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id="main" class="site-main" role="main"> <article id="post-5030" class="post-5030 post type-post status-publish format-standard hentry category-general"> <div id="breadcrumb"> <div id="crumbs"><span class="crumb"><a href="https://www.compbio.com">Home</a></span> <i class="fa fa-angle-right"></i> <span class="crumb"><a href="https://www.compbio.comgeneral/">General</a></span> <i class="fa fa-angle-right"></i> <span class="current">Carotid Artery Repair</span></div> </div> <div class="entry-content"> <div class="the-content-contain"> <div class="row builder-row content-row"> <div class="medium-12 columns"> <h2><img class="wp-image-5036 alignleft" src="https://www.compbio.com/images/CBI-carotid-artery-image.jpg?v=1712248149" alt="" width="934" height="445" srcset="https://www.compbio.com/images/CBI-carotid-artery-image.jpg?v=1712248149 1698w, https://www.compbio.com/images/CBI-carotid-artery-image-300x143.jpg?v=1712248373 300w, https://www.compbio.com/images/CBI-carotid-artery-image-1024x488.jpg?v=1712248364 1024w, https://www.compbio.com/images/CBI-carotid-artery-image-768x366.jpg?v=1712248355 768w, https://www.compbio.com/images/CBI-carotid-artery-image-1536x732.jpg?v=1712248345 1536w" sizes="(max-width: 934px) 100vw, 934px" /></h2> <p> </p> <h2></h2> <h2></h2> <h2></h2> <h2></h2> <h2></h2> <h2></h2> <h2></h2> <h2></h2> <h2><strong>Atherosclerosis of the Carotid Artery</strong></h2> <p>Treatment for severe <strong>carotid</strong> stenosis involves eliminating the <strong>artery</strong> blockage. The most common way to do that is with a surgery called “<strong>carotid</strong> endarterectomy.” This is performed by making an incision along the front of the neck, opening the <strong>carotid artery</strong> and removing the plaque. This procedure is done to restore normal blood flow to the neck and brain to prevent a stroke. <a href="https://www.youtube.com/watch?v=UF5mblbv8iE"><em><strong><span style="color: #008080;">Click here to see a video of one of our carotid artery procedures.</span></strong></em></a></p> <p><strong>What is atherosclerosis</strong></p> <p>The carotid arteries are large blood vessels on each side of the neck that carry fresh oxygenated blood to the brain (<strong>internal carotid artery</strong>) and the face (<strong>external carotid artery</strong>). The carotid arteries may become diseased with atherosclerosis, resulting in plaque that narrows the lumen of the artery, causing carotid artery stenosis. Risk factors in humans for carotid artery stenosis include age, smoking, diabetes, high cholesterol, and high blood pressure. This is a major cause of <strong>Stroke</strong>.</p> <p><strong>Induction of neointimal hyperplasia and assessment of test drugs</strong></p> <p>At CBI, we offer an optimized and validated surgically-induced model of carotid artery neointimal hyperplasia in rats. This model is considered to be the gold standard the disease in man. For this model, a restenosis injury is induced using a small Foley Balloon Catheter that is introduced into the carotid artery. The catheter denudes the artery internal lining and over the following 2 weeks, pronounced neointimal hyperplasia develops. The lesion is consistent with the disease in human patients. Various test and control articles may be administered and their effects on the lesion characterized and measured. At the end of the study, the arteries are collected and the neointimal hyperplasia is measured and evaluated histopathologically and morphometrically. Immunohistochemistry and biochemical markers may also be employed.</p> <h4><b>Overall Goal</b></h4> <p>Reducing or improving the lesions so the blood can flow freely and not get clotted up and cause a stroke.