CINXE.COM

<!DOCTYPE html> <html> <head><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2312,1_50,1_53,1_51,0_2317-HCSds&p=3566a23a" /><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2214,1_16,0_2219,1_17-HCSds&p=3566a23a" /><meta charset="utf-8" /><meta name="viewport" content="width=device-width, initial-scale=0.3" /><link rel="shortcut icon" href="/favicon.ico" /><title> Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar </title><script src="/bundles/jquery?v=uFgEwkmfdwWoDMz6vEeIoql0PDF7uHxE-GEoIW9UY9M1"></script> <script src="/bundles/json2?v=d1Efh1-9UFdw-Pnj4VVUxViXmZK9H1kqbY_kx2U79DM1"></script> <script src="/bundles/site?v=Uby6LDuaSQ1_He97UGZvnGv_wln5mTgGNE3q1RwRMEQ1"></script> <link href="/Style/css?v=moasmn2BWK6Px64tnr4mMXZfX9KqyGOs6yBj9kZctxQ1" rel="stylesheet"/> <script src="/bundles/search?v=oKWBTbQ1Eyu3c78HTcS6WrXwgMWPpz68IXv5mSC3oqQ1"></script>  <script async src="https://www.googletagmanager.com/gtag/js?id=UA-221132522-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag() { dataLayer.push(arguments); } gtag('js', new Date()); gtag('config', 'UA-221132522-1'); </script> <script type="text/javascript"> $(function () { InitCategoryIcon(); AddArticleSearchRecord(); }); </script> <meta name="application-name" content="ReferenceCitationAnalysis" /> <meta name="msapplication-TileColor" content="#bd4100" /> <meta name="description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta property="og:site" content="ReferenceCitationAnalysis" /> <meta property="og:site_name" content="ReferenceCitationAnalysis" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://referencecitationanalysis.com/" /> <meta property="og:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta property="og:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta name="twitter:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://referencecitationanalysis.com/" /> <meta name="twitter:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> </head> <body> <form method="post" action="./search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="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" /> </div> <script type="text/javascript"> //<![CDATA[ var theForm = document.forms['form1']; if (!theForm) { theForm = document.form1; } function __doPostBack(eventTarget, eventArgument) { if (!theForm.onsubmit || (theForm.onsubmit() != false)) { theForm.__EVENTTARGET.value = eventTarget; theForm.__EVENTARGUMENT.value = eventArgument; theForm.submit(); } } //]]> </script> <script src="/WebResource.axd?d=pynGkmcFUV13He1Qd6_TZDkCPVD1CEgIJIwX-djYyD12MdD7MbGguneDtbgL0T4_DTGNirF3uaaW3m5irAIXOA2&t=638628207619783110" type="text/javascript"></script> <script id="dxis_725862373" src="/DXR.axd?r=1_304-HCSds" type="text/javascript"></script><script id="dxis_117419880" src="/DXR.axd?r=1_185-HCSds" type="text/javascript"></script><script id="dxis_2117664241" src="/DXR.axd?r=1_188-HCSds" type="text/javascript"></script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="54D499A9" /> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="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" /> </div> <input type="hidden"/><script id="dxis_1899801520" src="/DXR.axd?r=1_298,1_211,1_221,1_182,1_277,1_198,1_209,1_217,1_190,1_223,1_208,1_290,1_206,1_288,1_212,1_286,1_296,1_299,1_224,1_201,1_216-HCSds" type="text/javascript"></script><table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="ASPxLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="width:0px;vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="ASPxLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="ASPxLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1948350305" type="text/javascript">  </script> <div class="top-part cl"> <div class="top-content" id="top"> <ul class="ul"> <li class="logo fl"> <a href="https://www.wjgnet.com" target="_blank"> <img src="/Contents/Images/Bpg-logo-new.svg" /> </a> </li> <li class="rca-title fl"> <a href="/" class="clearlink"> <img src="../Contents/Images/RCA-Logo.svg" alt="Reference Citation Analysis" /> </a> </li> <li id="PageTopControl_loginContainer" class="logined fr"> <table> <tr> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Login" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Login_I" class="dxb-hb" value="Login" type="submit" name="ctl00$PageTopControl$Login" /><span class="dx-vam">Login</span> </div> </div><script id="dxss_309739120" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_AuthorRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_AuthorRegist_I" class="dxb-hb" value="Scholar Register" type="submit" name="ctl00$PageTopControl$AuthorRegist" /><span class="dx-vam">Scholar Register</span> </div> </div><script id="dxss_216236472" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_BusinessRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_BusinessRegist_I" class="dxb-hb" value="Business Register" type="submit" name="ctl00$PageTopControl$BusinessRegist" /><span class="dx-vam">Business Register</span> </div> </div><script id="dxss_1760396766" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Subscribe" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Subscribe_I" class="dxb-hb" value="Subscribe" type="submit" name="ctl00$PageTopControl$Subscribe" /><span class="dx-vam">Subscribe</span> </div> </div><script id="dxss_1089838522" type="text/javascript">  </script> </td> </tr> </table> </li> </ul> </div> </div> <div class="main-part cl"> <div class="main-search-container"> <div class="search-form search-centered"> <div class="search-component-container"> <ul class="ul cl"> <li class="fl"> <table id="FieldItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="FieldItems_TL">Loading…</span></td> </tr> </table><div id="FieldItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox FieldItems" id="FieldItems"> <tr> <td style="display:none;"><input id="FieldItems_VI" name="FieldItems_VI" type="hidden" value="mesh" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="FieldItems_I" name="ctl00$FieldItems" onfocus="ASPx.EGotFocus('FieldItems')" onblur="ASPx.ELostFocus('FieldItems')" onchange="ASPx.ETextChanged('FieldItems')" value="MESH Heading" type="text" /></td><td id="FieldItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="FieldItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="FieldItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="FieldItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="FieldItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="FieldItems_DDD_L_VI" type="hidden" name="ctl00$FieldItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="FieldItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="FieldItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="FieldItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Article Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Abstract</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Keyword</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Category</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">MESH Heading</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Grant Agency</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">RCAID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">DOI</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMCID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Author</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Affiliation</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Email</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Journal Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">ISSN</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Publisher</td> </tr> </table> </div></td> </tr> </table><script id="dxss_153608340" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1280586772" type="text/javascript">  </script><script id="dxss_14646264" type="text/javascript">  </script> </li> <li class="fl"> <table id="OpeartorItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="OpeartorItems_TL">Loading…</span></td> </tr> </table><div id="OpeartorItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox OpeartorItems" id="OpeartorItems"> <tr> <td style="display:none;"><input id="OpeartorItems_VI" name="OpeartorItems_VI" type="hidden" value="Equals" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="OpeartorItems_I" name="ctl00$OpeartorItems" onfocus="ASPx.EGotFocus('OpeartorItems')" onblur="ASPx.ELostFocus('OpeartorItems')" onchange="ASPx.ETextChanged('OpeartorItems')" value="Equals" type="text" /></td><td id="OpeartorItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="OpeartorItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="OpeartorItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="OpeartorItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="OpeartorItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="OpeartorItems_DDD_L_VI" type="hidden" name="ctl00$OpeartorItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="OpeartorItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="OpeartorItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="OpeartorItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Contains</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Equals</td> </tr> </table> </div></td> </tr> </table><script id="dxss_597138281" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_24426426" type="text/javascript">  </script><script id="dxss_1793334323" type="text/javascript">  </script> </li> <li id="TermInputContainer" class="fl TermInputContainer"> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue input-text SearchTermText dxeTextBoxDefaultWidthSys" id="SearchTerm"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="SearchTerm_I" name="ctl00$SearchTerm" onfocus="ASPx.EGotFocus('SearchTerm')" onblur="ASPx.ELostFocus('SearchTerm')" onchange="ASPx.EValueChanged('SearchTerm')" value="Brain Diseases/drug therapy" type="text" /></td> </tr> </table><script id="dxss_543298418" type="text/javascript">  </script> <span class="search-icon-container"> <a class="search-icon" href="javascript:openCategorySelector(1);"><img src="/Contents/Images/search.png" /></a> </span> </li> <li class="fl"> <div class="dxbButton_MetropolisBlue SearchButton dxbButtonSys dxbTSys" id="SearchArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="SearchArticle_I" class="dxb-hb" value="Find an Article" type="submit" name="ctl00$SearchArticle" /><span class="dx-vam">Find an Article</span> </div> </div><script id="dxss_842240986" type="text/javascript">  </script> </li> </ul> <div class="cl"></div> <div class="search-menu"> <span>Find an Article (55806887)</span>   <a href="/Categories" target="_blank">Find a Category (125)</a>   <a href="/SearchJournal" target="_blank">Find a Journal (6160)</a>   <a href="/searchscholar" target="_blank">Find a Scholar (3725)</a>   <a href="/searchacademicassistant" target="_blank">Find an Academic Assistant (18)</a> </div> <div class="search-menu" style="text-align:center;"> <span>Find an Article PDF (4648657)</span>   <a href="/TodayArticles" target="_self">Today's Articles (6)</a>   <span>Subscriber (50766)</span> </div> </div> </div> </div> <script src="/bundles/UserAcademicAchievement?v=QYKvd9c2mOpOgKt90go7osO6NdxcNzivChzWAq_gw3g1"></script> <script type="text/javascript"> $(function () { try { var sort = getQueryString2('sort'); if (sort != null && sort != '') { if ($("[field='st" + sort + "']").length) { $("[field='st" + sort + "']").addClass("sort-highlight"); } if ($("#" + sort + "sortedCheck").length) { $("#" + sort + "sortedCheck").prop("checked", true); } } $("a.readmore").click(function () { $(this).parent().toggle().next().toggle(); }); $("a.readless").click(function () { $(this).parent().toggle().prev().toggle(); }); var action = getQueryString2('action'); if (action != null && action != '') { if ($("a[name='" + action + "']").length) { $("a[name='" + action + "']").first().click(); } } InitializeResultAnalysisBtn(); } catch (e) { } try { $(".file-container-btn").each(function () { var itemCount = parseInt($(this).attr("item-count")); if (itemCount > 0) { $(this).click(function () { var controlId = $(this).attr("aria-controls"); $("#" + controlId).toggle(); var fa = $(this).children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } }); } }); InitAchievementContents(true); InitYearFacets(); setTimeout(() => setUserContainerBorder(), 1000); setTimeout(() => setUserContainerBorder(), 2000); setTimeout(() => setUserContainerBorder(), 5000); } catch (e) { } AddVisitRecord(2); }); function DeleteArticle(doi) { if (confirm("Confirm Delete the Artilce?")) { LoadingPanel.Show(); try { if (doi != '') { var uri = "/api/BpgUser/DeleteArticle?doi=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, async: false, success: function () { window.location.href = window.location.href; } }); } } catch (e) { } finally { LoadingPanel.Hide(); } } } function Refresh() { CloseEdit(); window.location.href = window.location.href; } function CloseEdit() { pcEditArticleControl.Hide(); } function