Search results for: Macrovipera lebetina obtusa

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lebetina obtusa</title> <meta name="description" content="Search results for: Macrovipera lebetina obtusa"> <meta name="keywords" content="Macrovipera lebetina obtusa"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Macrovipera lebetina obtusa"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 4</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Macrovipera lebetina obtusa</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Anti-Angiogenic Effects of the Macrovipera lebetina obtusa Snake Crude Venom and Obtustatin</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Narine%20Ghazaryan">Narine Ghazaryan</a>, <a href="https://publications.waset.org/abstracts/search?q=Joana%20Catarina%20Macedo"> Joana Catarina Macedo</a>, <a href="https://publications.waset.org/abstracts/search?q=Sara%20Vaz"> Sara Vaz</a>, <a href="https://publications.waset.org/abstracts/search?q=Naira%20Ayvazyan"> Naira Ayvazyan</a>, <a href="https://publications.waset.org/abstracts/search?q=Elsa%20Logarinho"> Elsa Logarinho</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Macrovipera lebetina obtusa (MLO) is a poisonous snake in Armenia. Obtustatin represents the shortest known monomeric disintegrin, isolated from the snake venom of MLO, and is known to specifically inhibit α1β1 integrin. Its oncostatic effect is due to the inhibition of angiogenesis, which likely arises from α1β1 integrin inhibition in the endothelial cells. To explore the therapeutic potential of the MLO snake venom and obtustatin, we studied activity of obtustatin and MLO venom in vitro, by testing their efficacy in human dermal microvascular endothelial cells (HMVEC-D) and in vivo, using chick embryo chorioallantoic membrane assay (CAM assay). Our in vitro results showed that obtustatin in comparison with MLO venom did not exhibit cytotoxic activity in HMVEC-D cells in comparison to MLO venom. But in vivo results have shown that 4µg /embryo (90 µM) of obtustatin inhibited angiogenesis induced by FGF2 by 17% while MLO snake venom induced 22% reduction of the angiogenic index. The concentration of obtustatin in the crude MLO venom was 0.3 nM, which is 300.000 times less than the concentration of the obtustatin itself. Given this enormous difference in concentration, it is likely that some components of the crude venom contribute to the observed anti-angiogenic effect. Hypotheses will be ascertained to justify this action: components in the MLO venom may increase obtustatin efficacy or have independent but synergic anti-angiogenic activities. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=angiogenesis" title="angiogenesis">angiogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=alpa1%20beta%201%20integrin" title=" alpa1 beta 1 integrin"> alpa1 beta 1 integrin</a>, <a href="https://publications.waset.org/abstracts/search?q=Macrovipera%20lebetina%20obtusa" title=" Macrovipera lebetina obtusa"> Macrovipera lebetina obtusa</a>, <a href="https://publications.waset.org/abstracts/search?q=obtustatin" title=" obtustatin"> obtustatin</a> </p> <a href="https://publications.waset.org/abstracts/85110/anti-angiogenic-effects-of-the-macrovipera-lebetina-obtusa-snake-crude-venom-and-obtustatin" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85110.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">196</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Bioactive Rare Acetogenins from the Red Alga Laurencia obtusa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20A.%20Ghandourah">Mohamed A. Ghandourah</a>, <a href="https://publications.waset.org/abstracts/search?q=Walied%20M.%20Alarif"> Walied M. Alarif</a>, <a href="https://publications.waset.org/abstracts/search?q=Nahed%20O.%20Bawakid"> Nahed O. Bawakid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Halogenated cyclic enynes and terpenoids are commonly identified among secondary metabolites of the genus Laurencia. Laurencian acetogenins are entirly C15 non-terpenoid haloethers with different carbocyclic nuclei; a specimen of the Red Sea red alga L. obtusa was investigated for its acetogenin content. The dichloromethane extract of the air-dried red algal material was fractionated on aluminum oxide column preparative thin-layer chromatography. Three new rare C12 acetogenin derivatives (1-3) were isolated from the organic extract obtained from Laurencia obtusa, collected from the territorial Red Sea water of Saudi Arabia. The structures of the isolated metabolites were established by means of spectroscopical data analyses. Examining the isolated compounds in activated human peripheral blood mononuclear cells (PBMC) revealed potent Anti-inflammatory activity as evidenced by inhibition of NFκB and release of other inflammatory mediators like TNF-α, IL-1β and IL-6. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Red%20Sea" title="Red Sea">Red Sea</a>, <a href="https://publications.waset.org/abstracts/search?q=red%20algae" title=" red algae"> red algae</a>, <a href="https://publications.waset.org/abstracts/search?q=fatty%20acids" title=" fatty acids"> fatty acids</a>, <a href="https://publications.waset.org/abstracts/search?q=spectroscopy" title=" spectroscopy"> spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-inflammatory" title=" anti-inflammatory"> anti-inflammatory</a> </p> <a href="https://publications.waset.org/abstracts/85016/bioactive-rare-acetogenins-from-the-red-alga-laurencia-obtusa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85016.