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'' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); 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document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. 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Professor of Biomedical Engineering, Ulsan National Institute of Science and Technology; Genome Lab and Korean Genomics Center</b></p> <p> </p> <p>Expanding genetic disease testing in Korea with customizable population genomics microarrays</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-46dc71e442"> <a class="cmp-ctaitem__anchor" href="https://assets.thermofisher.com/TFS-Assets/GSD/Reference-Materials/clinomics-scientist-spotlight.pdf" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-bd39d3fdc7" class="cmp-container"> <div class="cmp-p-text"> <div id="text-703372591" class="cmp-text"> <p><strong>Dushyant Singh Baghel, MD, CEO of Nucleome Informatics</strong></p> <p> </p> <p>Investigating inherited retinal disease in India using customized genotyping arrays</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-d837b91695"> <a class="cmp-ctaitem__anchor" href="https://assets.thermofisher.com/TFS-Assets/LSG/Reference-Materials/dushyant-singh-baghel-spotlight.pdf" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-7290291a40" class="cmp-container"> <div class="cmp-p-text"> <div id="text-121380561" class="cmp-text"> <p><strong>Tuan Cao, Co-founder and CEO Genetica</strong></p> <p> </p> <p>Decoding unique Asian lifestyle and disease variants through collaboration and custom genotyping arrays</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-79faa93809"> <a class="cmp-ctaitem__anchor" href="http://assets.thermofisher.com/TFS-Assets/GSD/brochures/axiom_cytox_spotlight.pdf" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-5000a26333" class="cmp-container"> <div class="cmp-p-text"> <div id="text-505995985" class="cmp-text"> <p><strong>Richard Pither, PhD, CEO of Cytox</strong></p> <p> </p> <p>Transforming Alzheimer’s disease characterization through genetic risk scoring</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-e3b645e0a1"> <a class="cmp-ctaitem__anchor" href="http://assets.thermofisher.com/TFS-Assets/GSD/brochures/axiom_cytox_spotlight.pdf" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-fbdaf604bc" class="cmp-container"> <div class="cmp-p-text"> <div id="text-183088474" class="cmp-text"> <p><strong>Alexandre Pereira, MD, PhD, São Paulo University Heart Institute; 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Learn how polygenic risk scores enable early identification of individuals at higher lifetime risk of disease, to target screening or interventions. See Sir Professor Peter Donnelly's full presentation video on a vision for polygenic risk scores in health care</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-3bef179d30"> <a class="cmp-ctaitem__anchor" href="/sg/en/home/global/forms/life-science/predictive-genomics.html" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-820f0673a5" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1655364132" class="cmp-text"> <p><strong>The FinnGen Research Project: Combining Genomics and Health Record Data to Understand Disease Mechanisms</strong></p> <p> </p> <p>Hear Dr. Palotie speak about the research goal to improve our understanding of disease mechanisms, specifically in chronic diseases that affect a large part of the population, because that’s the clue toward new therapies; we need to understand more about the disease. And how we do that is we use special populations like the Finnish population, which has a special population history, providing certain benefits. </p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-4f9cca7846"> <a class="cmp-ctaitem__anchor" href="/blog/behindthebench/the-finngen-research-project-combining-genomics-and-health-record-data-to-understand-disease-mechanisms" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-2dd9e8053a" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1013946907" class="cmp-text"> <p><strong>Bringing predictive genomics into a nationwide model: A spotlight on the Taiwan Precision Medicine Initiative</strong></p> <p> </p> <p>Dr. Kwok has been at the forefront of large-scale genomic studies. One of his most well-known undertakings was a collaboration between Kaiser Permanente and UCSF where scientists genotyped more than 100,000 Kaiser Permanente members. Today he is focused on two far-reaching goals. First, how to make precision medicine more precise by increasing the diversity of genomic