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Modeling of the Cellular Uptake of Rigid Nanoparticles: Investigating the Influence of the Adaptation of the Cell鈥檚 Mechanical Properties during Endocytosis
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<div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 87351</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Modeling of the Cellular Uptake of Rigid Nanoparticles: Investigating the Influence of the Adaptation of the Cell鈥檚 Mechanical Properties during Endocytosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sarah%20Iaquinta">Sarah Iaquinta</a>, <a href="https://publications.waset.org/abstracts/search?q=Christophe%20Blanquart"> Christophe Blanquart</a>, <a href="https://publications.waset.org/abstracts/search?q=Elena%20Ishow"> Elena Ishow</a>, <a href="https://publications.waset.org/abstracts/search?q=Sylvain%20%20Freour"> Sylvain Freour</a>, <a href="https://publications.waset.org/abstracts/search?q=Frederic%20Jacquemin"> Frederic Jacquemin</a>, <a href="https://publications.waset.org/abstracts/search?q=Shahram%20Khazaie"> Shahram Khazaie</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticles have recently emerged as a possible cancer treatment tool. Several formulations have been used to enhance the uptake of these nanoparticles by cancer cells and avoid their immediate clearance when administrated in vivo. Most of the previous studies focus on the investigation of the influence of the mechanical properties of the cell membrane and the particle. However, these studies do not account for the variation of adhesion and tension during the wrapping of the nanoparticle by the membrane. These couplings should be considered since the cell adapts to the interaction with the nanoparticle by, e.g., increasing the number of interactions (consequently leading to an increase of the cell membrane/nanoparticle adhesion) and by reorganizing its cytoskeleton, leading to the releasing of the tension of the cell membrane. The main contribution of this work is the proposal of a novel model for representing the cellular uptake of rigid circular nanoparticles based on an energetic model tailored to take into account the adaptation of the nanoparticle/cell membrane adhesion and of the membrane stress during wrapping. Several coupling models using sigmoidal functions are considered and compared. The study calculations revealed that the results considering constant parameters underestimated the final wrapping degree of the particle by up to 50%. <iframe src="https://publications.waset.org/abstracts/138624.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adhesion" title="adhesion">adhesion</a>, <a href="https://publications.waset.org/abstracts/search?q=cellular%20adaptation" title=" cellular adaptation"> cellular adaptation</a>, <a href="https://publications.waset.org/abstracts/search?q=cellular%20uptake" title=" cellular uptake"> cellular uptake</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanical%20properties" title=" mechanical properties"> mechanical properties</a>, <a href="https://publications.waset.org/abstracts/search?q=tension" title=" tension"> tension</a> </p> <a href="https://publications.waset.org/abstracts/138624/modeling-of-the-cellular-uptake-of-rigid-nanoparticles-investigating-the-influence-of-the-adaptation-of-the-cells-mechanical-properties-during-endocytosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/138624.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">212</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET 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