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">149</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Isolation of New C₁₅ Acetogenins from the Red Alga Laurencia obtusa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nahed%20O.%20Bawakid">Nahed O. Bawakid</a>, <a href="https://publications.waset.org/abstracts/search?q=Walied%20M.%20Alarif"> Walied M. Alarif</a> </p> <p class="card-text"><strong>Abstract:</strong></p> With regard to the uniqueness of the red algae of the genus Laurencia as the source of C₁₅-acetogenins, along with the diversity of biological applications; the acetogenin content of the Red Sea L. obtusa was investigated. Fractionation and purification of the CH₂Cl₂/MeOH extract were done by applying several chromatographic techniques, including column and preparative thin-layer chromatography; followed by a series of ¹H nuclear magnetic resonance measurements to give rise of some interesting notes. A new rare chloroallene-based C₁₅ acetogenin, laurentusenin (1) along with a new furan ring containing C₁₅ acetogenin, laurenfuresenin (2), were isolated from the red alga L. obtusa. Comparing 1D and 2D NMR, MS, UV and IR spectral data for the new isolated compounds with the reported bromoallene containing acetogenins spectral data was played the crucial role for characterization of their hemical structures. The apoptosis induced by these two compounds was demonstrated by DNA fragmentation assay and microscopic observation. These observations suggest that (1) and (2) may be involved in regulation of programmed death in the initiation and propagation of inflammatory responses. The isolated metabolite (1) showed unusual substituted allene side chain, while (2) inserted furan ring as a new acetogenin nucleus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cyclic%20enyne" title="cyclic enyne">cyclic enyne</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-inflammatory" title=" anti-inflammatory"> anti-inflammatory</a>, <a href="https://publications.waset.org/abstracts/search?q=fatty%20acids" title=" fatty acids"> fatty acids</a>, <a href="https://publications.waset.org/abstracts/search?q=marine%20algae" title=" marine algae"> marine algae</a>, <a href="https://publications.waset.org/abstracts/search?q=halogenations" title=" halogenations"> halogenations</a> </p> <a href="https://publications.waset.org/abstracts/84933/isolation-of-new-c15-acetogenins-from-the-red-alga-laurencia-obtusa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84933.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">151</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Protective Effect of Essential Oil from Chamaecyparis obtusa on Anxiety-Related Behaviors and Cytokine Abnormalities Induced by Early Life Stress</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hae%20Jeong%20Park">Hae Jeong Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Joo-Ho%20Chung"> Joo-Ho Chung</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, the effect of essential oil from Chamaecyparis obtuse (EOCO) on early life stress using maternal separation (MS) rats was investigated. Anxiety-related behaviors were examined in MS rats using the elevated plus-maze (EPM) test. The changes of gene expressions by EOCO in the hippocampus of MS rats were analyzed using a microarray method. Rats in the MS groups were separated from their respective mothers from postnatal day (pnd) 14 to 28. Rats in the EOCO-treated groups were exposed to EOCO for 1 h or 2 h by inhalation from pnd 21 to 28. The EOCO-treated MS rats showed decreased anxiety-related behaviors compared to the MS rats in the EPM test. In the microarray analysis, EOCO downregulated the expressions of cytokine genes such as Ccl2, Il6, Cxcl10, Ccl19, and Il1rl in the hippocampus of MS rats, and it was also confirmed through RT-PCR. In particular, the expressions of Ccl2 and Il6 were predominantly decreased by EOCO in the hippocampus of MS rats. Interestingly, their protein expressions were also reduced by EOCO in MS rats. These results indicate that EOCO decreases MS-induced anxiety-related behaviors, and modulate cytokines, particularly Ccl2 and Il6, in the hippocampus of MS rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anxiety-related%20behavior" title="anxiety-related behavior">anxiety-related behavior</a>, <a href="https://publications.waset.org/abstracts/search?q=Chamaecyparis%20obtuse" title=" Chamaecyparis obtuse"> Chamaecyparis obtuse</a>, <a href="https://publications.waset.org/abstracts/search?q=cytokine%20gene" title=" cytokine gene"> cytokine gene</a>, <a href="https://publications.waset.org/abstracts/search?q=early-life%20stress" title=" early-life stress"> early-life stress</a>, <a href="https://publications.waset.org/abstracts/search?q=maternal%20separation" title=" maternal separation"> maternal separation</a> </p> <a href="https://publications.waset.org/abstracts/52686/protective-effect-of-essential-oil-from-chamaecyparis-obtusa-on-anxiety-related-behaviors-and-cytokine-abnormalities-induced-by-early-life-stress" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52686.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">389</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates 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Search results for: Macrovipera lebetina obtusa