2024 Nobel Prize in Chemistry Awarded to Pioneering Advances in Protein Design and Structure Prediction

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The prize was also awarded to Demis Hassabis, Co-Founder and CEO of Google DeepMind, and John Jumper, Director at Google DeepMind, for their outstanding work in protein structure prediction.</p> <p>Baker's significant contributions to protein design began in 2003 when he successfully created new proteins using amino acids. He was able to create proteins that did not exist in nature. Since then, Baker’s research group has continued to push the boundaries of science, designing a variety of proteins with entirely new functions. These proteins have significant potential, with applications ranging from pharmaceuticals and vaccines to nanomaterials.</p> <p>Heiner Linke, Chair of the Nobel Committee for Chemistry, reemphasised the magnitude of Baker’s achievements: "He developed computational tools that now allow scientists to design spectacular new proteins with entirely novel shapes and functions, opening endless possibilities for the benefit of humankind."</p> <p><strong>Related:</strong></p> <ul> <li><a href="https://oxfordglobal.com/discovery-development/resources/neuralplexer2-has-alphafold2-met-its-match" rel="noopener" target="_blank">NeuralPLexer2 - Has AlphaFold2 Met Its Match?</a></li> <li><a href="https://oxfordglobal.com/discovery-development/resources/new-trailblazer-profluent-launches-its-ai-enabled-opencrispr-1-to-edit-the-human-genome" rel="noopener" target="_blank">New Trailblazer Profluent Launches its AI-enabled OpenCRISPR-1 to Edit the Human Genome</a></li> <li><a href="https://oxfordglobal.com/discovery-development/resources/alphafold-and-drug-design-has-ai-solved-biologys-grand-challenge" rel="noopener" target="_blank">AlphaFold and Drug Design: Has AI Solved Biology’s ‘Grand Challenge?’</a></li> </ul> <p>The <a href="https://www.nature.com/scitable/topicpage/protein-structure-14122136/#:~:text=Proteins%20are%20built%20as%20chains,well%2Dadapted%20for%20their%20functions." rel="noopener" target="_blank">way amino acids fold into three-dimensional (3D) structures determines a protein’s function</a>. There are approximately 20 different amino acids that combine in various sequences to form proteins in the human body. Molecular biologist Cyrus Levinthal famously estimated that just <a href="https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202100136" rel="noopener" target="_blank">one protein could have up to 10³⁰⁰ possible conformations</a>. For decades, scientists have attempted to predict a protein’s 3D structure from its amino acid sequence. This challenging and time-consuming process  has posed significant obstacles for researchers over the last 50 years.</p> <p>However, in 2020, Hassabis and Jumper made a critical breakthrough at Google DeepMind. Their AI model, <a href="https://www.nature.com/articles/s41392-023-01381-z" rel="noopener" target="_blank">AlphaFold2</a>, demonstrated the ability to <a href="https://www.ebi.ac.uk/training/online/courses/alphafold/accessing-and-predicting-protein-structures-with-alphafold/" rel="noopener" target="_blank">predict the structure of around 200 million proteins</a> that had been identified by researchers. The program is available for anyone to use, demonstrating the company’s commitment to democratising technology. This milestone has fundamentally transformed the field of biology, providing an invaluable tool for understanding proteins on a broad scale.</p> <p>The Nobel Prize in Chemistry award highlights the significance of AI in scientific discovery and reinforces the critical role of proteins across medicine and biotechnology. These breakthroughs have solved longstanding biological challenges. Overall, this deepened understanding of proteins is crucial for advancing both science and global health.</p> <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/discovery-development/resources/biomedgpt-adopting-a-generalist-approach-to-biomedical-ai"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Discovery%20and%20Development/BiomedGPT%20Adopting%20a%20Generalist%20Approach%20to%20Biomedical%20AI%20.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/discovery-development/resources/biomedgpt-adopting-a-generalist-approach-to-biomedical-ai"> <h4> BiomedGPT: Adopting a Generalist Approach to Biomedical AI </h4> <div class="abstract"> BiomedGPT, a versatile AI tool used for biomedical research demonstrated impressive results across a wide range of healthcare tasks. </div> <div class="read-more"> <a href="/discovery-development/resources/biomedgpt-adopting-a-generalist-approach-to-biomedical-ai" class="read-more-link">Read More</a> </div></a> </div> </div> <div class="article"> <a href="/discovery-development/resources/goserelin-acetate-vitaldose-eva-implant"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Documents/White%20paper%20upload%20LS%206-11-24/Discovery%20%26%20Development%20Whitepaper.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/discovery-development/resources/goserelin-acetate-vitaldose-eva-implant"> <h4> Goserelin Acetate – VitalDose® EVA Implant </h4> <div class="abstract"> </div> <div class="read-more"> <a href="/discovery-development/resources/goserelin-acetate-vitaldose-eva-implant" class="read-more-link">Read More</a> </div></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="newsletter-cta"> <h2 class="heading">Subscribe to our newsletter</h2> <div class="message"> Sign up for our monthly Newsletter to keep up with all things Discovery & Development </div> <div class="button-wrapper"> <a href="#" class="button hs-cta-trigger-button hs-cta-trigger-button-177049184347">Newsletter Sign-Up</a> </div> </div> </main> <div data-global-resource-path="git/og-stage/templates/partials/footer.html"><footer class="website-footer flex flex-column g-20"> <div class="footer-columns"> <div class="footer-column"> <a href="https://oxfordglobal.com" class="site-logo-link"> <img src="https://oxfordglobal.com/wp-content/uploads/2023/03/Oxford-Global-Logo-Stacked-Websize.png" class="site-logo"> </a> </div> <div class="footer-column"> <h3>Brands</h3> <ul> <li> <a href="/precision-medicine/">Precision Medicine</a> </li> <li> <a href="/discovery-development/">Discovery & Development</a> </li> <li> <a href="/nextgen-biomed/">NextGen Biomed</a> </li> </ul> </div> <div class="footer-column"> <h3>Services</h3> <ul> <li> <a href="https://oxfordglobal.com/in-person-services/"> In-Person Services </a> </li> <li> <a href="https://oxfordglobal.com/digital-marketing-services/"> Digital Marketing Services </a> </li> </ul> <h3>Upcoming Events</h3> <ul> <li> <a href="https://oxfordglobal.com/calendar/"> Event Calendar </a> </li> </ul> </div> <div class="footer-column"> <h3>Company</h3> <ul> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/about-us/"> About </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/vacancies/"> Vacancies </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/csr-policy/"> CSR Policy </a> </li> <li class="elementor-icon-list-item"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});"> Contact </a> </li> </ul> </div> <div class="footer-column"> <p> <a href="tel:+441865248455">+44 1865 248 455</a><br> <a href="mailto:help@oxfordglobal.com">help@oxfordglobal.com</a> </p> <p> <strong>Our UK Address:</strong><br> Godstow Court<br> Minns Business Park<br> Botley<br> Oxford, OX2 0JB </p> <p> <strong>Our US Address:</strong><br> 100 Cambridge Street<br> 14th Floor<br> Boston<br> MA 02114 </p> </div> </div> <div class="footer-bottom grid g-20"> <div class="span8 span12-sm span12-md flex flex-column g-10"> <div class="copyright"> © Oxford Global Marketing Ltd. 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2024 Nobel Prize in Chemistry Awarded to Pioneering Advances in Protein Design and Structure Prediction