{"title":"Vitamin D Deficiency and Insufficiency in Postmenopausal Women with Obesity","authors":"Vladyslav Povoroznyuk, Anna Musiienko, Nataliia Dzerovych, Roksolana Povoroznyuk, Oksana Ivanyk","volume":137,"journal":"International Journal of Medical and Health Sciences","pagesStart":192,"pagesEnd":196,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/10008941","abstract":"<p>Deficiency and insufficiency of Vitamin D is a pandemic of the 21<sup>st<\/sup> century. Obesity patients have a lower level of vitamin D, but the literature data are contradictory. The purpose of this study is to investigate deficiency and insufficiency vitamin D in postmenopausal women with obesity. We examined 1007 women aged 50-89 years. Mean age was 65.74&plusmn;8.61 years; mean height was 1.61&plusmn;0.07 m; mean weight was 70.65&plusmn;13.50 kg; mean body mass index was 27.27&plusmn;4.86 kg\/m<sup>2<\/sup>, and mean 25(OH) D levels in serum was 26.00&plusmn;12.00 nmol\/l. The women were divided into the following six groups depending on body mass index: I group &ndash; 338 women with normal body weight, II group &ndash; 16 women with insufficient body weight, III group &ndash; 382 women with excessive body weight, IV group &ndash; 199 women with obesity of class I, V group &ndash; 60 women with obesity of class II, and VI group &ndash; 12 women with obesity of class III. Level of 25(OH)D in serum was measured by means of an electrochemiluminescent method - Elecsys 2010 analyzer (Roche Diagnostics, Germany) and cobas test-systems. 34.4% of the examined women have deficiency of vitamin D and 31.4% insufficiency. Women with obesity of class I (23.60&plusmn;10.24 ng\/ml) and obese of class II (22.38&plusmn;10.34 ng\/ml) had significantly lower levels of 25 (OH) D compared to women with normal body weight (28.24&plusmn;12.99 ng\/ml), p=0.00003. In women with obesity, BMI significantly influences vitamin D level, and this influence does not depend on the season.<\/p>\r\n","references":"[1]\tN. M. Al-Daghri, F. R. Guerini, O. S. Al-Attas, M. S. Alokail \u201cVitamin D Receptor Gene Polymorphisms Are Associated with Obesity and Inflammosome Activity,\u201d PLoS One. July 14, 2014. https:\/\/doi.org\/10.1371\/journal.pone.0102141.\r\n[2]\t L. Gonzalez; G. Ramos-Trautmann; G. M. Diaz-Luquis; C. M. Perez; C. Palacios \u201cVitamin D status is inversely associated with obesity in a clinic-based sample in Puerto Rico,\u201d Nutr. Res. 2015, vol. 35, pp. 287\u2013293.\r\n[3]\tM. Pereira-Santos; P. R. Costa; A. M. Assis; C. A. Santos; D. B. Santos \u201cObesity and vitamin D deficiency: A systematic review and meta-analysis,\u201d Obes. Rev. 2015, vol. 16, pp. 341\u2013349.\r\n[4]\tV. Rontoyann, J. Avila, S. Kaul \u201cAssociation between Obesity and Serum 25(OH)D Concentrations in Older Mexican Adults,\u201d Nutrients, 2017, vol. 9, pp. 92-97.\r\n[5]\tL. Samuel; L. N. Borrell \u201cThe effect of body mass index on adequacy of serum 25-hydroxyvitamin D levels in US adults: The National Health and Nutrition Examination Survey 2001 to 2006,\u201d Ann. Epidemiol. 2014, vol. 24, pp. 781\u2013784.\r\n[6]\t S. Soskic; E. Stokic, E. R. Isenovic \u201cThe relationship between vitamin D and obesity,\u201d Curr. Med. Res. Opin. 2014, vol. 30, pp. 1197\u20131199.\r\n[7]\tNutrition, Physical Activity and Obesity\/\/Available online: http:\/\/www.euro.who.int\/ru\/health-topics\/disease-prevention\/nutrition\/\r\ncountry-work\/ukraine2.\r\n[8]\tV. V. Povoroznyuk, N. I. Balatska, V. Y. Muts, F. V. Klymovytsky, O. V. Synenky \u201cVitamin D deficiency in Ukraine: A demographic and seasonal analysis,\u201d Gerontologija 2012, vol. 13(4), pp. 191\u2013198.\r\n[9]\tV. Povoroznyuk, P. Pludowski. Defitsyt i nedostatnist\u02b9 vitaminu D: epidemiolohiya, diahnostyka, profilaktyka ta likuvannya (Vitamin D deficiency and deficiency: epidemiology, diagnosis, prevention and treatment), Donetsk, 2014. 262 p. (In Ukrainian).\r\n[10]\tM. F. Holick, N. C. Binkley, H. A. Bischoff-Ferrari, et al. \u201cEvaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline,\u201d J Clin Endocrinol Metab. 2011, vol. 96(7), pp. 1911-193. DOI: 10.1210\/jc.2011-0385.","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 137, 2018"}