CINXE.COM

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Search results for: Kalliopi Trouli</title> <meta name="description" content="Search results for: Kalliopi Trouli"> <meta name="keywords" content="Kalliopi Trouli"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Kalliopi Trouli" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Kalliopi Trouli"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 5</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Kalliopi Trouli</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Discrete Choice Modeling in Education: Evaluating Early Childhood Educators’ Practices</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Michalis%20Linardakis">Michalis Linardakis</a>, <a href="https://publications.waset.org/abstracts/search?q=Vasilis%20Grammatikopoulos"> Vasilis Grammatikopoulos</a>, <a href="https://publications.waset.org/abstracts/search?q=Athanasios%20Gregoriadis"> Athanasios Gregoriadis</a>, <a href="https://publications.waset.org/abstracts/search?q=Kalliopi%20Trouli"> Kalliopi Trouli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Discrete choice models belong to the family of Conjoint analysis that are applied on the preferences of the respondents towards a set of scenarios that describe alternative choices. The scenarios have been pre-designed to cover all the attributes of the alternatives that may affect the choices. In this study, we examine how preschool educators integrate physical activities into their everyday teaching practices through the use of discrete choice models. One of the advantages of discrete choice models compared to other more traditional data collection methods (e.g. questionnaires and interviews that use ratings) is that the respondent is called to select among competitive and realistic alternatives, rather than objectively rate each attribute that the alternatives may have. We present the effort to construct and choose representative attributes that would cover all possible choices of the respondents, and the scenarios that have arisen. For the purposes of the study, we used a sample of 50 preschool educators in Greece that responded to 4 scenarios (from the total of 16 scenarios that the orthogonal design resulted), with each scenario having three alternative teaching practices. Seven attributes of the alternatives were used in the scenarios. For the analysis of the data, we used multinomial logit model with random effects, multinomial probit model and generalized mixed logit model. The conclusions drawn from the estimated parameters of the models are discussed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=conjoint%20analysis" title="conjoint analysis">conjoint analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=discrete%20choice%20models" title=" discrete choice models"> discrete choice models</a>, <a href="https://publications.waset.org/abstracts/search?q=educational%20data" title=" educational data"> educational data</a>, <a href="https://publications.waset.org/abstracts/search?q=multivariate%20statistical%20analysis" title=" multivariate statistical analysis"> multivariate statistical analysis</a> </p> <a href="https://publications.waset.org/abstracts/27531/discrete-choice-modeling-in-education-evaluating-early-childhood-educators-practices" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27531.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">465</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Liposome Sterile Filtration Fouling: The Impact of Transmembrane Pressure on Performance</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hercules%20Argyropoulos">Hercules Argyropoulos</a>, <a href="https://publications.waset.org/abstracts/search?q=Thomas%20F.%20Johnson"> Thomas F. Johnson</a>, <a href="https://publications.waset.org/abstracts/search?q=Nigel%20B%20Jackson"> Nigel B Jackson</a>, <a href="https://publications.waset.org/abstracts/search?q=Kalliopi%20Zourna"> Kalliopi Zourna</a>, <a href="https://publications.waset.org/abstracts/search?q=Daniel%20G.%20Bracewell"> Daniel G. Bracewell</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lipid encapsulation has become essential in drug delivery, notably for mRNA vaccines during the COVID-19 pandemic. However, their sterile filtration poses challenges due to the risk of deformation, filter fouling and product loss from adsorption onto the membrane. Choosing the right filtration membrane is crucial to maintain sterility and integrity while minimizing product loss. The objective of this study is to develop a rigorous analytical framework utilizing confocal microscopy and filtration blocking models to elucidate the fouling mechanisms of liposomes as a model system for this class of delivery vehicle during sterile filtration, particularly in response to variations in transmembrane pressure (TMP) during the