=English&dictionary=Cancer.gov'); return(false);">thymus</a>, the area between the lungs, the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46254&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046254&version=patient&language=English&dictionary=Cancer.gov'); return(false);">pancreas</a>, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46312&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046312&version=patient&language=English&dictionary=Cancer.gov'); return(false);">liver</a>, and <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46501&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046501&version=patient&language=English&dictionary=Cancer.gov'); return(false);">bladder</a>.<figure id="figure_1725" class="image-center"><a href="https://nci-media.cancer.gov/pdq/media/images/803493.jpg" target="_blank" class="article-image-enlarge">Enlarge</a><img id="_1725" alt="Drawing showing areas where NUT carcinoma may form, including the nose (nasal cavity), throat (pharynx), larynx, lung, thymus, trachea, bronchi, area between the lungs, liver, pancreas, and bladder." title="Drawing showing areas where NUT carcinoma may form, including the nose (nasal cavity), throat (pharynx), larynx, lung, thymus, trachea, bronchi, area between the lungs, liver, pancreas, and bladder." src="https://nci-media.cancer.gov/pdq/media/images/803493-750.jpg"><figcaption class="caption-container"><em class="gene-name">NUT</em> carcinoma is a rare type of cancer that forms in the respiratory tract or in other places along the middle of the body, including the thymus, the area between the lungs, and the liver, pancreas, and bladder. It usually grows and spreads quickly and cannot be cured. <em class="gene-name">NUT </em> carcinoma usually occurs in children and young adults.</figcaption></figure></p></section><section id="_1659"><h3 id="_1660" type="keypoint" do-not-show="toc">Midline tract carcinoma is sometimes caused by a change in the <em class="gene-name">NUT</em> gene.</h3><p id="_1661" tabindex="-1">Midline tract carcinoma is caused by a change in a <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46470&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046470&version=patient&language=English&dictionary=Cancer.gov'); return(false);">chromosome</a>. Every <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46476&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046476&version=patient&language=English&dictionary=Cancer.gov'); return(false);">cell</a> in the body contains <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45671&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045671&version=patient&language=English&dictionary=Cancer.gov'); return(false);">DNA</a> (<a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46391&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046391&version=patient&language=English&dictionary=Cancer.gov'); return(false);">genetic</a> material stored inside chromosomes) that controls how the cell looks and acts. Midline tract carcinoma may form when part of the DNA from chromosome 15 (called the <em class="gene-name"><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=791168&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000791168&version=patient&language=English&dictionary=Cancer.gov'); return(false);">NUT</a></em> <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45693&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045693&version=patient&language=English&dictionary=Cancer.gov'); return(false);">gene</a>) joins with the DNA from another chromosome.</p></section><section id="_1662"><h3 id="_1663" type="keypoint" do-not-show="toc">The signs and symptoms of midline tract carcinoma are not the same in every child.</h3><p id="_1664" tabindex="-1">The <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=750109&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000750109&version=patient&language=English&dictionary=Cancer.gov'); return(false);">signs</a> and <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45022&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045022&version=patient&language=English&dictionary=Cancer.gov'); return(false);">symptoms</a> of midline tract carcinoma depend on where the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45333&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045333&version=patient&language=English&dictionary=Cancer.gov'); return(false);">cancer</a> formed in the body.</p></section><section id="_1665"><h3 id="_1666" type="keypoint" do-not-show="toc">Tests that examine the body are used to help diagnose midline tract carcinoma.</h3><p id="_1667" tabindex="-1">The tests used to <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46450&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046450&version=patient&language=English&dictionary=Cancer.gov'); return(false);">diagnose</a> midline tract carcinoma depend on where the cancer formed in the body and may include the following:</p><div class="pdq-content-list"><ul id="_1668"><li><strong><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=270871&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000270871&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Physical exam</a> and <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=798522&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000798522&version=patient&language=English&dictionary=Cancer.gov'); return(false);">health history</a></strong>: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.