Study reveals how cancer cells evade chemotherapy in low-glucose environments

<!DOCTYPE html> <html lang="en" itemscope itemtype="http://schema.org/NewsArticle"> <head> <link rel="preconnect" href="https://d2jx2rerrg6sh3.cloudfront.net" /> <link rel="preconnect" href="https://use.typekit.net" /> <link rel="preconnect" href="https://p.typekit.net" /> <link rel="preconnect" href="https://cdn-ukwest.onetrust.com" /> <link rel="preconnect" href="https://securepubads.g.doubleclick.net" /> <link rel="preconnect" href="https://pagead2.googlesyndication.com" /> <link rel="preconnect" href="https://www.googletagmanager.com" /> <link rel="preconnect" href="https://js.trendmd.com" /><meta charset="utf-8" /><meta http-equiv="X-UA-Compatible" content="IE=edge" /><meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1" /><title> Study reveals how cancer cells evade chemotherapy in low-glucose environments </title> <link rel="canonical" href="https://www.news-medical.net/news/20241126/Study-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx" /> <link itemprop="mainEntityOfPage" href="https://www.news-medical.net/news/20241126/Study-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx" /> <meta itemprop="description" content="Laboratory experiments with cancer cells reveal two ways in which tumors evade drugs designed to starve and kill them, a new study shows." /> <meta itemprop="datePublished" content="2024-11-26T07:41:00-05:00" /> <meta itemprop="dateModified" content="2024-11-26T07:41:00-05:00" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@NewsMedical" /> <meta name="twitter:title" content="Study reveals how cancer cells evade chemotherapy in low-glucose environments" /> <meta name="twitter:description" content="Laboratory experiments with cancer cells reveal two ways in which tumors evade drugs designed to starve and kill them, a new study shows." /> <meta name="twitter:image:src" content="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/7/Chemo_Vials-620x480.jpg" /> <meta property="og:title" content="Study reveals how cancer cells evade chemotherapy in low-glucose environments" /> <meta property="og:type" content="article" /> <meta property="og:image" content="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/7/Chemo_Vials-620x480.jpg" /> <meta property="og:url" content="https://www.news-medical.net/news/20241126/Study-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx" /> <meta property="og:description" content="Laboratory experiments with cancer cells reveal two ways in which tumors evade drugs designed to starve and kill them, a new study shows." /> <meta property="og:site_name" content="News-Medical" /> <meta property="article:published_time" content="2024-11-26T07:41:00-05:00" /> <meta property="article:modified_time" content="2024-11-26T07:41:00-05:00" /> <meta property="article:section" content="Medical News" /> <meta property="article:tag" content="Cancer" /> <meta property="article:tag" content="Chemotherapy" /> <meta property="fb:app_id" content="191532917554431" /> <meta name="referrer" content="unsafe-url" /><meta name="robots" content="max-snippet:-1, max-image-preview:large, max-video-preview:-1" /> <script type="text/javascript"> window.g_siteSection = 'medical'; window.g_hasSiteSections = true; window.g_cmpKind = 2; window.g_isIabTcfInUse = false; window.g_isIabGppInUse = false; window.bStrictCookies = undefined; window.g_cookiePolicyStatus = undefined; window.g_noAdSense = false; window.g_havePublishable = true; window.g_enableAnalytics = true; window.bRecordClientView = true; window.g_fetchPromotedItem = true; window.g_contentEmbedPromotedItemEligible = true; window.g_analyticsContentType = 'Medical e-News Item'; window.g_endemicId = '7947'; window.g_pageLoadStartOn = new Date(); window._azoStartScripts = []; window.$ = function(fn) { if (typeof fn === 'function') { _azoStartScripts.push(fn); } }; </script> <link rel="icon" href="/favicon-16x16.png" type="image/png" sizes="16x16" /><link rel="icon" href="/favicon-32x32.png" type="image/png" sizes="32x32" /><link rel="icon" href="/favicon-96x96.png" type="image/png" sizes="96x96" /><link type="application/rss+xml" rel="alternate" title="Study reveals how cancer cells evade chemotherapy in low-glucose environments (RSS)" href="/news/feed/20241126/Study-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx?format=ATOM" /><link type="application/rss+xml" rel="alternate" title="Study reveals how cancer cells evade chemotherapy in low-glucose environments (ATOM)" href="/news/feed/20241126/Study-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx?format=ATOM" /><link rel="start" title="The Medical News" href="/" /><link type="application/rss+xml" rel="alternate" title="The Medical News (RSS)" href="https://www.news-medical.net/syndication.axd?format=rss" /><link type="application/atom+xml" rel="alternate" title="The Medical News (ATOM)" href="https://www.news-medical.net/syndication.axd?format=atom" /><meta http-equiv="content-type" content="text/html; charset=utf-8" /> <script> window.googleAnalyticsConfig = { 'gaCode': 'G-ZD4LNWPK1L', 'cookieDomain': 'news-medical.net' }; </script> <meta name="msvalidate.01" content="F19F0E4C53AF972CB554F2D6E02D6A95" /> <meta name="google-site-verification" content="O9YdVHPdPV4LcXLbPolbgWNCkqMfLIvjbuO_NGer4hk" /> <meta name="y_key" content="3022e9ac41851d3d" /> <link type="text/css" rel="stylesheet" href="https://d2jx2rerrg6sh3.cloudfront.net/bundles/css/desktop/base?v=H3NDnfqC0oBbirtGiLnNfyejH-8W282BNybDKVL_m5Q1" /> <link rel="stylesheet" href="https://use.typekit.net/iio3fgy.css" media="print" onload="this.media='all'; this.onload=null;"> <script type="text/javascript"> //<![CDATA[ window.sSiteRoot = '/'; window.isMobileWebsite = false; window.isMobileProSupplier = false; var g_azopgtg = ['5f4a4c','6a5b445b5f44584258','694744444f','694744444f0b785e4c4a59','684a45484e59','684e4747','684e47470b69424447444c52','684e47470b6f4e4a5f43','684e47470b664e5f4a494447425846','68434e46445f434e594a5b52','6f424a4c4544585f4248','6f656a','6f595e4c58','6e53434a5e585f424445','6c4e454e58','6c4e454e5f4248','6c475e4844584e','674a4944594a5f445952','664e4f424842454e','664e5f4a494447425846','66425f44484344454f59424a','655e48474e445f424f4e','655e48474e445f424f4e58','7b4a5f434447444c52','7b52594246424f42454e','794e584e4a594843','79656a','7f5e464459']; //]]> </script> <script type="text/javascript"> window.dataLayer = window.dataLayer || []; function gtag() { dataLayer.push(arguments); } gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'functionality_storage': 'denied', 'personalization_storage': 'denied', 'security_storage': 'granted', 'ad_user_data': 'denied', 'ad_personalization': 'denied' }); function initAnalytics() { var config = window.googleAnalyticsConfig; if (config) { var gtagConfig = { 'anonymize_ip': true, 'cookie_domain': config.cookieDomain }; if (window.g_analyticsContentType) { gtagConfig['content_group'] = window.g_analyticsContentType; } var a = document.createElement('script'); a.type = 'text/javascript'; a.async = true; a.src = 'https://www.googletagmanager.com/gtag/js?id=' + config.gaCode; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(a, s); window.dataLayer = window.dataLayer || []; window.gtag = function () { dataLayer.push(arguments); }; window.gtag('js', new Date()); window.gtag('config', config.gaCode, gtagConfig); } } function initPlausible() { if (!window.googleAnalyticsConfig) { return; } var plausibleDomain = 'news-medical.net'; window.plausible = window.plausible || function () {(window.plausible.q = window.plausible.q || []).push(arguments)}; var a = document.createElement('script'); a.type = 'text/javascript'; a.defer = true; a.setAttribute('data-domain', plausibleDomain); a.src = 'https://plausible.io/js/script.manual.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(a, s); $(function () { Azom.recordPlausiblePageview(); }); } </script> <script type="text/javascript"> //<![CDATA[ window.g_bSuppressSideSponsor = true; window.g_Have160Tower = false; window.g_Have300Tower = false; window.iScreenWidth = 0; // 0 = normal, 1 = wider, 2 = widest window.g_windowWidth = 0; window.g_towerPromoSpotRightPos = 0; g_windowWidth = window.innerWidth || (!document.documentElement ? 0 : document.documentElement.clientWidth) || (!document.body ? 0 : document.body.clientWidth) || (!document.body ? 0 : document.body.offsetWidth); //var screenWidthCss = ""; if (!g_bSuppressSideSponsor) { if (g_Have300Tower && g_windowWidth >= 1450) { iScreenWidth = 2; //screenWidthCss = "widest-screen-for-right-block"; g_towerPromoSpotRightPos = ((g_windowWidth - 1100) / 2) - 300 - 20; } else if (g_Have160Tower && g_windowWidth >= 1310) { iScreenWidth = 1; //screenWidthCss = "wide-screen-for-right-block"; g_towerPromoSpotRightPos = ((g_windowWidth - 1100) / 2) - 160 - 20; } } window.g_haveDesktopLeaderboardWidth = window.matchMedia("(min-width: 750px)").matches; window.g_haveSidebarWidth = window.matchMedia("(min-width: 992px)").matches; window.g_canShowAdSense = window.g_noAdSense === false && (g_haveSidebarWidth || window.g_havePublishable); window.g_displayableSlots = { desktopLeaderboard: g_haveDesktopLeaderboardWidth, desktopSquares: g_haveSidebarWidth, mobileTopLeaderboard: !g_haveDesktopLeaderboardWidth, mobileBottomLeaderboard: !g_haveDesktopLeaderboardWidth, mobileMiddleMrec: !g_haveSidebarWidth, mobileBottomMrec: !g_haveSidebarWidth, csi590x80: g_haveDesktopLeaderboardWidth, csi300x370: g_haveSidebarWidth }; //]]> </script> <script type="application/ld+json"> { "@context": "http://schema.org", "@type": "Organization", "name": "News-Medical", "url": "https://www.news-medical.net/", "logo": "https://www.news-medical.net/themes/Standard/images/full_site_logo.png", "sameAs": [ "https://www.facebook.com/NewsMedical", "https://twitter.com/NewsMedical" ] } </script> <script type="application/ld+json"> { "@context": "http://schema.org", "@type": "WebSite", "name": "News-Medical", "url": "https://www.news-medical.net/", "potentialAction": { "@type": "SearchAction", "target": "https://www.news-medical.net/medical/search?q={search_term_string}", "query-input": "required name=search_term_string" } } </script> <meta name="description" content="Laboratory experiments with cancer cells reveal two ways in which tumors evade drugs designed to starve and kill them, a new study shows." /><meta name="keywords" content="Cancer, Chemotherapy, Apoptosis, Cell, Cell Death, Cell Metabolism, DNA, Drugs, Genes, Genetic, Glucose, Laboratory, Medicine, Metabolism, Mitochondria, Nucleotide, Nucleotides, Pathology, Pyrimidine, Research, RNA, Tumor" /></head> <body class="site-body sharebox-pending-init site-section-medical active-menu-medical promo-item-pending with-tmdrw"> <script type="text/javascript"> var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; window.g_areSiteAdsInitialized = false; window.g_displayAdsToRender = []; function pushDisplayAd(fn) { if (window.g_areSiteAdsInitialized) { googletag.cmd.push(fn); } else { window.g_displayAdsToRender.push(fn); } } </script> <script type="text/javascript"> window.g_ear = true; </script> <script async="async" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script> <script type="text/javascript"> var g_dfpSlots = []; if (g_displayableSlots.desktopLeaderboard) { g_dfpSlots.push({ps: [728, 90], szs: [728, 90], aduid: '/1005779/News-Medical728x90Top', noasaduid: '/1005779/News-Medical728x90Top_NoAS', eid: 'div-gpt-top-leaderboard', sced: false, refresh: true }); } if (g_displayableSlots.desktopSquares) { g_dfpSlots.push({ps: [300, 250], szs: [[300, 600], [160, 600], [300, 250]], aduid: '/1005779/NewsMedicalSquares', noasaduid: '/1005779/NewsMedicalSquares_NoAS', eid: 'div-gpt-mrec', sced: false, refresh: true }); } if (g_displayableSlots.mobileTopLeaderboard) { var g_adTop320Available = g_windowWidth >= 320; var g_adTopSizes = g_adTop320Available ? ([[320, 50], [300, 50]]) : ([300, 50]); if (!g_adTop320Available) { $(function() { $('#div-gpt-mobile-top-leaderboard').closest('.mobile-promo-wrap').removeClass("mobile-promo-leaderboard-320").addClass("mobile-promo-leaderboard-300"); }); } g_dfpSlots.push({ps: (g_adTop320Available ? [320, 50] : [300, 50]), szs: g_adTopSizes, aduid: '/1005779/Mobile320x50Top', noasaduid: '/1005779/Mobile320x50Top_NoAS', eid: 'div-gpt-mobile-top-leaderboard', sced: false, refresh: true }); } if (g_displayableSlots.mobileMiddleMrec) { g_dfpSlots.push({ps: [300, 250], szs: [300, 250], aduid: '/1005779/MobileMREC3MID', noasaduid: '/1005779/MobileMREC3MID_NoAS', eid: 'div-gpt-mobile-middle-mrec', sced: true }); } if (g_displayableSlots.mobileBottomLeaderboard) { var g_adBottom320Available = g_windowWidth >= 320; var g_adBottomSizes = g_adBottom320Available ? ([[320, 50], [300, 50]]) : ([300, 50]); if (!g_adBottom320Available) { $(function() { $('#div-gpt-mobile-bottom-leaderboard').closest('.mobile-promo-wrap').removeClass("mobile-promo-leaderboard-320").addClass("mobile-promo-leaderboard-300"); }); } g_dfpSlots.push({ps: (g_adBottom320Available ? [320, 50] : [300, 50]), szs: g_adBottomSizes, aduid: '/1005779/Mobile320x50Bottom', noasaduid: '/1005779/Mobile320x50Bottom_NoAS', eid: 'div-gpt-mobile-bottom-leaderboard', sced: true, refresh: true }); } </script> <script type='text/javascript'> //<![CDATA[ window._renderedAdSlots = []; var g_dfpTargeting = [ { k: "site", v: "nm" }, { k: "excldcmpgn", v: ["2916","2917","2918","2919","2920","2921","2922","2923"] } ]; function initSiteAds() { if (!window.g_canShowAdSense) { for (var s = 0; s < g_dfpSlots.length; s++) { var slot = g_dfpSlots[s]; if (slot.noasaduid && slot.aduid !