filtration process. Experiments were conducted using fluorescent Lipoid S100 PC liposomes formulated by micro fluidization and characterized by Multi-Angle Dynamic Light Scattering. Dual-layer PES/PES and PES/PVDF membranes with 0.2 μm pores were used for filtration under constant pressure, cycling from 30 psi to 5 psi and back to 30 psi, with 5, 6, and 5-minute intervals. Cross-sectional membrane samples were prepared by microtome slicing and analyzed with confocal microscopy. Liposome characterization revealed a particle size range of 100-140 nm and an average concentration of 2.93x10¹¹ particles/mL. Goodness-of-fit analysis of flux decline data at varying TMPs identified the intermediate blocking model as most accurate at 30 psi and the cake filtration model at 5 psi. Membrane resistance analysis showed atypical behavior compared to therapeutic proteins, with resistance remaining below 1.38×10¹¹ m⁻¹ at 30 psi, increasing over fourfold at 5 psi, and then decreasing to 1-1.3-fold when pressure was returned to 30 psi. This suggests that increased flow/shear deforms liposomes enabling them to more effectively navigate membrane pores. Confocal microscopy indicated that liposome fouling mainly occurred in the upper parts of the dual-layer membrane. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sterile%20filtration" title="sterile filtration">sterile filtration</a>, <a href="https://publications.waset.org/abstracts/search?q=membrane%20resistance" title=" membrane resistance"> membrane resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=microfluidization" title=" microfluidization"> microfluidization</a>, <a href="https://publications.waset.org/abstracts/search?q=confocal%20microscopy" title=" confocal microscopy"> confocal microscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=liposomes" title=" liposomes"> liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=filtration%20blocking%20models" title=" filtration blocking models"> filtration blocking models</a> </p> <a href="https://publications.waset.org/abstracts/193171/liposome-sterile-filtration-fouling-the-impact-of-transmembrane-pressure-on-performance" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193171.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">19</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Developing Computational Thinking in Early Childhood Education</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kalliopi%20Kanaki">Kalliopi Kanaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Michael%20Kalogiannakis"> Michael Kalogiannakis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nowadays, in the digital era, the early acquisition of basic programming skills and knowledge is encouraged, as it facilitates students’ exposure to computational thinking and empowers their creativity, problem-solving skills, and cognitive development. More and more researchers and educators investigate the introduction of computational thinking in K-12 since it is expected to be a fundamental skill for everyone by the middle of the 21st century, just like reading, writing and arithmetic are at the moment. In this paper, a doctoral research in the process is presented, which investigates the infusion of computational thinking into science curriculum in early childhood education. The whole attempt aims to develop young children’s computational thinking by introducing them to the fundamental concepts of object-oriented programming in an enjoyable, yet educational framework. The backbone of the research is the digital environment PhysGramming (an abbreviation of Physical Science Programming), which provides children the opportunity to create their own digital games, turning them from passive consumers to active creators of technology. PhysGramming deploys an innovative hybrid schema of visual and text-based programming techniques, with emphasis on object-orientation. Through PhysGramming, young students are familiarized with basic object-oriented programming concepts, such as classes, objects, and attributes, while, at the same time, get a view of object-oriented programming syntax. Nevertheless, the most noteworthy feature of PhysGramming is that children create their own digital games within the context of physical science courses, in a way that provides familiarization with the basic principles of object-oriented programming and computational thinking, even though no specific reference is made to these principles. Attuned to the ethical guidelines of educational research, interventions were conducted in two classes of second grade. The interventions were designed with respect to the thematic units of the curriculum of physical science courses, as a part of the learning activities of the class. PhysGramming was integrated into the classroom, after short introductory sessions. During the interventions, 