Hepatology

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name="wkhealth_journal_title" content="Hepatology" /><meta name="wkhealth_journal_title_legacy" content="Hepatology" /><meta name="wkhealth_issue" content="1" /><meta name="wkhealth_article_publication_date" content="November 25, 2014" /><meta name="wkhealth_volume" content="61" /><meta name="wkhealth_ovid_accession_number" content="01515467-201501000-00014" /><meta name="wkhealth_issn" content="0270-9139" /><meta name="wkhealth_title" content="Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors" /><meta name="wkhealth_authors" content="van Bömmel, Florian;Bartens, Anne;Mysickova, Alena;Hofmann, Jörg;Krüger, Detlev H.;Berg, Thomas;Edelmann, Anke" /><meta name="wkhealth_doi" content="10.1002/hep.27381" /><meta name="wkhealth_abstract_html_url" content="https://journals.lww.com/hep/abstract/2015/01000/serum_hepatitis_b_virus_rna_levels_as_an_early.14.aspx" /><meta name="wkhealth_fulltext_html_url" content="https://journals.lww.com/hep/fulltext/2015/01000/serum_hepatitis_b_virus_rna_levels_as_an_early.14.aspx" /><meta name="wkhealth_toc_section" content="Viral Hepatitis" /><meta name="wkhealth_toc_sub_section" /><meta name="wkhealth_eJpId" content="hep:2015:01000:00014" /><meta name="wkhealth_firstpage" content="66" /><meta name="wkhealth_date" content="January 2015" /><meta name="wkhealth_pdf_url" content="https://journals.lww.com/hep/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=Other&an=01515467-201501000-00014" /><meta name="Description" content="Hepatitis B envelope antigen (HBeAg) seroconversion represents an endpoint of treatment of chronic h" /><meta property="og:site_name" content="LWW" /><meta property="og:type" content="article" /><meta property="og:title" content="Serum hepatitis B virus RNA levels as an early predictor of ... : Hepatology" /><meta property="og:description" content="termined in serial serum samples from 62 patients with chronic HBV infection (50 HBeAg positive). Patients received antiviral treatment for a mean duration of 30 ± 15 (range, 4‐64) months. A new rapid amplification of complimentary DNA‐ends‐based real‐time polymerase chain reaction was established for quantitative analysis of polyadenylated full‐length (fl) and truncated (tr) HBV RNA. HBV RNA, HBV DNA, and hepatitis B surface antigen (HBsAg) levels as well as presence of HBeAg and hepatitis B envelope antibody were measured at baseline, month 3, month 6, and subsequent time points. Fifteen patients who achieved HBeAg seroconversion after a mean duration of 19 ± 14 (range, 3‐56) months of antiviral treatment showed a significantly stronger decline in mean HBV flRNA and trRNA levels from baseline to month 3 of 1.0 ± 1.4 (range, −1.6‐3.4) and 2.1 ± 1.4 (range, 0‐3.9) and to month 6 of 1.8 ± 1.4 (range, 0‐4.6) and 3.1 ± 1.7 (range, 0‐5.1) log10 copies/mL, respectively, in comparison to 35 HBeAg‐positive patients without HBeAg seroconversion (P < 0.001 for months 3 and 6). A similar decline in HBV RNA levels was observed in HBeAg‐negative patients. The decline of HBV RNA levels at months 3 and 6 of treatment was to be the strongest predictor of HBeAg seroconversion, when compared to levels of HBV DNA, HBsAg, alanine aminotransferase, and HBV genotype, age, and sex. Conclusion: Serum HBV RNA levels may serve as a novel tool for prediction of serological response during polymerase inhibitor treatment in HBeAg‐positive patients. (Hepatology 2015;61:66–76)..." /><meta property="og:image" content="https://images.journals.lww.com/hep/SocialThumb.01515467-201501000-00014.hep27381-fig-0001.jpeg" /><meta property="og:image:width" content="315" /><meta property="og:image:height" content="250" /><meta property="og:url" content="https://journals.lww.com/hep/fulltext/2015/01000/serum_hepatitis_b_virus_rna_levels_as_an_early.14.aspx" /><meta property="twitter:card" content="summary" /><meta name="robots" content="index, follow, noarchive" /><meta name="WT.sv" content="ZUSE1PEJPWEB03" /><meta