</li><li><strong><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=304687&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000304687&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Chest x-ray</a></strong>: An <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45944&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045944&version=patient&language=English&dictionary=Cancer.gov'); return(false);">x-ray</a> of the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.</li><li><strong><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45788&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045788&version=patient&language=English&dictionary=Cancer.gov'); return(false);">MRI </a>(magnetic resonance imaging)</strong>: A procedure that uses a magnet, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=651209&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000651209&version=patient&language=English&dictionary=Cancer.gov'); return(false);">radio waves</a>, and a computer to make a series of detailed pictures of areas of the body, such as the head and neck. This procedure is also called nuclear magnetic resonance imaging (NMRI).</li><li><strong><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46033&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046033&version=patient&language=English&dictionary=Cancer.gov'); return(false);">CT scan</a> (CAT scan)</strong>: A procedure that makes a series of detailed pictures of areas inside the body taken from different angles. The pictures are made by a computer linked to an x-ray machine. A <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=409764&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000409764&version=patient&language=English&dictionary=Cancer.gov'); return(false);">dye</a> may be <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44678&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044678&version=patient&language=English&dictionary=Cancer.gov'); return(false);">injected</a> into a <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=476471&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000476471&version=patient&language=English&dictionary=Cancer.gov'); return(false);">vein</a> or swallowed to help the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=257523&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000257523&version=patient&language=English&dictionary=Cancer.gov'); return(false);">organs</a> or <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46683&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046683&version=patient&language=English&dictionary=Cancer.gov'); return(false);">tissues</a> show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.<figure id="figure_1654" class="image-center"><a href="https://nci-media.cancer.gov/pdq/media/images/775452.jpg" target="_blank" class="article-image-enlarge">Enlarge</a><img id="_1654" alt="Computed tomography (CT) scan of the head and neck; drawing shows a child lying on a table that slides through the CT scanner, which takes a series of detailed x-ray pictures of the inside of the head and neck." title="Computed tomography (CT) scan of the head and neck; drawing shows a child lying on a table that slides through the CT scanner, which takes a series of detailed x-ray pictures of the inside of the head and neck." src="https://nci-media.cancer.gov/pdq/media/images/775452-750.jpg"><figcaption class="caption-container">Computed tomography (CT) scan of the head and neck. The child lies on a table that slides through the CT scanner, which takes a series of detailed x-ray pictures of the inside of the head and neck. </figcaption></figure></li><li><strong><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45164&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045164&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Biopsy</a></strong>: The removal of cells so they can be viewed under a <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=638184&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000638184&version=patient&language=English&dictionary=Cancer.gov'); return(false);">microscope</a> by a <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46244&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046244&version=patient&language=English&dictionary=Cancer.gov'); return(false);">pathologist</a> to check for signs of cancer. <p id="_1577" tabindex="-1">The following tests may be done on the sample of cells that was removed:</p><div class="pdq-content-list"><ul id="_1578" class="list-dash"><li><strong><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=653117&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000653117&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Immunohistochemistry</a></strong>: A <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46590&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046590&version=patient&language=English&dictionary=Cancer.gov'); return(false);">laboratory test</a> that uses <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44918&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044918&version=patient&language=English&dictionary=Cancer.gov'); return(false);">antibodies</a> to check for certain <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46086&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046086&version=patient&language=English&dictionary=Cancer.gov'); return(false);">antigens</a> (<a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45776&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045776&version=patient&language=English&dictionary=Cancer.gov'); return(false);">markers</a>) in a sample of a patient’s tissue. The antibodies are usually linked to an <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46081&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046081&version=patient&language=English&dictionary=Cancer.gov'); return(false);">enzyme</a> or a fluorescent dye. After the antibodies bind to a specific antigen in the tissue sample, the enzyme or dye is activated, and the antigen can then be seen under a microscope. This type of test is used to help diagnose cancer and to help tell one type of cancer from another type of cancer.</li><li><strong><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=270737&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000270737&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Cytogenetic</a> <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=390238&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000390238&version=patient&language=English&dictionary=Cancer.gov'); return(false);">analysis</a></strong>: A laboratory test in which the chromosomes of cells in a sample of <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45622&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045622&version=patient&language=English&dictionary=Cancer.gov'); return(false);">bone marrow</a>, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=270735&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000270735&version=patient&language=English&dictionary=Cancer.gov'); return(false);">blood</a>, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46634&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046634&version=patient&language=English&dictionary=Cancer.gov'); return(false);">tumor</a>, or other tissue are counted and checked for any changes, such as broken, missing, rearranged, or extra chromosomes. Changes in certain chromosomes may be a sign of cancer. Cytogenetic analysis is used to help diagnose cancer, plan treatment, or find out how well treatment is working. Other tests, such as <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=460151&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000460151&version=patient&language=English&dictionary=Cancer.gov'); return(false);">fluorescence in situ hybridization</a> (FISH), may also be done to look for certain changes in the chromosomes.</li></ul></div></li></ul></div></section><section id="_1669"><h3 id="_1670" type="keypoint" do-not-show="toc">Midline tract carcinoma grows and spreads quickly.</h3><p id="_1671" tabindex="-1">Midline tract carcinoma with <em class="gene-name">NUT</em> gene changes is an <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46053&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046053&version=patient&language=English&dictionary=Cancer.gov'); return(false);">aggressive</a> cancer that cannot be <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=318813&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000318813&version=patient&language=English&dictionary=Cancer.gov'); return(false);">cured</a>.</p></section></div> </section> <section id="_1710"> <h2>Stages of Childhood Midline Tract Carcinoma</h2> <div id="_section_1710" class="pdq-sections"><p id="_1711" tabindex="-1">The process used to find out if <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45333&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045333&version=patient&language=English&dictionary=Cancer.gov'); return(false);">cancer</a> has spread from where it first began to nearby areas or to other parts of the body is called <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46597&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046597&version=patient&language=English&dictionary=Cancer.gov'); return(false);">staging</a>. There is no standard <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=689095&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000689095&version=patient&language=English&dictionary=Cancer.gov'); return(false);">staging system</a> for childhood <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=790111&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000790111&version=patient&language=English&dictionary=Cancer.gov'); return(false);">midline tract carcinoma</a>. The results of the <a href="/types/midline/patient-child-midline-tract-carcinoma-treatment-pdq#_1666">tests and procedures</a> done to <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46450&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046450&version=patient&language=English&dictionary=Cancer.gov'); return(false);">diagnose</a> midline tract carcinoma are used to help make decisions about treatment.