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class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Prophylactic_against_cocaine_addiction"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Prophylactic against cocaine addiction</span> </div> </a> <ul id="toc-Prophylactic_against_cocaine_addiction-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Marker_for_risk_of_SIDS" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Marker_for_risk_of_SIDS"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>Marker for risk of SIDS</span> </div> </a> <ul id="toc-Marker_for_risk_of_SIDS-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Interactive_pathway_map" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactive_pathway_map"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Interactive pathway map</span> </div> </a> <ul id="toc-Interactive_pathway_map-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Inhibitors" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Inhibitors"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Inhibitors</span> </div> </a> <ul id="toc-Inhibitors-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Nomenclature" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Nomenclature"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Nomenclature</span> </div> </a> <ul id="toc-Nomenclature-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>External links</span> </div> 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Available in 17 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-17" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">17 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%83%D9%88%D9%84%D9%8A%D9%86_%D8%A7%D8%B3%D8%AA%D8%B1%D8%A7%D8%B2_%D9%83%D8%A7%D8%B0%D8%A8" title="كولين استراز كاذب – Arabic" lang="ar" hreflang="ar" data-title="كولين استراز كاذب" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/BCHE" title="BCHE – Welsh" lang="cy" hreflang="cy" data-title="BCHE" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Pseudocholinesterase" title="Pseudocholinesterase – German" lang="de" hreflang="de" data-title="Pseudocholinesterase" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Pseudocolinesterasa" title="Pseudocolinesterasa – Spanish" lang="es" hreflang="es" data-title="Pseudocolinesterasa" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A8%D9%88%D8%AA%DB%8C%D8%B1%DB%8C%D9%84%E2%80%8C%DA%A9%D9%88%D9%84%DB%8C%D9%86%E2%80%8C%D8%A7%D8%B3%D8%AA%D8%B1%D8%A7%D8%B2" title="بوتیریل‌کولین‌استراز – Persian" lang="fa" hreflang="fa" data-title="بوتیریل‌کولین‌استراز" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Butyrylcholinest%C3%A9rase" title="Butyrylcholinestérase – French" lang="fr" hreflang="fr" data-title="Butyrylcholinestérase" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Butirilcolinesterase" title="Butirilcolinesterase – Galician" lang="gl" hreflang="gl" data-title="Butirilcolinesterase" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Pseudocolinesterasi" title="Pseudocolinesterasi – Italian" lang="it" hreflang="it" data-title="Pseudocolinesterasi" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Butyrylocholinoesteraza" title="Butyrylocholinoesteraza – Polish" lang="pl" hreflang="pl" data-title="Butyrylocholinoesteraza" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Butirilcolinesterase" title="Butirilcolinesterase – Portuguese" lang="pt" hreflang="pt" data-title="Butirilcolinesterase" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Butirilcolinesteraz%C4%83" title="Butirilcolinesterază – Romanian" lang="ro" hreflang="ro" data-title="Butirilcolinesterază" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%91%D1%83%D1%82%D0%B8%D1%80%D0%B8%D0%BB%D1%85%D0%BE%D0%BB%D0%B8%D0%BD%D1%8D%D1%81%D1%82%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="Бутирилхолинэстераза – Russian" lang="ru" hreflang="ru" data-title="Бутирилхолинэстераза" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Butirilholinesteraza" title="Butirilholinesteraza – Serbian" lang="sr" hreflang="sr" data-title="Butirilholinesteraza" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Pseudokoliiniesteraasi" title="Pseudokoliiniesteraasi – Finnish" lang="fi" hreflang="fi" data-title="Pseudokoliiniesteraasi" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/BCHE" title="BCHE – Tatar" lang="tt" hreflang="tt" data-title="BCHE" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%91%D1%83%D1%82%D0%B8%D1%80%D1%96%D0%BB%D1%85%D0%BE%D0%BB%D1%96%D0%BD%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="Бутирілхолінестераза – Ukrainian" lang="uk" hreflang="uk" data-title="Бутирілхолінестераза" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Butyrylcholinesterase" title="Butyrylcholinesterase – Vietnamese" lang="vi" hreflang="vi" data-title="Butyrylcholinesterase" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span 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class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><p class="mw-empty-elt"> </p> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Mammalian protein found in humans</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">BCHE</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_BCHE_PDB_1p0i.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8d/Protein_BCHE_PDB_1p0i.png/250px-Protein_BCHE_PDB_1p0i.png" decoding="async" width="250" height="229" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8d/Protein_BCHE_PDB_1p0i.png/375px-Protein_BCHE_PDB_1p0i.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8d/Protein_BCHE_PDB_1p0i.png/500px-Protein_BCHE_PDB_1p0i.png 2x" data-file-width="988" data-file-height="906" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q03311%20or%20P06276">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q03311,P06276">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1P0P">1P0P</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4AXB">4AXB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4B0P">4B0P</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XQG">2XQG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1XLV">1XLV</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WIK">2WIK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WIL">2WIL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1P0Q">1P0Q</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1XLU">1XLU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4BDS">4BDS</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XQF">2XQF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PM8">2PM8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XQK">2XQK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4AQD">4AQD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4BBZ">4BBZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WID">2WID</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XMB">2XMB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1XLW">1XLW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XMC">2XMC</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4TPK">4TPK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XMG">2XMG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XMD">2XMD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3DKK">3DKK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3O9M">3O9M</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WSL">2WSL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WIJ">2WIJ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1P0I">1P0I</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WIG">2WIG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XQJ">2XQJ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3DJY">3DJY</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1P0M">1P0M</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4B0O">4B0O</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2XQI">2XQI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2Y1K">2Y1K</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4XII">4XII</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2WIF">2WIF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2J4C">2J4C</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/983">BCHE</a></span>, CHE1, CHE2, E1, butyrylcholinesterase, BCHED</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/177400">177400</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:894278">894278</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=20065">20065</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=BCHE">BCHE</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000114200">BCHE - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (human)"><img alt="Chromosome 3 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/300px-Ideogram_human_chromosome_3.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/450px-Ideogram_human_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/600px-Ideogram_human_chromosome_3.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_3_(human)" class="mw-redirect" title="Chromosome 3 (human)">Chromosome 3 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_3_ideogram.svg" class="mw-file-description" title="Chromosome 3 (human)"><img alt="Chromosome 3 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/300px-Human_chromosome_3_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/450px-Human_chromosome_3_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/600px-Human_chromosome_3_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 240.53999632829px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for BCHE"><img alt="Genomic location for BCHE" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 246.5px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for BCHE"><img alt="Genomic location for BCHE" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">3q26.1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">165,772,904 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">165,837,462 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (mouse)"><img alt="Chromosome 3 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/260px-Ideogram_house_mouse_chromosome_3.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/390px-Ideogram_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/520px-Ideogram_house_mouse_chromosome_3.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 3 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (mouse)"><img alt="Chromosome 3 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/300px-Ideogram_of_house_mouse_chromosome_3.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/450px-Ideogram_of_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/600px-Ideogram_of_house_mouse_chromosome_3.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 129.82994712941px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for BCHE"><img alt="Genomic location for BCHE" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 135.