== slot.noasaduid) { slot.aduid = slot.noasaduid; } } } g_dfpTargeting.push({ k: "hostname", v: window.location.hostname }); if (!window.g_isTargetingEnabled) { g_dfpTargeting.push({ k: "npa", v: "yes" }); } googletag.cmd.push(function () { for (var s = 0; s < g_dfpSlots.length; s++) { var slot = g_dfpSlots[s]; if (slot.oop) { slot.slotObj = googletag.defineOutOfPageSlot(slot.aduid, slot.eid).addService(googletag.pubads()); } else { slot.slotObj = googletag.defineSlot(slot.aduid, slot.szs, slot.eid).addService(googletag.pubads()); if (slot.sced) { slot.slotObj.setCollapseEmptyDiv(true); } } } if (g_dfpTargeting.length) { for (var t = 0; t < g_dfpTargeting.length; t++) { googletag.pubads().setTargeting(g_dfpTargeting[t].k, g_dfpTargeting[t].v); } } (function(){for(var d=function(a){for(var b="",c=0;c<a.length /2;c++)b+=String.fromCharCode(parseInt(a.substr(2*c,2),16)^43);return b},a=[],b=0;b<g_azopgtg.length;b++)a.push(d(g_azopgtg[b]));googletag.pubads().setTargeting(a[0],a.splice(1))})(); if (!window.g_isIabTcfInUse && !g_isIabGppInUse && !window.g_isTargetingEnabled) { googletag.pubads().setPrivacySettings({ 'restrictDataProcessing': true, 'nonPersonalizedAds': true }); } googletag.pubads().addEventListener('slotRenderEnded', function (e) { if (typeof Azom === 'undefined') { _renderedAdSlots.push(e); } else { Azom.onAdSlotRendered(e); } }); if (g_windowWidth < 992) { googletag.pubads().enableLazyLoad({ fetchMarginPercent: 120, renderMarginPercent: 120, mobileScaling: window.g_ear ? 1.5 : 1.1 }); } googletag.pubads().enableSingleRequest(); googletag.enableServices(); }); //////////////// if (typeof g_displayAdsToRender !== 'undefined' && g_displayAdsToRender.length) { while (g_displayAdsToRender.length) { var item = g_displayAdsToRender.shift(); googletag.cmd.push(item); item = null; } } //////////////// window.g_areSiteAdsInitialized = true; } //]]> </script> <script type="text/javascript"> window.g_azoReadCookie = function (name) { var nameEQ = name + "="; var ca = document.cookie.split(';'); for (var i = 0; i < ca.length; i++) { var c = ca[i]; while (c.charAt(0) == ' ') c = c.substring(1, c.length); if (c.indexOf(nameEQ) == 0) return c.substring(nameEQ.length, c.length); } return null; }; function updateGoogleConsentModeUserPreferences() { var cp = typeof BlogEngine === 'object' ? BlogEngine.getVisitorCookieAndPrivacyPreferences() : null; var performance = (cp ? cp.performance : window.g_isPerformanceEnabled) ? true : false; var functional = (cp ? cp.functional : window.g_isFunctionalEnabled) ? true : false; var targeting = (cp ? cp.targeting : window.g_isTargetingEnabled) ? true : false; gtag('consent', 'update', { 'ad_storage': targeting ? 'granted' : 'denied', 'analytics_storage': performance ? 'granted' : 'denied', 'functionality_storage': functional ? 'granted' : 'denied', 'personalization_storage': targeting ? 'granted' : 'denied', 'security_storage': 'granted', 'ad_user_data': targeting ? 'granted' : 'denied', 'ad_personalization': targeting ? 'granted' : 'denied' }); } function canRunPerformanceAnalytics() { if ((window.g_enableAnalytics && !g_azoReadCookie('isstffvstr')) || g_azoReadCookie('analytics-on')) { return true; } else { return false; } } if (canRunPerformanceAnalytics() && typeof initPlausible === 'function') { initPlausible(); } window.g_hasActionsOnConsentsAvailableRun = false; function actionsOnConsentsAvailable() { if (window.g_hasActionsOnConsentsAvailableRun) { return; } window.g_hasActionsOnConsentsAvailableRun = true; var cp = ''; if (window.g_cmpKind === 2) { cp = (OnetrustActiveGroups.includes('C0002') ? '1' : '0') + (OnetrustActiveGroups.includes('C0003') ? '1' : '0') + (OnetrustActiveGroups.includes('C0004') ? '1' : '0'); } else { cp = g_azoReadCookie('cookiepolicy'); } if (cp && cp.length !== 3) { cp = null; } var isCookieBarShown = cp ? false : !!g_azoReadCookie('cookiebarshown'); var currentCookieNoticeBarStatus = 0; function configureCookieNoticeBar() { if (window.g_cmpKind !== 1) { return; } if (cp) { return; } var showFullBar = typeof bStrictCookies === 'boolean' && bStrictCookies; var newCookieNoticeBarStatus = showFullBar ? 2 : 1; if (currentCookieNoticeBarStatus === newCookieNoticeBarStatus) { return; } try { var root = document.getElementsByTagName('html')[0]; if (root && root.classList) { root.classList.toggle('show-cookie-bar', true); root.classList.toggle('show-cookie-bar-standard', !showFullBar); root.classList.toggle('show-cookie-bar-full', showFullBar); currentCookieNoticeBarStatus = newCookieNoticeBarStatus; } } catch (e) { } } var areCookieCategoriesSet = false; function evaluateCookiePolicyStatus() { if (areCookieCategoriesSet) { return; } var canSetCookieCategories = false; if (window.g_cmpKind !== 1) { canSetCookieCategories = true; } else { canSetCookieCategories = g_cookiePolicyStatus === 1 || g_cookiePolicyStatus === 2 || (g_cookiePolicyStatus === 3 && typeof bStrictCookies === 'boolean'); } if (canSetCookieCategories) { if (window.g_cmpKind !== 1) { window.g_isTargetingEnabled = cp[2] === '1'; window.g_isPerformanceEnabled = cp[0] === '1'; window.g_isFunctionalEnabled = cp[1] === '1'; } else { window.g_isTargetingEnabled = (cp && cp[2] === '1') || (!bStrictCookies && !cp && isCookieBarShown); window.g_isPerformanceEnabled = (cp && cp[0] === '1') || (!bStrictCookies && !cp && isCookieBarShown); window.g_isFunctionalEnabled = (cp && cp[1] === '1') || (!bStrictCookies && !cp && isCookieBarShown); } areCookieCategoriesSet = true; updateGoogleConsentModeUserPreferences(); if (canRunPerformanceAnalytics()) { initAnalytics(); } if (typeof initSiteAds === 'function') { initSiteAds(); } $(function() { BlogEngine.incrementTopicUpdateNotificationPageCounter(); BlogEngine.loadConsentDependentScripts(); if (bRecordClientView && typeof contentViewData !== 'undefined') { Azom.recordClientView(); } else { } Azom.loadAdSenseAds(); window.g_trendMdJournalId = '87497'; Azom.loadTrendMd(); Azom.checkInboundDetails(); }); } } function evaluateGeoLocation(location) { var country = ''; var region = ''; if (window.g_cmpKind === 2) { var otLocationData = OneTrust.getGeolocationData(); country = !otLocationData ? '' : (otLocationData.country || '').toString().toUpperCase(); region = !otLocationData ? '' : (otLocationData.state || '').toString().toUpperCase(); } else if (location) { country = (location.country || '').toString().toUpperCase(); region = (location.region || '').toString().toUpperCase(); } else { country = (g_azoReadCookie('azocountry') || '').toString(); } if (typeof country === 'string' && country.length === 2) { window.g_countryCode = country.toUpperCase(); window.g_regionCode = region.toUpperCase(); if (window.g_countryCode === 'GB' && window.g_canShowAdSense) { window.g_canShowAdSense = false; } window.bStrictCookies = window.g_countryCode === 'DE'; if (window.g_cmpKind === 1) { $(function () { Azom.createCookie("azocountry", country, 0); BlogEngine.initCookieNoticeBar(); }); } } configureCookieNoticeBar(); evaluateCookiePolicyStatus(); } function onGetCountryProblem() { window.bStrictCookies = true; evaluateCookiePolicyStatus(); } function lookupCountryIfNeeded() { if (window.g_cmpKind !== 1) { return; } if (window.g_countryCode) { } if (!window.g_countryCode) { if (typeof fetch === 'undefined') { onGetCountryProblem(); } else { fetch('/cdn-cgi/trace') .then(function (resp) { return resp.text(); }) .then(function (data) { var foundCountry = false; if (!data || typeof data !== 'string') { } else { var match = data.match(/\bloc=([a-z]{2})/i); if (!match || !match.length || match.length < 2) { } else { foundCountry = true; evaluateGeoLocation({ country: match[1], region: null }); } } if (!foundCountry) { onGetCountryProblem(); } }) .catch(function (error) { onGetCountryProblem(); }); } } } ///////////////// if (window.g_cmpKind === 1) { if (cp) { window.g_cookiePolicyStatus = 1; } else if (!isCookieBarShown) { window.g_cookiePolicyStatus = 2; } else { window.g_cookiePolicyStatus = 3; } } evaluateGeoLocation(null); lookupCountryIfNeeded(); } </script> <script> </script> <script> </script> <script src="https://cdn-ukwest.onetrust.com/scripttemplates/otSDKStub.js" async type="text/javascript" charset="UTF-8" data-domain-script="f362e18d-20d8-4df3-ba3d-631ebffb71e2" ></script> <script type="text/javascript"> window.g_isOneTrustAvailable = false; window.g_areInitialOneTrustConsentsAvailable = false; window.g_oneTrustRequireBannerInteraction = false; function OptanonWrapper() { if (!window.g_isOneTrustAvailable) { window.g_isOneTrustAvailable = true; if (typeof window.__tcfapi === 'function') { window.g_isIabTcfInUse = true; } if (typeof window.__gpp === 'function') { window.g_isIabGppInUse = true; } } if (window.g_areInitialOneTrustConsentsAvailable) { $(function () { BlogEngine.onOneTrustConsentsUpdated(); }); } else { $(function () { var isBoxClosed = !!Azom.readCookie('OptanonAlertBoxClosed'); if (!window.g_areInitialOneTrustConsentsAvailable) { var isBannerOverlayVisible = $('.ot-fade-in').is(':visible'); var areConsentsAvailableForProcessing = !isBannerOverlayVisible || isBoxClosed; if (!areConsentsAvailableForProcessing) { window.g_oneTrustRequireBannerInteraction = true; } else { window.g_areInitialOneTrustConsentsAvailable = true; window.setTimeout(actionsOnConsentsAvailable, 1); } } }); } } </script> <div id="body-wrap"> <div id="wide-screen-container"> <div class="page-wrap"> <div class="container main-content-left"> <form method="post" action="/news/20241126/Study-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx" id="aspnetForm"> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="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" /> </div> <script type="text/javascript"> //<![CDATA[ function registerVariables(){BlogEngine.webRoot='/';BlogEngine.i18n.hasRated='You already rated this article';BlogEngine.i18n.savingTheComment='Saving the comment...';BlogEngine.i18n.comments='Comments';BlogEngine.i18n.commentWasSaved='The comment was saved. Thank you for the feedback';BlogEngine.i18n.commentWaitingModeration='Thank you for the feedback. The comment is now awaiting moderation';BlogEngine.i18n.cancel='Cancel';BlogEngine.i18n.filter='Filter';BlogEngine.i18n.apmlDescription='Enter the URL to your website or to your APML document';BlogEngine.i18n.beTheFirstToRate='Be the first to rate this article';BlogEngine.i18n.currentlyRated='Currently rated {0} by {1} {2}';BlogEngine.i18n.ratingHasBeenRegistered='Your rating has been registered. Thank you!';BlogEngine.i18n.rateThisXStars='Rate this {0} star{1} out of 5';};//]]> </script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="AD7AD114" /> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="KQ/T0ug9AF4Qu1foleMxOZhA8+FYdbTkBU/tIChXLg3RaSA0BntpCyGQ8yOavYh2maiZMbeO2nbHkdyHncvgNJSJ3VSqqu8BaHkTR+24bzhBic2DNYsGU3BLZNjjQgIMAeo2uZOCArtJGLkoFnytAfVsrpPGZKgzi5Z/2lRvDrEqky0MhTFMgwN7hsE9omd4SuGPw5ZCwyZWLh80rrPXBJPe988=" /> </div> <div class='overlay-content-wrapper'> <div id='social-login-overlay-simple-container'></div> <div id='social-login-overlay-full-container' class='mfp-with-anim'></div> </div> <header> <a class="skip-link sr-only sr-only-focusable" href="#main">Skip to content</a> <nav class="main-menu container menu-container"> <div class="logo col-sm-2 col-xs-12"> <a href="/"> <picture> <source srcset="https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/nm-logo-4-@2x.png 2x, https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/nm-logo-4-@3x.png 3x, https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/nm-logo-4.png" media="(min-width: 768px)" width="143" height="75" /> <source srcset="https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/news_medical_and_life_sciences_logo_1000w.png 2x, https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/news_medical_and_life_sciences_logo_600w.png" media="(max-width: 767px)" width="600" height="56" /> <img class="img-responsive center-block" src="https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/nm-logo-4.png" alt="News-Medical" width="143" height="75" /> </picture> </a> </div> <div class="mobile-moremenu-wrap visible-xs-block"> <a class="moremenu mobile-menu"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M16 132h416c8.837 0 16-7.163 16-16V76c0-8.837-7.163-16-16-16H16C7.163 60 0 67.163 0 76v40c0 8.837 7.163 16 16 16zm0 160h416c8.837 0 16-7.163 16-16v-40c0-8.837-7.163-16-16-16H16c-8.837 0-16 7.163-16 16v40c0 8.837 7.163 16 16 16zm0 160h416c8.837 0 