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</ol> <a id="main-content"></a> <div class="region region-content"> <section id="block-system-main" class="block block-system clearfix"> <div class="panel-display" id="issue-toc-page"> <div class="hero"> <div class="panel-pane pane-page-title" > <div class="pane-content"> <h1 id="page-title">23 November 2024(vol 387, issue 8449)</h1> </div> </div> <div class="hero-wrapper"> <div class="hero-content" style="position: relative; left: 0px; top: 35.5px;"> </div>  </div>  </div>  <div class="row"> <div class="left-content col-xs-12 col-sm-8 col-md-8 col-lg-8"> <article> <div class="panel-pane pane-highwire-markup" > <div class="pane-content"> <div class="highwire-markup"><div class="issue-toc"><h2 class="toc-heading" id="this-week">This Week</h2><div class="toc-pdf-download"><a href="/bmj/section-pdf/1103610?path=/bmj/387/8449/This_Week.full.pdf">Download PDF</a></div><ul class="toc-section"><li class="first odd toc-item"><div class="toc-citation"><div class="highwire-article-citation 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Access</li> </ul></div></div> </div> </div></div></li><li class="even toc-item"><div class="toc-citation"><div class="highwire-article-citation highwire-citation-type-highwire-article node1103367" data-node-nid="1103367" id="node-1103367--2121308226" data-pisa="bmj;387/nov18_7/e079525" data-pisa-master="bmj;bmj-2024-079525" data-apath="/bmj/387/bmj-2024-079525.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmj-toc clearfix"> <a href="/content/387/bmj-2024-079525" class="highwire-cite-linked-title"><span class="highwire-cite-title">Efficacy and safety of fezolinetant for moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy: phase 3b randomised controlled trial</span></a> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">BMJ </span><span class="highwire-cite-metadata-date highwire-cite-metadata">2024; </span><span 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