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for BCHE"><img alt="Genomic location for BCHE" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">3|3 E3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">73,543,141 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">73,615,748 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000114200">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">parietal pleura</li><br /><li style="line-height: 137%;">right lobe of liver</li><br /><li style="line-height: 137%;">germinal epithelium</li><br /><li style="line-height: 137%;">left uterine tube</li><br /><li style="line-height: 137%;">muscle layer of sigmoid colon</li><br /><li style="line-height: 137%;">pericardium</li><br /><li style="line-height: 137%;">seminal vesicula</li><br /><li style="line-height: 137%;">visceral pleura</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">body of uterus</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000027792">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">left lobe of liver</li><br /><li style="line-height: 137%;">ascending aorta</li><br /><li style="line-height: 137%;">white adipose tissue</li><br /><li style="line-height: 137%;">atrium</li><br /><li style="line-height: 137%;">brown adipose tissue</li><br /><li style="line-height: 137%;">intercostal muscle</li><br /><li style="line-height: 137%;">epithelium of stomach</li><br /><li style="line-height: 137%;">jejunum</li><br /><li style="line-height: 137%;">lumbar spinal ganglion</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000114200">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_BCHE_205433_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/df/PBB_GE_BCHE_205433_at_fs.png/250px-PBB_GE_BCHE_205433_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/df/PBB_GE_BCHE_205433_at_fs.png/375px-PBB_GE_BCHE_205433_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/df/PBB_GE_BCHE_205433_at_fs.png/500px-PBB_GE_BCHE_205433_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/590/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0052689">carboxylic ester hydrolase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001540">amyloid-beta binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004104">cholinesterase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033265">choline binding</a></li> <li><a href="https://www.wikidata.org/wiki/Q1735592" class="extiw" title="d:Q1735592">catalytic activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003990">acetylcholinesterase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019899">enzyme binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016787">hydrolase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016788">hydrolase activity, acting on ester bonds</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005788">endoplasmic reticulum lumen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072562">blood microparticle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005783">endoplasmic reticulum</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005641">nuclear envelope lumen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019695">choline metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007584">response to nutrient</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014016">neuroblast differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051384">response to glucocorticoid</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050805">negative regulation of synaptic transmission</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007612">learning</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050783">cocaine metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043279">response to alkaloid</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051593">response to folic acid</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008285">negative regulation of cell population proliferation</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=590&rn=1">590</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=12038&rn=1">12038</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000114200;db=core">ENSG00000114200</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000027792;db=core">ENSMUSG00000027792</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P06276">P06276</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q03311">Q03311</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000055">NM_000055</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009738">NM_009738</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000046">NP_000046</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_033868">NP_033868</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr3:165772904-165837462">Chr 3: 165.77 – 165.84 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr3:73543141-73615748">Chr 3: 73.54 – 73.62 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14913510" class="extiw" title="d:Q14913510">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14913511" class="extiw" title="d:Q14913511">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Butyrylcholinesterase</b> (<a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a> symbol <b>BCHE</b>; EC 3.1.1.8), <a href="#Nomenclature">also known as</a> <b>BChE</b>, <b>BuChE</b>, <b>BuChase</b>, <b>pseudocholinesterase</b>, or <b>plasma (cholin)esterase</b>,<sup id="cite_ref-umm_serum_5-0" class="reference"><a href="#cite_note-umm_serum-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> is a nonspecific <a href="/wiki/Cholinesterase" title="Cholinesterase">cholinesterase</a> enzyme that hydrolyses many different <a href="/wiki/Choline" title="Choline">choline</a>-based <a href="/wiki/Ester" title="Ester">esters</a>. In humans, it is made in the liver, found mainly in <a href="/wiki/Blood_plasma" title="Blood plasma">blood plasma</a>, and encoded by the <i>BCHE</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid1769657_6-0" class="reference"><a href="#cite_note-pmid1769657-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>It is very similar to the neuronal <a href="/wiki/Acetylcholinesterase" title="Acetylcholinesterase">acetylcholinesterase</a>, which is also known as RBC or erythrocyte cholinesterase.<sup id="cite_ref-umm_serum_5-1" class="reference"><a href="#cite_note-umm_serum-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The term "serum cholinesterase" is generally used in reference to a clinical test that reflects levels of both of these enzymes in the blood.<sup id="cite_ref-umm_serum_5-2" class="reference"><a href="#cite_note-umm_serum-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Assay of butyrylcholinesterase activity in plasma can be used as a <a href="/wiki/Liver_function_test" class="mw-redirect" title="Liver function test">liver function test</a> as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. The half-life of BCHE is approximately 10 to 14 days.<sup id="cite_ref-pmid6992635_7-0" class="reference"><a href="#cite_note-pmid6992635-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Butyrylcholine" title="Butyrylcholine">Butyrylcholine</a> is a synthetic compound that does not occur in the body naturally. It is used as a tool to distinguish between acetylcholinesterase and butyrylcholinesterase. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Potential_physiological_role">Potential physiological role</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=1" title="Edit section: Potential physiological role"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Butyrylcholinesterase may be a physiological ghrelin regulator.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=2" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Pseudocholinesterase_deficiency" title="Pseudocholinesterase deficiency">Pseudocholinesterase deficiency</a> results in delayed metabolism of only a few compounds of clinical significance, including the following: <a href="/wiki/Succinylcholine" class="mw-redirect" title="Succinylcholine">succinylcholine</a>, <a href="/wiki/Mivacurium" class="mw-redirect" title="Mivacurium">mivacurium</a>, <a href="/wiki/Procaine" title="Procaine">procaine</a>, <a href="/wiki/Heroin" title="Heroin">heroin</a>, and <a href="/wiki/Cocaine" title="Cocaine">cocaine</a>. Of these, its most clinically important substrate is the depolarizing neuromuscular blocking agent, <a href="/wiki/Succinylcholine" class="mw-redirect" title="Succinylcholine">succinylcholine</a>, which the pseudocholinesterase enzyme hydrolyzes to succinylmonocholine and then to succinic acid.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (May 2024)">citation needed</span></a></i>]</sup> </p><p>In individuals with normal plasma levels of normally functioning pseudocholinesterase enzyme, hydrolysis and inactivation of approximately 90–95% of an intravenous dose of succinylcholine occurs before it reaches the neuromuscular junction. The remaining 5–10% of the succinylcholine dose acts as an acetylcholine receptor agonist at the neuromuscular junction, causing prolonged depolarization of the postsynaptic junction of the motor-end plate. This depolarization initially triggers <a href="/wiki/Fasciculation" title="Fasciculation">fasciculation</a> of skeletal muscle. As a result of prolonged depolarization, endogenous acetylcholine released from the presynaptic membrane of the motor neuron does not produce any additional change in membrane potential after binding to its receptor on the myocyte. Flaccid paralysis of skeletal muscles develops within one minute. In normal subjects, skeletal muscle function returns to normal approximately five minutes after a single bolus injection of succinylcholine as it passively diffuses away from the neuromuscular junction. Pseudocholinesterase deficiency can result in higher levels of intact succinylcholine molecules reaching receptors in the neuromuscular junction, causing the duration of paralytic effect to continue for as long as eight hours. This condition is recognized clinically when paralysis of the respiratory and other skeletal muscles fails to spontaneously resolve after succinylcholine is administered as an adjunctive paralytic agent during anesthesia procedures. In such cases respiratory assistance is required.<sup id="cite_ref-urlPseudocholinesterase_Deficiency_9-0" class="reference"><a href="#cite_note-urlPseudocholinesterase_Deficiency-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Mutant alleles at the BCHE locus are responsible for <a href="/wiki/Suxamethonium" class="mw-redirect" title="Suxamethonium">suxamethonium</a> sensitivity. Homozygous persons sustain prolonged <a href="/wiki/Apnea" title="Apnea">apnea</a> after administration of the muscle relaxant suxamethonium in connection with surgical <a href="/wiki/Anesthesia" title="Anesthesia">anesthesia</a>. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the <a href="/wiki/Homozygote" class="mw-redirect" title="Homozygote">homozygote</a> is at no known disadvantage.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Finally, pseudocholinesterase metabolism of <a href="/wiki/Procaine" title="Procaine">procaine</a> results in formation of <a href="/wiki/Paraaminobenzoic_acid" class="mw-redirect" title="Paraaminobenzoic acid">paraaminobenzoic acid</a> (PABA). If the patient receiving procaine is on <a href="/wiki/Sulfonamide_(medicine)" title="Sulfonamide (medicine)">sulfonamide</a> antibiotics such as <a href="/wiki/Bactrim" class="mw-redirect" title="Bactrim">bactrim</a> the antibiotic effect will be antagonized by providing a new source of PABA to the microbe for subsequent synthesis of <a href="/wiki/Folic_acid" class="mw-redirect" title="Folic acid">folic acid</a>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (May 2024)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="Prophylactic_countermeasure_against_nerve_agents">Prophylactic countermeasure against nerve agents</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=3" title="Edit section: Prophylactic countermeasure against nerve agents"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Butyrylcholinesterase is a <a href="/wiki/Prophylactic" class="mw-redirect" title="Prophylactic">prophylactic</a> <a href="/wiki/Countermeasure" title="Countermeasure">countermeasure</a> against <a href="/wiki/Organophosphate" title="Organophosphate">organophosphate</a> <a href="/wiki/Nerve_agent" title="Nerve agent">nerve agents</a>. It binds nerve agent in the bloodstream before it can exert effects in the nervous system. Because it is a biological scavenger (and universal target), it is currently the only therapeutic agent effective in providing complete <a href="/wiki/Stoichiometry" title="Stoichiometry">stoichiometric</a> protection against the entire spectrum of organophosphate nerve agents.