16-7.163 16-16v-40c0-8.837-7.163-16-16-16H16c-8.837 0-16 7.163-16 16v40c0 8.837 7.163 16 16 16z"/></svg> <span class="sr-only">Menu</span> </a> </div> <div class="nav-right col-sm-10 col-xs-12"> <div class="user-menu"> <div class="row"> <div class="col-sm-7 hidden-xs site-sections-menu-wrap"> <div class="site-sections-menu"> <a href="/medical" class="site-section-menu-btn-medical active-site-sections-menu-btn">Medical Home</a> <a href="/life-sciences" class="site-section-menu-btn-life-sciences">Life Sciences Home</a> </div> <div class="an-azonetwork-site"><a class="an-azonetwork-site" href="/suppliers/AZoNetwork-UK-Ltd.aspx"><img src="https://d2jx2rerrg6sh3.cloudfront.net/images/an-azonetwork-site.svg" alt="An AZoNetwork Site" width="158" height="16" /></a></div> </div> <div class="col-sm-5 col-xs-12 menu-top-right"> <div class="user-info"> <a href="/azoprofile/login/" onclick="return AZoProfileUtils.showAZoProfileLoginFullOverlay(null, null);" class="login-signup"><span>Become a Member</span></a> <div id='profile-login-content' class='profile-login-content'></div>  </div> <div class="search-input-group input-group"> <span class="icon-search"></span> <input aria-labelledby="searchLabel" type="search" id="globalSearchField" class="form-control searchfield" placeholder="Search..." maxlength="200" value="" data-search-btn-selector="#globalSearchButton" /> <div class="input-group-addon search-btn-wrap"> <button class="search-btn" onclick="return BlogEngine.search('globalSearchField');" onkeypress="return BlogEngine.search('globalSearchField');"> <span aria-hidden="true" class="icon-arrow-right"></span> <span id="searchLabel" class="sr-only">Search</span> </button> </div> </div> </div> </div> </div> <ul aria-hidden="true" class="menu main-nav-menu top-nav-menu-medical"> <li class="hidden-sm hidden-md hidden-lg mobile-menu-medical-home"><a href="/medical"><span>Medical Home</span></a></li> <li class="hidden-sm hidden-md hidden-lg mobile-menu-life-sciences-home"><a href="/life-sciences"><span>Life Sciences Home</span></a></li> <li><a href="/medical/about"><span>About</span></a></li> <li><a href="/condition/Coronavirus-Disease-COVID-19"><span>COVID-19</span></a></li> <li><a href="/medical/news"><span>News</span></a></li> <li><a class="content-hub-link" href="/medical-a-z.aspx"><span>Health A-Z</span></a></li> <li><a href="/drugs-a-z.aspx"><span>Drugs</span></a></li> <li><a href="/Clinical-and-Diagnostics"><span>Medical Devices</span></a></li> <li><a href="/medical/interviews"><span>Interviews</span></a></li> <li class="menu-item-on-wide-device"><a href="/medical/whitepapers"><span>White Papers</span></a></li> <li class="hidden-xs"><a class="moremenu">More...</a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/mediknowledge"><span>MediKnowledge</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/ebooks"><span>eBooks</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/posters"><span>Posters</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/podcasts"><span>Podcasts</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/newsletters"><span>Newsletters</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/Consumer-Products"><span>Health & Personal Care</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/contact"><span>Contact</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/team"><span>Meet the Team</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/advertise"><span>Advertise</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/search"><span>Search</span></a></li> <li class="hidden-sm hidden-md hidden-lg mobile-menu-profile-become-member"> <a href="/azoprofile/login/" onclick="return AZoProfileUtils.showAZoProfileLoginFullOverlay(null, null);" class="login-signup"><span>Become a Member</span></a> </li> </ul> <div class="hub-menu-desktop medical-hub-menu"> <h2>Top Health Categories</h2> <div class="row"> <div class="col-xs-4"> <ul class="hub-menu-items"> <li class="hub-menu-item"> <a href="/condition/Coronavirus-Disease-COVID-19">Coronavirus Disease COVID-19</a></li> <li class="hub-menu-item"> <a href="/condition/Diet-Nutrition">Diet & Nutrition</a></li> <li class="hub-menu-item"> <a href="/condition/Artificial-Intelligence">Artificial Intelligence</a></li> <li class="hub-menu-item"> <a href="/condition/Allergies">Allergies</a></li> <li class="hub-menu-item"> <a href="/condition/Alzheimers-Dementia">Alzheimer's & Dementia</a></li> <li class="hub-menu-item"> <a href="/condition/Arthritis-Rheumatology">Arthritis & Rheumatology</a></li> <li class="hub-menu-item"> <a href="/condition/Breast-Cancer">Breast Cancer</a></li> </ul> </div> <div class="col-xs-4"> <ul class="hub-menu-items"> <li class="hub-menu-item"> <a href="/condition/Cold-Flu-Cough">Cold, Flu & Cough</a></li> <li class="hub-menu-item"> <a href="/condition/Eating-Disorders">Eating Disorders</a></li> <li class="hub-menu-item"> <a href="/condition/Eye-Health">Eye Health</a></li> <li class="hub-menu-item"> <a href="/condition/Gastrointestinal-Health">Gastrointestinal Health</a></li> <li class="hub-menu-item"> <a href="/condition/Heart-Disease">Heart Disease</a></li> <li class="hub-menu-item"> <a href="/condition/High-Blood-Pressure">High Blood Pressure</a></li> <li class="hub-menu-item"> <a href="/condition/Lung-Cancer">Lung Cancer</a></li> </ul> </div> <div class="col-xs-4"> <ul class="hub-menu-items"> <li class="hub-menu-item"> <a href="/condition/Mental-Health">Mental Health</a></li> <li class="hub-menu-item"> <a href="/condition/Mpox">Mpox</a></li> <li class="hub-menu-item"> <a href="/condition/Pregnancy">Pregnancy</a></li> <li class="hub-menu-item"> <a href="/condition/Type-1-Diabetes">Type 1 Diabetes</a></li> <li class="hub-menu-item"> <a href="/condition/Type-2-Diabetes">Type 2 Diabetes</a></li> <li class="hub-menu-item"> <a href="/condition/Sexual-Health">Sexual Health</a></li> <li class="hub-menu-item"> <a href="/condition/Sleep">Sleep</a></li> <li class="hub-menu-item"> <a class="view-all-topics" href="/medical-a-z.aspx">View Health A-Z</a></li> </ul> </div> </div> </div> <div class="hub-menu-mobile medical-hub-menu-mobile"> <h2><span class="close-mobile-hub-menu">×</span>Top Health Categories</h2> <ul class="menu"> <li><a href="/condition/Coronavirus-Disease-COVID-19"><span>Coronavirus Disease COVID-19</span></a></li> <li><a href="/condition/Heart-Disease"><span>Heart Disease</span></a></li> <li><a href="/condition/Diet-Nutrition"><span>Diet & Nutrition</span></a></li> <li><a href="/condition/High-Blood-Pressure"><span>High Blood Pressure</span></a></li> <li><a href="/condition/Artificial-Intelligence"><span>Artificial Intelligence</span></a></li> <li><a href="/condition/Lung-Cancer"><span>Lung Cancer</span></a></li> <li><a href="/condition/Allergies"><span>Allergies</span></a></li> <li><a href="/condition/Mental-Health"><span>Mental Health</span></a></li> <li><a href="/condition/Alzheimers-Dementia"><span>Alzheimer's & Dementia</span></a></li> <li><a href="/condition/Mpox"><span>Mpox</span></a></li> <li><a href="/condition/Arthritis-Rheumatology"><span>Arthritis & Rheumatology</span></a></li> <li><a href="/condition/Pregnancy"><span>Pregnancy</span></a></li> <li><a href="/condition/Breast-Cancer"><span>Breast Cancer</span></a></li> <li><a href="/condition/Type-1-Diabetes"><span>Type 1 Diabetes</span></a></li> <li><a href="/condition/Cold-Flu-Cough"><span>Cold, Flu & Cough</span></a></li> <li><a href="/condition/Type-2-Diabetes"><span>Type 2 Diabetes</span></a></li> <li><a href="/condition/Eating-Disorders"><span>Eating Disorders</span></a></li> <li><a href="/condition/Sexual-Health"><span>Sexual Health</span></a></li> <li><a href="/condition/Eye-Health"><span>Eye Health</span></a></li> <li><a href="/condition/Sleep"><span>Sleep</span></a></li> <li><a href="/condition/Gastrointestinal-Health"><span>Gastrointestinal Health</span></a></li> <li class="empty-listitem"><span> </span></li> </ul> <div class="hub-menu-view-all-topics"> <a id="hypViewAllMobile" href="/medical-a-z.aspx">View Health A-Z</a> </div> </div> <ul aria-hidden="true" class="menu main-nav-menu top-nav-menu-life-sciences"> <li class="hidden-sm hidden-md hidden-lg mobile-menu-medical-home"><a href="/medical"><span>Medical Home</span></a></li> <li class="hidden-sm hidden-md hidden-lg mobile-menu-life-sciences-home"><a href="/life-sciences"><span>Life Sciences Home</span></a></li> <li><a href="/life-sciences/about"><span>About</span></a></li> <li><a href="/life-sciences/news"><span>News</span></a></li> <li><a href="/life-sciences-a-z"><span>Life Sciences A-Z</span></a></li> <li><a href="/life-sciences/whitepapers"><span>White Papers</span></a></li> <li><a href="/Life-Science-and-Laboratory"><span>Lab Equipment</span></a></li> <li><a href="/life-sciences/interviews"><span>Interviews</span></a></li> <li><a href="/life-sciences/newsletters"><span>Newsletters</span></a></li> <li class="menu-item-on-wide-device"><a href="/life-sciences/webinars"><span>Webinars</span></a></li> <li class="hidden-xs"><a class="moremenu">More...</a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/life-sciences/ebooks"><span>eBooks</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/life-sciences/posters"><span>Posters</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/life-sciences/podcasts"><span>Podcasts</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/life-sciences/contact"><span>Contact</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/life-sciences/team"><span>Meet the Team</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/life-sciences/advertise"><span>Advertise</span></a></li> <li class="hidden-sm hidden-md hidden-lg"><a href="/medical/search"><span>Search</span></a></li> <li class="hidden-sm hidden-md hidden-lg mobile-menu-profile-become-member"> <a href="/azoprofile/login/" onclick="return AZoProfileUtils.showAZoProfileLoginFullOverlay(null, null);" class="login-signup"><span>Become a Member</span></a> </li> </ul> <div class="sub-menu col-xs-12" aria-role="nav"> <ul class="mobile-main mobile-main-medical serif hidden-xs"> <li class="menu-item-on-wide-device"><a href="/medical/whitepapers">White Papers</a></li> <li><a href="/mediknowledge">MediKnowledge</a></li> <li><a href="/medical/ebooks">eBooks</a></li> <li><a href="/medical/posters">Posters</a></li> <li><a href="/medical/podcasts">Podcasts</a></li> <li><a href="/medical/newsletters"><span>Newsletters</span></a></li> <li><a href="/Consumer-Products"><span>Health & Personal Care</span></a></li> <li><a href="/medical/contact">Contact</a></li> <li><a href="/medical/team">Meet the Team</a></li> <li><a href="/medical/advertise">Advertise</a></li> <li><a href="/medical/search">Search</a></li> <li class="mobile-menu-profile-become-member"> <a href="/azoprofile/login/" onclick="return AZoProfileUtils.showAZoProfileLoginFullOverlay(null);" class="login-signup"><span>Become a Member</span></a> </li> </ul> <ul class="mobile-main mobile-main-life-sciences serif hidden-xs"> <li class="menu-item-on-wide-device"><a href="/life-sciences/webinars"><span>Webinars</span></a></li> <li><a href="/life-sciences/ebooks"><span>eBooks</span></a></li> <li><a href="/life-sciences/posters"><span>Posters</span></a></li> <li><a href="/life-sciences/podcasts"><span>Podcasts</span></a></li> <li><a href="/life-sciences/contact"><span>Contact</span></a></li> <li><a href="/life-sciences/team">Meet the Team</a></li> <li><a href="/life-sciences/advertise"><span>Advertise</span></a></li> <li><a href="/medical/search"><span>Search</span></a></li> <li class="mobile-menu-profile-become-member"> <a href="/azoprofile/login/" onclick="return AZoProfileUtils.showAZoProfileLoginFullOverlay(null);" class="login-signup"><span>Become a Member</span></a> </li> </ul> </div> </div> </nav> </header> <div class="clearfix"> <div id="top-banner-ad" class="banner-ad"> <div id='top-promo-spot'> <div id='div-gpt-top-leaderboard'> <script type='text/javascript'> //<![CDATA[ if (g_displayableSlots.desktopLeaderboard) { pushDisplayAd(function () { googletag.display('div-gpt-top-leaderboard'); }); } //]]> </script> </div> </div> </div> </div> <main id="main" tabindex="-1" class="main-container col-xs-12 col-md-8"> <script type="text/javascript"> //<![CDATA[ var PdfReq = { itemType: 'news', itemName: 'Study reveals how cancer cells evade chemotherapy in low-glucose environments', languageCode: '', formTitle: 'Study reveals how cancer cells evade chemotherapy in low-glucose environments Printable Document (PDF)', itemId: 796766 }; $(function () { Azom.initPdfReqPage(); }); //]]> </script> <div style="position:absolute;visibility:hidden;"> <div id="pdfReqForm" class="azoForm-dialog azoForm-desktop-container mfp-with-anim"> <div class="pdfReq-form-dialog-container-contents"></div> </div> </div> <div id="pdfReqFormMobileContainerOnPage" class="azoForm-mobile-container"> </div> <input type="hidden" id="url-to-share" value="https://www.news-medical.net/news/20241126/Study-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx"/> <div class="share-box"> <ul class="showEmailShare"> <li