databases. Second, how to sensibly incorporate genetic information into regular clinical practice. </p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-d32a2255c2"> <a class="cmp-ctaitem__anchor" href="/blog/behindthebench/predictive-genomics-in-action-a-spotlight-on-dr-pui-yan-kwok-and-the-taiwan-precision-medicine-initiative/" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-c471e414e4"> <a class="cmp-ctaitem__anchor" href="https://assets.thermofisher.com/TFS-Assets/GSD/Reference-Materials/pui-yan-kwok-customer-profile.pdf" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">View pdf</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-026ff3a047" class="cmp-container"> <div class="cmp-p-text"> <div id="text-618359" class="cmp-text"> <p><strong>Integrating preemptive pharmacogenomics into health care.</strong></p> <p> </p> <p>Learn what Dr. Philip Empey, the Associate Director for Pharmacogenomics of the Pitt/UPMC Institute of Precision Medicine and Director of the University of Pittsburgh/Thermo Fisher Scientific Pharmacogenomics Center of Excellence has to say regarding the challenges to incorporate pharmacogenomics into routine clinical decision making.</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-abe43e41c0"> <a class="cmp-ctaitem__anchor" href="/blog/behindthebench/integrating-preemptive-pharmacogenomics-testing-into-routine-clinical-care-an-interview-with-dr-philip-empey/" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-fbe3bc55ea"> <a class="cmp-ctaitem__anchor" href="https://assets.thermofisher.com/TFS-Assets/GSD/Reference-Materials/philip-empey-customer-profile.pdf" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">View pdf</span> </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="cmp-accordion__item" data-cmp-hook-accordion="item" id="accordion-547aae55d1-item-b1cbb9ead3"> <h2 class="cmp-accordion__header"> <button id="accordion-547aae55d1-item-b1cbb9ead3-button" class="cmp-accordion__button" aria-controls="accordion-547aae55d1-item-b1cbb9ead3-panel" data-cmp-hook-accordion="button"> <span class="cmp-accordion__title">Webinars</span> <span class="cmp-accordion__icon"></span> </button> </h2> <div data-cmp-hook-accordion="panel" id="accordion-547aae55d1-item-b1cbb9ead3-panel" class="cmp-accordion__panel cmp-accordion__panel--hidden" role="region" aria-labelledby="accordion-547aae55d1-item-b1cbb9ead3-button"><div class="cmp-p-container"> <div id="container-b1cbb9ead3" class="cmp-container"> <div class="cmp-p-container p-l1"> <div id="container-d90a78319d" class="cmp-container"> <div class="cmp-p-text"> <div id="text-492076464" class="cmp-text"> <p><strong>Genotyping Techniques Used by Researchers</strong></p> <p> </p> <p>Webinar 1: Animal Genotyping - In the first part of this webinar, Dr. Sarwar Azam of National Institute of Animal Biotechnology, India, talks about cattle genotyping and in the second part of the webinar Dr. Srinivas Chandram, of Thermo Fisher Scientific, explains companion animal genotyping.</p> <p> </p> <p>Webinar 2: Plant Genotyping by Dr. Grant Poole presenting the basis for development of SNP‑based custom‑made and catalog arrays for wheat and rice.</p> <p> </p> <p>Webinar 3: Exploring Microarray Technology in Predictive Genomics by Dr. Liuh Ling Goh of TTSH Molecular Diagnostic Laboratory, Singapore</p> <p> </p> <p>Webinar 4: Enabling Better Health Outcomes through Predictive Genomics by Dr. Julian Wong, Sr. Product Manager, Thermo Fisher Scientific</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-5e0b748f94"> <a class="cmp-ctaitem__anchor" href="/sg/en/home/life-science/genotyping-techniques-webinar-series.html"> <span class="cmp-ctaitem__icon icon-24-playButton-mono"></span> <span class="cmp-ctaitem__text">View webinar series</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-ffb529908a" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1058563321" class="cmp-text"> <p><strong>Qatar Genome Program: Building the next generation of infrastructures to test the value of predictive genomics</strong></p> <p>Qatar Precision Medicine Institute/Qatar Genome Program is building the next generation of infrastructures to test the value of predictive genomics</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-6b458533ff"> <a class="cmp-ctaitem__anchor" href="/sg/en/home/global/forms/life-science/infrastructure-predictive-genomics-webinar.html"> <span class="cmp-ctaitem__icon icon-24-playButton-mono"></span> <span class="cmp-ctaitem__text">View webinar</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-73fa552243" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1662678030" class="cmp-text"> <p><b>The future of predictive genomics in Israel</b></p> <p> </p> <p>What will it take to enable the implementation of predictive genomics in Israel's healthcare system? What are the challenges and how could these obstacles become opportunities?