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href="https://www.cancerresearchuk.org/get-involved" class="mm-item-link">Get involved</a><span class="cr-i cr-i--chevron-down"></span></p> <div style="width: 940px"> <ul class="list-content" id="get-involved-menu"><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/get-involved/donate" class="level2">Donate</a></p><ul><li><a href="https://www.cancerresearchuk.org/get-involved/donate" class="level3">Make a donation</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/donate/donate-by-cancer-type" class="level3">By cancer type</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/leave-a-legacy-gift-in-your-will" class="level3">Leave a legacy gift</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/donate/donate-in-memory" class="level3">Donate in Memory</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/donate" class="level3">More...</a></li></ul></li><li class="toplevel"><p><a 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href="https://www.cancerresearchuk.org/get-involved/volunteer/volunteer-in-our-shops" class="level3">Volunteer in our shops</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/volunteer/help-at-an-event" class="level3">Help at an event</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/volunteer/help-us-raise-money" class="level3">Help us raise money</a></li><li><a href="https://www.cancerresearchuk.org/how-to-cancer-campaign" class="level3">Campaign for us</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/volunteer" class="level3">More...</a></li></ul></li><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/get-involved/do-your-own-fundraising" class="level2">Do your own fundraising</a></p><ul><li><a href="https://www.cancerresearchuk.org/get-involved/do-your-own-fundraising/fundraising-ideas" class="level3">Fundraising ideas</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/do-your-own-fundraising/get-fundraising-pack" class="level3">Get a fundraising pack</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/do-your-own-fundraising/return-your-money" class="level3">Return fundraising money</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/do-your-own-fundraising/target-your-fundraising" class="level3">Fundraise by cancer type</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/do-your-own-fundraising/practical-fundraising-help/set-up-a-cancer-research-uk-giving-page" class="level3">Set up a Cancer Research UK Giving Page</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/do-your-own-fundraising" class="level3">More...</a></li></ul></li><li class="toplevel"><p>More...</p><ul><li><a href="https://www.cancerresearchuk.org/get-involved/find-a-shop" class="level3">Find a shop or superstore</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/become-a-partner" class="level3">Become a partner</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/donate/kids-and-teens" class="level3">Cancer Research UK for Children & Young People</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/we-are" class="level3">Our We Are campaign</a></li></ul></li></ul> </div> </li><li class="mm-item"><p><a href="https://www.cancerresearchuk.org/our-research" class="mm-item-link">Our research</a><span class="cr-i cr-i--chevron-down"></span></p> <div style="width: 940px"> <ul class="list-content" id="our-research-menu"><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-type" class="level2">By cancer type</a></p><ul><li><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-type/our-research-on-brain-tumours" class="level3">Brain tumours</a></li><li><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-type/our-research-on-skin-cancer" class="level3">Skin cancer</a></li><li><a href="/our-research/our-research-by-cancer-type/our-research-on-breast-cancer" class="level3">Breast cancer</a></li><li><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-type" class="level3">All cancer types</a></li></ul></li><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-subject" class="level2">By cancer topic</a></p><ul><li><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-subject/our-research-on-clinical-trials" class="level3">New treatments</a></li><li><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-subject/our-research-on-cancer-biology" class="level3">Cancer biology</a></li><li><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-subject/our-research-on-cancer-drugs" class="level3">Cancer drugs</a></li><li><a href="https://www.cancerresearchuk.org/our-research/our-research-by-cancer-subject" class="level3">All cancer subjects</a></li></ul></li><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/our-research/our-research-near-you" class="level2">Near you</a></p><ul><li><a href="https://www.cancerresearchuk.org/our-research/our-research-near-you/our-research-in-belfast" class="level3">Belfast</a></li><li><a href="https://www.cancerresearchuk.org/our-research/our-research-near-you/our-research-in-cardiff" class="level3">Cardiff</a></li><li><a href="https://www.cancerresearchuk.org/our-research/our-research-near-you/our-research-in-edinburgh" class="level3">Edinburgh</a></li><li><a href="https://www.cancerresearchuk.org/our-research/our-research-near-you" class="level3">All locations</a></li></ul></li><li class="toplevel"><p>More...</p><ul><li><a href="https://www.cancerresearchuk.org/our-progress" class="level3">Our achievements timeline</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-research-strategy" class="level3">Our research strategy</a></li><li><a href="https://www.cancerresearchuk.org/our-research/involving-animals-in-research" class="level3">Involving animals in research</a></li></ul></li></ul> </div> </li><li class="mm-item selected"><p><a href="https://www.cancerresearchuk.org/funding-for-researchers" class="mm-item-link">Funding for researchers</a><span class="cr-i cr-i--chevron-down"></span></p> <div style="width: 940px"> <ul class="list-content" id="funding-for-researchers-menu"><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/funding-for-researchers" class="level2">Research opportunities</a></p><ul><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/research-opportunities-in-basic-science-and-discovery-research" class="level3">For discovery researchers</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/clinical-research" class="level3">For clinical researchers</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/research-opportunities-in-population-and-behavioural-research" class="level3">For population researchers</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/drug-discovery-and-development" class="level3">In drug discovery & development</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/research-opportunities-in-early-detection-and-diagnosis" class="level3">In early detection & diagnosis</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/opportunities-for-phd-students-and-postdoc-researchers" class="level3">For students & postdocs</a></li></ul></li><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-funding-schemes?items_per_page=40" class="level2">Our funding schemes</a></p><ul><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-funding-schemes/career-development-fellowship" class="level3">Career Development Fellowship</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-funding-schemes/discovery-programme-awards" class="level3">Discovery Programme Awards</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-funding-schemes/clinical-trial-award-0" class="level3">Clinical Trial Award</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-funding-schemes/biology-to-prevention-award" class="level3">Biology to Prevention Award</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-funding-schemes" class="level3">View all schemes and deadlines</a></li></ul></li><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/funding-for-researchers/applying-for-funding" class="level2">Applying for funding</a></p><ul><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/applying-for-funding/start-your-funding-application-online" class="level3">Start your application online</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/applying-for-funding/how-to-make-a-successful-application" class="level3">How to make a successful application</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/applying-for-funding/funding-committees" class="level3">Funding committees</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/applying-for-funding/how-to-make-a-successful-application/successful-applicant-case-studies" class="level3">Successful applicant case studies</a></li></ul></li><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research" class="level2">How we deliver research</a></p><ul><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-research-strategy" class="level3">Our research strategy</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/our-research-infrastructure" class="level3">Our research infrastructure</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/research-events-and-conferences" class="level3">Events and conferences</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/our-research-partnerships" class="level3">Our research partnerships</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/facts-and-figures-about-our-research-funding" class="level3">Facts & figures about our funding</a></li></ul></li><li class="toplevel"><p>More...