class="pdf-download no-count"> <a href="#" class="request-pdf-download" title="Download PDF copy"> <div class="share-wrapper"> <div aria-hidden="true" class="icon icon-download"></div> </div> </a> </li> <li class="sidebar-ratings"> <a id="star-rating-link" class="star-rating-link" onclick="return Azom.displayRatingsSlider(this);" title="Rating"> <div class="share-wrapper"> <div aria-hidden="true" class="icon icon-star-full"></div> <div class="count count-ratings"></div> </div> </a> <div class="ratingcontainer" style="visibility:hidden" data-id="7cf6ecfd-7727-4869-b25a-cdb234425d01" data-raters="1" data-rating="5.0" data-page-location="SocialIconsSidebar"></div> </li> <li class="linkedin"> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https%3a%2f%2fwww.news-medical.net%2fnews%2f20241126%2fStudy-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx&title=" title="LinkedIn" data-win-width="520" data-win-height="570" target="_blank"> <div class="share-wrapper"> <div aria-hidden="true" class="icon icon-linkedin"></div> <div class="count count-linkedin"></div> </div> </a> </li> <li class="facebook"> <a href="https://www.facebook.com/sharer/sharer.php?u=https%3a%2f%2fwww.news-medical.net%2fnews%2f20241126%2fStudy-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx" title="Facebook" data-win-width="550" data-win-height="600" target="_blank"> <div class="share-wrapper"> <div aria-hidden="true" class="icon icon-facebook"></div> <div class="count count-facebook"></div> </div> </a> </li> <li class="twitter no-count"> <a href="https://x.com/share?url=https%3a%2f%2fwww.news-medical.net%2fnews%2f20241126%2fStudy-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx&text=" title="X" data-win-width="550" data-win-height="300" target="_blank"> <div class="share-wrapper"> <div aria-hidden="true" class="icon icon-twitter-x"></div> </div> </a> </li> <li class="reddit no-count"> <a href="https://www.reddit.com/submit?url=https%3a%2f%2fwww.news-medical.net%2fnews%2f20241126%2fStudy-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx" title="Reddit" data-win-width="575" data-win-height="600" target="_blank"> <div class="share-wrapper"> <div aria-hidden="true" class="icon icon-reddit"></div> </div> </a> </li> <li class="pinterest no-count"> <a href="http://pinterest.com/pin/create/button/?url=https%3a%2f%2fwww.news-medical.net%2fnews%2f20241126%2fStudy-reveals-how-cancer-cells-evade-chemotherapy-in-low-glucose-environments.aspx" title="Pinterest" target="_blank"> <div class="share-wrapper"> <div aria-hidden="true" class="icon icon-pinterest"></div> </div> </a> </li> <li class="email no-count"> <a href="#" onclick="return Azom.displayShareViaEmail();" title="Email" target="_blank"> <div class="share-wrapper"> <div aria-hidden="true" class="icon icon-envelop"></div> </div> </a> </li> </ul> </div> <div class="item-body content-item-body"> <div class="h1-wrap"> <h1 id="h1-7cf6ecfd-7727-4869-b25a-cdb234425d01" itemprop="headline" class="page-title">Study reveals how cancer cells evade chemotherapy in low-glucose environments</h1> </div> <div class="in-content-ctas-container in-content-ctas-container-top in-content-ctas-container-with-reviewers-notes"> <div class="in-content-ctas in-content-ctas-top cta-btns-cols-1"> <ul> <li class="cta-printpdf"><a href="#" class="request-pdf-download" onclick="return false;"><span class="cta-text"><span>Download</span> <span>PDF Copy</span></span></a></li> </ul> </div> <div class="article-status-details"> <img src="https://d2jx2rerrg6sh3.cloudfront.net/images/editorial-checklist.svg" alt="Editorial Checklist" width="129" height="150" /> <a href="#" tabindex="0" class="reviewed-indicator" data-content="<p><img src="https://d2jx2rerrg6sh3.cloudfront.net/image.axd?picture=2017%2f1%2fchemotherapy_IV_drug_-_NATHAPON_PANGJAI__a1585a4d29f84741a3fd1fea9df0fb9b-80x70.jpg" alt="" width="80" height="70" /> This article has been provided by <a href="https://nyulangone.org/" target="_blank" rel="noopener nofollow">NYU Langone Health</a> and subjected to News-Medical.Net's <a href="/medical/content-policy">review protocols</a>, complying with its guidelines. To guarantee the article's authority, our editing team has highlighted the following features: verified accuracy, undergone scholarly review, sourced from a reliable authority, and meticulously scrutinized for errors. Modifications may be made to the article's style and length.</p>">Reviewed</a> </div> </div> <div class="overlay-content-wrapper"> <div class="reviewers-notes-modal"> <div class="reviewers-notes-body item-body"> <div class="reviewers-notes-content"> </div> <div class="reviewers-notes-close-wrap"> <input class="reviewers-notes-close close-reviewers-notes-button" type="button" value="Close" /> </div> </div> </div> </div> <div class="content"> <div id="body-7cf6ecfd-7727-4869-b25a-cdb234425d01" class="page-content clearfix" itemprop="articleBody"> <div id="mobile-top-promo-spot" class="mobile-promo-wrap mobile-promo-leaderboard-320"> <div class="mobile-promo-item sponsorer-note-bottom" id='div-gpt-mobile-top-leaderboard' style='width:320px; min-height:65px; text-align: center;'> <script type='text/javascript'> if (g_displayableSlots.mobileTopLeaderboard) { pushDisplayAd(function() { googletag.display('div-gpt-mobile-top-leaderboard'); }); } </script> </div> </div><div class="article-meta article-meta-byline"><span class="article-meta-contents"><span class="article-meta-left"><span class="article-meta-source"><a href="https://nyulangone.org/" rel="noopener">NYU Langone Health</a></span></span><span class="article-meta-right article-meta-right-with-date article-meta-right-one-item"><span class="article-meta-date">Nov 26 2024</span></span></span></div><span itemprop="author" itemscope itemtype="http://schema.org/Organization"><meta itemprop="name" content="News Medical" /><meta itemprop="url" content="https://www.news-medical.net/" /></span> <p>Laboratory experiments with cancer cells reveal two ways in which tumors evade drugs designed to starve and kill them, a new study shows.</p> <p>While chemotherapies successfully treat cancers and extend patients' lives, they are known not to work for everyone for long, as cancer cells rewire the process by which they convert fuel into energy (metabolism) to outmaneuver the drugs' effects. Many of these drugs are so-called antimetabolics, disrupting cell processes needed for tumor growth and survival.</p> <p>Three such drugs used in the study - raltitrexed, N-(phosphonacetyl)-l-aspartate (PALA), and brequinar - work to prevent cancer cells from making pyrimidines, molecules that are an essential component to genetic letter codes, or nucleotides, that make up RNA and DNA. Cancer cells must have access to pyrimidine supplies to produce more cancer cells and to produce uridine nucleotides, a primary fuel source for cancer cells as they rapidly reproduce, grow, and die. Disrupting the fast-paced but fragile pyrimidine synthesis pathways, as some chemotherapies are designed to do, can rapidly starve cancer cells and spontaneously lead to them dying (apoptosis).</p> <p>Led by researchers at NYU Langone Health and its Perlmutter Cancer Center, the new study shows how cancer cells survive in an environment made hostile by the persistent shortage of the energy from glucose (the chemical term for blood sugar) needed to drive tumor growth. This better understanding of how cancer cells evade the drugs' attempts to kill them in a low-glucose environment, the researchers say, could lead to the design of better or more effective combination therapies.</p> <p>Publishing in the journal <em>Nature Metabolism</em> online Nov. 26, study results showed that the low-glucose environment inhabited by cancer cells, or tumor microenvironment, stalls cancer cell consumption of existing uridine nucleotide stores, making the chemotherapies less effective.</p> <p>Normally, uridine nucleotides would be made and consumed to help make the genetic letter codes and fuel cell metabolism. But when DNA and RNA construction is blocked by these chemotherapies, so too is the consumption of uridine nucleotide pools, the researchers found, as glucose is needed to change one form of uridine, UTP, into another usable form, UDP-glucose. The irony, researchers say, is that a low-glucose tumor microenvironment is in turn slowing down cellular consumption of uridine nucleotides and presumably slowing down rates of cell death. Researchers say cancer cells need to run out of pyrimidine building blocks, including uridine nucleotides, before the cells will self-destruct.</p> <p>In other experiments, low-glucose tumor microenvironments were also unable to activate two proteins, BAX and BAK, sitting on the surface of mitochondria, a cell's fuel generator. Activation of these trigger proteins disintegrates the mitochondria, and instantly sets off a series of caspase enzymes that help initiate apoptosis (cell death).</p> <blockquote> <p>Our study shows how cancer cells manage to offset the impact of low-glucose tumor microenvironments, and how these changes in cancer cell metabolism minimize chemotherapy's effectiveness."</p> <p style="text-align: right;">Minwoo Nam, PhD, study lead investigator, postdoctoral fellow in the Department of Pathology at NYU Grossman School of Medicine and Perlmutter Cancer Center</p> </blockquote> <p>"Our results explain what has until now been unclear about how the altered metabolism of the tumor microenvironment impacts chemotherapy: low glucose slows down the consumption and exhaustion of uridine nucleotides needed to fuel cancer cell growth and hinders resulting apoptosis, or death, in cancer cells," said senior study investigator Richard Possemato, PhD. Possemato is an associate professor in the Department of Pathology at NYU Grossman School of Medicine and also a member of Perlmutter Cancer Center.</p><div id="mobile-middle-mrec-promo-spot" class="mobile-promo-wrap mobile-promo-mrec"> <div class="mobile-promo-item sponsorer-note-bottom" id='div-gpt-mobile-middle-mrec' style='width:300px; height:250px;'> <script type='text/javascript'> if (g_displayableSlots.mobileMiddleMrec) { pushDisplayAd(function() { googletag.display('div-gpt-mobile-middle-mrec'); }); } </script> </div> </div>  <p>Possemato, who is also coleader of the Cancer Cell Biology Program at Perlmutter, says his team's study results could one day be used to develop chemotherapies or combination therapies that would change or trick cancer cells into responding the same way in a low-glucose microenvironment as they would in an otherwise stable glucose microenvironment.</p> <div id="trendmd-conditional-suggestions" class="related-content-embed"></div><div class="related-content-embed related-stories-embed"><h3>Related Stories</h3><ul><li><a href="/news/20250222/Medicare-patients-with-cancer-often-receive-aggressive-treatment-over-supportive-care.aspx">Medicare patients with cancer often receive aggressive treatment over supportive care</a></li><li><a href="/news/20250225/Early-lung-cancer-diagnosis-improved-with-ctDNA-methylation-biomarkers.aspx">Early lung cancer diagnosis improved with ctDNA methylation biomarkers</a></li><li><a href="/news/20250224/Study-challenges-role-of-BRCA1-mutation-in-prostate-cancer-initiation.aspx">Study challenges role of BRCA1 mutation in prostate cancer initiation</a></li></ul></div><p>He also says that diagnostic tests could be developed to measure how a patient's cancer cells would most likely respond to low-glucose microenvironments and to predict how well a patient might respond to a particular chemotherapy.</p> <p>Possemato says his team has plans to investigate how blocking other cancer cell pathways might trigger apoptosis in response to these chemotherapies. Some experimental drugs, such as Chk-1 and ATR inhibitors, already exist that might accomplish this, he notes, but more need to be investigated because Chk-1 and ATR inhibitors are not well tolerated by patients.</p> <p>For the study, researchers performed a scan of 3,000 cancer cell genes known to be involved in cell metabolism to determine, by deletion, which were necessary for cancer cell survival after chemotherapy. Most of the genes they found that were essential to cell survival in low-glucose tumor environments were also involved in pyrimidine synthesis, a precise biological pathway targeted by many chemotherapies. This focused their experiments on how different lab-grown clones of cancer cells responded to low-glucose after chemotherapy and what other chemical processes were impacted by depressed sugar levels.</p> <p>Funding support for the study was provided by National Institutes of Health grants P30CA016087, R01CA286141, R01CA214948, R01GM132491, R35GM139610. Additional funding support came from the Pew Charitable Trusts, Alexander and Margaret Stewart Trust, and the American Cancer Society.</p> <p>Besides Nam and Possemato, other NYU Langone researchers involved in this study are co-investigators Wenxin Xia, Abdul Hannan Mir, and Tony Huang.