Molecular Controls, OEM Services, Molecular Assay Reagents

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Areas</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-therapeutic-manufacturing" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Therapeutic Manufacturing <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-therapeutic-manufacturing" aria-labelledby="navbarDropdown-therapeutic-manufacturing"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Reagents & Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/reagents/cell-culture-reagents/serum-free-animal-free" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3576">Animal-Free Cell Culture</a> <a href="/reagents/elisa-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/176">ELISA Kits</a> <a 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href="/gmp-products/ruo-to-gmp" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3421">Transition to GMP </a> <a href="/gmp-products/loa-request" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13326">DMF/LOA Request</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/applications/immuno-oncology-clinical" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2066">Immuno-Oncology</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-diagnostics" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Diagnostics <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-diagnostics" aria-labelledby="navbarDropdown-diagnostics"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Controls & Reagents<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/clinical-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7606">Clinical Quality Controls</a> <a href="/diagnostics/molecular-quality-controls" class="dropdown-item text-wrap is-active" data-drupal-link-system-path="node/5596" aria-current="page">Molecular Controls</a> <a href="/diagnostics/controls-reagents/rnascope-ish-probe-high-risk-hpv" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5981">RNAscope™ ISH Probe High Risk HPV</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/amplidex-genetic-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5581">Genetics</a> <a href="/diagnostics/quantidex-oncology-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5586">Oncology</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Technology<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/exosome" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5486">Exosome Platform</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> OEM Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/ivd-assay-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10881">IVD Assay Development</a> <a href="/diagnostics/ivd-contract-manufacturing" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7381">IVD Contract Manufacturing</a> <a href="/diagnostics/molecular-quality-controls/oem-and-commercial-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6781">Molecular Diagnostic OEM Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Companion Diagnostics<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/companion-diagnostics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5631">Companion Diagnostics Services</a> <a href="/diagnostics/companion-diagnostics/multiomics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10616">Multiomics Platform</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-services" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Services <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-services" aria-labelledby="navbarDropdown-services"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Quotes<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/bulk-quotes" class="dropdown-item text-wrap" data-drupal-link-system-path="services/bulk-quotes">Bulk Quote Discounts</a> <a href="/services/custom-formulation" class="dropdown-item text-wrap" data-drupal-link-system-path="services/custom-formulation">Custom Formulation Quotes</a> <a href="/reagents/rnascope-ish-technology/probes/custom" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12571">RNAscope Custom Probe Design Quote</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/custom-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1891">All Custom Services</a> <a href="/services/custom-antibody-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/906">Custom Antibody Services</a> <a href="/services/custom-cell-and-gene-therapy-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1281">Custom Cell & Gene Therapy Services</a> <a href="/services/custom-compound-library-service" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2126">Custom Compound Library Services</a> <a href="/services/custom-elisa-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/261">Custom ELISA Services</a> <a href="/services/gene-engineering-services-tcbuster" class="dropdown-item text-wrap" title="Gene Engineering Services: Bio-Techne" data-drupal-link-system-path="node/1136">Custom Gene Engineering Services</a> <a href="/services/custom-luminex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/271">Custom Luminex Services</a> <a href="/services/custom-protein-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1441">Custom Protein