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}) })(jQuery); </script> </head> <body class="post-template-default single single-post postid-201 single-format-standard header-image full-width-content genesis-breadcrumbs-visible"><div class="site-container"><header class="site-header"><div class="wrap"><div class="title-area"><p class="site-title"><a href="https://www.thermofisher.com/" title="Thermo Fisher Scientific">Thermo Fisher Scientific</a></p><p class="site-description">Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology</p></div><div class="widget-area header-widget-area"><section id="block-5" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> <section id="block-6" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> </div><div class="breadcrumb"><span class="breadcrumb-link-wrap"><a href="https://www.thermofisher.com/blog/?">Accelerating Science</a></span><span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/"><span class="breadcrumb-link-text-wrap">Life in Atomic Resolution</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/cryo-electron-microscopy-cryo-em/"><span class="breadcrumb-link-text-wrap">Cryo-Electron Microscopy (Cryo-EM)</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">Cryo-EM Gives Researchers a Detailed View of the Zika Virus Structure</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-201 post type-post status-publish format-standard has-post-thumbnail category-cryo-electron-microscopy-cryo-em category-unlocking-the-mysteries-with-cryo-em tag-cryo-electron-microscopy tag-cryo-em tag-electron-microscopy tag-fei tag-human-test-phase tag-purdue-university tag-thermo-fisher-scientific tag-thermo-scientific tag-unlocking-the-mysteries tag-vaccine tag-vaccines tag-virus tag-zika entry" aria-label="Cryo-EM Gives Researchers a Detailed View of the Zika Virus Structure"><header class="entry-header"><h1 class="entry-title">Cryo-EM Gives Researchers a Detailed View of the Zika Virus Structure</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/author/gabriellakiss/" title="Posts by Gabriella Kiss" rel="author">Gabriella Kiss</a> </span> <span class="post-info-date"> 02.04.2019 </span> </header><div class="entry-content"><p>Outbreaks of the Zika virus disease in 2015 and 2016 sparked back-to-back global health crises, infecting millions of people, leaving thousands of children with serious birth defects, and leading to neurological problems and internal bleeding in some adults.</p> <p>Zika virus belongs to the family of flaviviruses that are transmitted by mosquitos and ticks. Pregnant women can also transfer the Zika virus to their unborn babies, who often develop microcephaly (which results in abnormally small heads and sometimes smaller brains) or severe brain damage. There are currently no specific drugs to help prevent or treat Zika infections.</p> <p><img decoding="async" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/04/rossmann-zika-1-3.jpg" /></p> <p><em>Cryo-EM structure of mature Zika virus at 3.1脜 resolution. The three envelope glycoproteins are colored yellow, blue and red. (Purdue University photo/Madhumati Sevvana)</em></p> <h2><strong>How cryo-EM is helping scientists understand the Zika virus</strong></h2> <p>In 2016, scientists worldwide were searching desperately for a way to control the rapidly spreading virus. At that time, <a href="https://ter.li/qmb2q1">a team of researchers at Purdue University</a> were the first to discover the structure of the Zika virus, a key step to seeing how a protein interacts with other compounds in the body.</p> <p><a href="https://ter.li/tdjsce">Using cryo-EM</a>, the team captured an image of the virus at a resolution of 3.8 脜. Two years later, the same team achieved an even higher resolution of 3.1 脜, and combined thousands of 2D images to construct a 3D model of the virus鈥檚 structure.</p> <p><em>Purdue University researchers Michael Rossmann and Richard Kuhn have <a href="https://ter.li/4t4exb">been at the forefront of discovery</a> with the help of a technology that led to a Nobel Prize in chemistry for three scientists. Via Purdue University.</em></p> <p>At lower resolutions, many flaviviruses appear virtually identical. The high-resolution images that scientists captured with cryo-EM enabled them to see the landscape of the Zika virus and compare its protein interactions with those of other flaviviruses. With such a detailed view of the structure, researchers were also able to identify probable drug-binding pockets, helping scientists design vaccines and anti-viral compounds that inhibit the Zika virus. Thanks, in part, to cryo-EM for solving the structure of the virus, at least two of these vaccines are <a href="https://ter.li/zztn6l">now at the human test phase</a>.</p> <p>With the ability to examine structures at near atomic level, cryo-EM is helping scientists get a clearer picture of the underlying structure of the Zika virus and many other diseases. This knowledge helps researchers accelerating the development of critical vaccines that lead to the prevention of these diseases</p> <p><a href="https://www.thermofisher.com/blog/microscopy/two-electron-microscopy-methods-identify-targets-for-future-malaria-drug-design/?cid=blog-zika-ctaimage"><img decoding="async" class="aligncenter size-full wp-image-553" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/04/malaria-1.jpg" alt="malaria" width="703" height="372" /></a></p> <p><a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.thermofisher.com%2Fblog%2Fmicroscopy%2F%3Fcid%3Dblog-conclusion&data=02%7C01%7C%7C29aacc2aba0247dfe47508d66057dc4d%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C636802327799069889&sdata=WqypQznM8gBsqeX7XzAaTbfTamBT2JrAifT%2Bf1yzHGs%3D&reserved=0">Subscribe now</a><em> to receive new Accelerating Microscopy posts straight to your inbox.</em></p> <p><em>Gabriella Kiss, PhD, is a Product Marketing Manager for Single Particle Workflow at Thermo Fisher Scientific.</em></p> <p>To learn more about cryo-EM, <a href="https://ter.li/6wlien">fill out this form</a> to speak with an expert.</p>  <div class="jp-relatedposts"> <div class="related-post related-1"> <a href="https://www.thermofisher.com/blog/atomic-resolution/what-is-cryo-em-what-is-cryo-electron-microscopy/"><img width="310" height="274" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2024/10/cryoEM-blog-virus-pore4-1920x600_Header-310x274.jpg" class="attachment-grid size-grid wp-post-image" alt="cryoEM-blog-virus pore" decoding="async" /></a> <span class="grid-content"> <h4 class="entry-title"><a href="https://www.thermofisher.com/blog/atomic-resolution/what-is-cryo-em-what-is-cryo-electron-microscopy/">What is cryo-EM?</a></h4> <p>Cryo-EM: cryo electron microscopy Cryo-electron microscopy (... </p> <a 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