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Ahmad Chaudhry"</a> – <a rel="nofollow" class="external text" href="https://www.google.com/search?tbm=nws&q=%22M.+Ahmad+Chaudhry%22+-wikipedia&tbs=ar:1">news</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?&q=%22M.+Ahmad+Chaudhry%22&tbs=bkt:s&tbm=bks">newspapers</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?tbs=bks:1&q=%22M.+Ahmad+Chaudhry%22+-wikipedia">books</a> <b>·</b> <a rel="nofollow" class="external text" href="https://scholar.google.com/scholar?q=%22M.+Ahmad+Chaudhry%22">scholar</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.jstor.org/action/doBasicSearch?Query=%22M.+Ahmad+Chaudhry%22&acc=on&wc=on">JSTOR</a></span></small></span> <span class="date-container"><i>(<span class="date">April 2011</span>)</i></span><span class="hide-when-compact"><i> (<small><a href="/wiki/Help:Maintenance_template_removal" title="Help:Maintenance template removal">Learn how and when to remove this message</a></small>)</i></span></div></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1251242444"><table class="box-BLP_sources plainlinks metadata ambox ambox-content ambox-BLP_sources" role="presentation"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><span typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/40px-Ambox_important.svg.png" decoding="async" width="40" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/60px-Ambox_important.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/80px-Ambox_important.svg.png 2x" data-file-width="40" data-file-height="40" /></span></span></div></td><td class="mbox-text"><div class="mbox-text-span">This <a href="/wiki/Wikipedia:Biographies_of_living_persons" title="Wikipedia:Biographies of living persons">biography of a living person</a> <b>needs additional <a href="/wiki/Wikipedia:Citing_sources" title="Wikipedia:Citing sources">citations</a> for <a href="/wiki/Wikipedia:Verifiability" title="Wikipedia:Verifiability">verification</a></b>.<span class="hide-when-compact"> Please help by adding <a href="/wiki/Wikipedia:Reliable_sources" title="Wikipedia:Reliable sources">reliable sources</a>. <a href="/wiki/Wikipedia:Biographies_of_living_persons#Remove_contentious_material_that_is_unsourced_or_poorly_sourced" title="Wikipedia:Biographies of living persons">Contentious material</a> about living persons that is unsourced or <a href="/wiki/Wikipedia:Reliable_sources#Questionable_and_self-published_sources" title="Wikipedia:Reliable sources">poorly sourced</a> <b>must be removed immediately</b> from the article and its talk page, especially if potentially <a href="/wiki/Wikipedia:Libel" title="Wikipedia:Libel">libelous</a>.<br /><small><span class="plainlinks"><i>Find sources:</i> <a rel="nofollow" class="external text" href="https://www.google.com/search?as_eq=wikipedia&q=%22M.+Ahmad+Chaudhry%22">"M. Ahmad Chaudhry"</a> – <a rel="nofollow" class="external text" href="https://www.google.com/search?tbm=nws&q=%22M.+Ahmad+Chaudhry%22+-wikipedia&tbs=ar:1">news</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?&q=%22M.+Ahmad+Chaudhry%22&tbs=bkt:s&tbm=bks">newspapers</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?tbs=bks:1&q=%22M.+Ahmad+Chaudhry%22+-wikipedia">books</a> <b>·</b> <a rel="nofollow" class="external text" href="https://scholar.google.com/scholar?q=%22M.+Ahmad+Chaudhry%22">scholar</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.jstor.org/action/doBasicSearch?Query=%22M.