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<!doctype html> <html lang="pt"> <head> <title>Hepatotoxic Effects of Acanthaster planci Envenomation: A Ra | 1099644</title> <meta name="keywords" content="Muhammad Z Arif, Dania Afzal, Sebastian Hernandez, James F Holmes, Timothy E Albertson, "/> <meta name="description" content="Introduction: Acanthaster planci (crown-of-thorns starfish) is a known coral reef predator found in tropical waters. Despite increasing human encounters..1099644"/> <meta name="citation_publisher" content="Longdom Publishing SL" /> <meta name="citation_journal_title" content="Jornal de Toxicologia Cl铆nica"> <meta name="citation_title" content="Hepatotoxic Effects of Acanthaster planci Envenomation: A Rare Case with Review of Literature on Crown-of-Thorns Starfish Sting"> <meta name="citation_author" content="Muhammad Z Arif" /> <meta name="citation_author" content="Dania Afzal" /> <meta name="citation_author" content="Sebastian Hern" /> <meta name="citation_author" content="ez" /> <meta name="citation_author" content="James F Holmes" /> <meta name="citation_author" content="Timothy E Albertson" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="14"> <meta name="citation_issue" content="5"> <meta name="citation_abstract" content="Introduction: Acanthaster planci (crown-of-thorns starfish) is a known coral reef predator found in tropical waters. Despite increasing human encounters, there is limited documentation on the hepatotoxic effects of Acanthaster planci (A. planci) envenomation. We present a rare case of hepatotoxicity following envenomation, contributing to the scarce literature. Case summary: A 70-year-old male presented with immediate sharp pain after brushing against the crown of an A. planci during a scuba diving trip in Moorea Island, French Polynesia. Initial evaluation in a local Emergency Department (ED) revealed febrile convulsive episodes, and the patient was subsequently discharged. He was readmitted with elevated liver enzymes Alanine Aminotransferase (ALT) 650 U/L, Aspartate Aminotransferase (AST) 550 U/L), and was treated with antibiotics and tetanus prophylaxis. On returning to the USA, further labs showed persistent hepatotoxicity (ALT 607 U/L, AST 310 U/L) and retained spines in his left leg. The patient was managed with N-Acetyl Cysteine (NAC) and antibiotics (doxycycline, and trimethoprim-sulfamethoxazole), with improvement in liver function, but Alkaline Phosphatase (ALP) remained elevated. Surgical debridement was deferred. The patient is under outpatient follow-up with no residual symptoms. Discussion: The venom of A. planci contains asterosaponins, toxins with known hepatotoxic effects in animal models. While only two human cases have been reported, this case further highlights the potential for hepatotoxicity and the challenges in managing retained spines and systemic effects. Surgical debridement may not always be required if significant clinical improvement is seen. Conclusion: A. planci envenomation can lead to significant hepatotoxicity. Proper wound care, antibiotic coverage, and monitoring of liver function are essential. 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href="https://portuguese.longdom.org/chemistry-journals.html" title="Clique aqui">Qu铆mica</a><br> </nav> </div> </div>  </aside> <div class="col-12 col-sm-9"> <h2 class="heading-1">Abstrato</h2> <h3 class="">Hepatotoxic Effects of <i>Acanthaster planci</i> Envenomation: A Rare Case with Review of Literature on Crown-of-Thorns Starfish Sting</h3> <p> <i class="fas fa-user"></i> Muhammad Z Arif, Dania Afzal, Sebastian Hernandez, James F Holmes, Timothy E Albertson </p> <p><strong>Introduction:</strong> Acanthaster planci (crown-of-thorns starfish) is a known coral reef predator found in tropical waters. Despite increasing human encounters, there is limited documentation on the hepatotoxic effects of Acanthaster planci (A. planci) envenomation. We present a rare case of hepatotoxicity following envenomation, contributing to the scarce literature.