</p> <p><img loading="lazy" class="wp-image-5045 alignleft" src="https://www.compbio.com/images/CBI-carotid-web-images.jpg?v=1712249933" alt="" width="403" height="336" srcset="https://www.compbio.com/images/CBI-carotid-web-images.jpg?v=1712249933 1374w, https://www.compbio.com/images/CBI-carotid-web-images-300x250.jpg?v=1712249966 300w, https://www.compbio.com/images/CBI-carotid-web-images-1024x854.jpg?v=1712249984 1024w, https://www.compbio.com/images/CBI-carotid-web-images-768x641.jpg?v=1712249999 768w" sizes="(max-width: 403px) 100vw, 403px" /></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p><a href="https://www.youtube.com/watch?v=UF5mblbv8iE"><strong>Click here to see a video of one of our carotid artery procedures.</strong></a></p> <p><a href="https://www.youtube.com/watch?v=UF5mblbv8iE"><img loading="lazy" class="wp-image-5088 alignleft" src="https://www.compbio.com/images/CBI-website-images-mouse-youtube-scaled.jpg?v=1712250221" alt="" width="177" height="159" srcset="https://www.compbio.com/images/CBI-website-images-mouse-youtube-scaled.jpg?v=1712250221 2560w, https://www.compbio.com/images/CBI-website-images-mouse-youtube-300x270.jpg?v=1712250245 300w, https://www.compbio.com/images/CBI-website-images-mouse-youtube-1024x922.jpg?v=1712250258 1024w, https://www.compbio.com/images/CBI-website-images-mouse-youtube-768x691.jpg?v=1712250273 768w, https://www.compbio.com/images/CBI-website-images-mouse-youtube-1536x1383.jpg?v=1712250287 1536w, https://www.compbio.com/images/CBI-website-images-mouse-youtube-2048x1843.jpg?v=1712250300 2048w" sizes="(max-width: 177px) 100vw, 177px" /></a></p> <p> </p> <p> </p> <p> </p> <p> </p> <p><strong><span style="color: #008080;">– Contact Comparative Biosciences, Inc. to discuss a scientific study program for Carotid Endarterectomy Studies and Services.</span></strong></p> <h4><strong>Contact Jonathan A. Geller, MS</strong><br /> <em><strong>Business Development Manager</strong></em></h4> <h4><em><strong>888-994-4870</strong></em></h4> <p> </p> <p><a href="https://www.youtube.com/watch?v=UF5mblbv8iE"><img loading="lazy" class="wp-image-5138 alignleft" src="https://www.compbio.com/images/Screen-Shot-2021-01-11-at-3.05.40-PM.png?v=1712250533" alt="" width="327" height="317" srcset="https://www.compbio.com/images/Screen-Shot-2021-01-11-at-3.05.40-PM.png?v=1712250533 1980w, https://www.compbio.com/images/Screen-Shot-2021-01-11-at-3.05.40-PM-300x291.png?v=1712250557 300w, https://www.compbio.com/images/Screen-Shot-2021-01-11-at-3.05.40-PM-1024x993.png?v=1712250588 1024w, https://www.compbio.com/images/Screen-Shot-2021-01-11-at-3.05.40-PM-768x745.png?v=1712250603 768w, https://www.compbio.com/images/Screen-Shot-2021-01-11-at-3.05.40-PM-1536x1489.png?v=1712250616 1536w" sizes="(max-width: 327px) 100vw, 327px" /></a></p> <p> </p> </div> </div> </div> </div> </article> </main> </div> </div> <div class="call-out"> <h3 class="content-left"><span class="line-one">Have a question</span> <span class="line-two">or need a quote?</span></h3> <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 100 85" style="enable-background:new 0 0 100 85;" xml:space="preserve"> <style type="text/css"> .st0{fill:#FFFFFF;} </style> <g> <path class="st0" d="M64.3,0.5H16c-8.8,0-16,7.2-16,16V44c0,8.4,6.6,15.4,14.9,16l-3.7,17.4L31.6,60h8.8V43.9 c0-8.7,7.1-15.8,15.8-15.8h24.2V16.5C80.3,7.7,73.1,0.5,64.3,0.5z"/> <path class="st0" d="M89.1,33h-33c-6,0-10.9,4.9-10.9,10.9v18.8c0,6,4.9,10.9,10.9,10.9h22.4l13.9,11.8l-2.5-11.9 c5.7-0.4,10.2-5.1,10.2-10.9V44C100,38,95.1,33,89.1,33z M85.5,49.3c2.2,0,4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1s-4-1.8-4-4.1 C81.5,51.1,83.3,49.3,85.5,49.3z M59.6,57.4c-2.2,0-4-1.8-4-4.1c0-2.2,1.8-4.1,4-4.1c2.2,0,4,1.8,4,4.1 C63.7,55.6,61.9,57.4,59.6,57.4z M68.5,53.4c0-2.2,1.8-4.1,4-4.1s4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1S68.5,55.6,68.5,53.4z"/> </g> </svg> <h3 class="content-right"><span>We can help!</span> <a href="https://www.compbio.com/contact-us/"><span class="cta-btn">Contact us</span></a></h3> </div> </div> </div> <footer id="colophon" class="site-footer row"> <div class="site-info medium-12 columns"> Comparative Biosciences, Inc. · <strong>Phone: 888-994-4879</strong><br> Copyright 2024 Comparative Biosciences, Inc. 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