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Liu</title> <meta name="description" content="Search results for: Jianhua Liu"> <meta name="keywords" content="Jianhua Liu"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Jianhua Liu"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 17</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Jianhua Liu</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> Extracting Attributes for Twitter Hashtag Communities</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ashwaq%20Alsulami">Ashwaq Alsulami</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Shao"> Jianhua Shao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Various organisations often need to understand discussions on social media, such as what trending topics are and characteristics of the people engaged in the discussion. A number of approaches have been proposed to extract attributes that would characterise a discussion group. However, these approaches are largely based on supervised learning, and as such they require a large amount of labelled data. We propose an approach in this paper that does not require labelled data, but rely on lexical sources to detect meaningful attributes for online discussion groups. Our findings show an acceptable level of accuracy in detecting attributes for Twitter discussion groups. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=attributed%20community" title="attributed community">attributed community</a>, <a href="https://publications.waset.org/abstracts/search?q=attribute%20detection" title=" attribute detection"> attribute detection</a>, <a href="https://publications.waset.org/abstracts/search?q=community" title=" community"> community</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20network" title=" social network"> social network</a> </p> <a href="https://publications.waset.org/abstracts/142851/extracting-attributes-for-twitter-hashtag-communities" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142851.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">162</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Novel Stator Structure Switching Flux Permanent Magnet Motor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mengjie%20Shen">Mengjie Shen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Wu"> Jianhua Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=Chun%20Gan"> Chun Gan</a>, <a href="https://publications.waset.org/abstracts/search?q=Lifeng%20Zhang"> Lifeng Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Qingguo%20Sun"> Qingguo Sun</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Switching flux permanent magnet (SFPM) motor has doubly salient structure which lead to high torque ripple, and also has cogging torque as a permanent magnet motor. Torque ripple and cogging torque have impact on the motor performance. A novel stator structure SFPM motor is presented in this paper. A triangular shape silicon steel sheet is put in the stator slot to reduce the torque ripple, which will not deteriorate the cogging torque. The simulation of proposed motor is analyzed using 2-D finite element method (FEM) based on Ansoft and Simplorer software, and the result show a good performance of the proposed SFPM motor. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=switching%20flux%20permanent%20magnet%20%28SFPM%29%20motor" title="switching flux permanent magnet (SFPM) motor">switching flux permanent magnet (SFPM) motor</a>, <a href="https://publications.waset.org/abstracts/search?q=torque%20ripple" title=" torque ripple"> torque ripple</a>, <a href="https://publications.waset.org/abstracts/search?q=Ansoft" title=" Ansoft"> Ansoft</a>, <a href="https://publications.waset.org/abstracts/search?q=FEM" title=" FEM"> FEM</a> </p> <a href="https://publications.waset.org/abstracts/20010/novel-stator-structure-switching-flux-permanent-magnet-motor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20010.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">570</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> On the Framework of Contemporary Intelligent Mathematics Underpinning Intelligent Science, Autonomous AI, and Cognitive Computers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yingxu%20Wang">Yingxu Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Lu"> Jianhua Lu</a>, <a href="https://publications.waset.org/abstracts/search?q=Jun%20Peng"> Jun Peng</a>, <a href="https://publications.waset.org/abstracts/search?q=Jiawei%20Zhang"> Jiawei Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The fundamental demand in contemporary intelligent science towards Autonomous AI (AI*) is the creation of unprecedented formal means of Intelligent Mathematics (IM). It is discovered that natural intelligence is inductively created rather than exhaustively trained. Therefore, IM is a family of algebraic and denotational mathematics encompassing Inference Algebra, Real-Time Process Algebra, Concept Algebra, Semantic Algebra, Visual Frame Algebra, etc., developed in our labs. IM plays indispensable roles in training-free AI* theories and systems beyond traditional empirical data-driven technologies. A set of applications of IM-driven AI* systems will be demonstrated in contemporary intelligence science, AI*, and cognitive computers. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=intelligence%20mathematics" title="intelligence mathematics">intelligence mathematics</a>, <a href="https://publications.waset.org/abstracts/search?q=foundations%20of%20intelligent%20science" title=" foundations of intelligent science"> foundations of intelligent science</a>, <a href="https://publications.waset.org/abstracts/search?q=autonomous%20AI" title=" autonomous AI"> autonomous AI</a>, <a href="https://publications.waset.org/abstracts/search?q=cognitive%20computers" title=" cognitive computers"> cognitive computers</a>, <a href="https://publications.waset.org/abstracts/search?q=inference%20algebra" title=" inference algebra"> inference algebra</a>, <a href="https://publications.waset.org/abstracts/search?q=real-time%20process%20algebra" title=" real-time process algebra"> real-time process algebra</a>, <a href="https://publications.waset.org/abstracts/search?q=concept%20algebra" title=" concept algebra"> concept algebra</a>, <a href="https://publications.waset.org/abstracts/search?q=semantic%20algebra" title=" semantic algebra"> semantic algebra</a>, <a href="https://publications.waset.org/abstracts/search?q=applications" title=" applications"> applications</a> </p> <a href="https://publications.waset.org/abstracts/182399/on-the-framework-of-contemporary-intelligent-mathematics-underpinning-intelligent-science-autonomous-ai-and-cognitive-computers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/182399.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">61</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> An Innovative Poly System Theory for the Go-Out of Chinese Culture</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Wang">Jianhua Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ying%20Zhou"> Ying Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Han%20Guo"> Han Guo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Translation underwent culture turn for more than half a century, which brought translation and its studies beyond intra-texts. Different cultures in recent years have developed towards a translation turn, which made a great contribution to relocate national or local cultures being localized to become regional or global cultures. As China grows quickly economically integrating into the world, it becomes urgent to relate China’s story and disseminate the Chinese culture. Due to the weaknesses and drawbacks of different existing cultural translation theories for Chinese culture to go out, a new perspective on translation turn for the go-out of Chinese culture should be drawn to spread better and disseminate Chinese culture to other countries. Based on the existing cultural translation theories, the equivalence of ideology, style of the translator and agency of the support are proposed to draw a new perspective: an innovative poly-system theory for Chinese culture translation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cultural%20translation%20theory" title="cultural translation theory">cultural translation theory</a>, <a href="https://publications.waset.org/abstracts/search?q=Chinese%20culture" title=" Chinese culture"> Chinese culture</a>, <a href="https://publications.waset.org/abstracts/search?q=innovative%20poly%20system" title=" innovative poly system"> innovative poly system</a>, <a href="https://publications.waset.org/abstracts/search?q=global%20cultures" title=" global cultures"> global cultures</a> </p> <a href="https://publications.waset.org/abstracts/57358/an-innovative-poly-system-theory-for-the-go-out-of-chinese-culture" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/57358.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> The Stage and Cause of Regional Industrial Specialization Evolution in China</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Cheng%20Wen">Cheng Wen</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhang%20Jianhua"> Zhang Jianhua</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper aims to probe into the general rules of industry specialization or diversification in a region during its process of economic growth and the specific reasons for the difference of industry specialization development in the eastern, central and western regions of China. It is found in this paper that the changes of regional industry specialization in China, like most of countries in the world, also present the U-shaped curve. Regional industrial structure is diversified in the first place. And when the per capita income exceeds a certain level, distribution of economic resources in this region will be concentrated again. From the perspective of rising total factor productivity and falling of transaction cost in the process of economic development, this paper comes up with a theoretical model to explain the U-shaped curve. Through the empirical test of China's provincial panel data, this paper explains the factors that cause the inequality of the industry specialization development in the eastern, central and western regions of China. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=u-shaped%20curve" title="u-shaped curve">u-shaped curve</a>, <a href="https://publications.waset.org/abstracts/search?q=regional%20industrial%20specialization" title=" regional industrial specialization"> regional industrial specialization</a>, <a href="https://publications.waset.org/abstracts/search?q=technological%20progress" title=" technological progress"> technological progress</a>, <a href="https://publications.waset.org/abstracts/search?q=transaction%20costs" title=" transaction costs"> transaction costs</a> </p> <a href="https://publications.waset.org/abstracts/47255/the-stage-and-cause-of-regional-industrial-specialization-evolution-in-china" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47255.