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Materials and methods: To investigate the apoptosis mechanism, we isolated dentatin (DTN) from this plant using a bioassay-guided approach. DTN-induced cytotoxicity was observed with the MTT assay. Acridine orange/propidium iodide staining was used to detect cells in early apoptosis and high content screening (HCS) to observe nuclear condensation, cell permeability, mitochondrial membrane potential (MMP) and cytochrome c release. Apoptosis was confirmed with a clonogenic assay, DNA laddering and caspase 3/7 and 9 assays. Reactive oxygen species (ROS) formation, Bcl-2 and Bax expression, and cell cycle arrest were also investigated. The involvement of nuclear factor-kappa B (NF-kB) was analysed with the HCS assay. Results: A significant increase in chromatin condensation in the cell nucleus was observed by fluorescence analysis. Apoptosis was confirmed by the reduced number of colonies in the clonogenic assay and the increased number of cellular DNA breaks in treated cells observed as a DNA ladder. Treatment of MCF-7 cells with DTN encouraged apoptosis with cell death-transducing signals that reduced MMP by down-regulation of Bcl-2 and up-regulation of Bax, triggering cytochrome c release from the mitochondria to the cytosol. The released cytochrome c triggered the activation of caspase 9 followed by the executioner caspase 3/7. DTN treatment significantly arrested MCF-7 cells at the G0/G1 phase (po0.05) and ROS was significantly elevated. Moreover, DTN significantly blocked the induced translocation of NF-kB from cytoplasm to nucleus. Conclusion: Together, the results demonstrated that the DTN isolated from Clausena excavata inhibited the proliferation of MCF-7 cells, leading to cell cycle arrest and programmed cell death, which was confirmed to occur through the mitochondrial pathway with involvement of the NF-kB signalling pathway.","publication_date":"2013,,","grobid_abstract_attachment_id":"51085018"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [58370766]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":51085018,"attachmentType":"pdf"}"><img alt="First page of “Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/51085018/mini_magick20190126-6242-kpd8su.png?1548534071" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="58370766" href="https://independent.academia.edu/MohdSukari"><img alt="Profile image of Mohd Sukari" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Mohd Sukari</a></div><p class="ds-work-card--detail ds2-5-body-sm">2013</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":51085018,"attachmentType":"pdf","workUrl":"https://www.academia.edu/30641173/Dentatin_isolated_from_Clausena_excavata_induces_apoptosis_in_MCF_7_cellsthrough_the_intrinsic_pathway_with_involvement_of_NF_kB_signalling_andG0_G1_cell_cycle_arrest_a_bioassay_guided_approach"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":51085018,"attachmentType":"pdf","workUrl":"https://www.academia.edu/30641173/Dentatin_isolated_from_Clausena_excavata_induces_apoptosis_in_MCF_7_cellsthrough_the_intrinsic_pathway_with_involvement_of_NF_kB_signalling_andG0_G1_cell_cycle_arrest_a_bioassay_guided_approach"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="51085018" data-landing_url="https://www.academia.edu/30641173/Dentatin_isolated_from_Clausena_excavata_induces_apoptosis_in_MCF_7_cellsthrough_the_intrinsic_pathway_with_involvement_of_NF_kB_signalling_andG0_G1_cell_cycle_arrest_a_bioassay_guided_approach" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="30641150" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30641150/Dentatin_from_Clausena_excavata_Induces_Apoptosis_in_HepG2_Cells_via_Mitochondrial_Mediated_Signaling">Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58370766" href="https://independent.academia.edu/MohdSukari">Mohd Sukari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Asian Pacific journal of cancer prevention : APJCP, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Hepatocellular carcinoma (HCC) is a primary liver cancer with high global incidence and mortality rates. Current candidate drugs to treat HCC remain lacking and those in use possess undesirable side effects. In this investigation, the antiproliferative effects of dentatin (DTN), a natural coumarin, were evaluated on HepG2 cells and DTN&#39;s probable preliminary molecular mechanisms in apoptosis induction were further investigated. DTN significantly (p&lt;0.05) suppressed proliferation of HepG2 cells with an IC50 value of 12.0 μg/mL, without affecting human normal liver cells, WRL-68 (IC50&gt; 50 μg/mL) causing G0/G1 cell cycle arrest via apoptosis induction. Caspase colorimetric assays showed markedly increased levels of caspase-3 and caspase-9 activities throughout the treatment period. Western blotting of treated HepG2 cells revealed inhibition of NF-κB that triggers the mitochondrial-mediated apoptotic signaling pathway by up-regulating cytoplasmic cytochrome c and Bax, and down...