PIPELINE — Vigil Neuro

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sqs-block-html" data-block-type="2" id="block-d634a225126763d64ad5"><div class="sqs-block-content"> <div class="sqs-html-content"> <h1 style="white-space:pre-wrap;"> PIPELINE</h1> </div> </div></div></div></div></div> </div> <figure class="Index-page-image" data-parallax-image-wrapper> <img data-src="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1605171647493-X0BMIXKX0UG50ZYGGHIB/pipeline-candidates.jpg" data-image="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1605171647493-X0BMIXKX0UG50ZYGGHIB/pipeline-candidates.jpg" data-image-dimensions="1920x1080" data-image-focal-point="0.6622758873033296,0.4792112361640778" alt="pipeline-candidates.jpg" data-load="false" alt="" /> </figure> </section> <section id="calloutnew" class="Index-page Index-page--has-image" data-parallax-original-element data-collection-id="61a54b6886659c7cf28af59f" data-parallax-id="61a54b6886659c7cf28af59f" data-edit-main-image="Background"> <div class="Index-page-content sqs-alternate-block-style-container"> <div class="sqs-layout sqs-grid-12 columns-12" data-type="page" data-updated-on="1736975196034" id="page-61a54b6886659c7cf28af59f"><div class="row sqs-row"><div class="col sqs-col-12 span-12"><div class="row sqs-row"><div class="col sqs-col-3 span-3"><div class="sqs-block image-block sqs-block-image" data-block-type="5" id="block-b4df1cca15e817bf2490"><div class="sqs-block-content"> <div class=" image-block-outer-wrapper layout-caption-hidden design-layout-inline combination-animation-none individual-animation-none individual-text-animation-none " data-test="image-block-inline-outer-wrapper" > <figure class=" sqs-block-image-figure intrinsic " style="max-width:1000px;" > <div class="image-block-wrapper" data-animation-role="image" > <div class="sqs-image-shape-container-element has-aspect-ratio " style=" position: relative; padding-bottom:86.4000015258789%; overflow: hidden;-webkit-mask-image: -webkit-radial-gradient(white, black); " > <img data-stretch="false" data-src="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png" data-image="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png" data-image-dimensions="1000x864" data-image-focal-point="0.5,0.5" alt="" data-load="false" elementtiming="system-image-block" src="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png" width="1000" height="864" alt="" sizes="(max-width: 640px) 100vw, (max-width: 767px) 25vw, 25vw" style="display:block;object-fit: cover; width: 100%; height: 100%; object-position: 50% 50%" onload="this.classList.add("loaded")" srcset="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png?format=100w 100w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png?format=300w 300w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png?format=500w 500w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png?format=750w 750w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png?format=1000w 1000w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png?format=1500w 1500w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606753986462-DA1QE8WXSW03KURRYPKB/PR1RK0-constrained.-trio.png?format=2500w 2500w" loading="lazy" decoding="async" data-loader="sqs"> </div> </div> </figure> </div> </div></div></div><div class="col sqs-col-9 span-9"><div class="sqs-block html-block sqs-block-html" data-block-type="2" id="block-9f6b1b91f361d791c04a"><div class="sqs-block-content"> <div class="sqs-html-content"> <h2 data-rte-preserve-empty="true" style="white-space:pre-wrap;"></h2><h2 style="white-space:pre-wrap;">We are developing a pipeline of innovative microglial therapeutics across modalities of biologics and small molecules, which can be developed for multiple neurodegenerative diseases</h2> </div> </div></div></div></div></div></div></div> </div> <figure class="Index-page-image" data-parallax-image-wrapper> <img