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class="data">9</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="3893510" href="https://www.academia.edu/Documents/in/New_Spain"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/Jos%C3%A9MtzMtz","location":"/Jos%C3%A9MtzMtz","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/Jos%C3%A9MtzMtz","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" 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Conway"]}" data-trace="false" data-dom-id="Pill-react-component-ae6854e6-7ec7-4263-a557-2be6bc88b824"></div> <div id="Pill-react-component-ae6854e6-7ec7-4263-a557-2be6bc88b824"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by José Mtz Mtz</h3></div><div class="js-work-strip profile--work_container" data-work-id="3356172"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356172/S_Adenosylmethionine_in_cell_growth_apoptosis_and_liver_cancer"><img alt="Research paper thumbnail of S‐Adenosylmethionine in cell growth, apoptosis and liver cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/50317929/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356172/S_Adenosylmethionine_in_cell_growth_apoptosis_and_liver_cancer">S‐Adenosylmethionine in cell growth, apoptosis and liver cancer</a></div><div class="wp-workCard_item"><span>Journal of gastroenterology and hepatology</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="340cfbb876c1f9efb97044a33388fae3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317929,"asset_id":3356172,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317929/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356172"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356172"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356172; 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In mammals, two genes (MAT1A and MAT2A), encode for two homologous MAT catalytic subunits, while a third gene MAT2β, encodes for the β-subunit that regulates MAT2A-encoded isoenzyme. Normal liver expresses MAT1A, whereas extrahepatic tissues express MAT2A. MAT2A and MAT2β are induced in human hepatocellular carcinoma (HCC), which facilitate cancer cell growth. Patients with cirrhosis of various etiologies, including alcohol, have decreased hepatic MAT activity and SAMe biosynthesis. Consequences of hepatic SAMe deficiency as illustrated by the Mat1a knock-out mouse model include increased susceptibility to steatosis and oxidative liver injury, spontaneous development of steatohepatitis and HCC. Predisposition to HCC can be partly explained by the effect of SAMe on growth. Thus, SAMe inhibits the mitogenic effect of growth factors such as hepatocyte growth factor and, following partial hepatectomy, a fall in SAMe level is required for the liver to regenerate. During liver regeneration, the fall in hepatic SAMe is transient. If the fall were to persist, it would favor a proliferative phenotype and, ultimately, development of HCC. Not only does SAMe control liver growth, it also regulates apoptosis. Interestingly, SAMe is anti-apoptotic in normal hepatocytes but pro-apoptotic in liver cancer cells. In liver cancer cells but not in normal human hepatocytes, SAMe can selectively induce Bcl-x S , an alternatively spliced isoform of Bcl-x L that promotes apoptosis. This should make SAMe an attractive agent for both chemoprevention and treatment of HCC.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Journal of gastroenterology and hepatology","grobid_abstract_attachment_id":50317929},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356172/S_Adenosylmethionine_in_cell_growth_apoptosis_and_liver_cancer","translated_internal_url":"","created_at":"2013-04-22T04:05:20.243-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317929,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317929/thumbnails/1.jpg","file_name":"S-Adenosylmethionine_in_cell_growth_apop20161115-18932-19lwy8o.pdf","download_url":"https://www.academia.edu/attachments/50317929/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"S_Adenosylmethionine_in_cell_growth_apop.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317929/S-Adenosylmethionine_in_cell_growth_apop20161115-18932-19lwy8o-libre.pdf?1479198395=\u0026response-content-disposition=attachment%3B+filename%3DS_Adenosylmethionine_in_cell_growth_apop.pdf\u0026Expires=1733037244\u0026Signature=Rtun7rGs09yTlAG8iImnZLvUY-v3SiucPYBOqrvvHnBtz5047ap5eh7vCcAPV0zcFhTxrrgpJVjCHh-KJ7KHzOwXkClwdfew1~EmM~OiPimpEXhPYaEb369-vijTjg1wca278kQ1onCNQnrGa3af20FoCMT-zsfTChxhjCEdxD1v6ntQjXwX-N62L8G2-tvI~bdQo--UhHXFQww2BGfPQKO-Epvx5gyRZaU2HayprEPnqpuoO1hz4mWo6-FDMe8~5cqPtCORHdJZteNLjHJnsTIp1TAhlmUh4el~dW-E5Hv6JRKeRGKK~oQUxNGIJhcmJAcCAoU1bCHcAu0Qt~Oohw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"S_Adenosylmethionine_in_cell_growth_apoptosis_and_liver_cancer","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":50317929,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317929/thumbnails/1.jpg","file_name":"S-Adenosylmethionine_in_cell_growth_apop20161115-18932-19lwy8o.pdf","download_url":"https://www.academia.edu/attachments/50317929/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"S_Adenosylmethionine_in_cell_growth_apop.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317929/S-Adenosylmethionine_in_cell_growth_apop20161115-18932-19lwy8o-libre.pdf?1479198395=\u0026response-content-disposition=attachment%3B+filename%3DS_Adenosylmethionine_in_cell_growth_apop.pdf\u0026Expires=1733037244\u0026Signature=Rtun7rGs09yTlAG8iImnZLvUY-v3SiucPYBOqrvvHnBtz5047ap5eh7vCcAPV0zcFhTxrrgpJVjCHh-KJ7KHzOwXkClwdfew1~EmM~OiPimpEXhPYaEb369-vijTjg1wca278kQ1onCNQnrGa3af20FoCMT-zsfTChxhjCEdxD1v6ntQjXwX-N62L8G2-tvI~bdQo--UhHXFQww2BGfPQKO-Epvx5gyRZaU2HayprEPnqpuoO1hz4mWo6-FDMe8~5cqPtCORHdJZteNLjHJnsTIp1TAhlmUh4el~dW-E5Hv6JRKeRGKK~oQUxNGIJhcmJAcCAoU1bCHcAu0Qt~Oohw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":111972,"name":"Hepatocellular Carcinoma","url":"https://www.academia.edu/Documents/in/Hepatocellular_Carcinoma"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":260020,"name":"GASTROENTEROLOGY AND HEPATOLOGY.","url":"https://www.academia.edu/Documents/in/GASTROENTEROLOGY_AND_HEPATOLOGY"},{"id":432593,"name":"Hepatocytes","url":"https://www.academia.edu/Documents/in/Hepatocytes"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":923704,"name":"S-Adenosylmethionine","url":"https://www.academia.edu/Documents/in/S-Adenosylmethionine"},{"id":1954130,"name":"Cell Growth","url":"https://www.academia.edu/Documents/in/Cell_Growth"}],"urls":[{"id":1048275,"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408691/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356170"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356170/Abonos_org%C3%A1nicos_y_su_efecto_en_propiedades_f%C3%ADsicas_y_qu%C3%ADmicas_del_suelo_y_rendimiento_en_ma%C3%ADz"><img alt="Research paper thumbnail of Abonos orgánicos y su efecto en propiedades físicas y químicas del suelo y rendimiento en maíz" class="work-thumbnail" src="https://attachments.academia-assets.com/31165830/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356170/Abonos_org%C3%A1nicos_y_su_efecto_en_propiedades_f%C3%ADsicas_y_qu%C3%ADmicas_del_suelo_y_rendimiento_en_ma%C3%ADz">Abonos orgánicos y su efecto en propiedades físicas y químicas del suelo y rendimiento en maíz</a></div><div class="wp-workCard_item"><span>Terra</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a398554a91bd8c853bc177a905fe43d7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31165830,"asset_id":3356170,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31165830/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356170"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356170"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356170; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356170]").text(description); $(".js-view-count[data-work-id=3356170]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356170; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356170']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356170, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Se desarrolló un trabajo con los siguientes objetivos: a) Evaluar el efecto de los abonos orgánicos sobre propiedades físicas y químicas del suelo y b) Seleccionar el abono orgánico que produzca la mejor respuesta sobre rendimiento de grano. Se evaluaron cuatro tratamientos de abonos orgánicos a dosis de 20, 30 y 40 t ha -1 para bovino, caprino y composta, y 4, 8 y 12 t ha -1 para gallinaza, y un testigo con fertilización inorgánica (120-40-00 de N-P-K). Se utilizó el maíz genotipo San Lorenzo, establecido en un diseño bloques al azar con arreglo factorial A*B con tres repeticiones. Las variables que se evaluaron fueron: contenido de humedad, pH, materia orgánica, N, P y rendimiento de grano. Los resultados indican cambios en las características químicas del suelo (materia orgánica, N y P) antes y después de la siembra. En el caso de características físicas, no existió diferencia significativa. El rendimiento de grano con el tratamiento de fertilización inorgánica 120-40-00 de N-P-K fue el mejor (6.05 t ha -1 ); el abono orgánico de composta (5.66 t ha -1 ) mostró similares resultados. Los abonos orgánicos, principalmente composta con dosis de 20 a 30 t ha -1 , son una alternativa para sustituir a la fertilización inorgánica.","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Terra","grobid_abstract_attachment_id":31165830},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356170/Abonos_org%C3%A1nicos_y_su_efecto_en_propiedades_f%C3%ADsicas_y_qu%C3%ADmicas_del_suelo_y_rendimiento_en_ma%C3%ADz","translated_internal_url":"","created_at":"2013-04-22T04:05:19.555-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":31165830,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/31165830/thumbnails/1.jpg","file_name":"estudiodecasomz.pdf","download_url":"https://www.academia.edu/attachments/31165830/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Abonos_organicos_y_su_efecto_en_propieda.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/31165830/estudiodecasomz-libre.pdf?1392244425=\u0026response-content-disposition=attachment%3B+filename%3DAbonos_organicos_y_su_efecto_en_propieda.pdf\u0026Expires=1733037244\u0026Signature=NmmQNWvDh96CfYHFnHaC6rspTS6v2ZlDXkrQ-RIf1qjtQHIOSy7gKSfuU5jl4Ahup1csDj1kmVLPj5GQsxzYt6NZ3BXAwZd7FaWHpXazMVaGtMn-Tc2KDqpQb6277DPUKb2K36Lnh7UNQ56MKZKB44RQCJB4neViHBf9xudufeKBxU-WxfApDCENr5UzN7~pA4s29y~WiXy1AQ6R5-m~gR6wJSJQGualQh5cAv0VTbTQnFL-y0N4iyFZRepcC9HL5fKkInhCVz0fhRHkfZIUqph3JlNbH2rzdTzWqnqmupBVN600As7lpM65P~QfBkfJWu8ghd~JDCzXpatfiyKP0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Abonos_orgánicos_y_su_efecto_en_propiedades_físicas_y_químicas_del_suelo_y_rendimiento_en_maíz","translated_slug":"","page_count":7,"language":"es","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":31165830,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/31165830/thumbnails/1.jpg","file_name":"estudiodecasomz.pdf","download_url":"https://www.academia.edu/attachments/31165830/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Abonos_organicos_y_su_efecto_en_propieda.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/31165830/estudiodecasomz-libre.pdf?1392244425=\u0026response-content-disposition=attachment%3B+filename%3DAbonos_organicos_y_su_efecto_en_propieda.pdf\u0026Expires=1733037244\u0026Signature=NmmQNWvDh96CfYHFnHaC6rspTS6v2ZlDXkrQ-RIf1qjtQHIOSy7gKSfuU5jl4Ahup1csDj1kmVLPj5GQsxzYt6NZ3BXAwZd7FaWHpXazMVaGtMn-Tc2KDqpQb6277DPUKb2K36Lnh7UNQ56MKZKB44RQCJB4neViHBf9xudufeKBxU-WxfApDCENr5UzN7~pA4s29y~WiXy1AQ6R5-m~gR6wJSJQGualQh5cAv0VTbTQnFL-y0N4iyFZRepcC9HL5fKkInhCVz0fhRHkfZIUqph3JlNbH2rzdTzWqnqmupBVN600As7lpM65P~QfBkfJWu8ghd~JDCzXpatfiyKP0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":494184,"name":"Terra","url":"https://www.academia.edu/Documents/in/Terra"}],"urls":[{"id":1048274,"url":"http://ceuta.org.uy/files/estudiodecasomz.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356169"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356169/Complications_of_laser_dermatologic_surgery"><img alt="Research paper thumbnail of Complications of laser dermatologic surgery" class="work-thumbnail" src="https://attachments.academia-assets.com/50317926/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356169/Complications_of_laser_dermatologic_surgery">Complications of laser dermatologic surgery</a></div><div class="wp-workCard_item"><span>Lasers in surgery …</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="15c73260b671a19b1c12b10dee71633e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317926,"asset_id":3356169,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317926/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356169"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356169"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356169; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356169]").text(description); $(".js-view-count[data-work-id=3356169]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356169; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356169']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356169, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "15c73260b671a19b1c12b10dee71633e" } } $('.js-work-strip[data-work-id=3356169]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356169,"title":"Complications of laser dermatologic surgery","translated_title":"","metadata":{"publisher":"Wiley Online Library","ai_title_tag":"Managing Complications in Laser Dermatologic Surgery","grobid_abstract":"Background and Objective: Innovations in lasers, light and radiofrequency devices have allowed for improved therapeutic efficacy and safety and the ability to treat patients with an ever-increasing number of medical and aesthetic indications. Safety remains a primary concern and the timely communication of complications and their management is vital to insure that treatments be as safe as possible. The purpose of this report on the Proceedings of the First International Laser Surgery Morbidity Meeting is to provide laser experts the opportunity to present and discuss complications that their patients have experienced and how they were successfully managed. Methods: Laser experts were invited to present complications of laser, light, and radiofrequency treatments that their patients have experienced and to discuss the potential mechanisms leading to the complications their management and final outcomes. Results: Nineteen unique cases are presented and the clinical management of each case discussed. Eighteen sets of pre-and post-operative photos are presented. Conclusion: This report shows that even experts, with extensive experience using light-based therapies, can and do have patients who develop complications. Sound clinical judgment, and knowing how to avoid complications and their timely post-operative management, is essential to insure optimal therapeutic outcome.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Lasers in surgery …","grobid_abstract_attachment_id":50317926},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356169/Complications_of_laser_dermatologic_surgery","translated_internal_url":"","created_at":"2013-04-22T04:05:19.151-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317926,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317926/thumbnails/1.jpg","file_name":"Complications_of_laser_dermatologic_surg20161115-18929-dhauh4.pdf","download_url":"https://www.academia.edu/attachments/50317926/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Complications_of_laser_dermatologic_surg.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317926/Complications_of_laser_dermatologic_surg20161115-18929-dhauh4-libre.pdf?1479198396=\u0026response-content-disposition=attachment%3B+filename%3DComplications_of_laser_dermatologic_surg.pdf\u0026Expires=1733037244\u0026Signature=CdQBKJSONedMzw1XmfOI1cSlThhmgdM1XPZy~zfBiTUq2nyBSXw2-0LhD521dABB8ucDcsHYw1eeEbVI6bz4i~c7115s-DXckMBZwV9MOAvei8oEayulPRl-~UVQsUHJsYdgPzohEm1wPxSAFe-B6MXs74Z9ewvRNkaqWuq7XBNZg~cggR3L4v9PoPvd40IKOjD~3RcXCTtGB0VOf2989l0VBmrVf4ehIvthzZ15OGCusVlwU62bGVGkTpBtbnUtLG2Q4GzuQ-6xSJcUymPRVvsDAm1MdAd7scC1GsV8i7EVsw5NChbEn0zRtisFRflGR19F-lhvq1QADW~CyxmOwg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Complications_of_laser_dermatologic_surgery","translated_slug":"","page_count":15,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":50317926,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317926/thumbnails/1.jpg","file_name":"Complications_of_laser_dermatologic_surg20161115-18929-dhauh4.pdf","download_url":"https://www.academia.edu/attachments/50317926/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Complications_of_laser_dermatologic_surg.