<sup id="cite_ref-urlMedical_Identification_and_Treatment_Systems(MITS)_11-0" class="reference"><a href="#cite_note-urlMedical_Identification_and_Treatment_Systems(MITS)-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Prophylactic_against_cocaine_addiction">Prophylactic against cocaine addiction</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=4" title="Edit section: Prophylactic against cocaine addiction"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>An experimental new drug was developed for the potential treatment of <a href="/wiki/Cocaine" title="Cocaine">cocaine</a> abuse and overdose based on the pseudocholinesterase structure (it was a human BChE mutant with improved catalytic efficiency). It was shown to remove cocaine from the body 2000 times as fast as the natural form of BChE. Studies in rats have shown that the drug prevented <a href="/wiki/Convulsions" class="mw-redirect" title="Convulsions">convulsions</a> and death when administered cocaine overdoses.<sup id="cite_ref-pmid18710224_12-0" class="reference"><a href="#cite_note-pmid18710224-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>Transplantation of skin cells modified to express the enhanced form of butyrylcholinesterase into mice enables the long-term release of the enzyme and efficiently protects the mice from cocaine-seeking behavior and cocaine overdose.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Marker_for_risk_of_SIDS">Marker for risk of SIDS</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=5" title="Edit section: Marker for risk of SIDS"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Research published by the SIDS and Sleep Apnoea Research Group of The Children's Hospital in Westmead, New South Wales, Australia, in the May 6, 2022 edition of in <i><a href="/wiki/The_Lancet" title="The Lancet">The Lancet</a></i> indicates that BChE may be a marker for babies that are at risk of <a href="/wiki/Sudden_infant_death_syndrome" class="mw-redirect" title="Sudden infant death syndrome">sudden infant death syndrome</a> (SIDS). That is, lower levels of BChE were associated with an increased risk of SIDS.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactive_pathway_map">Interactive pathway map</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=6" title="Edit section: Interactive pathway map"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>Click on genes, proteins and metabolites below to link to respective articles.</i> <sup id="cite_ref-WikiPathways_15-0" class="reference"><a href="#cite_note-WikiPathways-15"><span class="cite-bracket">[</span>§ 1<span class="cite-bracket">]</span></a></sup> </p> <div style="overflow:auto;"> <div class="thumb tleft"> <div class="thumbinner" style="width: 377px;"> <div class="thumbimage" style="width: 375px; height: 350px; overflow: hidden;"> <div style="position: relative; top: -25px; left: -186.932773109244px; width: {{{bSize}}}px"><div class="noresize">[[File:<div class="noresize thumb tnone" style=";"> <div class="thumbinner" style="overflow:hidden;width:771px;"> <div class="thumbimage" style="overflow:hidden; position:relative; background-color:white;"> <div style=";left:0px; top:0px; width:769px; position:absolute;"> <figure class="mw-default-size mw-halign-right noresize" typeof="mw:File"><a href="/wiki/Irinotecan#Interactive_pathway_map" title="Go to pathway article"><img alt="IrinotecanPathway_WP46359" src="//upload.wikimedia.org/wikipedia/commons/e/ec/IrinotecanPathway_WP229.png" decoding="async" width="769" height="905" class="mw-file-element" data-file-width="769" data-file-height="905" usemap="#ImageMap_241d8b96c5c6bf82" /></a><map name="ImageMap_241d8b96c5c6bf82"><area href="/wiki/Carboxylesterase_2" shape="rect" coords="374,349,434,369" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="366,307,426,327" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="415,125,475,145" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="136,289,185,309" alt="go to article" title="go to article" /><area href="/wiki/CYP3A5" shape="rect" coords="120,322,171,342" alt="go to article" title="go to article" /><area href="/wiki/Adenomatosis_polyposis_coli" shape="rect" coords="254,223,314,243" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="204,294,264,314" alt="go to article" title="go to article" /><area href="/wiki/CYP3A5" shape="rect" coords="257,331,317,351" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="194,364,254,384" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="251,459,311,479" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="251,479,311,499" alt="go to article" title="go to article" /><area href="/wiki/UGT1A9" shape="rect" coords="531,495,591,515" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="88,579,148,599" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="88,599,148,619" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="327,717,387,737" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="216,702,276,722" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="216,722,276,742" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="352,566,412,586" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="352,586,412,606" alt="go to article" title="go to article" /><area href="/wiki/ABCG2" shape="rect" coords="352,606,412,626" alt="go to article" title="go to article" /><area href="/wiki/UDP_glucuronosyltransferase_1_family,_polypeptide_A1" shape="rect" coords="479,716,528,736" alt="go to article" title="go to article" /><area href="/wiki/UGT1A10" shape="rect" coords="406,716,461,736" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="177,126,226,146" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="247,126,299,146" alt="go to article" title="go to article" /><area href="/wiki/Butyrylcholinesterase" shape="rect" coords="341,126,388,146" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="551,590,611,610" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="484,183,534,203" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="414,404,474,424" alt="go to article" title="go to article" /><area href="/wiki/SLCO1B1" shape="rect" coords="411,181,464,201" alt="go to article" title="go to article" /></map><figcaption></figcaption></figure></div> <div style="text-align:left; background-color:transparent; color:white; line-height:110%;"> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:494.74789915966403px; top:463.949579831933px; background:transparent; border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; 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border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:39.3445378151259px; height:12px; overflow:hidden; position:relative; left:341.2605042016808px; top:113.666666666667px; background:transparent; border:4px black solid"></div>]]</span></div> </div> <div style="visibility:hidden"><figure class="mw-default-size mw-halign-right noresize" typeof="mw:File"><a href="/wiki/Irinotecan#Interactive_pathway_map" title="Go to pathway article"><img alt="IrinotecanPathway_WP46359" src="//upload.wikimedia.org/wikipedia/commons/e/ec/IrinotecanPathway_WP229.png" decoding="async" width="769" height="905" class="mw-file-element" data-file-width="769" data-file-height="905" usemap="#ImageMap_241d8b96c5c6bf82" /></a><map name="ImageMap_241d8b96c5c6bf82"><area href="/wiki/Carboxylesterase_2" shape="rect" coords="374,349,434,369" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="366,307,426,327" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="415,125,475,145" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="136,289,185,309" alt="go to article" title="go to article" /><area href="/wiki/CYP3A5" shape="rect" coords="120,322,171,342" alt="go to article" title="go to article" /><area href="/wiki/Adenomatosis_polyposis_coli" shape="rect" coords="254,223,314,243" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="204,294,264,314" alt="go to article" title="go to article" /><area href="/wiki/CYP3A5" shape="rect" coords="257,331,317,351" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="194,364,254,384" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="251,459,311,479" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="251,479,311,499" alt="go to article" title="go to article" /><area href="/wiki/UGT1A9" shape="rect" coords="531,495,591,515" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="88,579,148,599" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="88,599,148,619" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="327,717,387,737" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="216,702,276,722" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="216,722,276,742" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="352,566,412,586" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="352,586,412,606" alt="go to article" title="go to article" /><area href="/wiki/ABCG2" shape="rect" coords="352,606,412,626" alt="go to article" title="go to article" /><area href="/wiki/UDP_glucuronosyltransferase_1_family,_polypeptide_A1" shape="rect" coords="479,716,528,736" alt="go to article" title="go to article" /><area href="/wiki/UGT1A10" shape="rect" coords="406,716,461,736" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="177,126,226,146" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="247,126,299,146" alt="go to article" title="go to article" /><area href="/wiki/Butyrylcholinesterase" shape="rect" coords="341,126,388,146" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="551,590,611,610" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="484,183,534,203" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="414,404,474,424" alt="go to article" title="go to article" /><area href="/wiki/SLCO1B1" shape="rect" coords="411,181,464,201" alt="go to article" title="go to article" /></map><figcaption></figcaption></figure></div> </div> <div class="thumbcaption"></div> </div></div>|alt=Irinotecan Pathway <a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP46359">edit</a>]]</div></div> </div> <div class="thumbcaption"> <div class="magnify"><a href="/wiki/File:IrinotecanPathway_WP229.png" title="File:IrinotecanPathway WP229.png"> </a></div>Irinotecan Pathway <a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP46359">edit</a> </div> </div> </div> <div style="clear:both;" class=""></div><style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-WikiPathways-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-WikiPathways_15-0">^</a></b></span> <span class="reference-text">The interactive pathway map can be edited at WikiPathways: <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP229">"IrinotecanPathway_WP229"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=IrinotecanPathway_WP229&rft_id=http%3A%2F%2Fwww.wikipathways.org%2Findex.php%2FPathway%3AWP229&rfr_id=info%3Asid%2Fen.wikipedia.org%3AButyrylcholinesterase" class="Z3988"></span></span> </li> </ol></div></div> </div> <div class="mw-heading mw-heading2"><h2 id="Inhibitors">Inhibitors</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=7" title="Edit section: Inhibitors"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Cholinesterase_inhibitor" title="Cholinesterase inhibitor">Cholinesterase inhibitor</a></div> <ul><li><a href="/wiki/Cannabinoid" title="Cannabinoid">Phytocannabinoids</a><sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> <ul><li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li>Δ8-<a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">tetrahydrocannabinol</a></li> <li><a href="/wiki/Cannabigerol" title="Cannabigerol">Cannabigerol</a></li> <li><a href="/wiki/Cannabigerolic_acid" title="Cannabigerolic acid">Cannabigerolic</a> acid</li> <li><a href="/wiki/Cannabicitran" title="Cannabicitran">Cannabicitran</a></li> <li><a href="/wiki/Cannabidivarin" title="Cannabidivarin">Cannabidivarin</a></li> <li><a href="/wiki/Cannabichromene" title="Cannabichromene">Cannabichromene</a></li> <li><a href="/wiki/Cannabinol" title="Cannabinol">Cannabinol</a></li></ul></li> <li><a href="/wiki/Cymserine" title="Cymserine">Cymserine</a> and derivatives</li> <li><a href="/wiki/Profenamine" title="Profenamine">Profenamine</a></li> <li><a href="/wiki/Rivastigmine" title="Rivastigmine">Rivastigmine</a></li> <li><a href="/wiki/Tacrine" title="Tacrine">Tacrine</a></li> <li>(+)-ZINC-12613047: IC<sub>50</sub> human BChE 13nM, high selectivity over <a href="/wiki/AChE" class="mw-redirect" title="AChE">AChE</a>.