name="Title" content="Hepatology" /><style id="SPThemeHideForms" type="text/css">body {opacity:0 !important}</style>  <link href="https://fonts.googleapis.com/css?family=Arvo:400,400i,700|Fira+Sans:300,300i,400,400i,500,500i,600,600i,700,700i&display=swap" rel="stylesheet" /> <script> // temporary workaround for Bug 316328:[Stage][Registration][Regression 05.04] - Omniture events are not displayed for article viewer page // prevents 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mVydGlzZW1lbnQgZWotYWR2ZXJ0aXNlbWVudC1taWRkbGUfAGcWAgIBDxYEHwIF+QI8ZGl2IGlkPSJnYV84ZGQzN2M3ZS1hNGQ0LTRmMzYtODVmOC0yYWI1ZTNjODYzMWEiIGNsYXNzPSJhZC1zbG90LWNvbnRhaW5lciBhZC1zbG90LWNvbnRhaW5lci1nYV84ZGQzN2M3ZS1hNGQ0LTRmMzYtODVmOC0yYWI1ZTNjODYzMWEiIGRhdGEtc2l6ZW1hcD0iW1tbMCwgMF0sIFtbMzAwLCAyNTBdXV1dIiBkYXRhLWFkcGF0aD0iLzE1NzI2NzAyNzYxL0Rlc2t0b3AvaGVwL0FydGljbGUvUmlnaHQiIGRhdGEtYXV0b2xvYWQ9Im5vIiBkYXRhLW91dG9mcGFnZT0ibm8iIGRhdGEtc3RpY2t5PSJubyIgZGF0YS1zbG90dGFyZ2V0aW5nPScnIGRhdGEtZGlzcGxheXNsdWc9InllcyIgZGF0YS1zdGlja3ktZHVyYXRpb249IjAiIGRhdGEtbmFtZT0iUmlnaHQiPjwvZGl2Ph8AZ2QFJmdfZDcyZjYxNWVfMTM3Ml80ZmI1XzgwNzJfOGRkOTg0ODM0NWIxD2QWBGYPFgQfA2QfLAVaeyJzZXJ2aWNlVXJsIjpudWxsLCJkaXNwbGF5TW9kZSI6bnVsbCwiaGFzaCI6IjEiLCJpdGVtc1BlclBhZ2UiOjQwLCJyZW5kZXJPblNlcnZlciI6ZmFsc2V9ZAIBD2QWAmYPZBYCZg8UKwACDxYEHyZnHycCBWRkZAUmZ184OGI2NzgwZl9kZGYwXzRlYjZfYTIyMl8wYWQ2OTczYWYwNWMPZBYCZg9kFgICAg8WBB8DBS1lai1hZHZlcnRpc2VtZW50IGVqLWFkdmVydGlzZW1lbnQtYmFubmVyY29tYm8fAGcWAgIBDxYEHwIF3wM8ZGl2IGlkPSJnYV8yNDkxZGEwZS04ZGYxLTQzMjgtYWM0Yi05YjI5ZDc2OTUxZmEiIGNsYXNzPSJhZC1zbG90LWNvbnRhaW5lciBhZC1zbG90LWNvbnRhaW5lci1nYV8yNDkxZGEwZS04ZGYxLTQzMjgtYWM0Yi05YjI5ZDc2OTUxZmEiIGRhdGEtc2l6ZW1hcD0iW1tbMTA1MCwgMjAwXSwgW1szMDAsIDYwMF0sIFszMDAsIDI1MF0sIFsxNjAsIDYwMF1dXSwgW1s3MzAsIDYwMF0sIFtbMzAwLCA2MDBdLCBbMzAwLCAyNTBdXV0sIFsgWyAwLCAwIF0sIFsgWzMwMCwgMjUwXSBdIF0gXSIgZGF0YS1hZHBhdGg9Ii8xNTcyNjcwMjc2MS9EZXNrdG9wL2hlcC9BcnRpY2xlL1JpZ2h0MSIgZGF0YS1hdXRvbG9hZD0ibm8iIGRhdGEtb3V0b2ZwYWdlPSJubyIgZGF0YS1zdGlja3k9Im5vIiBkYXRhLXNsb3R0YXJnZXRpbmc9JycgZGF0YS1kaXNwbGF5c2x1Zz0ieWVzIiBkYXRhLXN0aWNreS1kdXJhdGlvbj0iMCIgZGF0YS1uYW1lPSJSaWdodDEiPjwvZGl2Ph8AZ2QCCQ8WAh8AaBYCAgUPZBYCAgMPFgIfAGgWAmYPZBYEAgIPZBYGAgEPFgIfAGhkAgMPFgIfAGhkAgUPFgIfAGhkAgMPDxYCHglBY2Nlc3NLZXkFAS9kZAILD2QWAgIBDw8WAh8AaGRkAhMPZBYCAgEPZBYCZg9kFgICAg8WBB8DBSplai1hZHZlcnRpc2VtZW50IGVqLWFkdmVydGlzZW1lbnQtdG9wY29tYm8fAGcWAgIBDxYEHwIFkAM8ZGl2IGlkPSJnYV8yZDU5YjZlMC0xOGEzLTQ4NjQtOTdmMi0yYzA5ZTg4MWZhZmMiIGNsYXNzPSJhZC1zbG90LWNvbnRhaW5lciBhZC1zbG90LWNvbnRhaW5lci1nYV8yZDU5YjZlMC0xOGEzLTQ4NjQtOTdmMi0yYzA5ZTg4MWZhZmMiIGRhdGEtc2l6ZW1hcD0iW1tbNzMwLCA1MDBdLCBbWzcyOCwgOTBdXV0sIFtbMCwgMF0sIFtbMzAwLCA1MF1dXV0iIGRhdGEtYWRwYXRoPSIvMTU3MjY3MDI3NjEvRGVza3RvcC9oZXAvQXJ0aWNsZS9Ub3AiIGRhdGEtYXV0b2xvYWQ9InllcyIgZGF0YS1vdXRvZnBhZ2U9Im5vIiBkYXRhLXN0aWNreT0ibm8iIGRhdGEtc2xvdHRhcmdldGluZz0nJyBkYXRhLWRpc3BsYXlzbHVnPSJ5ZXMiIGRhdGEtc3RpY2t5LWR1cmF0aW9uPSI1IiBkYXRhLW5hbWU9IlRvcCI+PC9kaXY+HwBnZAIVD2QWAmYPZBYQZg9kFgRmD2QWDAIBDxYCHwBoFgQCAw9kFhACAQ8WAh8AaBYCAgEPDxYCHysFnQFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3NlY3VyZS9wYWdlcy9teWFjY291bnQuYXNweD9Db250ZXh0VXJsPSUyZmhlcCUyZmFic3RyYWN0JTJmMjAxNSUyZjAxMDAwJTJmc2VydW1faGVwYXRpdGlzX2JfdmlydXNfcm5hX2xldmVsc19hc19hbl9lYXJseS4xNC5hc3B4ZGQCAw8WAh8AaBYCAgEPDxYCHysFvgFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3NlY3VyZS9wYWdlcy9teWFjY291bnQuYXNweD9Db250ZXh0VXJsPSUyZmhlcCUyZmFic3RyYWN0JTJmMjAxNSUyZjAxMDAwJTJmc2VydW1faGVwYXRpdGlzX2JfdmlydXNfcm5hX2xldmVsc19hc19hbl9lYXJseS4xNC5hc3B4JmVkaXRXZWJQYXJ0PWVkaXRDaGFuZ2VQYXNzd29yZFdQZGQCBQ8WAh8AaBYCAgEPDxYCHysFnwFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3NlY3VyZS9wYWdlcy9teWZhdm9yaXRlcy5hc3B4P0NvbnRleHRVcmw9JTJmaGVwJTJmYWJzdHJhY3QlMmYyMDE1JTJmMDEwMDAlMmZzZXJ1bV9oZXBhdGl0aXNfYl92aXJ1c19ybmFfbGV2ZWxzX2FzX2FuX2Vhcmx5LjE0LmFzcHhkZAIHD2QWAgIBDw8WAh8rBbgBaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2hlcC9zZWN1cmUvcGFnZXMvbXlmYXZvcml0ZXMuYXNweD9Db250ZXh0VXJsPSUyZmhlcCUyZmFic3RyYWN0JTJmMjAxNSUyZjAxMDAwJTJmc2VydW1faGVwYXRpdGlzX2JfdmlydXNfcm5hX2xldmVsc19hc19hbl9lYXJseS4xNC5hc3B4JmNvbGxlY3Rpb249U2F2ZWRTZWFyY2hlc2RkAgsPZBYCAgEPDxYCHysFlQFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3BhZ2VzL3JlZ2lzdGVyLmFzcHg/Q29udGV4dFVybD0lMmZoZXAlMmZhYnN0cmFjdCUyZjIwMTUlMmYwMTAwMCUyZnNlcnVtX2hlcGF0aXRpc19iX3ZpcnVzX3JuYV9sZXZlbHNfYXNfYW5fZWFybHkuMTQuYXNweGRkAg0PZBYCAgEPFgIfAQUZaHR0cDovL2hlYWx0aGpvYnNwbHVzLmNvbWQCDw8WAh8AZxYCAgEPDxYGHysFsgFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3BhZ2VzL2xvZ2luLmFzcHg/Q29udGV4dFVybD0lMmZoZXAlMmZhYnN0cmFjdCUyZjIwMTUlMmYwMTAwMCUyZnNlcnVtX2hlcGF0aXRpc19iX3ZpcnVzX3JuYV9sZXZlbHNfYXNfYW5fZWFybHkuMTQuYXNweCZSZXF1ZXN0Rm9yPUFjdGl2YXRlU3Vic2NyaXB0aW9uHgdFbmFibGVkZx8AZ2RkAhMPFgIfAGgWAgIBDw8WAh8rBYkBaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2hlcC9fbGF5b3V0cy8xNS9vYWtzLmpvdXJuYWxzL2xvZ291dC5hc3B4P0NvbnRleHRVcmw9aHR0cHMlM2ElMmYlMmZqb3VybmFscy5sd3cuY29tJTJmaGVwJTJmcGFnZXMlMmZkZWZhdWx0LmFzcHhkZAIFDxYCHwBoFgICAQ8UKwACZGRkAgMPFgIfAGdkAgQPZBYCAgEPDxYIHyQFIHVzZXItbWVudV9fbGluayBqcy1yZWdpc3Rlci1saW5rHysFlQFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3BhZ2VzL3JlZ2lzdGVyLmFzcHg/Q29udGV4dFVybD0lMmZoZXAlMmZhYnN0cmFjdCUyZjIwMTUlMmYwMTAwMCUyZnNlcnVtX2hlcGF0aXRpc19iX3ZpcnVzX3JuYV9sZXZlbHNfYXNfYW5fZWFybHkuMTQuYXNweB8lAgIfAGcWAh8sBVR7ImV2ZW50TmFtZSI6IlJlZ2lzdGVyIiwiZXZlbnREZXRhaWwiOnsic291cmNlIjoiTWFzdGhlYWQgRHJvcGRvd24ifSwiaXNOdWxsIjpmYWxzZX1kAgUPFgIfAGcWAgIBDw8WAh8rBSBodHRwczovL3Nob3AubHd3LmNvbS9wLzAyNzAtOTEzOWRkAggPZBYCAgEPDxYEHwIFGEFBU0xEIE1lbWJlcj8gTG9naW4gaGVyZR8rBawBaHR0cHM6Ly9sb2dpbi5qb3VybmFscy5sd3cuY29tL09uZUlEL0xvZ2luLmFzcHg/UGFydG5lcklkcElkPWh0dHBzOi8vbXkuYWFzbGQub3JnJkxvZ2luX3R5cGU9U29jaWV0eVNzbyZyZXR1cm5Vcmw9aHR0cHMlM2ElMmYlMmZqb3VybmFscy5sd3cuY29tJTJmbHQlMmZwYWdlcyUyZmRlZmF1bHQuYXNweGRkAgsPZBYCAgYPZBYCAgEPZBYCAgUPDxYEHysFQGh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9oZXAvX2xheW91dHMvb2Frcy5qb3VybmFscy9wcml2YWN5LmFzcHgfAgUOUHJpdmFjeSBQb2xpY3lkZAIBD2QWBmYPEA8WBh4NRGF0YVRleHRGaWVsZAUEVGV4dB4ORGF0YVZhbHVlRmllbGQFBFRleHQfJmdkEBUGA0FsbAhBcnRpY2xlcwZJbWFnZXMGVmlkZW9zCFBvZGNhc3RzBUJsb2dzFQYDQWxsCEFydGljbGVzBkltYWdlcwZWaWRlb3MIUG9kY2FzdHMFQmxvZ3MUKwMGZ2dnZ2dnZGQCBQ8PFgIfKwU2aHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2hlcC9wYWdlcy9hZHZhbmNlZHNlYXJjaC5hc3B4ZGQCBg8PFgIfLmhkZAIBDw8WAh8rBSBodHRwczovL3Nob3AubHd3LmNvbS9wLzAyNzAtOTEzOWRkAgIPDxYCHysFlQFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3BhZ2VzL3JlZ2lzdGVyLmFzcHg/Q29udGV4dFVybD0lMmZoZXAlMmZhYnN0cmFjdCUyZjIwMTUlMmYwMTAwMCUyZnNlcnVtX2hlcGF0aXRpc19iX3ZpcnVzX3JuYV9sZXZlbHNfYXNfYW5fZWFybHkuMTQuYXNweGRkAgMPDxYEHysFnQFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3NlY3VyZS9wYWdlcy9teWFjY291bnQuYXNweD9Db250ZXh0VXJsPSUyZmhlcCUyZmFic3RyYWN0JTJmMjAxNSUyZjAxMDAwJTJmc2VydW1faGVwYXRpdGlzX2JfdmlydXNfcm5hX2xldmVsc19hc19hbl9lYXJseS4xNC5hc3B4HwBoZGQCBA8PFgIfAGgWAh8iBSJib3JkZXItcmlnaHQ6MXB4IHNvbGlkICFpbXBvcnRhbnQ7ZAIGDw8WAh8rBYkBaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2hlcC9fbGF5b3V0cy8xNS9vYWtzLmpvdXJuYWxzL2xvZ291dC5hc3B4P0NvbnRleHRVcmw9aHR0cHMlM2ElMmYlMmZqb3VybmFscy5sd3cuY29tJTJmaGVwJTJmcGFnZXMlMmZkZWZhdWx0LmFzcHgWAh8iBSJib3JkZXItcmlnaHQ6MXB4IHNvbGlkICFpbXBvcnRhbnQ7ZAIHDxYCHywFuQF7ImJyb3dzaW5nSGlzdG9yeSI6eyJpc0VuYWJsZWQiOnRydWUsInNlcnZpY2VVcmwiOiJodHRwczovL2FwaW0taGxycC1lanAtcHJvZC5henVyZS1hcGkubmV0L2VlIiwicGRmRG93bmxvYWRVcmwiOiIvX2xheW91dHMvMTUvb2Frcy5qb3VybmFscy9kb3dubG9hZHBkZi5hc3B4P3RyY2tuZ19zcmNfcGc9SGlzdG9yeVRhYiJ9fWQCCg9kFgZmDxAPFgYfLwUEVGV4dB8wBQRUZXh0HyZnZBAVBgNBbGwIQXJ0aWNsZXMGSW1hZ2VzBlZpZGVvcwhQb2RjYXN0cwVCbG9ncxUGA0FsbAhBcnRpY2xlcwZJbWFnZXMGVmlkZW9zCFBvZGNhc3RzBUJsb2dzFCsDBmdnZ2dnZ2RkAgUPDxYCHysFNmh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9oZXAvcGFnZXMvYWR2YW5jZWRzZWFyY2guYXNweGRkAgYPDxYCHy5oZGQCIQ9kFgJmD2QWHAIBD2QWAmYPZBYCZg9kFggCAQ8WAh8pBVBodHRwczovL2ltYWdlcy5qb3VybmFscy5sd3cuY29tL2hlcC9YTGFyZ2VUaHVtYi4wMTUxNTQ2Ny0yMDI1MDIwMDAtMDAwMDAuQ1YuanBlZ2QCAw8WAh8qBRNOZXZlciBNaXNzIGFuIElzc3VlZAIFDxYCHyoFQUdldCBuZXcgam91cm5hbCBUYWJsZXMgb2YgQ29udGVudHMgc2VudCByaWdodCB0byB5b3VyIGVtYWlsIGluYm94ZAIJDxYGHg9kYXRhLWFsZXJ0LXR5cGUFBEV0b2MeE2RhdGEtc3Vic2NyaWJlZC1tc2cFT1lvdSBhcmUgbm93IHN1YnNjcmliZWQgdG8gcmVjZWl2ZSBlVE9DIGFsZXJ0cyB3aGVuZXZlciBuZXcgaXNzdWVzIGFyZSBwdWJsaXNoZWQfKgUUR2V0IE5ldyBJc3N1ZSBBbGVydHNkAgMPZBYIAgEPFCsAAmRkZAIDD2QWAmYPDxYCHysFlQFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3BhZ2VzL3JlZ2lzdGVyLmFzcHg/Q29udGV4dFVybD0lMmZoZXAlMmZhYnN0cmFjdCUyZjIwMTUlMmYwMTAwMCUyZnNlcnVtX2hlcGF0aXRpc19iX3ZpcnVzX3JuYV9sZXZlbHNfYXNfYW5fZWFybHkuMTQuYXNweGRkAgUPFgIfAGcWAmYPDxYCHysFIGh0dHBzOi8vc2hvcC5sd3cuY29tL3AvMDI3MC05MTM5ZGQCCQ8WAh8AaBYCAgEPFCsAAmRkZAIFD2QWDgIBDxYCHwBoFgICAQ8UKwACZGRkAgMPZBYCZg8WAh8AaGQCBw8WBh8BBSBodHRwczovL3d3dy50ZmFmb3Jtcy5jb20vNDk2NjU3MB4GdGFyZ2V0BQZfYmxhbmsfKgUYU3VibWl0IGEgU2VydmljZSBSZXF1ZXN0ZAIJDxYCHwBoZAILDxYCHwBoZAIPDxQrAAIPFgQfJmcfJwICZGQWBGYPZBYCZg8VAR04MDAtNjM4LTMwMzAgKHdpdGhpbiB0aGUgVVNBKWQCAQ9kFgJmDxUBITMwMS0yMjMtMjMwMCAob3V0c2lkZSBvZiB0aGUgVVNBKWQCEQ8WAh8AZ2QCBw8WAh8sBaESeyJsb2dpbkNvbmZpZ3VyYXRpb24iOnsic2VydmljZVVybCI6Imh0dHBzOi8vc2VydmljZXMuam91cm5hbHMubHd3LmNvbS9JbnRlZ3JhdGlvblNlcnZpY2VzL0FjY291bnRTZXJ2aWNlLnN2Yy9Mb2dpbiIsInJlZ2lzdGVyVXJsIjoiaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2hlcC9wYWdlcy9yZWdpc3Rlci5hc3B4P0NvbnRleHRVcmw9JTJmaGVwJTJmYWJzdHJhY3QlMmYyMDE1JTJmMDEwMDAlMmZzZXJ1bV9oZXBhdGl0aXNfYl92aXJ1c19ybmFfbGV2ZWxzX2FzX2FuX2Vhcmx5LjE0LmFzcHgiLCJmb3Jnb3RQYXNzd29yZFVybCI6Imh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9oZXAvcGFnZXMvZm9yZ290cGFzc3dvcmQuYXNweD9Db250ZXh0VXJsPSUyZmhlcCUyZmFic3RyYWN0JTJmMjAxNSUyZjAxMDAwJTJmc2VydW1faGVwYXRpdGlzX2JfdmlydXNfcm5hX2xldmVsc19hc19hbl9lYXJseS4xNC5hc3B4IiwicmVkaXJlY3RVcmwiOiJodHRwczovL2pvdXJuYWxzLmx3dy5jb20vaGVwL3BhZ2VzL2xvZ2luLmFzcHg/Q29udGV4dFVybD0lMmZoZXAlMmZhYnN0cmFjdCUyZjIwMTUlMmYwMTAwMCUyZnNlcnVtX2hlcGF0aXRpc19iX3ZpcnVzX3JuYV9sZXZlbHNfYXNfYW5fZWFybHkuMTQuYXNweCIsInRva2VuS2V5IjoiQXBwU3NvVG9rZW4iLCJzc29Mb2dpbk9wdGlvbnMiOlt7ImxvZ2luSHJlZiI6Imh0dHBzOi8vbG9naW4uam91cm5hbHMubHd3LmNvbS9PbmVJRC9Mb2dpbi5hc3B4P1BhcnRuZXJJZHBJZD1odHRwczovL215LmFhc2xkLm9yZyZMb2dpbl90eXBlPVNvY2lldHlTc28mcmV0dXJuVXJsPWh0dHBzJTNhJTJmJTJmam91cm5hbHMubHd3LmNvbSUyZmhlcCUyZnBhZ2VzJTJmYXJ0aWNsZXZpZXdlci5hc3B4JTNmeWVhciUzZDIwMTUlMjZpc3N1ZSUzZDAxMDAwJTI2YXJ0aWNsZSUzZDAwMDE0JTI2dHlwZSUzZEFic3RyYWN0IiwiaW1hZ2VTcmMiOiIvYWFzbGRwdWJzL1B1Ymxpc2hpbmdJbWFnZXMvbG9nb3MvTG9nby5qcGciLCJsaW5rUHJlZml4VGV4dCI6IkFBU0xEIG1lbWJlcnMgbG9nIGluIGhlcmUiLCJsaW5rVGV4dCI6IkFBU0xEIG1lbWJlcnMgbG9nIGluIGhlcmUifV0sImN1c3RvbWVyU2VydmljZSI6eyJjdXN0b21lclNlcnZpY2VVU1Bob25lIjoiKDgwMCkgNjM4LTMwMzAiLCJjdXN0b21lclNlcnZpY2VJbnRlcm5hdGlvbmFsUGhvbmUiOiIzMDEtMjIzLTIzMDAiLCJjdXN0b21lclNlcnZpY2VFbWFpbCI6ImN1c3RvbWVyc2VydmljZUBsd3cuY29tIn0sInVzZUFsdGVybmF0aXZlQWNjb3VudExpbmtzIjpmYWxzZX0sImNvbW1vbkNvbmZpZ3VyYXRpb24iOnsiY29tbW9uRW5kcG9pbnRzIjp7ImFkZFRvRmF2b3JpdGVzU2VydmljZVVybCI6Imh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9oZXAvX2xheW91dHMvMTUvT0FLUy5Kb3VybmFscy9Vc2VyQ29sbGVjdGlvbnNTZXJ2aWNlLnN2Yy9BZGRUb0Zhd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{ return "ctl00_ctl29_g_66d092b4_9819_4479_a267_faf7b1636d3d_ctl00_emailToColleague"; }function image(id, nextImageId, previousImageId, title, description, rolloverUrl, popupUrl, fullSizeUrl, originalUrl, imageGalleryUrl, windowId){this.id = id;this.title = title;this.description = description;this.rolloverUrl = rolloverUrl;this.popupUrl = popupUrl;this.nextImageId = nextImageId;this.previousImageId = previousImageId; this.fullsizeUrl = fullSizeUrl; this.originalUrl = originalUrl;this.imageGalleryUrl = imageGalleryUrl; this.windowId=windowId}function Global_GetImagesCollection(){var images = new Object();images["hep27381-fig-0001"]=new image("hep27381-fig-0001","hep27381-fig-0002","","Figure 1","Scheme of the RACE‐based RT‐PCR technique used for quantitative analysis of two polyadenylated versions of HBV RNA (flRNA and trRNA). (A) HBV transcription <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">in vivo</em>. (B) Specific RT of polyadenylated HBV RNAs <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">in vitro</em> applying a primer with 3′‐end RNA corresponding sequence followed by oligo(dT) and an arbitrary anchored