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317926/Complications_of_laser_dermatologic_surg20161115-18929-dhauh4-libre.pdf?1479198396=\u0026response-content-disposition=attachment%3B+filename%3DComplications_of_laser_dermatologic_surg.pdf\u0026Expires=1733037244\u0026Signature=CdQBKJSONedMzw1XmfOI1cSlThhmgdM1XPZy~zfBiTUq2nyBSXw2-0LhD521dABB8ucDcsHYw1eeEbVI6bz4i~c7115s-DXckMBZwV9MOAvei8oEayulPRl-~UVQsUHJsYdgPzohEm1wPxSAFe-B6MXs74Z9ewvRNkaqWuq7XBNZg~cggR3L4v9PoPvd40IKOjD~3RcXCTtGB0VOf2989l0VBmrVf4ehIvthzZ15OGCusVlwU62bGVGkTpBtbnUtLG2Q4GzuQ-6xSJcUymPRVvsDAm1MdAd7scC1GsV8i7EVsw5NChbEn0zRtisFRflGR19F-lhvq1QADW~CyxmOwg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":39421,"name":"Phototherapy","url":"https://www.academia.edu/Documents/in/Phototherapy"},{"id":49161,"name":"Safety","url":"https://www.academia.edu/Documents/in/Safety"},{"id":229285,"name":"Skin Diseases","url":"https://www.academia.edu/Documents/in/Skin_Diseases"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":591484,"name":"Laser Therapy","url":"https://www.academia.edu/Documents/in/Laser_Therapy"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications"}],"urls":[{"id":1048273,"url":"http://digitalartsph.com/sinpelo/wp-content/uploads/2011/05/Lasers-in-Surgery-and-Medicine-381-15-2006-Complicaciones-Laser.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356168"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356168/Inhibition_of_proliferation_and_induction_of_apoptosis_in_human_breast_cancer_cells_by_lauryl_gallate"><img alt="Research paper thumbnail of Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate" class="work-thumbnail" src="https://attachments.academia-assets.com/50317928/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356168/Inhibition_of_proliferation_and_induction_of_apoptosis_in_human_breast_cancer_cells_by_lauryl_gallate">Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate</a></div><div class="wp-workCard_item"><span>…</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="914fd5de3cd23d36d392eb8ff656cd97" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317928,"asset_id":3356168,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317928/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356168"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356168"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356168; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "914fd5de3cd23d36d392eb8ff656cd97" } } $('.js-work-strip[data-work-id=3356168]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356168,"title":"Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate","translated_title":"","metadata":{"publisher":"Oxford Univ Press","grobid_abstract":"The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression. Studies were performed to determine the effects of a model statin, atorvastatin (ATO), on the proliferation and differentiation of prostate cancer cells, and to identify possible mechanisms of ATO action. ATO inhibited the in vitro proliferation of both LNCaP and PC3 human prostate cancer cells in a dose-and timedependent fashion. The greater inhibitory activity of ATO in PC3 cells was associated with induction of autophagy in that cell line, as demonstrated by increased expression of LC3-II. miR-182 was consistently upregulated by ATO in PC3 cells, but not in LNCaP cells. ATO upregulation of miR-182 in PC3 cells was p53-independent and was reversed by geranylgeraniol. Transfection of miR-182 inhibitors decreased expression of miR-182 by .98% and attenuated the antiproliferative activity of ATO. miR-182 expression in PC3 cells was also increased in response to stress induced by serum withdrawal, suggesting that miR-182 upregulation can occur due to nutritional stress. Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells. Bcl2 was downregulated and p21 was upregulated in PC3 cells exposed to ATO. These data suggest that miR-182 may be a stress-responsive miRNA that mediates ATO action in prostate cancer 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class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356167/Spin_crossover_bistability_in_three_mutually_perpendicular_interpenetrated_4_4_nets">Spin crossover bistability in three mutually perpendicular interpenetrated (4, 4) nets</a></div><div class="wp-workCard_item"><span>Inorganic …</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Sylvie Létard, Xavier Solans, Nieves Menéndez, Antoine Goujon, François Varret, and José Anto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Sylvie Létard, Xavier Solans, Nieves Menéndez, Antoine Goujon, François Varret, and José Antonio Real*. ... Chandrasekar Rajadurai, Frank Schramm, Susan Brink, Olaf Fuhr, Mohamed Ghafari, Robert Kruk, and Mario Ruben. Inorganic Chemistry 2006 45 (25), 10019-10021. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356167"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356167"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356167; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356167]").text(description); $(".js-view-count[data-work-id=3356167]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356167; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356167']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356167, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=3356167]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356167,"title":"Spin crossover bistability in three mutually perpendicular interpenetrated (4, 4) nets","translated_title":"","metadata":{"abstract":"... 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The obtained LDA-based quantitative structure-activity relationships (QSAR) models, using nonstochastic and stochastic indices, were able to classify correctly 87.91% (87.50%) and 89.01% (84.38%) of the chemicals in training (test) sets, respectively. They showed large Matthews correlation coefficients of 0.75 (0.71) and 0.78 (0.65) for the training (test) sets, correspondingly. Later, both models were applied to the virtual screening of 21 chemicals to find new lead antitrichomonal agents. Predictions agreed with experimental results to a great extent because a correct classification for both models of 95.24% (20 of 21) of the chemicals was obtained. Of the 21 compounds that were screened and synthesized, 2 molecules (chemicals G-1, UC-245) showed high to moderate cytocidal activity at the concentration of 10 mg/ml, another 2 compounds (G-0 and CRIS-148) showed high cytocidal activity only at the concentration of 100 mg/ml, and the remaining chemicals (from CRIS-105 to were inactive at these assayed concentrations. Finally, the best candidate, G-1 (cytocidal activity of 100% at 10 mg/ml) was in vivo assayed in ovariectomized Wistar rats achieving promising results as a trichomonacidal drug-like compound. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356165"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356165/Reaction_of_rat_connective_tissue_to_implanted_dentin_tubes_filled_with_a_white_mineral_trioxide_aggregate"><img alt="Research paper thumbnail of Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate" class="work-thumbnail" src="https://attachments.academia-assets.com/50317922/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356165/Reaction_of_rat_connective_tissue_to_implanted_dentin_tubes_filled_with_a_white_mineral_trioxide_aggregate">Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate</a></div><div class="wp-workCard_item"><span>Brazilian Dental …</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="10576b8aad84d48b4ecc27e65b8d855f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317922,"asset_id":3356165,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317922/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356165"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356165"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356165; 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The tubes were implanted into rat subcutaneous tissue and the animals were sacrificed after 7 and 30 days. The undecalcified pieces were prepared for histological analysis with polarized light and von Kossa technique for mineralized tissues. Granulations birefringent to polarized light and an irregular structure like a bridge were observed next to the material; both were von Kossa positive. Also, in the dentin wall tubules a layer of birefringent granulations was observed. The results were similar to those reported for gray MTA, indicating that the mechanisms of action of the white and gray MTA are similar.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Brazilian Dental 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class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356164/Antiprotozoal_activity_of_diamine_derivatives">Antiprotozoal activity of diamine derivatives</a></div><div class="wp-workCard_item"><span>Biomedicine & Pharmacotherapy</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trich...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20μg/mL. N-hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T. vaginalis with MIC of 2.5μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti-G. lamblia activity than MTZ.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356164"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356164"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356164; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356164]").text(description); $(".js-view-count[data-work-id=3356164]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356164; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356164']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356164, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=3356164]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356164,"title":"Antiprotozoal activity of diamine derivatives","translated_title":"","metadata":{"abstract":"Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20μg/mL. N-hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T. vaginalis with MIC of 2.5μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti-G. lamblia activity than MTZ.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Biomedicine \u0026 Pharmacotherapy"},"translated_abstract":"Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20μg/mL. N-hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T. vaginalis with MIC of 2.5μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti-G. lamblia activity than MTZ.","internal_url":"https://www.academia.edu/3356164/Antiprotozoal_activity_of_diamine_derivatives","translated_internal_url":"","created_at":"2013-04-22T04:05:15.025-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antiprotozoal_activity_of_diamine_derivatives","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz","email":"aGIvV2VncVFHZWNWdHUrMGZvc1kxTEpBTVNiMy9YVkZiS2V5RjVkaVBFWT0tLWFSNERPU0hEMFZxU0RGZkxNNXh4UkE9PQ==--caadf2778ca89065ea36ee0a7370e37e2026db14"},"attachments":[],"research_interests":[{"id":131572,"name":"Trichomonas vaginalis","url":"https://www.academia.edu/Documents/in/Trichomonas_vaginalis"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"}],"urls":[{"id":1048270,"url":"http://www.sciencedirect.com/science/article/pii/S0753332210001940"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356163"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356163/Reaction_of_rat_connective_tissue_to_implanted_dentin_tubes_filled_with_mineral_trioxide_aggregate_or_calcium_hydroxide"><img alt="Research paper thumbnail of Reaction of rat connective tissue to implanted dentin tubes filled with mineral trioxide aggregate or calcium hydroxide" class="work-thumbnail" src="https://attachments.academia-assets.com/50317923/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356163/Reaction_of_rat_connective_tissue_to_implanted_dentin_tubes_filled_with_mineral_trioxide_aggregate_or_calcium_hydroxide">Reaction of rat connective tissue to implanted dentin tubes filled with mineral trioxide aggregate or calcium hydroxide</a></div><div class="wp-workCard_item"><span>Braz Dent …</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="deb71ea9dad2426f925a183fe4ec24fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317923,"asset_id":3356163,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317923/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356163"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356163"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356163; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356163]").text(description); $(".js-view-count[data-work-id=3356163]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356163; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356163']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356163, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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The tubes were implanted into rat subcutaneous tissue and the animals were sacrificed after 7 and 30 days. The undecalcified pieces were prepared for histological analysis with polarized light and von Kossa technique for mineralized tissues. Granulations birefringent to polarized light and an irregular structure like a bridge were observed next to the material; both were von Kossa positive. Also, in the dentin wall tubules a layer of birefringent granulations was observed. The results were similar to those reported for gray MTA, indicating that the mechanisms of action of the white and gray MTA are similar.","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Braz Dent 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356162/Investigation_of_lysosomal_storage_diseases_in_nonimmune_hydrops_fetalis">Investigation of lysosomal storage diseases in nonimmune hydrops fetalis</a></div><div class="wp-workCard_item"><span>Prenatal …</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f06761282d7613c84caaecdc9c3bceab" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317931,"asset_id":3356162,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317931/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356161/Comparative_study_of_MTA_and_other_materials_in_retrofilling_of_pulpless_dogs_teeth"><img alt="Research paper thumbnail of Comparative study of MTA and other materials in retrofilling of pulpless dogs' teeth" class="work-thumbnail" src="https://attachments.academia-assets.com/50317925/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356161/Comparative_study_of_MTA_and_other_materials_in_retrofilling_of_pulpless_dogs_teeth">Comparative study of MTA and other materials in retrofilling of pulpless dogs' teeth</a></div><div class="wp-workCard_item"><span>Brazilian Dental …</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This in vivo study compared the effect of mineral trioxide aggregate (MTA), IRM, Super EBA and ZO...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This in vivo study compared the effect of mineral trioxide aggregate (MTA), IRM, Super EBA and ZOE in a puttylike consistency, used as retrofilling materials, in the healing process of periapical tissue of pulpless dogs' teeth submitted to a conventional retrofilling technique. Twenty-four premolars obtained from three dogs were used. At the first intervention, the animals were anesthetized, coronal access was obtained and pulpectomy was done. Root canals were kept open to the oral environment for 180 days to induce the formation of apical lesions. After surgical removal of the lesions with curettes, 2 mm of the apical root was cut out perpendicular to the long axis of the teeth, and root-end cavities were shaped with a low-speed round bur. The bone cavities were irrigated and dried, and the root-end cavities were filled with MTA, IRM, Super EBA and ZOE in a puttylike consistency. The bone cavities were passively filled with blood and flaps were sutured. The coronal access openings were cleaned and double-sealed with ZOE and amalgam. After 180 days, the animals were killed by anesthetic overdose, maxilla and mandible were removed and the pieces were processed for histomorphologic analysis. Data were evaluated blindly on the basis of several histopathologic events and the scores obtained were analyzed statistically using the Kruskal Wallis test. No significant differences were observed among MTA, Super EBA and IRM (p>0.05). However, ZOE had a significantly more negative influence on the apical healing (p<0.05). In conclusion, MTA, Super EBA and IRM had similar histopathologic effects among each other and better performance than ZOE used in a puttylike consistency. Furthermore, only MTA stimulated hard tissue deposition in direct contact with the retrofilling material, even when it was inserted under critical conditions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9aa03f006c50e267d9b59ea7d9111808" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317925,"asset_id":3356161,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317925/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356161; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356161]").text(description); $(".js-view-count[data-work-id=3356161]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356161; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356161']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356161, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9aa03f006c50e267d9b59ea7d9111808" } } $('.js-work-strip[data-work-id=3356161]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356161,"title":"Comparative study of MTA and other materials in retrofilling of pulpless dogs' teeth","translated_title":"","metadata":{"abstract":"This in vivo study compared the effect of mineral trioxide aggregate (MTA), IRM, Super EBA and ZOE in a puttylike consistency, used as retrofilling materials, in the healing process of periapical tissue of pulpless dogs' teeth submitted to a conventional retrofilling technique. Twenty-four premolars obtained from three dogs were used. At the first intervention, the animals were anesthetized, coronal access was obtained and pulpectomy was done. Root canals were kept open to the oral environment for 180 days to induce the formation of apical lesions. After surgical removal of the lesions with curettes, 2 mm of the apical root was cut out perpendicular to the long axis of the teeth, and root-end cavities were shaped with a low-speed round bur. The bone cavities were irrigated and dried, and the root-end cavities were filled with MTA, IRM, Super EBA and ZOE in a puttylike consistency. The bone cavities were passively filled with blood and flaps were sutured. The coronal access openings were cleaned and double-sealed with ZOE and amalgam. After 180 days, the animals were killed by anesthetic overdose, maxilla and mandible were removed and the pieces were processed for histomorphologic analysis. Data were evaluated blindly on the basis of several histopathologic events and the scores obtained were analyzed statistically using the Kruskal Wallis test. No significant differences were observed among MTA, Super EBA and IRM (p\u003e0.05). However, ZOE had a significantly more negative influence on the apical healing (p\u003c0.05). In conclusion, MTA, Super EBA and IRM had similar histopathologic effects among each other and better performance than ZOE used in a puttylike consistency. 