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">308</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> The Effects of Learning Engagement on Interpreting Performance among English Major Students</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Wang">Jianhua Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ying%20Zhou"> Ying Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Xi%20%20Zhang"> Xi Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> To establish the influential mechanism of learning engagement on interpreter’s performance, the present study submitted a questionnaire to a sample of 927 English major students with 804 valid ones and used the structural equation model as the basis for empirical analysis and statistical inference on the sample data. In order to explore the mechanism for interpreting learning engagement on student interpreters’ performance, a path model of interpreting processes with three variables of ‘input-environment-output’ was constructed. The results showed that the effect of each ‘environment’ variable on interpreting ability was different from and greater than the ‘input’ variable, and learning engagement was the greatest influencing factor. At the same time, peer interaction on interpreting performance has significant influence. Results suggest that it is crucial to provide effective guidance for optimizing learning engagement and interpreting teaching research by both improving the environmental support and building the platform of peer interaction, beginning with learning engagement. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=learning%20engagement" title="learning engagement">learning engagement</a>, <a href="https://publications.waset.org/abstracts/search?q=interpreting%20performance" title=" interpreting performance"> interpreting performance</a>, <a href="https://publications.waset.org/abstracts/search?q=interpreter%20training" title=" interpreter training"> interpreter training</a>, <a href="https://publications.waset.org/abstracts/search?q=English%20major%20students" title=" English major students"> English major students</a> </p> <a href="https://publications.waset.org/abstracts/112290/the-effects-of-learning-engagement-on-interpreting-performance-among-english-major-students" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/112290.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">207</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Optimized Text Summarization Model on Mobile Screens for Sight-Interpreters: An Empirical Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Wang">Jianhua Wang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> To obtain key information quickly from long texts on small screens of mobile devices, sight-interpreters need to establish optimized summarization model for fast information retrieval. Four summarization models based on previous studies were studied including title+key words (TKW), title+topic sentences (TTS), key words+topic sentences (KWTS) and title+key words+topic sentences (TKWTS). Psychological experiments were conducted on the four models for three different genres of interpreting texts to establish the optimized summarization model for sight-interpreters. This empirical study shows that the optimized summarization model for sight-interpreters to quickly grasp the key information of the texts they interpret is title+key words (TKW) for cultural texts, title+key words+topic sentences (TKWTS) for economic texts and topic sentences+key words (TSKW) for political texts. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=different%20genres" title="different genres">different genres</a>, <a href="https://publications.waset.org/abstracts/search?q=mobile%20screens" title=" mobile screens"> mobile screens</a>, <a href="https://publications.waset.org/abstracts/search?q=optimized%20summarization%20models" title=" optimized summarization models"> optimized summarization models</a>, <a href="https://publications.waset.org/abstracts/search?q=sight-interpreters" title=" sight-interpreters"> sight-interpreters</a> </p> <a href="https://publications.waset.org/abstracts/57345/optimized-text-summarization-model-on-mobile-screens-for-sight-interpreters-an-empirical-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/57345.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">314</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> A Multigrid Approach for Three-Dimensional Inverse Heat Conduction Problems</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Zhou">Jianhua Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuwen%20Zhang"> Yuwen Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A two-step multigrid approach is proposed to solve the inverse heat conduction problem in a 3-D object under laser irradiation. In the first step, the location of the laser center is estimated using a coarse and uniform grid system. In the second step, the front-surface temperature is recovered in good accuracy using a multiple grid system in which fine mesh is used at laser spot center to capture the drastic temperature rise in this region but coarse mesh is employed in the peripheral region to reduce the total number of sensors required. The effectiveness of the two-step approach and the multiple grid system are demonstrated by the illustrative inverse solutions. If the measurement data for the temperature and heat flux on the back surface do not contain random error, the proposed multigrid approach can yield more accurate inverse solutions. When the back-surface measurement data contain random noise, accurate inverse solutions cannot be obtained if both temperature and heat flux are measured on the back surface. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=conduction" title="conduction">conduction</a>, <a href="https://publications.waset.org/abstracts/search?q=inverse%20problems" title=" inverse problems"> inverse problems</a>, <a href="https://publications.waset.org/abstracts/search?q=conjugated%20gradient%20method" title=" conjugated gradient method"> conjugated gradient method</a>, <a href="https://publications.waset.org/abstracts/search?q=laser" title=" laser"> laser</a> </p> <a href="https://publications.waset.org/abstracts/91353/a-multigrid-approach-for-three-dimensional-inverse-heat-conduction-problems" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/91353.