<sup id="cite_ref-pmid25226236_17-0" class="reference"><a href="#cite_note-pmid25226236-17"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup></li> <li>Hybrid/bitopic ligands<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Nomenclature">Nomenclature</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=8" title="Edit section: Nomenclature"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The nomenclatural variations of BCHE and of cholinesterases generally are discussed at <i><a href="/wiki/Cholinesterase#Types_and_nomenclature" title="Cholinesterase">Cholinesterase § Types and nomenclature</a></i>. </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=9" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterases</a></li> <li><a href="/wiki/Dibucaine_number" title="Dibucaine number">Dibucaine number</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=10" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link 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"The effects of indole-3-acetic acid on human and horse serum butyrylcholinesterase". <i>Chemico-Biological Interactions</i>. 157–158 (16): 375–378. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cbi.2005.10.061">10.1016/j.cbi.2005.10.061</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16429500">16429500</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Chemico-Biological+Interactions&rft.atitle=The+effects+of+indole-3-acetic+acid+on+human+and+horse+serum+butyrylcholinesterase&rft.volume=157-158&rft.issue=16&rft.pages=375-378&rft.date=2005-12&rft_id=info%3Adoi%2F10.1016%2Fj.cbi.2005.10.061&rft_id=info%3Apmid%2F16429500&rft.aulast=Bodur&rft.aufirst=E&rft.au=Cokugras%2C+AN&rfr_id=info%3Asid%2Fen.wikipedia.org%3AButyrylcholinesterase" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLockridge1988" class="citation journal cs1">Lockridge O (October 1988). 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"Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin". <i>Cellular and Molecular Neurobiology</i>. <b>21</b> (3): 285–296. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1023%2FA%3A1010947205224">10.1023/A:1010947205224</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11569538">11569538</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9861675">9861675</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Neurobiology&rft.atitle=Butyrylcholinesterase-Mediated+enhancement+of+the+enzymatic+activity+of+trypsin&rft.volume=21&rft.issue=3&rft.pages=285-296&rft.date=2001-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A9861675%23id-name%3DS2CID&rft_id=info%3Apmid%2F11569538&rft_id=info%3Adoi%2F10.1023%2FA%3A1010947205224&rft.aulast=Darvesh&rft.aufirst=S&rft.au=Kumar%2C+R&rft.au=Roberts%2C+S&rft.au=Walsh%2C+R&rft.au=Martin%2C+E&rfr_id=info%3Asid%2Fen.wikipedia.org%3AButyrylcholinesterase" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBartaSasvari-SzekelyDevaiKovacs2001" class="citation journal cs1">Barta C, Sasvari-Szekely M, Devai A, Kovacs E, Staub M, Enyedi P (December 2001). "Analysis of mutations in the plasma cholinesterase gene of patients with a history of prolonged neuromuscular block during anesthesia". <i>Molecular Genetics and Metabolism</i>. <b>74</b> (4): 484–488. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fmgme.2001.3251">10.1006/mgme.2001.3251</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11749053">11749053</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Genetics+and+Metabolism&rft.atitle=Analysis+of+mutations+in+the+plasma+cholinesterase+gene+of+patients+with+a+history+of+prolonged+neuromuscular+block+during+anesthesia&rft.volume=74&rft.issue=4&rft.pages=484-488&rft.date=2001-12&rft_id=info%3Adoi%2F10.1006%2Fmgme.2001.3251&rft_id=info%3Apmid%2F11749053&rft.aulast=Barta&rft.aufirst=C&rft.au=Sasvari-Szekely%2C+M&rft.au=Devai%2C+A&rft.au=Kovacs%2C+E&rft.au=Staub%2C+M&rft.au=Enyedi%2C+P&rfr_id=info%3Asid%2Fen.wikipedia.org%3AButyrylcholinesterase" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Butyrylcholinesterase&action=edit&section=12" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Butyrylcholinesterase">Butyrylcholinesterase</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=BCHE"><i>BCHE</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=BCHE"><i>BCHE</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist 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structure of human butyryl cholinesterase" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/PDB_1p0i_EBI.jpg/180px-PDB_1p0i_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/PDB_1p0i_EBI.jpg/270px-PDB_1p0i_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/PDB_1p0i_EBI.jpg/360px-PDB_1p0i_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1p0i</b>: Crystal structure of human butyryl cholinesterase</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1p0m_EBI.jpg" class="mw-file-description" title="1p0m: Crystal structure of human butyryl cholinesterase in complex with a choline molecule"><img alt="1p0m: Crystal structure of human butyryl cholinesterase in complex with a choline molecule" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_1p0m_EBI.jpg/180px-PDB_1p0m_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_1p0m_EBI.jpg/270px-PDB_1p0m_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5e/PDB_1p0m_EBI.jpg/360px-PDB_1p0m_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1p0m</b>: Crystal structure of human butyryl cholinesterase in complex with a choline molecule</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1p0p_EBI.jpg" class="mw-file-description" title="1p0p: Crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine"><img alt="1p0p: Crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/34/PDB_1p0p_EBI.jpg/180px-PDB_1p0p_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/34/PDB_1p0p_EBI.jpg/270px-PDB_1p0p_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/34/PDB_1p0p_EBI.jpg/360px-PDB_1p0p_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1p0p</b>: Crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1p0q_EBI.jpg" class="mw-file-description" title="1p0q: Crystal structure of soman-aged human butyryl cholinesterase"><img alt="1p0q: Crystal structure of soman-aged human butyryl cholinesterase" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/PDB_1p0q_EBI.jpg/180px-PDB_1p0q_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/PDB_1p0q_EBI.jpg/270px-PDB_1p0q_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1d/PDB_1p0q_EBI.jpg/360px-PDB_1p0q_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1p0q</b>: Crystal structure of soman-aged human butyryl cholinesterase</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1xlu_EBI.jpg" class="mw-file-description" title="1xlu: X-Ray Structure Of Di-Isopropyl-Phosphoro-Fluoridate (Dfp) Inhibited Butyrylcholinesterase after Aging"><img alt="1xlu: X-Ray Structure Of Di-Isopropyl-Phosphoro-Fluoridate (Dfp) Inhibited Butyrylcholinesterase after Aging" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1xlu_EBI.jpg/180px-PDB_1xlu_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1xlu_EBI.jpg/270px-PDB_1xlu_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1xlu_EBI.jpg/360px-PDB_1xlu_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1xlu</b>: X-Ray Structure Of Di-Isopropyl-Phosphoro-Fluoridate (Dfp) Inhibited Butyrylcholinesterase after Aging</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1xlv_EBI.jpg" class="mw-file-description" title="1xlv: Ethylphosphorylated Butyrylcholinesterase (Aged) Obtained By Reaction With Echothiophate"><img alt="1xlv: Ethylphosphorylated Butyrylcholinesterase (Aged) Obtained By Reaction With Echothiophate" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c2/PDB_1xlv_EBI.jpg/180px-PDB_1xlv_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c2/PDB_1xlv_EBI.jpg/270px-PDB_1xlv_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c2/PDB_1xlv_EBI.jpg/360px-PDB_1xlv_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1xlv</b>: Ethylphosphorylated Butyrylcholinesterase (Aged) Obtained By Reaction With Echothiophate</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1xlw_EBI.jpg" class="mw-file-description" title="1xlw: Diethylphosphorylated Butyrylcholinesterase (Nonaged) Obtained By Reaction With Echothiophate"><img alt="1xlw: Diethylphosphorylated Butyrylcholinesterase (Nonaged) Obtained By Reaction With Echothiophate" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f6/PDB_1xlw_EBI.jpg/180px-PDB_1xlw_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f6/PDB_1xlw_EBI.jpg/270px-PDB_1xlw_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f6/PDB_1xlw_EBI.jpg/360px-PDB_1xlw_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1xlw</b>: Diethylphosphorylated Butyrylcholinesterase (Nonaged) Obtained By Reaction With Echothiophate</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2j4c_EBI.png" class="mw-file-description" title="2j4c: STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH 10MM HGCL2"><img alt="2j4c: STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH 10MM HGCL2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/dc/PDB_2j4c_EBI.png/180px-PDB_2j4c_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/dc/PDB_2j4c_EBI.png/270px-PDB_2j4c_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/dc/PDB_2j4c_EBI.png/360px-PDB_2j4c_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2j4c</b>: STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH 10MM HGCL2</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Hydrolase:_esterases_(EC_3.1)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Esterases" title="Template:Esterases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Esterases" title="Template talk:Esterases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Esterases" title="Special:EditPage/Template:Esterases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Hydrolase:_esterases_(EC_3.1)" style="font-size:114%;margin:0 4em"><a href="/wiki/Hydrolase" title="Hydrolase">Hydrolase</a>: <a href="/wiki/Esterase" title="Esterase">esterases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 3.1)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.1:_Carboxylic_Ester_Hydrolases" title="List of EC numbers (EC 3)">3.1.1</a>: <a href="/wiki/Carboxylic_acid" title="Carboxylic