sequence, respectively. (C) Detection of generated cDNAs by target specific real‐time PCR using a HBV X gene‐specific primer and a fluorophore‐labeled TaqMan probe in combination with the arbitrary primer, respectively. Abbreviations: R, reporter; Q, quentcher.","https://images.journals.lww.com/hep/Rollover.01515467-201501000-00014.hep27381-fig-0001.jpeg","https://images.journals.lww.com/hep/Gallery.01515467-201501000-00014.hep27381-fig-0001.jpeg","https://journals.lww.com/hep/_layouts/oaks.journals/ImageView.aspx?k=hep:2015:01000:00014&i=hep27381-fig-0001&year=2015&issue=01000&article=00014&type=Abstract","https://images.journals.lww.com/hep/Original.01515467-201501000-00014.hep27381-fig-0001.jpeg","/hep/pages/imagegallery.aspx?year=2015&issue=01000&article=00014", "hep_2015_01000_00014_hep27381-fig-0001");images["hep27381-fig-0002"]=new image("hep27381-fig-0002","hep27381-fig-0003","hep27381-fig-0001","Figure 2","Box plots of the levels of HBV flRNA (A), HBV trRNA (B), HBV DNA (C), and HBsAg (D) during up to 24 months of treatment with either tenofovir or lamivudine. Boxes show 50% of observations around median, denoted by the black solid line in the box. Dots above the boxes represent values above the 50th percentile. The numbers of patients observed at each time point are given above the boxes. The median values lie close to the mean values given in Table 1. Abbreviation: BL, baseline.","https://images.journals.lww.com/hep/Rollover.01515467-201501000-00014.hep27381-fig-0002.jpeg","https://images.journals.lww.com/hep/Gallery.01515467-201501000-00014.hep27381-fig-0002.jpeg","https://journals.lww.com/hep/_layouts/oaks.journals/ImageView.aspx?k=hep:2015:01000:00014&i=hep27381-fig-0002&year=2015&issue=01000&article=00014&type=Abstract","https://images.journals.lww.com/hep/Original.01515467-201501000-00014.hep27381-fig-0002.jpeg","/hep/pages/imagegallery.aspx?year=2015&issue=01000&article=00014", "hep_2015_01000_00014_hep27381-fig-0002");images["hep27381-fig-0003"]=new image("hep27381-fig-0003","hep27381-fig-0004","hep27381-fig-0002","Figure 3","Heat map of the pair‐wise correlations among baseline characteristics. Fields in red and blue indicate positive and negative correlations between the characteristics. Numbers in the fields represent Pearson\'s correlation coefficients (<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">r</em>).","https://images.journals.lww.com/hep/Rollover.01515467-201501000-00014.hep27381-fig-0003.jpeg","https://images.journals.lww.com/hep/Gallery.01515467-201501000-00014.hep27381-fig-0003.jpeg","https://journals.lww.com/hep/_layouts/oaks.journals/ImageView.aspx?k=hep:2015:01000:00014&i=hep27381-fig-0003&year=2015&issue=01000&article=00014&type=Abstract","https://images.journals.lww.com/hep/Original.01515467-201501000-00014.hep27381-fig-0003.jpeg","/hep/pages/imagegallery.aspx?year=2015&issue=01000&article=00014", "hep_2015_01000_00014_hep27381-fig-0003");images["hep27381-fig-0004"]=new image("hep27381-fig-0004","hep27381-fig-0005","hep27381-fig-0003","Figure 4","Scatter plots showing levels of HBV trRNA (top) and flRNA (bottom) and corresponding levels of HBV DNA (both expressed in log<sub xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">10</sub> copies/mL) before antiviral treatment in 15 HBeAg‐positive patients achieving HBeAg seroconversion (A and B), in 35 HBeAg‐positive patients without subsequent HBeAg seroconversion (C and D), and in 12 HBeAg‐negative patients (E and F). r = Pearson\'s correlation coefficient; p = <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> value of the correlation <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">t</em> test.","https://images.journals.lww.com/hep/Rollover.01515467-201501000-00014.hep27381-fig-0004.jpeg","https://images.journals.lww.com/hep/Gallery.01515467-201501000-00014.hep27381-fig-0004.jpeg","https://journals.lww.com/hep/_layouts/oaks.journals/ImageView.aspx?k=hep:2015:01000:00014&i=hep27381-fig-0004&year=2015&issue=01000&article=00014&type=Abstract","https://images.journals.lww.com/hep/Original.01515467-201501000-00014.hep27381-fig-0004.jpeg","/hep/pages/imagegallery.aspx?year=2015&issue=01000&article=00014", "hep_2015_01000_00014_hep27381-fig-0004");images["hep27381-fig-0005"]=new