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">369</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> The Contact Behaviors of Seals Under Combined Normal and Tangential Loading: A Multiscale Finite Element Contact Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Runliang%20Wang">Runliang Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Liu"> Jianhua Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Duo%20Jia"> Duo Jia</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiaoyu%20Ding"> Xiaoyu Ding</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The contact between sealing surfaces plays a vital role in guaranteeing the sealing performance of various seals. To date, analyses of sealing structures have rarely considered both structural parameters (macroscale) and surface roughness information (microscale) of sealing surfaces due to the complex modeling process. Meanwhile, most of the contact analyses applied to seals were conducted only under normal loading, which still existssome distance from real loading conditions in engineering. In this paper, a multiscale rough contact model, which took both macrostructural parameters of seals and surface roughness information of sealing surfaces into consideration for the cone-cone seal, was established. By using the finite element method (FEM), the combined normal and tangential loading was applied to the model to simulate the assembly process of the cone-cone seal. The evolution of the contact behaviors during the assembly process, such as the real contact area (RCA), the distribution of contact pressure, and contact status, are studied in detail. The results showed the non-linear relationship between the RCA and the load, which was different from the normal loading cases. In addition, the evolution of the real contact area of cone-cone seals with isotropic and anisotropic rough surfaces are also compared quantitatively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=contact%20mechanics" title="contact mechanics">contact mechanics</a>, <a href="https://publications.waset.org/abstracts/search?q=FEM" title=" FEM"> FEM</a>, <a href="https://publications.waset.org/abstracts/search?q=randomly%20rough%20surface" title=" randomly rough surface"> randomly rough surface</a>, <a href="https://publications.waset.org/abstracts/search?q=real%20contact%20area" title=" real contact area"> real contact area</a>, <a href="https://publications.waset.org/abstracts/search?q=sealing" title=" sealing"> sealing</a> </p> <a href="https://publications.waset.org/abstracts/140262/the-contact-behaviors-of-seals-under-combined-normal-and-tangential-loading-a-multiscale-finite-element-contact-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140262.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">183</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Deep Feature Augmentation with Generative Adversarial Networks for Class Imbalance Learning in Medical Images</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rongbo%20Shen">Rongbo Shen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Yao"> Jianhua Yao</a>, <a href="https://publications.waset.org/abstracts/search?q=Kezhou%20Yan"> Kezhou Yan</a>, <a href="https://publications.waset.org/abstracts/search?q=Kuan%20Tian"> Kuan Tian</a>, <a href="https://publications.waset.org/abstracts/search?q=Cheng%20Jiang"> Cheng Jiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ke%20Zhou"> Ke Zhou</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study proposes a generative adversarial networks (GAN) framework to perform synthetic sampling in feature space, i.e., feature augmentation, to address the class imbalance problem in medical image analysis. A feature extraction network is first trained to convert images into feature space. Then the GAN framework incorporates adversarial learning to train a feature generator for the minority class through playing a minimax game with a discriminator. The feature generator then generates features for minority class from arbitrary latent distributions to balance the data between the majority class and the minority class. Additionally, a data cleaning technique, i.e., Tomek link, is employed to clean up undesirable conflicting features introduced from the feature augmentation and thus establish well-defined class clusters for the training. The experiment section evaluates the proposed method on two medical image analysis tasks, i.e., mass classification on mammogram and cancer metastasis classification on histopathological images. Experimental results suggest that the proposed method obtains superior or comparable performance over the state-of-the-art counterparts. Compared to all counterparts, our proposed method improves more than 1.5 percentage of accuracy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=class%20imbalance" title="class imbalance">class imbalance</a>, <a href="https://publications.waset.org/abstracts/search?q=synthetic%20sampling" title=" synthetic sampling"> synthetic sampling</a>, <a href="https://publications.waset.org/abstracts/search?q=feature%20augmentation" title=" feature augmentation"> feature augmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=generative%20adversarial%20networks" title=" generative adversarial networks"> generative adversarial networks</a>, <a href="https://publications.waset.org/abstracts/search?q=data%20cleaning" title=" data cleaning"> data cleaning</a> </p> <a href="https://publications.waset.org/abstracts/114272/deep-feature-augmentation-with-generative-adversarial-networks-for-class-imbalance-learning-in-medical-images" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/114272.