R＆D - GC Cell

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url(/resources/assets/images/sub_visual_pipeline.jpg)"> <h2 class="top__title" data-aos="fade-up">Development Pipeline</h2> <div class="top__nav" id="nav" data-aos="fade-up" data-aos-delay="200"> <span>R&D</span> <span>Development Pipeline</span> </div> </div>  <div class="shapes-wrap"> <span class="shapes shapes--subkv"> <img src="/resources/assets/images/sub-kvimg_02.svg" alt="img" > </span> </div>  </section> <div class="content pipeline"> <article class="article" id="section01"> <div class="view-row"> <div class="sub-shapes"> <span class="shapes shapes--sub02"></span> </div> </div> <div class="site-row"> <div class="inbox"> <h3 class="st-01"> One More Step for Future<br class="md-d-none" > Cell and Gene Therapy R&D </h3> <div class="col-list"> <h4 class="italic">R&D Highlights</h4> <ul> <li><p>동종 CAR-NK 세포치료제 연구개발</p></li> <li><p>Onco-therapy 세포유전자치료 플랫폼 고도화</p></li> <li><p>First-in-class or Best-in-class 후보 물질 발굴</p></li> <li><p>면역항암치료 적응증 확대</p></li> </ul> </div> <div class="pipeline__table"> <table> <caption></caption> <colgroup> <col class="table-col--10" > <col class="table-col--12" > <col class="table-col--15" > <col class="table-col--14" > <col class="table-col--13" > <col class="table-col--13" > <col class="table-col--13" > <col class="table-col--08" > </colgroup> <thead> <tr> <th>Classification</th> <th>Project</th> <th>Research</th> <th>Preclinical</th> <th>Phase 1</th> <th>Phase 2</th> <th>Phase 3</th> <th>BLA</th> </tr> </thead> <tbody>  <tr> <th rowspan="2">Autologous</th> <td>GCC4002 <br>(Immuncell-LC, <br>CIK**)</td> <td class="tbl-graph tbl-graph--Autologous" colspan="6"> <div class="tbl-graph__wrap"> <div class="tbl-graph__bg"> <div class="tbl-graph__gauge" data-width="75" data-aos=""> <span class="tbl-graph--lefttext" data-aos="fade" data-aos-delay="1000">Pancreatic Cancer</span> </div> <span class="tbl-graph--bgtext" data-aos="fade" data-aos-delay="1000">Ph3 on-going</span> </div> </div> </td> </tr> <tr> <td>GCC4002 <br>(Immuncell-LC, <br>CIK**)</td> <td class="tbl-graph tbl-graph--Autologous" colspan="6"> <div class="tbl-graph__wrap"> <div class="tbl-graph__bg"> <div class="tbl-graph__gauge" data-width="100" data-aos=""> <span class="tbl-graph--lefttext" data-aos="fade" data-aos-delay="1000">Liver cancer(HCC)</span> <span class="tbl-graph--righttext" data-aos="fade" data-aos-delay="1000">Approved in Korea</span> </div> </div> </div> </td> </tr>   <tr class="tbl-stadard" > <th rowspan="6">Allogeneic</th> <td>GCC4001 <br>(AB-101, <br>Naive NK Cell) <br>+ Rituximab</td> <td class="tbl-graph tbl-graph--Allogeneic" colspan="6"> <div class="tbl-graph__wrap"> <div class="tbl-graph__bg"> <div class="tbl-graph__gauge" data-width="42" data-aos=""> <span class="tbl-graph--lefttext" data-aos="fade" data-aos-delay="1000">r/r* Lymphoma</span> </div> <span class="tbl-graph--bgtext" data-aos="fade" data-aos-delay="1000">Ph1 on-going</span> </div> </div> </td> <tr > <td>GCC4001 <br>(AB-101, <br>Naive NK Cell) <br>+ Rituximab</td> <td class="tbl-graph tbl-graph--Allogeneic" colspan="6"> <div class="tbl-graph__wrap"> <div class="tbl-graph__bg"> <div class="tbl-graph__gauge" data-width="41" data-aos=""> <span class="tbl-graph--lefttext" data-aos="fade" data-aos-delay="1000">Lupus (Autoimmune)</span> </div> <span class="tbl-graph--bgtext" data-aos="fade" data-aos-delay="1000">IND cleared by US FDA </span> </div> </div> </td> <tr > <td>GCC4001 <br>(AB-101, <br>Naive NK Cell) <br>+ AFM13</td> <td class="tbl-graph tbl-graph--Allogeneic" colspan="6"> <div class="tbl-graph__wrap"> <div class="tbl-graph__bg"> <div