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling","attachmentId":51085006,"attachmentType":"pdf","work_url":"https://www.academia.edu/30641150/Dentatin_from_Clausena_excavata_Induces_Apoptosis_in_HepG2_Cells_via_Mitochondrial_Mediated_Signaling","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/30641150/Dentatin_from_Clausena_excavata_Induces_Apoptosis_in_HepG2_Cells_via_Mitochondrial_Mediated_Signaling"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="11750051" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/11750051/_and_alpha_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_and_kappa_B_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo">&alpha;-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-&kappa;B and Hsp70 protein modulation in vitro, and tumor reduction in vivo</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="28852143" href="https://teknologimalaysia.academia.edu/MaizatulYahayu">Maizatul Yahayu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Drug Design, Development and Therapy, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"\u0026alpha;-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-\u0026kappa;B and Hsp70 protein modulation in vitro, and tumor reduction in vivo","attachmentId":46545980,"attachmentType":"pdf","work_url":"https://www.academia.edu/11750051/_and_alpha_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_and_kappa_B_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/11750051/_and_alpha_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_and_kappa_B_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="24371949" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24371949/Dentatin_from_Clausena_excavata_induces_apoptosis_and_reduces_the_tumors_size_of_LA_7_induced_mammary_carcinogenesis_in_Sprague_Dawley_rats">Dentatin from Clausena excavata induces apoptosis and reduces the tumors size of LA- 7 induced mammary carcinogenesis in Sprague Dawley rats</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="13425210" href="https://independent.academia.edu/NorrakiahAbdullahSani">Norrakiah Abdullah Sani</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dentatin from Clausena excavata induces apoptosis and reduces the tumors size of LA- 7 induced mammary carcinogenesis in Sprague Dawley rats","attachmentId":44703147,"attachmentType":"pdf","work_url":"https://www.academia.edu/24371949/Dentatin_from_Clausena_excavata_induces_apoptosis_and_reduces_the_tumors_size_of_LA_7_induced_mammary_carcinogenesis_in_Sprague_Dawley_rats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24371949/Dentatin_from_Clausena_excavata_induces_apoptosis_and_reduces_the_tumors_size_of_LA_7_induced_mammary_carcinogenesis_in_Sprague_Dawley_rats"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="47961134" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/47961134/Clausenidin_induces_caspase_dependent_apoptosis_in_colon_cancer">Clausenidin induces caspase-dependent apoptosis in colon cancer</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="188224614" href="https://independent.academia.edu/imaobongetti">imaobong etti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC complementary and alternative medicine, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Clausena excavata Burm.f. is a shrub traditionally used to treat cancer patients in Asia. The main bioactive chemical components of the plant are alkaloids and coumarins. In this study, we isolated clausenidin from the roots of C. excavata to determine its apoptotic effect on the colon cancer (HT-29) cell line. We examined the effect of clausenidin on cell viability, ROS generation, DNA fragmentation, mitochondrial membrane potential in HT-29 cells. Ultrastructural analysis was conducted for morphological evidence of apoptosis in the treated HT-29 cells. In addition, we also evaluated the effect of clausenidin treatment on the expression of caspase 3 and 9 genes and proteins in HT-29 cells. Clausenidin induced a G0/G1 cell cycle arrest in HT-29 cells with significant (p &lt; 0.05) dose-dependent increase in apoptotic cell population. The DNA fragmentation assay also showed apoptotic features in the clausenidin-treated HT-29 cells. Clausenidin treatment had caused significant (p &lt;...