Natural Product Reports journal

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data-img-src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/00-journal-pages-heros/Natural-Product-Reports-HERO.jpg?version=9d204890&width=800&format=jpg&quality=80" data-img-alt="Top Image"><img class="slimmage" src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/00-journal-pages-heros/Natural-Product-Reports-HERO.jpg?version=9d204890&width=800&format=jpg&quality=80" alt="Top Image"></noscript> </div> <div class="top-image-area__overlay"></div> <div class="top-image-area__gradient"></div> <div class="grid-container"> <div class="top-image-area__header"> <div class="header_inner_content"> <h1 class="home-header-with-drop">Natural Product Reports</h1> <p class="home-header-with-drop"> The journal for high impact, critical reviews in natural products research and related areas </p> </div> <div class="top-image-area__cta"> <a class="cta__link cta--yellow click-ripple" href="https://pubs.rsc.org/en/journals/journalissues/np#!recentarticles&adv"> <img class="click-ripple" src="https://epi-rsc.rsc-cdn.org/public/img/local/ripple-bg.png?version=20240326094334" width="300" height="300" alt="" style="display: block; opacity: 0; width: 0px; height: 0px; margin: 0px;"> <div class="cta__block"> <span class="cta__copy">Read this journal</span> <b class="cta__block__icon add-icon-after-go-arrow-right"></b> </div> </a> <a class="cta__link cta--blue click-ripple" href="/globalassets/05-journals-books-databases/our-journals/natural-product-reports/npr-synopsis-guidelines.pdf"> <img class="click-ripple" src="https://epi-rsc.rsc-cdn.org/public/img/local/ripple-bg.png?version=20240326094334" width="300" height="300" alt="" style="display: block; opacity: 0; width: 0px; height: 0px; margin: 0px;"> <div class="cta__block"> <span class="cta__copy">How to submit a Synopsis</span> <b class="cta__block__icon add-icon-after-go-arrow-right"></b> </div> </a> </div> </div> </div> </div> <main class="main layout-a2" role="main" id="maincontent"> <div class="grid-container"> <div class="layout-a2__col-a ac-outer-container"> <div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <div class="rsc-ui"> <div class="row"> <div class="column"> <div class="bg-warning pad-sm"><strong>Setting up remote access to RSC content</strong> <p>You can find details about how to access information remotely in this <a href="/about-us/corporate-information/covid-19-response/publishing-remote-access/" target="_blank" rel="noopener">step-by-step guide</a>. The guide will also help if for any reason you have difficulty accessing the content you want.</p> </div> </div> </div> </div> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <h2>What would you like to know about this journal?</h2> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <p style="font-size: 20px; border-left-style: solid; border-color: #004976; border-left-width: 8px; padding: 10px;"><strong><em>Natural Product Reports</em> is a Transformative Journal and Plan S compliant</strong></p> <div class="rsc-ui"> <div class="row edge2edge-lg"> <div class="column two padh-sm"> <div class="pad-sm"> <p style="font-size: 20px; border-left-style: solid; border-color: #D3D3D3; border-left-width: 8px; padding: 10px;">Impact factor: 10.2*</p> <p style="font-size: 20px; border-left-style: solid; border-color: #D3D3D3; border-left-width: 8px; padding: 10px;">Time to first decision (all decisions): 42.0 days**</p> <p style="font-size: 20px; border-left-style: solid; border-color: #D3D3D3; border-left-width: 8px; padding: 10px;">Time to first decision (peer reviewed only): 42.5 days***</p> </div> </div> <div class="column two padh-sm"> <div class="pad-sm"> <p style="font-size: 20px; border-left-style: solid; border-color: #D3D3D3; border-left-width: 8px; padding: 10px;">Chair: Tobias Gulder</p> <p style="font-size: 20px; border-left-style: solid; border-color: #D3D3D3; border-left-width: 8px; padding: 10px;">Indexed in MEDLINE</p> <p style="font-size: 20px; border-left-style: solid; border-color: #D3D3D3; border-left-width: 8px; padding: 10px;">CiteScore: 21.2****</p> <p style="font-size: 20px; border-left-style: solid; border-color: #D3D3D3; border-left-width: 8px; padding: 10px;">Open access publishing options available</p> </div> </div> </div> <div class="row edge2edge-lg"> <div class="column two padh-sm"> <div class="pad-sm"> <p><a class="bg-dk-blue pad-xsm block" href="https://pubs.rsc.org/en/journals/journalissues/np#!recentarticles&adv">Read this journal</a></p> <p><a class="bg-dk-blue pad-xsm block" href="/globalassets/05-journals-books-databases/our-journals/natural-product-reports/npr-synopsis-guidelines.pdf">How to submit a synopsis</a></p> <p><a class="bg-dk-blue pad-xsm