</p><p id="_1716" tabindex="-1">Childhood midline tract carcinoma may spread to the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45762&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045762&version=patient&language=English&dictionary=Cancer.gov'); return(false);">lymph nodes</a>, the lining around the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=270740&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000270740&version=patient&language=English&dictionary=Cancer.gov'); return(false);">lung</a>, <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45622&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045622&version=patient&language=English&dictionary=Cancer.gov'); return(false);">bone marrow</a>, or bone. </p></div> </section> <section id="_1672"> <h2>Treatment Option Overview</h2> <div id="_section_1672" class="pdq-sections"><div class="key-points"><h3 id="_1672_kpBoxHdr" do-not-show="toc">Key Points</h3><div id="_kp_section_1672_3"><ul><li>There are different types of treatment for children with midline tract carcinoma.</li><li>Children with midline tract carcinoma should have their treatment planned by a team of doctors who are experts in treating childhood cancer.</li><li>Three types of treatment are used:<ul><li>Surgery</li><li>Radiation therapy</li><li>Chemotherapy</li></ul></li><li>New types of treatment are being tested in clinical trials.<ul><li>Targeted therapy</li></ul></li><li>Treatment for childhood midline tract carcinoma may cause side effects.</li><li>Patients may want to think about taking part in a clinical trial.</li><li>Patients can enter clinical trials before, during, or after starting their cancer treatment.</li><li>Follow-up tests may be needed.</li></ul></div></div><section id="_1673"><h3 id="_1674" type="keypoint" do-not-show="toc">There are different types of treatment for children with midline tract carcinoma.</h3><p id="_1673_md_79" tabindex="-1">Some treatments are <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44930&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044930&version=patient&language=English&dictionary=Cancer.gov'); return(false);">standard</a> (the currently used treatment), and some are being tested in <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45961&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045961&version=patient&language=English&dictionary=Cancer.gov'); return(false);">clinical trials</a>. A treatment clinical trial is a <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=651211&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000651211&version=patient&language=English&dictionary=Cancer.gov'); return(false);">research study</a> meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.</p><p id="_1673_md_80" tabindex="-1">Because cancer in children is rare, taking part in a clinical trial should be considered. Some clinical trials are open only to patients who have not started treatment.</p></section><section id="_1675"><h3 id="_1676" type="keypoint" do-not-show="toc">Children with midline tract carcinoma should have their treatment planned by a team of doctors who are experts in treating childhood cancer.</h3><p id="_1675_md_83" tabindex="-1">A pediatric oncologist, a doctor who specializes in treating children with cancer, oversees treatment for cancer. The pediatric oncologist works with other health care providers who are experts in treating children with cancer and also specialize in other areas of medicine. Other specialists may include:</p><div class="pdq-content-list"><ul id="_1675_md_84"><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=757278&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000757278&version=patient&language=English&dictionary=Cancer.gov'); return(false);">pediatrician</a></li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=318823&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000318823&version=patient&language=English&dictionary=Cancer.gov'); return(false);">pediatric surgeon</a></li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46546&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046546&version=patient&language=English&dictionary=Cancer.gov'); return(false);">radiation oncologist</a></li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46244&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046244&version=patient&language=English&dictionary=Cancer.gov'); return(false);">pathologist</a></li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=318821&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000318821&version=patient&language=English&dictionary=Cancer.gov'); return(false);">pediatric nurse specialist</a></li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44730&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044730&version=patient&language=English&dictionary=Cancer.gov'); return(false);">social worker</a></li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=318825&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000318825&version=patient&language=English&dictionary=Cancer.gov'); return(false);">rehabilitation specialist</a></li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44716&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044716&version=patient&language=English&dictionary=Cancer.gov'); return(false);">psychologist</a></li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=690737&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000690737&version=patient&language=English&dictionary=Cancer.gov'); return(false);">child-life