Services</a> <a href="/services/custom-simple-plex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6296">Custom Simple Plex Services</a> <a href="/services/custom-targeted-protein-degradation-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/861">Custom Targeted Protein Degradation Services</a> <a href="/services/professional-assay-services-rnascope" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12306">RNAscope Professional Assay Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/certified-service-provider-program" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5446">Certified Service Provider (CSP) Program</a> <a href="/resources/instrument-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5471">Contract Services</a> <a href="/services/instrument-services/simple-western-service-plans" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3181">Simple Western Service Plans</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Licensing<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/biotechnology-licensing-partnering" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1101">Biotechnology Licensing and Partnering</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-resources" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Resources <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-resources" aria-labelledby="navbarDropdown-resources"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup Tool</a> <a href="/resources/rnascope-citations" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/rnascope-citations">RNAscope Citations</a> <a href="/resources/simple-plex-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-plex-panel-builder">Simple Plex Panel Builder</a> <a href="/resources/simple-western-kit-builder" class="dropdown-item text-wrap" 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</div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/banners/asu-diagnostics-controls-hero-floater-sized3.png" alt="molecular control" fetchpriority="high" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </header> </div> <div id="main" class="container-fluid container-wide"> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/diagnostics">Diagnostics</a> </li> <li> Molecular Quality Controls </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--_-1-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--75-25"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:3_1_text_to_media:field_header_2_global"> <div><h2>Armored Controls for Molecular Diagnostic Workflows</h2></div> </div> <div class="field_block:paragraph:3_1_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Asuragen, a Bio-Techne brand, provides robust, reliable molecular controls built on more than 20 years of product development and manufacturing expertise. Our <a href="/resources/literature/detection-of-sars-cov-2-armored-rna-global-interlaboratory-harmonization-study">Armored RNA<sup>®</sup></a>, <a href="/literature/detection-of-sars-cov-2-armored-rna-poster">Armored RNA Quant<sup>®</sup></a>, <a href="/resources/literature/using-armored-rna-dna-reliable-molecular-controls-infectious-disease-testing-beyond">Armored DNA Quant™</a>, plasmid DNA (circular and linearized), and <em>in vitro</em> transcribed RNA provide unique, target-specific solutions to meet all your molecular QC needs.<a name="armored"></a></p></div> </div> <div class="field_block:paragraph:3_1_text_to_media:field_call_to_action_global"> <a href="/diagnostics/molecular-quality-controls/catalog" class="btn btn-primary" type="link"> Our Catalog of Armored Products </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:3_1_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/banners/asu-diagnostics-controls-armoredrna-card.png" alt="molecular diagnostic workflow" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <article> <div class="youtube-video-place"> <lite-youtube videoid="kMN09pI3JTE" params="rel=0" style="background-image: url('https://img.youtube.com/vi/kMN09pI3JTE/maxresdefault.jpg');"> <a href="https://www.youtube.com/embed/kMN09pI3JTE?autoplay=1" class="lty-playbtn" title="Bio-Techne Molecular Controls - Armored RNA Quant®"> <span class="lyt-visually-hidden">Bio-Techne Molecular Controls - Armored RNA Quant®</span> </a> </lite-youtube> </div> </article> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h2>What is Armored RNA Quant Technology?</h2></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Armored RNA<sup>®</sup> technologies stabilize and protect nucleic acids from nuclease degradation by packaging them in a protective protein coat. Armored reagents deliver several end-user benefits, for an optimized workflow.