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After surgical removal of the lesions with curettes, 2 mm of the apical root was cut out perpendicular to the long axis of the teeth, and root-end cavities were shaped with a low-speed round bur. The bone cavities were irrigated and dried, and the root-end cavities were filled with MTA, IRM, Super EBA and ZOE in a puttylike consistency. The bone cavities were passively filled with blood and flaps were sutured. The coronal access openings were cleaned and double-sealed with ZOE and amalgam. After 180 days, the animals were killed by anesthetic overdose, maxilla and mandible were removed and the pieces were processed for histomorphologic analysis. Data were evaluated blindly on the basis of several histopathologic events and the scores obtained were analyzed statistically using the Kruskal Wallis test. No significant differences were observed among MTA, Super EBA and IRM (p\u003e0.05). However, ZOE had a significantly more negative influence on the apical healing (p\u003c0.05). 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hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356159/Removal_of_an_emerging_pharmaceutical_compound_by_adsorption_in_fixed_bed_column"><img alt="Research paper thumbnail of Removal of an emerging pharmaceutical compound by adsorption in fixed bed column" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356159/Removal_of_an_emerging_pharmaceutical_compound_by_adsorption_in_fixed_bed_column">Removal of an emerging pharmaceutical compound by adsorption in fixed bed column</a></div><div class="wp-workCard_item"><span>Desalination and Water Treatment</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adsorption of atenolol on granular activated carbon in a fixed bed column was investigated. This ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adsorption of atenolol on granular activated carbon in a fixed bed column was investigated. This micropollutant was effectively adsorbed onto the activated carbon; therefore, the effect of some operation parameters on the performance of the breakthrough curve was studied. Some adsorption parameters, as the adsorption capacities at breakthrough and saturation time, the length of the mass transfer zone (mtz) and the fractional bed utilization were estimated. Four kinetic models, including Adams–Bohart, Wolborska, Thomas, and Yoon–Nelson model, were used to determine the adsorption parameters and to predict the breakthrough curves. Among all examined models, Thomas and Yoon–Nelson were found to be the most suitable for simulation of the breakthrough curve of atenolol uptake on granular activated carbon fixed bed column.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356159"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356159]").text(description); $(".js-view-count[data-work-id=3356159]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356159']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356159, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=3356159]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356159,"title":"Removal of an emerging pharmaceutical compound by adsorption in fixed bed column","translated_title":"","metadata":{"abstract":"Adsorption of atenolol on granular activated carbon in a fixed bed column was investigated. This micropollutant was effectively adsorbed onto the activated carbon; therefore, the effect of some operation parameters on the performance of the breakthrough curve was studied. Some adsorption parameters, as the adsorption capacities at breakthrough and saturation time, the length of the mass transfer zone (mtz) and the fractional bed utilization were estimated. Four kinetic models, including Adams–Bohart, Wolborska, Thomas, and Yoon–Nelson model, were used to determine the adsorption parameters and to predict the breakthrough curves. Among all examined models, Thomas and Yoon–Nelson were found to be the most suitable for simulation of the breakthrough curve of atenolol uptake on granular activated carbon fixed bed column.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Desalination and Water Treatment"},"translated_abstract":"Adsorption of atenolol on granular activated carbon in a fixed bed column was investigated. This micropollutant was effectively adsorbed onto the activated carbon; therefore, the effect of some operation parameters on the performance of the breakthrough curve was studied. Some adsorption parameters, as the adsorption capacities at breakthrough and saturation time, the length of the mass transfer zone (mtz) and the fractional bed utilization were estimated. Four kinetic models, including Adams–Bohart, Wolborska, Thomas, and Yoon–Nelson model, were used to determine the adsorption parameters and to predict the breakthrough curves. Among all examined models, Thomas and Yoon–Nelson were found to be the most suitable for simulation of the breakthrough curve of atenolol uptake on granular activated carbon fixed bed column.","internal_url":"https://www.academia.edu/3356159/Removal_of_an_emerging_pharmaceutical_compound_by_adsorption_in_fixed_bed_column","translated_internal_url":"","created_at":"2013-04-22T04:05:09.329-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Removal_of_an_emerging_pharmaceutical_compound_by_adsorption_in_fixed_bed_column","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[],"research_interests":[{"id":55,"name":"Environmental Engineering","url":"https://www.academia.edu/Documents/in/Environmental_Engineering"},{"id":72,"name":"Chemical Engineering","url":"https://www.academia.edu/Documents/in/Chemical_Engineering"},{"id":73,"name":"Civil Engineering","url":"https://www.academia.edu/Documents/in/Civil_Engineering"},{"id":2024,"name":"Mass Transfer","url":"https://www.academia.edu/Documents/in/Mass_Transfer"},{"id":39752,"name":"Adsorption","url":"https://www.academia.edu/Documents/in/Adsorption"},{"id":39753,"name":"Activated Carbon","url":"https://www.academia.edu/Documents/in/Activated_Carbon"},{"id":65757,"name":"Wastewater","url":"https://www.academia.edu/Documents/in/Wastewater"},{"id":291387,"name":"Mathematical Model","url":"https://www.academia.edu/Documents/in/Mathematical_Model"},{"id":835697,"name":"Lumping Kinetic Model","url":"https://www.academia.edu/Documents/in/Lumping_Kinetic_Model"},{"id":1137336,"name":"Granular Activated Carbon","url":"https://www.academia.edu/Documents/in/Granular_Activated_Carbon"},{"id":1434580,"name":"Breakthrough Curve","url":"https://www.academia.edu/Documents/in/Breakthrough_Curve"}],"urls":[{"id":1048267,"url":"http://dx.doi.org/10.1080/19443994.2012.692062"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356158/DNA_sequence_analysis_of_rdxA_and_frxA_from_paired_metronidazole_sensitive_and_resistant_Helicobacter_pylori_isolates_obtained_from_patients_with_heteroresistance"><img alt="Research paper thumbnail of DNA sequence analysis of rdxA and frxA from paired metronidazole-sensitive and -resistant Helicobacter pylori isolates obtained from patients with heteroresistance" class="work-thumbnail" src="https://attachments.academia-assets.com/50317932/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356158/DNA_sequence_analysis_of_rdxA_and_frxA_from_paired_metronidazole_sensitive_and_resistant_Helicobacter_pylori_isolates_obtained_from_patients_with_heteroresistance">DNA sequence analysis of rdxA and frxA from paired metronidazole-sensitive and -resistant Helicobacter pylori isolates obtained from patients with heteroresistance</a></div><div class="wp-workCard_item"><span>International Journal of Antimicrobial Agents</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8576dfe284153e3edc29851ace84effe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317932,"asset_id":3356158,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317932/download_file?st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356158; 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The paired strains from each single biopsy had identical lspA-glmM restriction fragment length polymorphism profiles, and the differences in MTZ susceptibility were mostly accounted for by mutations in the rdxA gene. Truncation of RdxA is associated with a minimum inhibitory concentration of 64-128 mg/L. Early truncation of FrxA was observed both in susceptible and resistant isolates of seven paired strains. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356157"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356157/Arsenic_release_provided_by_MTA_and_Portland_cement"><img alt="Research paper thumbnail of Arsenic release provided by MTA and Portland cement" class="work-thumbnail" src="https://attachments.academia-assets.com/31165827/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356157/Arsenic_release_provided_by_MTA_and_Portland_cement">Arsenic release provided by MTA and Portland cement</a></div><div class="wp-workCard_item"><span>Oral Surgery, Oral …</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5bf83b3f0ad315ad3d52485bdbe6136b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31165827,"asset_id":3356157,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31165827/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356157"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356157"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356157; 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356156]").text(description); $(".js-view-count[data-work-id=3356156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356156, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Pimonidazole hydrochloride (Hypoxyprobe) is an imaging agent that is bioreductively activated only under hypoxic conditions in mammalian tissue. We employed this probe to evaluate the oxygen tension in tuberculous granulomas in four animal models of disease: mouse, guinea pig, rabbit, and nonhuman primate. Following infusion of pimonidazole into animals with established infections, lung tissues from the guinea pig, rabbit, and nonhuman primate showed discrete areas of pimonidazole adduct formation surrounding necrotic and caseous regions of pulmonary granulomas by immunohistochemical staining. This labeling could be substantially reduced by housing the animal under an atmosphere of 95% O 2 . Direct measurement of tissue oxygen partial pressure by surgical insertion of a fiber optic oxygen probe into granulomas in the lungs of living infected rabbits demonstrated that even small (3-mm) pulmonary lesions were severely hypoxic (1.6 ؎ 0.7 mm Hg). Finally, metronidazole, which has potent bactericidal activity in vitro only under low-oxygen culture conditions, was highly effective at reducing total-lung bacterial burdens in infected rabbits. Thus, three independent lines of evidence support the hypothesis that hypoxic microenvironments are an important feature of some lesions in these animal models of tuberculosis.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Infection and 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</script> <div class="js-work-strip profile--work_container" data-work-id="3356154"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356154/Bond_based_linear_indices_in_QSAR_computational_discovery_of_novel_anti_trichomonal_compounds"><img alt="Research paper thumbnail of Bond-based linear indices in QSAR: computational discovery of novel anti-trichomonal compounds" class="work-thumbnail" src="https://attachments.academia-assets.com/50317933/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356154/Bond_based_linear_indices_in_QSAR_computational_discovery_of_novel_anti_trichomonal_compounds">Bond-based linear indices in QSAR: computational discovery of novel anti-trichomonal compounds</a></div><div class="wp-workCard_item"><span>Journal of Computer-aided Molecular Design</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Trichomonas vaginalis (Tv) is the causative agent of the most common, non-viral, sexually transmi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Trichomonas vaginalis (Tv) is the causative agent of the most common, non-viral, sexually transmitted disease in women and men worldwide. Since 1959, metronidazole (MTZ) has been the drug of choice in the systemic treatment of trichomoniasis. However, resistance to MTZ in some patients and the great cost associated with the development of new trichomonacidals make necessary the development of computational methods that shorten the drug discovery pipeline. Toward this end, bond-based linear indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis were used to discover novel trichomonacidal chemicals. The obtained models, using non-stochastic and stochastic indices, are able to classify correctly 89.01% (87.50%) and 82.42% (84.38%) of the chemicals in the training (test) sets, respectively. These results validate the models for their use in the ligand-based virtual screening. In addition, they show large Matthews’ correlation coefficients (C) of 0.78 (0.71) and 0.65 (0.65) for the training (test) sets, correspondingly. The result of predictions on the 10% full-out cross-validation test also evidences the robustness of the obtained models. Later, both models are applied to the virtual screening of 12 compounds already proved against Tv. As a result, they correctly classify 10 out of 12 (83.33%) and 9 out of 12 (75.00%) of the chemicals, respectively; which is the most important criterion for validating the models. Besides, these classification functions are applied to a library of seven chemicals in order to find novel antitrichomonal agents. These compounds are synthesized and tested for in vitro activity against Tv. As a result, experimental observations approached to theoretical predictions, since it was obtained a correct classification of 85.71% (6 out of 7) of the chemicals. Moreover, out of the seven compounds that are screened, synthesized and biologically assayed, six compounds (VA7-34, VA7-35, VA7-37, VA7-38, VA7-68, VA7-70) show pronounced cytocidal activity at the concentration of 100 μg/ml at 24 h (48 h) within the range of 98.66%–100% (99.40%–100%), while only two molecules (chemicals VA7-37 and VA7-38) show high cytocidal activity at the concentration of 10 μg/ml at 24 h (48 h): 98.38% (94.23%) and 97.59% (98.10%), correspondingly. The LDA-assisted QSAR models presented here could significantly reduce the number of synthesized and tested compounds and could increase the chance of finding new chemical entities with anti-trichomonal activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="543a687de8d4aa8b2b443704b0778c9a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317933,"asset_id":3356154,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317933/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356154"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356154"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356154; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356154]").text(description); $(".js-view-count[data-work-id=3356154]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356154; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356154']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356154, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "543a687de8d4aa8b2b443704b0778c9a" } } $('.js-work-strip[data-work-id=3356154]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356154,"title":"Bond-based linear indices in QSAR: computational discovery of novel anti-trichomonal