acid">Carboxylic</a><br />ester hydrolases</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterase</a> <ul><li><a href="/wiki/Acetylcholinesterase" title="Acetylcholinesterase">Acetylcholinesterase</a></li> <li><a class="mw-selflink selflink">Butyrylcholinesterase</a></li></ul></li> <li><a href="/wiki/Pectinesterase" title="Pectinesterase">Pectinesterase</a></li> <li><a href="/wiki/6-phosphogluconolactonase" title="6-phosphogluconolactonase">6-phosphogluconolactonase</a></li> <li><a href="/wiki/PAF_acetylhydrolase" class="mw-redirect" title="PAF acetylhydrolase">PAF acetylhydrolase</a></li></ul> <ul><li><a href="/wiki/Lipase" title="Lipase">Lipase</a> <ul><li><a href="/wiki/Bile_salt-dependent_lipase" title="Bile salt-dependent lipase">Bile salt-dependent</a></li> <li><a href="/wiki/Gastric_lipase" title="Gastric lipase">Gastric</a>/<a href="/wiki/Lingual_lipase" title="Lingual lipase">Lingual</a></li> <li><a href="/wiki/Pancreatic_lipase" class="mw-redirect" title="Pancreatic lipase">Pancreatic</a></li> <li><a href="/wiki/Lysosomal_lipase" title="Lysosomal lipase">Lysosomal</a></li> <li><a href="/wiki/Hormone-sensitive_lipase" title="Hormone-sensitive lipase">Hormone-sensitive</a></li> <li><a href="/wiki/Endothelial_lipase" title="Endothelial lipase">Endothelial</a></li> <li><a href="/wiki/Hepatic_lipase" title="Hepatic lipase">Hepatic</a></li> <li><a href="/wiki/Lipoprotein_lipase" title="Lipoprotein lipase">Lipoprotein</a></li> <li><a href="/wiki/Monoacylglycerol_lipase" title="Monoacylglycerol lipase">Monoacylglycerol</a></li> <li><a href="/wiki/Diacylglycerol_lipase" title="Diacylglycerol lipase">Diacylglycerol</a></li></ul></li></ul> <ul><li><a href="/wiki/Phospholipase" title="Phospholipase">Phospholipase</a> <ul><li><a href="/wiki/Phospholipase_A1" title="Phospholipase A1">A1</a></li> <li><a href="/wiki/Phospholipase_A2" title="Phospholipase A2">A2</a></li> <li><a href="/wiki/Phospholipase_B" title="Phospholipase B">B</a></li></ul></li></ul> <ul><li><a href="/wiki/Cutinase" title="Cutinase">Cutinase</a></li> <li><a href="/wiki/PETase" title="PETase">PETase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.2:_Thioester_Hydrolases" title="List of EC numbers (EC 3)">3.1.2</a>: <a href="/wiki/Thioesterase" title="Thioesterase">Thioesterase</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Palmitoyl_protein_thioesterase" class="mw-redirect" title="Palmitoyl protein thioesterase">Palmitoyl protein thioesterase</a></li> <li><a href="/wiki/Ubiquitin_carboxy-terminal_hydrolase_L1" title="Ubiquitin carboxy-terminal hydrolase L1">Ubiquitin carboxy-terminal hydrolase L1</a></li> <li><a href="/wiki/4-hydroxybenzoyl-CoA_thioesterase" title="4-hydroxybenzoyl-CoA thioesterase">4-hydroxybenzoyl-CoA thioesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.3:_Phosphoric_Monoester_Hydrolases" title="List of EC numbers (EC 3)">3.1.3</a>: <a href="/wiki/Phosphatase" title="Phosphatase">Phosphatase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alkaline_phosphatase" title="Alkaline phosphatase">Alkaline phosphatase</a> <ul><li><a href="/wiki/ALPI" title="ALPI">ALPI</a></li> <li><a href="/wiki/ALPL" title="ALPL">ALPL</a></li> <li><a href="/wiki/Placental_alkaline_phosphatase" class="mw-redirect" title="Placental alkaline phosphatase">ALPP</a></li></ul></li> <li><a href="/wiki/Acid_phosphatase" title="Acid phosphatase">Acid phosphatase</a> (<a href="/wiki/Prostatic_acid_phosphatase" title="Prostatic acid phosphatase">Prostatic</a>)/<a href="/wiki/Tartrate-resistant_acid_phosphatase" title="Tartrate-resistant acid phosphatase">Tartrate-resistant acid phosphatase</a>/<a href="/wiki/Purple_acid_phosphatases" title="Purple acid phosphatases">Purple acid phosphatases</a></li> <li><a href="/wiki/Nucleotidase" title="Nucleotidase">Nucleotidase</a></li> <li><a href="/wiki/Glucose_6-phosphatase" title="Glucose 6-phosphatase">Glucose 6-phosphatase</a></li> <li><a href="/wiki/Fructose_1,6-bisphosphatase" title="Fructose 1,6-bisphosphatase">Fructose 1,6-bisphosphatase</a> <ul><li><a href="/wiki/Calcineurin" title="Calcineurin">Calcineurin</a></li></ul></li> <li><a href="/wiki/Protein_phosphatase" title="Protein phosphatase">Protein phosphatase</a> <ul><li><a href="/wiki/PP2A" class="mw-redirect" title="PP2A">PP2A</a></li></ul></li> <li><a href="/wiki/OCRL" title="OCRL">OCRL</a></li> <li><a href="/wiki/Pyruvate_dehydrogenase_phosphatase" title="Pyruvate dehydrogenase phosphatase">Pyruvate dehydrogenase phosphatase</a></li> <li><a href="/wiki/Phosphofructokinase_2" title="Phosphofructokinase 2">Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase</a></li> <li><a href="/wiki/PTEN_(gene)" title="PTEN (gene)">PTEN</a></li> <li><a href="/wiki/Phytase" title="Phytase">Phytase</a> <ul><li><a href="/wiki/Beta-propeller_phytase" title="Beta-propeller phytase">Beta-propeller phytase</a></li></ul></li> <li><a href="/wiki/Inositol-phosphate_phosphatase" title="Inositol-phosphate phosphatase">Inositol-phosphate phosphatase</a> <ul><li><a href="/wiki/Inositol_monophosphatase_1" title="Inositol monophosphatase 1">IMPA1</a>, <a href="/wiki/Inositol_monophosphatase_2" title="Inositol monophosphatase 2">IMPA2</a>, <a href="/wiki/Inositol_monophosphatase_3" title="Inositol monophosphatase 3">IMPA3</a></li></ul></li> <li><a href="/wiki/Protein_phosphatase" title="Protein phosphatase">Protein phosphatase</a>: <a href="/wiki/Protein_tyrosine_phosphatase" title="Protein tyrosine phosphatase">Protein tyrosine phosphatase</a></li> <li><a href="/wiki/Protein_serine/threonine_phosphatase" title="Protein serine/threonine phosphatase">Protein serine/threonine phosphatase</a></li> <li><a href="/wiki/Dual-specificity_phosphatase" title="Dual-specificity phosphatase">Dual-specificity phosphatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.4:_Phosphoric_Diester_Hydrolases" title="List of EC numbers (EC 3)">3.1.4</a>:<br /><a href="/wiki/Phosphodiesterase" title="Phosphodiesterase">Phosphodiesterase</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autotaxin" title="Autotaxin">Autotaxin</a></li> <li><a href="/wiki/Phospholipase" title="Phospholipase">Phospholipase</a> <ul><li><a href="/wiki/Phospholipase_C" title="Phospholipase C">C</a></li> <li><a href="/wiki/Phospholipase_D" title="Phospholipase D">D</a></li></ul></li> <li><a href="/wiki/Sphingomyelin_phosphodiesterase" title="Sphingomyelin phosphodiesterase">Sphingomyelin phosphodiesterase</a> <ul><li><a href="/wiki/Sphingomyelin_phosphodiesterase_1" title="Sphingomyelin phosphodiesterase 1">1</a></li></ul></li> <li><a href="/wiki/PDE1" title="PDE1">PDE1</a></li> <li><a href="/wiki/Phosphodiesterase_2" title="Phosphodiesterase 2">PDE2</a></li> <li><a href="/wiki/Phosphodiesterase_3" title="Phosphodiesterase 3">PDE3</a></li> <li><a href="/wiki/PDE4A" title="PDE4A">PDE4A</a>/<a href="/wiki/PDE4B" title="PDE4B">PDE4B</a></li> <li><a href="/wiki/CGMP-specific_phosphodiesterase_type_5" title="CGMP-specific phosphodiesterase type 5">PDE5</a></li> <li><a href="/wiki/Lecithinase" title="Lecithinase">Lecithinase</a> (<a href="/wiki/Clostridium_perfringens_alpha_toxin" title="Clostridium perfringens alpha toxin">Clostridium perfringens alpha toxin</a>)</li> <li><a href="/wiki/Cyclic_nucleotide_phosphodiesterase" title="Cyclic nucleotide phosphodiesterase">Cyclic nucleotide phosphodiesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.6:_Sulfuric_Ester_Hydrolases" title="List of EC numbers (EC 3)">3.1.6</a>: <a href="/wiki/Sulfatase" title="Sulfatase">Sulfatase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Arylsulfatase" title="Arylsulfatase">arylsulfatase</a></i> <ul><li><a href="/wiki/Arylsulfatase_A" title="Arylsulfatase A">Arylsulfatase A</a></li> <li><a href="/wiki/Arylsulfatase_B" title="Arylsulfatase B">Arylsulfatase B</a></li> <li><a href="/wiki/Arylsulfatase_L" title="Arylsulfatase L">Arylsulfatase L</a></li> <li><a href="/wiki/Steroid_sulfatase" title="Steroid sulfatase">Steroid sulfatase</a></li></ul></li> <li><a href="/wiki/Galactosamine-6_sulfatase" title="Galactosamine-6 sulfatase">Galactosamine-6 sulfatase</a></li> <li><a href="/wiki/Iduronate-2-sulfatase" title="Iduronate-2-sulfatase">Iduronate-2-sulfatase</a></li> <li><a href="/wiki/N-acetylglucosamine-6-sulfatase" title="N-acetylglucosamine-6-sulfatase">N-acetylglucosamine-6-sulfatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nuclease" title="Nuclease">Nuclease</a> (includes<br /><a href="/wiki/Deoxyribonuclease" title="Deoxyribonuclease">deoxyribonuclease</a><br />and <a href="/wiki/Ribonuclease" title="Ribonuclease">ribonuclease</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.11:_Exodeoxyribonucleases_Producing_5.27-Phosphomonoesters" title="List of EC numbers (EC 3)">3.1.11</a>-16:<br /><a href="/wiki/Exonuclease" title="Exonuclease">Exonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Exodeoxyribonuclease" title="Exodeoxyribonuclease">Exodeoxyribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RecBCD" title="RecBCD">RecBCD</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Exoribonuclease" title="Exoribonuclease">Exoribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Oligonucleotidase" title="Oligonucleotidase">Oligonucleotidase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.21:_Endodeoxyribonucleases_Producing_5.27-Phosphomonoesters" title="List of EC numbers (EC 3)">3.1.21</a>-31:<br /><a href="/wiki/Endonuclease" title="Endonuclease">Endonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endodeoxyribonuclease" title="Endodeoxyribonuclease">Endodeoxyribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Deoxyribonuclease_I" title="Deoxyribonuclease I">Deoxyribonuclease I</a></li> <li><a href="/wiki/Deoxyribonuclease_II" title="Deoxyribonuclease II">Deoxyribonuclease II</a></li> <li><a href="/wiki/Deoxyribonuclease_IV" title="Deoxyribonuclease IV">Deoxyribonuclease IV</a></li> <li><a href="/wiki/Restriction_enzyme" title="Restriction enzyme">Restriction enzyme</a>;see <span class="nowrap">{{</span><a href="/wiki/Template:Restriction_enzyme" title="Template:Restriction enzyme">Restriction enzyme</a><span class="nowrap">}}</span></li> <li><a href="/wiki/UvrABC_endonuclease" title="UvrABC endonuclease">UvrABC endonuclease</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endoribonuclease" title="Endoribonuclease">Endoribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RNase_III" class="mw-redirect" title="RNase III">RNase III</a> <ul><li><a href="/wiki/Drosha" title="Drosha">Drosha</a>: <a href="/wiki/Microprocessor_complex" title="Microprocessor complex">Microprocessor complex</a></li> <li><a href="/wiki/Dicer" title="Dicer">Dicer</a>: <a href="/wiki/RNA-induced_silencing_complex" title="RNA-induced silencing complex">RNA-induced silencing complex</a></li></ul></li> <li><a href="/wiki/RNase_H" class="mw-redirect" title="RNase H">RNase H</a> <ul><li><a href="/wiki/RNASEH1" title="RNASEH1">1</a></li> <li><a href="/wiki/RNASEH2A" title="RNASEH2A">2A</a></li> <li><a href="/wiki/RNASEH2B" title="RNASEH2B">2B</a></li> <li><a href="/wiki/RNASEH2C" title="RNASEH2C">2C</a></li></ul></li> <li><a href="/wiki/RNase_P" class="mw-redirect" title="RNase P">RNase P</a></li> <li><a href="/wiki/Ribonuclease_A" class="mw-redirect" title="Ribonuclease A">RNase A</a></li> <li><a href="/wiki/Ribonuclease_Z" title="Ribonuclease Z">RNase Z</a></li> <li><a href="/wiki/Ribonuclease_E" title="Ribonuclease E">RNase E</a> <ul><li><a href="/wiki/RNASE1" title="RNASE1">1</a></li> <li><a href="/wiki/Eosinophil-derived_neurotoxin" title="Eosinophil-derived neurotoxin">2</a></li> <li><a href="/wiki/Eosinophil_cationic_protein" title="Eosinophil cationic