</p> <h4><em><strong>Watch the Video to Learn More About Stable, Non-Infectious, and Customizable Armored Control Process<a name="Controls"></a></strong></em></h4> <p><em><strong><a href="https://bio-techne.com/diagnostics/molecular-quality-controls/best-practices">Bio-Techne's Armored Molecular Controls Best Practices</a></strong></em></p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/banners/asu-diagnostics-controls-reducedcomplexity-card.png" alt="reduce complexity" loading="lazy" > </div> </div> </div> <h3 class="card_title_htag"> <div><h2>Reduced Complexity</h2></div> </h3> <div class="card_description flex-grow-1"> <div><ul> <li>Available as catalog molecular controls or customized</li> <li>High-quality control solutions to monitor extraction and process efficiency</li> <li>Non-infectious, synthetic molecular constructs simplify shipping, handling, and storage</li> </ul></div> </div> <div class="card-bottom-link"></div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/banners/asu-diagnostics-controls-optimizedworkflow-card.png" alt="optimized workflow" loading="lazy" > </div> </div> </div> <h3 class="card_title_htag"> <div><h2>Optimized Workflow</h2></div> </h3> <div class="card_description flex-grow-1"> <div><ul> <li>Deployable as extractable, exogenous internal positive controls</li> <li>Degradation-resistant in majority of biological matrices</li> <li>Multiple configuration and custom manufacturing options available</li> </ul></div> </div> <div class="card-bottom-link"></div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/banners/asu-diagnostics-controls-qualityperformance-card.png" alt="quality performance" loading="lazy" > </div> </div> </div> <h3 class="card_title_htag"> <div><h2>Quality Performance</h2></div> </h3> <div class="card_description flex-grow-1"> <div><ul> <li>Available as cGMP controls and manufactured under an ISO 13485 quality system </li> <li>Validated targets and concentrations determined using metrological, traceable standards</li> <li>Highly standardized, quality-controlled manufacturing ensures reliability and consistency</li> </ul></div> </div> <div class="card-bottom-link"></div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2>Molecular Diagnostic OEM Services</h2> <h4>Assay Development Through Global Commercialization</h4> <p>With a cGMP manufacturing facility governed by our ISO 13485 certified quality system, we can provide customized target Armored RNA and Armored DNA as well as custom multiplexed panels. Extensive quality control measures support products derived from any step of the manufacturing process, including plasmid DNA (circular or linearized) and in vitro transcribed RNA. Custom targets are available in three different grades: evaluation, development, and cGMP.</p> <h4>Delivering custom design, reliable service, and seamless integration for molecular diagnostic manufacturers</h4></div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/molecular-diagnostic-oem-service-process-v2.png" alt="Custom Armored Molecular Controls manufacturing roadmap" loading="lazy" > </div> </div> </div> <div> <div class="paragraph paragraph--type--individual-button mb-4 paragraph--view-mode--default w-100"> <div class="row"> <div class="col"> <a href="/diagnostics/molecular-quality-controls/oem-and-commercial-services" class="btn btn-primary float-left" type="link" > Partner with Us for OEM Services </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Molecular Assay Reagents<h2></h2></h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Our molecular assay reagents assist in various capacities, including sample transport, sample stability, and product development.</p> <ul> <li>TSM III is a buffered solution ideally suited for the dilution of Armored products. The additives provide stability to the protein-coated nucleic acid through multiple freeze-thaw cycles when stored properly, allowing for more flexible and scalable testing processes.</li> <li><em>RNARetain<sup>®</sup></em> is intended for the collection, storage, and transportation of fresh tissue specimens for subsequent RNA isolation and further molecular diagnostic testing. The collection of fresh tissue specimens into the RNA<em>Retain</em> device eliminates the need to immediately process these specimens, enabling RNA extraction and molecular testing at a later time and/or transport to a different location.</li> </ul></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="/diagnostics/molecular-quality-controls/catalog#reagents" class="btn btn-primary" type="link"> Our Catalog of Molecular Assay Reagents </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/banners/asu-diagnostics-controls-molecularreagents-card.jpg" alt="molecular assay reagents" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Tumor Bank</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><h3>A unique tumor bank of >100,000 clinical specimens.</h3> <p>The specimens span over 100 discrete cancer types across all major classes including melanoma, ovarian, breast, colon, and non-small-cell lung cancers. Our specimens are formalin-fixed, paraffin-embedded (FFPE) tissues, the majority of which are coupled with full histologic and demographic information.</p></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="#form" class="btn btn-primary" type="link"> Email Us About Our Tumor Bank Inventory </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <a href="https://www.bio-techne.com#form" title="Email Us About Our Tumor Bank Inventory" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/immuno-oncology-cancer-cell-500x300.png" alt="Immuno-oncology cancer cell" loading="lazy" > </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><em>Armored RNA and Armored RNA Quant are registered trademarks and Armored DNA Quant is a trademark of Asuragen and Cenetron Diagnostics. RNARetain is a registered trademark of Asuragen.