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">127</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> A Study of Anoxic - Oxic Microbiological Technology for Treatment of Heavy Oily Refinery Wastewater</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Di%20Wang">Di Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Li%20Fang"> Li Fang</a>, <a href="https://publications.waset.org/abstracts/search?q=Shengyu%20Fang"> Shengyu Fang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Li"> Jianhua Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Honghong%20Dong"> Honghong Dong</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhongzhi%20Zhang"> Zhongzhi Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Heavy oily refinery wastewater with the characteristics of high concentration of toxic organic pollutant, poor biodegradability and complicated dissolved recalcitrant compounds is intractable to be degraded. In order to reduce the concentrations of COD and total nitrogen pollutants which are the major pollutants in heavy oily refinery wastewater, the Anoxic - Oxic microbiological technology relies mainly on anaerobic microbial reactor which works with methanogenic archaea mainly that can convert organic pollutants to methane gas, and supplemented by aerobic treatment. The results of continuous operation for 2 months with a hydraulic retention time (HRT) of 60h showed that, the COD concentration from influent water of anaerobic reactor and effluent water from aerobic reactor were 547.8mg/L and 93.85mg/L, respectively. The total removal rate of COD was up to 84.9%. Compared with the 46.71mg/L of total nitrogen pollutants in influent water of anaerobic reactor, the concentration of effluent water of aerobic reactor decreased to 14.11mg/L. In addition, the average removal rate of total nitrogen pollutants reached as high as 69.8%. Based on the data displayed, Anoxic - Oxic microbial technology shows a great potential to dispose heavy oil sewage in energy saving and high-efficiency of biodegradation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anoxic%20-%20oxic%20microbiological%20technology" title="anoxic - oxic microbiological technology">anoxic - oxic microbiological technology</a>, <a href="https://publications.waset.org/abstracts/search?q=COD" title=" COD"> COD</a>, <a href="https://publications.waset.org/abstracts/search?q=heavy%20oily%20refinery%20wastewater" title=" heavy oily refinery wastewater"> heavy oily refinery wastewater</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20nitrogen%20pollutant" title=" total nitrogen pollutant"> total nitrogen pollutant</a> </p> <a href="https://publications.waset.org/abstracts/41908/a-study-of-anoxic-oxic-microbiological-technology-for-treatment-of-heavy-oily-refinery-wastewater" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41908.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">493</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Energy Consumption Statistic of Gas-Solid Fluidized Beds through Computational Fluid Dynamics-Discrete Element Method Simulations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lei%20Bi">Lei Bi</a>, <a href="https://publications.waset.org/abstracts/search?q=Yunpeng%20Jiao"> Yunpeng Jiao</a>, <a href="https://publications.waset.org/abstracts/search?q=Chunjiang%20Liu"> Chunjiang Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Chen"> Jianhua Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Wei%20Ge"> Wei Ge</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Two energy paths are proposed from thermodynamic viewpoints. Energy consumption means total power input to the specific system, and it can be decomposed into energy retention and energy dissipation. Energy retention is the variation of accumulated mechanical energy in the system, and energy dissipation is the energy converted to heat by irreversible processes. Based on the Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) framework, different energy terms are quantified from the specific flow elements of fluid cells and particles as well as their interactions with the wall. Direct energy consumption statistics are carried out for both cold and hot flow in gas-solid fluidization systems. To clarify the statistic method, it is necessary to identify which system is studied: the particle-fluid system or the particle sub-system. For the cold flow, the total energy consumption of the particle sub-system can predict the onset of bubbling and turbulent fluidization, while the trends of local energy consumption can reflect the dynamic evolution of mesoscale structures. For the hot flow, different heat transfer mechanisms are analyzed, and the original solver is modified to reproduce the experimental results. The influence of the heat transfer mechanisms and heat source on energy consumption is also investigated. The proposed statistic method has proven to be energy-conservative and easy to conduct, and it is hopeful to be applied to other multiphase flow systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=energy%20consumption%20statistic" title="energy consumption statistic">energy consumption statistic</a>, <a href="https://publications.waset.org/abstracts/search?q=gas-solid%20fluidization" title=" gas-solid fluidization"> gas-solid fluidization</a>, <a href="https://publications.waset.org/abstracts/search?q=CFD-DEM" title=" CFD-DEM"> CFD-DEM</a>, <a href="https://publications.waset.org/abstracts/search?q=regime%20transition" title=" regime transition"> regime transition</a>, <a href="https://publications.waset.org/abstracts/search?q=heat%20transfer%20mechanism" title=" heat transfer mechanism"> heat transfer mechanism</a> </p> <a href="https://publications.waset.org/abstracts/176312/energy-consumption-statistic-of-gas-solid-fluidized-beds-through-computational-fluid-dynamics-discrete-element-method-simulations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/176312.