image("hep27381-fig-0005","hep27381-fig-0006","hep27381-fig-0004","Figure 5","Scatter plots showing levels of HBV trRNA (top) and flRNA (bottom; both in log<sub xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">10</sub> copies/mL) and corresponding levels of HBsAg (log<sub xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">10</sub> IU/mL) before antiviral treatment in 15 HBeAg‐positive patients achieving HBeAg seroconversion (A and B), in 35 HBeAg‐positive patients without subsequent HBeAg seroconversion (C and D), and in 12 HBeAg‐negative patients (E and F). r = Pearson\'s correlation coefficient; p = <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">P</em> value of the correlation <em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">t</em> test.","https://images.journals.lww.com/hep/Rollover.01515467-201501000-00014.hep27381-fig-0005.jpeg","https://images.journals.lww.com/hep/Gallery.01515467-201501000-00014.hep27381-fig-0005.jpeg","https://journals.lww.com/hep/_layouts/oaks.journals/ImageView.aspx?k=hep:2015:01000:00014&i=hep27381-fig-0005&year=2015&issue=01000&article=00014&type=Abstract","https://images.journals.lww.com/hep/Original.01515467-201501000-00014.hep27381-fig-0005.jpeg","/hep/pages/imagegallery.aspx?year=2015&issue=01000&article=00014", "hep_2015_01000_00014_hep27381-fig-0005");images["hep27381-fig-0006"]=new image("hep27381-fig-0006","hep27381-fig-0007","hep27381-fig-0005","Figure 6","Regression coefficients of all factors in the Elastic Net model versus regularization parameter lambda for (A) HBV flRNA and (B) HBV trRNA. Each colored curve represents a regression coefficient corresponding to the factors tested for association with HBeAg seroconversion. The graph shows how the factors are included in the model (become nonzero) as lambda changes. The smaller the lambda is when a factor becomes nonzero the higher its association with HBeAg seroconversion. The shrinkage parameter of the model alpha was 0.5.","https://images.journals.lww.com/hep/Rollover.01515467-201501000-00014.hep27381-fig-0006.jpeg","https://images.journals.lww.com/hep/Gallery.01515467-201501000-00014.hep27381-fig-0006.jpeg","https://journals.lww.com/hep/_layouts/oaks.journals/ImageView.aspx?k=hep:2015:01000:00014&i=hep27381-fig-0006&year=2015&issue=01000&article=00014&type=Abstract","https://images.journals.lww.com/hep/Original.01515467-201501000-00014.hep27381-fig-0006.jpeg","/hep/pages/imagegallery.aspx?year=2015&issue=01000&article=00014", "hep_2015_01000_00014_hep27381-fig-0006");images["hep27381-fig-0007"]=new image("hep27381-fig-0007","","hep27381-fig-0006","Figure 7","ROC curves describing the performance of the prediction of the linear model to classify patients achieving HBeAg seroconversion by levels of HBV flRNA and trRNA, HBV DNA, and HBsAg at baseline (A) and by declines in these markers at month 3 (B) and month 6 (C) of treatment with polymerase inhibitors. 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hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors', '11252014', 'Florian van B\u00F6mmel, Anne Bartens, Alena Mysickova, et al', '61', '1', '\u00A9 2014 by the American Association for the Study of Liver Diseases', '01515467-201501000-00014', '', false, ''); } </script> <div id="ArticleContainer"> <article id="ej-abstract-view" xmlns:ssr="http://ssr-eus-go-csi.cloudapp.net/v1/assets" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xhtml="http://www.w3.org/1999/xhtml"><section class="ejp-r-article-subsection"><div class="ejp-r-article-subsection__text">Viral Hepatitis</div></section><header class="ejp-article-header"><h1 class="ejp-article-title">Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors</h1></header><section id="ejp-article-authors"><p id="P7">van Bömmel, Florian<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">1,†</sup>; Bartens, Anne<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">1,2,†</sup>; Mysickova, Alena<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">3</sup>; Hofmann, Jörg<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">2</sup>; Krüger, Detlev H.