class="tbl-graph__gauge" data-width="55" data-aos=""> <span class="tbl-graph--lefttext" data-aos="fade" data-aos-delay="1000">r/r* Hodgkin Lymphoma / CD30+ Peripheral T-Cell Lymphoma</span> </div> <span class="tbl-graph--bgtext" data-aos="fade" data-aos-delay="1000">Ph2 cleared by US FDA </span> </div> </div> </td> <tr > <td>GCC2003 <br>(AB-201, <br>HER2 CAR-NK)</td> <td class="tbl-graph tbl-graph--Allogeneic" colspan="6"> <div class="tbl-graph__wrap"> <div class="tbl-graph__bg"> <div class="tbl-graph__gauge" data-width="33" data-aos=""> <span class="tbl-graph--lefttext" data-aos="fade" data-aos-delay="1000">HER2+ Solid Cancer</span> </div> <span class="tbl-graph--bgtext" data-aos="fade" data-aos-delay="1000">Multi-regional study; IND cleared by US FDA; IND cleared in Australia and Korea</span> </div> </div> </td> <tr > <td>GCC2004 <br>(AB-202, <br>CD19 CAR-NK)</td> <td class="tbl-graph tbl-graph--Allogeneic" colspan="6"> <div class="tbl-graph__wrap"> <div class="tbl-graph__bg"> <div class="tbl-graph__gauge" data-width="24" data-aos=""> <span class="tbl-graph--lefttext" data-aos="fade" data-aos-delay="1000">B-cell Lymphoma</span> </div> </div> </div> </td> <tr > <td>GCC2005 <br>(AB-205, <br>CD5 CAR-NK)</td> <td class="tbl-graph tbl-graph--Allogeneic" colspan="6"> <div class="tbl-graph__wrap"> <div class="tbl-graph__bg"> <div class="tbl-graph__gauge" data-width="41" data-aos=""> <span class="tbl-graph--lefttext" data-aos="fade" data-aos-delay="1000">T-cell Lymphoma</span> </div> <span class="tbl-graph--bgtext" data-aos="fade" data-aos-delay="1000">IND cleared by MFDS</span> </div> </div> </td>  </tbody> </table> <div class="pipeline__tablebottomtext"> * r/r : Relapsed/Refractory<br> ** CIK, cytokine-induced killer cell </div> </div> </div> </div> </article> <article class="article" id="section02"> <div class="site-row"> <div class="inbox"> <h4>GC Cell NK Competitiveness</h4> </div> <div class="pipeline__global"> <div class="inbox"> <div class="bg-shape"> <div class="bg-shape__el wiper-box" data-aos="slide-left"></div> </div> <div class="inbox__wiper inbox__wiper--pipeline"> <div class="area"> <div class="pipeline__figure" data-aos="fade" data-aos-delay="500"> <img src="/resources/assets/images/pipeline_img01.jpg" alt="img" > </div> <div class="pipeline__content"> <ul> <li data-aos="fade-up"> <div class="inbox__icon"> <img src="/resources/assets/images/pipeline_icon01.svg" alt="img" > </div> <div> <p class="pipeline__top">Efficacy</p> <div class="pipeline__bottom"> <p>항암 활성화가 유지된 세포치료제</p> </div> </div> </li> <li data-aos="fade-up"> <div class="inbox__icon"> <img src="/resources/assets/images/pipeline_icon02.svg" alt="img" > </div> <div> <p class="pipeline__top">Accessibility</p> <div class="pipeline__bottom"> <p>냉동보존 상태 유지를 통해 투여가 필요한 환자에게 시간 지연이 없는 요법</p> </div> </div> </li> <li data-aos="fade-up"> <div class="inbox__icon"> <img src="/resources/assets/images/pipeline_icon03.svg" alt="img" > </div> <div> <p class="pipeline__top">Affordable</p> <div class="pipeline__bottom"> <p>대량 생산이 가능한 공정개발로 치료제 비용 절감</p> </div> </div> </li> <li data-aos="fade-up"> <div class="inbox__icon"> <img src="/resources/assets/images/pipeline_icon04.svg" alt="img" > </div> <div> <p class="pipeline__top">Safety</p> <div class="pipeline__bottom"> <p>입원과 지속적인 모니터링이 필요한 CAR-T 또는 T 세포 인게이저 치료 요법과 달리 외래 치료 형태로 관리 가능</p> </div> </div> </li> <li data-aos="fade-up"> <div class="inbox__icon"> <img src="/resources/assets/images/pipeline_icon05.svg" alt="img" > </div> <div> <p class="pipeline__top">Flexible treatment for each individual patient</p> <div class="pipeline__bottom"> <p class="b_dash">단일클론 항체 또는 인게이저 병용을 통한 다중 표적 접근법</p> <p class="b_dash">치료 기간 중 반복 투여 가능</p> </div> </div> </li> </ul> </div> </div> </div> </div> </div> </div> </article> <article class="article" id="section03"> <div class="sub-shapes pcv"> <span class="shapes shapes--pipeline01"></span> </div> <div class="site-row"> <div class="inbox"> <h4>CBNK (Cord blood-derived NK)</h4> <div class="pipeline__dsecription"> <p> GC Cell CBNK(AB101)는 독자적인 지지 세포(feeder cell) 시스템을 기반으로 개발된 비조작, 냉동보존<sup>[1]</sup> 동종이계 기성품 형태 NK 세포치료제입니다. eHut78 조작 지지 세포(engineered feeder cell)를 활용한 세포 대량 배양 및 제조 플랫폼은 최적의 NK 세포 대량 배양과 강력한 항암 활성을 가능하게 하게 합니다.