</p> <p>This innovative and educational webinar brings together global predictive genomics experts who share their perspectives on the present and future of predictive genomics in Israel</p> <p> </p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-1fb4ac9886"> <a class="cmp-ctaitem__anchor" href="https://players.brightcove.net/3663210762001/default_default/index.html?videoId=6322263000112" target="_blank"> <span class="cmp-ctaitem__icon icon-24-playButton-mono"></span> <span class="cmp-ctaitem__text">View webinar </span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-44950e7d70" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1630501616" class="cmp-text"> <p><strong>Predictive genomics webinar series</strong></p> <p> </p> <p>Listen from global experts how genomics innovations are changing future of healthcare</p> <p><br /> Webinar 1: Genomics enabling population and personalized health by Aarno Palotie, MD, PhD and Importance of population-based biobanks in predictive genomics and personalized medicine-Vision of the future by Andres Metspalu</p> <p> </p> <p>Webinar 2: What it takes to build a predictive genomics program by Samuli Ripatti</p> <p> </p> <p>Webinar 3: Massively parallel genetic testing of the Han Chinese population in Taiwan: Lessons from the east by Pui-Yan Kwok, MD, PhD</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-edfd3e6449"> <a class="cmp-ctaitem__anchor" href="/sg/en/home/global/forms/life-science/predictive-genomics-insights.html"> <span class="cmp-ctaitem__icon icon-24-playButton-mono"></span> <span class="cmp-ctaitem__text">View webinar series</span> </a> </div> </div> </div> </div> <div class="cmp-p-container m--match-height"> <div id="container-d92b0042fc" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-p-container p-l1 aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div id="container-9f716448df" class="cmp-container"> <div class="aem-Grid aem-Grid--default--6 "> <div class="cmp-p-textimage m--title-over-img aem-GridColumn aem-GridColumn--default--6"><div class="cmp-textimage cta-container" id="textimage-143152" data-cmp-hook-cta="ctapanel"> <div class="cmp-textoverlay"> <div class="cmp-textoverlay__gradient cmp-textoverlay__gradient_black"></div> <div class="cmp-textoverlay__textwrapper"> <h2 class="cmp-textoverlay__title">On-demand webinar</h2> <h4 class="cmp-textoverlay__subtitle"> Importance of imputation accuracy in the selection of human genotyping arrays </h4> <p>Dr. Nam of GeneStory, Vietnam, explains imputation's impact on genotyping array accuracy, factors for selecting a suitable array, and a country's experience analyzing PRS in under-represented populations.</p> </div> <div class="cmp-ctalist"> <div class="cmp-p-ctaitem"><div class="cmp-ctaitem" id="ctaitem-105eb99b77"> <a class="cmp-ctaitem__anchor" href="/sg/en/home/global/forms/life-science/imputation-accuracy-genotyping-webinar.html"> <span class="cmp-ctaitem__text">Watch webinar</span> </a> </div> </div> </div> </div> <div data-cmp-is="image" data-cmp-src="/content/dam/tfsite/images/storefront/microarrays-genomics/Dr.Nam1920x688.png" data-asset="/content/dam/tfsite/images/storefront/microarrays-genomics/Dr.Nam1920x688.png" id="textimage-143152" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject"> <noscript data-cmp-hook-image="noscript"> <img src="/content/dam/tfsite/images/storefront/microarrays-genomics/Dr.Nam1920x688.png" class="cmp-image__image" loading="lazy" itemprop="contentUrl" data-cmp-hook-image="image" alt/> </noscript> </div>  </div> </div> </div> </div> </div> <div class="cmp-p-container p-l1 aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div id="container-fa95cd4b27" class="cmp-container"> <div class="aem-Grid aem-Grid--default--6 "> <div class="cmp-p-textimage m--title-over-img aem-GridColumn aem-GridColumn--default--6"><div class="cmp-textimage cta-container" id="textimage-1513774656" data-cmp-hook-cta="ctapanel"> <div class="cmp-textoverlay"> <div class="cmp-textoverlay__gradient cmp-textoverlay__gradient_black"></div> <div class="cmp-textoverlay__textwrapper"> <h2 class="cmp-textoverlay__title">On-demand webinar</h2> <p>Dr. Steven Melnick and Dr. David B. 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The tutorial explain what Predictive Genomics, Population Genomics, Pharmacogenomics and how Microarrays are used in these application areas.