</p><ul><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/patient-involvement-toolkit-for-researchers" class="level3">Patient involvement toolkit for researchers</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/research-career-development-opportunities" class="level3">Develop your research career</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/recently-funded-awards" class="level3">Recently funded awards</a></li><li><a href="https://www.cancerresearchuk.org/funding-for-researchers/manage-your-research-grant" class="level3">Manage your research grant</a></li><li><a href="https://www.cancerresearchuk.org/home/funding-for-researchers/manage-your-research-grant/tell-us-about-new-publications" class="level3">Notify us of new publications</a></li></ul></li></ul> </div> </li><li class="mm-item"><p><a href="https://www.cancerresearchuk.org/get-involved/ways-to-shop" class="mm-item-link">Shop</a><span class="cr-i cr-i--chevron-down"></span></p> <div style="width: 940px"> <ul class="list-content" id="shop-menu"><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/get-involved/find-a-shop" class="level2">Find a shop</a></p><ul><li><a href="https://www.cancerresearchuk.org/get-involved/volunteer/volunteer-in-our-shops" class="level3">Volunteer in a shop</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/donate/donate-goods" class="level3">Donate goods to a shop</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/ways-to-shop/superstores" class="level3">Our superstores</a></li></ul></li><li class="toplevel"><p><a href="https://shop.cancerresearchuk.org/" class="level2">Shop online</a></p><ul><li><a href="https://shop.cancerresearchuk.org/pages/race-for-life" class="level3">Race for Life</a></li><li><a href="https://shop.cancerresearchuk.org/products/wedding-favours" class="level3">Wedding favours</a></li><li><a href="https://shop.cancerresearchuk.org/cancer-care" class="level3">Cancer Care</a></li><li><a href="https://flowershop.cancerresearchuk.org/" class="level3">Flower 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beat cancer</a></li><li><a href="https://www.cancerresearchuk.org/get-involved/how-your-support-helps" class="level3">We fundraise</a></li><li><a href="https://www.cancerresearchuk.org/about-us/we-develop-policy" class="level3">We develop policy</a></li><li><a href="https://www.cancerresearchuk.org/global-role" class="level3">Our global role</a></li></ul></li><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/about-us/our-organisation" class="level2">Our organisation</a></p><ul><li><a href="https://www.cancerresearchuk.org/about-us/our-organisation/beating-cancer-sooner-our-strategy" class="level3">Our strategy</a></li><li><a href="https://www.cancerresearchuk.org/about-us/how-we-are-run/our-trustees" class="level3">Our Trustees</a></li><li><a href="https://www.cancerresearchuk.org/about-us/how-we-are-run/chief-executive-and-executive-board" class="level3">CEO and Executive Board</a></li><li><a href="https://www.cancerresearchuk.org/about-us/our-organisation/how-we-spend-your-money" class="level3">How we spend your money</a></li></ul></li><li class="toplevel"><p><a href="https://www.cancerresearchuk.org/about-us/careers" class="level2">Careers</a></p><ul><li><a href="https://www.cancerresearchuk.org/about-us/careers/early-in-career-opportunities" class="level3">Early careers</a></li><li><a href="https://www.cancerresearchuk.org/about-us/careers/teams" class="level3">Our teams</a></li><li><a href="https://www.cancerresearchuk.org/about-us/careers/benefits" class="level3">Benefits</a></li></ul></li><li class="toplevel"><p><a href="https://news.cancerresearchuk.org/" class="level2">Cancer news</a></p><ul><li><a href="https://news.cancerresearchuk.org/" class="level3">Cancer News</a></li><li><a href="https://news.cancerresearchuk.org/for-researchers/" class="level3">For Researchers</a></li><li><a href="https://news.cancerresearchuk.org/for-supporters/" class="level3">For 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field-type-text-with-summary"> <div class="field-item" property="content:encoded"><p>This page lists the investigator-led programmes, projects and fellowships that we have recently supported through our response-mode grant funding schemes.</p> <p><strong>Select a funding committee to see what they have funded to date in 2024-25 (for Grant Award Letters issued up to August 2024):</strong><br /> </p> </div> </div> <div class="panel-separator"></div> <div class="panel-pane pane-fieldable-panels-pane pane-current-961 pane-bundle-accordion-panel-pane" > <div class="pane-content"> <div class="panel-group" id="accordion-Recentlyfundedawards">  <div class="panel panel-default"> <div class="panel-heading"> <h2 class="panel-title" id="Recentlyfundedawards0"> <a data-toggle="collapse" class="" data-parent="#accordion-Recentlyfundedawards" href="#collapseRecentlyfundedawards0"> Clinical Research Committee </a> </h2> </div> <div id="collapseRecentlyfundedawards0" class="panel-collapse in"> <div class="panel-body"> <h2>May 2024</h2> <h2><a href="http://funding-for-researchers/our-funding-schemes/biomarker-project-awards">Biomarker Project Awards</a></h2> <p><strong>Dr Alexandra Clipson and Dr Alicia-Marie Conway (University of Manchester)</strong></p> <p>Determining tissue-of-origin from circulating free DNA profiling for diagnosis of Cancers of Unknown Primary</p> <p><strong>Dr Nicholas McGranahan and Dr James Black (University College London)</strong></p> <p>GENESIS: Genomic Evaluation of a Novel Ensemble Signature for Immunotherapy Stratification</p> <h2><a href="/funding-for-researchers/our-funding-schemes/prospective-sample-collection-awards">Prospective Sample Collection Awards</a></h2> <p><strong>Dr Ashwin Sachdeva, Professor Noel Clarke and Professor Gert Attard (University of Manchester and University College London)</strong></p> <p>Collection of diagnostic tissue blocks from the STAMPEDE metformin trial in advanced prostate cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-phase-and-feasibility-study-awards">Clinical Trial Awards</a></h2> <p><strong>Professor Adele Fielding (University College London)</strong></p> <p>UKALL15</p> <p><strong>Professor Gordon Cook and Dr Charlotte Pawlyn (University of Leeds and Institute of Cancer Research)</strong></p> <p>UK-MRA Myeloma XVIII iFIT: Immunotherapy approaches adapted for Fitness In newly diagnosed Transplant ineligible patients with Myeloma</p> <h2><a href="/funding-for-researchers/our-funding-schemes/experimental-medicine-award">Experimental Medicine Awards</a></h2> <p><strong>Professor Gary Middleton and Professor Caroline Dive (University of Birmingham and University of Manchester)</strong></p> <p>A translational programme for DETERMINE (Determining Extended Therapeutic indications for Existing drugs in Rare Molecularly-defined Indications using a National Evaluation platform trial)</p> <p> </p> <h2>November 2023</h2> <h2><a href="http://funding-for-researchers/our-funding-schemes/biomarker-project-awards">Biomarker Project Awards</a></h2> <p><strong>Professor Ming-Qing Du (University of Cambridge)</strong></p> <p>Precision Prognostic Utility of MYC translocation in Aggressive B-cell lymphomas</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-phase-and-feasibility-study-awards">Clinical Trial Awards</a></h2> <p><strong>Dr Frederik van Delft (Newcastle University)</strong></p> <p>Hem-iSmart international early phase clinical trial platform</p> <p><strong>Professor Steven Knapper and Dr Richard Dillon (Cardiff University and Kings College London)</strong></p> <p>Optimise-FLT3 Study: Optimising therapy for patients with FLT3-mutated Acute Myeloid Leukaemia</p> <p><strong>Dr Fiona McDonald and Prof Judith Bliss (Institute of Cancer Research)</strong></p> <p>HALT - Targeted therapy with or without dose intensified radiotherapy for oligo-progressive disease in oncogene-addicted lung tumours (Costed Extension)</p> <p> </p> <h2>July 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/prospective-sample-collection-awards">Prospective Sample Collection Awards</a></h2> <p><strong>Dr Anna Wilkins and Professor Emma Hall (Institute of Cancer Research)</strong></p> <p>3P sample collection application</p> <p><strong>Dr Ann Henry, Dr Finbar Slevin, Dr Alexandra Clipson (University