block" href="https://www.rsc.org/Publishing/Journals/forms/V5profile.asp" target="_blank" rel="noopener">Sign up for regular email alerts</a></p> </div> </div> <div class="column two padh-sm"> <div class="pad-sm"> <p><a class="bg-dk-blue pad-xsm block" href="/journals-books-databases/about-journals/metrics/">View all journal metrics</a></p> <p><a class="bg-dk-blue pad-xsm block" href="/journals-books-databases/about-journals/npr/#open-access">Publish open access</a></p> <p><a class="bg-dk-blue pad-xsm block" href="/journals-books-databases/about-journals/npr/#team">Meet the team</a></p> </div> </div> </div> </div> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <hr> </div> </div><div class="block a2maintextblock "> <div class="text-image-block hashtaglink" id="scope"> <div class="text-image-block__bd"> <h2>Journal scope</h2> <p><em><em>Natural Product Reports (</em>NPR) </em>is a critical review journal that stimulates progress in all areas of natural products research, including isolation, structural and stereochemical determination, biosynthesis, biological activity and synthesis.</p> <p>The scope of the journal is very broad, and many reviews discuss the role of natural products in the wider bioinorganic, bioorganic and chemical biology communities. Areas covered include the following:</p> <ul> <li>Enzymology</li> <li>Nucleic acids</li> <li>Genetics</li> <li>Chemical ecology</li> <li>Carbohydrates</li> <li>Primary and secondary metabolism</li> <li>Analytical techniques</li> </ul> </div> <div class="text-image-block__img"> <noscript data-slimmage="true" data-img-class="slimmage hashtaglink" data-img-src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/00-cover-images/natural-product-reports-journal-cover.jpg?version=9e7286f3&width=800&format=jpg&quality=80" data-img-alt="image block"><img class="slimmage hashtaglink" src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/00-cover-images/natural-product-reports-journal-cover.jpg?version=9e7286f3&width=800&format=jpg&quality=80" alt="image block"></noscript> </div> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink" id="scope2"> <p><em>NPR</em> articles are designed to give an interesting insight into the topic, focusing on the key developments that have shaped a field. Authors are encouraged to include their own perspective on developments, trends and future directions. Articles providing a very comprehensive overview or exhaustive list of previous literature and lacking critical insight are generally not suitable for publication in <em>NPR</em>.</p> <p>Meta-analyses of previously published data using existing tools can be included, however <em>NPR</em> articles should not include any new methods or data.</p> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <hr> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink" id="Lectureship_Info_NPR"> <h2>Natural Product Reports Lectureship </h2> <p>This Lectureship recognises an outstanding emerging investigator who has made a significant contribution to a natural products-related area of the chemical sciences, providing a platform to showcase their research to the wider scientific community. The <em>NPR</em> Lectureship is awarded annually through a process whereby nominations of candidates are invited from our community.</p> <p>You can read about eligibility, how to nominate, see deadlines and all of the winners.</p> <p> </p> <a href="/journals-books-databases/about-journals/npr/natural-product-reports-emerging-investigator-lectureship-award/" class="btn">Find out more</a> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <hr> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink" id="team"> <h2>Meet the team</h2> <p>Find out who is on the editorial and advisory boards for the <em>Natural Product Reports</em> journal.</p> </div> </div><div class="block tabsblock "><div class="tabs hashtaglink" id="boards-staff"> <div><div class="block tabsinnerblock "><div class="tabs__content hashtaglink"> <span class="tab__heading" style="display: none;">Editorial board</span> <div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <h4>Chair</h4> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np_gulder"><strong>Tobias Gulder</strong></a>, Technical University of Dresden and Helmholtz Institute for Pharmaceutical Research Saarland, Germany</p> <h4>Editorial board members</h4> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np_brotz_oesterhelt"><strong>Heike Brötz-Oesterhelt</strong></a>, University of Tübingen, Germany</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np_cech"><strong>Nadja Cech</strong></a>, University of North Carolina, Greensboro, USA</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#NP_Eustaquio"><strong>Alessandra Eustaquio</strong></a>, University of Illinois at