specialist</a></li></ul></div></section><section id="_1677"><h3 id="_1678" type="keypoint" do-not-show="toc">Three types of treatment are used:</h3><section id="_1679"><h4 id="_1680" type="keypoint" do-not-show="toc">Surgery</h4><p id="_1681" tabindex="-1"><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45570&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045570&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Surgery</a> to remove the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46634&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046634&version=patient&language=English&dictionary=Cancer.gov'); return(false);">tumor</a> is one of the main treatments used for childhood <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=790111&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000790111&version=patient&language=English&dictionary=Cancer.gov'); return(false);">midline tract carcinoma</a>.</p></section><section id="_1683"><h4 id="_1684" type="keypoint" do-not-show="toc">Radiation therapy</h4><p id="_1685" tabindex="-1"><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44971&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044971&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Radiation therapy</a> is a <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45333&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045333&version=patient&language=English&dictionary=Cancer.gov'); return(false);">cancer</a> treatment that uses high-energy <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45944&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045944&version=patient&language=English&dictionary=Cancer.gov'); return(false);">x-rays</a> or other types of <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45072&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045072&version=patient&language=English&dictionary=Cancer.gov'); return(false);">radiation</a> to kill cancer <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46476&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046476&version=patient&language=English&dictionary=Cancer.gov'); return(false);">cells</a> or keep them from growing. <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46686&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046686&version=patient&language=English&dictionary=Cancer.gov'); return(false);">External radiation therapy</a> uses a machine outside the body to send radiation toward the area of the body with cancer.</p></section><section id="_1686"><h4 id="_1687" type="keypoint" do-not-show="toc">Chemotherapy</h4><p id="_1688" tabindex="-1"><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45214&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045214&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Chemotherapy</a> is a cancer treatment that uses <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=348921&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000348921&version=patient&language=English&dictionary=Cancer.gov'); return(false);">drugs</a> to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44678&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044678&version=patient&language=English&dictionary=Cancer.gov'); return(false);">injected</a> into a <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=476471&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000476471&version=patient&language=English&dictionary=Cancer.gov'); return(false);">vein</a> or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (<a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=301626&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000301626&version=patient&language=English&dictionary=Cancer.gov'); return(false);">systemic chemotherapy</a>).</p></section></section><section id="_1689"><h3 id="_1690" type="keypoint" do-not-show="toc">New types of treatment are being tested in clinical trials.</h3><p id="_1691" tabindex="-1">This summary section describes treatments that are being studied in <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45961&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045961&version=patient&language=English&dictionary=Cancer.gov'); return(false);">clinical trials</a>. It may not mention every new treatment being studied. Information about clinical trials is available from the <a href="https://www.cancer.gov/research/participate/clinical-trials" title="https://www.cancer.gov/research/participate/clinical-trials">NCI website</a>.</p><section id="_1692"><h4 id="_1693" type="keypoint" do-not-show="toc">Targeted therapy</h4><p id="_1694" tabindex="-1"><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=270742&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000270742&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Targeted therapy</a> is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells. Targeted therapies usually cause less harm to normal cells than chemotherapy or radiation therapy do. New targeted therapy drugs that stop cancer cells from growing are being studied to treat midline tract carcinoma.</p></section></section><section id="_1707"><h3 id="_1708" type="keypoint" do-not-show="toc">Treatment for childhood midline tract carcinoma may cause side effects.