6-7 years old children worked in pairs on computers and created their own digital games (group games, matching games, and puzzles). The authors participated in these interventions as observers in order to achieve a realistic evaluation of the proposed educational framework concerning its applicability in the classroom and its educational and pedagogical perspectives. To better examine if the objectives of the research are met, the investigation was focused on six criteria; the educational value of PhysGramming, its engaging and enjoyable characteristics, its child-friendliness, its appropriateness for the purpose that is proposed, its ability to monitor the user’s progress and its individualizing features. In this paper, the functionality of PhysGramming and the philosophy of its integration in the classroom are both described in detail. Information about the implemented interventions and the results obtained is also provided. Finally, several limitations of the research conducted that deserve attention are denoted. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=computational%20thinking" title="computational thinking">computational thinking</a>, <a href="https://publications.waset.org/abstracts/search?q=early%20childhood%20education" title=" early childhood education"> early childhood education</a>, <a href="https://publications.waset.org/abstracts/search?q=object-oriented%20programming" title=" object-oriented programming"> object-oriented programming</a>, <a href="https://publications.waset.org/abstracts/search?q=physical%20science%20courses" title=" physical science courses"> physical science courses</a> </p> <a href="https://publications.waset.org/abstracts/90962/developing-computational-thinking-in-early-childhood-education" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/90962.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">120</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Leveraging Multimodal Neuroimaging Techniques to in vivo Address Compensatory and Disintegration Patterns in Neurodegenerative Disorders: Evidence from Cortico-Cerebellar Connections in Multiple Sclerosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Efstratios%20Karavasilis">Efstratios Karavasilis</a>, <a href="https://publications.waset.org/abstracts/search?q=Foteini%20Christidi"> Foteini Christidi</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgios%20Velonakis"> Georgios Velonakis</a>, <a href="https://publications.waset.org/abstracts/search?q=Agapi%20Plousi"> Agapi Plousi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kalliopi%20Platoni"> Kalliopi Platoni</a>, <a href="https://publications.waset.org/abstracts/search?q=Nikolaos%20Kelekis"> Nikolaos Kelekis</a>, <a href="https://publications.waset.org/abstracts/search?q=Ioannis%20Evdokimidis"> Ioannis Evdokimidis</a>, <a href="https://publications.waset.org/abstracts/search?q=Efstathios%20Efstathopoulos"> Efstathios Efstathopoulos</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Advanced structural and functional neuroimaging techniques contribute to the study of anatomical and functional brain connectivity and its role in the pathophysiology and symptoms’ heterogeneity in several neurodegenerative disorders, including multiple sclerosis (MS). Aim: In the present study, we applied multiparametric neuroimaging techniques to investigate the structural and functional cortico-cerebellar changes in MS patients. Material: We included 51 MS patients (28 with clinically isolated syndrome [CIS], 31 with relapsing-remitting MS [RRMS]) and 51 age- and gender-matched healthy controls (HC) who underwent MRI in a 3.0T MRI scanner. Methodology: The acquisition protocol included high-resolution 3D T1 weighted, diffusion-weighted imaging and echo planar imaging sequences for the analysis of volumetric, tractography and functional resting state data, respectively. We performed between-group comparisons (CIS, RRMS, HC) using CAT12 and CONN16 MATLAB toolboxes for the analysis of volumetric (cerebellar gray matter density) and functional (cortico-cerebellar resting-state functional connectivity) data, respectively. Brainance suite was used for the analysis of tractography data (cortico-cerebellar white matter integrity; fractional anisotropy [FA]; axial and radial diffusivity [AD; RD]) to reconstruct the cerebellum tracts. Results: Patients with CIS did not show significant gray matter (GM) density differences compared with HC. However, they showed decreased FA and increased diffusivity measures in cortico-cerebellar tracts, and increased cortico-cerebellar functional connectivity. Patients with RRMS showed decreased GM density in cerebellar regions, decreased FA and increased diffusivity measures in cortico-cerebellar WM tracts, as well as a pattern of increased and mostly decreased functional cortico-cerebellar connectivity compared