EditArticle(doi) { pcEditArticleControl.SetContentUrl("/EditUserArticle?Id=" + encodeURIComponent(doi)); pcEditArticleControl.Show(); } function setUserContainerBorder() { try { var leftContainerHeight = $('.user-info-center-container .left-part').outerHeight(); var rightContainerHeight = $('.user-info-center-container .right-part').outerHeight(); if (leftContainerHeight > rightContainerHeight) { $('.user-info-center-container .left-part').css('border-right', '1px solid #C0C0C0'); $('.user-info-center-container .right-part').css('border-left', ''); } else { $('.user-info-center-container .right-part').css('border-left', '1px solid #C0C0C0'); $('.user-info-center-container .left-part').css('border-right', ''); } } catch (e) { } } function ShowUserFriendList() { var expandContainer = $(".expandUserFriend"); $(".user-friend-list").toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function ShowUserContainerList(className, listClassName) { var expandContainer = $("." + className); $("." + listClassName).toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function OpenMessage(id, friendId) { OpenFriendMessage(friendId); $("div[name='countcontainer" + id + "']").hide(); } function DeleteFriend(id) { if (confirm("Confirm Delete the Friend?")) { LoadingPanel.Show(); var uri = "/api/BpgUser/DeleteFriend?id=" + id; $.ajax({ type: "get", url: uri, async: false }).done(function () { window.location.href = window.location.href; }); } } function SelectAllFriend() { $("input[name='checkfriend']").each(function () { $(this).attr("checked", $('#selectAllFriend').prop("checked")); }); onCheckFriendClick(); } function onCheckFriendClick() { var itemArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); }); if (itemArray.length > 0) { $("#BatchMessageContainer").show(); } else { $("#BatchMessageContainer").hide(); } } function SendBatchMessages() { var itemArray = new Array(); var idArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); idArray.push($(this).attr("data-id")); }); if (itemArray.length > 0) { if (itemArray.length == 1) { OpenMessage(idArray[0], itemArray[0]); } else { var friendIds = JSON.stringify(itemArray); OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">2028</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (67)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (486)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Brain Diseases/drug therapy</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <input type="radio" id="aisortedCheck" onclick="SetSorted('ai')" name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <input type="radio" id="citedf6sortedCheck" onclick="SetSorted('citedf6')" name="sortedbycheck" value="citedf6sorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Publication Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div class="refine-btn-container-n cl" id="showFacetsContainer"> <a href="javascript:InitAllFacets();" class="refine-link-btn-right" target="_self">Show more</a> </div> <div id="facetsContainer" class="cl" style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Göver T</b>, Slezak M. Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders. <em class='incite-journal-name' onclick='ShowInCiteJournal(18960);'>Pharmacol Rep</em> 2024;<b>76</b>:1333-1345. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39361217' target='_blank'>39361217</a> DOI: <a href='https://dx.doi.org/10.1007/s43440-024-00654-w' target='_blank'>10.1007/s43440-024-00654-w</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s43440-024-00654-w','39361217', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(1);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s43440-024-00654-w' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18960);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1007/s43440-024-00654-w" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in governing stress-related disorders such as major depressive disorder (MDD), anxiety, and post-traumatic stress disorder. Chronic stress or early life trauma, known risk factors of disease, alter HPA axis activity and pattern of glucocorticoid (GC) secretion. These changes have consequences for physiological processes controlled by glucocorticoid receptor (GR) signaling, such as immune response and metabolism. In the brain, the aberrant GR signaling translates to altered behavior, making the GR pathway a viable target for therapies of stress-related disorders. One of the crucial elements of the pathway is FKBP5, a regulator of GR sensitivity and feedback control within the HPA axis, in which genetic variants were shown to moderate the risk of developing psychiatric conditions. The difficulty in targeting the GR-FKBP5 pathway stems from tailoring the intervention to specific brain regions and cell types, in the context of personalized genetic variations in GR and GR-associated genes, like FKBP5. The development of selective inhibitors, antagonists, and approaches based on targeted protein degradation offer insights into mechanistic aspects of disease and pave the way for improved therapy. These strategies can be employed either independently or in conjunction with conventional medications. Concomitant advancements in personalized drug screening (e.g. in vitro models exploiting induced pluripotent stem cells, iPSCs) bring the potential for optimization of therapy aiming to rescue central deficits originating from the HPA imbalance. In this mini-review, we discuss potential therapeutic strategies targeting GR signaling in stress-related disorders, with a focus on personalized approaches and advancements in drug development. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anxiety%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anxiety</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depressive-like+behavior%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depressive-like behavior</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FKBP51%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FKBP51</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucocorticoid+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucocorticoid receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HPA+axis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HPA axis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Major+depression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Major depression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PROTAC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PROTAC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Glucocorticoid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Glucocorticoid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypothalamo-Hypophyseal+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypothalamo-Hypophyseal System/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tacrolimus+Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tacrolimus Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tacrolimus+Binding+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tacrolimus Binding Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pituitary-Adrenal+System%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pituitary-Adrenal System/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministry+of+Science+and+Higher+Education%2c+Poland%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DWD/6/0306/2022 Ministry of Science and Higher Education, Poland</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Science+Center%2c+Poland%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">020/37/K/NZ3/02783 National Science Center, Poland</a></li></ul> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Ji M</b>, Li L, Yu J, Wu Z, Sheng Y, Wang F. New insights into the function and therapeutic potential of RNA-binding protein TRBP in viral infection, chronic metabolic diseases, brain disorders and cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(16199);'>Life Sci</em> 2024;<b>358</b>:123159. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39447729' target='_blank'>39447729</a> DOI: <a href='https://dx.doi.org/10.1016/j.lfs.2024.123159' target='_blank'>10.1016/j.lfs.2024.123159</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.lfs.2024.123159','39447729', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.lfs.2024.123159' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16199);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/26/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.lfs.2024.123159" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">RNA-binding proteins (RBPs) and non-coding RNAs are crucial trans-acting factors that bind to specific cis-acting elements in mRNAs, thereby regulating their stability and translation. The trans-activation response (TAR) RNA-binding protein (TRBP) recognizes precursor microRNAs (pre-miRNAs), modulates miRNA maturation, and influences miRNA interference (mi-RNAi) mediated by the RNA-induced silencing complex (RISC). TRBP also directly binds and mediates the degradation of certain mRNAs. Thus, TRBP acts as a hub for regulating gene expression and influences a variety of biological processes, including immune evasion, metabolic abnormalities, stress response, angiogenesis, hypoxia, and metastasis. Aberrant TRBP expression has been proven to be closely related to the initiation and progression of diseases, such as viral infection, chronic metabolic diseases, brain disorders, and cancer. This review summarizes the roles of TRBP in cancer and other diseases, the therapeutic potential of TRBP inhibition, and the current status of drug discovery on TRBP. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+discovery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug discovery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RISC%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RISC</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TRBP%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TRBP</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-Binding+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-Binding Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Diseases%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Diseases/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Virus+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Virus Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Virus+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Virus Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chronic+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chronic Disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Wang J</b>, Jia R, Wan W, Han H, Wang G, Li Z, Li J. Drug Delivery Targeting Neuroinflammation to Treat Brain Diseases. <em class='incite-journal-name' onclick='ShowInCiteJournal(3443);'>Bioconjug Chem</em> 2024;<b>35</b>:1687-1698. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39377704' target='_blank'>39377704</a> DOI: <a href='https://dx.doi.org/10.1021/acs.bioconjchem.4c00414' target='_blank'>10.1021/acs.bioconjchem.4c00414</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1021/acs.bioconjchem.4c00414','39377704', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1021/acs.bioconjchem.4c00414' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3443);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1021/acs.bioconjchem.4c00414" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Inflammation within the brain is a hallmark of a wide range of brain diseases. The complex role of inflammatory processes in these conditions suggests that neuroinflammation could be a valuable therapeutic target. While several promising anti-inflammatory agents have been identified, their clinical application in brain diseases is often hampered by the inability to cross the blood-brain barrier (BBB) and reach therapeutically effective concentrations at the pathological sites. This limitation highlights the urgent need for effective BBB-penetrating drug delivery systems designed to target brain inflammation. This review critically examines the recent advances over the past five years in drug delivery strategies aimed at mitigating brain inflammation in Alzheimer's disease and ischemic stroke─two of the leading causes of death and disability worldwide. Additionally, we address the key challenges in this field, offering insights into future directions for targeting neuroinflammation in the treatment of brain diseases. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/drug therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Zubko LEBDM</b>, Brandão LA, Disserol CCD, Nascimento II, Paola LD. Reversible ifosfamide-induced encephalopathy with bursts of triphasic waves responsive to levetiracetam. <em>ARQUIVOS DE NEURO-PSIQUIATRIA</em> 2024;<b>82</b>:1-3. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39222927' target='_blank'>39222927</a> DOI: <a href='https://dx.doi.org/10.1055/s-0044-1789267' target='_blank'>10.1055/s-0044-1789267</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1055/s-0044-1789267','39222927', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1055/s-0044-1789267' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1055/s-0044-1789267" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Levetiracetam%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Levetiracetam/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticonvulsants%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticonvulsants/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2c+Alkylating%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents, Alkylating/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ifosfamide%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ifosfamide/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Piracetam%2fanalogs+%26amp%3b+derivatives%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Piracetam/analogs & derivatives</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Piracetam%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Piracetam/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Piracetam%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Piracetam/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroencephalography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroencephalography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Tao Z</b>, Li P, Zhao X. Progress on the Mechanisms and Neuroprotective Benefits of Dexmedetomidine in Brain Diseases. <em class='incite-journal-name' onclick='ShowInCiteJournal(4002);'>Brain Behav</em> 2024;<b>14</b>:e70116. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39482839' target='_blank'>39482839</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527817' target='_blank'>PMC11527817</a> DOI: <a href='https://dx.doi.org/10.1002/brb3.70116' target='_blank'>10.1002/brb3.70116</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/brb3.70116','39482839', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/brb3.70116' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4002);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/brainandbehavior' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/03/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1002/brb3.70116" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Dexmedetomidine, a highly specific α2 agonist, has been extensively utilized in clinical sedation and surgical anesthesia since its introduction in 2000 due to its excellent sympatholytic, sedative, and analgesic effects. This review aimed to identify new approaches for the treatment of patients with brain disorders by thoroughly describing the mechanism of action of dexmedetomidine and examining its neuroprotective effects from the standpoints of basic and clinical research. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The PubMed and Web of Science databases were searched using the keywords dexmedetomidine and related brain diseases, although relevant articles from the last decade were included for detailed summarization and analysis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Dexmedetomidine has shown strong neuroprotective effects, such as protection of the blood-brain barrier, decreased neuronal death, maintained hemodynamic stability, and reduced postoperative agitation and cognitive dysfunction. Furthermore, dexmedetomidine has been shown to exert various neuroprotective effects, including anti-inflammatory and antioxidative stress effects, modulation of autophagy, and reduction of apoptosis in cerebral diseases. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Dexmedetomidine acts as a neuroprotective agent against brain diseases during all phases of treatment. However, clinical trials with larger sample sizes are required to optimize dosage and dosing strategies. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dexmedetomidine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dexmedetomidine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22intracerebral+hemorrhage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">intracerebral hemorrhage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuropathic+pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuropathic pain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22stroke%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">stroke</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22subarachnoid+hemorrhage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">subarachnoid hemorrhage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22traumatic+brain+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">traumatic brain injury</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dexmedetomidine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dexmedetomidine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fprevention+%26amp%3b+control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/prevention & control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adrenergic+alpha-2+Receptor+Agonists%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adrenergic alpha-2 Receptor Agonists/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Qiao L</b>, Du X, Wang H, Wang Z, Gao S, Zhao CQ. Research Progress on the Strategies for Crossing the Blood-Brain Barrier. <em class='incite-journal-name' onclick='ShowInCiteJournal(17435);'>Mol Pharm</em> 2024;<b>21</b>:4786-4803. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39231367' target='_blank'>39231367</a> DOI: <a href='https://dx.doi.org/10.1021/acs.molpharmaceut.4c00447' target='_blank'>10.1021/acs.molpharmaceut.4c00447</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1021/acs.molpharmaceut.4c00447','39231367', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1021/acs.molpharmaceut.4c00447' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17435);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1021/acs.molpharmaceut.4c00447" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Recently, the incidence of brain diseases, such as central nervous system degenerative diseases, brain tumors, and cerebrovascular diseases, has increased. However, the blood-brain barrier (BBB) limits the effective delivery of drugs to brain disease areas. Therefore, the mainstream direction of new drug development for these diseases is to engineer drugs that can better cross the BBB to exert their effects in the brain. This paper reviews the research progress and application of the main trans-BBB drug delivery strategies (receptor/transporter-mediated BBB crossing, focused ultrasound to open the BBB, adenosine agonist reversible opening of the BBB, aromatic resuscitation, transnasal administration, cell-mediated trans-BBB crossing, and viral vector system-mediated brain drug delivery). Meanwhile, the potential applications, advantages, and disadvantages of these strategies for crossing the BBB are analyzed. Finally, the future development prospects of strategies for crossing the BBB are also discussed. These strategies have potential value for treating brain diseases. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22BBB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">BBB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22brain+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">brain diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+delivery+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug delivery system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22trans-BBB+strategies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">trans-BBB strategies</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biological+Transport%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biological Transport/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Si W</b>, Li Y, Du G. Case report: Rare Guillain-Barré syndrome variants and mild encephalitis/encephalopathy with a reversible splenial lesion as the para-infectious manifestations of SARS-CoV-2 infection. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1458231. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39430766' target='_blank'>39430766</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486701' target='_blank'>PMC11486701</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1458231' target='_blank'>10.3389/fimmu.2024.1458231</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1458231','39430766', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2024.1458231' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1458231');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.3389/fimmu.2024.1458231" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">The Coronavirus disease 19 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a threat to human health. Although the COVID-19 pandemic is finished, some peoples are still suffering from this disease. Herein, we report the first case of SARS-CoV-2-associated Guillain-Barré syndrome (GBS) presenting as polyneuritis cranialis (PNC) and acute panautonomic neuropathy (APN) variants, accompanied by mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and hyponatremia. </div><div class="abstract-label">Case presentation</div><div class="abstract-content">A 32-year-old female patient with symptoms indicating multiple cranial nerve involvement, as well as sympathetic and parasympathetic nervous system dysfunction, was diagnosed as SARS-CoV-2-associated GBS presenting as PNC and APN variants, accompanied by MERS and hyponatremia. Following treatment with immunoglobulin, methylprednisolone, and symptomatic care, the patient's inflammatory cytokines and serum sodium became normal. However, some residual symptoms such as postural hypotension, fatigue, and mild dysarthria persisted at the 9-month follow-up. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">This case highlights the unique presentation of SARS-CoV-2 infection. The involvement of both the central nervous system (CNS) and the peripheral nervous system (PNS) in this case underscores the complex neurological manifestations of COVID-19. Although the exact underlying pathogenesis of this case is unclear, inflammatory cytokines, particularly IL-6, may be implicated. Further research is needed to better understand the mechanisms underlying these complications and to optimize treatment strategies for affected patients. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Guillain-Barr%c3%a9+syndrome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Guillain-Barré syndrome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22acute+panautonomic+neuropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">acute panautonomic neuropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22case+report%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">case report</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polyneuritis+cranialis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polyneuritis cranialis</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Guillain-Barre+Syndrome%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Guillain-Barre Syndrome/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Guillain-Barre+Syndrome%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Guillain-Barre Syndrome/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Encephalitis%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Encephalitis/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Encephalitis%2fvirology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Encephalitis/virology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Encephalitis%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Encephalitis/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Corpus+Callosum%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Corpus Callosum/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Corpus+Callosum%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Corpus Callosum/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyponatremia%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyponatremia/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyponatremia%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyponatremia/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fvirology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/virology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Cheng X</b>, Tan Y, Li H, Zhang Z, Hui S, Zhang Z, Peng W. Mechanistic Insights and Potential Therapeutic Implications of NRF2 in Diabetic Encephalopathy. <em class='incite-journal-name' onclick='ShowInCiteJournal(17033);'>Mol Neurobiol</em> 2024;<b>61</b>:8253-8278. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38483656' target='_blank'>38483656</a> DOI: <a href='https://dx.doi.org/10.1007/s12035-024-04097-5' target='_blank'>10.1007/s12035-024-04097-5</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1007%2fs12035-024-04097-5%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1007%2fs12035-024-04097-5')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12035-024-04097-5','38483656', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s12035-024-04097-5' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17033);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/01/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1007/s12035-024-04097-5" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Diabetic encephalopathy (DE) is a complication of diabetes, especially type 2 diabetes (T2D), characterized by damage in the central nervous system and cognitive impairment, which has gained global attention. Despite the extensive research aimed at enhancing our understanding of DE, the underlying mechanism of occurrence and development of DE has not been established. Mounting evidence has demonstrated a close correlation between DE and various factors, such as Alzheimer's disease-like pathological changes, insulin resistance, inflammation, and oxidative stress. Of interest, nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor with antioxidant properties that is crucial in maintaining redox homeostasis and regulating inflammatory responses. The activation and regulatory mechanisms of NRF2 are a relatively complex process. NRF2 is involved in the regulation of multiple metabolic pathways and confers neuroprotective functions. Multiple studies have provided evidence demonstrating the significant involvement of NRF2 as a critical transcription factor in the progression of DE. Additionally, various molecules capable of activating NRF2 expression have shown potential in ameliorating DE. Therefore, it is intriguing to consider NRF2 as a potential target for the treatment of DE. In this review, we aim to shed light on the role and the possible underlying mechanism of NRF2 in DE. Furthermore, we provide an overview of the current research landscape and address the challenges associated with using NRF2 activators as potential treatment options for DE. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+impairment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive impairment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NRF2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NRF2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress+and+inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress and inflammation</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Complications%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Complications/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-E2-Related+Factor+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-E2-Related Factor 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No. 81873169 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82104967 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hunan+Youth+Science+and+Technology+Innovation+Talent+Project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No.2022RC1220 Hunan Youth Science and Technology Innovation Talent Project</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Postdoctoral+Research+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No.2022M711733 Postdoctoral Research Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of%c2%a0Hunan+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No.2020JJ4803 Natural Science Foundation of Hunan Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of%c2%a0Hunan+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022JJ40728 Natural Science Foundation of Hunan Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hunan+Flagship+Department+of+Integrated+Traditional+Chinese+and+Western+Medicine%2c+Hunan+Scientific+Research+Program+of+traditional+Chinese+Medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">No.2021192 Hunan Flagship Department of Integrated Traditional Chinese and Western Medicine, Hunan Scientific Research Program of traditional Chinese Medicine</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Khodaverdi K</b>, Bakhshi A, Mozafari MR, Naghib SM. A review of chitosan-based nanocarriers as drug delivery systems for brain diseases: Critical challenges, outlooks and promises. <em class='incite-journal-name' onclick='ShowInCiteJournal(11467);'>Int J Biol Macromol</em> 2024;<b>278</b>:134962. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39179064' target='_blank'>39179064</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijbiomac.2024.134962' target='_blank'>10.1016/j.ijbiomac.2024.134962</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijbiomac.2024.134962','39179064', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ijbiomac.2024.134962' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11467);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/26/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.ijbiomac.2024.134962" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The administration of medicinal drugs orally or systemically limits the treatment of specific central nervous system (CNS) illnesses, such as certain types of brain cancers. These methods can lead to severe adverse reactions and inadequate transport of drugs to the brain, resulting in limited effectiveness. The CNS homeostasis is maintained by various barriers within the brain, such as the endothelial, epithelial, mesothelial, and glial barriers, which strictly control the movement of chemicals, solutes, and immune cells. Brain capillaries consist of endothelial cells (ECs) and perivascular pericytes, with pericytes playing a crucial role in maintaining the blood-brain barrier (BBB), influencing new blood vessel formation, and exhibiting secretory capabilities. This article summarizes the structural components and anatomical characteristics of the BBB. Intranasal administration, a non-invasive method, allows drugs to reach the brain by bypassing the BBB, while direct cerebral administration targets specific brain regions with high concentrations of therapeutic drugs. Technical and mechanical tools now exist to bypass the BBB, enabling the development of more potent and safer medications for neurological disorders. This review also covers clinical trials, formulations, challenges, and patents for a comprehensive perspective. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-brain+barrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-brain barrier</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Central+nervous+system%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Central nervous system</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chitosan+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chitosan nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodegenerative+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodegenerative diseases</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Carriers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Carriers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chitosan%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chitosan/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Lofts A</b>, Campea MA, Winterhelt E, Rigg N, Rivera NP, Macdonald C, Frey BN, Mishra RK, Hoare T. In situ-gelling hydrophobized starch nanoparticle-based nanoparticle network hydrogels for the effective delivery of intranasal olanzapine to treat brain disorders. <em class='incite-journal-name' onclick='ShowInCiteJournal(11467);'>Int J Biol Macromol</em> 2024;<b>277</b>:134385. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39111489' target='_blank'>39111489</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijbiomac.2024.134385' target='_blank'>10.1016/j.ijbiomac.2024.134385</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijbiomac.2024.134385','39111489', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ijbiomac.2024.134385' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11467);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.ijbiomac.2024.134385" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Intranasal (IN) delivery offers potential to deliver antipsychotic drugs with improved efficacy to the brain. However, the solubilization of such drugs and the frequency of required re-application both represent challenges to its practical implementation in treating various mental illnesses including schizophrenia. Herein, we report a sprayable nanoparticle network hydrogel (NNH) consisting of hydrophobically-modified starch nanoparticles (SNPs) and mucoadhesive chitosan oligosaccharide lactate (COL) that can gel in situ within the nasal cavity and release ultra-small penetrative SNPs over time. Hydrophobization of the SNPs enables enhanced uptake and prolonged release of poorly water soluble drugs such as olanzapine from the NNH depot through mucous and ultimately into the brain via the nose-to-brain (N2B) pathway. The hydrogel shows high in vitro cytocompatibility in mouse striatal neuron and human primary nasal cell lines and in vivo efficacy in an amphetamine-induced pre-clinical rat schizophrenia model, with IN-delivered NNH hydrogels maintaining successful attenuation of locomotor activity for up to 4 h while all other tested treatments (drug-only IN or conventional intraperitoneal delivery) failed to attenuate at any time point past 0.5 h. As such, in situ-gelling NNHs represent a safe excipient for the IN delivery of hydrophobic drugs directly to the brain using customized SNPs that exhibit high penetration and drug complexing properties to maximize effective drug delivery. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intranasal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intranasal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Starch+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Starch nanoparticles</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Administration%2c+Intranasal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Administration, Intranasal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Starch%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Starch/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Olanzapine%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Olanzapine/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Olanzapine%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Olanzapine/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Olanzapine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Olanzapine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrophobic+and+Hydrophilic+Interactions%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrophobic and Hydrophilic Interactions</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schizophrenia%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schizophrenia/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Carriers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Carriers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antipsychotic+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antipsychotic Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antipsychotic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antipsychotic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antipsychotic+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antipsychotic Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chitosan%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chitosan/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Talebi Kiasari F</b>, Naghshbandi M, Emamikhah M, Moradi Moghaddam O, Niakan Lahiji M, Rohani M, Yazdi N, Movahedi H, Amanollahi A, Irandoost P, Ghafoury R. Evaluation of the effect of Modafinil in the improvement of the level of consciousness in patients with COVID-19 encephalopathy: A randomized controlled trial. <em class='incite-journal-name' onclick='ShowInCiteJournal(168078);'>Neuropsychopharmacol Rep</em> 2024;<b>44</b>:490-501. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38715471' target='_blank'>38715471</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544445' target='_blank'>PMC11544445</a> DOI: <a href='https://dx.doi.org/10.1002/npr2.12447' target='_blank'>10.1002/npr2.12447</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/npr2.12447','38715471', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/npr2.12447' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168078);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/09/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1002/npr2.12447" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIM</div><div class="abstract-content">COVID-19 can lead to encephalopathy and loss of consciousness. This double-blinded randomized clinical trial conducted in Tehran, Iran, aimed to assess the potential effectiveness of modafinil in patients with COVID-19-related encephalopathy. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Nineteen non-intubated COVID-19 patients with encephalopathy were randomized into two groups: a treatment group receiving crushed modafinil tablets and a placebo group receiving starch powder. Modafinil was administered at a dose of 100 mg every 2 h, reaching a peak dosage of 400 mg. The level of consciousness was assessed using the Glasgow Coma Score (GCS) at multiple time points on the day of medication administration. The trial was registered under IRCT20170903036041N3 on 23/5/2021. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The average age in the modafinil and placebo groups was 75.33 and 70 years, respectively. No significant differences were observed between the two groups in terms of chronic conditions, clinical symptoms, or laboratory data. GCS scores were similar between the groups at baseline (p-value = 0.699). After four doses of modafinil, GCS scores were slightly higher in the treatment group, but this difference was not statistically significant (p-value = 0.581). GCS scores after each round of drug administration didn't significantly differ between the treatment and placebo groups (p-value = 0.908). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Modafinil exhibited a slight improvement in the level of consciousness among COVID-19 patients with encephalopathy, although this improvement did not reach statistical significance when compared to the control group. Further research with larger sample sizes and longer treatment durations is recommended to explore modafinil's potential benefits in managing altered consciousness in COVID-19 patients. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID%e2%80%9019%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID‐19</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Modafinil%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Modafinil</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22encephalopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">encephalopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22loss+of+consciousness%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">loss of consciousness</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Modafinil%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Modafinil/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Modafinil%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Modafinil/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Double-Blind+Method%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Double-Blind Method</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Consciousness%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Consciousness/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19+Drug+Treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19 Drug Treatment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iran%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iran</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wakefulness-Promoting+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wakefulness-Promoting Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%2c+80+and+over%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged, 80 and over</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glasgow+Coma+Scale%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glasgow Coma Scale</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Fu Q</b>, Song Y, Ling Z, Liu J, Kong Q, Hao X, Xu T, Zhang Q, Liu Y. Regulatory Role of NF-κB on HDAC2 and Tau Hyperphosphorylation in Diabetic Encephalopathy and the Therapeutic Potential of Luteolin. <em class='incite-journal-name' onclick='ShowInCiteJournal(7890);'>Diabetes</em> 2024;<b>73</b>:1513-1526. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38869375' target='_blank'>38869375</a> DOI: <a href='https://dx.doi.org/10.2337/db23-0969' target='_blank'>10.2337/db23-0969</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2337/db23-0969','38869375', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(12);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.2337/db23-0969' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7890);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/diabetes' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/14/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.2337/db23-0969" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Diabetic encephalopathy (DE) is a severe complication of the central nervous system associated with diabetes. In this study, we investigated the regulatory role of mammalian target of rapamycin (mTOR) on nuclear factor κB (NF-κB) in mice with DE, and the neuroprotective effect and therapeutic mechanisms of luteolin, a natural flavonoid compound with anti-inflammatory, antioxidant, and neuroprotective properties. The results indicated that treatment with luteolin improved the degree of cognitive impairment in mice with DE. It also decreased the levels of phosphorylated mTOR, phosphorylated NF-κB, and histone deacetylase 2 (HDAC2) and increased the expression of brain-derived neurotrophic factor and synaptic-related proteins. Furthermore, protein-protein interaction and the Gene Ontology analysis revealed that luteolin was involved in the regulatory network of HDAC2 expression through the mTOR/NF-κB signaling cascade. Our bioinformatics and molecular docking results indicated that luteolin may also directly target HDAC2, as an HDAC2 inhibitor, to alleviate DE, complementing mTOR/NF-κB signaling inhibition. Analysis of luteolin's target proteins and their interactions suggest an effect on HDAC2 and cognition. In conclusion, HDAC2 and tau hyperphosphorylation are regulated by the mTOR/NF-κB signaling cascade in DE, and luteolin is found to reverse these effects, demonstrating its protective role in DE. </div><div class="abstract-label">ARTICLE HIGHLIGHTS</div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Luteolin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Luteolin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Luteolin%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Luteolin/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histone+Deacetylase+2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histone Deacetylase 2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tau+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tau Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Complications%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Complications/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Complications%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Complications/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+Dysfunction%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive Dysfunction/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+Dysfunction%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive Dysfunction/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain-Derived+Neurotrophic+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain-Derived Neurotrophic Factor/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82271228 National Natural Science Foundation of China</a></li></ul> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Gurung B</b>, Bhutia TD, Chettri S, Mummadi MK, Bondre VP. Thiamine Responsive Acute Infantile Encephalopathy. <em class='incite-journal-name' onclick='ShowInCiteJournal(11021);'>Indian J Pediatr</em> 2024;<b>91</b>:964-966. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37880470' target='_blank'>37880470</a> DOI: <a href='https://dx.doi.org/10.1007/s12098-023-04889-y' target='_blank'>10.1007/s12098-023-04889-y</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12098-023-04889-y','37880470', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s12098-023-04889-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11021);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/ijpe/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/27/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1007/s12098-023-04889-y" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This retrospective study was conducted to describe clinical and investigational findings and to determine the effect of thiamine treatment on mortality in patients admitted with acute non-infectious encephalopathy to a hospital in Sikkim between October 2019 and March 2021. Amongst 37 included patients the median age was 4 mo (IQR 3-5), 62.2% were males, 75% were exclusively breastfed infants, 67.6% and 89.2% patients had ophthalmologic and respiratory abnormalities respectively. Multisystem involvement was common. Bilateral basal ganglia involvement was noted in 75% of neuroimaging. Biochemical thiamine deficiency was confirmed in one infant. None of the 11 patients who received thiamine died whereas 20 among 26 patients who did not receive thiamine died [case fatality rate (CFR) 76.9%]. Thiamine treatment was significantly associated with reduced odds of mortality (aOR 0.046, 95% CI 0.0024-0.86, p 0.039). In patients with acute non-infectious encephalopathy and bilateral basal ganglia involvement thiamine use was associated with decreased mortality. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+infantile+encephalopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute infantile encephalopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bilateral+basal+ganglia+involvement%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bilateral basal ganglia involvement</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant+mortality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant mortality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nutrition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nutrition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thiamine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thiamine</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thiamine%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thiamine/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thiamine+Deficiency%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thiamine Deficiency/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thiamine+Deficiency%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thiamine Deficiency/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vitamin+B+Complex%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vitamin B Complex/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+Disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute Disease</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Sierri G</b>, Patrucco M, Ferrario D, Renda A, Comi S, Ciprandi M, Fontanini V, Sica FS, Sesana S, Costa Verdugo M, Kravicz M, Salassa L, Busnelli M, Re F. Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine. <em>WILEY INTERDISCIPLINARY REVIEWS. NANOMEDICINE AND NANOBIOTECHNOLOGY</em> 2024;<b>16</b>:e1991. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39251878' target='_blank'>39251878</a> DOI: <a href='https://dx.doi.org/10.1002/wnan.1991' target='_blank'>10.1002/wnan.1991</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/wnan.1991','39251878', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(14);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/wnan.1991' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1002/wnan.1991" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Numerous studies are focused on nanoparticle penetration into the brain functionalizing them with ligands useful to cross the blood-brain barrier. However, cell targeting is also crucial, given that cerebral pathologies frequently affect specific brain cells or areas. Functionalize nanoparticles with the most appropriate targeting elements, tailor their physical parameters, and consider the brain's complex anatomy are essential aspects for precise therapy and diagnosis. In this review, we addressed the state of the art on targeted nanoparticles for drug delivery in diseased brain regions, outlining progress, limitations, and ongoing challenges. We also provide a summary and overview of general design principles that can be applied to nanotherapies, considering the areas and cell types affected by the most common brain disorders. We then emphasize lingering uncertainties that hinder the translational possibilities of nanotherapies for clinical use. Finally, we offer suggestions for continuing preclinical investigations to enhance the overall effectiveness of precision nanomedicine in addressing neurological conditions. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22blood%e2%80%93brain+barrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">blood–brain barrier</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22brain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">brain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nanomedicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nanomedicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22targeted+drug+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">targeted drug delivery</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanomedicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanomedicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Precision+Medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Precision Medicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Italian+Ministry+of+University+and+Research%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PRIN 2022YJSMBX Italian Ministry of University and Research</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22European+Union%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CUP H53D23006320006 European Union</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spanish+State+Research+Agency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PID2022-139267OB-I00 Spanish State Research Agency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5c%22Severo+Ochoa%5c%22+Programme+for+Centres+of+Excellence+in+R%26D%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CEX2018-000867-S "Severo Ochoa" Programme for Centres of Excellence in R&D</a></li></ul> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Liu S</b>, Zhou S. Lactate: A New Target for Brain Disorders. <em class='incite-journal-name' onclick='ShowInCiteJournal(17983);'>Neuroscience</em> 2024;<b>552</b>:100-111. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38936457' target='_blank'>38936457</a> DOI: <a href='https://dx.doi.org/10.1016/j.neuroscience.2024.06.023' target='_blank'>10.1016/j.neuroscience.2024.06.023</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.neuroscience.2024.06.023','38936457', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.neuroscience.2024.06.023' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17983);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/29/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.neuroscience.2024.06.023" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Lactate in the brain is produced endogenously and exogenously. The primary functional cells that produce lactate in the brain are astrocytes. Astrocytes release lactate to act on neurons, thereby affecting neuronal function, through a process known as the astrocyte-neuron shuttle. Lactate affects microglial function as well and inhibits microglia-mediated neuroinflammation. Lactate also provides energy, acts as a signaling molecule, and promotes neurogenesis. This article summarizes the role of lactate in cells, animals, and humans. Lactate is a protective molecule against stress in healthy organisms and in the early stages of brain disorders. Thus, lactate may be a potential therapeutic target for brain disorders. Further research on the role of lactate in microglia may have great prospects. This article provides a new perspective and research direction for the study of lacate in brain disorders. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22depression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">depression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lactate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lactate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microglia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microglia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuroinflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuroinflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22signaling+molecules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">signaling molecules</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lactic+Acid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lactic Acid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Astrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Astrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microglia%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microglia/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Miao K</b>, Xia X, Zou Y, Shi B. Small Scale, Big Impact: Nanotechnology-Enhanced Drug Delivery for Brain Diseases. <em class='incite-journal-name' onclick='ShowInCiteJournal(17435);'>Mol Pharm</em> 2024;<b>21</b>:3777-3799. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39038108' target='_blank'>39038108</a> DOI: <a href='https://dx.doi.org/10.1021/acs.molpharmaceut.4c00387' target='_blank'>10.1021/acs.molpharmaceut.4c00387</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1021/acs.molpharmaceut.4c00387','39038108', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1021/acs.molpharmaceut.4c00387' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17435);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1021/acs.molpharmaceut.4c00387" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Central nervous system (CNS) diseases, ranging from brain cancers to neurodegenerative disorders like dementia and acute conditions such as strokes, have been heavily burdening healthcare and have a direct impact on patient quality of life. A significant hurdle in developing effective treatments is the presence of the blood-brain barrier (BBB), a highly selective barrier that prevents most drugs from reaching the brain. The tight junctions and adherens junctions between the endothelial cells and various receptors expressed on the cells make the BBB form a nonfenestrated and highly selective structure that is crucial for brain homeostasis but complicates drug delivery. Nanotechnology offers a novel pathway to circumvent this barrier, with nanoparticles engineered to ferry drugs across the BBB, protect drugs from degradation, and deliver medications to the designated area. After years of development, nanoparticle optimization, including sizes, shapes, surface modifications, and targeting ligands, can enable nanomaterials tailored to specific brain drug delivery settings. Moreover, smart nano drug delivery systems can respond to endogenous and exogenous stimuli that control subsequent drug release. Here, we address the importance of the BBB in brain disease treatment, summarize different delivery routes for brain drug delivery, discuss the cutting-edge nanotechnology-based strategies for brain drug delivery, and further offer valuable insights into how these innovations in nanoparticle technology could revolutionize the treatment of CNS diseases, presenting a promising avenue for noninvasive, targeted therapeutic interventions. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22blood%e2%88%92brain+barrier+(BBB)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">blood−brain barrier (BBB)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22brain+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">brain diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22central+nervous+system+(CNS)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">central nervous system (CNS)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nanoparticles</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanotechnology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanotechnology/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticle+Drug+Delivery+System%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticle Drug Delivery System/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Liu K</b>, Pang T. Commentary: brain endothelial GSDMD as a novel target for brain disorders associated with BBB damage. <em class='incite-journal-name' onclick='ShowInCiteJournal(6330);'>Chin J Nat Med</em> 2024;<b>22</b>:580-581. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39059827' target='_blank'>39059827</a> DOI: <a href='https://dx.doi.org/10.1016/s1875-5364(24)60616-3' target='_blank'>10.1016/s1875-5364(24)60616-3</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/s1875-5364(24)60616-3','39059827', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/s1875-5364(24)60616-3' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(6330);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/s1875-5364(24)60616-3" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-brain+barrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-brain barrier</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+disorders%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain disorders</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+endothelial+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain endothelial cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GSDMD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GSDMD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+products%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural products</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammation</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphate-Binding+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphate-Binding Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endothelial+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endothelial Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endothelial+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endothelial Cells/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Pempera N</b>, Miedziaszczyk M, Lacka K. Difficulties in the Diagnostics and Treatment of Hashimoto's Encephalopathy-A Systematic and Critical Review. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2024;<b>25</b>:7101. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39000209' target='_blank'>39000209</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11241003' target='_blank'>PMC11241003</a> DOI: <a href='https://dx.doi.org/10.3390/ijms25137101' target='_blank'>10.3390/ijms25137101</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms25137101','39000209', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms25137101' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/ijms25137101');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.3390/ijms25137101" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Hashimoto's encephalopathy (HE) has been a poorly understood disease. It has been described in all age group, yet, there is no specific HE marker. Additionally, the treatment data in the available studies are frequently divergent and contradictory. Therefore, the aim of our systematic and critical review is to evaluate the diagnosis and treatment of HE in view of the latest findings. The databases browsed comprised PubMed, Scopus, and Google Scholar as well as Cochrane Library, and the search strategy included controlled vocabulary and keywords. A total of 2443 manuscripts were found, published since the beginning of HE research until February 2024. In order to determine validity of the data collected from studies, bias assessment was performed using RoB 2 tool. Ultimately, six studies were included in our study. HE should be considered in the differential diagnosis in patients with psychiatric and neurological symptoms. According to our findings, negative thyroid peroxidase antibodies (anti-TPOs) may represent a valuable parameter in ruling out HE. Nonetheless, this result cannot be used to confirm HE. Furthermore, the proposed anti NH2-terminal-α-enolase (anti-NAE) is non-specific for HE. The effectiveness of glucocorticoid therapy is 60.94%, although relapse occurs in 31.67% of patients following the treatment. Our review emphasizes the significance of conducting further large-scale research and the need to take into account the potential genetic factor. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hashimoto%e2%80%99s+thyroiditis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hashimoto’s thyroiditis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anti-TPO%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anti-TPO</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22encephalopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">encephalopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22steroid-responsive+encephalopathy+associated+with+autoimmune+thyroiditis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">steroid-responsive encephalopathy associated with autoimmune thyroiditis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22steroidotheraphy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">steroidotheraphy</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hashimoto+Disease%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hashimoto Disease/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hashimoto+Disease%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hashimoto Disease/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hashimoto+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hashimoto Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Encephalitis%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Encephalitis/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Encephalitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Encephalitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Encephalitis%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Encephalitis/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoantibodies%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoantibodies/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoantibodies%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoantibodies/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diagnosis%2c+Differential%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diagnosis, Differential</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glucocorticoids%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glucocorticoids/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iodide+Peroxidase%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iodide Peroxidase/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Gerstner ER</b>, Choi BD, Curry WT. Infusion of CARv3-TEAM-E T Cells in Glioblastoma. Reply. <em class='incite-journal-name' onclick='ShowInCiteJournal(17908);'>N Engl J Med</em> 2024;<b>390</b>:2330-2331. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38924746' target='_blank'>38924746</a> DOI: <a href='https://dx.doi.org/10.1056/nejmc2405721' target='_blank'>10.1056/nejmc2405721</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1056/nejmc2405721','38924746', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1056/nejmc2405721' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17908);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc05.manuscriptcentral.com/nejm' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1056/nejmc2405721" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+Trials%2c+Phase+I+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical Trials, Phase I as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dexamethasone%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dexamethasone/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bevacizumab%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bevacizumab/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bevacizumab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bevacizumab/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Mader DA</b>, Kerrigan D, Pai J. Acute Encephalopathy in a Patient with Raoultella Ornithinolytica Infection: A Challenging Presentation. <em>RHODE ISLAND MEDICAL JOURNAL (2013)</em> 2024;<b>107</b>:7-9. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38810006' target='_blank'>38810006</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('pmid/38810006','38810006', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/31/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="pmid/38810006" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Raoultella ornithinolytica is a rare, gram-negative environmental enterobacterium. Although infections in humans caused by R. ornithinolytica are uncommon, there are increasing reports implicating it in urinary tract infections, hepatobiliary infections, and bacteremia, designating it as an emerging pathogen. Its habitat is primarily in aquatic environments and soil, with seafood frequently identified as a potential source of infection. While these infections have predominantly been described in immunocompromised patients previously, our case suggests that advanced age may be a significant risk factor. We describe a case of a 73-year-old man presenting with encephalopathy who then was found to have R. ornithinolytica bacteremia from a genitourinary source. Following antibiotic treatment, the infection resolved and the neurologic symptoms improved. To the best of our knowledge, this is the first documented case in the medical literature of R. ornithinolytica featuring a primary neurologic presentation. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Raoultella+ornithinolytica%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Raoultella ornithinolytica</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22UTI%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">UTI</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22altered+mental+status%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">altered mental status</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bacteremia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bacteremia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22encephalopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">encephalopathy</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enterobacteriaceae+Infections%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enterobacteriaceae Infections/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enterobacteriaceae+Infections%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enterobacteriaceae Infections/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Bacterial+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Bacterial Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enterobacteriaceae%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enterobacteriaceae/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteremia%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteremia/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteremia%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteremia/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteremia%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteremia/diagnosis</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Liao J</b>, Gong L, Xu Q, Wang J, Yang Y, Zhang S, Dong J, Lin K, Liang Z, Sun Y, Mu Y, Chen Z, Lu Y, Zhang Q, Lin Z. Revolutionizing Neurocare: Biomimetic Nanodelivery Via Cell Membranes. <em>ADVANCED MATERIALS (DEERFIELD BEACH, FLA.)</em> 2024;<b>36</b>:e2402445. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38583077' target='_blank'>38583077</a> DOI: <a href='https://dx.doi.org/10.1002/adma.202402445' target='_blank'>10.1002/adma.202402445</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/adma.202402445','38583077', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/adma.202402445' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/08/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1002/adma.202402445" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Brain disorders represent a significant challenge in medical science due to the formidable blood-brain barrier (BBB), which severely limits the penetration of conventional therapeutics, hindering effective treatment strategies. This review delves into the innovative realm of biomimetic nanodelivery systems, including stem cell-derived nanoghosts, tumor cell membrane-coated nanoparticles, and erythrocyte membrane-based carriers, highlighting their potential to circumvent the BBB's restrictions. By mimicking native cell properties, these nanocarriers emerge as a promising solution for enhancing drug delivery to the brain, offering a strategic advantage in overcoming the barrier's selective permeability. The unique benefits of leveraging cell membranes from various sources is evaluated and advanced technologies for fabricating cell membrane-encapsulated nanoparticles capable of masquerading as endogenous cells are examined. This enables the targeted delivery of a broad spectrum of therapeutic agents, ranging from small molecule drugs to proteins, thereby providing an innovative approach to neurocare. Further, the review contrasts the capabilities and limitations of these biomimetic nanocarriers with traditional delivery methods, underlining their potential to enable targeted, sustained, and minimally invasive treatment modalities. This review is concluded with a perspective on the clinical translation of these biomimetic systems, underscoring their transformative impact on the therapeutic landscape for intractable brain diseases. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomimetic+nanocarriers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomimetic nanocarriers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22blood%e2%80%93brain+barrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">blood–brain barrier</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22brain+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">brain diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+membrane%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell membrane</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22targeted+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">targeted therapy</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Membrane%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Membrane/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Membrane%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Membrane/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetics/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Carriers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Carriers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U20A20412 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">22378004 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Beijing+Municipality%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JQ21038 Natural Science Foundation of Beijing Municipality</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Postdoctoral+Fellowship+Program+of+CPSF%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GZC20230162 Postdoctoral Fellowship Program of CPSF</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Yadav K</b>, Vijayalakshmi R, Kumar Sahu K, Sure P, Chahal K, Yadav R, Sucheta, Dubey A, Jha M, Pradhan M. Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders. <em class='incite-journal-name' onclick='ShowInCiteJournal(8885);'>Eur J Pharm Biopharm</em> 2024;<b>199</b>:114298. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38642716' target='_blank'>38642716</a> DOI: <a href='https://dx.doi.org/10.1016/j.ejpb.2024.114298' target='_blank'>10.1016/j.ejpb.2024.114298</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ejpb.2024.114298','38642716', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ejpb.2024.114298' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8885);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.ejpb.2024.114298" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Delivering drugs to the brain is a complex challenge in medical research, particularly for disorders like Alzheimer's and Parkinson's. The blood-brain barrier restricts the entry of many therapeutic molecules, hindering their effectiveness. Nanoparticles, a potential solution, face issues like toxicity and limited approvals. A new avenue explores the use of small extracellular vesicles (sEVs), i.e., exosomes, as natural carriers for drug delivery. sEVs, tiny structures below 150 nm, show promise due to their minimal immune response and ability to precisely deliver drugs. This review focuses on the potential of sEVs-based drug delivery systems for treating neurological disorders, brain cancers, and other brain-related issues. Notably, bioengineered sEVs-carrying therapeutic compounds exhibit promise in early studies. The unique features of sEVs, such as their small size and natural properties, position them as candidates to overcome challenges in drug delivery to the brain. Ongoing clinical trials and research into sEVs behavior within the body further highlight their potential for revolutionizing drug delivery and addressing complex brain conditions. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood%e2%80%93brain+barrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood–brain barrier</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+disorders%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain disorders</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurotherapeutic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurotherapeutic</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Carriers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Carriers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Austin-Keiller A</b>, Saint-Martin C, Myers KA. Acute encephalopathy with biphasic seizures and late reduced diffusion with concurrent transverse myelitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(8595);'>Epileptic Disord</em> 2024;<b>26</b>:365-368. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38420707' target='_blank'>38420707</a> DOI: <a href='https://dx.doi.org/10.1002/epd2.20212' target='_blank'>10.1002/epd2.20212</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/epd2.20212','38420707', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/epd2.20212' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8595);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/02/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1002/epd2.20212" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">We describe a patient with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) with unique features, including concurrent transverse myelitis. A 2-year-old previously healthy girl had clinical findings consistent with AESD, occurring in association with influenza A infection. The posterior brain regions were most severely affected, resulting in cortical blindness. She also developed bilateral limb weakness, and spine MRI revealed transverse myelitis in the cervical region. She was treated acutely with intravenous methylprednisolone. Serum anti-myelin oligodendrocyte glycoprotein and anti-aquaporin-4 antibodies were negative, as was an anti-extractable nuclear antigen panel. Although her clinical presentation was severe, she improved dramatically over the following months, and 6 months following initial presentation, her parents felt she had returned to baseline. This is the first report of AESD occurring in combination with transverse myelitis. The co-occurrence of the two conditions is unlikely to be coincidental, suggesting that there may be a shared or overlapping immunological pathway involved. The patient's recovery was impressive, which could partially relate to the acute treatment with corticosteroids. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22acute+encephalopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">acute encephalopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22acute+encephalopathy+with+biphasic+seizures+and+late+reduced+diffusion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">acute encephalopathy with biphasic seizures and late reduced diffusion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cortical+blindness%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cortical blindness</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22influenza+A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">influenza A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transverse+myelitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transverse myelitis</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myelitis%2c+Transverse%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myelitis, Transverse/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myelitis%2c+Transverse%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myelitis, Transverse/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Seizures%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Seizures/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Influenza%2c+Human%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Influenza, Human/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methylprednisolone%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methylprednisolone/administration & dosage</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Kakinen A</b>, Jiang Y, Davis TP, Teesalu T, Saarma M. Brain Targeting Nanomedicines: Pitfalls and Promise. <em class='incite-journal-name' onclick='ShowInCiteJournal(11725);'>Int J Nanomedicine</em> 2024;<b>19</b>:4857-4875. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38828195' target='_blank'>38828195</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143448' target='_blank'>PMC11143448</a> DOI: <a href='https://dx.doi.org/10.2147/ijn.s454553' target='_blank'>10.2147/ijn.s454553</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2147/ijn.s454553','38828195', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.2147/ijn.s454553' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/a03c38033a89a0fd8af9e93121990b03/ijn-19-4857.PMC11143448.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.2147/ijn.s454553');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11725);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.2147/ijn.s454553" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Brain diseases are the most devastating problem among the world's increasingly aging population, and the number of patients with neurological diseases is expected to increase in the future. Although methods for delivering drugs to the brain have advanced significantly, none of these approaches provide satisfactory results for the treatment of brain diseases. This remains a challenge due to the unique anatomy and physiology of the brain, including tight regulation and limited access of substances across the blood-brain barrier. Nanoparticles are considered an ideal drug delivery system to hard-to-reach organs such as the brain. The development of new drugs and new nanomaterial-based brain treatments has opened various opportunities for scientists to develop brain-specific delivery systems that could improve treatment outcomes for patients with brain disorders such as Alzheimer's disease, Parkinson's disease, stroke and brain tumors. In this review, we discuss noteworthy literature that examines recent developments in brain-targeted nanomedicines used in the treatment of neurological diseases. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22blood-brain+barrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">blood-brain barrier</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22brain+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">brain delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nanoparticle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nanoparticle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurodegenerative+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurodegenerative diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22stroke%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">stroke</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22targeted+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">targeted delivery</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanomedicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanomedicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticle+Drug+Delivery+System%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticle Drug Delivery System/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticle+Drug+Delivery+System%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticle Drug Delivery System/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parkinson+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parkinson Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alzheimer+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alzheimer Disease/drug therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22the+National+Health+and+Medical+Research+Council+Emerging+Leadership+Fellowship%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">the National Health and Medical Research Council Emerging Leadership Fellowship</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Dhull A</b>, Zhang Z, Sharma R, Dar AI, Rani A, Wei J, Gopalakrishnan S, Ghannam A, Hahn V, Pulukuri AJ, Tasevski S, Moughni S, Wu BJ, Sharma A. Discovery of 2-deoxy glucose surfaced mixed layer dendrimer: a smart neuron targeted systemic drug delivery system for brain diseases. <em class='incite-journal-name' onclick='ShowInCiteJournal(22631);'>Theranostics</em> 2024;<b>14</b>:3221-3245. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38855177' target='_blank'>38855177</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155412' target='_blank'>PMC11155412</a> DOI: <a href='https://dx.doi.org/10.7150/thno.95476' target='_blank'>10.7150/thno.95476</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7150/thno.95476','38855177', 'Brain Diseases/drug therapy')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.7150/thno.95476' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.7150/thno.95476');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22631);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/11/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.7150/thno.95476" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The availability of non-invasive drug delivery systems capable of efficiently transporting bioactive molecules across the blood-brain barrier to specific cells at the injury site in the brain is currently limited. Delivering drugs to neurons presents an even more formidable challenge due to their lower numbers and less phagocytic nature compared to other brain cells. Additionally, the diverse types of neurons, each performing specific functions, necessitate precise targeting of those implicated in the disease. Moreover, the complex synthetic design of drug delivery systems often hinders their clinical translation. The production of nanomaterials at an industrial scale with high reproducibility and purity is particularly challenging. However, overcoming this challenge is possible by designing nanomaterials through a straightforward, facile, and easily reproducible synthetic process. Methods: In this study, we have developed a third-generation 2-deoxy-glucose functionalized mixed layer dendrimer (2DG-D) utilizing biocompatible and cost-effective materials via a highly facile convergent approach, employing copper-catalyzed click chemistry. We further evaluated the systemic neuronal targeting and biodistribution of 2DG-D, and brain delivery of a neuroprotective agent pioglitazone (Pio) in a pediatric traumatic brain injury (TBI) model. Results: The 2DG-D exhibits favorable characteristics including high water solubility, biocompatibility, biological stability, nanoscale size, and a substantial number of end groups suitable for drug conjugation. Upon systemic administration in a pediatric mouse model of traumatic brain injury (TBI), the 2DG-D localizes in neurons at the injured brain site, clears rapidly from off-target locations, effectively delivers Pio, ameliorates neuroinflammation, and improves behavioral outcomes. Conclusions: The promising in vivo results coupled with a convenient synthetic approach for the construction of 2DG-D makes it a potential nanoplatform for addressing brain diseases. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dendrimer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dendrimer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+conjugate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug conjugate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nanotherapeutics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nanotherapeutics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neuron+targeting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neuron targeting</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22non-invasive+brain+targeting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">non-invasive brain targeting</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22targeted+drug+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">targeted drug delivery</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dendrimers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dendrimers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deoxyglucose%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Deoxyglucose/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deoxyglucose%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Deoxyglucose/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pioglitazone%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pioglitazone/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pioglitazone%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pioglitazone/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pioglitazone%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pioglitazone/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Injuries%2c+Traumatic%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Injuries, Traumatic/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Injuries%2c+Traumatic%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Injuries, Traumatic/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+Distribution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue Distribution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li></ul> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> </tbody></table> <div class="search-pager-container"> <div class="dxpLite_MetropolisBlue" id="RootHolder_SearchResultPager" style="margin-top: 20px; margin-bottom: 20px;"> <b class="dxp-lead dxp-button dxp-bi dxp-disabledButton"><img class="dxWeb_pPrevDisabled_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Prev" /></b><b class="dxp-summary" style="margin-left:0px;">Page 1 of 82 </b><b class="dxp-num dxp-current page-number" style="margin-left:0px;">1</b><a class="dxp-num page-number" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">2</a><a class="dxp-num page-number" href="/Search?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3</a><a class="dxp-num page-number" href="/Search?page=4&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4</a><a class="dxp-num page-number" href="/Search?page=5&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">5</a><b class="dxp-ellip" style="margin-left:0px;">…</b><a class="dxp-num page-number" href="/Search?page=81&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">81</a><a class="dxp-num page-number" href="/Search?page=82&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">82</a><a class="dxp-button dxp-bi" onclick="ASPx.PGNav(event);" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;"><img class="dxWeb_pNext_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Next" /></a> </div><b class="dx-clear"></b><script id="dxss_545220915" type="text/javascript">  </script> </div> </div> <div class="cl"></div> </div> </div> </div> <table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="RootHolder_LeftLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Brain Diseases/drug therapy (2028 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Brain Diseases/drug therapy (2028 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>