</p> <div id="mobile-bottom-promo-spot" class="mobile-promo-wrap mobile-promo-leaderboard-320"> <div class="mobile-promo-item sponsorer-note-bottom" id='div-gpt-mobile-bottom-leaderboard' style='width:320px; min-height:50px; text-align: center;'> <script type='text/javascript'> if (g_displayableSlots.mobileBottomLeaderboard) { pushDisplayAd(function() { googletag.display('div-gpt-mobile-bottom-leaderboard'); }); } </script> </div> </div><div id="sources" class="content-source below-content-common-a"><div class="content-src-label">Source:</div><div class="content-src-value"><p><a href="https://nyulangone.org/" rel="noopener">NYU Langone Health</a></p></div><div class="content-src-label">Journal reference:</div><div class="content-src-value"><p>Nam, M., <em>et al.</em> (2024). Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition. <em>Nature Metabolism</em>. <a href="https://doi.org/10.1038/s42255-024-01166-w" rel="noopener">doi.org/10.1038/s42255-024-01166-w</a>.</p></div></div> </div> </div> <div class="outside-content-zone below-content"> <div class="ratingcontainer" style="visibility:hidden" data-id="7cf6ecfd-7727-4869-b25a-cdb234425d01" data-raters="1" data-rating="5.0" data-page-location="BottomOfContent"></div> <p class="categories">Posted in: <a href="/category/Cell-Biology.aspx">Cell Biology</a> | <a href="/category/Medical-Research-News.aspx">Medical Research News</a> | <a href="/category/Medical-Condition-News.aspx">Medical Condition News</a></p> <p class="tags">Tags: <a href="/?tag=/Apoptosis" rel="tag">Apoptosis</a>, <a href="/?tag=/Blood" rel="tag">Blood</a>, <a href="/?tag=/Blood-Sugar" rel="tag">Blood Sugar</a>, <a href="/condition/Cancer" rel="tag">Cancer</a>, <a href="/?tag=/Cell" rel="tag">Cell</a>, <a href="/?tag=/Cell-Biology" rel="tag">Cell Biology</a>, <a href="/?tag=/Cell-Death" rel="tag">Cell Death</a>, <a href="/?tag=/Cell-Metabolism" rel="tag">Cell Metabolism</a>, <a href="/condition/Chemotherapy" rel="tag">Chemotherapy</a>, <a href="/?tag=/Diagnostic" rel="tag">Diagnostic</a>, <a href="/?tag=/DNA" rel="tag">DNA</a>, <a href="/?tag=/Drugs" rel="tag">Drugs</a>, <a href="/?tag=/Exhaustion" rel="tag">Exhaustion</a>, <a href="/?tag=/Genes" rel="tag">Genes</a>, <a href="/?tag=/Genetic" rel="tag">Genetic</a>, <a href="/?tag=/Glucose" rel="tag">Glucose</a>, <a href="/?tag=/Laboratory" rel="tag">Laboratory</a>, <a href="/?tag=/Medicine" rel="tag">Medicine</a>, <a href="/condition/Metabolism" rel="tag">Metabolism</a>, <a href="/?tag=/Mitochondria" rel="tag">Mitochondria</a>, <a href="/?tag=/Nucleotide" rel="tag">Nucleotide</a>, <a href="/?tag=/Nucleotides" rel="tag">Nucleotides</a>, <a href="/?tag=/Pathology" rel="tag">Pathology</a>, <a href="/?tag=/Pyrimidine" rel="tag">Pyrimidine</a>, <a href="/?tag=/Research" rel="tag">Research</a>, <a href="/?tag=/RNA" rel="tag">RNA</a>, <a href="/?tag=/Tumor" rel="tag">Tumor</a></p> <div style="display:none;" itemprop="publisher" itemscope itemtype="https://schema.org/Organization"> <div itemprop="logo" itemscope itemtype="https://schema.org/ImageObject"> <meta itemprop="url" content="https://www.news-medical.net/themes/Standard/images/amp_site_logo.jpg" /> <meta itemprop="width" content="600" /> <meta itemprop="height" content="56" /> </div> <meta itemprop="name" content="News-Medical" /> <meta itemprop="url" content="https://www.news-medical.net/" /> </div> <div class="below-content-footer"> <div class="right snap-suppress-first-snap-network-delimiter"> <a href="#commentblock">Comments (0)</a> </div> </div> </div> <div class="in-content-ctas-container in-content-ctas-container-bottom"> <div class="in-content-ctas in-content-ctas-bottom cta-btns-cols-1"> <ul> <li class="cta-printpdf"><a href="#" class="request-pdf-download" onclick="return false;"><span class="cta-text"><span>Download</span> <span>PDF Copy</span></span></a></li> </ul> </div> </div> <div class="csi-590-80-wrap"> <ins class="adsbygoogle csi-590-80 sponsorer-note-bottom-2" style="display:inline-block;" data-ad-client="ca-pub-8430344808469242" data-ad-slot="6986242780"></ins> </div> </div> <div id="trendmd-suggestions"></div> <div class="recommended-content below-content-recommends"> <h2>Suggested Reading</h2> <div class="col-xs-12 col-ms-4 col-sm-3 col-md-3 recommended-item"><div class="col-xs-4 col-ms-12 col-sm-12 rc-img"><a href="/news/20250228/First-ever-clinical-trials-evaluate-fenofibrate-as-treatment-for-HPV-related-cancers.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/7/Cholesterol-125x110.jpg" alt="First-ever clinical trials evaluate fenofibrate as treatment for HPV-related cancers" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-12 col-sm-12 rc-text"><div><a href="/news/20250228/First-ever-clinical-trials-evaluate-fenofibrate-as-treatment-for-HPV-related-cancers.aspx">First-ever clinical trials evaluate fenofibrate as treatment for HPV-related cancers</a></div></div></div><div class="col-xs-12 col-ms-4 col-sm-3 col-md-3 recommended-item"><div class="col-xs-4 col-ms-12 col-sm-12 rc-img"><a href="/news/20250225/Breast-cancer-cases-and-deaths-set-to-surge-by-2050e28094are-we-prepared.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/news/ImageForNews_803331_457137526668634245969-125x110.jpg" alt="Breast cancer cases and deaths set to surge by 2050—are we prepared?" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-12 col-sm-12 rc-text"><div><a href="/news/20250225/Breast-cancer-cases-and-deaths-set-to-surge-by-2050e28094are-we-prepared.aspx">Breast cancer cases and deaths set to surge by 2050—are we prepared?</a></div></div></div><div class="col-xs-12 col-ms-4 col-sm-3 col-md-3 recommended-item"><div class="col-xs-4 col-ms-12 col-sm-12 rc-img"><a href="/news/20250225/Study-reveals-ferulic-acids-potential-in-preventing-colon-cancer.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2016/3/Colon_cancer_-_Sebastian_Kaulitzki_-_590_251fd9699da6402a9035de6194cb89bf-125x110.jpg" alt="Study reveals ferulic acid's potential in preventing colon cancer" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-12 col-sm-12 rc-text"><div><a href="/news/20250225/Study-reveals-ferulic-acids-potential-in-preventing-colon-cancer.aspx">Study reveals ferulic acid's potential in preventing colon cancer</a></div></div></div><div class="col-xs-12 col-ms-4 col-sm-3 col-md-3 recommended-item"><div class="col-xs-4 col-ms-12 col-sm-12 rc-img"><a href="/news/20250228/AI-detects-colorectal-cancer-with-high-accuracy.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2016/6/Cancer_cell_attacked_by_lymphocytes-Juan_Gaertner-590_faf73e6bdc1340739a87109231bebac5-125x110.jpg" alt="AI detects colorectal cancer with high accuracy" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-12 col-sm-12 rc-text"><div><a href="/news/20250228/AI-detects-colorectal-cancer-with-high-accuracy.aspx">AI detects colorectal cancer with high accuracy</a></div></div></div><div class="col-xs-12 col-ms-4 col-sm-3 col-md-3 recommended-item"><div class="col-xs-4 col-ms-12 col-sm-12 rc-img"><a href="/news/20250226/Scientists-pioneer-fecal-transplant-capsules-to-enhance-pancreatic-cancer-treatment.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2015/3/Pancreatic_Cancer_89a89cdc7f804d5b8329b646f86bbec6-125x110.jpg" alt="Scientists pioneer fecal transplant capsules to enhance pancreatic cancer treatment" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-12 col-sm-12 rc-text"><div><a href="/news/20250226/Scientists-pioneer-fecal-transplant-capsules-to-enhance-pancreatic-cancer-treatment.aspx">Scientists pioneer fecal transplant capsules to enhance pancreatic cancer treatment</a></div></div></div><div class="col-xs-12 col-ms-4 col-sm-3 col-md-3 recommended-item"><div class="col-xs-4 col-ms-12 col-sm-12 rc-img"><a href="/news/20250224/Study-unravels-the-complex-interplay-of-the-UPS-in-cancer-development-and-treatment.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/7/174318220-125x110.jpg" alt="Study unravels the complex interplay of the UPS in cancer development and treatment" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-12 col-sm-12 rc-text"><div><a href="/news/20250224/Study-unravels-the-complex-interplay-of-the-UPS-in-cancer-development-and-treatment.aspx">Study unravels the complex interplay of the UPS in cancer development and treatment</a></div></div></div><div class="col-xs-12 col-ms-4 col-sm-3 col-md-3 recommended-item"><div class="col-xs-4 col-ms-12 col-sm-12 rc-img"><a href="/news/20250224/Study-finds-key-p53-targets-for-future-cancer-treatment.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2018/8/shutterstock_158445182_07334b221bcb45af81579fa86e0f5519-125x110.jpg" alt="Study finds key p53 targets for future cancer treatment" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-12 col-sm-12 rc-text"><div><a href="/news/20250224/Study-finds-key-p53-targets-for-future-cancer-treatment.aspx">Study finds key p53 targets for future cancer treatment</a></div></div></div><div class="col-xs-12 col-ms-4 col-sm-3 col-md-3 recommended-item"><div class="col-xs-4 col-ms-12 col-sm-12 rc-img"><a href="/news/20250222/Development-of-lymphoma-following-CAR-T-cell-therapy.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2019/5/Cancer_cell_3D_-_Illustration_-_Nedelcu_Paul_Petru_A1_d7692bd1e41f4bfc8fd26a4ae5434c2f-125x110.jpg" alt="Development of lymphoma following CAR-T cell therapy" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-12 col-sm-12 rc-text"><div><a href="/news/20250222/Development-of-lymphoma-following-CAR-T-cell-therapy.aspx">Development of lymphoma following CAR-T cell therapy</a></div></div></div> </div> <div id="commentblock"> <h2>Comments</h2> <div id="commentsBlockWrapper" style="display:none;"> <div id='comments-wrap'> </div> </div> <div class="commentDisclaimer"> The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical. </div> <script type='text/javascript'> $(function() { BlogEngine.initComments(); }); </script> <div id="comment-form-bottom-holder"> <div id="comment-form"> <div class="commentForm"> <input type="hidden" name="ctl00$cphBody$CommentView1$hiddenReplyTo" id="hiddenReplyTo" /> <p id="cancelReply" style="display:none;"><a href="javascript:void(0);" onclick="BlogEngine.cancelReply();">Cancel reply to comment</a></p> <div id='comment-status'></div> <div class='azoprofile-identity-box-wrap'> <div class='azoprofile-identity-box-pic'> <img alt='' src='/pics/anonymous_avatar.gif' /> </div> <div class='azoprofile-identity-box-right'> <div id='azoprofile-identity-box-top'>Post a new comment</div> <div class='azoprofile-identity-box-login-wrap'> <a href='#' class='azoprofile-identity-box-login-btn'> <span class='azoprofile-identity-box-login-text'>Login</span> <span class='azoprofile-identity-box-provider-icons'> </span> <span class='azoprofile-identity-box-button'><span class='azoprofile-identity-box-button-arrow'> </span></span> </a> </div> <div class='azoprofile-identity-box-loggedin'> <div class='azoprofile-identity-box-name'></div> <div class='azoprofile-identity-box-logout'><a href='#' onclick='return AZoProfileUtils.onAZoProfileBoxIdentityLogout();'>(Logout)</a></div> </div> </div> </div> <div style='clear:both;'></div> <div class='comment-title'> <label class="sr-only" for="tbCommentTitle">Quirky Comment Title</label> <input name="ctl00$cphBody$CommentView1$tbCommentTitle" type="text" maxlength="150" id="tbCommentTitle" tabindex="1" /> </div> <div id="commentCompose"> <textarea name="ctl00$cphBody$CommentView1$tbCommentBody" rows="2" cols="20" id="tbCommentBody" tabindex="7" aria-labelledby="azoprofile-identity-box-top"> </textarea> </div> <a id="post-comment" href="#" onclick="return false;" class="comment-btn">Post</a> <div style="clear:both;"></div> </div> </div> </div> <script type="text/javascript"> var currentCommentItemTypeId = 1; var currentCommentItemId = '7cf6ecfd-7727-4869-b25a-cdb234425d01'; </script> </div> <script type="text/javascript"> //<![CDATA[ var g_topicNotify = { itemType: 'News', itemId: 796766, allTags: [{k:1666,v:'Chemotherapy',cbp:true},{k:2029,v:'Cancer',cbp:true},{k:591,v:'Cell Metabolism',cbp:true},{k:3165,v:'Mitochondria',cbp:true},{k:3941,v:'Nucleotides',cbp:true},{k:4708,v:'Cell Death',cbp:true},{k:3453,v:'Laboratory',cbp:true},{k:433,v:'Metabolism',cbp:true},{k:3061,v:'Nucleotide',cbp:true},{k:3903,v:'Pyrimidine',cbp:true},{k:500,v:'Apoptosis',cbp:true},{k:1500,v:'Pathology',cbp:true},{k:4902,v:'Medicine',cbp:true},{k:4537,v:'Research',cbp:true},{k:2845,v:'Genetic',cbp:true},{k:4694,v:'Glucose',cbp:true},{k:2784,v:'Drugs',cbp:true},{k:2844,v:'Genes',cbp:true},{k:2672,v:'Tumor',cbp:true},{k:345,v:'Cell',cbp:true},{k:207,v:'DNA',cbp:true},{k:814,v:'RNA',cbp:true},{k:4712,v:'Cell Biology',cbp:false},{k:1862,v:'Blood Sugar',cbp:false},{k:5812,v:'Diagnostic',cbp:false},{k:4800,v:'Exhaustion',cbp:false},{k:2892,v:'Blood',cbp:false}] }; //]]> </script> <div id="topic-notification-signup-box"></div> <span itemprop="image" itemscope itemtype="https://schema.org/ImageObject"><meta itemprop="url" content="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/7/Chemo_Vials-620x480.jpg" /><meta itemprop="width" content="620" /><meta itemprop="height" content="480" /><meta itemprop="caption" content="Study reveals how cancer cells evade chemotherapy in low-glucose environments" /><span itemprop="thumbnail" itemscope itemtype="https://schema.org/ImageObject"><meta itemprop="url" content="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/ts/20140702013238/ri/200/picture/2014/7/Chemo_Vials-620x480.jpg" /><meta itemprop="width" content="200" /><meta itemprop="height" content="155" /></span></span> </main> <div class="sidebar-container main-sidebar-container col-xs-12 col-md-4"> <div id="widgetzone_CommonSidebarTopV3" class="widgetzone clearfix"><section class="widget literal clearfix sidebar-mrec-wrap" id="widgetefe51110-d5fa-4d0a-919e-aca0876dcf2d"> <div id='div-gpt-mrec' class='sponsorer-note-bottom'> <script type='text/javascript'> //<![CDATA[ if (g_displayableSlots.desktopSquares) { pushDisplayAd(function() { googletag.display('div-gpt-mrec'); }); } //]]> </script> </div> </section></div> <section class="tab-container col-xs-12"> <ul class="nav nav-tabs nav-sidebar-tabs" data-tabs="tabs"> <li class="active"><a href="#tabs-1" data-toggle="tabs"><span>Trending<br />Stories</span></a></li> <li><a href="#tabs-2" data-toggle="tabs"><span>Latest<br />Interviews</span></a></li> <li><a href="#tabs-3" data-toggle="tabs"><span>Top Health<br />Articles</span></a></li> </ul> <div class="tab-content"> <div id="tabs-1" class="tab-pane active interviews-container col-xs-12"> <div id="widgetzone_CommonTabsTab1V3" class="widgetzone clearfix"><section class="widget mostpopularcontent clearfix common-img-list-outer" id="widget7ad6f03a-884f-4d11-a272-92e79503fdce"><ul class="common-img-list most-popular-content common-img-list-with-thumbs"><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250224/Trump-froze-out-project-2025-in-his-campaign-Now-its-blueprint-is-his-health-care-playbook.