TY - JFULL AU - Sanae Kaewnopparat and Nattha Kaewnopparat PY - 2009/8/ TI - Formulation and Evaluation of Vaginal Suppositories Containing Lactobacillus T2 - International Journal of Pharmacological and Pharmaceutical Sciences SP - 116 EP - 120 VL - 3 SN - 1307-6892 UR - https://publications.waset.org/pdf/15159 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 31, 2009 N2 - The objective of this study was to develop vaginal suppository containing lactobacillus. Four kinds of vaginal suppositories containing Lactobacillus paracasei HL32 were formulated: 1) a conventional suppository with Witepsol H-15 as a base, 2) a conventional suppository with mixed polyethylene glycols (PEGs) as a base, 3) a hollow-type suppository with Witepsol H-15 as a base and 4) a hollow-type suppository with mixed PEGs as a base. The release studies demonstrated that the hollow-type suppository with mixed PEGs as the base gave the highest release of L. paracasei HL32 and was microbiological stable after storage at 2- 8掳C over the period of 3 months. ER -