Chicago, USA</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np_Linington"><strong>Roger Linington</strong></a>, Simon Fraser University, Canada</p> <p><strong><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np_Oh">Dong-Chan Oh</a></strong>, Seoul National University, South Korea</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#cassandra-quave"><strong>Cassandra Quave</strong></a>, Emory University, USA</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np-sosio"><strong>Margherita Sosio</strong></a>, Naicons Srl, Milan, Italy</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np_Takano"><strong>Eriko Takano</strong></a>, University of Manchester, UK</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#NP_Tokuyama"><strong>Hidetoshi Tokuyama</strong></a>, Tohoku University, Japan</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np_Vanderwal"><strong>Christopher Vanderwal</strong></a>, University of California, Irvine, USA</p> <p><a href="/journals-books-databases/about-journals/npr/editorial-board-members/#np_Zhang"><strong>Changsheng Zhang</strong></a>, South China Sea Institute of Oceanology, China Academy of Sciences, China</p> </div> </div></div> </div> </div><div class="block tabsinnerblock "><div class="tabs__content hashtaglink" id="AB"> <span class="tab__heading" style="display: none;">Advisory board</span> <div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <p><strong>Giovanni Appendino</strong>, Universita del Piemonte Orientale, Italy</p> <p><strong>Roberto Berlinck</strong>, University of Sao Paulo, Brazil</p> <p><strong>Carole Bewley</strong>, National Institutes of Health, USA</p> <p><strong>Christopher Boddy</strong>, University of Ottawa, Canada</p> <p><strong>Robert Britton</strong>, Simon Fraser University, Canada</p> <p><strong>Margaret A Brimble</strong>, University of Auckland, New Zealand</p> <p><strong>Mark Brönstrup</strong>, Helmholtz Centre for Infection Research, Germany</p> <p><strong>Guy Carter</strong>, Carter-Bernan Consulting, USA</p> <p><strong>Russell Cox</strong>, Leibniz Universität Hannover, Germany</p> <p><strong>Pieter Dorrestein</strong>, University of California, San Diego, USA</p> <p><strong>Katherine Duncan</strong>, Newcastle University, UK</p> <p><strong>Neha Garg</strong>, Georgia Institute of Technology, USA</p> <p><strong>Susana P. Gaudêncio</strong>, Nova University Lisbon, Portugal</p> <p><strong>Olga Genilloud</strong>, Fundación MEDINA, Spain</p> <p><strong>Rebecca Goss</strong>, St. Andrews University, UK</p> <p><strong>Seth Herzon</strong>, Yale University, USA</p> <p><strong>Chambers Hughes</strong>, University of Tübingen, Germany</p> <p><strong>Marcel Jaspars</strong>, University of Aberdeen, UK</p> <p><strong>Martin Kaltenpoth</strong>, Max Planck Institute for Chemical Ecology, Germany</p> <p><strong>Andreas Kirschning</strong>, University of Hannover, Germany</p> <p><strong>Julia Kubanek</strong>, Georgia Institute of Technology, USA</p> <p><strong>Wen Liu</strong>, Shanghai Institute of Organic Chemistry, China</p> <p><strong>Sandra Loesgen</strong>, University of Florida, USA</p> <p><strong>Hendrik Luesch</strong>, University of Florida, USA</p> <p><strong>Dawei Ma</strong>, Shanghai Institute of Organic Chemistry, China</p> <p><strong>Marnix Medema</strong>, Wageningen University, Netherlands</p> <p><strong>Fidele Ntie-Kang</strong>, University of Buea, Cameroon</p> <p><strong>Sarah O'Connor</strong>, Max Planck Institute for Chemical Ecology, Jena, Germany</p> <p><strong>Jörn Piel</strong>, ETH Zurich, Switzerland</p> <p><strong>Jürgen Rohr</strong>, University of Kentucky, USA</p> <p><strong>Martin Schmeing</strong>, McGill University, Canada</p> <p><strong>Stefan Schulz</strong>, TU Braunschweig, Germany</p> <p><strong>Michael Sherburn</strong>, Australia National University, Australia</p> <p><strong>Thomas J Simpson</strong>, University of Bristol, UK</p> <p><strong>Janet Smith</strong>, University of Michigan, USA</p> <p><strong>Renxiang Tan</strong>, Nanjing University, China</p> <p><strong>Dirk</strong> <strong>Trauner</strong>, University of Pennsylvania, USA</p> <p><strong>Reiko Ueoka</strong>, Kitasato Universit, Japan</p> <p><strong>Justin Van der Hooft</strong>, Wageningen University, Netherlands</p> <p><strong>Kira Weissman</strong>, Lorraine University, France</p> <p><strong>Craig Williams</strong>, The University of Queensland, Australia</p> <p><strong>Zhen Yang</strong>, Peking University, China</p> <p><strong>Yeo Joon Yoon</strong>, Seoul National University, Korea</p> <p><strong>Weidong Zhang</strong>, Second Military Medical University, Shanghai, China</p> </div> </div></div> </div> </div><div class="block tabsinnerblock "><div class="tabs__content hashtaglink" id="EO"> <span