data-src="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1605186958486-MOPFOP8E9X2X09T1NFIN/orange-background.jpg" data-image="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1605186958486-MOPFOP8E9X2X09T1NFIN/orange-background.jpg" data-image-dimensions="1920x1080" data-image-focal-point="0.5,0.5" alt="orange-background.jpg" data-load="false" alt="" /> </figure> </section> <section id="programsnew" class="Index-page Index-page--has-image" data-parallax-original-element data-collection-id="62ed5cfabfe9d0219bcbe027" data-parallax-id="62ed5cfabfe9d0219bcbe027" data-edit-main-image="Background"> <div class="Index-page-content sqs-alternate-block-style-container"> <div class="sqs-layout sqs-grid-12 columns-12" data-type="page" data-updated-on="1737127398647" id="page-62ed5cfabfe9d0219bcbe027"><div class="row sqs-row"><div class="col sqs-col-12 span-12"><div class="sqs-block image-block sqs-block-image" data-block-type="5" id="block-2025bbe05cc4f2be02d9"><div class="sqs-block-content"> <div class=" image-block-outer-wrapper layout-caption-below design-layout-inline combination-animation-slide-up individual-animation-none individual-text-animation-none " data-test="image-block-inline-outer-wrapper" > <figure class=" sqs-block-image-figure intrinsic " style="max-width:1500px;" > <button class=" sqs-block-image-button lightbox " data-description="<p class="" style="white-space:pre-wrap;">CLICK TO ENLARGE</p>" data-lightbox-theme="light" > <span class="v6-visually-hidden">View fullsize</span> <div class="image-block-wrapper" data-animation-role="image" data-animation-override > <div class="sqs-image-shape-container-element has-aspect-ratio " style=" position: relative; padding-bottom:36.06666564941406%; overflow: hidden;-webkit-mask-image: -webkit-radial-gradient(white, black); " > <img data-stretch="false" data-src="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png" data-image="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png" data-image-dimensions="1500x541" data-image-focal-point="0.5,0.5" alt="Vigil Pipeline" data-load="false" elementtiming="system-image-block" src="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png" width="1500" height="541" alt="" sizes="(max-width: 640px) 100vw, (max-width: 767px) 100vw, 100vw" style="display:block;object-fit: cover; width: 100%; height: 100%; object-position: 50% 50%" onload="this.classList.add("loaded")" srcset="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png?format=100w 100w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png?format=300w 300w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png?format=500w 500w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png?format=750w 750w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png?format=1000w 1000w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png?format=1500w 1500w, https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/865eda8c-63d1-4cd3-ad11-a278c52455ae/Vigil_Pipeline_2023_NOV-2.png?format=2500w 2500w" loading="lazy" decoding="async" data-loader="sqs"> </div> </div> </button> <figcaption class="image-caption-wrapper"> <div class="image-caption"><p class="" style="white-space:pre-wrap;">CLICK TO ENLARGE</p></div> </figcaption> </figure> </div> </div></div><div class="sqs-block horizontalrule-block sqs-block-horizontalrule" data-block-type="47" id="block-6d07342e54c769d7e1df"><div class="sqs-block-content"><hr /></div></div><div class="sqs-block html-block sqs-block-html" data-block-type="2" id="block-yui_3_17_2_1_1733944559868_12297"><div class="sqs-block-content"> <div class="sqs-html-content"> <h3 style="white-space:pre-wrap;"><strong>Iluzanebart (VGL101) </strong>–<strong> </strong>a fully human monoclonal antibody TREM2 agonist</h3><p class="" style="white-space:pre-wrap;">Iluzanebart is currently being studied in a Phase 2 proof-of-concept (PoC) trial in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare and fatal