compounds","translated_title":"","metadata":{"abstract":"Trichomonas vaginalis (Tv) is the causative agent of the most common, non-viral, sexually transmitted disease in women and men worldwide. Since 1959, metronidazole (MTZ) has been the drug of choice in the systemic treatment of trichomoniasis. However, resistance to MTZ in some patients and the great cost associated with the development of new trichomonacidals make necessary the development of computational methods that shorten the drug discovery pipeline. Toward this end, bond-based linear indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis were used to discover novel trichomonacidal chemicals. The obtained models, using non-stochastic and stochastic indices, are able to classify correctly 89.01% (87.50%) and 82.42% (84.38%) of the chemicals in the training (test) sets, respectively. These results validate the models for their use in the ligand-based virtual screening. In addition, they show large Matthews’ correlation coefficients (C) of 0.78 (0.71) and 0.65 (0.65) for the training (test) sets, correspondingly. The result of predictions on the 10% full-out cross-validation test also evidences the robustness of the obtained models. Later, both models are applied to the virtual screening of 12 compounds already proved against Tv. As a result, they correctly classify 10 out of 12 (83.33%) and 9 out of 12 (75.00%) of the chemicals, respectively; which is the most important criterion for validating the models. Besides, these classification functions are applied to a library of seven chemicals in order to find novel antitrichomonal agents. These compounds are synthesized and tested for in vitro activity against Tv. As a result, experimental observations approached to theoretical predictions, since it was obtained a correct classification of 85.71% (6 out of 7) of the chemicals. Moreover, out of the seven compounds that are screened, synthesized and biologically assayed, six compounds (VA7-34, VA7-35, VA7-37, VA7-38, VA7-68, VA7-70) show pronounced cytocidal activity at the concentration of 100 μg/ml at 24 h (48 h) within the range of 98.66%–100% (99.40%–100%), while only two molecules (chemicals VA7-37 and VA7-38) show high cytocidal activity at the concentration of 10 μg/ml at 24 h (48 h): 98.38% (94.23%) and 97.59% (98.10%), correspondingly. The LDA-assisted QSAR models presented here could significantly reduce the number of synthesized and tested compounds and could increase the chance of finding new chemical entities with anti-trichomonal activity.","ai_title_tag":"Computational Discovery of Novel Anti-Trichomonal Compounds","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Journal of Computer-aided Molecular Design"},"translated_abstract":"Trichomonas vaginalis (Tv) is the causative agent of the most common, non-viral, sexually transmitted disease in women and men worldwide. Since 1959, metronidazole (MTZ) has been the drug of choice in the systemic treatment of trichomoniasis. However, resistance to MTZ in some patients and the great cost associated with the development of new trichomonacidals make necessary the development of computational methods that shorten the drug discovery pipeline. Toward this end, bond-based linear indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis were used to discover novel trichomonacidal chemicals. The obtained models, using non-stochastic and stochastic indices, are able to classify correctly 89.01% (87.50%) and 82.42% (84.38%) of the chemicals in the training (test) sets, respectively. These results validate the models for their use in the ligand-based virtual screening. In addition, they show large Matthews’ correlation coefficients (C) of 0.78 (0.71) and 0.65 (0.65) for the training (test) sets, correspondingly. The result of predictions on the 10% full-out cross-validation test also evidences the robustness of the obtained models. Later, both models are applied to the virtual screening of 12 compounds already proved against Tv. As a result, they correctly classify 10 out of 12 (83.33%) and 9 out of 12 (75.00%) of the chemicals, respectively; which is the most important criterion for validating the models. Besides, these classification functions are applied to a library of seven chemicals in order to find novel antitrichomonal agents. These compounds are synthesized and tested for in vitro activity against Tv. As a result, experimental observations approached to theoretical predictions, since it was obtained a correct classification of 85.71% (6 out of 7) of the chemicals. Moreover, out of the seven compounds that are screened, synthesized and biologically assayed, six compounds (VA7-34, VA7-35, VA7-37, VA7-38, VA7-68, VA7-70) show pronounced cytocidal activity at the concentration of 100 μg/ml at 24 h (48 h) within the range of 98.66%–100% (99.40%–100%), while only two molecules (chemicals VA7-37 and VA7-38) show high cytocidal activity at the concentration of 10 μg/ml at 24 h (48 h): 98.38% (94.23%) and 97.59% (98.10%), correspondingly. The LDA-assisted QSAR models presented here could significantly reduce the number of synthesized and tested compounds and could increase the chance of finding new chemical entities with anti-trichomonal activity.","internal_url":"https://www.academia.edu/3356154/Bond_based_linear_indices_in_QSAR_computational_discovery_of_novel_anti_trichomonal_compounds","translated_internal_url":"","created_at":"2013-04-22T04:05:02.714-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317933,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317933/thumbnails/1.jpg","file_name":"s10822-008-9171-120161115-18925-14rgog.pdf","download_url":"https://www.academia.edu/attachments/50317933/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bond_based_linear_indices_in_QSAR_comput.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317933/s10822-008-9171-120161115-18925-14rgog-libre.pdf?1479198394=\u0026response-content-disposition=attachment%3B+filename%3DBond_based_linear_indices_in_QSAR_comput.pdf\u0026Expires=1732980114\u0026Signature=YF~YK2I4CC~zfI-N3oHSVKtZdCHzSvtMbdmUP-sjArOTPVBUT-tDxkhXfCF2Z~dLx8QKVuzig3EJM-L46bXhvSmCGcf1rcGLpNQ7OsipEqsrapnpe30djb9P0DCs7181DcbbNatm9n07MGfqZj5EUNrLLnuIsuIgLQNUg0mqK9sqyV3rnbDi1xVJ1Ym60Uc0f2eUOT6dll-Hf21ZwZilCk1NQvYvY71p6sWN-whCP9HqXI4IbTGiuDsbe4jz2I6uTXVNDyBEEh2gb17t7EAAInZMZphZFcsEqVerB-kZq2XKHU0X3vubDPHHvlTIjOAI1dn36ywqI05Xg7lgcdkLJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bond_based_linear_indices_in_QSAR_computational_discovery_of_novel_anti_trichomonal_compounds","translated_slug":"","page_count":18,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356153/Assessment_of_fetal_risk_associated_with_exposure_to_cancer_chemotherapy_during_pregnancy_a_multicenter_study"><img alt="Research paper thumbnail of Assessment of fetal risk associated with exposure to cancer chemotherapy during pregnancy: a multicenter study" class="work-thumbnail" src="https://attachments.academia-assets.com/50317936/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356153/Assessment_of_fetal_risk_associated_with_exposure_to_cancer_chemotherapy_during_pregnancy_a_multicenter_study">Assessment of fetal risk associated with exposure to cancer chemotherapy during pregnancy: a multicenter study</a></div><div class="wp-workCard_item"><span>Brazilian journal of …</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fdebe9cadf7df73b226d88d808033b58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317936,"asset_id":3356153,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317936/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356153"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div 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{"id":3356153,"title":"Assessment of fetal risk associated with exposure to cancer chemotherapy during pregnancy: a multicenter study","translated_title":"","metadata":{"publisher":"SciELO Brasil","ai_title_tag":"Fetal Risks of Cancer Chemotherapy During Pregnancy","grobid_abstract":"The objective of the present study was to evaluate and quantify fetal risks involved in the administration of cancer chemotherapy during gestation, as well as to assess the long-term effects on the exposed children. In this retrospective, cohort study, we reviewed the records of women aged 15 to 45 years with a diagnosis of malignancy or benign tumors with malignant behavior at three reference services in the State of Rio Grande do Sul, Brazil, from 1990 to 1997. All patients with a diagnosis of pregnancy at any time during the course of the disease were selected, regardless of whether or not they received specific medication. Fetal outcomes of 14 pregnancies with chemotherapy exposure were compared to that of 15 control pregnancies in which these drugs were not used. Long-term follow-up of the exposed children was carried out. Fisher's exact test was used to compare the groups. Continuous variables were compared by the Wilcoxon-Mann-Whitney test. We found an increased rate of prematurity (6/8 vs 2/10; RR: 3.75; CI: 1.02-13.8; P = 0.03) in the exposed group. There was a trend to an increased fetal death rate (4/12 vs 0/10; P = 0.07) in the group exposed to chemotherapy. No malformations were detected in any child, which can be related to our small sample size as well as to the fact that most exposures occurred after the first trimester of pregnancy. Other larger, controlled studies are needed to establish the actual risk related to cancer chemotherapy during pregnancy.","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Brazilian journal of …","grobid_abstract_attachment_id":50317936},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356153/Assessment_of_fetal_risk_associated_with_exposure_to_cancer_chemotherapy_during_pregnancy_a_multicenter_study","translated_internal_url":"","created_at":"2013-04-22T04:05:01.898-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317936,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317936/thumbnails/1.jpg","file_name":"Assessment_of_fetal_risk_associated_with20161115-18929-89z8wz.pdf","download_url":"https://www.academia.edu/attachments/50317936/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Assessment_of_fetal_risk_associated_with.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317936/Assessment_of_fetal_risk_associated_with20161115-18929-89z8wz-libre.pdf?1479198391=\u0026response-content-disposition=attachment%3B+filename%3DAssessment_of_fetal_risk_associated_with.pdf\u0026Expires=1733037245\u0026Signature=Jj-1oGcid9Rm-eQuzVMlEW~OXWFOnjPiXqEs2jmP9AxQo8aPUJiRs3kJCcxnJC3H7XMUpYrBZYwuSGEEBpgVILFvrwj9DnxMy2nfnMVvh2P~HiaA1qub~Vv1CHKlLgZ8UwOQEsmMKd4aa6EcqOPKLBf57fGryckvycuHsFWuD0ZppZK68-JMF901BJtEM9RAbtVCQ-IT6CME2HRjA~6LptoKKTLDK-e1wKz2SERil3qpQFCBwzNYyTXPErtXH2~ltdFgN-HDWoI6CTKRVKt79b~PYwzUnKDhSizUsuzYMhUhdVmQMXaajMUy8rN4GmPnBR18LqhDj1b9jOpeLlP7Iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Assessment_of_fetal_risk_associated_with_exposure_to_cancer_chemotherapy_during_pregnancy_a_multicenter_study","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":50317936,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317936/thumbnails/1.jpg","file_name":"Assessment_of_fetal_risk_associated_with20161115-18929-89z8wz.pdf","download_url":"https://www.academia.edu/attachments/50317936/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Assessment_of_fetal_risk_associated_with.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317936/Assessment_of_fetal_risk_associated_with20161115-18929-89z8wz-libre.pdf?1479198391=\u0026response-content-disposition=attachment%3B+filename%3DAssessment_of_fetal_risk_associated_with.pdf\u0026Expires=1733037245\u0026Signature=Jj-1oGcid9Rm-eQuzVMlEW~OXWFOnjPiXqEs2jmP9AxQo8aPUJiRs3kJCcxnJC3H7XMUpYrBZYwuSGEEBpgVILFvrwj9DnxMy2nfnMVvh2P~HiaA1qub~Vv1CHKlLgZ8UwOQEsmMKd4aa6EcqOPKLBf57fGryckvycuHsFWuD0ZppZK68-JMF901BJtEM9RAbtVCQ-IT6CME2HRjA~6LptoKKTLDK-e1wKz2SERil3qpQFCBwzNYyTXPErtXH2~ltdFgN-HDWoI6CTKRVKt79b~PYwzUnKDhSizUsuzYMhUhdVmQMXaajMUy8rN4GmPnBR18LqhDj1b9jOpeLlP7Iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":163353,"name":"Cancer Chemotherapy","url":"https://www.academia.edu/Documents/in/Cancer_Chemotherapy"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":483419,"name":"Brazilian","url":"https://www.academia.edu/Documents/in/Brazilian"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":797418,"name":"Gestational Age","url":"https://www.academia.edu/Documents/in/Gestational_Age"},{"id":1179060,"name":"Fetal death","url":"https://www.academia.edu/Documents/in/Fetal_death"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents"},{"id":1711123,"name":"Apgar Score","url":"https://www.academia.edu/Documents/in/Apgar_Score"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"}],"urls":[{"id":1048261,"url":"http://www.scielo.br/scielo.php?pid=S0100-879X2001001200007\u0026script=sci_arttext"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356152"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356152/Unsuspected_and_extensive_transmission_of_a_drug_susceptible_Mycobacterium_tuberculosis_strain"><img alt="Research paper thumbnail of Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain" class="work-thumbnail" src="https://attachments.academia-assets.com/50317930/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356152/Unsuspected_and_extensive_transmission_of_a_drug_susceptible_Mycobacterium_tuberculosis_strain">Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain</a></div><div class="wp-workCard_item"><span>BMC Pulmonary Medicine</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tube...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004. Methods The Mycobacterium tuberculosis drug-susceptible strain, named MTZ strain, was genetically characterized by IS6110-RFLP, Spoligotyping and by MIRU-VNTR typing and the genetic patterns obtained were compared with those included in international databases. The characteristics of the affected patients, in an attempt to understand why the MTZ strain was so highly transmitted among the population were also analyzed. Results The genetic profile of the MTZ strain was rare and not widely distributed in our area or elsewhere. The patients affected did not show any notable risk factor for TB. Conclusion The M. tuberculosis strain MTZ, might have particular transmissibility or virulence properties, and we believe that greater focus should be placed on stopping its widespread dissemination.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9f676a3fc71c111b8954c7fcf626df4d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317930,"asset_id":3356152,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317930/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356152"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356152"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356152; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356152]").text(description); $(".js-view-count[data-work-id=3356152]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356152; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356152']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356152, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9f676a3fc71c111b8954c7fcf626df4d" } } $('.js-work-strip[data-work-id=3356152]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356152,"title":"Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain","translated_title":"","metadata":{"abstract":"Background A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004. Methods The Mycobacterium tuberculosis drug-susceptible strain, named MTZ strain, was genetically characterized by IS6110-RFLP, Spoligotyping and by MIRU-VNTR typing and the genetic patterns obtained were compared with those included in international databases. The characteristics of the affected patients, in an attempt to understand why the MTZ strain was so highly transmitted among the population were also analyzed. Results The genetic profile of the MTZ strain was rare and not widely distributed in our area or elsewhere. The patients affected did not show any notable risk factor for TB. Conclusion The M. tuberculosis strain MTZ, might have particular transmissibility or virulence properties, and we believe that greater focus should be placed on stopping its widespread dissemination.