+Ahmad+Chaudhry%22&acc=on&wc=on">JSTOR</a></span></small></span> <span class="date-container"><i>(<span class="date">September 2022</span>)</i></span><span class="hide-when-compact"><i> (<small><a href="/wiki/Help:Maintenance_template_removal" title="Help:Maintenance template removal">Learn how and when to remove this message</a></small>)</i></span></div></td></tr></tbody></table> </div> </div><span class="hide-when-compact"><i> (<small><a href="/wiki/Help:Maintenance_template_removal" title="Help:Maintenance template removal">Learn how and when to remove this message</a></small>)</i></span></div></td></tr></tbody></table> <p><b>M. Ahmad Chaudhry</b> is an American <a href="/wiki/Radiologist" class="mw-redirect" title="Radiologist">radiologist</a>, Associate Professor at the <a href="/wiki/University_of_Vermont" title="University of Vermont">University of Vermont</a>, and Interim Associate Dean for Research, in the College of Nursing and Health Sciences.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>He received a Ph.D. degree in <a href="/wiki/Molecular_biology" title="Molecular biology">molecular biology</a> from the <a href="/wiki/University_of_Manchester" title="University of Manchester">University of Manchester</a>, <a href="/wiki/United_Kingdom" title="United Kingdom">UK</a>. He did <a href="/wiki/Postdoctoral_research" class="mw-redirect" title="Postdoctoral research">postdoctoral research</a> work at the <a href="/wiki/University_of_Alberta" title="University of Alberta">University of Alberta</a> in <a href="/wiki/Canada" title="Canada">Canada</a>, before joining the <a href="/wiki/University_of_Pennsylvania" title="University of Pennsylvania">University of Pennsylvania</a> as a Senior Research Investigator. His research interests are <a href="/wiki/Micro-RNA" class="mw-redirect" title="Micro-RNA">micro-RNA</a> responses to <a href="/wiki/Ionizing_radiation" title="Ionizing radiation">radiation exposure</a>, <a href="/wiki/Bystander_effect_(radiobiology)" title="Bystander effect (radiobiology)">radiation-induced bystander effect</a>, <a href="/wiki/Cell_cycle" title="Cell cycle">cell cycle</a> perturbations and the enzymatic processing of clustered DNA damage. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Education">Education</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M._Ahmad_Chaudhry&action=edit&section=1" title="Edit section: Education"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>He received his M.Sc. from University of Manchester, UK, Molecular Biology, 1987 and his Ph.D., University of Manchester, UK, Molecular Biology, 1990. </p> <div class="mw-heading mw-heading2"><h2 id="The_role_of_micro-RNA_in_the_cellular_response_to_radiation_treatment">The role of micro-RNA in the cellular response to radiation treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M._Ahmad_Chaudhry&action=edit&section=2" title="Edit section: The role of micro-RNA in the cellular response to radiation treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Ionizing_radiation" title="Ionizing radiation">Ionizing radiation</a> interferes with cellular functions at all levels of <a href="/wiki/Cell_(biology)#Anatomy" title="Cell (biology)">cell organization</a>. The ionizing radiation-induced <a href="/wiki/Stress_response" class="mw-redirect" title="Stress response">stress response</a> is very complex and involves many <a href="/wiki/Cellular_process" class="mw-redirect" title="Cellular process">cellular processes</a>. Dr. Chaudry is investigating the involvement of small non-coding micro-RNA in the response of human cells exposed to ionizing radiation. Micro RNAs (miRNAs) are small non-protein-coding single-stranded <a href="/wiki/RNA" title="RNA">RNAs</a> of ~22 <a href="/wiki/Nucleotide" title="Nucleotide">nucleotides</a> that function as negative <a href="/wiki/Gene_regulation" class="mw-redirect" title="Gene regulation">gene regulators</a>. miRNA negatively regulate their targets either by binding with perfect or nearly perfect complementarity to protein coding mRNA sequences to induce the RNA-mediated interference (RNAi) pathway. Most miRNAs do not cleave their mRNA targets as a mechanism of gene regulation. These miRNAs bind to imperfect complementary sites within the 3′ <a href="/wiki/Untranslated_Region" class="mw-redirect" title="Untranslated