of Leeds)</strong></p> <p>POINTER-PC SC: Evaluating molecular markers of radiotherapy efficacy and toxicity for pelvic nodal recurrence in prostate cancer</p> <p><strong>Dr Christopher Williams and Professor Andrew Beggs (University of Leeds)</strong></p> <p>ctDNA collection within the ARIEL trial: A biomarker enrichment trial of anti-EGFR agents in right primary tumour location, RAS wild-type, advanced colorectal cancer (aCRC)</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-phase-and-feasibility-study-awards">Clinical Trial Awards</a></h2> <p><strong>Professor Gordon Jayson and Professor Richard Adams (University of Manchester)</strong></p> <p>VALTIVE1b: Validation of Tie2 for VEGF inhibitors in Patients With Ovarian Cancer Treated With Olaparib and Bevacizumab Maintenance Therapy: Optimising the Design (Costed Extension)</p> <p><strong>Professor Michael Schmid, Professor Paula Ghaneh, Dr Ainhoa Mielgo, Professor Daniel Palmer (University of Liverpool)</strong></p> <p>Investigating the translational potential of inhibiting AXL in combination with adjuvant chemotherapy in the treatment of pancreatic cancer. (Pre-Clinical Package)</p> <h2><a href="/funding-for-researchers/our-funding-schemes/experimental-medicine-award">Experimental Medicine Awards</a></h2> <p><strong>Professor Louis Chesler, Professor Darren Hargrave and Dr Isidro Cortés-Ciriano (Institute of Cancer Research)</strong></p> <p>Stratified Medicine Paediatrics 2 (StratMedPaediatrics2)<br /> </p> <h2>March 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/early-phase-and-feasibility-study-awards">Clinical Trial Awards</a></h2> <p><strong>Professor Darren Hargrave, University of Birmingham</strong></p> <p>CRUK/23/002: BIOMEDE 2.0: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication</p> <p><strong>Dr Reuben Benjamin, Professor Christina Yap, Dr Charlotte Graham, Dr John Maher, King's College Hospital NHS Foundation Trust</strong></p> <p>CRUK/23/003: pCAR19: Phase 1, open label, dose escalation study evaluating the safety and efficacy of next generation anti-CD19 parallel chimeric antigen receptor T cells (pCAR19) in patients with relapsed/refractory B-cell lymphomas</p> <h2><a href="/funding-for-researchers/our-funding-schemes/prospective-sample-collection-awards">Prospective Sample Collection Awards</a></h2> <p><strong>Dr Elizabeth Phillips, Dr Kim Linton, University of Manchester</strong></p> <p>RADAR sample collection: a randomised phase III study with a PET response-adapted design comparing ABVD +/- ISRT with A2VD +/- ISRT in patients with previously untreated stage IA/IIA Hodgkin lymphoma</p> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading"> <h2 class="panel-title" id="Recentlyfundedawards1"> <a data-toggle="collapse" class="" data-parent="#accordion-Recentlyfundedawards" href="#collapseRecentlyfundedawards1"> Discovery Research Committee </a> </h2> </div> <div id="collapseRecentlyfundedawards1" class="panel-collapse in"> <div class="panel-body"> <h2>June 2024</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/discovery-programme-awards">Programme Awards</a></h2> <p><strong><span><span><span><span><span>Professor Jessica Downs (Institute of Cancer Research)</span></span></span></span></span></strong></p> <p><span><span><span><span>Investigating the contribution of chromatin dynamics to DNA damage responses and genome stability</span></span></span></span></p> <p><strong><span><span><span><span><span>Professor Zoltan Takats, Dr Burak Temelkuran, Prof Sadaf Ghaem- Maghami, Prof Josephine Bunch (Imperial College London and National Physical Laboratory)</span></span></span></span></span></strong></p> <p><span><span><span><span>Cancer surgery at systems medicine level: simultaneous molecular mapping and resecting of solid tumours using spectroscopically guided semi-autonomous surgical robots</span></span></span></span></p> <p><strong><span><span><span><span><span>Professor Sergio Quezada (University College London)</span></span></span></span></span></strong></p> <p><span><span><span><span>Deciphering Immune Reactivities and Regulatory Contexture in Brain Tumours to Advance the Development of Novel Immunotherapies.</span></span></span></span></p> <p><strong><span><span><span><span><span>Professor Alan Warren (University of Cambridge)</span></span></span></span></span></strong></p> <p><span><span><span><span>Targeting the ribosome as a pan-cancer therapy</span></span></span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/programme-foundation-awards">Programme Foundation Awards</a></h2> <p><strong><span><span><span><span><span>Dr Paul Elliott (University of Oxford)</span></span></span></span></span></strong></p> <p><span><span><span><span>Controlling survival of aneuploid glioma cancer cells through E3 ubiquitin ligases: role of BIRC6 and UBR4</span></span></span></span></p> <p><strong><span><span><span><span><span>Dr Sarah McClelland (Queen Mary University London)</span></span></span></span></span></strong></p> <p><span><span><span><span>Defining the origins and vulnerabilities of cancer chromosomal instability</span></span></span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/multidisciplinary-project-award">Multidisciplinary Project Awards</a></h2> <p><strong><span><span><span><span><span>Dr Fernando Perez-Cota, Dr Alan McIntyre, Dr Matt Clark (University of Nottingham)</span></span></span></span></span></strong></p> <p><span><span><span><span>The sound of Cancer: towards elasticity biomarkers</span></span></span></span></p> <p><strong><span><span><span><span><span>Dr Emma Harris and Professor Kairbaan Hodivala-Dilke (Institute of Cancer Research and Queen Mary University London)</span></span></span></span></span></strong></p> <p><span><span><span><span>Tools for the early signposting of treatment resistance and metastasis in pancreatic cancer.</span></span></span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/cancer-immunology-project-awards">Cancer Immunology Project Awards</a></h2> <p><strong><span><span><span><span><span>Professor Kevin Marchbank and Professor Helen Reeves (Newcastle University)</span></span></span></span></span></strong></p> <p><span><span><span><span>Hyperactive complement driving inflam-ageing: a shortcut to cancer?</span></span></span></span></p> <p><strong><span><span><span><span><span>Professor Irina Udalova and Professor Iain McNeish (University of Oxford and Imperial College London)</span></span></span></span></span></strong></p> <p><span><span><span><span>Decoding spatiotemporal heterogeneity of neutrophil subsets during ovarian cancer</span></span></span></span></p> <h2>November 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/discovery-programme-awards">Programme Awards</a></h2> <h3>New Programmes</h3> <p><strong><span><span><span>Professor Linda Wooldridge (University of Bristol)</span></span></span></strong></p> <p><span><span>Identification of antigens targeted by T-cells mediating Graft-versus-Leukaemia and Graft-versus-Host Disease following Stem Cell Transplantation</span></span></p> <h3>Renewing Programmes</h3> <p><strong><span><span><span>Professor Pascal Meier (Institute of Cancer Research)</span></span></span></strong></p> <p><span><span>Harnessing Cell Death Mechanisms in Cancer</span></span></p> <p><strong><span><span><span>Professor Peter McHugh and Professor Christopher Schofield (University of Oxford)</span></span></span></strong></p> <p><span><span>Targeting nucleases for the treatment of cancer</span></span></p> <p><strong><span><span><span>Professor Jussi Taipale (University of Cambridge)</span></span></span></strong></p> <p><span><span>Identification and targeting of common regulatory mechanisms underlying major forms of human cancer</span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/programme-foundation-awards">Programme Foundation Awards</a></h2> <p><strong><span><span><span>Dr Luca Magnani (Institute of Cancer Research)</span></span></span></strong></p> <p><span><span>Disarming Dormancy: preventing evolution by targeting oestrogen receptor dormant cells in healthy and cancer tissues (DiDo)</span></span></p> <p><strong><span><span><span>Dr Nicholas McGranahan (University College London)</span></span></span></strong></p> <p><span><span>Dissecting Evolutionary phenotypes in Cancer by Investigating Plasticity and Heritability in Evolution and Resistance (DECIPHER)</span></span></p> <p><strong><span><span><span>Dr Audrey Gerard (University of Oxford)</span></span></span></strong></p> <p><span><span>Studying the coevolving cancer and immune landscapes – unravelling targetable pathways of immune adaptation</span></span></p> <p><strong><span><span><span>Dr Helen Rowe (Queen Mary University of London)</span></span></span></strong></p> <p><span><span>Crosstalk between chromatin remodelling and immune evasion in non-small cell lung cancer (NSCLC)</span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/multidisciplinary-project-award">Multidisciplinary Project Awards</a></h2> <p><strong><span><span><span>Professor Campbell Roxburgh, Professor Joanne Edwards and Professor Emiliano Spezi (University of Glasgow and Cardiff University)</span></span></span></strong></p> <p><span><span>Derivation of novel non-invasive radiomic and AI-based classifiers to determine molecular behaviour of rectal cancer and its treatment response to radiotherapy</span></span></p> <p><strong><span><span><span>Professor Oscar Ces and Professor Charlotte Bevan (Imperial College London)</span></span></span></strong></p> <p><span><span>Cancer Research UK & Prostate Cancer UK Innovation Award: Microenvironment-Remodelling Synthetic Cells for Cancer Drug Delivery (DRCMDP-May23/100012 and RIA22-ST2-010)</span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/cancer-immunology-project-awards">Cancer Immunology Project Awards</a></h2> <p><strong><span><span><span>Dr Ricardo Fernandes (University of Oxford)</span></span></span></strong></p> <p><span><span>Identification of structural and functional correlates of robust antitumour T cell responses</span></span></p> <p> </p> <h2>June 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/discovery-programme-awards">Programme Awards</a></h2> <h3>New Programmes</h3> <p><span><span><span><span><strong><span><span><span><span>Professor Katrin Ottersbach, University of Edinburgh</span></span></span></span></strong></span></span></span></span></p> <p><span><span><span><span><span><span><span><span>The role of the microenvironment in the initiation and maintenance of infant leukaemia</span></span></span></span></span></span></span></span></p> <p><span><span><span><span><strong><span><span><span><span>Dr Ingo Ringshausen, University of Cambridge</span></span></span></span></strong></span></span></span></span></p> <p><span><span><span><span><span><span><span><span>Oncogene & tumour suppressor-mediated remodelling of the tumour microenvironment in B cell lymphoproliferative diseases</span></span></span></span></span></span></span></span></p> <p><span><span><span><span><strong><span><span><span><span>Professor Simona Parrinello, University College London</span></span></span></span></strong><br /> <span><span><span><span>Glioblastoma Initiation and Re-initiation</span></span></span></span></span></span></span></span></p> <h3>Renewing Programmes</h3> <p><span><span><span><span><strong><span><span><span><span>Professor Christian Siebold, University of Oxford</span></span></span></span></strong></span></span></span></span></p> <p><span><span><span><span><span><span><span><span>Molecular Mechanisms of Morphogen Signalling in the Tumour Microenvironment</span></span></span></span></span></span></span></span></p> <p><span><span><span><span><strong><span><span><span><span>Professor Mark Cragg, Professor Stephen Beers, University of Southampton</span></span></span></span></strong></span></span></span></span><br /> <span><span><span><span><span><span><span><span>Targeting myeloid cells for improved antibody immunotherapy</span></span></span></span></span></span></span></span></p> <p><span><span><span><span><strong><span><span><span><span>Professor Ronald Hay, University of Dundee</span></span></span></span></strong></span></span></span></span></p> <p><span><span><span><span><span><span><span><span>New players in the targeted degradation of the PML-RARA oncogene by arsenic</span></span></span></span></span></span></span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/programme-foundation-awards">Programme Foundation Awards</a></h2> <p><span><span><span><span><strong><span><span><span><span>Dr Christopher Tape, University College London</span></span></span></span></strong></span></span></span></span></p> <p><span><span><span><span><span><span><span><span>Treatment Analysis via Individualised Organoid Responses (TAILOR)</span></span></span></span></span></span></span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/multidisciplinary-project-award">Multidisciplinary Project Awards</a></h2> <p><span><span><span><span><strong><span><span><span><span>Dr Ran Yan, Dr John Maher, Dr James Arnold, Prof Erik Arstad, Kings College London</span></span></span></span></strong></span></span></span></span></p> <p><span><span><span><span><span><span><span><span>Development of Novel 18F-labelled Molecular Probes for Long-Term CAR T-cell Tracking with Positron Emission Tomography (CART_PET)</span></span></span></span></span></span></span></span></p> <h2><a href="/funding-for-researchers/our-funding-schemes/cancer-immunology-project-awards">Cancer Immunology Project Awards</a></h2> <p><span><span><span><span><strong><span><span><span><span>Professor Jessica Strid, Imperial College London</span></span></span></span></strong></span></span></span></span></p> <p><span><span><span><span><span><span><span><span>Contribution of bioactive lipid mediators to inflammation and epithelial cancer development</span></span></span></span></span></span></span></span></p> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading"> <h2 class="panel-title" id="Recentlyfundedawards2"> <a data-toggle="collapse" class="" data-parent="#accordion-Recentlyfundedawards" href="#collapseRecentlyfundedawards2"> Early Detection and Diagnosis Research Committee </a> </h2> </div> <div id="collapseRecentlyfundedawards2" class="panel-collapse in"> <div class="panel-body"> <h2>May 2024</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-programme-award">Programme Awards</a></h2> <p><strong><span><span><span>Professor Nitzan Rosenfeld, Queen Mary University of London & Professor Mark Tischkowitz, University of Cambridge </span></span></span></strong><br /> Earlier diagnosis in women at high risk of breast and ovarian cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-project-award">Project Awards</a></h2> <p><strong>Professor Petra Hamerlik, University of Manchester</strong><br /> INFORM - non-invasive early detection of brain cancer using tear fluid proteome profiling</p> <p><strong><span><span><span>Dr Laura Woods & Dr Christina Dobson, Newcastle University</span></span></span></strong><br /> What does the introduction of Lung Health Checks (LHCs) in England mean for lung cancer inequalities? A mixed methods investigation.</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-primer-award">Primer Awards</a></h2> <p><strong><span><span><span>Dr Sarah Gosling, University of Keele</span></span></span></strong><br /> Early Detection of Ovarian Cancer: Interrogating The Tissue Microenvironment for Novel Biomarkers</p> <p><strong><span><span><span>Dr Faezeh Arab Hassani, University of Bristol</span></span></span></strong><br /> TACIMApatch: Tactile imaging patch for early detection of breast tumours</p> <p><strong><span><span><span>Dr Maria Paraskevaidi, Imperial College London</span></span></span></strong><br /> The use of high-throughput blood-based metabolomics for ovarian cancer early detection and diagnosis</p> <p><strong>Professor John Field, University of Liverpool</strong><br /> Multiomic Lung Cancer Early Detection</p> <p><strong><span><span><span>Dr Sarah Fry, Cardiff University</span></span></span></strong><br /> Acceptability and accessibility of using peer-led WhatsApp groups for sharing prostate cancer risk information between black men: a pilot study.</p> <p><strong><span><span><span>Dr Olena Mandrik, University of Sheffield</span></span></span></strong><br /> The use of high-throughput blood-based metabolomics for ovarian cancer early detection and diagnosis</p> <p><strong>Professor Anita Grigoriadis, King's College London & Professor Laszlo Radvanyi, Ontario Institute for Cancer Research</strong><br /> Transposable Element Activation in Pre-invasive and Early Invasive Breast Cancer Development in High-Risk Women: Developing a Spatial Proteogenomic and Liquid Biopsy Platform for Molecular Characterization and Early Detection</p> <p><strong>Dr Daniel Middleton, Queen's University Belfast & Dr Ismail Hosen, University of Dhaka</strong><br /> Liquid biopsy biomarkers for the early detection of bladder cancer in an arsenic exposed population (UroScan)</p> <p><strong>Dr Steven Ersser, Bournemouth University</strong><br /> Developing evidence and theory-informed digital videos employing a user-centred participatory approach, to support the early detection of skin cancer (EDSC) via self-examination of the skin (SSE), focused on at-risk (older men) and under-served populations (‘people of colour’)</p> <p><strong>Dr Christina Renzi, University College London</strong><br /> Cancer diagnosis in people with disability: a multi-methods international project on diagnostic pathways and cancer outcomes</p> <h2> </h2> <h2>November 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-programme-award">Programme Awards</a></h2> <p><strong><span><span><span>Professor