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"BMC Pulmonary Medicine"},"translated_abstract":"Background A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004. Methods The Mycobacterium tuberculosis drug-susceptible strain, named MTZ strain, was genetically characterized by IS6110-RFLP, Spoligotyping and by MIRU-VNTR typing and the genetic patterns obtained were compared with those included in international databases. The characteristics of the affected patients, in an attempt to understand why the MTZ strain was so highly transmitted among the population were also analyzed. Results The genetic profile of the MTZ strain was rare and not widely distributed in our area or elsewhere. The patients affected did not show any notable risk factor for TB. Conclusion The M. tuberculosis strain MTZ, might have particular transmissibility or virulence properties, and we believe that greater focus should be placed on stopping its widespread dissemination.","internal_url":"https://www.academia.edu/3356152/Unsuspected_and_extensive_transmission_of_a_drug_susceptible_Mycobacterium_tuberculosis_strain","translated_internal_url":"","created_at":"2013-04-22T04:05:01.226-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317930,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317930/thumbnails/1.jpg","file_name":"1471-2466-9-3.pdf","download_url":"https://www.academia.edu/attachments/50317930/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Unsuspected_and_extensive_transmission_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317930/1471-2466-9-3-libre.pdf?1479198397=\u0026response-content-disposition=attachment%3B+filename%3DUnsuspected_and_extensive_transmission_o.pdf\u0026Expires=1733037245\u0026Signature=CGpNB9p8gyDKnnzr4ohBbXstbeZtUMuFT91EDbHvkkH~NHi8Hg1mLgrcBvzPyL3Yu1PgDk0DEQQDIxP0DrNmwtrFpwX8L5S039yzpLja4Q8KZkTdDfjtuc9EL49PzsYnFtpKyDzVE1sp463G56-1vmMy~QxJug9BEoPnqd14konmi6gJb~PQ0zpP2VbKniS9bVBtdLLdQcxQ8Y4z-yH~Jmrq9oJArYr76BVLtK8dc3kxegrjWPncFRH-qP8-uBVRFCpbWBMdZDPWwmVjuhhu3uucSU4Q3BBOD3lWgZmGMpb69oZrK7Y4Copf-Uf2XdO3MdY9WUbYnilCcqkpfx2xPw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Unsuspected_and_extensive_transmission_of_a_drug_susceptible_Mycobacterium_tuberculosis_strain","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":50317930,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317930/thumbnails/1.jpg","file_name":"1471-2466-9-3.pdf","download_url":"https://www.academia.edu/attachments/50317930/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Unsuspected_and_extensive_transmission_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317930/1471-2466-9-3-libre.pdf?1479198397=\u0026response-content-disposition=attachment%3B+filename%3DUnsuspected_and_extensive_transmission_o.pdf\u0026Expires=1733037245\u0026Signature=CGpNB9p8gyDKnnzr4ohBbXstbeZtUMuFT91EDbHvkkH~NHi8Hg1mLgrcBvzPyL3Yu1PgDk0DEQQDIxP0DrNmwtrFpwX8L5S039yzpLja4Q8KZkTdDfjtuc9EL49PzsYnFtpKyDzVE1sp463G56-1vmMy~QxJug9BEoPnqd14konmi6gJb~PQ0zpP2VbKniS9bVBtdLLdQcxQ8Y4z-yH~Jmrq9oJArYr76BVLtK8dc3kxegrjWPncFRH-qP8-uBVRFCpbWBMdZDPWwmVjuhhu3uucSU4Q3BBOD3lWgZmGMpb69oZrK7Y4Copf-Uf2XdO3MdY9WUbYnilCcqkpfx2xPw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":40516,"name":"Spain","url":"https://www.academia.edu/Documents/in/Spain"},{"id":43665,"name":"Molecular Epidemiology","url":"https://www.academia.edu/Documents/in/Molecular_Epidemiology"},{"id":57907,"name":"Disease Outbreaks","url":"https://www.academia.edu/Documents/in/Disease_Outbreaks"},{"id":62235,"name":"Tuberculosis","url":"https://www.academia.edu/Documents/in/Tuberculosis"},{"id":68318,"name":"Mycobacterium tuberculosis","url":"https://www.academia.edu/Documents/in/Mycobacterium_tuberculosis"},{"id":96047,"name":"Case Study","url":"https://www.academia.edu/Documents/in/Case_Study"},{"id":134041,"name":"DNA fingerprinting","url":"https://www.academia.edu/Documents/in/DNA_fingerprinting"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":1036777,"name":"Epidemiologic Studies","url":"https://www.academia.edu/Documents/in/Epidemiologic_Studies"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool"}],"urls":[{"id":1048260,"url":"http://www.springerlink.com/index/rp9364h04247w741.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356151"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356151/REPARACI%C3%93N_Y_TECNOLOG%C3%8DA_MEC%C3%81NICA_REPAIRING_AND_MECHANICAL_TECHNOLOGY"><img alt="Research paper thumbnail of REPARACIÓN Y TECNOLOGÍA MECÁNICA REPAIRING AND MECHANICAL TECHNOLOGY" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356151/REPARACI%C3%93N_Y_TECNOLOG%C3%8DA_MEC%C3%81NICA_REPAIRING_AND_MECHANICAL_TECHNOLOGY">REPARACIÓN Y TECNOLOGÍA MECÁNICA REPAIRING AND MECHANICAL TECHNOLOGY</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... DE LA RESISTENCIA AL DESGASTE DE APEROS MEDIANTE LA APLICACIÓN DEL RECARGUE SUPERFICIAL POR S...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... DE LA RESISTENCIA AL DESGASTE DE APEROS MEDIANTE LA APLICACIÓN DEL RECARGUE SUPERFICIAL POR SOLDADURA AUTOMÁTICA Elvis López B ... DE BIOMASA EN EL PROCESO DE SECADO AGROINDUSTRIAL Alain Ariel de la Rosa Andino /Luis Zamora ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356151"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356151"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356151; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356151]").text(description); $(".js-view-count[data-work-id=3356151]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356151; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356151']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356151, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=3356151]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356151,"title":"REPARACIÓN Y TECNOLOGÍA MECÁNICA REPAIRING AND MECHANICAL TECHNOLOGY","translated_title":"","metadata":{"abstract":"... DE LA RESISTENCIA AL DESGASTE DE APEROS MEDIANTE LA APLICACIÓN DEL RECARGUE SUPERFICIAL POR SOLDADURA AUTOMÁTICA Elvis López B ... DE BIOMASA EN EL PROCESO DE SECADO AGROINDUSTRIAL Alain Ariel de la Rosa Andino /Luis Zamora ...","publication_date":{"day":null,"month":null,"year":2005,"errors":{}}},"translated_abstract":"... DE LA RESISTENCIA AL DESGASTE DE APEROS MEDIANTE LA APLICACIÓN DEL RECARGUE SUPERFICIAL POR SOLDADURA AUTOMÁTICA Elvis López B ... DE BIOMASA EN EL PROCESO DE SECADO AGROINDUSTRIAL Alain Ariel de la Rosa Andino /Luis Zamora ...","internal_url":"https://www.academia.edu/3356151/REPARACI%C3%93N_Y_TECNOLOG%C3%8DA_MEC%C3%81NICA_REPAIRING_AND_MECHANICAL_TECHNOLOGY","translated_internal_url":"","created_at":"2013-04-22T04:04:59.730-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"REPARACIÓN_Y_TECNOLOGÍA_MECÁNICA_REPAIRING_AND_MECHANICAL_TECHNOLOGY","translated_slug":"","page_count":null,"language":"hr","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz","email":"MXdvbWZvMGo0Vm91bzl1cE5yWTVvOU9LSXg1ZlNaUDVHVHVOSjBnUmdybz0tLXlDRkRUTWdjVW5QdExDTjVEbUZleHc9PQ==--7551d9ea79adea770afdf5ad209ddd7d6a9edb0a"},"attachments":[],"research_interests":[],"urls":[{"id":1048259,"url":"http://redalyc.uaemex.mx/redalyc/pdf/932/93214206.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356150"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356150/DNA_sequence_analysis_of_i_rdxA_i_and_i_frxA_i_from_paired_metronidazole_sensitive_and_resistant_i_Helicobacter_pylori_i_isolates_obtained_from_patients_"><img alt="Research paper thumbnail of DNA sequence analysis of< i> rdxA</i> and< i> frxA</i> from paired metronidazole-sensitive and-resistant< i> Helicobacter pylori</i> isolates obtained from patients …" class="work-thumbnail" src="https://attachments.academia-assets.com/50317935/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356150/DNA_sequence_analysis_of_i_rdxA_i_and_i_frxA_i_from_paired_metronidazole_sensitive_and_resistant_i_Helicobacter_pylori_i_isolates_obtained_from_patients_">DNA sequence analysis of< i> rdxA</i> and< i> frxA</i> from paired metronidazole-sensitive and-resistant< i> Helicobacter pylori</i> isolates obtained from patients …</a></div><div class="wp-workCard_item"><span>International journal of …</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="42c633f782fc7de75f928c2b5ece9224" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317935,"asset_id":3356150,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317935/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356150"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356150"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356150; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "42c633f782fc7de75f928c2b5ece9224" } } $('.js-work-strip[data-work-id=3356150]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356150,"title":"DNA sequence analysis of\u003c i\u003e rdxA\u003c/i\u003e and\u003c i\u003e frxA\u003c/i\u003e from paired metronidazole-sensitive and-resistant\u003c i\u003e Helicobacter pylori\u003c/i\u003e isolates obtained from patients …","translated_title":"","metadata":{"publisher":"Elsevier","grobid_abstract":"Genomic variations of rdxA and frxA genes in eight pairs of metronidazole (MTZ)-sensitive and -resistant isolates of Helicobacter pylori were investigated. The paired strains from each single biopsy had identical lspA-glmM restriction fragment length polymorphism profiles, and the differences in MTZ susceptibility were mostly accounted for by mutations in the rdxA gene. Truncation of RdxA is associated with a minimum inhibitory concentration of 64-128 mg/L. Early truncation of FrxA was observed both in susceptible and resistant isolates of seven paired strains. Inactivation of frxA might play a significant role only in one low-level MTZ-resistant isolate where a missense mutation was found in the rdxA gene.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"International journal of …","grobid_abstract_attachment_id":50317935},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356150/DNA_sequence_analysis_of_i_rdxA_i_and_i_frxA_i_from_paired_metronidazole_sensitive_and_resistant_i_Helicobacter_pylori_i_isolates_obtained_from_patients_","translated_internal_url":"","created_at":"2013-04-22T04:04:58.977-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317935,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317935/thumbnails/1.jpg","file_name":"j.ijantimicag.2005.09.01920161115-18925-163sgmg.pdf","download_url":"https://www.academia.edu/attachments/50317935/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"DNA_sequence_analysis_of_i_rdxA_i_and_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317935/j.ijantimicag.2005.09.01920161115-18925-163sgmg-libre.pdf?1479198389=\u0026response-content-disposition=attachment%3B+filename%3DDNA_sequence_analysis_of_i_rdxA_i_and_i.pdf\u0026Expires=1733037245\u0026Signature=ZHSqtqZjikBSL51ftbMkWPURa5ERjsAYkCob62e6pVmHwilnSga~B7~-HVMCPK-6KGtyGUe7htf97RrUR4Ot8sx4nNqjPAaw32DdY9nu7vaRSVz7~Oajgy1s74wTbCUImBrTHnrU9wEYJSQH3JgtlSFGjx4rxA0f9EntQuho~SPR0iUeoB0wqOpWMfbH3NcWsfV~hlvDrvCRTdplPohV3x0nS~pMo0Sf113eiKXReLmRCaVcv7zqvc4Bgrn6~mulqaOHRiALOknxDwx2QBGV2keDZFOxL53xxnpvqQxpPH4r1lZ5avJ-ygeGXWRi8XCKLs9LBhMDOh80ajxGMljHSw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"DNA_sequence_analysis_of_i_rdxA_i_and_i_frxA_i_from_paired_metronidazole_sensitive_and_resistant_i_Helicobacter_pylori_i_isolates_obtained_from_patients_","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":50317935,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317935/thumbnails/1.jpg","file_name":"j.ijantimicag.2005.09.01920161115-18925-163sgmg.pdf","download_url":"https://www.academia.edu/attachments/50317935/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"DNA_sequence_analysis_of_i_rdxA_i_and_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317935/j.ijantimicag.2005.09.01920161115-18925-163sgmg-libre.pdf?1479198389=\u0026response-content-disposition=attachment%3B+filename%3DDNA_sequence_analysis_of_i_rdxA_i_and_i.pdf\u0026Expires=1733037245\u0026Signature=ZHSqtqZjikBSL51ftbMkWPURa5ERjsAYkCob62e6pVmHwilnSga~B7~-HVMCPK-6KGtyGUe7htf97RrUR4Ot8sx4nNqjPAaw32DdY9nu7vaRSVz7~Oajgy1s74wTbCUImBrTHnrU9wEYJSQH3JgtlSFGjx4rxA0f9EntQuho~SPR0iUeoB0wqOpWMfbH3NcWsfV~hlvDrvCRTdplPohV3x0nS~pMo0Sf113eiKXReLmRCaVcv7zqvc4Bgrn6~mulqaOHRiALOknxDwx2QBGV2keDZFOxL53xxnpvqQxpPH4r1lZ5avJ-ygeGXWRi8XCKLs9LBhMDOh80ajxGMljHSw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":21460,"name":"Helicobacter pylori","url":"https://www.academia.edu/Documents/in/Helicobacter_pylori"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":509981,"name":"Antimicrobial agents","url":"https://www.academia.edu/Documents/in/Antimicrobial_agents"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":1303572,"name":"Metronidazole","url":"https://www.academia.edu/Documents/in/Metronidazole"},{"id":1692059,"name":"Minimum inhibitory concentration","url":"https://www.academia.edu/Documents/in/Minimum_inhibitory_concentration"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="483507" id="papers"><div class="js-work-strip profile--work_container" data-work-id="3356172"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356172/S_Adenosylmethionine_in_cell_growth_apoptosis_and_liver_cancer"><img alt="Research paper thumbnail of S‐Adenosylmethionine in cell growth, apoptosis and liver cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/50317929/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356172/S_Adenosylmethionine_in_cell_growth_apoptosis_and_liver_cancer">S‐Adenosylmethionine in cell growth, apoptosis and liver cancer</a></div><div class="wp-workCard_item"><span>Journal of gastroenterology and hepatology</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="340cfbb876c1f9efb97044a33388fae3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317929,"asset_id":3356172,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317929/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356172"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356172"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356172; 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In mammals, two genes (MAT1A and MAT2A), encode for two homologous MAT catalytic subunits, while a third gene MAT2β, encodes for the β-subunit that regulates MAT2A-encoded isoenzyme. Normal liver expresses MAT1A, whereas extrahepatic tissues express MAT2A. MAT2A and MAT2β are induced in human hepatocellular carcinoma (HCC), which facilitate cancer cell growth. Patients with cirrhosis of various etiologies, including alcohol, have decreased hepatic MAT activity and SAMe biosynthesis. Consequences of hepatic SAMe deficiency as illustrated by the Mat1a knock-out mouse model include increased susceptibility to steatosis and oxidative liver injury, spontaneous development of steatohepatitis and HCC. Predisposition to HCC can be partly explained by the effect of SAMe on growth. Thus, SAMe inhibits the mitogenic effect of growth factors such as hepatocyte growth factor and, following partial hepatectomy, a fall in SAMe level is required for the liver to regenerate. During liver regeneration, the fall in hepatic SAMe is transient. If the fall were to persist, it would favor a proliferative phenotype and, ultimately, development of HCC. Not only does SAMe control liver growth, it also regulates apoptosis. Interestingly, SAMe is anti-apoptotic in normal hepatocytes but pro-apoptotic in liver cancer cells. In liver cancer cells but not in normal human hepatocytes, SAMe can selectively induce Bcl-x S , an alternatively spliced isoform of Bcl-x L that promotes apoptosis. This should make SAMe an attractive agent for both chemoprevention and treatment of HCC.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Journal of gastroenterology and hepatology","grobid_abstract_attachment_id":50317929},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356172/S_Adenosylmethionine_in_cell_growth_apoptosis_and_liver_cancer","translated_internal_url":"","created_at":"2013-04-22T04:05:20.243-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317929,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317929/thumbnails/1.jpg","file_name":"S-Adenosylmethionine_in_cell_growth_apop20161115-18932-19lwy8o.pdf","download_url":"https://www.academia.edu/attachments/50317929/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"S_Adenosylmethionine_in_cell_growth_apop.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317929/S-Adenosylmethionine_in_cell_growth_apop20161115-18932-19lwy8o-libre.pdf?1479198395=\u0026response-content-disposition=attachment%3B+filename%3DS_Adenosylmethionine_in_cell_growth_apop.pdf\u0026Expires=1733037244\u0026Signature=Rtun7rGs09yTlAG8iImnZLvUY-v3SiucPYBOqrvvHnBtz5047ap5eh7vCcAPV0zcFhTxrrgpJVjCHh-KJ7KHzOwXkClwdfew1~EmM~OiPimpEXhPYaEb369-vijTjg1wca278kQ1onCNQnrGa3af20FoCMT-zsfTChxhjCEdxD1v6ntQjXwX-N62L8G2-tvI~bdQo--UhHXFQww2BGfPQKO-Epvx5gyRZaU2HayprEPnqpuoO1hz4mWo6-FDMe8~5cqPtCORHdJZteNLjHJnsTIp1TAhlmUh4el~dW-E5Hv6JRKeRGKK~oQUxNGIJhcmJAcCAoU1bCHcAu0Qt~Oohw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"S_Adenosylmethionine_in_cell_growth_apoptosis_and_liver_cancer","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":50317929,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317929/thumbnails/1.jpg","file_name":"S-Adenosylmethionine_in_cell_growth_apop20161115-18932-19lwy8o.pdf","download_url":"https://www.academia.edu/attachments/50317929/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"S_Adenosylmethionine_in_cell_growth_apop.