</em></p> <p><sup>*</sup>For Research Use Only. Not For Use in Diagnostic Procedures</p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="faq"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Frequently Asked Questions</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h3>Ordering Molecular Quality Controls</h3></div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-how-to-order-bio-technes-molecular-quality-controls14" role="button" aria-expanded="false" aria-controls="expPara"> <h5>How to order Bio-Techne’s Molecular Quality Controls?</h5> </a> </div> <div class="collapse" id="expPara-how-to-order-bio-technes-molecular-quality-controls14" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p><a href="#form" target="_self">Contact Us</a> for more information about our Molecular Quality Controls</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-is-the-lead-time-for-delivery-of-custom-molecular-quality-controls8" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What is the lead time for delivery of custom Molecular Quality Controls?</h5> </a> </div> <div class="collapse" id="expPara-what-is-the-lead-time-for-delivery-of-custom-molecular-quality-controls8" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li>An average turn-around time for custom control delivery is 8-12 weeks.</li> <li>Timelines are dependent on project complexity and resource availability.</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-how-are-the-molecular-quality-controls-prepared-for-shipment17" role="button" aria-expanded="false" aria-controls="expPara"> <h5>How are the Molecular Quality Controls prepared for shipment?</h5> </a> </div> <div class="collapse" id="expPara-how-are-the-molecular-quality-controls-prepared-for-shipment17" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>All molecular control products are shipped on dry ice unless another shipping format is specified by the customer.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-can-molecular-quality-controls-be-subdivided-into-smaller-volumes10" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Can Molecular Quality Controls be subdivided into smaller volumes?</h5> </a> </div> <div class="collapse" id="expPara-can-molecular-quality-controls-be-subdivided-into-smaller-volumes10" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>We offer custom filling services for customers specified volumes per tube.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-can-the-molecular-quality-controls-be-custom-formulated-to-a-specific-concentration0" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Can the Molecular Quality Controls be custom formulated to a specific concentration?</h5> </a> </div> <div class="collapse" id="expPara-can-the-molecular-quality-controls-be-custom-formulated-to-a-specific-concentration0" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li>Armored RNA - filled as-is or formulated to ≤ 0.25 mg/mL</li> <li>Armored RNA Quant/DNA Quant - can be formulated to any concentration equal to or below 1.0E+12 copies/mL</li> <li>Plasmid DNA - filled as-is or formulated to ≤ 0.1 mg/mL</li> <li>Linearized DNA - filled as-is or formulated to ≤ 0.1 mg/mL</li> <li>In vitro transcribed RNA - filled as-is or formulated to ≤ 2.0 mg/mL</li> <li>Customer-defined concentrations outside of these ranges will be considered</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h3>General Handling</h3></div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-is-the-recommended-storage-temperature-for-molecular-quality-controls17" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What is the recommended storage temperature for Molecular Quality Controls?</h5> </a> </div> <div class="collapse" id="expPara-what-is-the-recommended-storage-temperature-for-molecular-quality-controls17" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Molecular Quality Controls should be stored at the following temperatures:</p> <ul> <li><a href="https://asuragen.com/moleculardx-controls-portfolio/mdx-catalog-products/" target="_blank">Armored RNA</a> 2 to 8°C</li> <li><a href="https://asuragen.com/portfolio/armored-rna-quant-sars-cov-2-controls" target="_blank">Armored RNA/DNA Quant</a> -15 to -30°C</li> <li><a href="https://asuragen.com/moleculardx-controls-portfolio/mdx-made-to-order-products/" target="_blank">Plasmid DNA</a> -15 to -30°C</li> <li>Linearized DNA -15 to -30°C</li> <li>In vitro transcribed RNA -70 to -85°C</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-is-the-recommended-storage-solution-for-molecular-quality-controls20" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What is the recommended storage solution for Molecular Quality Controls?