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2016/3/Children_playing_sunset_-_Zurijeta_-_590_d411ed33e37d4e1ca8d09174a2235c2c-125x110.jpg" alt="Trump froze out project 2025 in his campaign. Now its blueprint is his health care playbook." style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250224/Trump-froze-out-project-2025-in-his-campaign-Now-its-blueprint-is-his-health-care-playbook.aspx" class="common-img-list-text">Trump froze out project 2025 in his campaign. Now its blueprint is his health care playbook.</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250224/Normal-vitamin-B12-levels-may-not-prevent-brain-decline.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/news/ImageForNews_803105_45711940753541672339-125x110.jpg" alt=""Normal" vitamin B12 levels may not prevent brain decline" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250224/Normal-vitamin-B12-levels-may-not-prevent-brain-decline.aspx" class="common-img-list-text">"Normal" vitamin B12 levels may not prevent brain decline</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250224/New-service-could-cut-hospital-admissions-for-older-adults-and-save-NHS-money.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/7/Hospital3-125x110.jpg" alt="New service could cut hospital admissions for older adults and save NHS money" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250224/New-service-could-cut-hospital-admissions-for-older-adults-and-save-NHS-money.aspx" class="common-img-list-text">New service could cut hospital admissions for older adults and save NHS money</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250225/With-RFK-Jr-in-charge-supplement-makers-see-chance-to-cash-in.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2017/4/Accident_Injury_Information_Report_Health-Rawpixel.com_ac5524c1031e4229bc369a9a2a504d1c-125x110.jpg" alt="With RFK Jr. in charge, supplement makers see chance to cash in" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250225/With-RFK-Jr-in-charge-supplement-makers-see-chance-to-cash-in.aspx" class="common-img-list-text">With RFK Jr. in charge, supplement makers see chance to cash in</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250226/Research-shows-exercise-can-delay-Alzheimere28099s-but-theree28099s-a-catch.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/news/ImageForNews_803459_45714844418495374197-125x110.jpg" alt="Research shows exercise can delay Alzheimer’s, but there’s a catch" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250226/Research-shows-exercise-can-delay-Alzheimere28099s-but-theree28099s-a-catch.aspx" class="common-img-list-text">Research shows exercise can delay Alzheimer’s, but there’s a catch</a></div></li></ul><div style="clear:both;"></div></section></div> </div> <div id="tabs-2" class="tab-pane equipment-container col-xs-12"> <div id="widgetzone_CommonTabsTab2V3" class="widgetzone clearfix"><section class="widget latestinterviews clearfix" id="widget0a18bf04-26a0-4353-91bb-048d62a7b2fa"><article class="article-size-3 interview col-xs-12"> <a href="/news/20250226/Microphysiological-systems-in-drug-discovery.aspx"><div class="article-title col-xs-9 col-md-8"> <h3>Microphysiological systems in drug discovery</h3> <p class="hidden-sm">Emily Richardson</p> <p class="visible-sm-block">NewsMedical speaks with CN Bio about the translatability between in vitro organ-on-a-chip (OOC) models, microphysiological systems, and their in vivo counterparts.</p> </div> <div class="article-thumb col-xs-3 col-md-4"> <img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/news/InterviewImageForNews_796788_17337454886132504.jpg" alt="Microphysiological systems in drug discovery" style="height:110px;" /></div> </a> </article> <article class="article-size-3 interview col-xs-12"> <a href="/news/20250224/Considerations-for-taking-ASO-discovery-programs-into-animal-models.aspx"><div class="article-title col-xs-9 col-md-8"> <h3>Considerations for taking ASO discovery programs into animal models</h3> <p class="hidden-sm">Susanne Back</p> <p class="visible-sm-block">ALS therapy can be drastically advanced with the help of ASOs.</p> </div> <div class="article-thumb col-xs-3 col-md-4"> <img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/news/InterviewImageForNews_793229_17394610906626967.jpg" alt="Considerations for taking ASO discovery programs into animal models" style="height:110px;" /></div> </a> </article> <article class="article-size-3 interview col-xs-12"> <a href="/news/20250221/Neurofilament-light-as-a-translational-biomarker-from-preclinical-drug-discovery-to-clinical-application.aspx"><div class="article-title col-xs-9 col-md-8"> <h3>Neurofilament light as a translational biomarker</h3> <p class="hidden-sm">Phillip Mitchell</p> <p class="visible-sm-block">Neurofilament light (NFL) is a powerful and sensitive biomarker for tracking neuronal health and disease progression.</p> </div> <div class="article-thumb col-xs-3 col-md-4"> <img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/news/InterviewImageForNews_794350_17394597250491472.jpg" alt="Neurofilament light as a translational biomarker" style="height:110px;" /></div> </a> </article> </section></div> </div> <div id="tabs-3" class="tab-pane col-xs-12"> <div id="widgetzone_CommonTabsTab3V3" class="widgetzone clearfix"><section class="widget mostpopularcontent clearfix common-img-list-outer" id="widget360d1ace-7707-41de-b785-fe14029ab139"><ul class="common-img-list most-popular-content common-img-list-with-thumbs"><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/health/The-Carnivore-Diet-Healthy-Trend-or-Risky-Fad.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/Article_Images/ImageForArticle_25816_4571222509968754718-125x110.jpg" alt="Is The Carnivore Diet Healthy?" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/health/The-Carnivore-Diet-Healthy-Trend-or-Risky-Fad.aspx" class="common-img-list-text">Is The Carnivore Diet Healthy?</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/health/Whats-Next-for-Semaglutide-Beyond-Diabetes-and-Weight-Loss.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/Article_Images/ImageForArticle_25767_45698226391504634209-125x110.jpg" alt="What's Next for Semaglutide? Beyond Diabetes and Weight Loss" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/health/Whats-Next-for-Semaglutide-Beyond-Diabetes-and-Weight-Loss.aspx" class="common-img-list-text">What's Next for Semaglutide? Beyond Diabetes and Weight Loss</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/health/The-Truth-About-Mushroom-Coffee-Benefits-vs-Hype.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/Article_Images/ImageForArticle_25801_4570816695964123397-125x110.jpg" alt="The Truth About Mushroom Coffee: Benefits vs. Hype" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/health/The-Truth-About-Mushroom-Coffee-Benefits-vs-Hype.aspx" class="common-img-list-text">The Truth About Mushroom Coffee: Benefits vs. Hype</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/health/CRISPR-Based-Diagnostics-The-Future-of-Disease-Detection.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/Article_Images/ImageForArticle_25736_45685506081689815838-125x110.jpg" alt="CRISPR-Based Diagnostics: The Future of Disease Detection" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/health/CRISPR-Based-Diagnostics-The-Future-of-Disease-Detection.aspx" class="common-img-list-text">CRISPR-Based Diagnostics: The Future of Disease Detection</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/health/Alpha-GPC-What-Science-Says-About-Its-Role-in-Brain-Health.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/images/Article_Images/ImageForArticle_25791_45702246906331023641-125x110.jpg" alt="Alpha-GPC: What Science Says About Its Role in Brain Health" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/health/Alpha-GPC-What-Science-Says-About-Its-Role-in-Brain-Health.aspx" class="common-img-list-text">Alpha-GPC: What Science Says About Its Role in Brain Health</a></div></li></ul><div style="clear:both;"></div></section></div> </div> </div> </section> <div id="widgetzone_CommonSidebarBottomV3" class="widgetzone clearfix"><section class="widget literal clearfix csi-300-370-wrap" id="widgetcf3e21ae-b1e5-4816-82f4-b39f2abe23b3"> <div style="text-align:center;"> <ins class="adsbygoogle csi-300-370 sponsorer-note-bottom-2" style="display:inline-block;" data-ad-client="ca-pub-8430344808469242" data-ad-slot="9939709187"></ins> </div> </section><section class="widget recentposts clearfix common-img-list-outer" id="widget68b649b4-9400-4eb9-92fa-00d85cb74cf2"><h2 class="widget-top">Latest News</h2><ul class="common-img-list common-img-list-with-thumbs"><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250228/Study-demonstrates-successful-gene-therapy-for-maple-syrup-urine-disease.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/7/Gene_Therapy-125x110.jpg" alt="Study demonstrates successful gene therapy for maple syrup urine disease" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250228/Study-demonstrates-successful-gene-therapy-for-maple-syrup-urine-disease.aspx">Study demonstrates successful gene therapy for maple syrup urine disease</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250228/Study-identifies-barriers-to-sustaining-SNAP-Ed-programs-in-schools.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/6/Diet-125x110.jpg" alt="Study identifies barriers to sustaining SNAP-Ed programs in schools" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250228/Study-identifies-barriers-to-sustaining-SNAP-Ed-programs-in-schools.aspx">Study identifies barriers to sustaining SNAP-Ed programs in schools</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250228/New-chemical-reaction-enables-precise-functionalization-of-peptides-and-proteins.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2019/5/science%2c_chemistry%2c_biology%2c_medicine_and_people_concept_-_close_up_of_young_fem_-_Syda_Productions_M1_1e674058e745483caa7a7d4ed53e4396-125x110.jpg" alt="New chemical reaction enables precise functionalization of peptides and proteins" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250228/New-chemical-reaction-enables-precise-functionalization-of-peptides-and-proteins.aspx">New chemical reaction enables precise functionalization of peptides and proteins</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250228/Lactylation-in-the-heart-reveals-key-insights-into-cardiac-regeneration.