David Weller, University of Edinburgh & Professor Peter Sasieni, Queen Mary University of London </span></span></span></strong><br /> Risk-based screening in UK colorectal cancer screening programmes</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-project-award">Project Awards</a></h2> <p><strong><span><span><span>Dr Massimiliano di Pietro, University of Cambridge & Dr Florian Markowetz, CRUK Cambridge Institute</span></span></span></strong><br /> Artificial intelligence based early detection of signet ring cell carcinoma in hereditary diffuse gastric cancer patients</p> <p><strong><span><span><span>Dr Ruchi Gupta, University of Birmingham</span></span></span></strong><br /> Smart Hydrogels and Devices for Early Detection of Cancer</p> <p><strong><span><span><span>Dr James Flanagan, Imperial College London</span></span></span></strong><br /> The Cancer Loyalty Card Study (CLOCS)</p> <p><strong><span><span><span>Dr Sarah Bailey, University of Exeter</span></span></span></strong><br /> Clinical utility of neutrophil-to-lymphocyte ratio in identifying patients at risk of cancer diagnosis in primary care: a cohort study using routine electronic health records</p> <p><strong><span><span><span>Professor Daryl O'Connor & Professor Mark Conner, University of Leeds</span></span></span></strong><br /> Increasing FIT bowel cancer screening uptake: Testing the effectiveness of two promising behaviour change interventions and their combination</p> <p><strong><span><span><span>Dr Rachel Evans & Dr Gilbert Fruhwirth, King's College London</span></span></span></strong><br /> ROR1 Detection As An Early Indicator Of Lung Cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-primer-award">Primer Awards</a></h2> <p><strong><span><span><span>Dr Harriet Quinn-Scoggins, Cardiff University</span></span></span></strong><br /> Preparing healthcare providers and the public for Multi Cancer Early Detection (MCED) blood tests: towards equitable implementation through co-creation</p> <p><strong><span><span><span>Dr Vasiliki Symeonidou, University of Cambridge</span></span></span></strong><br /> Improving early detection of individuals at high-risk of developing AML and related cancers</p> <p><strong><span><span><span>Dr Jihong Zhu, University of York & Dr Roisin Bradley, York and Scarborough Teaching Hospital NHS Foundation Trust</span></span></span></strong><br /> Robotic Positioning Assistance in Breast Screening</p> <p><strong><span><span><span>Dr Stephanie Archer, University of Cambridge</span></span></span></strong><br /> Integrating multifactorial risk assessment within secondary care breast services: co-designing a new pathway</p> <p><strong><span><span><span>Dr Kirsten Christensen-Jeffries, King's College London</span></span></span></strong><br /> Advanced Ultrasound Imaging for Early Cancer Detection and Diagnosis</p> <p><strong><span><span><span>Dr Takanori Kitamura, University of Edinburgh</span></span></span></strong><br /> Identification of macrophage-associated biomarkers to predict the progression of ductal carcinoma in situ (DCIS) into invasive breast cancer</p> <p>Professor Martin Widschwendter, University College London<br /> Establishing optimal and acceptable vaginal self-sampling for epigenetic-based endometrial cancer surveillance in women with Lynch Syndrome</p> <p><strong><span><span><span>Dr Jamie Weaver & Dr Susanne Flach, LMU Klinikum Munich</span></span></span></strong><br /> Understanding the timings of mutations and microenvironmental changes in head and neck squamous cell carcinoma and associated field cancerization to develop better biomarkers for high-risk patient surveillance and early detection</p> <p><strong><span><span><span>Dr Hector Huerga Encabo & Professor Dominique Bonnet, The Francis Crick Institute</span></span></span></strong><br /> Detection of early steps of blood cancer</p> <p> </p> <h2>May 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-project-award">Project Awards</a></h2> <p><strong><span><span><span>Professor Peter Murchie, University of Aberdeen</span></span></span></strong><br /> Achieving Self-directed Integrated Cancer Aftercare (ASICA) in melanoma: Optimising the intervention using pilot evidence, assisted intelligence and behavioural science</p> <p><strong><span><span><span>Professor Shankar Balasubramanian & Professor Rebecca Fitzgerald, University of Cambridge</span></span></span></strong><br /> Evaluation of G-quadruplex profiling for the early detection of oesophageal adenocarcinoma</p> <p><strong><span><span><span>Dr Ana Rio-Machin & Dr Kevin Rouault-Pierre, Queen Mary University of London </span></span></span></strong><br /> Deciphering the role of germline variants in the RNA-helicases to improve the early detection and management of familial MDS/AML patients</p> <p><strong><span><span><span>Dr Professor Richard Shaw & Professor Peter Weightman, University of Liverpool</span></span></span></strong><br /> Clinical and technical validation of infrared absorbance spectra to predict malignant transformation in oral potentially malignant disorders (OPMDs)</p> <p><strong><span><span><span>Dr Daniel Royston & Professor Jens Rittscher, University of Oxford</span></span></span></strong><br /> Integrating AI-based early detection and assessment of myeloproliferative neoplasms (MPN) into routine clinical pathways</p> <p><strong><span><span><span>Dr Lizhe Zhuang & Professor Rebecca Fitzgerald, University of Cambridge</span></span></span></strong><br /> Cross-platform study of clonal heterogeneity and microenvironmental niches in initiation and progression of Barrett’s oesophagus and oesophageal adenocarcinoma</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-primer-award">Primer Awards</a></h2> <p><strong><span><span><span>Dr Abish Stephen, Professor Keith Hunter & Dr Geraint Morgan, Queen Mary University of London</span></span></span></strong><br /> Volatile metabolomics for early detection of aerodigestive cancers</p> <p><strong><span><span><span>Dr Xin Yang, University of Cambridge</span></span></span></strong><br /> Improving endometrial cancer risk prediction for prevention and early detection</p> <p><strong><span><span><span>Professor David Klenerman & Professor Richard Mair, University of Cambridge</span></span></span></strong><br /> Sensitive detection of P53 aggregates in biofluids for the early detection of cancer</p> <p><strong><span><span><span>Dr Luca Panariello & Dr Adam Creamer, Imperial College London</span></span></span></strong><br /> MagnetoCrisprZyme sensor for quantification of circulating microRNA in primary care settings</p> <p><strong><span><span><span>Dr Marta Canel, University of Edinburgh</span></span></span></strong><br /> Validating new models to investigate the impact of mutational heterogeneity in the early detection of pancreatic cancer</p> <p><strong><span><span><span>Professor Neil Hunt, University of York</span></span></span></strong><br /> Ultrafast 2D-IR analysis of liquid biopsies for cancer detection</p> <p><strong><span><span><span>Dr Marek Palace, Dr Christian von Wagner & Dr Carlos Santos Barea , Liverpool John Moores University</span></span></span></strong><br /> Developing multimodal data-driven art-inspired bowel cancer-screening promotion messages</p> <p><strong><span><span><span>Dr Ljiljana Fruk, University of Cambridge</span></span></span></strong><br /> Senescence-detecting, urine-based nanobiosensor for early detection of lung cancer</p> <p><strong><span><span><span>Professor Trevor Graham & Dr Callum Gabbutt, Institute of Cancer Research</span></span></span></strong><br /> Sensitive and specific pan-cancer early detection using fluctuating methylation clocks</p> <p> </p> <h2>November 2022</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-programme-award">Programme Awards</a></h2> <p><strong><span><span><span>Professor Caroline Dive & Dr Phil Crosbie, University of Manchester</span></span></span></strong><br /> Development of a multi-modal liquid biopsy for the early detection of lung cancer</p> <p><strong><span><span><span>Professor Clare Turnbull, Institute of Cancer Research, Dr David Adams, Wellcome Sanger Institute, and Dr Greg Findlay, The Francis Crick Institute</span></span></span></strong><br /> Defining the compendium of pathogenic germline alleles in cancer susceptibility genes via multiplex assays of variant effect (CG-MAVE)</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-project-award">Project Awards</a></h2> <p><strong><span><span><span>Dr Jacqueline Shields, King's College London</span></span></span></strong><br /> Exploiting The Lymphatic System For Early Detection And Risk Stratification Biomarkers</p> <p><strong><span><span><span>Dr James Reading, Professor Sam Janes & Dr Maxine Tran, University College London</span></span></span></strong><br /> A multiomic T cell differentiation index (TEDI) for non-invasive early detection