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">68</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Characteristic Composition and Sensory Contributions of Acidic Aroma in Mainstream Cigarette Smoke of Cherry-Red Tobacco</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tian%20Yangyang">Tian Yangyang</a>, <a href="https://publications.waset.org/abstracts/search?q=Xu%20Zihe"> Xu Zihe</a>, <a href="https://publications.waset.org/abstracts/search?q=Lu%20Junping"> Lu Junping</a>, <a href="https://publications.waset.org/abstracts/search?q=Yang%20Jizhou"> Yang Jizhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Xu%20Yiqun"> Xu Yiqun</a>, <a href="https://publications.waset.org/abstracts/search?q=Wang%20Jiansong"> Wang Jiansong</a>, <a href="https://publications.waset.org/abstracts/search?q=Chen%20Chao"> Chen Chao</a>, <a href="https://publications.waset.org/abstracts/search?q=Yang%20Mengmeng"> Yang Mengmeng</a>, <a href="https://publications.waset.org/abstracts/search?q=Guo%20Jianhua"> Guo Jianhua</a>, <a href="https://publications.waset.org/abstracts/search?q=Mu%20Wenjun"> Mu Wenjun</a>, <a href="https://publications.waset.org/abstracts/search?q=Wang%20Guiyao"> Wang Guiyao</a>, <a href="https://publications.waset.org/abstracts/search?q=Xue%20Chaoqun"> Xue Chaoqun</a>, <a href="https://publications.waset.org/abstracts/search?q=Liang%20Taibo"> Liang Taibo</a>, <a href="https://publications.waset.org/abstracts/search?q=Hu%20Liwei"> Hu Liwei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cherry-red tobacco is receiving constant attention from cigarette enterprises because of its special flavor. This study aims to explore the material basis for the formation of the characteristic flavor of cherry-red tobacco and to clarify the distribution characteristics of the acidic aroma component groups in its mainstream smoke. In order to reach the aims of current study, this study employs GC/MS to examine the differences of distribution characteristics in particulate matter of mainstream cigarette smoke between cherry-red and common tobacco, meanwhile the aroma activity values (OVA) was used to compare the contribution of acidic aroma of cherry-red tobacco. The results showed that: 1) Isovaleric acid, acetic acid and butyric acid were the key acidic components in the mainstream smoke of the samples, followed by 3-methylvaleric acid, 4-methylvaleric acid and n-valeric acid. 2)Analysis of the release of these key sour fragrance components showed that the acidic aroma of "YUN 85" mainstream smoke was stronger than the leaf group, cherry-red tobacco was the weakest. In addition, aging had the effect of reducing the acidic components of cherry-red tobacco and the addition of cherry-red tobacco had little effect on the acidic components of the original leaf group. 3) For 14 acidic aroma(OAV>1) in smoke of cherry-red tobacco, 3-methylpentanoic acid, 4-methylpentanoic acid, pentanoic acid, and isovaleric acid were very prominent in contributing to acidic aroma, while pyruvic acid, 2-methylbutyric acid, hydrogenated acid, and propionic acid were less contribution. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cherry-red%20tobacco" title="cherry-red tobacco">cherry-red tobacco</a>, <a href="https://publications.waset.org/abstracts/search?q=acidic%20aroma" title=" acidic aroma"> acidic aroma</a>, <a href="https://publications.waset.org/abstracts/search?q=GC%2FMS" title=" GC/MS"> GC/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=mainstream%20cigarette%20smoke" title=" mainstream cigarette smoke"> mainstream cigarette smoke</a>, <a href="https://publications.waset.org/abstracts/search?q=odor%20activity%20value" title=" odor activity value"> odor activity value</a> </p> <a href="https://publications.waset.org/abstracts/157217/characteristic-composition-and-sensory-contributions-of-acidic-aroma-in-mainstream-cigarette-smoke-of-cherry-red-tobacco" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/157217.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> A Multi-Stage Learning Framework for Reliable and Cost-Effective Estimation of Vehicle Yaw Angle</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zhiyong%20Zheng">Zhiyong Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Xu%20Li"> Xu Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Liang%20Huang"> Liang Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhengliang%20Sun"> Zhengliang Sun</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Xu"> Jianhua Xu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Yaw angle plays a significant role in many vehicle safety applications, such as collision avoidance and lane-keeping system. Although the estimation of the yaw angle has been extensively studied in existing literature, it is still the main challenge to simultaneously achieve a reliable and cost-effective solution in complex urban environments. This paper proposes a multi-stage learning framework to estimate the yaw angle with a monocular camera, which can deal with the challenge in a more reliable manner. In the first stage, an efficient road detection network is designed to extract the road region, providing a highly reliable reference for the estimation. In the second stage, a variational auto-encoder (VAE) is proposed to learn the distribution patterns of road regions, which is particularly suitable for modeling the changing patterns of yaw angle under different driving maneuvers, and it can inherently enhance the generalization ability. In the last stage, a gated recurrent unit (GRU) network is used to capture the temporal correlations of the learned patterns, which is capable to further improve the estimation accuracy due to the fact that the changes of deflection angle are relatively easier to recognize among continuous frames. Afterward, the yaw angle can be obtained by combining the estimated deflection angle and the road direction stored in a roadway map. Through effective multi-stage learning, the proposed framework presents high reliability while it maintains better accuracy. Road-test experiments with different driving maneuvers were performed in complex urban environments, and the results validate the effectiveness of the proposed framework. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gated%20recurrent%20unit" title="gated recurrent unit">gated recurrent unit</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-stage%20learning" title=" multi-stage learning"> multi-stage learning</a>, <a href="https://publications.waset.org/abstracts/search?q=reliable%20estimation" title=" reliable estimation"> reliable estimation</a>, <a href="https://publications.waset.org/abstracts/search?q=variational%20auto-encoder" title=" variational auto-encoder"> variational auto-encoder</a>, <a href="https://publications.waset.org/abstracts/search?q=yaw%20angle" title=" yaw angle"> yaw angle</a> </p> <a href="https://publications.waset.org/abstracts/127783/a-multi-stage-learning-framework-for-reliable-and-cost-effective-estimation-of-vehicle-yaw-angle" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/127783.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> High-Risk Gene Variant Profiling Models Ethnic Disparities in Diabetes Vulnerability </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Zhang">Jianhua Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Weiping%20Chen"> Weiping Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Guanjie%20Chen"> Guanjie Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jason%20Flannick"> Jason Flannick</a>, <a href="https://publications.waset.org/abstracts/search?q=Emma%20Fikse"> Emma Fikse</a>, <a href="https://publications.waset.org/abstracts/search?q=Glenda%20Smerin"> Glenda Smerin</a>, <a href="https://publications.waset.org/abstracts/search?q=Yanqin%20Yang"> Yanqin Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yulong%20Li"> Yulong Li</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20A.%20Hanover"> John A. Hanover</a>, <a href="https://publications.waset.org/abstracts/search?q=William%20F.%20Simonds"> William F. Simonds</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ethnic disparities in many diseases are well recognized and reflect the consequences of genetic, behavior, and environmental factors. However, direct scientific evidence connecting the ethnic genetic variations and the disease disparities has been elusive, which may have led to the ethnic inequalities in large scale genetic studies. Through the genome-wide analysis of data representing 185,934 subjects, including 14,955 from our own studies of the African America Diabetes Mellitus, we discovered sets of genetic variants either unique to or conserved in all ethnicities. We further developed a quantitative gene function-based high-risk variant index (hrVI) of 20,428 genes to establish profiles that strongly correlate with the subjects' self-identified ethnicities. With respect to the ability to detect human essential and pathogenic genes, the hrVI analysis method is both comparable with and complementary to the well-known genetic analysis methods, pLI and VIRlof. Application of the ethnicity-specific hrVI analysis to the type 2 diabetes mellitus (T2DM) national repository, containing 20,791 cases and 24,440 controls, identified 114 candidate T2DM-associated genes, 8.8-fold greater than that of ethnicity-blind analysis. All the genes identified are defined as either pathogenic or likely-pathogenic in ClinVar database, with 33.3% diabetes-associated and 54.4% obesity-associated genes. These results demonstrate the utility of hrVI analysis and provide the first genetic evidence by clustering patterns of how genetic variations among ethnicities may impede the discovery of diabetes and foreseeably other disease-associated genes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes-associated%20genes" title="diabetes-associated genes">diabetes-associated genes</a>, <a href="https://publications.waset.org/abstracts/search?q=ethnic%20health%20disparities" title=" ethnic health disparities"> ethnic health disparities</a>, <a href="https://publications.waset.org/abstracts/search?q=high-risk%20variant%20index" title=" high-risk variant index"> high-risk variant index</a>, <a href="https://publications.waset.org/abstracts/search?q=hrVI" title=" hrVI"> hrVI</a>, <a href="https://publications.waset.org/abstracts/search?q=T2DM" title=" T2DM"> T2DM</a> </p> <a href="https://publications.waset.org/abstracts/131697/high-risk-gene-variant-profiling-models-ethnic-disparities-in-diabetes-vulnerability" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/131697.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">137</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Phosphate Regulation of Arbuscular Mycorrhiza Symbiosis in Rice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Debatosh%20Das">Debatosh Das</a>, <a href="https://publications.waset.org/abstracts/search?q=Moxian%20Chen"> Moxian Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Zhang"> Jianhua Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Caroline%20Gutjahr"> Caroline Gutjahr</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Arbuscular mycorrhiza (AM) is a mutualistic symbiosis between plant roots and Glomeromycotina fungi, which is activated under low but inhibited by high phosphate. The effect of phosphate on AM development has been observed for many years, but mechanisms regulating it under contrasting phosphate levels remain unknown. Based on previous observations that promoters of several AM functional genes contain PHR binding motifs, we hypothesized that