class="tab__heading" style="display: none;">Editorial office</span> <div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <p><strong>Katie Lim</strong>, Executive Editor</p> <p><strong>Grace Thoburn</strong>, Deputy Editor</p> <p><strong>Daniel Robertshaw</strong>, Development Editor</p> <p><strong>Sarah Anthony</strong>, Editorial Production Manager</p> <p><strong>Nicola Burton</strong>, Publishing Editor</p> <p><strong>Tom Cozens</strong>, Publishing Editor</p> <p><strong>Ryan Kean</strong>, Publishing Editor</p> <p><strong>Roxane Owen</strong>, Publishing Editor, ORCID <a href="http://orcid.org/0000-0002-4553-233X">0000-0002-4553-233X</a> </p> <p><strong>Andrea Whiteside</strong>, Publishing Assistant</p> <p><strong>Sam Keltie</strong>, Publisher, Journals, ORCID <a href="http://orcid.org/0000-0002-9369-8414">0000-0002-9369-8414</a></p> </div> </div></div> </div> </div></div> </div> </div><div class="block expandablecontentblock "> <div class="content-block hashtaglink"> <h2>Article types</h2> <p><p><em>Natural Product Reports </em>publishes:</p> <ul> <li>Reviews</li> <li>Highlights</li> <li>Viewpoints</li> <li>Hot off the press articles</li> </ul> <p><em>NPR</em> articles are generally solicited by members of the Editorial Board, however we welcome proposals from the research community. If you are interested in writing an article for <em>NPR</em>, please contact the Editorial Office with a brief synopsis.</p> <p>Synopses for all proposed articles are considered by the board before a decision on the commissioning of the full article is taken.</p> <p><strong><a href="/globalassets/05-journals-books-databases/our-journals/natural-product-reports/npr-synopsis-guidelines.pdf">How to submit a synopsis to NPR</a></strong></p> <a class="btn--expandable" data-expandable="" aria-controls="3228ef83-1cff-4e13-81eb-f4815538be7a" href="javascript:;">See more information about these article types<b class="add-icon-after-plus"></b></a> <div class="content-block__expandable inactive" id="3228ef83-1cff-4e13-81eb-f4815538be7a" data-status="is-expanded" aria-expanded="true"> <div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <h3>Review articles</h3> <p>Critical reviews of key areas of research, focusing on key developments rather than comprehensive accounts of everything that has occurred in the field; generally 10–25 pages in length.</p> <h3>Highlight articles</h3> <p>Concise, non-comprehensive reviews which give a 'snapshot' of a hot or specialist research area; 4–8 pages in length, generally with up to 8 display items and 50 references.</p> <h3>Viewpoint articles</h3> <p>Short articles that focus on some of the key challenges, issues or developments in natural products research. They can be "opinion" style articles, which give the author's perspective on a particular issue, backed up by the literature. Up to 4 pages in length, generally with up to 3 display items and 20 references.</p> <h3>Hot off the press articles</h3> <p>Bi-monthly digests of the latest natural products research, written by Bob Hill and Andrew Sutherland at the University of Glasgow, UK.</p> <p> </p> </div> </div></div> </div> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <hr> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink" id="TPR_np"> <h2>Transparent peer review</h2> <p>As part of our commitment to transparency and open science, <em>Natural Product Reports</em> is now offering authors the option of transparent peer review, where the editor’s decision letter, reviewers’ comments and authors’ response for all versions of the manuscript will be published alongside the article under an <a href="https://creativecommons.org/licenses/by/4.0/">Open Access Creative Commons licence (CC-BY)</a>. Please note comments and decisions on synopses will not be published.</p> <p>Reviewers will remain anonymous unless they choose to sign their report.</p> <p><a class="btn bg-dk-blue" href="/journals-books-databases/author-and-reviewer-hub/process-and-policies/#peerreview">Find out more about our transparent peer review policy</a></p> </div> </div><div class="block expandablecontentblock "> <div class="content-block hashtaglink"> <p><hr> <h2>Journal specific guidelines</h2> <div class="content-block hashtaglink"> <div style="color: #2c4d67; background-color: #f9f8f8; width: 100%; border-style: solid; border-color: #2c4d67; padding: 10px; border-width: 2px 2px 2px 8px;">The following guidelines are journal specific. For general guidance on preparing an article please visit our <a href="/journals-books-databases/author-and-reviewer-hub/authors-information/prepare-and-format/">Prepare your article</a> and <a href="/journals-books-databases/author-and-reviewer-hub/authors-information/">Resources for authors</a> pages, the content of which is relevant to all of our journals.