of lung and renal cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-primer-award">Primer Awards</a></h2> <p><strong><span><span><span>Dr Gwen Murphy, Imperial College London</span></span></span></strong><br /> Serologic biomarkers of stomach cancer precursor lesions</p> <p><strong><span><span><span>Dr James Yarmolinsky, University of Bristol</span></span></span></strong><br /> Using reverse Mendelian randomization to discover novel circulating biomarkers for early detection of cancer</p> <p><strong><span><span><span>Dr Emma Woodward, University of Manchester</span></span></span></strong><br /> ATLAS - eArly deTection in Li frAumeni Syndrome</p> <p><strong><span><span><span>Professor Paula Mendes, University of Birmingham</span></span></span></strong><br /> Using superselective glycan-binding nanoparticles to create a clinical assay for early ovarian cancer detection</p> <p><strong><span><span><span>Dr Patrick Kierkegaard, Imperial College London</span></span></span></strong><br /> Developing an equity-focused Target Product Profile for non-invasive biomarker tests tailored to support mobile testing outreach programmes to reduce cancer inequalities</p> <p> </p> <h2>May 2022</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-programme-award">Programme Awards</a></h2> <p paraeid="{4ea84fd4-6da7-4052-a5da-9fe0c128e8a7}{78}" paraid="1591291542"><strong>Professor Fiona Walter, Queen Mary, University of London, & Professor Stephen Pereira, University College London</strong><br /> CANDETECT: Accelerating detection of upper gastro-intestinal (UGI) cancers using a multi- cancer early detection platform in primary care</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-project-award">Project Awards</a></h2> <p paraeid="{4ea84fd4-6da7-4052-a5da-9fe0c128e8a7}{120}" paraid="1041023108"><strong>Professor Sam Janes, Dr Amy Webster and Professor Christina Thirlwell, University College London </strong><br /> Epi-ASCENT: The epigenetic landscape of screen-detected lung cancers</p> <p paraeid="{4ea84fd4-6da7-4052-a5da-9fe0c128e8a7}{120}" paraid="1041023108"><strong>Dr Rasha Abu-Eid, University of Aberdeen </strong><br /> Integrating Raman spectroscopy and digital pathology as a novel tool for objective grading of oral epithelial dysplasia</p> <p><strong>Dr Floor Christie-de Jong, University of Sunderland, & Professor Katie Robb, University of Glasgow</strong><br /> Improving uptake of breast, bowel and cervical cancer screening among Muslim women: a feasibility study of a peer-led, faith-based intervention</p> <h2><a href="/funding-for-researchers/our-funding-schemes/early-detection-and-diagnosis-primer-award">Primer Awards</a></h2> <p><strong>Dr Richard Hopkinson, University of Leicester</strong><br /> Detection of aldehyde cancer biomarkers by harnassing their carcinogenic reactivity</p> <p><strong>Dr Alexander Oldroyd, University of Manchester </strong><br /> The MyoScreen Study - Investigating the Utility of Liquid Biopsy as a Method of Early Detection of Idiopathic Inflammatory Myopathy-Associated Cancer</p> <p><strong>Dr Francesco Boccellato, University of Oxford </strong> <br /> Early detection of gastric cancer by the identification of functional markers driving pre- malignant alterations of the tissue</p> <p><strong>Dr Lauren Ford, Imperial College London </strong><br /> IntelligentToilet</p> <p><strong>Dr James Flanagan, Imperial College London </strong><br /> Combining diet and symptom management for earlier detection of cancer using transactional data</p> <p><strong>Dr Samantha Hiu Yan Ip, </strong><strong>University of Cambridge </strong><br /> Investigating transportability of cancer detection models across datasets and time using population-wide electronic health data </p> <p><strong>Dr Jennifer Heaney, University of Birmingham </strong><br /> Improving myeloma diagnosis using a simple rapid test</p> <p><strong>Dr Denitza Williams, Cardiff University </strong><br /> Novel decision support intervention to support choice in cervical screening modality</p> <p><strong>Dr Qiang Wang, University of Edinburgh </strong><br /> Towards in-vivo in-situ early lung cancer detection using fluorescence lifetime imaging endomicroscopy: a preliminary study on data-driven characterisation of lung cancer using label-free autofluorescence lifetime images on unstained lung cancer tissue</p> <p><strong>Dr Sarah Haywood-Small, Sheffield Hallam University</strong><br /> Vocs-box breathomics: early detection and diagnosis of mesothelioma</p> <p><strong>Dr Leonid Nikitenko, University of Hull </strong><br /> EARLY DIAPAC: EARLY DIAgnosis of PAncreatic Cancer by combined proteomics and genomics testing of pancreatic cyst fluid<br /> <br /> <strong>Dr Christopher Rowlands, Imperial College London </strong><br /> Cancer Led Optical Ultrasound Detection </p> <p><strong>Dr Christian von Wagner, University College London </strong><br /> Development and evaluation of a chatbot to support informed choice in the UK Bowel Cancer Screening Programmes</p> <p><strong>Professor Ferdia Gallagher, University of Cambridge </strong><br /> Early detection of structural and metabolic changes in small renal masses using advanced MRI to differentiate benign from malignant lesions</p> <p><strong>Dr Ardhendu Behera, Edge Hill University </strong><br /> LungHealth AI: Using AI to improve early detection and diagnosis of lung cancer</p> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading"> <h2 class="panel-title" id="Recentlyfundedawards3"> <a data-toggle="collapse" class="" data-parent="#accordion-Recentlyfundedawards" href="#collapseRecentlyfundedawards3"> Prevention and Population Research Committee </a> </h2> </div> <div id="collapseRecentlyfundedawards3" class="panel-collapse in"> <div class="panel-body"> <h2>May 2024</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Project Awards</a></h2> <p><strong>Professor Eve Roman & Dr Eleanor Kane, University of York</strong><br /> United Kingdom Childhood Cancer Study (UKCCS): a national population-based study examining the health of cancer survivors</p> <p><strong>Dr Emma Vincent, University of Bristol & Professor Javier Gonzalez, University of Bath</strong><br /> Does the biological response to ketogenesis influence colorectal cancer risk? – Exploring causality and mechanism.</p> <p><strong>Dr Helena Carreira, London School of Hygiene and Tropical Medicine</strong><br /> Associations between androgen deprivation therapies and adverse cardiovascular outcomes in men with prostate cancer: a population-based cohort study in England</p> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Biology to Prevention Awards</a></h2> <p><strong>Dr Luke Boulter, University of Edinburgh</strong><br /> Identifying and eradicating tumour-initiating cells in high-risk cholangiocarcinoma patients</p> <p><strong>Professor Ahmed Ahmed, University of Oxford</strong><br /> Developing a vaccine for ovarian cancer prevention</p> <p><strong>Dr Cassie Clarke, Cancer Research UK Scotland Institute</strong><br /> Exploiting pyrimidine metabolism as a cancer prevention and intervention strategy</p> <p><strong>Dr David Church & Professor Simon Leedham, University of Oxford</strong><br /> LynchVax – a precision prevention vaccination strategy for Lynch Syndrome (LS)</p> <p><strong>Professor Malcolm Dunlop, University of Edinburgh</strong><br /> Establishing the rationale to develop small molecule drugs to prevent polyps and cancer in Familial Adenomatous Polyposis</p> <p><strong>Professor Lesley Stark, University of Edinburgh</strong><br /> Use of spatial proteomics to dissect an emerging inflammatory pathway for targeted cancer prevention</p> <h2> </h2> <h2>November 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-programme-grants">Programme Awards</a></h2> <p><strong>Professor Christopher Bunce & Professor Mark Drayson, University of Birmingham</strong><br /> Prevention not cure: An interdisciplinary approach to preventing Myeloma</p> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Project Awards</a></h2> <p><strong>Professor Mark Hamer, University College London</strong><br /> The twenty-four hour physical behaviour spectrum and risk of cancer: The Prospective Physical Activity, Sitting and Sleep consortium (ProPASS)</p> <p><strong>Professor Catherine Harwood & Dr Rubeta Matin, Cardiff University</strong><br /> SPOT-IT: cutaneous SCC Prevention using tOpical Therapy in Immunosuppressed patienTs</p> <p><strong>Dr Laura Woods & Professor Linda Sharp, Newcastle University</strong><br /> Investigating deprivation-specific and ethnic inequalities in adherence to endocrine therapy in women with ER+ve breast cancer: can these explain disparities in survival?