Region">untranslated regions</a> (UTRs) of their mRNA targets. In this case the target-<a href="/wiki/Gene_repression" class="mw-redirect" title="Gene repression">gene repression</a> occurs post-transcriptionally at the level of <a href="/wiki/Translation_(biology)" title="Translation (biology)">translation</a> resulting in reduced protein levels but the mRNA levels remain unaffected. A single miRNA has the capability to bind to as many as 200 diverse gene targets ranging from <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factors</a>, secreted factors, <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptors</a> and transporters, thus potentially controlling the expression of about one-third of human mRNAs. Research has identified cell type specific modulation of several miRNA in <a href="/wiki/Gamma_radiation" class="mw-redirect" title="Gamma radiation">gamma radiation</a> and <a href="/wiki/X-ray" title="X-ray">X-ray</a>-treated human cells. Other studies from our laboratory showed that the expression of many miRNA markedly differ within the same <a href="/wiki/Cell_line" class="mw-redirect" title="Cell line">cell line</a> after exposure to either low or high doses of <a href="/wiki/Radiation" title="Radiation">radiation</a>. His work also identified radiation-induced modulation of miRNA in cells with altered DNA repair capability. These studies have provided evidence that miRNA are involved in the response to ionizing radiation exposure in human cells. </p> <div class="mw-heading mw-heading2"><h2 id="Selected_publications">Selected publications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M._Ahmad_Chaudhry&action=edit&section=3" title="Edit section: Selected publications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Chaudhry, M. A., Kreger, B. and Omaruddin, R. A. (2010). Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity. <i>International Journal of Radiation Biology.</i> 86: 569-583.</li> <li>Chaudhry, M. A., Sachdeva, H. and Omaruddin, R. A. (2010). Radiation-induced micro-RNA modulation in glioblastoma cells differing in DNA-repair pathways. <i>DNA and Cell Biology.</i> 29: 553-561.</li> <li>Omaruddin, R. A. and Chaudhry, M.A. (2010). Detection of genomic DNA methylation with Denaturing High-Performance Liquid Chromatography. <i>Human Cell.</i> 23: 41-49. (Abstract)</li> <li>Chaudhry, M.A. (2009). Real-time PCR analysis of Micro-RNA expression in ionizing radiation treated cells. <i>Cancer Biotherapy & Radiopharmaceuticals.</i> 24: 49-56</li> <li>Chaudhry, M.A. (2008). Analysis of gene expression in normal and cancer cells exposed to g-radiation. J Biomed. Biotech. 2008: 541678.</li> <li>Chaudhry, M.A.(2008). Biomarkers for human radiation exposure. <i>J Biomed Sci.</i> 15: 557-563.</li> <li>Chaudhry, M.A. (2007). Base excision repair of ionizing radiation-induced DNA damage in G1 and G2 cell cycle phases. <i>Cancer Cell Int.</i> 7:15.</li> <li>Yang, N., Chaudhry, M.A., Wallace, S. S. (2006). Base Excision Repair by hNTH1 and hOGG1: A Two Edged Sword in the Processing of DNA Damage in g-irradiated Human Cells. <i>DNA Repair</i> 5: 43-51.</li> <li>Chaudhry, M.A.(2006). Bystander effect: Biological endpoints and microarray analysis. <i>Mutation Research</i> 597:98-112.</li> <li>Chaudhry, M.A.(2006). "An exercise to estimate differential gene expression in human cells". <i>Biochem Mol Biol Edu</i> 34: 116-120.</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=M._Ahmad_Chaudhry&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20121013045350/http://www.uvm.edu/~cnhs/?Page=faculty/chaudhry.html">"College of Nursing and Health Sciences : University of Vermont"</a>. 2012-10-13. Archived from <a rel="nofollow" class="external text" href="http://www.uvm.edu/~cnhs/?Page=faculty/chaudhry.html">the original</a> on 13 October 2012<span class="reference-accessdate">. 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