</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-8d0d769484"> <a class="cmp-ctaitem__anchor" href="https://players.brightcove.net/3663210762001/default_default/index.html?videoId=6324363396112" target="_blank"> <span class="cmp-ctaitem__icon icon-16-play-bold"></span> <span class="cmp-ctaitem__text">Watch video</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-574aa66b11" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1183390871" class="cmp-text"> <p>Thermo Fisher Scientific Microarray Technology</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-ad8399314e"> <a class="cmp-ctaitem__anchor" href="https://players.brightcove.net/3663210762001/default_default/index.html?videoId=6323617991112" target="_blank"> <span class="cmp-ctaitem__icon icon-16-play-bold"></span> <span class="cmp-ctaitem__text">Watch video</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-7227bd8acd" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1705930549" class="cmp-text"> <p>The vision of Pharmacogenomics</p> <p> </p> <p>The estimated annual cost of drug-related morbidity and mortality resulting from non-optimized medication therapy was $528.4 billion in the United States alone in 2016, equivalent to 16 percent of the country’s total health care expenditures. Pharmacogenomics, the understanding of how genes impact an individual’s response to medications, promises to change that. Significant progress has been made in using genomics to determine the safest, most effective course of treatments for individuals and, as these programs scale and go mainstream, we have reached a tipping point where they are starting to deliver on their promise of improving the health of communities and significantly lowering healthcare costs. </p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-f1730e67f9"> <a class="cmp-ctaitem__anchor" href="/sg/en/home/clinical/precision-medicine/precision-medicine-learning-center/precision-medicine-resource-library/precision-medicine-articles/pharmacogenomics-ready-mainstream.html"> <span class="cmp-ctaitem__icon icon-16-play-bold"></span> <span class="cmp-ctaitem__text">Watch video</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-03ccdd7d04" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1368548073" class="cmp-text"> <p>Predictive Genomics and Microarray Tutorial Video</p> <p> </p> <p>Learn about Predictive Genomics. The tutorial explain what Predictive Genomics, Population Genomics, Pharmacogenomics and how Microarrays are used in these application areas.</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-af849d4860"> <a class="cmp-ctaitem__anchor" href="https://players.brightcove.net/3663210762001/default_default/index.html?videoId=6324363396112" target="_blank"> <span class="cmp-ctaitem__icon icon-16-play-bold"></span> <span class="cmp-ctaitem__text">Watch video</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-aa9a86a4fd" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1687873036" class="cmp-text"> <p>Customer & Expert Testimonial Videos</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-a4c6ececb4"> <a class="cmp-ctaitem__anchor" href="/sg/en/home/brands/applied-biosystems/population-genomics.html"> <span class="cmp-ctaitem__icon icon-16-play-bold"></span> <span class="cmp-ctaitem__text">Watch video</span> </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="cmp-accordion__item" data-cmp-hook-accordion="item" id="accordion-547aae55d1-item-e8cf12f80e"> <h2 class="cmp-accordion__header"> <button id="accordion-547aae55d1-item-e8cf12f80e-button" class="cmp-accordion__button" aria-controls="accordion-547aae55d1-item-e8cf12f80e-panel" data-cmp-hook-accordion="button"> <span class="cmp-accordion__title">Blog posts</span> <span class="cmp-accordion__icon"></span> </button> </h2> <div data-cmp-hook-accordion="panel" id="accordion-547aae55d1-item-e8cf12f80e-panel" class="cmp-accordion__panel cmp-accordion__panel--hidden" role="region" aria-labelledby="accordion-547aae55d1-item-e8cf12f80e-button"><div class="cmp-p-container"> <div id="container-e8cf12f80e" class="cmp-container"> <div class="cmp-p-container p-l1"> <div id="container-f017e99cba" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1415165267" class="cmp-text"> <p>What Should Be Reported to Participants in a Genomics Screening Program?