</div> </div> <a class="btn--expandable" data-expandable="" aria-controls="c6614e41-9859-4829-9afe-89db81fca857" href="javascript:;">See more Journal specific guidelines<b class="add-icon-after-plus"></b></a> <div class="content-block__expandable inactive" id="c6614e41-9859-4829-9afe-89db81fca857" data-status="is-expanded" aria-expanded="true"> <div><div class="block expandablecontentblock "> <div class="content-block hashtaglink"> <p><h3>Guidelines on writing titles, abstracts & table of contents entry</h3> <p>The title, abstract and table of contents entry (graphical abstract) are the first parts of your manuscript that editors, referees and potential readers will see, and once published they play a major part in a researcher’s decision to read your article. Therefore it’s important that these clearly and concisely summarise the topic of your review and its significance.</p> <h4>Title</h4> <p>The title should be short and straightforward to appeal to a general reader, but detailed enough to properly reflect the contents of your review article.</p> <ul> <li>Keep it relatively short – between 8 and 15 words is ideal.</li> <li>Use easily recognisable words and phrases that can be read quickly.</li> <li>Use general or well-known terms for compounds and procedures rather than very specialised terms or nomenclature.</li> <li>Avoid using non-standard abbreviations and symbols.</li> <li>Use keywords and familiar, searchable terms – these can increase the chances of your article appearing in search results. Around 70% of our readers come directly <em>via</em> search engines.</li> </ul> <h4>Abstract</h4> <p>The abstract is a single paragraph which summarises the contents of your article. It will help readers to decide whether your article is of interest to them.</p> <ul> <li>The length can vary from 50 to 250 words (or up to 100 words for Highlight articles), but it should always be concise and easy to read with recognisable words and phrases.</li> <li>It should summarise the research area that your review covers, including why it is important.</li> <li>Like your title, make sure you use familiar, searchable terms and keywords.</li> </ul> <h4>Table of contents entry</h4> <p>A table of contents entry (graphical abstract) is required, which should be submitted at the revision stage. This should include an eye-catching graphic and 1-2 sentence(s) of text to summarise the key findings of the article to the reader. It will appear in the table of contents and feeds – for example, RSS feeds.</p> <p><strong>The graphic should:</strong></p> <ul> <li>Be simple, but informative.</li> <li>Capture the reader’s attention (the use of colour is encouraged).</li> <li>Include a structure, scheme, graph, drawing, photograph or combination that conveys the message of the article. Please note, complex schematics or spectra should be avoided.</li> <li>Be original, unpublished artwork created by one of the co-authors. Preferably, the graphic should not be reused and appear again within the article.</li> <li>Be suitable for, and uphold the standards of, a scholarly publication that has a global reach.</li> <li>Not contain any elements that are offensive or inappropriate, in particular words or images that are discriminatory.</li> <li>Not contain large amounts of text. Text should be limited to the labelling of compounds, reaction arrows and diagrams, with long phrases or sentences being avoided. Any text should be clearly legible to a reader.</li> <li>Not contain logos, trademarks or brands names.</li> </ul> <p><strong>The text should:</strong></p> <ul> <li>Be concise and focus only on the key findings of the manuscript and their importance, not the processes used; think about what would grab the attention of the potential reader and would encourage them to read the full article.</li> <li>Avoid repeating or paraphrasing the title or abstract.</li> <li>Use easily recognisable words and phrases that can be read quickly.</li> </ul> <p><strong>Table of contents specifications:</strong></p> <ul> <li>The figure should be a maximum size of 8 cm wide x 4 cm high.</li> <li>Figures should be supplied as TIFF files, with a resolution of 600 dpi or greater.</li> <li>The text supplied should be 1-2 sentences long, using a maximum of 250 characters.