<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">2</sup>; Berg, Thomas<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">*,1</sup>; Edelmann, Anke<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">2</sup></p><section><a href="#" id="ejp-article-authors-link"> Author Information <i class="wk-icon-arrow-down-r"></i></a></section></section><section id="ejp-article-authors-info" class="ejp-article-authors-info ejp-article-authors-info--hidden"><div class="ejp-article-authors-info-holder"> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">1</sup>Clinic for Hepatology and Rheumatology, Hepatology SectionUniversity Hospital LeipzigLeipzigGermany</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">2</sup>Institute of Medical Virology, Helmut‐Ruska‐HausCharité‐University Hospital BerlinBerlinGermany</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">3</sup>Max Planck Institute for Molecular GeneticsBerlinGermany</p> <p id="correspondenceTo"><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">*</sup>Address reprint requests to: Thomas Berg, M.D., Clinic for Gastroenterology and Rheumatology, Hepatology Section, University Clinic Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany. E‐mail: <span><a href="/cdn-cgi/l/email-protection#305d51595c445f0a44585f5d51431e52554257705d5554594a595e1e455e591d5c5559404a59571e5455" onclick="javascript:window.open('mailto:mailto:thomas.berg@medizin.uni-leipzig.de');return false"><span class="__cf_email__" data-cfemail="e99d818684889ac78b8c9b8ea9848c8d80938087c79c8780c4858c809993808ec78d8c">[email protected]</span></a></span>; fax: +49 341 9712330.</p> <p id="hep27381-note-0001"><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">†</sup>These authors contributed equally.</p> </div></section><section id="article-journal-info"><div class="ej-journal-info"><span class="ej-journal-name">Hepatology </span><span id="ej-journal-date-volume-issue-pg"><a href="/hep/toc/2015/01000">61(1):p 66-76, January 2015.</a></span><span> | </span><span class="ej-journal-doi">DOI: </span>10.1002/hep.27381</div></section><section id="ejp-article-indicators" class="ejp-article-indicators"><ul class="ejp-article-indicators__list"> <li id="ej-article-indicators-buy" class="ejp-article-indicators__list-item" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()"><a href="#ContentAccessOptions"><span class="ejp-indicator">Buy</span></a></li> <li id="ej-article-indicators-erratum" class="ejp-article-indicators__list-item" onmouseover="javascript:Tooltip_Erratum()" onmouseout="javascript:Tooltip_MouseOut()"><a class="ejp-indicator" href="#errata">Erratum</a></li> </ul><button id="openArticleMetricsPopupButton" type="button" class="wk-button wk-button-ghost wk-button-icon-left ejp-article-metrics-btn" data-articleMetricsEndpoint="//services.journals.lww.com/IntegrationServices/ArticleMetricsService.svc" data-articleMetricsDetailsUrl="https://wolterskluwer.altmetric.com/details/" data-doi="10.1002/hep.27381" data-suiteId="vrs_woltere_journalsglobalvrs" data-articlePublicationDate="2014-11-25" data-articlePublicationDateString="November 25, 2014" data-receivedDate="2014-02-17" data-revisionReceivedDate="" data-acceptedDate="2014-08-15" data-crossrefRefLinkRoot="https://doi.org/" data-medlineRefLinkRoot="http://www.ncbi.nlm.nih.gov/pubmed/" data-pubMedId="25132147"><i class="wk-icon-filled-chart-r"></i><i class="wk-icon-filled-chart-white-r"></i> Metrics </button></section><section class="ejp-article-tabs" id="abstractWrap"><h2 class="ejp-article-tabs-heading">Abstract</h2> <div class="ejp-article-tabs__tabpanel" id="panel1" role="tabpanel" aria-labelledby="tab1"> <div