<sup>[2]</sup> 당사의 첨단 기술은 환자 1명의 제대혈에서 최대 5,000 dose의 AB-101 대량 생산과 NK 세포의 우수한 품질 관리를 가능하게 합니다. </p> </div> <div class="pipeline__cbnk"> <ul class="cbnk"> <li data-aos="fade-right"> <div class="cbnk__box"> <span class="cbnk__order">01</span> <h5 class="cbnk__name">Isolation</h5> <p class="cbnk__text">CD3 Depletion</p> <div class="cbnk__figure"> <img src="/resources/assets/images/pipeline_cbnk01.jpg" alt="img" > <p class="cbnk__figuretext">Immature Cord Blood <br>NK Cells</p> </div> </div> </li> <li data-aos="fade-right" data-aos-delay="100"> <div class="cbnk__box"> <span class="cbnk__order">02</span> <h5 class="cbnk__name">Activation & Expansion #1</h5> <p class="cbnk__text">Bag Culture</p> <div class="cbnk__figure"> <img src="/resources/assets/images/pipeline_cbnk02.jpg" alt="img" > </div> </div> </li> <li data-aos="fade-right" data-aos-delay="200"> <div class="cbnk__box"> <span class="cbnk__order">03</span> <h5 class="cbnk__name">Master Cell Bank</h5> <p class="cbnk__text"> Cryostorage<br> ±80 bags @ 10<sup class="black">8</sup> cells/bag </p> <div class="cbnk__figure"> <img src="/resources/assets/images/pipeline_cbnk03.jpg" alt="img" class="pipeline-pcv" > <img src="/resources/assets/images/pipeline_cbnk03_mo.png" alt="img" class="pipeline-mov" > <img src="/resources/assets/images/pipeline_cbnk03_arrow.png" alt="img" class="cbnk--arrow" > </div> </div> </li> <li data-aos="fade-right" data-aos-delay="300"> <div class="cbnk__box"> <span class="cbnk__order">04</span> <h5 class="cbnk__name">Activation & Expansion #2</h5> <p class="cbnk__text">50L Bioreactor</p> <div class="cbnk__figure"> <img src="/resources/assets/images/pipeline_cbnk04.jpg" alt="img" > </div> </div> </li> <li data-aos="fade-right" data-aos-delay="400"> <div class="cbnk__box"> <span class="cbnk__order">05</span> <h5 class="cbnk__name">Drug Product</h5> <p class="cbnk__text"> Cryostorage<br> 5,000’s of Doses/Cord </p> <div class="cbnk__figure"> <img src="/resources/assets/images/pipeline_cbnk05.jpg" alt="img" > </div> </div> </li> </ul> </div> <div class="pipeline__engineer"> <div class="pipeline__engineerwrp"> <div class="pipeline__engineerimage"> <button type="button" class="enlarge-layer-open"> <img src="/resources/assets/images/pipeline_img03.svg" alt="img" > </button> </div> <div class="pipeline__engineertext"> <div class="pipeline__engineertitle">Gene Engineered-CBNK</div> <p class="pipeline__engineersub"> 키메라 항원 수용체(CAR)를 발현하는 GC Cell의 동종유래 유전자 조작 NK 세포치료제는 혈액암과 고형암에서 향상된 표적화 치료 요법을 보여줍니다. 당사의 독자적인 CAR 플랫폼은 CD28 및 OX40L 보조자극 분자를 활용하여 활성화 신호를 증폭하고, IL-15 사이토카인을 분비하여 NK 세포 지속성을 증가시킴으로써<sup>[3~4]</sup> 치료 효과를 극대화한 플랫폼 기술입니다. </p> </div> </div> <div class="pipeline__engineerbottom"> <ul> <li><sup>[1]</sup>세포의 동결보존용 배지 조성물 및 이의 용도 (PCT/KR2017/000859)</li> <li><sup>[2]</sup>형질전환된 T세포를 이용한 제대혈 유래 자연살해세포의 배양방법 (PCT/KR2019/015469)</li> <li><sup>[3]</sup>키메라 항원 수용체 및 이를 발현하는 자연살해세포 (PCT/KR2017/015635)</li> <li><sup>[4]</sup>키메라 항원 수용체 및 IL-15를 포함하는 융합단백질 (PCT/KR2022/095077)</li> </ul> </div> </div> </div> </div> </article> </div> </div>  <footer id="footer" 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