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Clausenidin induces caspase-dependent apoptosis in colon cancer","attachmentId":66821377,"attachmentType":"pdf","work_url":"https://www.academia.edu/47961134/Clausenidin_induces_caspase_dependent_apoptosis_in_colon_cancer","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/47961134/Clausenidin_induces_caspase_dependent_apoptosis_in_colon_cancer"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="38031688" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/38031688/A_Traditional_Poly_Herbal_Drug_Induced_Apoptosis_via_Caspase_3_Mediated_Pathway_in_RD_Cells_but_Caspase_3_Independent_Pathway_in_MCF_7_Cells">A Traditional Poly Herbal Drug Induced Apoptosis via Caspase 3 Mediated Pathway in RD Cells but Caspase 3 Independent Pathway in MCF-7 Cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="95758512" href="https://independent.academia.edu/InnovationInfo">Innovationinfo Publishing</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Asian Journal of Ethnopharmacology and Medicinal Foods, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Research on anticancer drugs focuses on agents that induce cell death in cancer cells leaving healthy cells unaffected. Our previous findings proved that a poly herbal formulation, Le Pana Guliya (LPG) has beneficial potential as an anti-proliferative and anticancer agent. The aim of the study is to evaluate anticancer activity of LPG against Human Rhabdomyosarcoma (RD) and human breast adenocarcinoma (MCF- 7) cells. This study focused on the death of cancer cells induced by LPG with minimum effects on healthy CC1 and to evaluate molecular mechanisms. The levels of GSH, NO, and caspase, DNA fragmentation and changes in morphology characteristic to apoptosis were investigated after treatment with LPG in RD and MCF-7 cancer cells. The results were compared with CC1 cells. A significant dose dependent decrease in protein synthesis and increase in NO levels were observed in both cancer cell types compared to CC1 cells. The reduction of GSH content and elevation of cell survival with exogenous GSH proved that the LPG caused cell death via induction of oxidative stress. Increase in caspase activity and DNA fragmentation were observed only in RD cells. The MCF-7 cells did not show any features of apoptosis. Thus, the present study provides evidence for that LPG stimulates oxidative stress by decreasing the levels of cellular total GSH levels and depletion of MMP in RD cells which in turn switching on the caspase cascade leads to apoptosis. Furthermore, the results reflect that MCF- 7 induces cell death in caspase independent pathway and less toxicity against CC1 cells by LPG.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Traditional Poly Herbal Drug Induced Apoptosis via Caspase 3 Mediated Pathway in RD Cells but Caspase 3 Independent Pathway in MCF-7 Cells","attachmentId":58053998,"attachmentType":"pdf","work_url":"https://www.academia.edu/38031688/A_Traditional_Poly_Herbal_Drug_Induced_Apoptosis_via_Caspase_3_Mediated_Pathway_in_RD_Cells_but_Caspase_3_Independent_Pathway_in_MCF_7_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/38031688/A_Traditional_Poly_Herbal_Drug_Induced_Apoptosis_via_Caspase_3_Mediated_Pathway_in_RD_Cells_but_Caspase_3_Independent_Pathway_in_MCF_7_Cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="92525085" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92525085/Characterization_of_dentatin_isolated_from_Clausena_excavate_and_its_potential_use_for_treatment_of_human_breast_and_prostate_cancers">Characterization of dentatin isolated from Clausena excavate and its potential use for treatment of human breast and prostate cancers</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2419442" href="https://independent.academia.edu/IsmaeelArbab">Ismail A D A M Arbab</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2012</p><p class="ds-related-work--abstract ds2-5-body-sm">To date, there has been no literature reported on the mechanism of dentatin and its effects on breast and prostate cancers. Hence, anti-cancer effect of dentatin was investigated towards breast (in vivo and in vitro) and prostate (in vitro) cancers. Ethnopharmacologically, Clausena excavata Burm. F., has been used as folk medicines in the eastern of Thailand for the treatment of cancer. Dentatin (DTN) was isolated from this plant via bio assay guided approach and its apoptosis mechanism was investigated. With respect to MCF-7 cells of breast, DTN induced cytotoxicity was observed using MTT assay. Acridine orange/Propidium iodide staining was used to detect the early apoptosis cells. High content screening (HCS) was used to observe the nuclear condensation,cell permeability, mitochondrial membrane potential (MMP) and cytochrome c release. Apoptosis was confirmed by using clonogenic assay, DNA laddering and caspase 3/7 and 9 assays. Reactive oxygen species formation, Bcl-2/Bax express...