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UCLA-led study develops a wearable sensor that could guide precision drug dosing - Life Sciences
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develops a wearable sensor that could guide precision drug dosing</span></span></div> </div> </div> <header class="entry-header ast-no-thumbnail"> <h1 class="entry-title" itemprop="headline">UCLA-led study develops a wearable sensor that could guide precision drug dosing</h1> </header> <!-- .entry-header --> <div class="entry-content clear" itemprop="text"> <p><span style="font-family: helvetica, arial, sans-serif"><img fetchpriority="high" decoding="async" class="alignnone size-full wp-image-13524" src="https://lifesciences.ucla.edu/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA.png" alt="" width="12276" height="8184" srcset="https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA.png 12276w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA-300x200.png 300w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA-1030x687.png 1030w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA-768x512.png 768w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA-1536x1024.png 1536w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA-2048x1365.png 2048w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA-1500x1000.png 1500w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA-705x470.png 705w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/MicroneedleonafingerUCLA-802x535.png 802w" sizes="(max-width: 12276px) 100vw, 12276px" /></span></p> <p><span style="font-family: helvetica, arial, sans-serif"><strong><span style="font-size: 10pt">UCLA Life Sciences | December 7, 2022</span></strong></span></p> <p> </p> <p><span style="font-family: helvetica, arial, sans-serif">A collaborative team of UCLA researchers are developing a <a href="https://newsroom.ucla.edu/releases/wearable-sensor-precision-drug-dosing">wearable sensor</a> that could monitor levels of drugs and metabolites within a patient – and tailor drug-dosing to the specific and real-time needs of that individual.</span></p> <p><span style="font-family: helvetica, arial, sans-serif">Here, <a href="https://collerlab.dgsom.ucla.edu/pages/current_members">Hilary Coller,</a> a Life Sciences professor and collaborator on the project, provides an overview of this research, and shares how she got involved.</span></p> <p style="text-align: center"> <p><img decoding="async" class="wp-image-13546 aligncenter" src="https://lifesciences.ucla.edu/wp-content/uploads/sites/61/2023/06/Coller-Jelinek.png" alt="" width="557" height="388" srcset="https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/Coller-Jelinek.png 1452w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/Coller-Jelinek-300x209.png 300w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/Coller-Jelinek-1030x718.png 1030w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/Coller-Jelinek-768x535.png 768w, https://wp-misc.lifesci.ucla.edu/life-sciences/wp-content/uploads/sites/61/2023/06/Coller-Jelinek-705x491.png 705w" sizes="(max-width: 557px) 100vw, 557px" /></p> <p style="text-align: center"><span style="font-family: helvetica, arial, sans-serif;font-size: 10pt">UCLA Life Science Researchers</span></p> <p> </p> <p><span style="font-family: helvetica, arial, sans-serif"><strong>Q: Would you briefly describe what’s most exciting about this wearable sensor?</strong></span></p> <p><span style="font-family: helvetica, arial, sans-serif">A: The technology being developed in the <a href="https://www.i2bl.org/">Emaminejad lab</a> is extremely exciting, and has enormous potential. The patches they’re developing could provide doctors with real-time information on how individual patients are metabolizing drugs, and whether specific metabolites have accumulated above a safe level. These sensors have the potential to become the standard-of-care after drugs are administered.</span></p> <p> </p> <p><span style="font-family: helvetica, arial, sans-serif"><strong>Q: As a collaborator, how were you involved in this research?</strong></span></p> <p><span style="font-family: helvetica, arial, sans-serif">A: Professor Emaminejad’s laboratory is developing a wearable sensor that can continuously record the concentrations of different molecules in the body. Members of my lab, led by research associate David Jelinek, Ph.D., have been collaborating to test the biological feasibility of the microneedles used in these sensors. We conducted tests to see whether the components, or the needles themselves, result in cell death. The results provide valuable information on whether the sensors are safe for human cells.</span></p> <p> </p> <p><span style="font-family: helvetica, arial, sans-serif"><strong>Q: How did this collaboration come about?