</p> <p> </p> <p>Several different types of information could be reported to participants in genomics-based screening programs. Rare inherited diseases might affect the participant themselves (autosomal dominant) or might not affect the participant but could affect their offspring (autosomal recessive). The risk for common complex diseases, such as diabetes or heart disease, may be assessed by polygenic risk scores that combine the effects of multiple low-impact variants. Pharmacogenetics captures variation in the way humans process drugs. Traits and ancestry do not have direct medical implications. Each of these categories has pros and cons when considering their inclusion in a genomics-based screening program. Genomics-based screening is not currently recommended for routine clinical use, but results may be returned to participants as part of an IRB-approved research study.</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-00fb000dbf"> <a class="cmp-ctaitem__anchor" href="/blog/behindthebench/what-should-health-systems-report-to-participants-in-genomics-screening-programs/" target="_blank"> <span class="cmp-ctaitem__icon icon-24-externalLink-bold"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-c4c2f11478" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1341066639" class="cmp-text"> <p>How Health Systems and National Initiatives Benefit from Genotype-Phenotype Research Databases</p> <p> </p> <p>Building a monetizable data asset is the most common rationale for investing in a large genotype-phenotype database, but there are several other compelling reasons to move forward, including better risk segmentation and targeting interventions, participant engagement and activation, participant recruitment/retention, “marketing sizzle,” the perception of innovation, and the recruitment/retention of high-quality physician-researchers.</p> <p> </p> <p>Investing in a large genotype-phenotype research database creates a monetizable data asset, particularly for pharmaceutical companies. The basic hypothesis is that genetics can help drug-makers identify and accelerate the development of relevant molecules that reach the right disease targets, while avoiding investments in programs based on less well-validated targets.</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-188a7eab87"> <a class="cmp-ctaitem__anchor" href="/blog/behindthebench/how-health-systems-and-national-initiatives-benefit-from-genotype-phenotype-research-databases/" target="_blank"> <span class="cmp-ctaitem__icon icon-24-externalLink-bold"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-7d838a313b" class="cmp-container"> <div class="cmp-p-text"> <div id="text-632063277" class="cmp-text"> <p>The Impact of Genetic Diversity on the Future of Health and Medicine</p> <p> </p> <p>Personalizing health by tailoring treatments and predicting disease risk is predicated on understanding individual variation related to disease, behavioral and environmental factors. Global initiatives have taken aim at collecting comprehensive genetic, biologic and clinical data. Unfortunately, the majority of these initiatives primarily include people of European descent, creating inequities in non-European populations. If health systems, governments and academic research institutes want to better serve their communities, citizens and research efforts, population-based biobanks need to be representative of people with different genetic backgrounds, including marginalized and hard-to-reach groups. Failure to do this will lead to further inequities in health care.</p> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-46fc90f844"> <a class="cmp-ctaitem__anchor" href="/blog/behindthebench/the-impact-of-genetic-diversity-on-the-future-of-health-and-medicine/" target="_blank"> <span class="cmp-ctaitem__icon icon-24-externalLink-bold"></span> <span class="cmp-ctaitem__text">Learn more</span> </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="cmp-accordion__item" data-cmp-hook-accordion="item" id="accordion-547aae55d1-item-cadc634d81"> <h2 class="cmp-accordion__header"> <button id="accordion-547aae55d1-item-cadc634d81-button" class="cmp-accordion__button" aria-controls="accordion-547aae55d1-item-cadc634d81-panel" data-cmp-hook-accordion="button"> <span class="cmp-accordion__title">Publications and posters</span> <span class="cmp-accordion__icon"></span> </button> </h2> <div data-cmp-hook-accordion="panel" id="accordion-547aae55d1-item-cadc634d81-panel" class="cmp-accordion__panel cmp-accordion__panel--hidden" role="region" aria-labelledby="accordion-547aae55d1-item-cadc634d81-button"><div class="cmp-p-container"> <div id="container-cadc634d81" class="cmp-container"> <div class="cmp-p-container p-l1"> <div id="container-2a07b04760" class="cmp-container"> <div class="cmp-p-text"> <div id="text-1406770113" class="cmp-text"> <p>The selection of publications and posters below focuses on large-scale predictive genomic studies citing the use of the <a href="/sg/en/home/life-science/microarray-analysis/human-genotyping-pharmacogenomic-microbiome-solutions-microarrays.html">Axiom whole-genome microarray platform</a>.