</p> <p><strong>Professor Rosalind Eeles, Institute of Cancer Research</strong><br /> IMPACT: Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in men at higher genetic risk and non-carriers – Long term follow up of the Mis-match Repair Gene Cohort</p> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Biology to Prevention Awards</a></h2> <p>Dr James Reading & Professor Sam Janes, University College London<br /> Targeting early T cell regulation to intercept lung squamous carcinogenesis</p> <p>Dr Seth Coffelt & Dr Joanne Edwards, University of Glasgow<br /> Investigating immunological prevention strategies for precursor lesions of colon cancer</p> <p>Professor Tim Elliott. Dr Kevin Litchfield & Professor Sarah Blagden, University of Oxford<br /> LungVax: Preventing lung cancer via targeting hotspot neoantigens with the ChAdOx vaccine platform</p> <p>Dr Stephanie May, University of Glasgow<br /> Targeting oncogene induced anti-apoptotic pathways for precision prevention in liver cancer</p> <p>Dr Sanne van Neervan & Professor Benjamin Simons, University of Cambridge<br /> The role of mutant cell competition and cooperation during field cancerization and intestinal adenoma development</p> <p>Dr Emma Allott, Queen's University Belfast<br /> Repurposing statins for precision prevention of PTEN-null prostate cancer</p> <p>Dr Yi Feng, University of Edinburgh<br /> Tracing somatic cell acquired oncogenic mutations from inception to investigate tissue environmental contribution to preneoplastic development</p> <p>Dr Matthew Rose-Zerilli, University of Southampton<br /> Harnessing the activities of gastro-intestinal innate immune cells for the prevention of oesophageal adenocarcinoma</p> <p>Dr Matthew Ford & Professor James Brenton, CRUK Cambridge Institute<br /> Exploring premalignant lesions of high-grade serous ovarian cancer and response to next generation PARP-inhibitors</p> <p> </p> <h2>May 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Project Awards</a></h2> <p><strong>Dr James Yarmolinsky, University of Bristol</strong><br /> Obesity and pancreatic cancer risk: leveraging genetic, observational, and molecular approaches to provide novel insights into causal intermediates to inform cancer prevention</p> <p>Professor Richard Martin, Professor Jenny Donovan, Professor Freddy Hamdy & Professor David Neal, University of Bristol<br /> Answering key questions needed to inform prostate cancer screening policy: long-term follow-up of the ProtecT (15-year) and CAP (18-year) randomised controlled trials.</p> <p>Professor Doug Easton, University of Cambridge<br /> Characterisation of novel breast cancer susceptibility genes through large-scale targeted sequencing</p> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Biology to Prevention Awards</a></h2> <p>Professor Walid Khaled & Dr Sara Pensa, University of Cambridge<br /> Targeting BRCA driven premalignant cellular changes in the breast</p> <p>Professor Kwee Yong, University College London<br /> Understanding and restoring NK cell (dys)function in smouldering myeloma to optimise intervention strategies to prevent development of multiple myeloma</p> <h2> </h2> <h2>November 2022</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Project Awards</a></h2> <h3>Renewing Programme</h3> <p><strong>Professor Amanda Cross, Imperial College London</strong><br /> Screening, Prevention and Diagnosis of Gastrointestinal Cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Project Awards</a></h2> <p><strong>Professor Chris Cardwell, Queen's University Belfast</strong><br /> Antibiotic use and survival from breast cancer</p> <p><strong>Dr Jamie Hartmann Boyce & Dr Nicola Lindson, University of Oxford</strong><br /> Synthesising evidence on e-cigarettes: two living systematic reviews exploring their efficacy and safety for smoking cessation, and how to stop using them</p> <p><strong>Dr Tom Dudding & Dr Barry Main, University of Bristol</strong><br /> Head and neck 5000 – Identifying factors affecting survival and secondary physical effects of treatment at 10 years</p> <p><strong>Dr Laura Woods, Newcastle University</strong><br /> Developing a screening engagement index (SEI) for England</p> <p><strong>Dr Toral Gathani, University of Oxford</strong><br /> The Associations of Ethnicity and Breast Cancer</p> <h2> </h2> <h2>May 2022</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-programme-grants">Programme Awards</a></h2> <p><strong>Professor Claudia Allemani and Professor Michel Coleman, London School of Hygiene and Tropical Medicine</strong><br /> Global surveillance of cancer survival (CONCORD-4): 20-year trends in survival from 22 adult cancers and all childhood cancers, for patients diagnosed during 2000-2019 or later</p> <h2><a href="/funding-for-researchers/our-funding-schemes/population-research-committee-prc-project-grants">Project Awards</a></h2> <p><strong>Dr Simon Lord and Professor Sarah Blagden, University of Oxford</strong><br /> Exploring metformin’s mechanisms of action in mTP53-driven cancers</p> <p><strong>Professor Shahid Khan and Professor Simon Rushbrook, Imperial College London</strong><br /> Asp-PSC: Effect of Aspirin on Reducing Cancer in Primary Sclerosing Cholangitis</p> <p><strong>Dr Crawford Moodie, University of Stirling</strong><br /> The Adult Tobacco Policy Survey: Understanding how smokers and ex-smokers respond to tobacco control policies in the UK</p> <p><strong>Professor Nicholas Timpson and Dr Vanessa Tan, University of Bristol</strong><br /> Role of directly measured metabolic profile as an intermediate between adiposity and endometrial cancer: triangulation of evidence from independent sources</p> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading"> <h2 class="panel-title" id="Recentlyfundedawards4"> <a data-toggle="collapse" class="" data-parent="#accordion-Recentlyfundedawards" href="#collapseRecentlyfundedawards4"> Research Careers Committee </a> </h2> </div> <div id="collapseRecentlyfundedawards4" class="panel-collapse in"> <div class="panel-body"> <h2>May 2024</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/senior-cancer-research-fellowship">Senior Cancer Research Fellowship</a></h2> <p><strong>Dr Bethan Psaila, University of Oxford</strong><br /> Combating Cancer in a Challenging Environment – The Malignant Bone Marrow Niche</p> <h2><a href="/funding-for-researchers/our-funding-schemes/advanced-clinician-scientist-fellowship">Advanced Clinical Science Fellowship</a></h2> <p><strong>Dr Richard Mair, Cancer Research UK Cambridge Institute</strong><br /> Identifying the mechanisms responsible for low- to high-grade transformation in IDH mutant astrocytoma</p> <h2><a href="/funding-for-researchers/our-funding-schemes/career-development-fellowship">Career Development Award</a></h2> <p><strong>Dr Heather Machado, University of Cambridge</strong><br /> Somatic evolution of CD8+ T cell tumour recognition, immune remodelling and immunotherapy response</p> <p><strong>Dr Haiyan Zheng, University of Bath</strong><br /> STEEP: Statistically Efficient Methods for Precision Medicine Trials</p> <h2><a href="/funding-for-researchers/our-funding-schemes/pre-doctoral-research-bursary">Pre-doctoral Research Bursary</a></h2> <p><strong>Dr Kishen Patel, University College London</strong><br /> Integrating ctDNA Whole Genome Sequencing with Volumetric Analysis in Stage 3 Non-small cell lung cancer: A Proof-of-Concept Study</p> <h2><a href="/funding-for-researchers/our-funding-schemes/postdoctoral-research-bursary-for-clinical-trainees">Postdoctoral Research Bursary</a></h2> <p><strong>Dr Meera Patel, University of Manchester</strong><br /> Determining the role of bacteria in peritoneal metastasis from colorectal cancer</p> <h2> </h2> <h2>November 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/career-establishment-award">Career Establishment Award</a></h2> <p><strong>Dr Zarnie Khadjesari, University of East Anglia</strong><br /> Preventing cancer and cancer disparities with weight-management support – using hospital patient records and electronic signposting (eSIGN)</p> <p><strong>Dr Luigi Ombrato, Queen Mary University of London</strong><br /> Controlling metastasis formation by inhibiting the crosstalk between different myeloid cells</p> <p><strong>Dr Nischalan Pillay, University College London</strong><br /> Neo-Sarc: Enhancing the clinical whole genome sequencing programme for patients with genomically complex sarcomas</p> <h2><a href="/funding-for-researchers/our-funding-schemes/career-development-fellowship">Career Development Award</a></h2> <p><strong>Dr Matthew Coelho, Wellcome Sanger Institute</strong><br /> Establishing the Genetic Landscape of Therapy Resistance in Lung Cancer with Gene Editing</p> <p><strong>Dr Anke Nijhuis, Imperial College London</strong><br /> Targeting RNA splicing as a novel therapeutic strategy in ovarian cancer</p> <p><strong>Dr Johan Vande Voorde, University of Glasgow </strong><br /> Leveraging microbial metabolism to improve clinical outcome in colorectal cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/pre-doctoral-research-bursary">Pre-doctoral