protein">3</a></li> <li><a href="/wiki/Angiogenin" title="Angiogenin">4/5</a></li></ul></li> <li><a href="/wiki/Ribonuclease_T1" title="Ribonuclease T1">RNase T1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">either deoxy- or ribo-    </th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclease_S1" title="Nuclease S1">Nuclease S1</a> <ul><li><a href="/wiki/Mung_bean_nuclease" title="Mung bean nuclease">Mung bean nuclease</a></li></ul></li> <li><a href="/wiki/Serratia_marcescens_nuclease" title="Serratia marcescens nuclease">Serratia marcescens nuclease</a></li> <li><a href="/wiki/Micrococcal_nuclease" title="Micrococcal nuclease">Micrococcal nuclease</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes_involved_in_neurotransmission" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Neurotransmitter_metabolism_enzymes" title="Template:Neurotransmitter metabolism enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Neurotransmitter_metabolism_enzymes" title="Template talk:Neurotransmitter metabolism enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Neurotransmitter_metabolism_enzymes" title="Special:EditPage/Template:Neurotransmitter metabolism enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes_involved_in_neurotransmission" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a> involved in <a href="/wiki/Neurotransmitter" title="Neurotransmitter">neurotransmission</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Monoamine_neurotransmitter" title="Monoamine neurotransmitter">monoamine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Histidine" title="Histidine">histidine</a> → <a href="/wiki/Histamine" title="Histamine">histamine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Histidine_decarboxylase" title="Histidine decarboxylase">Histidine decarboxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Histamine_N-methyltransferase" title="Histamine N-methyltransferase">Histamine N-methyltransferase</a></li> <li><a href="/wiki/Diamine_oxidase" title="Diamine oxidase">Diamine oxidase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine" title="Tyrosine">tyrosine</a>→<a href="/wiki/Dopamine" title="Dopamine">dopamine</a>→<a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">epinephrine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosine_hydroxylase" title="Tyrosine hydroxylase">Tyrosine hydroxylase</a></li> <li><a href="/wiki/Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">Aromatic <small>L</small>-amino acid decarboxylase</a></li> <li><a href="/wiki/Dopamine_beta-hydroxylase" title="Dopamine beta-hydroxylase">Dopamine beta-hydroxylase</a></li> <li><a href="/wiki/Phenylethanolamine_N-methyltransferase" title="Phenylethanolamine N-methyltransferase">Phenylethanolamine N-methyltransferase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Catechol-O-methyl_transferase" class="mw-redirect" title="Catechol-O-methyl transferase">Catechol-O-methyl transferase</a></li> <li><a href="/wiki/Monoamine_oxidase" title="Monoamine oxidase">Monoamine oxidase</a> <ul><li><a href="/wiki/Monoamine_oxidase_A" title="Monoamine oxidase A">A</a></li> <li><a href="/wiki/Monoamine_oxidase_B" title="Monoamine oxidase B">B</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Glutamic_acid" title="Glutamic acid">glutamate</a>→<a href="/wiki/Gamma-Aminobutyric_acid" class="mw-redirect" title="Gamma-Aminobutyric acid">GABA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glutamate_decarboxylase" title="Glutamate decarboxylase">Glutamate decarboxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4-aminobutyrate_transaminase" title="4-aminobutyrate transaminase">4-aminobutyrate transaminase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tryptophan" title="Tryptophan">tryptophan</a>→<a href="/wiki/Serotonin" title="Serotonin">serotonin</a>→<a href="/wiki/Melatonin" title="Melatonin">melatonin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tryptophan_hydroxylase" title="Tryptophan hydroxylase">Tryptophan hydroxylase</a></li> <li><a href="/wiki/Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">Aromatic <small>L</small>-amino acid decarboxylase</a></li> <li><a href="/wiki/Aralkylamine_N-acetyltransferase" title="Aralkylamine N-acetyltransferase">Aralkylamine N-acetyltransferase</a></li> <li><a href="/wiki/Acetylserotonin_O-methyltransferase" title="Acetylserotonin O-methyltransferase">Acetylserotonin O-methyltransferase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Arginine" title="Arginine">arginine</a>→<a href="/wiki/Nitric_oxide" title="Nitric oxide">NO</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nitric_oxide_synthase" title="Nitric oxide synthase">Nitric oxide synthase</a> (<a href="/wiki/NOS1" title="NOS1">NOS1</a>, <a href="/wiki/Nitric_oxide_synthase_2_(inducible)" title="Nitric oxide synthase 2 (inducible)">NOS2</a>, <a href="/wiki/Endothelial_NOS" title="Endothelial NOS">NOS3</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Choline" title="Choline">choline</a>→<a href="/wiki/Acetylcholine" title="Acetylcholine">Acetylcholine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Choline_acetyltransferase" title="Choline acetyltransferase">Choline acetyltransferase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterase</a> (<a href="/wiki/Acetylcholinesterase" title="Acetylcholinesterase">Acetylcholinesterase</a>, <a class="mw-selflink selflink">Butyrylcholinesterase</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Acetylcholine_metabolism_and_transport_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Acetylcholine_metabolism_and_transport_modulators" title="Template:Acetylcholine metabolism and transport modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Acetylcholine_metabolism_and_transport_modulators" title="Template talk:Acetylcholine metabolism and transport modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Acetylcholine_metabolism_and_transport_modulators" title="Special:EditPage/Template:Acetylcholine metabolism and transport modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Acetylcholine_metabolism_and_transport_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Acetylcholine" title="Acetylcholine">Acetylcholine</a> <a href="/wiki/Metabolism" title="Metabolism">metabolism</a> and <a href="/wiki/Neurotransmitter_transporter" title="Neurotransmitter transporter">transport</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Enzyme" title="Enzyme">Enzyme</a><br /><small>(<a href="/wiki/Enzyme_modulator" title="Enzyme modulator">modulators</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Choline_acetyltransferase" title="Choline acetyltransferase"><abbr title="Choline acetyltransferase">ChAT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Choline acetyltransferase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/w/index.php?title=1-(-Benzoylethyl)pyridinium&action=edit&redlink=1" class="new" title="1-(-Benzoylethyl)pyridinium (page does not exist)">1-(-Benzoylethyl)pyridinium</a></li> <li><a href="/w/index.php?title=2-(%CE%B1-Naphthoyl)ethyltrimethylammonium&action=edit&redlink=1" class="new" title="2-(α-Naphthoyl)ethyltrimethylammonium (page does not exist)">2-(α-Naphthoyl)ethyltrimethylammonium</a></li> <li><a href="/w/index.php?title=3-Chloro-4-stillbazole&action=edit&redlink=1" class="new" title="3-Chloro-4-stillbazole (page does not exist)">3-Chloro-4-stillbazole</a></li> <li><a href="/w/index.php?title=4-(1-Naphthylvinyl)pyridine&action=edit&redlink=1" class="new" title="4-(1-Naphthylvinyl)pyridine (page does not exist)">4-(1-Naphthylvinyl)pyridine</a></li> <li><a href="/w/index.php?title=Acetylseco_hemicholinium-3&action=edit&redlink=1" class="new" title="Acetylseco hemicholinium-3 (page does not exist)">Acetylseco hemicholinium-3</a></li> <li><a href="/w/index.php?title=Acryloylcholine&action=edit&redlink=1" class="new" title="Acryloylcholine (page does not exist)">Acryloylcholine</a></li> <li><a href="/wiki/AF64A" class="mw-redirect" title="AF64A">AF64A</a></li> <li><a href="/w/index.php?title=(E)-1-Methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine&action=edit&redlink=1" class="new" title="(E)-1-Methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine (page does not exist)">B115</a></li> <li><a href="/w/index.php?title=(2-Benzoylethyl)trimethylammonium&action=edit&redlink=1" class="new" title="(2-Benzoylethyl)trimethylammonium (page does not exist)">BETA</a></li> <li><a href="/w/index.php?title=N,N-Dimethylamino-2-ethoxyimino-2-adamantane&action=edit&redlink=1" class="new" title="N,N-Dimethylamino-2-ethoxyimino-2-adamantane (page does not exist)">CM-54,903</a></li> <li><a href="/w/index.php?title=N,N-Dimethylaminoethylacrylate&action=edit&redlink=1" class="new" title="N,N-Dimethylaminoethylacrylate (page does not exist)">N,N-Dimethylaminoethylacrylate</a></li> <li><a href="/w/index.php?title=N,N-Dimethylaminoethylchloroacetate&action=edit&redlink=1" class="new" title="N,N-Dimethylaminoethylchloroacetate (page does not exist)">N,N-Dimethylaminoethylchloroacetate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Acetylcholinesterase" title="Acetylcholinesterase"><abbr title="Acetylcholinesterase">AChE</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Acetylcholinesterase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/Acetylcholinesterase_inhibitor" title="Acetylcholinesterase inhibitor">Inhibitors</a>:</b> <i>Reversible:</i> Carbamates: <a href="/wiki/Aldicarb" title="Aldicarb">Aldicarb</a></li> <li><a href="/wiki/Aminocarb" title="Aminocarb">Aminocarb</a></li> <li><a href="/wiki/Bendiocarb" title="Bendiocarb">Bendiocarb</a></li> <li><a href="/w/index.php?title=Bufencarb&action=edit&redlink=1" class="new" title="Bufencarb (page does not exist)">Bufencarb</a></li> <li><a href="/wiki/Carbaryl" title="Carbaryl">Carbaryl</a></li> <li><a href="/wiki/Carbendazim" title="Carbendazim">Carbendazim</a></li> <li><a href="/w/index.php?title=Carbetamide&action=edit&redlink=1" class="new" title="Carbetamide (page does not exist)">Carbetamide</a></li> <li><a href="/wiki/Carbofuran" title="Carbofuran">Carbofuran</a></li> <li><a href="/wiki/Carbosulfan" title="Carbosulfan">Carbosulfan</a></li> <li><a href="/w/index.php?title=Chlorbufam&action=edit&redlink=1" class="new" title="Chlorbufam (page does not exist)">Chlorbufam</a></li> <li><a href="/w/index.php?title=Chloropropham&action=edit&redlink=1" class="new" title="Chloropropham (page does not exist)">Chloropropham</a></li> <li><a href="/wiki/Dimetilan" title="Dimetilan">Dimetilan</a></li> <li><a href="/wiki/Ethienocarb" class="mw-redirect" title="Ethienocarb">Ethienocarb</a></li> <li><a href="/wiki/Ethiofencarb" title="Ethiofencarb">Ethiofencarb</a></li> <li><a href="/wiki/Fenobucarb" title="Fenobucarb">Fenobucarb</a></li> <li><a href="/wiki/Formetanate" title="Formetanate">Formetanate</a></li> <li><a href="/wiki/Formparanate" title="Formparanate">Formparanate</a></li> <li><a href="/wiki/Methiocarb" title="Methiocarb">Methiocarb</a></li> <li><a href="/wiki/Methomyl" title="Methomyl">Methomyl</a></li> <li><a href="/wiki/Metolcarb" title="Metolcarb">Metolcarb</a></li> <li><a href="/wiki/Miotine" title="Miotine">Miotine</a></li> <li><a href="/wiki/Oxamyl" title="Oxamyl">Oxamyl</a></li> <li><a href="/w/index.php?title=Phenmedipham&action=edit&redlink=1" class="new" title="Phenmedipham (page does not exist)">Phenmedipham</a></li> <li><a href="/w/index.php?title=Pinmicarb&action=edit&redlink=1" class="new" title="Pinmicarb (page does not exist)">Pinmicarb</a></li> <li><a href="/wiki/Pirimicarb" title="Pirimicarb">Pirimicarb</a></li> <li><a href="/wiki/Promecarb" title="Promecarb">Promecarb</a></li> <li><a