</p> <p> <strong>Case summary:</strong> A 70-year-old male presented with immediate sharp pain after brushing against the crown of an A. planci during a scuba diving trip in Moorea Island, French Polynesia. Initial evaluation in a local Emergency Department (ED) revealed febrile convulsive episodes, and the patient was subsequently discharged. He was readmitted with elevated liver enzymes Alanine Aminotransferase (ALT) 650 U/L, Aspartate Aminotransferase (AST) 550 U/L), and was treated with antibiotics and tetanus prophylaxis. On returning to the USA, further labs showed persistent hepatotoxicity (ALT 607 U/L, AST 310 U/L) and retained spines in his left leg. The patient was managed with N-Acetyl Cysteine (NAC) and antibiotics (doxycycline, and trimethoprim-sulfamethoxazole), with improvement in liver function, but Alkaline Phosphatase (ALP) remained elevated. Surgical debridement was deferred. The patient is under outpatient follow-up with no residual symptoms.</p> <p> <strong>Discussion:</strong> The venom of A. planci contains asterosaponins, toxins with known hepatotoxic effects in animal models. While only two human cases have been reported, this case further highlights the potential for hepatotoxicity and the challenges in managing retained spines and systemic effects. Surgical debridement may not always be required if significant clinical improvement is seen.</p> <p> <strong>Conclusion: </strong>A. planci envenomation can lead to significant hepatotoxicity. Proper wound care, antibiotic coverage, and monitoring of liver function are essential. Further studies are needed to determine the role of NAC, surgical intervention, and long-term follow-up in these patients.</p> <div class="alert alert-info text-left"><b>Isen莽茫o de responsabilidade:</b> Este resumo foi traduzido com recurso a ferramentas de intelig锚ncia artificial e ainda n茫o foi revisto ou verificado.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Compartilhe este artigo</a> <a title="Clique aqui" target="_blank" href="https://www.facebook.com/sharer.php?u=https://portuguese.longdom.org/abstract/hepatotoxic-effects-of-iacanthaster-plancii-envenomation-a-rare-case-with-review-of-literature-on-crownofthorns-starfish-1099644.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Clique aqui" target="_blank" href="https://twitter.com/share?url=https://portuguese.longdom.org/abstract/hepatotoxic-effects-of-iacanthaster-plancii-envenomation-a-rare-case-with-review-of-literature-on-crownofthorns-starfish-1099644.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Clique aqui" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://portuguese.longdom.org/abstract/hepatotoxic-effects-of-iacanthaster-plancii-envenomation-a-rare-case-with-review-of-literature-on-crownofthorns-starfish-1099644.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Clique aqui" target="_blank" href="https://plus.google.com/share?url=https://portuguese.longdom.org/abstract/hepatotoxic-effects-of-iacanthaster-plancii-envenomation-a-rare-case-with-review-of-literature-on-crownofthorns-starfish-1099644.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Links de conte煤do</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://portuguese.longdom.org/privacy-policy.html" title="Clique aqui">pol铆tica de Privacidade</a></li> <li><a class="" href="https://portuguese.longdom.org/terms-conditions.html" title="Clique aqui">termos e Condi莽玫es</a></li> <li><a class="" href="https://portuguese.longdom.org/authors-reviewers-editors.html" title="Clique aqui">Autores, Revisores e Edi莽茫o</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contato Longdom</h4> <p><strong>Grupo Longdom SA</strong><br /> Avenida Roger Vandendriessche,<br /> 18, 1150 Bruxelas, B茅lgica<br /> Telefone: +442038085340<br /> <strong>E-mail:</strong> <a class="white" href="mailto:info@longdom.org" title="Clique aqui">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Conectar</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Clique aqui" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Clique aqui" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="Clique aqui" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="Clique aqui" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>direito autoral © 2024 <a href="https://portuguese.longdom.org/" title="Clique aqui" class="white">Longdom Publishing SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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