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Characterization of dentatin isolated from Clausena excavate and its potential use for treatment of human breast and prostate cancers","attachmentId":95511604,"attachmentType":"pdf","work_url":"https://www.academia.edu/92525085/Characterization_of_dentatin_isolated_from_Clausena_excavate_and_its_potential_use_for_treatment_of_human_breast_and_prostate_cancers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92525085/Characterization_of_dentatin_isolated_from_Clausena_excavate_and_its_potential_use_for_treatment_of_human_breast_and_prostate_cancers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="71561322" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/71561322/Ethyl_acetate_extract_of_Clausena_excavata_induces_growth_inhibition_of_non_small_lung_cancer_NCI_H460_cell_line_via_apoptosis">Ethyl acetate extract of Clausena excavata induces growth inhibition of non-small-lung cancer, NCI-H460, cell line via apoptosis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7460139" href="https://independent.academia.edu/RasedeeAbdullah">Rasedee Abdullah</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Applied Biomedicine</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Ethyl acetate extract of Clausena excavata induces growth inhibition of non-small-lung cancer, NCI-H460, cell line via apoptosis","attachmentId":80851997,"attachmentType":"pdf","work_url":"https://www.academia.edu/71561322/Ethyl_acetate_extract_of_Clausena_excavata_induces_growth_inhibition_of_non_small_lung_cancer_NCI_H460_cell_line_via_apoptosis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/71561322/Ethyl_acetate_extract_of_Clausena_excavata_induces_growth_inhibition_of_non_small_lung_cancer_NCI_H460_cell_line_via_apoptosis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="5366154" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5366154/Typhonium_flagelliforme_induces_apoptosis_in_CEMss_cells_via_activation_of_caspase_9_PARP_cleavage_and_cytochrome_c_release_Its_activation_coupled_with_G0_G1_phase_cell_cycle_arrest">Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: Its activation coupled with G0/G1 phase cell cycle arrest</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7460139" href="https://independent.academia.edu/RasedeeAbdullah">Rasedee Abdullah</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Ethnopharmacology, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: Its activation coupled with G0/G1 phase cell cycle arrest","attachmentId":49325131,"attachmentType":"pdf","work_url":"https://www.academia.edu/5366154/Typhonium_flagelliforme_induces_apoptosis_in_CEMss_cells_via_activation_of_caspase_9_PARP_cleavage_and_cytochrome_c_release_Its_activation_coupled_with_G0_G1_phase_cell_cycle_arrest","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5366154/Typhonium_flagelliforme_induces_apoptosis_in_CEMss_cells_via_activation_of_caspase_9_PARP_cleavage_and_cytochrome_c_release_Its_activation_coupled_with_G0_G1_phase_cell_cycle_arrest"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="15339879" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15339879/%CE%B1_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_%CE%BAB_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo">α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6545678" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34459209" href="https://independent.academia.edu/FirouzehDehghan">Firouzeh Dehghan</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="305137287" href="https://independent.academia.edu/NajihahHashim10">Najihah Hashim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Drug design, development and therapy, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">Cratoxylum arborescens is an equatorial plant belonging to the family Guttiferae. In the current study, α-Mangostin (AM) was isolated and its cell death mechanism was studied. HCS was undertaken to detect the nuclear condensation, mitochondrial membrane potential, cell permeability, and the release of cytochrome c. An investigation for reactive oxygen species formation was conducted using fluorescent analysis. To determine the mechanism of cell death, human apoptosis proteome profiler assay was conducted. In addition, using immunofluorescence and immunoblotting, the levels of Bcl-2-associated X protein (Bax) and B-cell lymphoma (Bcl)-2 proteins were also tested. Caspaces such as 3/7, 8, and 9 were assessed during treatment. Using HCS and Western blot, the contribution of nuclear factor kappa-B (NF-κB) was investigated. AM had showed a selective cytotoxicity toward the cancer cells with no toxicity toward the normal cells even at 30 μg/mL, thereby indicating that AM has the attribute...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo","attachmentId":43319190,"attachmentType":"pdf","work_url":"https://www.academia.edu/15339879/%CE%B1_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_%CE%BAB_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15339879/%CE%B1_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_%CE%BAB_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="792120" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/792120/Typhonium_flagelliforme_induces_apoptosis_in_CEMss_cells_via_activation_of_caspase_9_PARP_cleavage_and_cytochrome_c_release_Its_activation_coupled_with_G0_G1_">Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: Its activation coupled with G0/G1 …</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="198729" href="https://malaya.academia.edu/SiddigIbrahim">Siddig Abdelwahab</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of …, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: Its activation coupled with G0/G1 …","attachmentId":51237646,"attachmentType":"pdf","work_url":"https://www.academia.edu/792120/Typhonium_flagelliforme_induces_apoptosis_in_CEMss_cells_via_activation_of_caspase_9_PARP_cleavage_and_cytochrome_c_release_Its_activation_coupled_with_G0_G1_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/792120/Typhonium_flagelliforme_induces_apoptosis_in_CEMss_cells_via_activation_of_caspase_9_PARP_cleavage_and_cytochrome_c_release_Its_activation_coupled_with_G0_G1_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":51085018,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":51085018,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_51085018" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="50496722" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/50496722/Mohd_Zabidi_Majid_Zuraiza_Mohamad_Zaini_and_Fathilah_Abdul_Razak_2014_Apoptosis_Inducing_Effect_of_Three_Medicinal_Plants_on_Oral_Cancer_Cells_KB_and_ORL_48_The_Scientific_World_Journal_vol_2014_Article_ID_125353_8_pages_doi_10_1155_2014_125353">Mohd Zabidi Majid, Zuraiza Mohamad Zaini & Fathilah Abdul Razak. 2014. Apoptosis-Inducing Effect of Three Medicinal Plants on Oral Cancer Cells KB and ORL-48. The Scientific World Journal. vol 2014. Article ID 125353, 8 pages. doi:10.1155/2014/125353</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38541561" href="https://malaya.academia.edu/FathilahRazak">Fathilah Razak</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Scientific World Journal</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mohd Zabidi Majid, Zuraiza Mohamad Zaini \u0026 Fathilah Abdul Razak. 2014. Apoptosis-Inducing Effect of Three Medicinal Plants on Oral Cancer Cells KB and ORL-48. The Scientific World Journal. vol 2014. Article ID 125353, 8 pages. doi:10.1155/2014/125353","attachmentId":68460100,"attachmentType":"pdf","work_url":"https://www.academia.edu/50496722/Mohd_Zabidi_Majid_Zuraiza_Mohamad_Zaini_and_Fathilah_Abdul_Razak_2014_Apoptosis_Inducing_Effect_of_Three_Medicinal_Plants_on_Oral_Cancer_Cells_KB_and_ORL_48_The_Scientific_World_Journal_vol_2014_Article_ID_125353_8_pages_doi_10_1155_2014_125353","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/50496722/Mohd_Zabidi_Majid_Zuraiza_Mohamad_Zaini_and_Fathilah_Abdul_Razak_2014_Apoptosis_Inducing_Effect_of_Three_Medicinal_Plants_on_Oral_Cancer_Cells_KB_and_ORL_48_The_Scientific_World_Journal_vol_2014_Article_ID_125353_8_pages_doi_10_1155_2014_125353"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="15339878" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15339878/Involvement_of_NF_%CE%BAB_and_HSP70_signaling_pathways_in_the_apoptosis_of_MDA_MB_231_cells_induced_by_a_prenylated_xanthone_compound_%CE%B1_mangostin_from_Cratoxylum_arborescens">Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6545678" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34459209" href="https://independent.academia.edu/FirouzehDehghan">Firouzeh Dehghan</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="305137287" href="https://independent.academia.edu/NajihahHashim10">Najihah Hashim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Drug design, development and therapy, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens","attachmentId":43319181,"attachmentType":"pdf","work_url":"https://www.academia.edu/15339878/Involvement_of_NF_%CE%BAB_and_HSP70_signaling_pathways_in_the_apoptosis_of_MDA_MB_231_cells_induced_by_a_prenylated_xanthone_compound_%CE%B1_mangostin_from_Cratoxylum_arborescens","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15339878/Involvement_of_NF_%CE%BAB_and_HSP70_signaling_pathways_in_the_apoptosis_of_MDA_MB_231_cells_induced_by_a_prenylated_xanthone_compound_%CE%B1_mangostin_from_Cratoxylum_arborescens"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="112113604" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/112113604/Activation_of_Apoptosis_by_1_Hydroxy_5_7_Dimethoxy_2_Naphthalene_Carboxaldehyde_a_Novel_Compound_from_i_Aegle_marmelos_i_">Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene-Carboxaldehyde, a Novel Compound from <i>Aegle marmelos</i></a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="30761569" href="https://independent.academia.edu/NMurmu">Nabendu Murmu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer Research, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene-Carboxaldehyde, a Novel Compound from \u003ci\u003eAegle marmelos\u003c/i\u003e","attachmentId":109444293,"attachmentType":"pdf","work_url":"https://www.academia.edu/112113604/Activation_of_Apoptosis_by_1_Hydroxy_5_7_Dimethoxy_2_Naphthalene_Carboxaldehyde_a_Novel_Compound_from_i_Aegle_marmelos_i_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/112113604/Activation_of_Apoptosis_by_1_Hydroxy_5_7_Dimethoxy_2_Naphthalene_Carboxaldehyde_a_Novel_Compound_from_i_Aegle_marmelos_i_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div 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