</p> </div> </div> </div> </div> <div class="cmp-p-container p-l1"> <div id="container-768f9e5e87" class="cmp-container"> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-577366137b"> <a class="cmp-ctaitem__anchor" href="https://assets.thermofisher.com/TFS-Assets/GSD/Reference-Materials/pg-compendium.pdf" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Predictive Genomics Publication compendium</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-d6a67eb35f"> <a class="cmp-ctaitem__anchor" href="https://www.medrxiv.org/content/10.1101/2020.05.01.20088054v1" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">The landscape of host genetic factors involved in infection to common viruses and SARS-CoV-2 May 2020</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-75ce6a5af7"> <a class="cmp-ctaitem__anchor" href="https://www.medrxiv.org/content/10.1101/2020.04.19.20071936v1" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank April 2020</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-c5f361dcb1"> <a class="cmp-ctaitem__anchor" href="https://www.biorxiv.org/content/10.1101/702910v1" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa July 2019</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-1414a64fb4"> <a class="cmp-ctaitem__anchor" href="https://www.nature.com/articles/s41586-018-0579-z" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">The UK Biobank resource with deep phenotyping and genomic data Oct 2018</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-1c7e2ff5ba"> <a class="cmp-ctaitem__anchor" href="https://www.nature.com/articles/s41408-018-0132-1" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Differences in genomic abnormalities among African individuals with monoclonal gammopathies using calculated ancestry</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-a546af7796"> <a class="cmp-ctaitem__anchor" href="https://www.nature.com/articles/s41598-018-37832-9" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits Feb 2019</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-eefc512bb2"> <a class="cmp-ctaitem__anchor" href="https://pubmed.ncbi.nlm.nih.gov/27025970/" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Identification of PTCSC3 as a Novel Locus for Large-Vessel Ischemic Stroke: A Genome-Wide Association Study</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-963e56e037"> <a class="cmp-ctaitem__anchor" href="https://www.nature.com/articles/s41588-018-0183-z" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-2831d69ff3"> <a class="cmp-ctaitem__anchor" href="https://www.ncbi.nlm.nih.gov/pubmed/30554720" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-e876ac3715"> <a class="cmp-ctaitem__anchor" href="https://pdfs.semanticscholar.org/eca2/c984e560509fa554ba34049aa424a944f53d.pdf?_ga=2.15430069.2053716924.1553236416-1063674356.1553236416%20Pharmacogenetic%20content%20of%20commercial%20genome-wide%20genotyping%20arrays" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">The Diversity of REcent and Ancient huMan (DREAM): A New Microarray for Genetic Anthropology and Genealogy, Forensics, and Personalized Medicine, Nov 2017</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-17a5773987"> <a class="cmp-ctaitem__anchor" href="https://www.futuremedicine.com/doi/10.2217/pgs-2017-0129" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Pharmacogenetic content of commercial genome-wide genotyping arrays</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-1d880ad121"> <a class="cmp-ctaitem__anchor" href="https://onlinelibrary.wiley.com/doi/full/10.1111/trf.15012" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Development and evaluation of a transfusion medicine genome wide genotyping array</span> </a> </div> </div> <div class="cmp-p-ctaitem m--btn-link"><div class="cmp-ctaitem" id="ctaitem-3cab1aeb73"> <a class="cmp-ctaitem__anchor" href="https://www.sciencedirect.com/science/article/pii/S0895435615004448" target="_blank"> <span class="cmp-ctaitem__icon icon-24-document-mono"></span> <span class="cmp-ctaitem__text">Million Veteran Program: A mega-biobank to study genetic influences on health and disease</span> </a> 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