</strong></span></p> <p><span style="font-family: helvetica, arial, sans-serif">A: Professor Emaminejad and I initially met through our mutual interest in understanding how wounds heal. We were both interested in learning the metabolic aspects of wound healing in pressure ulcers, and other pathologies that result in a failure to heal. Our labs have been working together to understand the changes that occur during the wound healing process. In addition to drug levels in patients, we are also interested in how the levels of their different metabolites change over time. Such information could be extremely valuable, for instance, in identifying patients who require immediate attention, or those who show signs of metabolic distress, for instance, from an invisible but progressing pressure ulcer.</span></p> <p> </p> <p><span style="font-family: helvetica, arial, sans-serif"><strong>Q: How does this research align with the research you do?</strong></span></p> <p><span style="font-family: helvetica, arial, sans-serif">A: My laboratory has been studying the changes that occur, as cells transition between proliferating and non-dividing, quiescent states. Our particular focus is on the proliferating and quiescent states of skin cells, called fibroblasts. Fibroblasts are important in organizing the wound healing response. To understand wound healing, we’ve been collecting cells from healing and non-healing wounds of different patients to better understand the metabolic aspects of wound healing– in pressure ulcers, and other pathologies that involve a failure to heal.</span></p> <p> </p> <p><span style="font-family: helvetica, arial, sans-serif">Read more in this UCLA Newsroom article: <a href="https://newsroom.ucla.edu/releases/wearable-sensor-precision-drug-dosing">https://newsroom.ucla.edu/releases/wearable-sensor-precision-drug-dosing</a></span></p> </div><!-- .entry-content .clear --> </article><!-- #post-## --> </main><!-- #main --> </div><!-- #primary --> </div> <!-- ast-container --> </div><!-- #content --> <footer class="site-footer" id="colophon" itemtype="https://schema.org/WPFooter" itemscope="itemscope" itemid="#colophon"> <div class="site-primary-footer-wrap ast-builder-grid-row-container site-footer-focus-item ast-builder-grid-row-3-equal ast-builder-grid-row-tablet-3-equal ast-builder-grid-row-mobile-full ast-footer-row-stack ast-footer-row-tablet-stack ast-footer-row-mobile-stack" data-section="section-primary-footer-builder"> <div class="ast-builder-grid-row-container-inner"> <div class="ast-builder-footer-grid-columns site-primary-footer-inner-wrap ast-builder-grid-row"> <div class="site-footer-primary-section-1 site-footer-section site-footer-section-1"> <div class="footer-widget-area widget-area site-footer-focus-item ast-footer-html-1" data-section="section-fb-html-1"> <div class="ast-header-html inner-link-style-"><div class="ast-builder-html-element"><p><img class="ucla-dept-footer__logo" src="/wp-content/themes/ucla-astra/assets/logo-ucla.svg" alt="UCLA Logo" /></p> <p> </p> </div></div> </div> </div> <div class="site-footer-primary-section-2 site-footer-section site-footer-section-2"> </div> <div class="site-footer-primary-section-3 site-footer-section site-footer-section-3"> </div> </div> </div> </div> <div class="site-below-footer-wrap ast-builder-grid-row-container site-footer-focus-item ast-builder-grid-row-full ast-builder-grid-row-tablet-full ast-builder-grid-row-mobile-full ast-footer-row-inline ast-footer-row-tablet-stack ast-footer-row-mobile-stack" data-section="section-below-footer-builder"> <div class="ast-builder-grid-row-container-inner"> <div class="ast-builder-footer-grid-columns site-below-footer-inner-wrap ast-builder-grid-row"> <div class="site-footer-below-section-1 site-footer-section site-footer-section-1"> <div class="ast-builder-layout-element ast-flex site-footer-focus-item ast-footer-copyright" data-section="section-footer-builder"> <div class="ast-footer-copyright"><p>© 2025 Regents of the <strong>University of California</strong></p> </div> </div> <div class="footer-widget-area widget-area site-footer-focus-item" data-section="section-footer-menu"> </div> <div class="ast-builder-layout-element ast-flex site-footer-focus-item" data-section="section-fb-social-icons-1"> <div class="ast-footer-social-1-wrap ast-footer-social-wrap"><div class="footer-social-inner-wrap element-social-inner-wrap social-show-label-false ast-social-color-type-custom ast-social-stack-none ast-social-element-style-filled"><a href="https://www.facebook.com/UCLA/" aria-label="Facebook" target="_blank" rel="noopener noreferrer" style="--color: #557dbc; 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