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317929/S-Adenosylmethionine_in_cell_growth_apop20161115-18932-19lwy8o-libre.pdf?1479198395=\u0026response-content-disposition=attachment%3B+filename%3DS_Adenosylmethionine_in_cell_growth_apop.pdf\u0026Expires=1733037244\u0026Signature=Rtun7rGs09yTlAG8iImnZLvUY-v3SiucPYBOqrvvHnBtz5047ap5eh7vCcAPV0zcFhTxrrgpJVjCHh-KJ7KHzOwXkClwdfew1~EmM~OiPimpEXhPYaEb369-vijTjg1wca278kQ1onCNQnrGa3af20FoCMT-zsfTChxhjCEdxD1v6ntQjXwX-N62L8G2-tvI~bdQo--UhHXFQww2BGfPQKO-Epvx5gyRZaU2HayprEPnqpuoO1hz4mWo6-FDMe8~5cqPtCORHdJZteNLjHJnsTIp1TAhlmUh4el~dW-E5Hv6JRKeRGKK~oQUxNGIJhcmJAcCAoU1bCHcAu0Qt~Oohw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":111972,"name":"Hepatocellular Carcinoma","url":"https://www.academia.edu/Documents/in/Hepatocellular_Carcinoma"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":260020,"name":"GASTROENTEROLOGY AND HEPATOLOGY.","url":"https://www.academia.edu/Documents/in/GASTROENTEROLOGY_AND_HEPATOLOGY"},{"id":432593,"name":"Hepatocytes","url":"https://www.academia.edu/Documents/in/Hepatocytes"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":923704,"name":"S-Adenosylmethionine","url":"https://www.academia.edu/Documents/in/S-Adenosylmethionine"},{"id":1954130,"name":"Cell Growth","url":"https://www.academia.edu/Documents/in/Cell_Growth"}],"urls":[{"id":1048275,"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408691/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356170"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356170/Abonos_org%C3%A1nicos_y_su_efecto_en_propiedades_f%C3%ADsicas_y_qu%C3%ADmicas_del_suelo_y_rendimiento_en_ma%C3%ADz"><img alt="Research paper thumbnail of Abonos orgánicos y su efecto en propiedades físicas y químicas del suelo y rendimiento en maíz" class="work-thumbnail" src="https://attachments.academia-assets.com/31165830/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356170/Abonos_org%C3%A1nicos_y_su_efecto_en_propiedades_f%C3%ADsicas_y_qu%C3%ADmicas_del_suelo_y_rendimiento_en_ma%C3%ADz">Abonos orgánicos y su efecto en propiedades físicas y químicas del suelo y rendimiento en maíz</a></div><div class="wp-workCard_item"><span>Terra</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a398554a91bd8c853bc177a905fe43d7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":31165830,"asset_id":3356170,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/31165830/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356170"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356170"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356170; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356170]").text(description); $(".js-view-count[data-work-id=3356170]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356170; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356170']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356170, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Se desarrolló un trabajo con los siguientes objetivos: a) Evaluar el efecto de los abonos orgánicos sobre propiedades físicas y químicas del suelo y b) Seleccionar el abono orgánico que produzca la mejor respuesta sobre rendimiento de grano. Se evaluaron cuatro tratamientos de abonos orgánicos a dosis de 20, 30 y 40 t ha -1 para bovino, caprino y composta, y 4, 8 y 12 t ha -1 para gallinaza, y un testigo con fertilización inorgánica (120-40-00 de N-P-K). Se utilizó el maíz genotipo San Lorenzo, establecido en un diseño bloques al azar con arreglo factorial A*B con tres repeticiones. Las variables que se evaluaron fueron: contenido de humedad, pH, materia orgánica, N, P y rendimiento de grano. Los resultados indican cambios en las características químicas del suelo (materia orgánica, N y P) antes y después de la siembra. En el caso de características físicas, no existió diferencia significativa. El rendimiento de grano con el tratamiento de fertilización inorgánica 120-40-00 de N-P-K fue el mejor (6.05 t ha -1 ); el abono orgánico de composta (5.66 t ha -1 ) mostró similares resultados. Los abonos orgánicos, principalmente composta con dosis de 20 a 30 t ha -1 , son una alternativa para sustituir a la fertilización inorgánica.","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Terra","grobid_abstract_attachment_id":31165830},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356170/Abonos_org%C3%A1nicos_y_su_efecto_en_propiedades_f%C3%ADsicas_y_qu%C3%ADmicas_del_suelo_y_rendimiento_en_ma%C3%ADz","translated_internal_url":"","created_at":"2013-04-22T04:05:19.555-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":31165830,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/31165830/thumbnails/1.jpg","file_name":"estudiodecasomz.pdf","download_url":"https://www.academia.edu/attachments/31165830/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Abonos_organicos_y_su_efecto_en_propieda.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/31165830/estudiodecasomz-libre.pdf?1392244425=\u0026response-content-disposition=attachment%3B+filename%3DAbonos_organicos_y_su_efecto_en_propieda.pdf\u0026Expires=1733037244\u0026Signature=NmmQNWvDh96CfYHFnHaC6rspTS6v2ZlDXkrQ-RIf1qjtQHIOSy7gKSfuU5jl4Ahup1csDj1kmVLPj5GQsxzYt6NZ3BXAwZd7FaWHpXazMVaGtMn-Tc2KDqpQb6277DPUKb2K36Lnh7UNQ56MKZKB44RQCJB4neViHBf9xudufeKBxU-WxfApDCENr5UzN7~pA4s29y~WiXy1AQ6R5-m~gR6wJSJQGualQh5cAv0VTbTQnFL-y0N4iyFZRepcC9HL5fKkInhCVz0fhRHkfZIUqph3JlNbH2rzdTzWqnqmupBVN600As7lpM65P~QfBkfJWu8ghd~JDCzXpatfiyKP0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Abonos_orgánicos_y_su_efecto_en_propiedades_físicas_y_químicas_del_suelo_y_rendimiento_en_maíz","translated_slug":"","page_count":7,"language":"es","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":31165830,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/31165830/thumbnails/1.jpg","file_name":"estudiodecasomz.pdf","download_url":"https://www.academia.edu/attachments/31165830/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Abonos_organicos_y_su_efecto_en_propieda.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/31165830/estudiodecasomz-libre.pdf?1392244425=\u0026response-content-disposition=attachment%3B+filename%3DAbonos_organicos_y_su_efecto_en_propieda.pdf\u0026Expires=1733037244\u0026Signature=NmmQNWvDh96CfYHFnHaC6rspTS6v2ZlDXkrQ-RIf1qjtQHIOSy7gKSfuU5jl4Ahup1csDj1kmVLPj5GQsxzYt6NZ3BXAwZd7FaWHpXazMVaGtMn-Tc2KDqpQb6277DPUKb2K36Lnh7UNQ56MKZKB44RQCJB4neViHBf9xudufeKBxU-WxfApDCENr5UzN7~pA4s29y~WiXy1AQ6R5-m~gR6wJSJQGualQh5cAv0VTbTQnFL-y0N4iyFZRepcC9HL5fKkInhCVz0fhRHkfZIUqph3JlNbH2rzdTzWqnqmupBVN600As7lpM65P~QfBkfJWu8ghd~JDCzXpatfiyKP0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":494184,"name":"Terra","url":"https://www.academia.edu/Documents/in/Terra"}],"urls":[{"id":1048274,"url":"http://ceuta.org.uy/files/estudiodecasomz.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356169"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356169/Complications_of_laser_dermatologic_surgery"><img alt="Research paper thumbnail of Complications of laser dermatologic surgery" class="work-thumbnail" src="https://attachments.academia-assets.com/50317926/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356169/Complications_of_laser_dermatologic_surgery">Complications of laser dermatologic surgery</a></div><div class="wp-workCard_item"><span>Lasers in surgery …</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="15c73260b671a19b1c12b10dee71633e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317926,"asset_id":3356169,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317926/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356169"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356169"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356169; 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Safety remains a primary concern and the timely communication of complications and their management is vital to insure that treatments be as safe as possible. The purpose of this report on the Proceedings of the First International Laser Surgery Morbidity Meeting is to provide laser experts the opportunity to present and discuss complications that their patients have experienced and how they were successfully managed. Methods: Laser experts were invited to present complications of laser, light, and radiofrequency treatments that their patients have experienced and to discuss the potential mechanisms leading to the complications their management and final outcomes. Results: Nineteen unique cases are presented and the clinical management of each case discussed. Eighteen sets of pre-and post-operative photos are presented. Conclusion: This report shows that even experts, with extensive experience using light-based therapies, can and do have patients who develop complications. 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356168]").text(description); $(".js-view-count[data-work-id=3356168]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356168; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356168']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356168, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356167/Spin_crossover_bistability_in_three_mutually_perpendicular_interpenetrated_4_4_nets">Spin crossover bistability in three mutually perpendicular interpenetrated (4, 4) nets</a></div><div class="wp-workCard_item"><span>Inorganic …</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Sylvie Létard, Xavier Solans, Nieves Menéndez, Antoine Goujon, François Varret, and José Anto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Sylvie Létard, Xavier Solans, Nieves Menéndez, Antoine Goujon, François Varret, and José Antonio Real*. ... Chandrasekar Rajadurai, Frank Schramm, Susan Brink, Olaf Fuhr, Mohamed Ghafari, Robert Kruk, and Mario Ruben. Inorganic Chemistry 2006 45 (25), 10019-10021. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356167"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356167"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356167; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356167]").text(description); $(".js-view-count[data-work-id=3356167]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356167; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356167']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356167, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=3356167]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356167,"title":"Spin crossover bistability in three mutually perpendicular interpenetrated (4, 4) nets","translated_title":"","metadata":{"abstract":"... Sylvie Létard, Xavier Solans, Nieves Menéndez, Antoine Goujon, François Varret, and José Antonio Real*. ... Chandrasekar Rajadurai, Frank Schramm, Susan Brink, Olaf Fuhr, Mohamed Ghafari, Robert Kruk, and Mario Ruben. Inorganic Chemistry 2006 45 (25), 10019-10021. ...","publisher":"ACS Publications","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Inorganic …"},"translated_abstract":"... Sylvie Létard, Xavier Solans, Nieves Menéndez, Antoine Goujon, François Varret, and José Antonio Real*. ... Chandrasekar Rajadurai, Frank Schramm, Susan Brink, Olaf Fuhr, Mohamed Ghafari, Robert Kruk, and Mario Ruben. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356166"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356166/New_antitrichomonal_drug_like_chemicals_selected_by_bond_edge_based_TOMOCOMD_CARDD_descriptors"><img alt="Research paper thumbnail of New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors" class="work-thumbnail" src="https://attachments.academia-assets.com/50317924/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356166/New_antitrichomonal_drug_like_chemicals_selected_by_bond_edge_based_TOMOCOMD_CARDD_descriptors">New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors</a></div><div class="wp-workCard_item"><span>Journal of …</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="91cfaa984f610202b6821aad7ecc8829" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317924,"asset_id":3356166,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317924/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356166"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356166"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356166; 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The obtained LDA-based quantitative structure-activity relationships (QSAR) models, using nonstochastic and stochastic indices, were able to classify correctly 87.91% (87.50%) and 89.01% (84.38%) of the chemicals in training (test) sets, respectively. They showed large Matthews correlation coefficients of 0.75 (0.71) and 0.78 (0.65) for the training (test) sets, correspondingly. Later, both models were applied to the virtual screening of 21 chemicals to find new lead antitrichomonal agents. Predictions agreed with experimental results to a great extent because a correct classification for both models of 95.24% (20 of 21) of the chemicals was obtained. Of the 21 compounds that were screened and synthesized, 2 molecules (chemicals G-1, UC-245) showed high to moderate cytocidal activity at the concentration of 10 mg/ml, another 2 compounds (G-0 and CRIS-148) showed high cytocidal activity only at the concentration of 100 mg/ml, and the remaining chemicals (from CRIS-105 to were inactive at these assayed concentrations. Finally, the best candidate, G-1 (cytocidal activity of 100% at 10 mg/ml) was in vivo assayed in ovariectomized Wistar rats achieving promising results as a trichomonacidal drug-like compound. (Journal of Biomolecular Screening 2008:785-794).","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Journal of …","grobid_abstract_attachment_id":50317924},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356166/New_antitrichomonal_drug_like_chemicals_selected_by_bond_edge_based_TOMOCOMD_CARDD_descriptors","translated_internal_url":"","created_at":"2013-04-22T04:05:16.144-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317924,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317924/thumbnails/1.jpg","file_name":"785.full.pdf","download_url":"https://www.academia.edu/attachments/50317924/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"New_antitrichomonal_drug_like_chemicals.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317924/785.full-libre.pdf?1479198396=\u0026response-content-disposition=attachment%3B+filename%3DNew_antitrichomonal_drug_like_chemicals.pdf\u0026Expires=1733037244\u0026Signature=XzwJ-43V-V1XGy9mT3362RaUumBhrYgKAQjbZglBI9~Vft2rXVOrOHRQ5qQbaeu3lSy6YmwJZdAj3kE7lOhQeJcho6bJewXUf4Z82OYqHeoCcMYOpqxm7PLTzgoBjkMDBy2UaqZKp0DX0i7yxeSZsxAsvD8aTxSnsF5aYU5cMDzb89N5nUWfxu0UvjZ-A4Ab2wudr1DC5xXvMnMT19bsBOqmABNCCpPTlTOc4ywuVmlISn76PMRVOH7XXNPYHWBs1JepYYOhxLx482N4GXKKxsAcfyrID~38PlEID9KVnn4jzT3Rqois1JgydgBQ4XTnaCgJSLDOksfTpj6vodJlWg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"New_antitrichomonal_drug_like_chemicals_selected_by_bond_edge_based_TOMOCOMD_CARDD_descriptors","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":50317924,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317924/thumbnails/1.jpg","file_name":"785.full.pdf","download_url":"https://www.academia.edu/attachments/50317924/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"New_antitrichomonal_drug_like_chemicals.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317924/785.full-libre.pdf?1479198396=\u0026response-content-disposition=attachment%3B+filename%3DNew_antitrichomonal_drug_like_chemicals.pdf\u0026Expires=1733037244\u0026Signature=XzwJ-43V-V1XGy9mT3362RaUumBhrYgKAQjbZglBI9~Vft2rXVOrOHRQ5qQbaeu3lSy6YmwJZdAj3kE7lOhQeJcho6bJewXUf4Z82OYqHeoCcMYOpqxm7PLTzgoBjkMDBy2UaqZKp0DX0i7yxeSZsxAsvD8aTxSnsF5aYU5cMDzb89N5nUWfxu0UvjZ-A4Ab2wudr1DC5xXvMnMT19bsBOqmABNCCpPTlTOc4ywuVmlISn76PMRVOH7XXNPYHWBs1JepYYOhxLx482N4GXKKxsAcfyrID~38PlEID9KVnn4jzT3Rqois1JgydgBQ4XTnaCgJSLDOksfTpj6vodJlWg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6160,"name":"Computer Aided Design","url":"https://www.academia.edu/Documents/in/Computer_Aided_Design"},{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software"},{"id":63360,"name":"Discriminant Analysis","url":"https://www.academia.edu/Documents/in/Discriminant_Analysis"},{"id":70037,"name":"Virtual screening","url":"https://www.academia.edu/Documents/in/Virtual_screening"},{"id":131572,"name":"Trichomonas vaginalis","url":"https://www.academia.edu/Documents/in/Trichomonas_vaginalis"},{"id":154817,"name":"Lead Generation","url":"https://www.academia.edu/Documents/in/Lead_Generation"},{"id":157521,"name":"Quantitative Structure Activity Relationship","url":"https://www.academia.edu/Documents/in/Quantitative_Structure_Activity_Relationship"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure"},{"id":2053987,"name":"Ovariectomy","url":"https://www.academia.edu/Documents/in/Ovariectomy"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356165"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356165/Reaction_of_rat_connective_tissue_to_implanted_dentin_tubes_filled_with_a_white_mineral_trioxide_aggregate"><img alt="Research paper thumbnail of Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate" class="work-thumbnail" src="https://attachments.academia-assets.com/50317922/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356165/Reaction_of_rat_connective_tissue_to_implanted_dentin_tubes_filled_with_a_white_mineral_trioxide_aggregate">Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate</a></div><div class="wp-workCard_item"><span>Brazilian Dental …</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="10576b8aad84d48b4ecc27e65b8d855f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317922,"asset_id":3356165,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317922/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356165"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356165"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356165; 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The tubes were implanted into rat subcutaneous tissue and the animals were sacrificed after 7 and 30 days. The undecalcified pieces were prepared for histological analysis with polarized light and von Kossa technique for mineralized tissues. Granulations birefringent to polarized light and an irregular structure like a bridge were observed next to the material; both were von Kossa positive. Also, in the dentin wall tubules a layer of birefringent granulations was observed. 