PHR2, a master regulator of phosphate starvation response in rice, was recruited to regulate AM symbiosis development. We observed a drastic reduction in root colonization and significant AM transcriptome modulation in phr2. PHR2 targets genes required for root colonization and AM signaling. The role of PHR2 in improving root colonization, mycorrhizal phosphate uptake, and growth response was confirmed in field soil. In conclusion, rice PHR2, which is considered a master regulator of phosphate starvation responses, acts as a positive regulator of AM symbiosis between Glomeromycotina fungi and rice roots. PHR2 directly targets the transcription of plant strigolactone and AM genes involved in the establishment of this symbiosis. Our work facilitates an understanding of ways to enhance AMF propagule populations introduced in field soils (as a biofertilizer) in order to restore the natural plant-AMF networks disrupted by modern agricultural practices. We show that PHR2 is required for AM-mediated improvement of rice yield in low phosphate paddy field soil. Thus, our work contributes knowledge for rational application of AM in sustainable agriculture. Our data provide important insights into the regulation of AM by the plant phosphate status, which has a broad significance in agriculture and terrestrial ecosystems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biofertilizer" title="biofertilizer">biofertilizer</a>, <a href="https://publications.waset.org/abstracts/search?q=phosphate" title=" phosphate"> phosphate</a>, <a href="https://publications.waset.org/abstracts/search?q=mycorrhiza" title=" mycorrhiza"> mycorrhiza</a>, <a href="https://publications.waset.org/abstracts/search?q=rice" title=" rice"> rice</a>, <a href="https://publications.waset.org/abstracts/search?q=sustainable" title=" sustainable"> sustainable</a>, <a href="https://publications.waset.org/abstracts/search?q=symbiosis" title=" symbiosis"> symbiosis</a> </p> <a href="https://publications.waset.org/abstracts/156401/phosphate-regulation-of-arbuscular-mycorrhiza-symbiosis-in-rice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156401.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">133</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Precise Spatially Selective Photothermolysis Skin Treatment by Multiphoton Absorption</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yimei%20Huang">Yimei Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Harvey%20Lui"> Harvey Lui</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianhua%20Zhao"> Jianhua Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhenguo%20Wu"> Zhenguo Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=Haishan%20Zeng"> Haishan Zeng</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Conventional laser treatment of skin diseases and cosmetic surgery is based on the principle of one-photon absorption selective photothermolysis which relies strongly on the difference in the light absorption between the therapeutic target and its surrounding tissue. However, when the difference in one-photon absorption is not sufficient, collateral damage would occur due to indiscriminate and nonspecific tissue heating. To overcome this problem, we developed a spatially selective photothermolysis method based on multiphoton absorption in which the heat generation is restricted to the focal point of a tightly focused near-infrared femtosecond laser beam aligned with the target of interest. A multimodal optical microscope with co-registered reflectance confocal imaging (RCM), two-photon fluorescence imaging (TPF), and second harmonic generation imaging (SHG) capabilities was used to perform and monitor the spatially selective photothermolysis. Skin samples excised from the shaved backs of euthanized NODSCID mice were used in this study. Treatments were performed by focusing and scaning the laser beam in the dermis with a 50µm×50µm target area. Treatment power levels of 200 mW to 400 mW and modulated pulse trains of different duration and period were experimented. Different treatment parameters achieved different degrees of spatial confinement of tissue alterations as visualized by 3-D RCM/TPF/SHG imaging. At 200 mW power level, 0.1 s pulse train duration, 4.1 s pulse train period, the tissue damage was found to be restricted precisely to the 50µm×50µm×10µm volume, where the laser focus spot had scanned through. The overlying epidermis/dermis tissue and the underneath dermis tissue were intact although there was light passing through these regions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multiphoton%20absorption%20photothermolysis" title="multiphoton absorption photothermolysis">multiphoton absorption photothermolysis</a>, <a href="https://publications.waset.org/abstracts/search?q=reflectance%20confocal%20microscopy" title=" reflectance confocal microscopy"> reflectance confocal microscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=second%20harmonic%20generation%20microscopy" title=" second harmonic generation microscopy"> second harmonic generation microscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=spatially%20selective%20photothermolysis" title=" spatially selective photothermolysis"> spatially selective photothermolysis</a>, <a href="https://publications.waset.org/abstracts/search?q=two-photon%20fluorescence%20microscopy" title=" two-photon fluorescence microscopy"> two-photon fluorescence microscopy</a> </p> <a href="https://publications.waset.org/abstracts/67745/precise-spatially-selective-photothermolysis-skin-treatment-by-multiphoton-absorption" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67745.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">515</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a 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