href="/wiki/Propamocarb" title="Propamocarb">Propamocarb</a></li> <li><a href="/w/index.php?title=Propham&action=edit&redlink=1" class="new" title="Propham (page does not exist)">Propham</a></li> <li><a href="/wiki/Propoxur" title="Propoxur">Propoxur</a></li> <li><a href="/w/index.php?title=Thiodicarb&action=edit&redlink=1" class="new" title="Thiodicarb (page does not exist)">Thiodicarb</a></li> <li><a href="/wiki/Thiofanox" title="Thiofanox">Thiofanox</a>; Stigmines: <a href="/wiki/Distigmine" title="Distigmine">Distigmine</a></li> <li><a href="/w/index.php?title=Eptastigmine&action=edit&redlink=1" class="new" title="Eptastigmine (page does not exist)">Eptastigmine</a></li> <li><a href="/w/index.php?title=Ganstigmine&action=edit&redlink=1" class="new" title="Ganstigmine (page does not exist)">Ganstigmine</a></li> <li><a href="/wiki/Neostigmine" title="Neostigmine">Neostigmine</a> <a href="/wiki/Neostigmine/glycopyrronium_bromide" title="Neostigmine/glycopyrronium bromide">+glycopyrronium bromide</a></li> <li><a href="/wiki/Phenserine" title="Phenserine">Phenserine</a></li> <li><a href="/wiki/Physostigmine" title="Physostigmine">Physostigmine</a></li> <li><a href="/wiki/Pyridostigmine" title="Pyridostigmine">Pyridostigmine</a></li> <li><a href="/w/index.php?title=Quilostigmine&action=edit&redlink=1" class="new" title="Quilostigmine (page does not exist)">Quilostigmine</a></li> <li><a href="/wiki/Rivastigmine" title="Rivastigmine">Rivastigmine</a></li> <li><a href="/w/index.php?title=Terestigmine&action=edit&redlink=1" class="new" title="Terestigmine (page does not exist)">Terestigmine</a>; Others: <a href="/wiki/Acotiamide" title="Acotiamide">Acotiamide</a></li> <li><a href="/wiki/Ambenonium" class="mw-redirect" title="Ambenonium">Ambenonium</a></li> <li><a href="/wiki/Caffeine" title="Caffeine">Caffeine</a></li> <li><a href="/wiki/Donepezil" title="Donepezil">Donepezil</a></li> <li><a href="/wiki/EA-3990" title="EA-3990">EA-3990</a></li> <li><a href="/wiki/EA-4056" title="EA-4056">EA-4056</a></li> <li><a href="/wiki/Edrophonium" title="Edrophonium">Edrophonium</a></li> <li><a href="/wiki/Galantamine" title="Galantamine">Galantamine</a></li> <li><a href="/wiki/Huperzine_A" title="Huperzine A">Huperzine A</a></li> <li><a href="/w/index.php?title=Huprine_W&action=edit&redlink=1" class="new" title="Huprine W (page does not exist)">Huprine W</a></li> <li><a href="/wiki/Huprine_X" title="Huprine X">Huprine X</a></li> <li><a href="/w/index.php?title=Huprine_Y&action=edit&redlink=1" class="new" title="Huprine Y (page does not exist)">Huprine Y</a></li> <li><a href="/wiki/Ipidacrine" title="Ipidacrine">Ipidacrine</a></li> <li><a href="/wiki/Itopride" title="Itopride">Itopride</a></li> <li><a href="/wiki/Ladostigil" title="Ladostigil">Ladostigil</a></li> <li><a href="/wiki/Minaprine" title="Minaprine">Minaprine</a></li> <li><a href="/wiki/Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium_bromide)" title="Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)">Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)</a></li> <li><a href="/wiki/T-1123" title="T-1123">T-1123</a></li> <li><a href="/wiki/T-1152" title="T-1152">T-1152</a></li> <li><a href="/wiki/T-1194" title="T-1194">T-1194</a></li> <li><a href="/wiki/TL-599" title="TL-599">TL-599</a></li> <li><a href="/wiki/TL-1238" title="TL-1238">TL-1238</a></li> <li><a href="/wiki/Tacrine" title="Tacrine">Tacrine</a></li> <li><a href="/w/index.php?title=Zanapezil&action=edit&redlink=1" class="new" title="Zanapezil (page does not exist)">Zanapezil</a></li></ul> <ul><li><i>Irreversible:</i> Organophosphates: <a href="/wiki/2-Ethoxycarbonyl-1-methylvinyl_cyclohexyl_methylphosphonate" title="2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate">2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate</a></li> <li><a href="/wiki/Acephate" title="Acephate">Acephate</a></li> <li><a href="/wiki/Armine_(chemical)" title="Armine (chemical)">Armine</a></li> <li><a href="/wiki/Azinphos-ethyl" title="Azinphos-ethyl">Azinphos-ethyl</a></li> <li><a href="/wiki/Azinphos-methyl" title="Azinphos-methyl">Azinphos-methyl</a></li> <li><a href="/wiki/BAY-29952" title="BAY-29952">BAY-29952</a></li> <li><a href="/wiki/Bensulide" title="Bensulide">Bensulide</a></li> <li><a href="/wiki/Cadusafos" title="Cadusafos">Cadusafos</a></li> <li><a href="/wiki/Carbophenothion" title="Carbophenothion">Carbophenothion</a></li> <li><a href="/wiki/Chlorethoxyfos" title="Chlorethoxyfos">Chlorethoxyfos</a></li> <li><a href="/wiki/Chlorfenvinphos" title="Chlorfenvinphos">Chlorfenvinphos</a></li> <li><a href="/wiki/Chlorpyrifos" title="Chlorpyrifos">Chlorpyrifos</a></li> <li><a href="/wiki/Chlorpyrifos-methyl" class="mw-redirect" title="Chlorpyrifos-methyl">Chlorpyrifos-methyl</a></li> <li><a href="/wiki/Coumaphos" title="Coumaphos">Coumaphos</a></li> <li><a href="/wiki/Crotylsarin" title="Crotylsarin">Crotylsarin</a></li> <li><a href="/wiki/Cyanophos" title="Cyanophos">Cyanophos</a></li> <li><a href="/wiki/Cyclosarin" title="Cyclosarin">Cyclosarin (GF)</a></li> <li><a href="/wiki/Demephion" title="Demephion">Demephion</a></li> <li><a href="/wiki/Demeton" title="Demeton">Demeton</a></li> <li><a href="/wiki/Demeton-S-methyl" title="Demeton-S-methyl">Demeton-S-methyl</a></li> <li><a href="/wiki/Dialifor" title="Dialifor">Dialifor</a></li> <li><a href="/wiki/Diazinon" title="Diazinon">Diazinon</a></li> <li><a href="/wiki/Dichlorvos" title="Dichlorvos">Dichlorvos</a></li> <li><a href="/wiki/Dicrotophos" title="Dicrotophos">Dicrotophos</a></li> <li><a href="/wiki/Dicyclohexyl_phosphorofluoridate" title="Dicyclohexyl phosphorofluoridate">Dicyclohexyl phosphorofluoridate</a></li> <li><a href="/wiki/Diisopropylphosphate" title="Diisopropylphosphate">Diisopropylphosphate</a></li> <li><a href="/wiki/Diisopropyl_fluorophosphate" title="Diisopropyl fluorophosphate">Diisopropyl fluorophosphate</a></li> <li><a href="/wiki/Dimefox" title="Dimefox">Dimefox</a></li> <li><a href="/wiki/Dimethoate" title="Dimethoate">Dimethoate</a></li> <li><a href="/wiki/Dimethyl_4-(methylthio)phenyl_phosphate" title="Dimethyl 4-(methylthio)phenyl phosphate">Dimethyl 4-(methylthio)phenyl phosphate</a></li> <li><a href="/wiki/Dioxathion" title="Dioxathion">Dioxathion</a></li> <li><a href="/wiki/Disulfoton" title="Disulfoton">Disulfoton</a></li> <li><a href="/wiki/EA-2012" title="EA-2012">EA-2012</a></li> <li><a href="/wiki/EA-2054" title="EA-2054">EA-2054</a></li> <li><a href="/wiki/EA-2098" title="EA-2098">EA-2098</a></li> <li><a href="/wiki/EA-2192" title="EA-2192">EA-2192</a></li> <li><a href="/wiki/EA-2613" title="EA-2613">EA-2613</a></li> <li><a href="/wiki/EA-3148" title="EA-3148">EA-3148</a></li> <li><a href="/wiki/EA-4352" title="EA-4352">EA-4352</a></li> <li><a href="/wiki/Echothiophate" title="Echothiophate">Echothiophate</a></li> <li><a href="/wiki/Ethylsarin" title="Ethylsarin">Ethylsarin (GE)</a></li> <li><a href="/wiki/Endothion" title="Endothion">Endothion</a></li> <li><a href="/wiki/EPN_(insecticide)" title="EPN (insecticide)">EPN</a></li> <li><a href="/wiki/Ethion" title="Ethion">Ethion</a></li> <li><a href="/wiki/Ethoprop" class="mw-redirect" title="Ethoprop">Ethoprop</a></li> <li><a href="/wiki/Fenamiphos" title="Fenamiphos">Fenamiphos</a></li> <li><a href="/wiki/Fenitrothion" title="Fenitrothion">Fenitrothion</a></li> <li><a href="/wiki/Fenthion" title="Fenthion">Fenthion</a></li> <li><a href="/wiki/Fluorotabun" title="Fluorotabun">Fluorotabun</a></li> <li><a href="/wiki/Fonofos" title="Fonofos">Fonofos</a></li> <li><a href="/wiki/Formothion" title="Formothion">Formothion</a></li> <li><a href="/w/index.php?title=Fosthiazate&action=edit&redlink=1" class="new" title="Fosthiazate (page does not exist)">Fosthiazate</a></li> <li><a href="/wiki/GD-42" title="GD-42">GD-42</a></li> <li><a href="/wiki/GH_(nerve_agent)" title="GH (nerve agent)">GH</a></li> <li><a href="/w/index.php?title=GT-45&action=edit&redlink=1" class="new" title="GT-45 (page does not exist)">GT-45</a></li> <li><a href="/wiki/GV_(nerve_agent)" title="GV (nerve agent)">GV</a></li> <li><a href="/wiki/Guanitoxin" title="Guanitoxin">Guanitoxin</a></li> <li><a href="/wiki/Hexaethyl_tetraphosphate" title="Hexaethyl tetraphosphate">Hexaethyl tetraphosphate (HETP)</a></li> <li><a href="/wiki/Isofluorophate" class="mw-redirect" title="Isofluorophate">Isofluorophate</a></li> <li><a href="/wiki/Isoxathion" title="Isoxathion">Isoxathion</a></li> <li><a href="/wiki/Leptophos" title="Leptophos">Leptophos</a></li> <li><a href="/wiki/Malaoxon" title="Malaoxon">Malaoxon</a></li> <li><a href="/wiki/Malathion" title="Malathion">Malathion</a></li> <li><a href="/w/index.php?title=Mazidox&action=edit&redlink=1" class="new" title="Mazidox (page does not exist)">Mazidox</a></li> <li><a href="/wiki/Methamidophos" title="Methamidophos">Methamidophos</a></li> <li><a href="/wiki/Methidathion" title="Methidathion">Methidathion</a></li> <li><a href="/wiki/Methyl_phenkapton" title="Methyl phenkapton">Methyl phenkapton</a></li> <li><a href="/wiki/Methylfluorophosphonylcholine" title="Methylfluorophosphonylcholine">Methylfluorophosphonylcholine (MFPCh)</a></li> <li><a href="/wiki/Metrifonate" title="Metrifonate">Metrifonate</a></li> <li><a href="/wiki/Mevinphos" title="Mevinphos">Mevinphos</a></li> <li><a href="/wiki/Mipafox" title="Mipafox">Mipafox</a></li> <li><a href="/wiki/Monocrotophos" title="Monocrotophos">Monocrotophos</a></li> <li><a href="/wiki/MSPI_(nerve_agent)" title="MSPI (nerve agent)">MSPI</a></li> <li><a href="/wiki/Naled" title="Naled">Naled</a></li> <li><a href="/wiki/Novichok_agent" class="mw-redirect" title="Novichok agent">Novichok agent</a></li> <li><a href="/wiki/Omethoate" title="Omethoate">Omethoate</a></li> <li><a href="/wiki/Oxydemeton-methyl" title="Oxydemeton-methyl">Oxydemeton-methyl</a></li> <li><a href="/wiki/Paraoxon" title="Paraoxon">Paraoxon</a></li> <li><a href="/wiki/Parathion" title="Parathion">Parathion</a></li> <li><a href="/wiki/Parathion-methyl" class="mw-redirect" title="Parathion-methyl">Parathion-methyl</a></li> <li><a href="/wiki/Phorate" title="Phorate">Phorate</a></li> <li><a href="/wiki/Phosalone" title="Phosalone">Phosalone</a></li> <li><a href="/wiki/Phosfolan" title="Phosfolan">Phosfolan</a></li> <li><a href="/wiki/Phosmet" title="Phosmet">Phosmet</a></li> <li><a href="/wiki/Phosphamidon" title="Phosphamidon">Phosphamidon</a></li> <li><a href="/wiki/Phoxim" title="Phoxim">Phoxim</a></li> <li><a href="/wiki/Pirimiphos-methyl" title="Pirimiphos-methyl">Pirimiphos-methyl</a></li> <li><a href="/wiki/Profenofos" title="Profenofos">Profenofos</a></li> <li><a href="/wiki/Prothoate" title="Prothoate">Prothoate</a></li> <li><a href="/wiki/R-16661" title="R-16661">R-16661</a></li> <li><a href="/w/index.php?title=Ro_3-0340&action=edit&redlink=1" class="new" title="Ro 3-0340 (page does not exist)">Ro 3-0340</a></li> <li><a href="/w/index.php?title=Ro_3-0346&action=edit&redlink=1" class="new" title="Ro 3-0346 (page does not exist)">Ro 3-0346</a></li> <li><a href="/w/index.php?title=Ro_3-0347&action=edit&redlink=1" class="new" title="Ro 3-0347 (page does not exist)">Ro 3-0347</a></li> <li><a href="/w/index.php?title=Ro_3-0351&action=edit&redlink=1" class="new" title="Ro 3-0351 (page does not exist)">Ro 3-0351</a></li> <li><a href="/w/index.php?title=Ro_3-0352&action=edit&redlink=1" class="new" title="Ro 3-0352 (page does not exist)">Ro 3-0352</a></li> <li><a href="/w/index.php?title=Ro_3-0397&action=edit&redlink=1" class="new" title="Ro 3-0397 (page does not exist)">Ro 3-0397</a></li> <li><a href="/w/index.php?title=Ro_3-0411&action=edit&redlink=1" class="new" title="Ro 3-0411 (page does not