neurodegenerative disease</p><p class="" style="white-space:pre-wrap;"><strong>Expected Mechanism of Action of Iluzanebart</strong></p> </div> </div></div><div class="row sqs-row"><div class="col sqs-col-4 span-4"><div class="sqs-block spacer-block sqs-block-spacer sized vsize-1" data-block-type="21" id="block-yui_3_17_2_1_1736973412424_35715"><div class="sqs-block-content"> </div></div></div><div class="col sqs-col-4 span-4"><div class="sqs-block video-block sqs-block-video" data-block-json="{"blockAnimation":"none","layout":"caption-hidden","overlay":false,"description":{"html":"<p data-rte-preserve-empty=\"true\" style=\"white-space:pre-wrap;\"></p>"},"hSize":null,"floatDir":null,"isOldBlock":false,"url":"","resolvedBy":"native","nativeVideo":"6759e526ae0d3d61b71065c0"}" data-block-type="32" id="block-yui_3_17_2_1_1733944559868_5307"><div class="sqs-block-content"><div class="intrinsic" style="max-width:100%"><div class="embed-block-wrapper " style="padding-bottom:0.5625%;"><div class="sqs-native-video" data-config-block-id="yui_3_17_2_1_1733944559868_5307" data-config-settings="null" data-config-thumbnail="null" data-config-video="{"id":"6759e526ae0d3d61b71065c0","recordType":61,"addedOn":1733944614549,"updatedOn":1733945180244,"workflowState":1,"authorId":"654e7771765ed734c8e8597d","systemDataId":"b8d4b181-8356-496e-a0c9-b9aac15208d5","systemDataVariants":"1920:1080,640:360","systemDataSourceType":"mp4","filename":"vigil_neuro (1080p).mp4","body":null,"likeCount":0,"commentCount":0,"publicCommentCount":0,"commentState":1,"unsaved":false,"author":{"id":"654e7771765ed734c8e8597d","displayName":"Julia Keefe","firstName":"Julia","lastName":"Keefe","bio":""},"contentType":"video/mp4","structuredContent":{"_type":"SqspHostedVideo","videoCodec":"h264","audioCodec":"aac","alexandriaUrl":"https://video.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/b8d4b181-8356-496e-a0c9-b9aac15208d5/{variant}","alexandriaLibraryId":"5f77665fce2a6e2e65763cf0","aspectRatio":1.7777777777777777,"durationSeconds":137.833333},"videoCodec":"h264","audioCodec":"aac","alexandriaUrl":"https://video.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/b8d4b181-8356-496e-a0c9-b9aac15208d5/{variant}","alexandriaLibraryId":"5f77665fce2a6e2e65763cf0","aspectRatio":1.7777777777777777,"durationSeconds":137.833333,"items":[],"pushedServices":{},"pendingPushedServices":{},"usageId":"1042e24e-2a78-39ad-b3bd-ccb626190323","originalSize":"1920:1080","recordTypeLabel":"sqsp-hosted-video"}"><div class="native-video-player"></div></div></div></div></div></div></div><div class="col sqs-col-4 span-4"><div class="sqs-block spacer-block sqs-block-spacer sized vsize-1" data-block-type="21" id="block-yui_3_17_2_1_1736973412424_25410"><div class="sqs-block-content"> </div></div></div></div><div class="sqs-block horizontalrule-block sqs-block-horizontalrule" data-block-type="47" id="block-yui_3_17_2_1_1733944559868_15441"><div class="sqs-block-content"><hr /></div></div><div class="sqs-block markdown-block sqs-block-markdown" data-block-type="44" id="block-7f43181d89d1ba39e93b"><div class="sqs-block-content"><p><span data-preserve-html-node="true" style="color:#FCB017"><strong data-preserve-html-node="true" p="">About adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)</strong></span></p> <span data-preserve-html-node="true" style="color:#737373">ALSP is a rare, inherited, autosomal dominant neurological disease with high penetrance. ALSP is caused by a loss-of-function mutation in the colony stimulating factor 1 receptor (CSF1R), a receptor that shares a common downstream signaling pathway with TREM2 and affects an estimated 19,000 people in the U.S., and an estimated 29,000 in Europe and Japan. <br data-preserve-html-node="true"><br data-preserve-html-node="true"> The disease generally presents itself in adults, with symptoms most commonly first presenting in their forties, is diagnosed through genetic testing, and is characterized by cognitive dysfunction, neuropsychiatric symptoms, and motor impairment. These symptoms typically exhibit rapid progression with a life expectancy of approximately six to seven years on average after diagnosis, causing significant patient and caregiver burden. There are currently no approved products for the treatment of ALSP, underlining the high unmet need in this rare indication.