id="article-abstract-content1"> <div class="ejp-article-text-abstract"> <p>Hepatitis B envelope antigen (HBeAg) seroconversion represents an endpoint of treatment of chronic hepatitis B virus (HBV) infections. We have studied whether levels of serum HBV RNA during polymerase inhibitor treatment might be helpful for predicting HBeAg seroconversion. HBV RNA levels were determined in serial serum samples from 62 patients with chronic HBV infection (50 HBeAg positive). Patients received antiviral treatment for a mean duration of 30 ± 15 (range, 4‐64) months. A new rapid amplification of complimentary DNA‐ends‐based real‐time polymerase chain reaction was established for quantitative analysis of polyadenylated full‐length (fl) and truncated (tr) HBV RNA. HBV RNA, HBV DNA, and hepatitis B surface antigen (HBsAg) levels as well as presence of HBeAg and hepatitis B envelope antibody were measured at baseline, month 3, month 6, and subsequent time points. Fifteen patients who achieved HBeAg seroconversion after a mean duration of 19 ± 14 (range, 3‐56) months of antiviral treatment showed a significantly stronger decline in mean HBV flRNA and trRNA levels from baseline to month 3 of 1.0 ± 1.4 (range, −1.6‐3.4) and 2.1 ± 1.4 (range, 0‐3.9) and to month 6 of 1.8 ± 1.4 (range, 0‐4.6) and 3.1 ± 1.7 (range, 0‐5.1) log<sub xmlns:mrws="http://webservices.ovid.com/mrws/1.0">10</sub> copies/mL, respectively, in comparison to 35 HBeAg‐positive patients without HBeAg seroconversion (<em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">P</em> < 0.001 for months 3 and 6). A similar decline in HBV RNA levels was observed in HBeAg‐negative patients. The decline of HBV RNA levels at months 3 and 6 of treatment was to be the strongest predictor of HBeAg seroconversion, when compared to levels of HBV DNA, HBsAg, alanine aminotransferase, and HBV genotype, age, and sex. <em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">Conclusion</em>: Serum HBV RNA levels may serve as a novel tool for prediction of serological response during polymerase inhibitor treatment in HBeAg‐positive patients. (H<span style="font-variant: small-caps;" xmlns:mrws="http://webservices.ovid.com/mrws/1.0">epatology</span> 2015;61:66–76)</p> </div> </div> </div></section><div class="ejp-r-article-erratum"> <div class="ejp-r-article-erratum__header"><span class="wk-icon-info-r ejp-r-article-erratum__header-icon"></span><strong class="ejp-r-article-erratum__header-title"> Erratum </strong></div> <div class="ejp-r-article-erratum__body"> <p id="JCL-P-0">In the January 2015 issue of H<span style="font-variant: small-caps;" xmlns:mrws="http://webservices.ovid.com/mrws/1.0">epatology</span>, in the article titled “Serum Hepatitis B Virus RNA Levels as an Early Predictor of Hepatitis B Envelope Antigen Seroconversion During Treatment With Polymerase Inhibitors” (volume 61, pages 66‐76; doi: 10.1002/hep.27381), by Florian van Bömmel, Anne Bartens, Alena Mysickova, Jörg Hofmann, Detlev H. Krüger, Thomas Berg, and Anke Edelmann, the phrase “hepatitis B envelope antigen,” in the text and in the title, should have read “hepatitis B e antigen.”</p> <p id="JCL-P-1">In addition, in Table 1, “HBV flRNA” and “HBV trRNA” should have been followed by the symbol † instead of *.</p> <p id="JCL-P-2">We apologize for these errors.</p> <p><a href="https://journals.lww.com/hep/fulltext/2016/01000/serum_hepatitis_b_virus_rna_levels_as_an_early.49.aspx" class="ejp-r-article-erratum__body-reference">Hepatology. 63(1):349, January 2016. </a></p> </div> </div><section class="ej-article-copyright">© 2014 by the American Association for the Study of Liver Diseases</section></article> </div> </div> <section id="ContentAccessOptions" class="article-not-authorized-msg"> <div class="ejp-access-options-wrapper"> <div class="ejp-access-options ejp-access-options--desktop"> <div id="ctl00_ctl29_g_66d092b4_9819_4479_a267_faf7b1636d3d_ctl00_FullTextAccessOptionsContainer" 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