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class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356164/Antiprotozoal_activity_of_diamine_derivatives">Antiprotozoal activity of diamine derivatives</a></div><div class="wp-workCard_item"><span>Biomedicine & Pharmacotherapy</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trich...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20μg/mL. N-hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T. vaginalis with MIC of 2.5μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti-G. lamblia activity than MTZ.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356164"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356164"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356164; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356164]").text(description); $(".js-view-count[data-work-id=3356164]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356164; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356164']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356164, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=3356164]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356164,"title":"Antiprotozoal activity of diamine derivatives","translated_title":"","metadata":{"abstract":"Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356162/Investigation_of_lysosomal_storage_diseases_in_nonimmune_hydrops_fetalis">Investigation of lysosomal storage diseases in nonimmune hydrops fetalis</a></div><div class="wp-workCard_item"><span>Prenatal …</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f06761282d7613c84caaecdc9c3bceab" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317931,"asset_id":3356162,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317931/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356161/Comparative_study_of_MTA_and_other_materials_in_retrofilling_of_pulpless_dogs_teeth"><img alt="Research paper thumbnail of Comparative study of MTA and other materials in retrofilling of pulpless dogs' teeth" class="work-thumbnail" src="https://attachments.academia-assets.com/50317925/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356161/Comparative_study_of_MTA_and_other_materials_in_retrofilling_of_pulpless_dogs_teeth">Comparative study of MTA and other materials in retrofilling of pulpless dogs' teeth</a></div><div class="wp-workCard_item"><span>Brazilian Dental …</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This in vivo study compared the effect of mineral trioxide aggregate (MTA), IRM, Super EBA and ZO...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This in vivo study compared the effect of mineral trioxide aggregate (MTA), IRM, Super EBA and ZOE in a puttylike consistency, used as retrofilling materials, in the healing process of periapical tissue of pulpless dogs' teeth submitted to a conventional retrofilling technique. Twenty-four premolars obtained from three dogs were used. At the first intervention, the animals were anesthetized, coronal access was obtained and pulpectomy was done. Root canals were kept open to the oral environment for 180 days to induce the formation of apical lesions. After surgical removal of the lesions with curettes, 2 mm of the apical root was cut out perpendicular to the long axis of the teeth, and root-end cavities were shaped with a low-speed round bur. The bone cavities were irrigated and dried, and the root-end cavities were filled with MTA, IRM, Super EBA and ZOE in a puttylike consistency. The bone cavities were passively filled with blood and flaps were sutured. The coronal access openings were cleaned and double-sealed with ZOE and amalgam. After 180 days, the animals were killed by anesthetic overdose, maxilla and mandible were removed and the pieces were processed for histomorphologic analysis. Data were evaluated blindly on the basis of several histopathologic events and the scores obtained were analyzed statistically using the Kruskal Wallis test. No significant differences were observed among MTA, Super EBA and IRM (p>0.05). However, ZOE had a significantly more negative influence on the apical healing (p<0.05). In conclusion, MTA, Super EBA and IRM had similar histopathologic effects among each other and better performance than ZOE used in a puttylike consistency. Furthermore, only MTA stimulated hard tissue deposition in direct contact with the retrofilling material, even when it was inserted under critical conditions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9aa03f006c50e267d9b59ea7d9111808" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317925,"asset_id":3356161,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317925/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356161; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356161]").text(description); $(".js-view-count[data-work-id=3356161]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356161; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356161']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356161, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9aa03f006c50e267d9b59ea7d9111808" } } $('.js-work-strip[data-work-id=3356161]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356161,"title":"Comparative study of MTA and other materials in retrofilling of pulpless dogs' teeth","translated_title":"","metadata":{"abstract":"This in vivo study compared the effect of mineral trioxide aggregate (MTA), IRM, Super EBA and ZOE in a puttylike consistency, used as retrofilling materials, in the healing process of periapical tissue of pulpless dogs' teeth submitted to a conventional retrofilling technique. Twenty-four premolars obtained from three dogs were used. At the first intervention, the animals were anesthetized, coronal access was obtained and pulpectomy was done. Root canals were kept open to the oral environment for 180 days to induce the formation of apical lesions. After surgical removal of the lesions with curettes, 2 mm of the apical root was cut out perpendicular to the long axis of the teeth, and root-end cavities were shaped with a low-speed round bur. The bone cavities were irrigated and dried, and the root-end cavities were filled with MTA, IRM, Super EBA and ZOE in a puttylike consistency. The bone cavities were passively filled with blood and flaps were sutured. The coronal access openings were cleaned and double-sealed with ZOE and amalgam. After 180 days, the animals were killed by anesthetic overdose, maxilla and mandible were removed and the pieces were processed for histomorphologic analysis. 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After surgical removal of the lesions with curettes, 2 mm of the apical root was cut out perpendicular to the long axis of the teeth, and root-end cavities were shaped with a low-speed round bur. The bone cavities were irrigated and dried, and the root-end cavities were filled with MTA, IRM, Super EBA and ZOE in a puttylike consistency. The bone cavities were passively filled with blood and flaps were sutured. The coronal access openings were cleaned and double-sealed with ZOE and amalgam. After 180 days, the animals were killed by anesthetic overdose, maxilla and mandible were removed and the pieces were processed for histomorphologic analysis. Data were evaluated blindly on the basis of several histopathologic events and the scores obtained were analyzed statistically using the Kruskal Wallis test. No significant differences were observed among MTA, Super EBA and IRM (p\u003e0.05). However, ZOE had a significantly more negative influence on the apical healing (p\u003c0.05). 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hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356159/Removal_of_an_emerging_pharmaceutical_compound_by_adsorption_in_fixed_bed_column"><img alt="Research paper thumbnail of Removal of an emerging pharmaceutical compound by adsorption in fixed bed column" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356159/Removal_of_an_emerging_pharmaceutical_compound_by_adsorption_in_fixed_bed_column">Removal of an emerging pharmaceutical compound by adsorption in fixed bed column</a></div><div class="wp-workCard_item"><span>Desalination and Water Treatment</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adsorption of atenolol on granular activated carbon in a fixed bed column was investigated. This ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adsorption of atenolol on granular activated carbon in a fixed bed column was investigated. This micropollutant was effectively adsorbed onto the activated carbon; therefore, the effect of some operation parameters on the performance of the breakthrough curve was studied. Some adsorption parameters, as the adsorption capacities at breakthrough and saturation time, the length of the mass transfer zone (mtz) and the fractional bed utilization were estimated. Four kinetic models, including Adams–Bohart, Wolborska, Thomas, and Yoon–Nelson model, were used to determine the adsorption parameters and to predict the breakthrough curves. Among all examined models, Thomas and Yoon–Nelson were found to be the most suitable for simulation of the breakthrough curve of atenolol uptake on granular activated carbon fixed bed column.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356159"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356159]").text(description); $(".js-view-count[data-work-id=3356159]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356159']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356159, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=3356159]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356159,"title":"Removal of an emerging pharmaceutical compound by adsorption in fixed bed column","translated_title":"","metadata":{"abstract":"Adsorption of atenolol on granular activated carbon in a fixed bed column was investigated. This micropollutant was effectively adsorbed onto the activated carbon; therefore, the effect of some operation parameters on the performance of the breakthrough curve was studied. Some adsorption parameters, as the adsorption capacities at breakthrough and saturation time, the length of the mass transfer zone (mtz) and the fractional bed utilization were estimated. Four kinetic models, including Adams–Bohart, Wolborska, Thomas, and Yoon–Nelson model, were used to determine the adsorption parameters and to predict the breakthrough curves. Among all examined models, Thomas and Yoon–Nelson were found to be the most suitable for simulation of the breakthrough curve of atenolol uptake on granular activated carbon fixed bed column.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Desalination and Water Treatment"},"translated_abstract":"Adsorption of atenolol on granular activated carbon in a fixed bed column was investigated. This micropollutant was effectively adsorbed onto the activated carbon; therefore, the effect of some operation parameters on the performance of the breakthrough curve was studied. Some adsorption parameters, as the adsorption capacities at breakthrough and saturation time, the length of the mass transfer zone (mtz) and the fractional bed utilization were estimated. Four kinetic models, including Adams–Bohart, Wolborska, Thomas, and Yoon–Nelson model, were used to determine the adsorption parameters and to predict the breakthrough curves. Among all examined models, Thomas and Yoon–Nelson were found to be the most suitable for simulation of the breakthrough curve of atenolol uptake on granular activated carbon fixed bed column.","internal_url":"https://www.academia.edu/3356159/Removal_of_an_emerging_pharmaceutical_compound_by_adsorption_in_fixed_bed_column","translated_internal_url":"","created_at":"2013-04-22T04:05:09.329-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Removal_of_an_emerging_pharmaceutical_compound_by_adsorption_in_fixed_bed_column","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[],"research_interests":[{"id":55,"name":"Environmental Engineering","url":"https://www.academia.edu/Documents/in/Environmental_Engineering"},{"id":72,"name":"Chemical Engineering","url":"https://www.academia.edu/Documents/in/Chemical_Engineering"},{"id":73,"name":"Civil Engineering","url":"https://www.academia.edu/Documents/in/Civil_Engineering"},{"id":2024,"name":"Mass Transfer","url":"https://www.academia.edu/Documents/in/Mass_Transfer"},{"id":39752,"name":"Adsorption","url":"https://www.academia.edu/Documents/in/Adsorption"},{"id":39753,"name":"Activated Carbon","url":"https://www.academia.edu/Documents/in/Activated_Carbon"},{"id":65757,"name":"Wastewater","url":"https://www.academia.edu/Documents/in/Wastewater"},{"id":291387,"name":"Mathematical Model","url":"https://www.academia.edu/Documents/in/Mathematical_Model"},{"id":835697,"name":"Lumping Kinetic Model","url":"https://www.academia.edu/Documents/in/Lumping_Kinetic_Model"},{"id":1137336,"name":"Granular Activated Carbon","url":"https://www.academia.edu/Documents/in/Granular_Activated_Carbon"},{"id":1434580,"name":"Breakthrough Curve","url":"https://www.academia.edu/Documents/in/Breakthrough_Curve"}],"urls":[{"id":1048267,"url":"http://dx.doi.org/10.1080/19443994.2012.692062"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356158/DNA_sequence_analysis_of_rdxA_and_frxA_from_paired_metronidazole_sensitive_and_resistant_Helicobacter_pylori_isolates_obtained_from_patients_with_heteroresistance"><img alt="Research paper thumbnail of DNA sequence analysis of rdxA and frxA from paired metronidazole-sensitive and -resistant Helicobacter pylori isolates obtained from patients with heteroresistance" class="work-thumbnail" src="https://attachments.academia-assets.com/50317932/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356158/DNA_sequence_analysis_of_rdxA_and_frxA_from_paired_metronidazole_sensitive_and_resistant_Helicobacter_pylori_isolates_obtained_from_patients_with_heteroresistance">DNA sequence analysis of rdxA and frxA from paired metronidazole-sensitive and -resistant Helicobacter pylori isolates obtained from patients with heteroresistance</a></div><div class="wp-workCard_item"><span>International Journal of Antimicrobial Agents</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8576dfe284153e3edc29851ace84effe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317932,"asset_id":3356158,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317932/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356158; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356158]").text(description); $(".js-view-count[data-work-id=3356158]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356158; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356158']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356158, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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The paired strains from each single biopsy had identical lspA-glmM restriction fragment length polymorphism profiles, and the differences in MTZ susceptibility were mostly accounted for by mutations in the rdxA gene. Truncation of RdxA is associated with a minimum inhibitory concentration of 64-128 mg/L. Early truncation of FrxA was observed both in susceptible and resistant isolates of seven paired strains. 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Pimonidazole hydrochloride (Hypoxyprobe) is an imaging agent that is bioreductively activated only under hypoxic conditions in mammalian tissue. We employed this probe to evaluate the oxygen tension in tuberculous granulomas in four animal models of disease: mouse, guinea pig, rabbit, and nonhuman primate. Following infusion of pimonidazole into animals with established infections, lung tissues from the guinea pig, rabbit, and nonhuman primate showed discrete areas of pimonidazole adduct formation surrounding necrotic and caseous regions of pulmonary granulomas by immunohistochemical staining. This labeling could be substantially reduced by housing the animal under an atmosphere of 95% O 2 . Direct measurement of tissue oxygen partial pressure by surgical insertion of a fiber optic oxygen probe into granulomas in the lungs of living infected rabbits demonstrated that even small (3-mm) pulmonary lesions were severely hypoxic (1.6 ؎ 0.7 mm Hg). Finally, metronidazole, which has potent bactericidal activity in vitro only under low-oxygen culture conditions, was highly effective at reducing total-lung bacterial burdens in infected rabbits. 