<br data-preserve-html-node="true"><br data-preserve-html-node="true"> <strong data-preserve-html-node="true" u="">Therapeutic Rationale for ALSP</strong><br data-preserve-html-node="true"><br data-preserve-html-node="true"> <span data-preserve-html-node="true" style="color:#737373">ALSP is caused by loss-of-function mutations in the <i data-preserve-html-node="true">CSF1R</i> gene, which lead to microglial dysfunction. Both TREM2 and CSF1R transduce their biological effects, including cell survival and proliferation signals, through the same signaling partner, DAP12/SYK. Iluzanebart is designed to increase signaling through DAP12/SYK to compensate for CSF1R loss-of-function by mitigating microglial dysfunction. Vigil has generated robust evidence that TREM2 agonism can rescue CSF1R loss of signaling in preclinical models. We believe iluzanebart represents a compelling therapeutic approach for ALSP through TREM2 agonism to compensate for CSF1R’s decreased signaling and correct microglia dysfunction.<br data-preserve-html-node="true"><br data-preserve-html-node="true"> <p></p> </span></span> </div></div><div class="sqs-block horizontalrule-block sqs-block-horizontalrule" data-block-type="47" id="block-a0912a0f148db522df77"><div class="sqs-block-content"><hr /></div></div><div class="sqs-block html-block sqs-block-html" data-block-type="2" id="block-yui_3_17_2_1_1736973412424_18183"><div class="sqs-block-content"> <div class="sqs-html-content"> <h3 style="white-space:pre-wrap;"><strong>VG-3927</strong> – an orally-available, small molecule TREM2 agonist</h3><p class="" style="white-space:pre-wrap;">VG-3927 is currently being evaluated in a Phase 1 clinical trial</p> </div> </div></div><div class="sqs-block markdown-block sqs-block-markdown" data-block-type="44" id="block-a13815226d739722867e"><div class="sqs-block-content"><p><span data-preserve-html-node="true" style="color:#FCB017"><strong data-preserve-html-node="true" p="">About Alzheimer’s disease (AD)</strong></span> <span data-preserve-html-node="true" style="color:#737373"></span></p> <p data-preserve-html-node="true"><span data-preserve-html-node="true" style="color:#737373">AD is the most common cause of dementia, a general term for the loss of memory and other cognitive abilities severe enough to interfere with daily life. AD accounts for 60-80% of dementia cases, and the majority of people with AD are aged 65 and older. A progressive disease, AD usually presents with mild memory loss and progresses to include disorientation, loss of initiative or judgment, difficulty with self-care, behavioral problems, and general mental decline. AD affects an estimated 6.2 million patients in the U.S. </span></p><p><strong data-preserve-html-node="true">Therapeutic Rationale for AD</strong><br data-preserve-html-node="true"><br data-preserve-html-node="true"> <span data-preserve-html-node="true" style="color:#737373">We believe that the next Alzheimer’s disease-modifying treatments will go beyond targeting single toxic species and boost the brain’s immune system to broadly and effectively counter multiple processes that contribute to AD. <br data-preserve-html-node="true"> Strong genetic and functional data have established a causal link between TREM2 and AD in humans. Genome wide association studies (GWAS) have shown that a specific mutation in a TREM2 variant (R47H) is one of the strongest genetic risk factors for AD, second in magnitude only to that associated with the apolipoprotein E4 (ApoE4) genotype. Beyond the evidence demonstrating that TREM2 mutations are associated with increased AD risk, recent studies further strengthen its role by showing that increased TREM2 expression is protective against AD. <br data-preserve-html-node="true"> TREM2 is the key receptor that senses the presence of multiple ligands that indicate trouble – including Aβ and ApoE. When these ligands are elevated, they bind to TREM2, triggering changes in microglia so they can remove the damage or pathologic aggregates and debris. By activating TREM2 with an agonist, we aim to enhance the natural neuroprotective function of microglia in AD, boosting their ability to neutralize multiple causes of AD pathology <br data-preserve-html-node="true"><br data-preserve-html-node="true"></span></p> </div></div><div class="sqs-block horizontalrule-block sqs-block-horizontalrule" data-block-type="47" id="block-c3b956337a0e4d674cd5"><div class="sqs-block-content"><hr /></div></div><div class="sqs-block html-block sqs-block-html" data-block-type="2" data-border-radii="{"topLeft":{"unit":"px","value":0.0},"topRight":{"unit":"px","value":0.0},"bottomLeft":{"unit":"px","value":0.0},"bottomRight":{"unit":"px","value":0.0}}" id="block-ec1ca7212310acdd4447"><div class="sqs-block-content"> <div class="sqs-html-content"> <h2 style="white-space:pre-wrap;"><strong>Novel Targets and New Indications</strong></h2><p class="" style="white-space:pre-wrap;">We plan to expand our pipeline through internal discovery and development as well as strategic collaborations or alliances with academic organizations or pharmaceutical or biotechnology companies.</p> </div> </div></div><div class="sqs-block horizontalrule-block sqs-block-horizontalrule" data-block-type="47" id="block-cd801af63fc496580d26"><div class="sqs-block-content"><hr /></div></div></div></div></div> </div> <figure class="Index-page-image" data-parallax-image-wrapper> <img data-src="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606101918158-V36QQAFN9IU5E01L8FIZ/white-background-lighter.jpg" data-image="https://images.squarespace-cdn.com/content/v1/5f77665fce2a6e2e65763cf0/1606101918158-V36QQAFN9IU5E01L8FIZ/white-background-lighter.jpg" data-image-dimensions="1920x1080" data-image-focal-point="0.5,0.5" alt="white-background-lighter.jpg" data-load="false" alt="" /> </figure> </section> <nav class="Index-nav"> <div class="Index-nav-inner"> <a href="#bannernew" class="Index-nav-item active"> <div class="Index-nav-indicator"></div> <div class="Index-nav-text"><span>BANNER</span></div> </a> <a href="#calloutnew" class="Index-nav-item"> <div class="Index-nav-indicator"></div> <div class="Index-nav-text"><span>CALLOUT</span></div> </a> <a href="#programsnew" class="Index-nav-item"> <div class="Index-nav-indicator"></div> <div class="Index-nav-text"><span>PROGRAMS</span></div> </a> </div> </nav> </main> </div> </div> <footer class="Footer" role="contentinfo" data-controller="FooterBreakpoints"> <div class="Footer-inner clear"> <div class="sqs-layout sqs-grid-12 columns-12 Footer-blocks Footer-blocks--top sqs-alternate-block-style-container" data-layout-label="Footer Top Blocks" data-type="block-field" data-updated-on="1706719283646" id="footerBlocksTop"><div class="row sqs-row"><div class="col sqs-col-5 span-5"><div class="sqs-block image-block sqs-block-image" data-block-type="5" id="block-yui_3_17_2_1_1605188195708_4052"><div class="sqs-block-content"> <div class=" image-block-outer-wrapper layout-caption-hidden design-layout-inline combination-animation-none individual-animation-none individual-text-animation-none " data-test="image-block-inline-outer-wrapper" > <figure class=" sqs-block-image-figure intrinsic " style="max-width:500px;" > <div class="image-block-wrapper" data-animation-role="image" > <div class="sqs-image-shape-container-element has-aspect-ratio " style=" position: relative; 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