</h3><p id="_1707_md_76" tabindex="-1">To learn more about <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46580&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046580&version=patient&language=English&dictionary=Cancer.gov'); return(false);">side effects</a> that begin during treatment for cancer, visit <a href="https://www.cancer.gov/about-cancer/treatment/side-effects" title="https://www.cancer.gov/about-cancer/treatment/side-effects">Side Effects</a>.</p></section><section id="_1695"><h3 id="_1696" type="keypoint" do-not-show="toc">Patients may want to think about taking part in a clinical trial.</h3><p id="_1695_md_23" tabindex="-1">For some patients, taking part in a <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45961&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045961&version=patient&language=English&dictionary=Cancer.gov'); return(false);">clinical trial</a> may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44930&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044930&version=patient&language=English&dictionary=Cancer.gov'); return(false);">standard treatment</a>.</p><p id="_1695_md_24" tabindex="-1">Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.</p><p id="_1695_md_25" tabindex="-1">Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.</p></section><section id="_1697"><h3 id="_1698" type="keypoint" do-not-show="toc">Patients can enter clinical trials before, during, or after starting their cancer treatment.</h3><p id="_1697_md_29" tabindex="-1">Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46580&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046580&version=patient&language=English&dictionary=Cancer.gov'); return(false);">side effects</a> of cancer treatment.</p><p id="_1697_md_30" tabindex="-1">Clinical trials are taking place in many parts of the country. Information about clinical trials supported by NCI can be found on NCI’s <a href="https://www.cancer.gov/research/participate/clinical-trials-search" title="https://www.cancer.gov/research/participate/clinical-trials-search">clinical trials search</a> webpage. Clinical trials supported by other organizations can be found on the <a href="https://clinicaltrials.gov/" title="https://clinicaltrials.gov/">ClinicalTrials.gov</a> website.</p></section><section id="_1699"><h3 id="_1700" type="keypoint" do-not-show="toc">Follow-up tests may be needed.</h3><p id="_1699_md_55" tabindex="-1">As your child goes through treatment, they will have follow-up tests or check-ups. Some tests that were done to <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46450&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046450&version=patient&language=English&dictionary=Cancer.gov'); return(false);">diagnose</a> or <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45885&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045885&version=patient&language=English&dictionary=Cancer.gov'); return(false);">stage</a> the cancer may be repeated to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.</p><p id="_1699_md_56" tabindex="-1">Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your child's condition has changed or if the cancer has recurred (come back). </p></section></div> </section> <section id="_1717"> <h2>Treatment of Childhood Midline Tract Carcinoma</h2> <div id="_section_1717" class="pdq-sections"><p id="_1718" tabindex="-1">For information about the treatments listed below, see the <a href="/types/midline/patient-child-midline-tract-carcinoma-treatment-pdq#_1677">Treatment Option Overview</a> section.</p><p id="_1719" tabindex="-1">There is no <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44930&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044930&version=patient&language=English&dictionary=Cancer.gov'); return(false);">standard treatment</a> for newly <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46450&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046450&version=patient&language=English&dictionary=Cancer.gov'); return(false);">diagnosed</a> <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=790111&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000790111&version=patient&language=English&dictionary=Cancer.gov'); return(false);">midline tract carcinoma</a> with <em class="gene-name"><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=791168&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000791168&version=patient&language=English&dictionary=Cancer.gov'); return(false);">NUT</a></em> <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45693&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045693&version=patient&language=English&dictionary=Cancer.gov'); return(false);">gene</a> changes. Treatment may include the following:</p><div class="pdq-content-list"><ul id="_1720"><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45570&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045570&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Surgery</a> to remove the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46634&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046634&version=patient&language=English&dictionary=Cancer.gov'); return(false);">tumor</a>.