</h5> </a> </div> <div class="collapse" id="expPara-what-is-the-recommended-storage-solution-for-molecular-quality-controls20" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>The following Molecular Quality Controls should be stored accordingly:</p> <ul> <li>Armored RNA - TSMIII storage buffer, available for purchase through Asuragen, a Bio-Techne brand</li> <li>Armored RNA/DNA Quant - TSMIII storage buffer, available for purchase through Asuragen, a Bio-Techne brand</li> <li>Plasmid DNA - TE (10mM Tris-HCl pH 8.0, 1 mM EDTA)</li> <li>Linearized DNA - TE (10mM Tris-HCl pH 8.0, 1 mM EDTA)</li> <li>In vitro Transcribed RNA - variable (sodium citrate, 0.1 mM EDTA, nuclease-free water, or as defined by the customer)</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-do-molecular-quality-controls-remain-stable-upon-freeze-thawing19" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Do Molecular Quality Controls remain stable upon freeze-thawing?</h5> </a> </div> <div class="collapse" id="expPara-do-molecular-quality-controls-remain-stable-upon-freeze-thawing19" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li>Freeze-thaws should be kept to a minimum for all nucleic acid reagents.</li> <li>Armored reagents should not be subjected to more than five freeze thaw cycles.</li> <li>It is recommended to distribute into single-use aliquots upon receipt; we also offer custom aliquoting services to suit your laboratory workflow.</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-are-there-assigned-expiration-dates-to-molecular-quality-controls11" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Are there assigned expiration dates to Molecular Quality Controls?</h5> </a> </div> <div class="collapse" id="expPara-are-there-assigned-expiration-dates-to-molecular-quality-controls11" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li>Expiration dates are assigned only on molecular controls that have undergone appropriate stability studies.</li> <li>Representative Armored RNA Quant control products have demonstrated stability up to 3 years when stored at -15 to -30°C or 6 months when stored at 2 to 8°C after opening.</li> <li>No expiration date is applied to <a href="https://asuragen.com/moleculardx-controls-portfolio/mdx-made-to-order-products/" target="_blank">custom molecular controls</a> unless specified by customer; it is the customer’s responsibility to apply expiration dating based on their own stability program.</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-is-simple-heat-treatment-sufficient-to-release-template-dnarna-from-armored-particles8" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Is simple heat treatment sufficient to release template DNA/RNA from Armored particles?</h5> </a> </div> <div class="collapse" id="expPara-is-simple-heat-treatment-sufficient-to-release-template-dnarna-from-armored-particles8" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li>Incubation for at least 5 minutes at 75°C is sufficient to release the DNA/RNA from the protective pseudo-capsid for direct analysis. Armored reagents are compatible with most DNA/ RNA extraction methods.</li> <li>For samples with low nucleic acid content (e.g. blood plasma), addition of an RNA or DNA carrier is recommended to improve recovery of Armored RNA and Armored DNA.</li> <li>For extraction methods that include a white blood cell enrichment step, please ensure the Armored particles are added to the cell pellet before processing into lysate.</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h3>Manufacturing Information</h3></div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-standards-are-in-place-during-the-manufacturing-of-molecular-quality-controls17" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What standards are in place during the manufacturing of Molecular Quality Controls?</h5> </a> </div> <div class="collapse" id="expPara-what-standards-are-in-place-during-the-manufacturing-of-molecular-quality-controls17" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li>Manufactured under ISO 13485 Quality System.</li> <li>Restricted laboratory access and laboratory gowning procedures.</li> <li>Physically and spatially segregated equipment and manufacturing processes.</li> <li>Dedicated Master Cell Banks.</li> <li>All open work performed in ISO Class 5 enclosures.</li> <li>Rigorous cleaning regimen: weekly, before and after material manipulation.</li> <li>GMP manufacturing available.</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-how-are-the-molecular-quality-controls-quantified16" role="button" aria-expanded="false" aria-controls="expPara"> <h5>How are the Molecular Quality Controls quantified?</h5> </a> </div> <div class="collapse" id="expPara-how-are-the-molecular-quality-controls-quantified16" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><ul> <li>Armored RNA - UV spectrophotometry</li> <li>Armored RNA/DNA Quant - analytical phosphate assay that utilizes a NIST-traceable standard</li> <li>Plasmid DNA - UV spectrophotometry</li> <li>Linearized DNA - UV spectrophotometry</li> <li>In vitro transcribed RNA - UV spectrophotometry</li> <li>Customer-defined quantification methods will be considered.</li> </ul></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-how-are-molecular-quality-controls-manufactured16" role="button" aria-expanded="false" aria-controls="expPara"> <h5>How are Molecular Quality Controls manufactured?</h5> </a> </div> <div class="collapse" id="expPara-how-are-molecular-quality-controls-manufactured16" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Please <a href="#form" target="_self">contact us</a> for more information, we are happy to share the basic workflow of our process.