exist)">Ro 3-0411</a></li> <li><a href="/wiki/Ro_3-0412" title="Ro 3-0412">Ro 3-0412</a></li> <li><a href="/w/index.php?title=Ro_3-0417&action=edit&redlink=1" class="new" title="Ro 3-0417 (page does not exist)">Ro 3-0417</a></li> <li><a href="/wiki/Ro_3-0419" title="Ro 3-0419">Ro 3-0419</a></li> <li><a href="/wiki/Ro_3-0422" title="Ro 3-0422">Ro 3-0422</a></li> <li><a href="/w/index.php?title=Ro_3-0433&action=edit&redlink=1" class="new" title="Ro 3-0433 (page does not exist)">Ro 3-0433</a></li> <li><a href="/w/index.php?title=Ronnel&action=edit&redlink=1" class="new" title="Ronnel (page does not exist)">Ronnel</a></li> <li><a href="/wiki/Sarin" title="Sarin">Sarin (GB)</a></li> <li><a href="/wiki/Schradan" title="Schradan">Schradan</a></li> <li><a href="/wiki/Soman" title="Soman">Soman (GD)</a></li> <li><a href="/wiki/Sulfotep" title="Sulfotep">Sulfotep (TEDP)</a></li> <li><a href="/wiki/Tabun_(nerve_agent)" title="Tabun (nerve agent)">Tabun (GA)</a></li> <li><a href="/wiki/Tebupirimfos" title="Tebupirimfos">Tebupirimfos</a></li> <li><a href="/wiki/Temefos" title="Temefos">Temefos</a></li> <li><a href="/wiki/Terbufos" title="Terbufos">Terbufos</a></li> <li><a href="/wiki/Tetrachlorvinphos" title="Tetrachlorvinphos">Tetrachlorvinphos</a></li> <li><a href="/wiki/Tetraethyl_pyrophosphate" title="Tetraethyl pyrophosphate">Tetraethyl pyrophosphate (TEPP)</a></li> <li><a href="/wiki/Triazofos" title="Triazofos">Triazofos</a></li> <li><a href="/w/index.php?title=Tribufos&action=edit&redlink=1" class="new" title="Tribufos (page does not exist)">Tribufos</a></li> <li><a href="/wiki/Trichlorfon" class="mw-redirect" title="Trichlorfon">Trichlorfon</a></li> <li><a href="/wiki/Trichloronate" title="Trichloronate">Trichloronate</a></li> <li><a href="/wiki/Tricresyl_phosphate" title="Tricresyl phosphate">Tricresyl phosphate</a></li> <li><a href="/wiki/VE_(nerve_agent)" title="VE (nerve agent)">VE</a></li> <li><a href="/wiki/VG_(nerve_agent)" title="VG (nerve agent)">VG</a></li> <li><a href="/wiki/VM_(nerve_agent)" title="VM (nerve agent)">VM</a></li> <li><a href="/wiki/VP_(nerve_agent)" class="mw-redirect" title="VP (nerve agent)">VP</a></li> <li><a href="/wiki/VS_(nerve_agent)" title="VS (nerve agent)">VS</a></li> <li><a href="/wiki/VR_(nerve_agent)" title="VR (nerve agent)">VR</a></li> <li><a href="/wiki/VX_(nerve_agent)" title="VX (nerve agent)">VX</a>; Others: <a href="/wiki/Demecarium" class="mw-redirect" title="Demecarium">Demecarium</a></li> <li><a href="/wiki/Fasciculin" title="Fasciculin">Fasciculins (green mamba toxins)</a> (<a href="/w/index.php?title=Fasciculin_1&action=edit&redlink=1" class="new" title="Fasciculin 1 (page does not exist)">1</a>, <a href="/w/index.php?title=Fasciculin_2&action=edit&redlink=1" class="new" title="Fasciculin 2 (page does not exist)">2</a>, <a href="/w/index.php?title=Fasciculin_3&action=edit&redlink=1" class="new" title="Fasciculin 3 (page does not exist)">3</a>, <a href="/w/index.php?title=Fasciculin_4&action=edit&redlink=1" class="new" title="Fasciculin 4 (page does not exist)">4</a>)</li> <li><a href="/wiki/Onchidal" title="Onchidal">Onchidal</a> (<i><a href="/wiki/Onchidella_binneyi" title="Onchidella binneyi">Onchidella binneyi</a></i>)</li> <li><a href="/wiki/Methanesulfonyl_fluoride" title="Methanesulfonyl fluoride">Methanesulfonyl fluoride</a></li></ul> <ul><li><i>Unsorted:</i> <a href="/wiki/%CE%91-Pinene" title="Α-Pinene">α-Pinene</a></li> <li><a href="/wiki/%CE%91-Viniferin" title="Α-Viniferin">α-Viniferin</a></li> <li><a href="/wiki/Affinine" title="Affinine">Affinine</a></li> <li><a href="/wiki/Affinisine" title="Affinisine">Affinisine</a></li> <li><a href="/wiki/Arisugacin_A" title="Arisugacin A">Arisugacin A</a></li> <li><a href="/wiki/Bulbocapnine" title="Bulbocapnine">Bulbocapnine</a></li> <li><a href="/wiki/Conodurine" title="Conodurine">Conodurine</a></li> <li><a href="/wiki/Coronaridine" title="Coronaridine">Coronaridine</a></li> <li><a href="/wiki/Corydaline" title="Corydaline">Corydaline</a></li> <li><a href="/wiki/Corynoline" title="Corynoline">Corynoline</a></li> <li><a href="/wiki/Crimidine" title="Crimidine">Crimidine</a></li> <li><a href="/wiki/Cyclanoline" title="Cyclanoline">Cyclanoline</a></li> <li><a href="/wiki/Cymserine" title="Cymserine">Cymserine</a></li> <li><a href="/wiki/Harmaline" title="Harmaline">Harmaline</a></li> <li><a href="/wiki/Kobophenol_A" title="Kobophenol A">Kobophenol A</a></li> <li><a href="/wiki/Lactucopicrin" title="Lactucopicrin">Lactucopicrin</a></li> <li><a href="/wiki/Lycorine" title="Lycorine">Lycorine</a></li> <li><a href="/wiki/Phosacetim" title="Phosacetim">Phosacetim</a></li> <li><a href="/wiki/Rosmarinic_acid" title="Rosmarinic acid">Rosmarinic acid</a></li> <li><a href="/wiki/Stercuronium_iodide" title="Stercuronium iodide">Stercuronium iodide</a></li> <li><a href="/wiki/Taspine" title="Taspine">Taspine</a></li> <li><a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">Tetrahydrocannabinol</a></li> <li><a href="/wiki/Ungeremine" title="Ungeremine">Ungeremine</a></li> <li><a href="/wiki/Ungiminorine" title="Ungiminorine">Ungiminorine</a></li> <li><a href="/wiki/Dimethylcarbamoyl_fluoride" title="Dimethylcarbamoyl fluoride">Dimethylcarbamoyl fluoride</a></li> <li><a href="/wiki/BW284C51" title="BW284C51">BW284C51</a></li> <li><a href="/wiki/TMTFA" title="TMTFA">TMTFA</a></li> <li><a href="/wiki/3152_CT" title="3152 CT">3152 CT</a></li></ul> <ul><li><a href="/wiki/Cholinesterase_reactivator" title="Cholinesterase reactivator">Reactivators</a>: <a href="/wiki/Asoxime_chloride" title="Asoxime chloride">Asoxime chloride</a></li> <li><a href="/w/index.php?title=Methoxime&action=edit&redlink=1" class="new" title="Methoxime (page does not exist)">Methoxime</a></li> <li><a href="/wiki/Obidoxime" title="Obidoxime">Obidoxime</a></li> <li><a href="/wiki/Pralidoxime" title="Pralidoxime">Pralidoxime</a></li> <li><a href="/wiki/Trimedoxime_bromide" title="Trimedoxime bromide">Trimedoxime bromide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a class="mw-selflink selflink"><abbr title="Butyrylcholinesterase">BChE</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Butyrylcholinesterase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/wiki/Affinine" title="Affinine">Affinine</a></li> <li><a href="/wiki/Affinisine" title="Affinisine">Affinisine</a></li> <li><a href="/wiki/Conodurine" title="Conodurine">Conodurine</a></li> <li><a href="/wiki/Cymserine" title="Cymserine">Cymserine</a></li> <li><a href="/wiki/Ladostigil" title="Ladostigil">Ladostigil</a></li> <li><a href="/wiki/Profenamine" title="Profenamine">Profenamine (ethopropazine)</a></li> <li><a href="/wiki/Rivastigmine" title="Rivastigmine">Rivastigmine</a></li> <li><a href="/wiki/Tacrine" title="Tacrine">Tacrine</a></li> <li><a href="/w/index.php?title=ZINC-12613047&action=edit&redlink=1" class="new" title="ZINC-12613047 (page does not exist)">ZINC-12613047</a></li> <li>Many of the other AChE inhibitors listed above</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Neurotransmitter_transporter" title="Neurotransmitter transporter">Transporter</a><br /><small>(<a href="/wiki/Transporter_modulator" class="mw-redirect" title="Transporter modulator">modulators</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Choline_transporter" title="Choline transporter"><abbr title="Choline transporter">CHT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Choline transporter</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/wiki/Hemicholinium-3" title="Hemicholinium-3">Hemicholinium-3 (hemicholine)</a></li> <li><a href="/wiki/Triethylcholine" title="Triethylcholine">Triethylcholine</a></li></ul> <ul><li><b>Enhancers:</b> <a href="/wiki/Coluracetam" title="Coluracetam">Coluracetam</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Vesicular_acetylcholine_transporter" title="Vesicular acetylcholine transporter"><abbr title="Vesicular acetylcholine transporter">VAChT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Vesicular acetylcholine transporter</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/wiki/Vesamicol" title="Vesamicol">Vesamicol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Neurotransmitter_release" class="mw-redirect" title="Neurotransmitter release">Release</a><br /><small>(<a href="/wiki/Release_modulator" title="Release modulator">modulators</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Release_inhibitor" class="mw-redirect" title="Release inhibitor">Inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/Synaptosomal-associated_protein_25" class="mw-redirect" title="Synaptosomal-associated protein 25"><abbr title="Synaptosomal-associated protein 25">SNAP-25</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Synaptosomal-associated protein 25</span> inactivators:</b> <a href="/wiki/Botulinum_toxin" title="Botulinum toxin">Botulinum toxin</a> (<a href="/wiki/Botulinum_toxin_A" class="mw-redirect" title="Botulinum toxin A">A</a>, <a href="/wiki/Botulinum_toxin_C" class="mw-redirect" title="Botulinum toxin C">C</a>, <a href="/wiki/Botulinum_toxin_E" class="mw-redirect" title="Botulinum toxin E">E</a>)</li></ul> <ul><li><b><a href="/wiki/Vesicle-associated_membrane_protein" title="Vesicle-associated membrane protein"><abbr title="Vesicle-associated membrane protein">VAMP</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Vesicle-associated membrane protein</span> inactivators:</b> <a href="/wiki/Botulinum_toxin" title="Botulinum toxin">Botulinum toxin</a> (<a href="/wiki/Botulinum_toxin_B" class="mw-redirect" title="Botulinum toxin B">B</a>, <a href="/wiki/Botulinum_toxin_D" class="mw-redirect" title="Botulinum toxin D">D</a>, <a href="/wiki/Botulinum_toxin_F" class="mw-redirect" title="Botulinum toxin F">F</a>, <a href="/wiki/Botulinum_toxin_G" class="mw-redirect" title="Botulinum toxin G">G</a>)</li></ul> <ul><li><b>Others:</b> <a href="/wiki/Bungarotoxin" title="Bungarotoxin">Bungarotoxins</a> (<a href="/wiki/Beta-Bungarotoxin" class="mw-redirect" title="Beta-Bungarotoxin">β-bungarotoxin</a>, <a href="/wiki/%CE%93-bungarotoxin" class="mw-redirect" title="Γ-bungarotoxin">γ-bungarotoxin</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Release_enhancer" class="mw-redirect" title="Release enhancer">Enhancers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/Latrophilin" title="Latrophilin"><abbr title="Latrophilin">LPHN</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Latrophilin</span> agonists:</b> <a href="/wiki/Alpha-Latrotoxin" class="mw-redirect" title="Alpha-Latrotoxin">α-Latrotoxin</a></li></ul> <ul><li><b>Others:</b> Atracotoxins (e.g., <a href="/wiki/Robustoxin" class="mw-redirect" title="Robustoxin">robustoxin</a>, <a href="/wiki/Versutoxin" title="Versutoxin">versutoxin</a>)</li> <li><a href="/wiki/Crotoxin" title="Crotoxin">Crotoxin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></dd> <dd><a href="/wiki/Template:Muscarinic_acetylcholine_receptor_modulators" title="Template:Muscarinic acetylcholine receptor modulators">Muscarinic acetylcholine receptor modulators</a></dd> <dd><a href="/wiki/Template:Nicotinic_acetylcholine_receptor_modulators" title="Template:Nicotinic acetylcholine receptor modulators">Nicotinic acetylcholine receptor modulators</a></dd></dl> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Butyrylcholinesterase&oldid=1226276650">https://en.wikipedia.org/w/index.php?title=Butyrylcholinesterase&oldid=1226276650</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_3" title="Category:Genes on human chromosome 3">Genes on human chromosome 3</a></li><li><a href="/wiki/Category:Enzymes" 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