</li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46686&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046686&version=patient&language=English&dictionary=Cancer.gov'); return(false);">External radiation therapy</a>.</li><li><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45214&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045214&version=patient&language=English&dictionary=Cancer.gov'); return(false);">Chemotherapy</a>.</li></ul></div><p id="_TrialSearch_1717_19" tabindex="-1">Use our <a href="https://www.cancer.gov/research/participate/clinical-trials-search" title="https://www.cancer.gov/research/participate/clinical-trials-search">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/research/participate/clinical-trials" title="https://www.cancer.gov/research/participate/clinical-trials">General information</a> about clinical trials is also available.</p></div> </section> <section id="_1721"> <h2>Treatment of Recurrent Childhood Midline Tract Carcinoma</h2> <div id="_section_1721" class="pdq-sections"><p id="_1722" tabindex="-1">For information about the treatments listed below, see the <a href="/types/midline/patient-child-midline-tract-carcinoma-treatment-pdq#_1677">Treatment Option Overview</a> section.</p><p id="_1723" tabindex="-1">Treatment of <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45862&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045862&version=patient&language=English&dictionary=Cancer.gov'); return(false);">recurrent</a> <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=790111&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000790111&version=patient&language=English&dictionary=Cancer.gov'); return(false);">midline tract carcinoma</a> with <em class="gene-name"><a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=791168&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000791168&version=patient&language=English&dictionary=Cancer.gov'); return(false);">NUT</a></em> <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45693&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045693&version=patient&language=English&dictionary=Cancer.gov'); return(false);">gene</a> changes may include the following:</p><div class="pdq-content-list"><ul id="_1724"><li>A <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=45961&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000045961&version=patient&language=English&dictionary=Cancer.gov'); return(false);">clinical trial</a> that checks a sample of the patient's <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=46634&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000046634&version=patient&language=English&dictionary=Cancer.gov'); return(false);">tumor</a> for certain gene changes. The type of <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=270742&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000270742&version=patient&language=English&dictionary=Cancer.gov'); return(false);">targeted therapy</a> that will be given to the patient depends on the type of gene change.</li><li>A clinical trial that is testing a new group of drugs called BET bromodomain inhibitors in younger patients.</li></ul></div><p id="_TrialSearch_1721_19" tabindex="-1">Use our <a href="https://www.cancer.gov/research/participate/clinical-trials-search" title="https://www.cancer.gov/research/participate/clinical-trials-search">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/research/participate/clinical-trials" title="https://www.cancer.gov/research/participate/clinical-trials">General information</a> about clinical trials is also available.</p></div> </section> <section id="_1704"> <h2>To Learn More About Childhood Midline Tract Carcinoma</h2> <div id="_section_1704" class="pdq-sections"><p id="_1705" tabindex="-1">For more information from the <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=44266&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000044266&version=patient&language=English&dictionary=Cancer.gov'); return(false);">National Cancer Institute</a> about <a class="definition" type="GlossaryTermRefs" href="/Common/PopUps/popDefinition.aspx?id=790111&version=patient&language=English&dictionary=Cancer.gov" onclick="javascript:popWindow('defbyid','CDR0000790111&version=patient&language=English&dictionary=Cancer.gov'); return(false);">midline tract carcinoma</a>, see the following:</p><div class="pdq-content-list"><ul id="_1706"><li><a href="https://www.cancer.gov/types/head-and-neck" title="https://www.cancer.gov/types/head-and-neck">Head and Neck Cancer Home Page</a></li><li><a href="https://www.cancer.gov/about-cancer/diagnosis-staging/ct-scans-fact-sheet" title="https://www.cancer.gov/about-cancer/diagnosis-staging/ct-scans-fact-sheet">Computed Tomography (CT) Scans and Cancer</a></li><li><a href="https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies" title="https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies">Targeted Cancer Therapies</a></li></ul></div><p id="_1704_md_44" tabindex="-1">For more childhood cancer information and other general cancer resources, visit:</p><div class="pdq-content-list"><ul id="_1704_md_45"><li><a href="https://www.cancer.gov/about-cancer" title="https://www.cancer.gov/about-cancer">About Cancer</a></li><li><a href="https://www.cancer.gov/types/childhood-cancers" title="https://www.cancer.gov/types/childhood-cancers">Childhood