to HC. The comparison between CIS and RRMS patients revealed significant GM density difference, reduced FA and increased diffusivity measures in WM cortico-cerebellar tracts and increased/decreased functional connectivity. The identification of decreased WM integrity and increased functional cortico-cerebellar connectivity without GM changes in CIS and the pattern of decreased GM density decreased WM integrity and mostly decreased functional connectivity in RRMS patients emphasizes the role of compensatory mechanisms in early disease stages and the disintegration of structural and functional networks with disease progression. Conclusions: In conclusion, our study highlights the added value of multimodal neuroimaging techniques for the in vivo investigation of cortico-cerebellar brain changes in neurodegenerative disorders. An extension and future opportunity to leverage multimodal neuroimaging data inevitably remain the integration of such data in the recently-applied mathematical approaches of machine learning algorithms to more accurately classify and predict patients’ disease course. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=advanced%20neuroimaging%20techniques" title="advanced neuroimaging techniques">advanced neuroimaging techniques</a>, <a href="https://publications.waset.org/abstracts/search?q=cerebellum" title=" cerebellum"> cerebellum</a>, <a href="https://publications.waset.org/abstracts/search?q=MRI" title=" MRI"> MRI</a>, <a href="https://publications.waset.org/abstracts/search?q=multiple%20sclerosis" title=" multiple sclerosis"> multiple sclerosis</a> </p> <a href="https://publications.waset.org/abstracts/89592/leveraging-multimodal-neuroimaging-techniques-to-in-vivo-address-compensatory-and-disintegration-patterns-in-neurodegenerative-disorders-evidence-from-cortico-cerebellar-connections-in-multiple-sclerosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89592.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">140</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Pregnancy Outcomes in Patients With Inflammatory Bowel Disease: Retrospective Data From a Greek National Registry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Evgenia%20Papathanasiou">Evgenia Papathanasiou</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgios%20Kokkotis"> Georgios Kokkotis</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgios%20Axiaris"> Georgios Axiaris</a>, <a href="https://publications.waset.org/abstracts/search?q=Theodoros%20Argyropoulos"> Theodoros Argyropoulos</a>, <a href="https://publications.waset.org/abstracts/search?q=Nikos%20Viazis"> Nikos Viazis</a>, <a href="https://publications.waset.org/abstracts/search?q=Olga%20Giouleme"> Olga Giouleme</a>, <a href="https://publications.waset.org/abstracts/search?q=Konstantinos%20Gkoumas"> Konstantinos Gkoumas</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%91nthia%20Gatopoulou"> Αnthia Gatopoulou</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%91ggelos%20Theodoulou"> Αggelos Theodoulou</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgios%20Theocharis"> Georgios Theocharis</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%91ngeliki%20Theodoropoulou"> Αngeliki Theodoropoulou</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%9Caria%20%CE%9Aalogirou"> Μaria Κalogirou</a>, <a href="https://publications.waset.org/abstracts/search?q=Pantelis%20Karatzas"> Pantelis Karatzas</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%9Aonstantinos%20%CE%9Aatsanos"> Κonstantinos Κatsanos</a>, <a href="https://publications.waset.org/abstracts/search?q=Theodora%20Kafetzi"> Theodora Kafetzi</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%9Aonstantinos%20%CE%9Aarmiris"> Κonstantinos Κarmiris</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%91nastasia%20%CE%9Aourikou"> Αnastasia Κourikou</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%99oannis%20E%20%CE%9Aoutroubakis"> Ιoannis E Κoutroubakis</a>, <a href="https://publications.waset.org/abstracts/search?q=Christos%20Liatsos"> Christos Liatsos</a>, <a href="https://publications.waset.org/abstracts/search?q=Gerassimos%20J.