</li> </ul> <a class="btn--expandable" data-expandable="" aria-controls="381546ea-bbca-4197-ada4-5c5766579d91" href="javascript:;">Examples of suitable titles, abstracts and table of contents information<b class="add-icon-after-plus"></b></a> <div class="content-block__expandable inactive" id="381546ea-bbca-4197-ada4-5c5766579d91" data-status="is-expanded" aria-expanded="true"> <div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <h4>Titles</h4> <p><strong>Chemical proteomics approaches for identifying the cellular targets of natural products</strong><br>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2016/np/c6np00001k">10.1039/C6NP00001K</a></p> <p><strong>Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks</strong><br>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2016/np/c5np00050e">10.1039/C5NP00050E</a></p> <p><strong>A twist of nature – the significance of atropisomers in biological systems</strong><br>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2015/np/c4np00121d">10.1039/C4NP00121D</a></p> <h4>Abstracts</h4> <p>This highlight provides an overview of recent progress towards elucidating the structure, biosynthesis, and mode of action of colibactin, a genotoxic secondary metabolite synthesized by human gut bacteria. While isolating colibactin has been problematic, efforts to characterize its biosynthesis have provided critical information that has led to a rapid increase in our knowledge of this metabolite's structure and function. Major questions and gaps remain however, and the broader lessons learned from studying colibactin underscore central challenges to be faced in the genomics era of natural product research and in efforts to understand the human microbiome.<br>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2015/np/c5np00091b">10.1039/C5NP00091B<br><br></a>Deconvoluting the mode of action of natural products and drugs remains one of the biggest challenges in chemistry and biology today. Chemical proteomics is a growing area of chemical biology that seeks to design small molecule probes to understand protein function. In the context of natural products, chemical proteomics can be used to identify the protein binding partners or targets of small molecules in live cells. Here, we highlight recent examples of chemical probes based on natural products and their application for target identification. The review focuses on probes that can be covalently linked to their target proteins (either via intrinsic chemical reactivity or via the introduction of photocrosslinkers), and can be applied “in situ” – in living systems rather than cell lysates. We also focus here on strategies that employ a click reaction, the copper-catalysed azide–alkyne cycloaddition reaction (CuAAC), to allow minimal functionalisation of natural product scaffolds with an alkyne or azide tag. We also discuss ‘competitive mode’ approaches that screen for natural products that compete with a well-characterised chemical probe for binding to a particular set of protein targets. Fuelled by advances in mass spectrometry instrumentation and bioinformatics, many modern strategies are now embracing quantitative proteomics to help define the true interacting partners of probes, and we highlight the opportunities this rapidly evolving technology provides in chemical proteomics. Finally, some of the limitations and hallenges of chemical proteomics approaches are discussed.<br>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2016/np/c6np00001k">10.1039/C6NP00001K</a></p> <p>While recent breakthroughs in the discovery of peptide antibiotics and other Peptidic Natural Products (PNPs) raise a challenge for developing new algorithms for their analyses, the computational technologies for high-throughput PNP discovery are still lacking. We discuss the computational bottlenecks in analyzing PNPs and review recent advances in genome mining, peptidogenomics, and spectral networks that are now enabling the discovery of new PNPs via mass spectrometry. We further describe the connections between these advances and the new generation of software tools for PNP dereplication, de novo sequencing, and identification.<br>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2016/np/c5np00050e">10.1039/C5NP00050E</a></p> </div> </div><div class="block a2maintextblock "> <div class="text-image-block hashtaglink"> <div class="text-image-block__bd"> <h4>Table of contents</h4> <p>In this Viewpoint article we examine the roles of bacterially produced small molecules in animal defense, development and evolution.<br>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2015/np/c4np00141a">10.1039/C4NP00141A</a></p> </div> <div class="text-image-block__img"> <noscript data-slimmage="true" data-img-class="slimmage hashtaglink" data-img-src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/natural-product-reports/1912-natural-product-reports_f2a-1200.jpg?version=3f1b9418&width=800&format=jpg&quality=80" data-img-alt="image block"><img class="slimmage hashtaglink" src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/natural-product-reports/1912-natural-product-reports_f2a-1200.jpg?version=3f1b9418&width=800&format=jpg&quality=80" alt="image block"></noscript> </div> </div> </div><div class="block a2maintextblock "> <div class="text-image-block hashtaglink"> <div class="text-image-block__bd"> <p><span style="font-family: Arial, sans-serif;">This highlight reviews recent studies of colibactin, a structurally uncharacterized genotoxin synthesised by members of the human gut microbiota.