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2014/7/Hospital3-125x110.jpg" alt="Lactylation in the heart reveals key insights into cardiac regeneration" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250228/Lactylation-in-the-heart-reveals-key-insights-into-cardiac-regeneration.aspx">Lactylation in the heart reveals key insights into cardiac regeneration</a></div></li><li><div class="col-xs-4 col-ms-3 col-sm-2 col-md-5 common-img-list-img"><a href="/news/20250228/European-project-aims-to-develop-new-treatments-for-rare-eye-diseases.aspx"><img class="lazy-load-image" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2017/2/Close_up_of_the_beautiful_eye_of_a_young_child_-_Nik_Bruining_f959060df7e6466ba2733a4c18153083-125x110.jpg" alt="European project aims to develop new treatments for rare eye diseases" style="height:110px;" /></a></div><div class="col-xs-8 col-ms-9 col-sm-10 col-md-7 common-img-list-text"><a href="/news/20250228/European-project-aims-to-develop-new-treatments-for-rare-eye-diseases.aspx">European project aims to develop new treatments for rare eye diseases</a></div></li></ul><div style="clear:both;"></div></section></div> <div class="sidebar-ebook-placeholder"></div> <script type="text/javascript"> $(function () { Azom.wireNewsletterPreviews(); }); </script> <script type="text/javascript"> $(function () { BlogEngine.initFixedPosition('#newsletter-content', '#newsletter-content-wrap', '.sidebar-container', 'main'); }); </script> <div id="newsletter-content-wrap"> <section id="newsletter-content" class="clearfix"> <h2>Newsletters you may be <span>interested in</span></h2> <ul> <li class="newsletter-widget-item newsletter-subscribe-item col-xs-12" data-include-subscribe-button="true" data-newsletter-id="145"> <div class="newsletter-icon-box col-xs-4 col-md-4"> <a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl0_hypImage" class="newsletter-preview-link" onclick="return false;" href="https://www.news-medical.net/newsletters/webview/?ppnid=145" target="_blank"><img id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl0_imgThumbnail" src="https://www.azonetwork.com/newsletters/icons/Genetics.png" alt="Genetics" /></a> </div> <div class="newsletter-item-name col-xs-8 col-md-8"> <a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl0_hypNewsletterName" class="newsletter-preview-link" onclick="return false;" aria-label="Genetics Newsletter" href="https://www.news-medical.net/newsletters/webview/?ppnid=145" target="_blank">Genetics</a> <div class="newsletter-item-preview"> (<a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl0_hypPreview" class="newsletter-preview-link" onclick="return false;" aria-label="Subscribe or Preview Genetics Newsletter" href="https://www.news-medical.net/newsletters/webview/?ppnid=145" target="_blank">Subscribe or Preview</a>) </div> </div> </li> <li class="newsletter-widget-item newsletter-subscribe-item col-xs-12" data-include-subscribe-button="true" data-newsletter-id="158"> <div class="newsletter-icon-box col-xs-4 col-md-4"> <a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl1_hypImage" class="newsletter-preview-link" onclick="return false;" href="https://www.news-medical.net/newsletters/webview/?ppnid=158" target="_blank"><img id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl1_imgThumbnail" src="https://www.azonetwork.com/newsletters/icons/Diabetes.png" alt="Diabetes" /></a> </div> <div class="newsletter-item-name col-xs-8 col-md-8"> <a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl1_hypNewsletterName" class="newsletter-preview-link" onclick="return false;" aria-label="Diabetes Newsletter" href="https://www.news-medical.net/newsletters/webview/?ppnid=158" target="_blank">Diabetes</a> <div class="newsletter-item-preview"> (<a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl1_hypPreview" class="newsletter-preview-link" onclick="return false;" aria-label="Subscribe or Preview Diabetes Newsletter" href="https://www.news-medical.net/newsletters/webview/?ppnid=158" target="_blank">Subscribe or Preview</a>) </div> </div> </li> <li class="newsletter-widget-item newsletter-subscribe-item col-xs-12" data-include-subscribe-button="true" data-newsletter-id="168"> <div class="newsletter-icon-box col-xs-4 col-md-4"> <a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl2_hypImage" class="newsletter-preview-link" onclick="return false;" href="https://www.news-medical.net/newsletters/webview/?ppnid=168" target="_blank"><img id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl2_imgThumbnail" src="https://www.azonetwork.com/newsletters/icons/Medical_Devices.png" alt="Medical Device" /></a> </div> <div class="newsletter-item-name col-xs-8 col-md-8"> <a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl2_hypNewsletterName" class="newsletter-preview-link" onclick="return false;" aria-label="Medical Device Newsletter" href="https://www.news-medical.net/newsletters/webview/?ppnid=168" target="_blank">Medical Device</a> <div class="newsletter-item-preview"> (<a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_ctrl2_hypPreview" class="newsletter-preview-link" onclick="return false;" aria-label="Subscribe or Preview Medical Device Newsletter" href="https://www.news-medical.net/newsletters/webview/?ppnid=168" target="_blank">Subscribe or Preview</a>) </div> </div> </li> </ul> <div class="footer"> <a id="ctl00_cphRightBottom_ucNewsletterWidget_lvNewsletters_hypSeeAllLink" href="/medical/newsletters">See all Newsletters »</a> </div> </section> </div> </div> <footer class="footer col-xs-12"> <div class="row footer-newsguard"> <div class="col-xs-12"> <div class="newsguard-logo-with-rating"> <a href="/medical/newsguard"> <img src="https://d2jx2rerrg6sh3.cloudfront.net/images/newsguard-logo.svg" width="300" height="47" alt="NewsGuard" /> <img src="https://d2jx2rerrg6sh3.cloudfront.net/images/newsguard-100.svg" width="300" height="65" alt="NewsGuard 100/100 Score" /> </a> </div> <div class="footer-newsguard-text"> High Credibility: This website adheres to all nine standards of credibility and transparency. </div> </div> </div> <div class="row footer-icons"> <div class="col-xs-12"> <a href="//privacy.truste.com/privacy-seal/validation?rid=80814776-9892-4bc0-a905-50180d9d0296" target="_blank"><img style="border: none" src="//privacy-policy.truste.com/privacy-seal/seal?rid=80814776-9892-4bc0-a905-50180d9d0296" width="142" height="45" alt="TRUSTe"/></a> <a href="https://registry.blockmarktech.com/certificates/b5720d0b-7698-4c0d-b58c-92920915c193/" target="_blank" class="ce-plus-badge"><img src="https://d2jx2rerrg6sh3.cloudfront.net/images/cyberessentials_plus_245x90.png" width="245" height="90" alt="Cyber Essentials Plus" /></a> </div> </div> <div class="row footer-top-row"> <div class="col-xs-12 col-ms-6 col-sm-6 col-md-3 footer-menu footer-menu-top-row-first-col"> <h3>Medical Links</h3> <nav aria-role="nav" class="row"> <ul> <li><a aria-label="Medical Home" href="/medical">Medical Home</a></li> <li><a aria-label="COVID-19" href="/condition/Coronavirus-Disease-COVID-19">COVID-19</a></li> <li><a aria-label="Medical News" href="/medical/news">News</a></li> <li><a aria-label="Health A-Z" href="/medical-a-z.aspx">Health A-Z</a></li> <li><a aria-label="Medical White Papers" href="/medical/whitepapers">White Papers</a></li> <li><a aria-label="Medical Thought Leaders" href="/medical/thought-leaders">Thought Leaders</a></li> <li><a aria-label="Medical Insights" href="/medical/insights-from-industry">Insights</a></li> <li><a aria-label="MediKnowledge Series" href="/mediknowledge">MediKnowledge Series</a></li> <li><a aria-label="Health & Personal Care" href="/Consumer-Products">Health & Personal Care</a></li> <li><a aria-label="Medical Devices" href="/Clinical-and-Diagnostics">Medical Devices</a></li> <li><a aria-label="Medical Drugs" href="/drugs-a-z.aspx">Drugs</a></li> <li><a aria-label="Medical eBooks" href="/medical/ebooks">eBooks</a></li> <li><a aria-label="Medical Posters" href="/medical/posters">Posters</a></li> <li><a aria-label="Medical Podcasts" href="/medical/podcasts">Podcasts</a></li> </ul> </nav> </div> <div class="col-xs-12 col-ms-6 col-sm-6 col-md-3 footer-menu footer-menu-top-row-second-col life-sciences-useful-links"> <h3>Life Sciences Links</h3> <nav aria-role="nav" class="row"> <ul> <li><a aria-label="Life Sciences Home" href="/life-sciences">Life Sciences Home</a></li> <li><a aria-label="Life Sciences News" href="/life-sciences/news">News</a></li> <li><a aria-label="Life Sciences Lab Instruments & Equipment" href="/Life-Science-and-Laboratory">Lab Instruments & Equipment</a></li> <li><a aria-label="Life Sciences A-Z" href="/life-sciences-a-z">Life Sciences A-Z</a></li> <li><a aria-label="Life Sciences White Papers" href="/life-sciences/whitepapers">White Papers</a></li> <li><a aria-label="Life Sciences Thought Leaders" href="/life-sciences/thought-leaders">Thought Leaders</a></li> <li><a aria-label="Life Sciences Insights" href="/life-sciences/insights-from-industry">Insights</a></li> <li><a aria-label="Life Sciences Webinars" href="/life-sciences/webinars">Webinars</a></li> <li><a aria-label="Life Sciences eBooks" href="/life-sciences/ebooks">eBooks</a></li> <li><a aria-label="Life Sciences Posters" href="/life-sciences/posters">Posters</a></li> <li><a aria-label="Life Sciences Podcasts" href="/life-sciences/podcasts">Podcasts</a></li> </ul> </nav> </div> <div class="col-xs-12 col-ms-6 col-sm-6 col-md-3 footer-menu footer-menu-top-row-third-col other-useful-links"> <h3>Other Useful Links</h3> <nav aria-role="nav" class="row"> <ul> <li><a aria-label="Medical About Us" href="/medical/about">About</a></li> <li><a aria-label="Medical Meet the Team" href="/medical/team">Meet the Team</a></li> <li><a aria-label="Medical Search" href="/medical/search">Search</a></li> <li><a aria-label="Medical Newsletters" href="/medical/newsletters">Newsletters</a></li> <li><a aria-label="Medical Section Sitemap" href="/sitemap.axd">Sitemap</a></li> <li><a aria-label="Medical Advertise" href="/medical/advertise">Advertise</a></li> <li><a aria-label="Medical Contact" href="/medical/contact">Contact</a></li> <li><a aria-label="Medical Terms & Conditions" href="/medical/terms">Terms & Conditions</a></li> <li><a aria-label="Medical Privacy & Cookie Policy" href="/medical/privacy">Privacy & Cookie Policy</a></li> <li><a aria-label="Medical Content Policy" href="/medical/content-policy">Content Policy</a></li> <li><a aria-label="Medical Ownership & Funding Information" href="/medical/about#ownership-funding">Ownership & Funding Information</a></li> </ul> </nav> </div> <div class="col-xs-12 col-ms-6 col-sm-6 col-md-3 footer-menu footer-menu-top-row-fourth-col azosites-menu-wrap"> <h3>Other AZoNetwork Sites</h3> <nav aria-role="nav" class="row"> <ul> <li><a aria-label="AZoM" href="https://www.azom.com/">AZoM</a></li> <li><a aria-label="AZoNano" href="https://www.azonano.com/">AZoNano</a></li> <li><a aria-label="AZoCleantech" href="https://www.azocleantech.com/">AZoCleantech</a></li> <li><a aria-label="AZoOptics" href="https://www.azooptics.com/">AZoOptics</a></li> <li><a aria-label="AZoRobotics" href="https://www.azorobotics.com/">AZoRobotics</a></li> <li><a aria-label="AZoSensors" href="https://www.azosensors.com/">AZoSensors</a></li> <li><a aria-label="AZoMining" href="https://www.azomining.com/">AZoMining</a></li> <li><a aria-label="AZoQuantum" href="https://www.azoquantum.com/">AZoQuantum</a></li> <li><a aria-label="AZoBuild" href="https://www.azobuild.com/">AZoBuild</a></li> <li><a aria-label="AZoLifeSciences" href="https://www.azolifesciences.com/">AZoLifeSciences</a></li> <li><a aria-label="AZoAi" href="https://www.azoai.com/">AZoAi</a></li> </ul> </nav> </div> </div> <div class="footer-matter col-xs-12"> <div class="footer-container"> <div class="center-block logo col-sm-3 col-xs-12"> <img src="https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/nm-logo-4.png" srcset="https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/nm-logo-4-@2x.png 2x, https://d2jx2rerrg6sh3.cloudfront.net/themes/Standard/images/nm-logo-4-@3x.png 3x" alt="News-Medical" /> <ul class="social"> <li> <a href="https://www.facebook.com/NewsMedical" aria-label="News-Medical Facebook page"> <span aria-hidden="true" class="icon-facebook"></span> <span class="sr-only">Facebook</span> </a> </li> <li> <a href="https://twitter.com/NewsMedical" aria-label="News-Medical Twitter page"> <span aria-hidden="true" class="icon-twitter-x"></span> <span class="sr-only">Twitter</span> </a> </li> <li> <a href="https://www.linkedin.com/company/news-medical/" aria-label="News-Medical LinkedIn page"> <span aria-hidden="true" class="icon-linkedin2"></span> <span class="sr-only">LinkedIn</span> </a> </li> </ul> </div> <div class="col-sm-9 col-xs-12 footer-matter-right"> <p class="site-disclaimer"> News-Medical.Net provides this medical information service in accordance with these <a href="/medical/terms">terms and conditions</a>. Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide. </p> <div class="footer-update-privacy-preferences"> <a onclick="BlogEngine.displayCookieSettings('Footer Link');"> <span class="update-privacy-preferences-lock-icon"></span> Update Your Privacy Preferences </a> </div> <p class="site-last-updated">Last Updated: Sunday 2 Mar 2025</p> </div> <div class="footer-matter-right-contents"> <p><a href="https://www.azonetwork.com/" target="_blank"><img src="https://www.azonetwork.com/images/azonetwork_logo_footer_80.png" alt="AZoNetwork"></a></p> <p>News-Medical.net - An AZoNetwork Site</p> <p>Owned and operated by AZoNetwork, © 2000-2025</p> </div> </div> </div> </footer>  <input type="hidden" name="ctl00$acChat$hdnApiDomain" id="hdnApiDomain" value="https://www.azoscience.com/" /> <input type="hidden" name="ctl00$acChat$hdnWebsiteName" id="hdnWebsiteName" value="NewsMedical" /> <input type="hidden" name="ctl00$acChat$hdnLoginRequiredForAzthenaChat" id="hdnLoginRequiredForAzthenaChat" value="true" /> <div class="chat-launcher-icon"> <button type="button" aria-label="Chat with Azthena" data-tooltip="Chat with our AI Assistant" data-tooltip-position="left" > <img src="https://d2jx2rerrg6sh3.cloudfront.net/images/ai-chat-icon.svg" alt="Azthena chat logo" /> </button> </div> <div class="chat-app-container" data-window-maximised="false" style="display:none;"> <header class="chat-app-header"> <div class="chat-logo"> <svg class="" id="azthenaicon" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 786.6 169.55" role="img" focusable="false"> <title>Azthena logo with the word Azthena</title> <g> <g> <path d="m23.48,49c-9.76,9.76-15.8,23.24-15.8,38.13,0,29.77,24.14,53.91,53.91,53.91,14.89,0,28.37-6.04,38.13-15.79-39.85-4.79-71.45-36.39-76.24-76.24h0Z"></path> <path d="m141.6,101.53c3.87-14.41,7.12-50.5-18.4-76.02-34.02-34.02-89.18-34.02-123.2,0l23.48,23.48c9.76-9.76,23.23-15.79,38.12-15.79,29.77,0,53.91,24.14,53.91,53.91,0,14.89-6.03,28.37-15.79,38.12l20.52,20.52,23.79,23.79s-14.44-23.33-2.43-68.02Z"></path> <path d="m247.38,42.42l32.48,70.27h-16.97l-5.31-13.01h-27.59l-5.31,13.01h-16.97l32.48-70.27h7.19Zm-3.54,23.63l-8.75,21.34h17.49l-8.75-21.34h0Z"></path> <path d="m356.84,42.94v3.75l-35.81,52.99h35.81v13.01h-58.61v-3.75l35.19-52.99h-32.9v-13.01s56.32,0,56.32,0Z"></path> <path d="m436,42.94v13.01h-22.28v56.43h-14.37v-56.43h-22.28v-13.01s58.93,0,58.93,0Z"></path> <path d="m474.36,42.94v28.42h32.38v-28.42h14.37v69.75h-14.37v-28.32h-32.38v28.32h-14.47V42.94h14.47Z"></path> <path d="m597.87,71.25v11.76h-30.82v16.87h34.88v12.81h-49.35V42.94h49.35v12.49h-34.88v15.82h30.82Z"></path> <path d="m692.34,42.94v70.27h-5.21l-41.33-42.58v42.06h-14.47V42.42h5.21l41.33,43.21v-42.68h14.47Z"></path> <path d="m754.12,42.42l32.48,70.27h-16.97l-5.31-13.01h-27.59l-5.31,13.01h-16.97l32.48-70.27h7.19Zm-3.54,23.63l-8.75,21.34h17.49l-8.75-21.34h.01Z"></path> </g> </g> </svg> </div> <div class="chat-container-actions"> <button type="button" id="maximise-minimise-button" class="expand-collapse-view" role="button" aria-label="Maximise chat window">  <svg class="icon icon-tabler icon-tabler-arrows-maximize" fill="none" height="24" stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" stroke-width="2" viewBox="0 0 24 24" width="24" xmlns="http://www.w3.org/2000/svg" role="img"> <title>Maximise chat window</title> <path d="M0 0h24v24H0z" fill="none" stroke="none"/><polyline points="16 4 20 4 20 8"/><line x1="14" x2="20" y1="10" y2="4"/><polyline points="8 20 4 20 4 16"/><line x1="4" x2="10" y1="20" y2="14"/><polyline points="16 20 20 20 20 16"/><line x1="14" x2="20" y1="14" y2="20"/><polyline points="8 4 4 4 4 8"/><line x1="4" x2="10" y1="4" y2="10"/></svg> </button> <button type="button" id="hide-chat-window" role="button" aria-label="Hide chat window"> <svg viewPort="0 0 24 24" version="1.1" role="img" xmlns="http://www.w3.org/2000/svg" width="24" height="24"> <title>Hide chat window</title> <line x1="4" y1="20" x2="20" y2="4" stroke-width="2" /> <line x1="4" y1="4" x2="20" y2="20" stroke-width="2" /> </svg> </button> </div> <div class="chat-strapline"> <p> Your AI Powered Scientific Assistant </p> </div> </header> <div class="chat-message-container">   <div class="bot-message default-message"> <div class="bot-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 144.23 169.55" focusable="false" role="img"> <defs></defs> <g> <path class="azthena-color-3" d="m23.48,49c-9.76,9.76-15.8,23.24-15.8,38.13,0,29.77,24.14,53.91,53.91,53.91,14.89,0,28.37-6.04,38.13-15.79-39.85-4.79-71.45-36.39-76.24-76.24Z"></path> <path class="azthena-color-1" d="m141.6,101.53c3.87-14.41,7.12-50.5-18.4-76.02C89.18-8.51,34.02-8.51,0,25.52l23.48,23.48c9.76-9.76,23.23-15.79,38.12-15.79,29.77,0,53.91,24.14,53.91,53.91,0,14.89-6.03,28.37-15.79,38.12l20.52,20.52,23.79,23.79s-14.44-23.33-2.43-68.02Z"></path> </g> </svg> </div> <div class="bot-message-content"> <p>Hi, I'm Azthena, you can trust me to find commercial scientific answers from News-Medical.net.</p> <div class="azthena-login-message"> <p>To start a conversation, please log into your AZoProfile account first, or create a new account.</p> <p>Registered members can chat with Azthena, request quotations, download pdf's, brochures and subscribe to our related <a id="ctl00_acChat_hypNewsletterContentLink" href="/medical/newsletters" target="_blank">newsletter content</a>.</p> <div class="azthena-button-container"> <button type="button" class="azthena-button azthena-login-button" aria-label="Login">Log in</button> </div> </div> </div> </div>  <div class="bot-message terms-details"> <div class="bot-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 144.23 169.55" focusable="false" role="img"> <defs></defs> <g> <path class="azthena-color-3" d="m23.48,49c-9.76,9.76-15.8,23.24-15.8,38.13,0,29.77,24.14,53.91,53.91,53.91,14.89,0,28.37-6.04,38.13-15.79-39.85-4.79-71.45-36.39-76.24-76.24Z"></path> <path class="azthena-color-1" d="m141.6,101.53c3.87-14.41,7.12-50.5-18.4-76.02C89.18-8.51,34.02-8.51,0,25.52l23.48,23.48c9.76-9.76,23.23-15.79,38.12-15.79,29.77,0,53.91,24.14,53.91,53.91,0,14.89-6.03,28.37-15.79,38.12l20.52,20.52,23.79,23.79s-14.44-23.33-2.43-68.02Z"></path> </g> </svg> </div> <div class="bot-message-content"> <p>A few things you need to know before we start. <b>Please read and <u>accept</u> to continue.</b></p> <ul> <li> Use of “Azthena” is subject to the terms and conditions of use as set out by <a href="https://openai.com/policies/terms-of-use" target="_blank" rel="nofollow noopener">OpenAI</a>. </li> <li> Content provided on any AZoNetwork sites are subject to the site <a href="/medical/terms" target="_blank">Terms & Conditions</a> and <a href="/medical/privacy" target="_blank">Privacy Policy</a>. </li> <li> Large Language Models can make mistakes. Consider checking important information. </li> </ul> <div class="agree-azthena-container"> <input type="checkbox" id="agree-azthena-tips" title="Required to continue" /><label for="agree-azthena-tips" class="agree-azthena-text">I understand, and agree to receive occasional emails about Azthena such as usage tips and new feature announcements.</label> <p class="azthena-agree-tips-warning">Please check the box above to proceed.</p> </div> <div class="azthena-button-container"> <button type="button" class="azthena-button accept-terms-button" aria-label="Accept Terms">Start Chat</button> </div> </div> </div>  <div class="bot-message terms-accepted terms-pending-acceptance"> <div class="bot-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 144.23 169.55" focusable="false" role="img"> <defs></defs> <g> <path class="azthena-color-3" d="m23.48,49c-9.76,9.76-15.8,23.24-15.8,38.13,0,29.77,24.14,53.91,53.91,53.91,14.89,0,28.37-6.04,38.13-15.79-39.85-4.79-71.45-36.39-76.24-76.24Z"></path> <path class="azthena-color-1" d="m141.6,101.53c3.87-14.41,7.12-50.5-18.4-76.02C89.18-8.51,34.02-8.51,0,25.52l23.48,23.48c9.76-9.76,23.23-15.79,38.12-15.79,29.77,0,53.91,24.14,53.91,53.91,0,14.89-6.03,28.37-15.79,38.12l20.52,20.52,23.79,23.79s-14.44-23.33-2.43-68.02Z"></path> </g> </svg> </div> <div class="bot-message-content"> <p>Great. Ask your question.</p> </div> </div> </div>   <div class="chat-app-footer"> <div class="chat-message-options"> <button type="button" id="clear-chat-button" title="Clear Chat" aria-label="Clear Chat"> <svg focusable="false" role="img"> <title>Clear Chat</title> <use href="/images/trash.svg#icon" /> </svg>Clear Chat </button> <select id="response-types" class="response-types" title="Response Types" name="response-types"> <option value="0">Brief</option> <option value="1">Moderate</option> <option selected value="2">Detailed</option> </select> </div> <div class="chat-inputs"> <textarea class="user-textarea" placeholder="Message..."></textarea> <button type="button" aria-label="Send Message" id="send-message-button" class="chat-action-button"> <svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="currentColor" focusable="false" role="img"> <path d="M17.71,11.29l-5-5a1,1,0,0,0-.33-.21,1,1,0,0,0-.76,0,1,1,0,0,0-.33.21l-5,5a1,1,0,0,0,1.42,1.42L11,9.41V17a1,1,0,0,0,2,0V9.41l3.29,3.3a1,1,0,0,0,1.42,0A1,1,0,0,0,17.71,11.29Z"></path></svg> </button> <button type="button" aria-label="Cancel response" id="stop-response-button" class="chat-action-button"> <svg fill="none" height="20" viewBox="0 0 20 20" width="20" xmlns="http://www.w3.org/2000/svg" focusable="false" role="img"> <path d="M4.5 3C3.67157 3 3 3.67157 3 4.5V15.5C3 16.3284 3.67157 17 4.5 17H15.5C16.3284 17 17 16.3284 17 15.5V4.5C17 3.67157 16.3284 3 15.5 3H4.5Z"/></svg> </button> </div> <div class="input-terms"> <p> Azthena may occasionally provide inaccurate responses.<br /> <a href="#" class="full-terms-link">Read the full terms</a>. </p> </div> </div>  </div>  <div id="full-terms-dialog" class="full-terms-dialog mp-common-dialog mfp-with-anim mfp-hide"> <div class="full-terms-dialog-content"> <p class="modal-terms-dialog-title">Terms</p> <p> While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided. </p> <p> Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles. </p> <p> Please do not ask questions that use sensitive or confidential information. </p> <p>Read the full <a id="modal-terms-dialog-full-terms-link" href="/medical/terms" target="_blank">Terms & Conditions</a>.</p> </div> </div> <div id="chat-response-feedback-dialog" class="chat-response-feedback-dialog mp-common-dialog mfp-with-anim mfp-hide"> <div class="chat-response-feedback-dialog-content"> <p class="modal-response-feedback-title">Provide Feedback</p> <textarea rows="5" placeholder="Please provide details here. To help protect your privacy don't include any personal information." class="modal-textarea chat-response-feedback-textarea"></textarea> <div class="modal-buttons"> <button type="button" aria-label="Submit feedback" class="modal-button response-feedback-submit-button">Submit</button> <button type="button" aria-label="Cancel submitting feedback" class="modal-button response-feedback-cancel-button">Cancel</button> </div> </div> </div> <script type="text/javascript"> //<![CDATA[ $(function() { var regTags = [ 'Apoptosis','Blood','Blood Sugar','Cancer','Cell','Cell Biology','Cell Death','Cell Metabolism','Chemotherapy','Diagnostic','DNA','Drugs','Exhaustion','Genes','Genetic','Glucose','Laboratory','Medicine','Metabolism','Mitochondria','Nucleotide','Nucleotides','Pathology','Pyrimidine','Research','RNA','Tumor' ]; for (var i = 0; i < regTags.length; i++) { Azom.pushAnalyticsEvent('news_tag_pageview', { event_label: regTags[i] }); } Azom.pushAnalyticsEvent(Encoder.htmlDecode('news_source_pageview'), { event_label: Encoder.htmlDecode('eurekalert.org') }); }); //]]> </script> </form> </div> <div id="right-block" class="side-block"> </div> </div> </div> </div> <script type="text/javascript"> //<![CDATA[ var pageImpressionData = { pk: 1, ct: 3, cntid: 796766, catid: '', tid: 0 }; //]]> </script> <script type="text/javascript"> //<![CDATA[ var contentViewData = { type: 'News', id: 796766 }; //]]> </script> <script type="text/javascript" src="https://d2jx2rerrg6sh3.cloudfront.net/bundles/js/desktop/base?v=pZ50GDyUSNXD_QFwuAfJnhQuFM7GM1A_ul2ICTMHvz41"></script> <div class='overlay-content-wrapper'>  <div style="position:absolute;visibility:hidden;"> <div id="rfqForm" class="azoForm-dialog azoForm-desktop-container mfp-with-anim"> <div class="rfq-form-dialog-container-contents"></div> </div> </div> <div id="rfqFormMobileContainerOnPage" class="azoForm-mobile-container"></div>  </div> <script type="text/javascript"> //<![CDATA[ var RfqData = { "RfqSideTabCssClass": "requestQuoteGeneric", "Items": [ { "id": "rfq-generic", "elementSelectors": ["a.requestQuoteGeneric"], "itemType": "generic", "itemName": "", "itemId": 0, "formTitle": "Request a Quote or Further Information" } ] } ; $(function() { Azom.initRfqPage(); }); //]]> </script> <div id='suggested-content-slider'> <div class='sgcnt-header'> You might also like... <button type="button" class="sgcnt-close" aria-label="Close"> <span aria-hidden="true">×</span> </button> </div> <div class='sgcnt-content'> <a href="/news/20250224/Physical-activity-could-help-colon-cancer-survivors-match-general-population-survival-rates.aspx" title="Physical activity could help colon cancer survivors match general population survival rates"><img src="https://d2jx2rerrg6sh3.cloudfront.net/image-handler/picture/2017/7/Female_doctor_in_white_uniform_with_royal_dark_navy_blue_ribbon-_BlurryMe_be07541866c04648812135f846b0b05f-80x70.jpg" alt="" />Physical activity could help colon cancer survivors match general population survival rates</a> </div> </div> </body> </html>

CINXE.COM

Study reveals how cancer cells evade chemotherapy in low-glucose environments