%20Mantzaris"> Gerassimos J. Mantzaris</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%9Dicoletta%20%CE%9Cathou"> Νicoletta Μathou</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgia%20Bellou"> Georgia Bellou</a>, <a href="https://publications.waset.org/abstracts/search?q=George%20Michalopoulos%20%CE%91ikaterini%20%CE%9Cantaka"> George Michalopoulos Αikaterini Μantaka</a>, <a href="https://publications.waset.org/abstracts/search?q=Penelope%20Nikolaou"> Penelope Nikolaou</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%9Cichael%20Oikonomou"> Μichael Oikonomou</a>, <a href="https://publications.waset.org/abstracts/search?q=Dimitrios%20Polymeros"> Dimitrios Polymeros</a>, <a href="https://publications.waset.org/abstracts/search?q=George%20Papatheodoridis"> George Papatheodoridis</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%95vdoxia%20Stergiou"> Εvdoxia Stergiou</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%9Aonstantinos%20Soufleris"> Κonstantinos Soufleris</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%95pameinondas%20Skouloudis"> Εpameinondas Skouloudis</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%9Caria%20Tzouvala"> Μaria Tzouvala</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgia%20Tsiolakidou"> Georgia Tsiolakidou</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%95ftychia%20Tsironi"> Εftychia Tsironi</a>, <a href="https://publications.waset.org/abstracts/search?q=Styliani%20Tsafaraki"> Styliani Tsafaraki</a>, <a href="https://publications.waset.org/abstracts/search?q=Kalliopi%20Foteinogiannopoulou"> Kalliopi Foteinogiannopoulou</a>, <a href="https://publications.waset.org/abstracts/search?q=Konstantina%20Chalakatevaki"> Konstantina Chalakatevaki</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%91ngeliki%20Christidou"> Αngeliki Christidou</a>, <a href="https://publications.waset.org/abstracts/search?q=Dimitrios%20K.%20Christodoulou"> Dimitrios K. Christodoulou</a>, <a href="https://publications.waset.org/abstracts/search?q=Giorgos%20Bamias"> Giorgos Bamias</a>, <a href="https://publications.waset.org/abstracts/search?q=Spyridon%20Michopoulos"> Spyridon Michopoulos</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%95vanthia%20Zampeli"> Εvanthia Zampeli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Inflammatory bowel disease (IBD) commonly affects female patients of reproductive age, making the interaction between fertility, pregnancy and IBD an important issue in disease management. The effect of disease activity on the outcome of pregnancy and its impact on neonatal growth is a field of intense research. Close follow-up of pregnant IBD patients by a multidisciplinary team improves maternal and neonatal outcomes. Aim – Methods: Α national retrospective study of pregnancies in women with IBD between 2010-2020 was carried out in 22 IBD reference centers in Greece. Patient characteristics such as disease profile, type of treatment, and disease activity during gestation were analyzed in correlation to the method of delivery, pregnancy outcomes, as well as breastfeeding and offspring health. Results: Two-hundred and twenty-three pregnancies in 175 IBD patients were registered in the study. 122 with Crohn’s disease (CD). Median age during diagnosis was 25.6 years (12-44), with median disease duration of 7.4 years (0-23). One-hundred and twenty-nine patients (58%) were recorded during their first pregnancy. Early pregnancy termination was reported by 48 patients (22%). Pregnancy as a result of in vitro fertilization (IVF) occurred in 15 cases (6.7%). At the beginning of gestation, 165 patients (74%) were under treatment: 48 with anti-TNF agents (29%), 43 with azathioprine (26%), 101 with 5-aminosalicylic acid formulations (61%) and 12 with steroids (7%). We recorded 49 cases of IBD flares (22%) during pregnancy. Two-thirds of them (n=30) were in remission at the onset of the pregnancy. Almost half of them (n=22) required corticosteroid treatment. Patients with ulcerative colitis (UC) were in greater risk of disease flare during pregnancy (p<0.001). All but 3 pregnancies (99.1%) resulted in uncomplicated delivery. In 147 cases (67.1%), cesarean delivery was performed. Two late fetal deaths (0.9%) were reported, both in patients with continuously active disease since the beginning of pregnancy. After delivery, 75 patients (34%) presented with a disease flare, which was associated with active disease at the beginning of pregnancy (p <0.001). Conclusion: The majority of female, Greek IBD patients, had a favorable pregnancy outcome. Active inflammation during gestation and UC diagnosis were associated with a negative impact on pregnancy outcomes. The results of this study are in favor of the continuation of IBD treatment during pregnancy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pregnancy" title="pregnancy">pregnancy</a>, <a href="https://publications.waset.org/abstracts/search?q=ulcerative%20colitis" title=" ulcerative colitis"> ulcerative colitis</a>, <a href="https://publications.waset.org/abstracts/search?q=Crohn%20disease" title=" Crohn disease"> Crohn disease</a>, <a href="https://publications.waset.org/abstracts/search?q=flare" title=" flare"> flare</a> </p> <a href="https://publications.waset.org/abstracts/166205/pregnancy-outcomes-in-patients-with-inflammatory-bowel-disease-retrospective-data-from-a-greek-national-registry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166205.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">87</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>