Cancers</a> </li><li><a href="http://www.curesearch.org/" title="http://www.curesearch.org/">CureSearch for Children's Cancer</a> </li><li><a href="/types/childhood-cancers/late-effects-pdq">Late Effects of Treatment for Childhood Cancer</a></li><li><a href="https://www.cancer.gov/types/aya" title="https://www.cancer.gov/types/aya">Adolescents and Young Adults with Cancer</a></li><li><a href="https://www.cancer.gov/publications/patient-education/guide-for-parents" title="https://www.cancer.gov/publications/patient-education/guide-for-parents">Children with Cancer: A Guide for Parents</a></li><li><a href="https://www.cancer.gov/types/childhood-cancers/child-adolescent-cancers-fact-sheet" title="https://www.cancer.gov/types/childhood-cancers/child-adolescent-cancers-fact-sheet">Cancer in Children and Adolescents</a></li><li><a href="https://www.cancer.gov/about-cancer/diagnosis-staging/staging" title="https://www.cancer.gov/about-cancer/diagnosis-staging/staging">Staging</a></li><li><a href="https://www.cancer.gov/about-cancer/coping" title="https://www.cancer.gov/about-cancer/coping">Coping with Cancer</a></li><li><a href="https://www.cancer.gov/about-cancer/coping/questions" title="https://www.cancer.gov/about-cancer/coping/questions">Questions to Ask Your Doctor about Cancer</a></li><li><a href="https://cancercontrol.cancer.gov/ocs/resources/survivors.html" title="https://cancercontrol.cancer.gov/ocs/resources/survivors.html">For Survivors and Caregivers</a> </li></ul></div></div> </section> <section id="_AboutThis_1"> <h2>About This PDQ Summary</h2> <div id="_section_AboutThis_1" class="pdq-sections"><section id="_AboutThis_2"><h3 id="_AboutThis_2_toc">About PDQ</h3><p id="_AboutThis_3" tabindex="-1">Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in <a href="https://www.cancer.gov/espanol/publicaciones/pdq" title="https://www.cancer.gov/espanol/publicaciones/pdq">Spanish</a>.</p><p id="_AboutThis_4" tabindex="-1">PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.</p></section><section id="_AboutThis_5"><h3 id="_AboutThis_5_toc">Purpose of This Summary</h3><p id="_AboutThis_6" tabindex="-1">This PDQ cancer information summary has current information about the treatment of childhood midline tract carcinoma. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p></section><section id="_AboutThis_7"><h3 id="_AboutThis_7_toc">Reviewers and Updates</h3><p id="_AboutThis_8" tabindex="-1">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change. </p><p id="_AboutThis_9" tabindex="-1">The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the <a href="https://www.cancer.gov/publications/pdq/editorial-boards/pediatric-treatment" title="https://www.cancer.gov/publications/pdq/editorial-boards/pediatric-treatment">PDQ Pediatric Treatment Editorial Board</a>. </p></section><section id="_AboutThis_10"><h3 id="_AboutThis_10_toc">Clinical Trial Information</h3><p id="_AboutThis_11" tabindex="-1">A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment. </p><p id="_AboutThis_12" tabindex="-1">Clinical trials can be found online at <a href="https://www.cancer.gov/research/participate/clinical-trials" title="https://www.cancer.gov/research/participate/clinical-trials">NCI's website</a>. For more information, call the <a href="https://www.cancer.gov/contact/contact-center" title="https://www.cancer.gov/contact/contact-center">Cancer Information Service</a> (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237). </p></section><section id="_AboutThis_13"><h3 id="_AboutThis_13_toc">Permission to Use This Summary</h3><p id="_AboutThis_14" tabindex="-1">PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].” </p><p id="_AboutThis_15" tabindex="-1">The best way to cite this PDQ summary is:</p><p id="_AboutThis_21" tabindex="-1">PDQ® Pediatric Treatment Editorial Board. PDQ Childhood Midline Tract Carcinoma with NUT Gene Changes Treatment. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: <a href="https://www.cancer.gov/types/midline/patient-child-midline-tract-carcinoma-treatment-pdq" title="https://www.cancer.gov/types/midline/patient-child-midline-tract-carcinoma-treatment-pdq">https://www.cancer.gov/types/midline/patient-child-midline-tract-carcinoma-treatment-pdq</a>. Accessed <MM/DD/YYYY>. </p><p id="_AboutThis_16" tabindex="-1">Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in <a href="https://visualsonline.cancer.gov/" title="https://visualsonline.cancer.gov/">Visuals Online</a>. Visuals Online is a collection of more than 3,000 scientific images. </p></section><section id="_AboutThis_17"><h3 id="_AboutThis_17_toc">Disclaimer</h3><p id="_AboutThis_18" tabindex="-1">The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the <a href="https://www.cancer.gov/about-cancer/managing-care" title="https://www.cancer.gov/about-cancer/managing-care">Managing Cancer Care</a> page.</p></section><section id="_AboutThis_19"><h3 id="_AboutThis_19_toc">Contact Us</h3><p id="_AboutThis_20" tabindex="-1">More information about contacting us or receiving help with the Cancer.gov website can be found on our <a href="https://www.cancer.gov/contact" title="https://www.cancer.gov/contact">Contact Us for Help</a> page. 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