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</script> <div class="js-work-strip profile--work_container" data-work-id="3356154"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356154/Bond_based_linear_indices_in_QSAR_computational_discovery_of_novel_anti_trichomonal_compounds"><img alt="Research paper thumbnail of Bond-based linear indices in QSAR: computational discovery of novel anti-trichomonal compounds" class="work-thumbnail" src="https://attachments.academia-assets.com/50317933/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356154/Bond_based_linear_indices_in_QSAR_computational_discovery_of_novel_anti_trichomonal_compounds">Bond-based linear indices in QSAR: computational discovery of novel anti-trichomonal compounds</a></div><div class="wp-workCard_item"><span>Journal of Computer-aided Molecular Design</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Trichomonas vaginalis (Tv) is the causative agent of the most common, non-viral, sexually transmi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Trichomonas vaginalis (Tv) is the causative agent of the most common, non-viral, sexually transmitted disease in women and men worldwide. Since 1959, metronidazole (MTZ) has been the drug of choice in the systemic treatment of trichomoniasis. However, resistance to MTZ in some patients and the great cost associated with the development of new trichomonacidals make necessary the development of computational methods that shorten the drug discovery pipeline. Toward this end, bond-based linear indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis were used to discover novel trichomonacidal chemicals. The obtained models, using non-stochastic and stochastic indices, are able to classify correctly 89.01% (87.50%) and 82.42% (84.38%) of the chemicals in the training (test) sets, respectively. These results validate the models for their use in the ligand-based virtual screening. In addition, they show large Matthews’ correlation coefficients (C) of 0.78 (0.71) and 0.65 (0.65) for the training (test) sets, correspondingly. The result of predictions on the 10% full-out cross-validation test also evidences the robustness of the obtained models. Later, both models are applied to the virtual screening of 12 compounds already proved against Tv. As a result, they correctly classify 10 out of 12 (83.33%) and 9 out of 12 (75.00%) of the chemicals, respectively; which is the most important criterion for validating the models. Besides, these classification functions are applied to a library of seven chemicals in order to find novel antitrichomonal agents. These compounds are synthesized and tested for in vitro activity against Tv. As a result, experimental observations approached to theoretical predictions, since it was obtained a correct classification of 85.71% (6 out of 7) of the chemicals. Moreover, out of the seven compounds that are screened, synthesized and biologically assayed, six compounds (VA7-34, VA7-35, VA7-37, VA7-38, VA7-68, VA7-70) show pronounced cytocidal activity at the concentration of 100 μg/ml at 24 h (48 h) within the range of 98.66%–100% (99.40%–100%), while only two molecules (chemicals VA7-37 and VA7-38) show high cytocidal activity at the concentration of 10 μg/ml at 24 h (48 h): 98.38% (94.23%) and 97.59% (98.10%), correspondingly. The LDA-assisted QSAR models presented here could significantly reduce the number of synthesized and tested compounds and could increase the chance of finding new chemical entities with anti-trichomonal activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="543a687de8d4aa8b2b443704b0778c9a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317933,"asset_id":3356154,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317933/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356154"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356154"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356154; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356154]").text(description); $(".js-view-count[data-work-id=3356154]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356154; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356154']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356154, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "543a687de8d4aa8b2b443704b0778c9a" } } $('.js-work-strip[data-work-id=3356154]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356154,"title":"Bond-based linear indices in QSAR: computational discovery of novel anti-trichomonal compounds","translated_title":"","metadata":{"abstract":"Trichomonas vaginalis (Tv) is the causative agent of the most common, non-viral, sexually transmitted disease in women and men worldwide. 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356153/Assessment_of_fetal_risk_associated_with_exposure_to_cancer_chemotherapy_during_pregnancy_a_multicenter_study"><img alt="Research paper thumbnail of Assessment of fetal risk associated with exposure to cancer chemotherapy during pregnancy: a multicenter study" class="work-thumbnail" src="https://attachments.academia-assets.com/50317936/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356153/Assessment_of_fetal_risk_associated_with_exposure_to_cancer_chemotherapy_during_pregnancy_a_multicenter_study">Assessment of fetal risk associated with exposure to cancer chemotherapy during pregnancy: a multicenter study</a></div><div class="wp-workCard_item"><span>Brazilian journal of …</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fdebe9cadf7df73b226d88d808033b58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317936,"asset_id":3356153,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317936/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356153"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span 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el: this, workJSON: {"id":3356153,"title":"Assessment of fetal risk associated with exposure to cancer chemotherapy during pregnancy: a multicenter study","translated_title":"","metadata":{"publisher":"SciELO Brasil","ai_title_tag":"Fetal Risks of Cancer Chemotherapy During Pregnancy","grobid_abstract":"The objective of the present study was to evaluate and quantify fetal risks involved in the administration of cancer chemotherapy during gestation, as well as to assess the long-term effects on the exposed children. In this retrospective, cohort study, we reviewed the records of women aged 15 to 45 years with a diagnosis of malignancy or benign tumors with malignant behavior at three reference services in the State of Rio Grande do Sul, Brazil, from 1990 to 1997. All patients with a diagnosis of pregnancy at any time during the course of the disease were selected, regardless of whether or not they received specific medication. Fetal outcomes of 14 pregnancies with chemotherapy exposure were compared to that of 15 control pregnancies in which these drugs were not used. Long-term follow-up of the exposed children was carried out. Fisher's exact test was used to compare the groups. Continuous variables were compared by the Wilcoxon-Mann-Whitney test. We found an increased rate of prematurity (6/8 vs 2/10; RR: 3.75; CI: 1.02-13.8; P = 0.03) in the exposed group. There was a trend to an increased fetal death rate (4/12 vs 0/10; P = 0.07) in the group exposed to chemotherapy. No malformations were detected in any child, which can be related to our small sample size as well as to the fact that most exposures occurred after the first trimester of pregnancy. Other larger, controlled studies are needed to establish the actual risk related to cancer chemotherapy during pregnancy.","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Brazilian journal of …","grobid_abstract_attachment_id":50317936},"translated_abstract":null,"internal_url":"https://www.academia.edu/3356153/Assessment_of_fetal_risk_associated_with_exposure_to_cancer_chemotherapy_during_pregnancy_a_multicenter_study","translated_internal_url":"","created_at":"2013-04-22T04:05:01.898-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":50317936,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317936/thumbnails/1.jpg","file_name":"Assessment_of_fetal_risk_associated_with20161115-18929-89z8wz.pdf","download_url":"https://www.academia.edu/attachments/50317936/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Assessment_of_fetal_risk_associated_with.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317936/Assessment_of_fetal_risk_associated_with20161115-18929-89z8wz-libre.pdf?1479198391=\u0026response-content-disposition=attachment%3B+filename%3DAssessment_of_fetal_risk_associated_with.pdf\u0026Expires=1733037245\u0026Signature=Jj-1oGcid9Rm-eQuzVMlEW~OXWFOnjPiXqEs2jmP9AxQo8aPUJiRs3kJCcxnJC3H7XMUpYrBZYwuSGEEBpgVILFvrwj9DnxMy2nfnMVvh2P~HiaA1qub~Vv1CHKlLgZ8UwOQEsmMKd4aa6EcqOPKLBf57fGryckvycuHsFWuD0ZppZK68-JMF901BJtEM9RAbtVCQ-IT6CME2HRjA~6LptoKKTLDK-e1wKz2SERil3qpQFCBwzNYyTXPErtXH2~ltdFgN-HDWoI6CTKRVKt79b~PYwzUnKDhSizUsuzYMhUhdVmQMXaajMUy8rN4GmPnBR18LqhDj1b9jOpeLlP7Iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Assessment_of_fetal_risk_associated_with_exposure_to_cancer_chemotherapy_during_pregnancy_a_multicenter_study","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz"},"attachments":[{"id":50317936,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/50317936/thumbnails/1.jpg","file_name":"Assessment_of_fetal_risk_associated_with20161115-18929-89z8wz.pdf","download_url":"https://www.academia.edu/attachments/50317936/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Assessment_of_fetal_risk_associated_with.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/50317936/Assessment_of_fetal_risk_associated_with20161115-18929-89z8wz-libre.pdf?1479198391=\u0026response-content-disposition=attachment%3B+filename%3DAssessment_of_fetal_risk_associated_with.pdf\u0026Expires=1733037245\u0026Signature=Jj-1oGcid9Rm-eQuzVMlEW~OXWFOnjPiXqEs2jmP9AxQo8aPUJiRs3kJCcxnJC3H7XMUpYrBZYwuSGEEBpgVILFvrwj9DnxMy2nfnMVvh2P~HiaA1qub~Vv1CHKlLgZ8UwOQEsmMKd4aa6EcqOPKLBf57fGryckvycuHsFWuD0ZppZK68-JMF901BJtEM9RAbtVCQ-IT6CME2HRjA~6LptoKKTLDK-e1wKz2SERil3qpQFCBwzNYyTXPErtXH2~ltdFgN-HDWoI6CTKRVKt79b~PYwzUnKDhSizUsuzYMhUhdVmQMXaajMUy8rN4GmPnBR18LqhDj1b9jOpeLlP7Iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":163353,"name":"Cancer Chemotherapy","url":"https://www.academia.edu/Documents/in/Cancer_Chemotherapy"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":483419,"name":"Brazilian","url":"https://www.academia.edu/Documents/in/Brazilian"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":797418,"name":"Gestational Age","url":"https://www.academia.edu/Documents/in/Gestational_Age"},{"id":1179060,"name":"Fetal death","url":"https://www.academia.edu/Documents/in/Fetal_death"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents"},{"id":1711123,"name":"Apgar Score","url":"https://www.academia.edu/Documents/in/Apgar_Score"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"}],"urls":[{"id":1048261,"url":"http://www.scielo.br/scielo.php?pid=S0100-879X2001001200007\u0026script=sci_arttext"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="3356152"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/3356152/Unsuspected_and_extensive_transmission_of_a_drug_susceptible_Mycobacterium_tuberculosis_strain"><img alt="Research paper thumbnail of Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain" class="work-thumbnail" src="https://attachments.academia-assets.com/50317930/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/3356152/Unsuspected_and_extensive_transmission_of_a_drug_susceptible_Mycobacterium_tuberculosis_strain">Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain</a></div><div class="wp-workCard_item"><span>BMC Pulmonary Medicine</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tube...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004. Methods The Mycobacterium tuberculosis drug-susceptible strain, named MTZ strain, was genetically characterized by IS6110-RFLP, Spoligotyping and by MIRU-VNTR typing and the genetic patterns obtained were compared with those included in international databases. The characteristics of the affected patients, in an attempt to understand why the MTZ strain was so highly transmitted among the population were also analyzed. Results The genetic profile of the MTZ strain was rare and not widely distributed in our area or elsewhere. The patients affected did not show any notable risk factor for TB. Conclusion The M. tuberculosis strain MTZ, might have particular transmissibility or virulence properties, and we believe that greater focus should be placed on stopping its widespread dissemination.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9f676a3fc71c111b8954c7fcf626df4d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50317930,"asset_id":3356152,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50317930/download_file?st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&st=MTczMzAzMzY0NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="3356152"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="3356152"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3356152; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3356152]").text(description); $(".js-view-count[data-work-id=3356152]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3356152; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='3356152']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 3356152, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9f676a3fc71c111b8954c7fcf626df4d" } } $('.js-work-strip[data-work-id=3356152]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":3356152,"title":"Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain","translated_title":"","metadata":{"abstract":"Background A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004. Methods The Mycobacterium tuberculosis drug-susceptible strain, named MTZ strain, was genetically characterized by IS6110-RFLP, Spoligotyping and by MIRU-VNTR typing and the genetic patterns obtained were compared with those included in international databases. The characteristics of the affected patients, in an attempt to understand why the MTZ strain was so highly transmitted among the population were also analyzed. Results The genetic profile of the MTZ strain was rare and not widely distributed in our area or elsewhere. The patients affected did not show any notable risk factor for TB. Conclusion The M. tuberculosis strain MTZ, might have particular transmissibility or virulence properties, and we believe that greater focus should be placed on stopping its widespread dissemination.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"BMC Pulmonary Medicine"},"translated_abstract":"Background A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004. Methods The Mycobacterium tuberculosis drug-susceptible strain, named MTZ strain, was genetically characterized by IS6110-RFLP, Spoligotyping and by MIRU-VNTR typing and the genetic patterns obtained were compared with those included in international databases. The characteristics of the affected patients, in an attempt to understand why the MTZ strain was so highly transmitted among the population were also analyzed. Results The genetic profile of the MTZ strain was rare and not widely distributed in our area or elsewhere. The patients affected did not show any notable risk factor for TB. 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DE LA RESISTENCIA AL DESGASTE DE APEROS MEDIANTE LA APLICACIÓN DEL RECARGUE SUPERFICIAL POR S...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... DE LA RESISTENCIA AL DESGASTE DE APEROS MEDIANTE LA APLICACIÓN DEL RECARGUE SUPERFICIAL POR SOLDADURA AUTOMÁTICA Elvis López B ... 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DE LA RESISTENCIA AL DESGASTE DE APEROS MEDIANTE LA APLICACIÓN DEL RECARGUE SUPERFICIAL POR SOLDADURA AUTOMÁTICA Elvis López B ... DE BIOMASA EN EL PROCESO DE SECADO AGROINDUSTRIAL Alain Ariel de la Rosa Andino /Luis Zamora ...","publication_date":{"day":null,"month":null,"year":2005,"errors":{}}},"translated_abstract":"... DE LA RESISTENCIA AL DESGASTE DE APEROS MEDIANTE LA APLICACIÓN DEL RECARGUE SUPERFICIAL POR SOLDADURA AUTOMÁTICA Elvis López B ... DE BIOMASA EN EL PROCESO DE SECADO AGROINDUSTRIAL Alain Ariel de la Rosa Andino /Luis Zamora ...","internal_url":"https://www.academia.edu/3356151/REPARACI%C3%93N_Y_TECNOLOG%C3%8DA_MEC%C3%81NICA_REPAIRING_AND_MECHANICAL_TECHNOLOGY","translated_internal_url":"","created_at":"2013-04-22T04:04:59.730-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3893510,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"REPARACIÓN_Y_TECNOLOGÍA_MECÁNICA_REPAIRING_AND_MECHANICAL_TECHNOLOGY","translated_slug":"","page_count":null,"language":"hr","content_type":"Work","owner":{"id":3893510,"first_name":"José","middle_initials":null,"last_name":"Mtz Mtz","page_name":"JoséMtzMtz","domain_name":"independent","created_at":"2013-04-22T04:02:29.949-07:00","display_name":"José Mtz Mtz","url":"https://independent.academia.edu/Jos%C3%A9MtzMtz","email":"MXdvbWZvMGo0Vm91bzl1cE5yWTVvOU9LSXg1ZlNaUDVHVHVOSjBnUmdybz0tLXlDRkRUTWdjVW5QdExDTjVEbUZleHc9PQ==--7551d9ea79adea770afdf5ad209ddd7d6a9edb0a"},"attachments":[],"research_interests":[],"urls":[{"id":1048259,"url":"http://redalyc.uaemex.mx/redalyc/pdf/932/93214206.pdf"}]}, dispatcherData: dispatcherData }); 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