Research Bursary</a></h2> <p><strong>Dr Thineskrishna Anbarasan, University of Oxford</strong><br /> Integrating Spatial Transcriptomics with Multiparametric MRI in Prostate Cancer</p> <p><strong>Dr Faiz Jabbar, Imperial College Healthcare NHS Trust</strong><br /> Investigating how non-mutagenic factors influence driver gene selection during cancer initiation</p> <p><strong>Dr Thurkaa Shanmugalingam, King's College London</strong><br /> Profiling circulating tumour cells in lobular breast cancer</p> <p><strong>Dr Daniel Hughes, University College London</strong><br /> Modelling chromosome 13 deletion in human myeloma cell lines for functional assessment</p> <h2><a href="/funding-for-researchers/our-funding-schemes/postdoctoral-research-bursary-for-clinical-trainees">Postdoctoral Research Bursary</a></h2> <p><strong>Dr Oliver Pickles, University of Birmingham</strong><br /> Establishing a Patient-Derived Explant (PDE/PDTF) Programme for Colorectal Cancer Liver Metastases to Enhance Responses to Immune Checkpoint Blockade</p> <p> </p> <h2>May 2023</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/senior-cancer-research-fellowship">Senior Cancer Research Fellowship</a></h2> <p><strong>Dr Ivana Bjedov, University College London</strong><br /> Defining novel mechanisms of selective radioprotection to improve cancer radiotherapy</p> <p><strong>Dr Andrew Blackford, University of Oxford</strong><br /> Genetic and functional interactions of RecQ helicases in cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/advanced-clinician-scientist-fellowship">Advanced Clinical Science Fellowship</a></h2> <p><strong>Dr Amaya Viros, Cancer Research UK Manchester Institute</strong><br /> Melanoma metabolic programmes of metastasis, tropism and immunotherapy response by anatomic site</p> <h2><a href="/funding-for-researchers/our-funding-schemes/career-establishment-award">Career Establishment Award</a></h2> <p><strong>Dr Mirjana Efremova, Queen Mary, University London</strong><br /> Characterising the cellular state transitions mediating colorectal cancer metastasis</p> <h2><a href="/funding-for-researchers/our-funding-schemes/clinician-scientist-fellowship">Clinician Scientist Award</a></h2> <p><strong>Dr Sarah Aitken, University of Cambridge</strong><br /> Identifying image biomarkers in the spatial evolution of liver cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/pre-doctoral-research-bursary">Pre-doctoral Research Bursary</a></h2> <p><strong>Dr Khaylen Mistry, University of East Anglia</strong><br /> Molecular characteristics and outcomes of melanoma in England: a national cohort study</p> <p><strong>Dr Riccardo Masina, University of Cambridge</strong><br /> Modelling drug response with multi-omics using machine learning in PDTC high-throughput drug screening</p> <p><strong>Dr Daniele Scotto, University of Nottingham</strong><br /> Characterisation of myeloid-derived suppressor cells as a therapeutic target in glioblastoma multiforme</p> <p><strong>Dr Georgios Solomou, Cambridge University Hospitals NHS Trust</strong><br /> Delineating glioblastoma cell state transitions during cell invasion using a patient-derived glioblastoma ex vivo organoid model (GBO)</p> <h2><a href="/funding-for-researchers/our-funding-schemes/postdoctoral-research-bursary-for-clinical-trainees">Postdoctoral Research Bursary</a></h2> <p><strong>Dr Thomas Hubbard, University of Exeter</strong><br /> Investigating the changes in breast cancer post neoadjuvant chemotherapy with Raman Spectroscopy</p> <p><strong>Dr Akshay Patel, University of Birmingham</strong><br /> Investigating Regulatory B cells as determinants of immune-related adverse events following checkpoint blockade therapy</p> <p><strong>Dr Robert Morgan, University of Manchester</strong><br /> Exploiting a Living Biobank to develop targeted therapies for platinum-resistant ovarian cancer</p> <p> </p> <h2>November 2022</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/career-establishment-award">Career Establishment Award</a></h2> <p><strong>Dr Barrie Peck, Queen Mary, University of London</strong><br /> Understanding and exploiting Acetyl-CoA metabolism in Small Cell Lung Cancer</p> <h2><a href="/funding-for-researchers/our-funding-schemes/senior-cancer-research-fellowship">Senior Cancer Research Fellowship</a></h2> <p><strong>Dr J<span><span><span>ö</span></span></span>rg Mansfeld, Institute of Cancer Research</strong><br /> Discovery and functional investigation of how ROS can regulate the cell cycle</p> <h2><a href="/funding-for-researchers/our-funding-schemes/clinician-scientist-fellowship">Clinician Scientist Fellowship</a></h2> <p><strong>Dr Ayesha Noorani, Wellcome Sanger Institute </strong><br /> Mapping the clonal dynamics and somatic mutations of the human oesophagus during disease, development and carcinogenesis</p> <p><strong>Dr Sung Pil Hong, Imperial College London</strong><br /> Single-cell multi-omic profiling of intratumoral heterogeneity to tackle oesophageal cancer cell adaptation to chemotherapy</p> <p><strong>Dr Gurdeep Mannu, University of Oxford</strong><br /> Pre-invasive and Invasive breast cancer: from risk factors to optimal treatment</p> <h2> </h2> <h2>May 2022</h2> <h2><a href="/funding-for-researchers/our-funding-schemes/career-establishment-award">Career Establishment Award</a></h2> <p><strong>Dr Manavendra Pathania, University of Cambridge </strong><br /> The role of partner mutations in histone-mutant paediatric glioma</p> <p><strong>Dr Oscar Rueda, University of Cambridge</strong><br /> A statistical dynamic system for breast cancer prognosis and patient monitoring</p> <h2><a href="/funding-for-researchers/our-funding-schemes/senior-cancer-research-fellowship">Senior Cancer Research Fellowship</a></h2> <p><strong>Dr Sophie Acton, University College London</strong><br /> Harnessing the lymphoid tissue niche to boost anti-tumour immunity </p> <h2><a href="/funding-for-researchers/our-funding-schemes/clinician-scientist-fellowship">Clinician Scientist Fellowship</a></h2> <p><strong>Dr Ehsan Ghorani, Imperial College London </strong><br /> Deciphering mechanisms of immune dysfunction and immunotherapy sensitivity in gestational trophoblastic neoplasia </p> <h2><a href="/funding-for-researchers/our-funding-schemes/advanced-clinician-scientist-fellowship">Advanced Clinician Scientist Fellowship</a></h2> <p><strong>Dr Jyoti Nangalia, Wellcome Sanger Institute</strong><br /> Deciphering timelines and trajectories to blood cancer </p> </div> </div> </div> </div> </div> </div> </div> <div id="panel-2"> <div class="panel-pane pane-fieldable-panels-pane pane-uuid-075db7d4-b012-41e2-bcb1-ad241cff56f5 pane-promolh white-panel" > <h2 class="pane-title">More facts and figures about our research funding</h2> <div class="pane-content"> <div class="fieldable-panels-pane">  <div class="field field-type-image"> <div class="field-item"><img typeof="foaf:Image" src="https://www.cancerresearchuk.org/sites/default/files/styles/cruk_no_style/public/cruk_network_map_fy1718_final_a4_version-440px-crop.jpg?itok=ejtUwUPB" alt="Facts and figures about our research funding" title="Facts and figures about our research funding" /></div> </div> <div class="field field-type-text-with-summary"> <div class="field-item"><p>Find out more about how and where we supported research in the last year with our interactive map and infographics.</p> </div> </div> <div class="field field-type-link-field"> <div class="field-item"><a href="https://www.cancerresearchuk.org/funding-for-researchers/facts-and-figures-about-our-research-funding" class="more">Explore our funding facts and figures</a></div> </div> </div> </div> </div> </div> </div> <div class="column-right col-md-3 col-sm-4 col-xs-12" > <div id="panel-3"> <div class="panel-pane pane-node pane-promo" > <h2 class="pane-title"> <a href="/funding-for-researchers/applying-for-funding/funding-committees">Funding committees</a></h2> <div class="pane-content">  <article class="node node-standard-content-type " about="/funding-for-researchers/applying-for-funding/funding-committees" typeof="sioc:Item foaf:Document" role="article"> <h2><a href="/funding-for-researchers/applying-for-funding/funding-committees" rel="bookmark"></a></h2> <span property="dc:title" content="" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-type-text-with-summary"> <div class="field-item" property="content:encoded"><p>Our committees oversee the peer review of applications for CRUK funding and support delivery of our strategic priorities.</p> <p class="more"><a href="/funding-for-researchers/applying-for-funding/funding-committees">Read about our decision making process</a></p></div> </div> <span property="foaf:name" content="dunckl01" class="rdf-meta element-hidden"></span> </div> </article> </div> </div> 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