</p></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h3>Armored RNA Quant SARS-CoV-2</h3></div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-are-advantages-of-armored-rna-controls-compared-to-a-non-armored-rna-controls1" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What are advantages of Armored RNA Controls compared to a non-Armored RNA controls?</h5> </a> </div> <div class="collapse" id="expPara-what-are-advantages-of-armored-rna-controls-compared-to-a-non-armored-rna-controls1" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>The Armored process protects the RNA from degradation. This allows for its use as an extraction control as well as a process control. Additionally, the Armored capsid coat mimics viral coat proteins without being infectious, providing a safer alternative to live or inactivated virus controls.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-is-the-armored-rna-quant-sars-cov-2-pn-5215113" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What is the Armored RNA Quant SARS-CoV-2 (P/N 52151)?</h5> </a> </div> <div class="collapse" id="expPara-what-is-the-armored-rna-quant-sars-cov-2-pn-5215113" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p><a href="https://asuragen.com/portfolio/armored-rna-quant-sars-cov-2-controls/" target="_blank">Armored RNA Quant SARS-CoV-2</a> is an in vitro transcribed RNA encoding the SARS-CoV-2 viral nucleocapsid region that is encapsulated in phage coat protein particles. This sequence aligns with the CDC Diagnostic Panel N1/N2 and shares identity with at least 83 known isolates in the NCBI database.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-which-specific-sars-cov-2-isolate-was-used-to-design-armored-rna-quant-sars-cov-2-pn-5215114" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Which specific SARS-CoV-2 isolate was used to design Armored RNA Quant SARS-CoV-2 (P/N 52151)?</h5> </a> </div> <div class="collapse" id="expPara-which-specific-sars-cov-2-isolate-was-used-to-design-armored-rna-quant-sars-cov-2-pn-5215114" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Armored RNA Quant SARS-CoV-2 was originally designed against Wuhan isolate LR757998.1. The control sequence has 100% identity to 83 other isolates including Wuhan, Australia, USA, and Cruise.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-is-the-armored-rna-quant-sars-cov-2-panel-pn-5215315" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What is the Armored RNA Quant SARS-CoV-2 Panel (P/N 52153)?</h5> </a> </div> <div class="collapse" id="expPara-what-is-the-armored-rna-quant-sars-cov-2-panel-pn-5215315" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>It is a panel of in vitro transcribed RNA encoding the SARS-CoV-2 viral nucleocapsid, envelope, RNA- dependent RNA Polymerase, ORF1, and human RNase P regions that are encapsulated in phage coat protein particles.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-is-the-armored-rna-quant-respiratory-triplex-control-pn-5210825" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What is the Armored RNA Quant Respiratory Triplex Control (P/N 52108)?</h5> </a> </div> <div class="collapse" id="expPara-what-is-the-armored-rna-quant-respiratory-triplex-control-pn-5210825" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>This control contains multiplexed in vitro transcribed RNA encoding the SARS-CoV-2 viral nucleocapsid, Influenza, Respiratory Syncytial Virus, and RNase P regions encapsulated in phage coat protein particles. These sequence regions align with the US and China CDC and WHO recommended regions for SARS-CoV-2 testing.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-how-are-armored-rna-quant-sars-cov-2-controls-being-used11" role="button" aria-expanded="false" aria-controls="expPara"> <h5>How are Armored RNA Quant SARS-CoV-2 controls being used?</h5> </a> </div> <div class="collapse" id="expPara-how-are-armored-rna-quant-sars-cov-2-controls-being-used11" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>Armored RNA SARS-CoV-2 controls are being used as positive reference controls for testing laboratories and inclusion in diagnostic kits.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-what-is-the-armored-rna-quant-rnase-p-pn-5215218" role="button" aria-expanded="false" aria-controls="expPara"> <h5>What is the Armored RNA Quant RNase P (P/N 52152)?</h5> </a> </div> <div class="collapse" id="expPara-what-is-the-armored-rna-quant-rnase-p-pn-5215218" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>It is an in vitro transcribed RNA encoding the RNase P gene that is encapsulated in phage coat protein particles. This sequence aligns with the CDC Diagnostic Panel recommendation.</p></div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-how-is-rnase-p-control-being-used5" role="button" aria-expanded="false" aria-controls="expPara"> <h5>How is RNase P control being used?</h5> </a> </div> <div class="collapse" id="expPara-how-is-rnase-p-control-being-used5" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p>The RNase P control is being used as an assay positive control to ensure test systems are behaving optimally.</p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> 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