<br></span>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2015/np/c5np00091b">10.1039/C5NP00091B</a></p> </div> <div class="text-image-block__img"> <noscript data-slimmage="true" data-img-class="slimmage hashtaglink" data-img-src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/natural-product-reports/1913-natural-product-reports_f2a-1200.jpg?version=3f1b9418&width=800&format=jpg&quality=80" data-img-alt="image block"><img class="slimmage hashtaglink" src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/natural-product-reports/1913-natural-product-reports_f2a-1200.jpg?version=3f1b9418&width=800&format=jpg&quality=80" alt="image block"></noscript> </div> </div> </div><div class="block a2maintextblock "> <div class="text-image-block hashtaglink"> <div class="text-image-block__bd"> <p>This highlight focuses on one of Nature's key strategies to doubly modify an amino acid during nonribosomal peptide biosynthesis by using a single enzyme, an interrupted adenylation domain.<br>From DOI: <a href="https://pubs.rsc.org/en/content/articlelanding/2015/np/c4np00120f">10.1039/C4NP00120F</a></p> </div> <div class="text-image-block__img"> <noscript data-slimmage="true" data-img-class="slimmage hashtaglink" data-img-src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/natural-product-reports/1911-natural-product-reports_f2a-1200.jpg?version=3f1b9417&width=800&format=jpg&quality=80" data-img-alt="image block"><img class="slimmage hashtaglink" src="https://epi-rsc.rsc-cdn.org/globalassets/05-journals-books-databases/our-journals/natural-product-reports/1911-natural-product-reports_f2a-1200.jpg?version=3f1b9417&width=800&format=jpg&quality=80" alt="image block"></noscript> </div> </div> </div></div> </div> </div> </div></div> </div> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink"> <hr> </div> </div><div class="block a2maintextblock "> <div class="content-block hashtaglink" id="open-access"> <h2>Open access publishing options</h2> <p><em>Natural Product Reports</em> is a hybrid (transformative) journal and gives authors the choice of publishing their research either via the traditional subscription-based model or instead by choosing our gold open access option. <a href="/journals-books-databases/open-access-publishing/how-to-publish-open-access/#more-options">Find out more about our Transformative Journals.</a> which are <a href="/policy-evidence-campaigns/open-access-and-plan-s/">Plan S compliant</a>.</p> <h3>Gold open access</h3> <p>For authors who want to publish their article <a href="/journals-books-databases/open-access-publishing/how-to-publish-open-access/#gold-oa">gold open access</a>, <em>Natural Product Reports</em> charges an article processing charge (APC) of £2,500 (+ any applicable tax). Our APC is all-inclusive and makes your article freely available online immediately, permanently, and includes your choice of <a href="/journals-books-databases/open-access-publishing/how-to-publish-open-access/#licences">Creative Commons licence</a> (CC BY or CC BY-NC) at no extra cost. It is not a submission charge, so you only pay if your article is accepted for publication.</p> <p><a href="/journals-books-databases/open-access-publishing/">Learn more about publishing open access</a>.</p> <h3>Read & Publish</h3> <p>If your institution has a Read & Publish agreement in place with the Royal Society of Chemistry, APCs for gold open access publishing in <em>Natural Product Reports</em> may already be covered.</p> <p> </p> <div class="content-block hashtaglink"> <div class="rsc-ui"> <div> <blockquote> <p>Use our <a href="https://rsc.chronoshub.io/?fq=">journal finder</a> to check if your institution has an open access agreement with us.</p> </blockquote> </div> </div> </div> <p>Please use your official institutional email address to submit your manuscript and check you are assigned as the corresponding author; this helps us to identify if you are eligible for Read & Publish or other APC discounts.</p> <h3>Traditional subscription model</h3> <p>Authors can also publish in <em>Natural Product Reports </em>via the traditional subscription model without needing to pay an APC. Articles published via this route are available to institutions and individuals who subscribe to the journal. Our standard licence allows you to make the accepted manuscript of your article freely available after a 12-month embargo period. 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