CINXE.COM

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class="region region-content"> <section id="block-system-main" class="block block-system clearfix"> <div id="content" class="col-xs-12 col-sm-8 col-md-9 col-lg-9 col-xl-9"><div id="content_column"> <h1>BI 3231 <span class="new-logo" title="New Product">New</span> </h1> <div class="product_meta"> <span class="category_number highlight left">Cat. No. 8039</span> <span class="submit_review left"><a href="/reviews/8039" rel="nofollow" class="btn btn-quaternary">Submit a Review</a></span> <span class="datasheet_link right"><a href="#ds_datasheets" class="scroll_to">Datasheet / COA / SDS</a></span> </div> <div class="product_wrapper"> <div class="product_ordering"> <form action="/products/bi-3231_8039" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block"> <table class="add_to_cart"> <thead> <tr> <th class="ds_size_price_column">Pricing</th> <th class="ds_availability_column">Availability</th> <th class="ds_delivery_column"> </th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="8039/5"> <td class="et_atc_results" colspan="3"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-80392f5 form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-80392f5" name="catnum-8039%2F5" value="" size="5" maxlength="3" /></div></td> </tr> </tbody> </table> <div class="ds_atc_pre_buttons"></div> <div class="ds_atc_buttons"> <button class="btn atc_print_quote_btn atc_hidden pull-left btn-default form-submit" style="display: none;" title="Enter quantities above and click to create a quote" type="submit" id="edit-print-quote" name="print_quote_btn" value="Print Quote">Print Quote</button> <a href="/support/bulk-quantities-form?catnum=8039" class="btn btn-secondary atc_hidden bulk_btn" style="display:none;" rel="nofollow" title="Competitive discounts on products purchased in bulk quantities">Bulk Orders</a> <button class="btn btn-primary atc_hidden atc_btn form-submit icon-before" style="display:none;" title="Enter quantities above and click to add to cart" type="submit" id="edit-add-to-cart" name="add_to_cart_btn" value="Add to Cart"><span class="icon glyphicon glyphicon-plus" aria-hidden="true"></span> Add to Cart</button> </div> <div class="ds_atc_post_buttons"></div> </div> <a href="/quote/instruments/ella-automated-immunoassay-system" class="btn btn-secondary atc_request_quote_simple_plex_assay" style="display:none" rel="nofollow">Request a Quote</a><input type="hidden" name="form_build_id" value="form-1l4BMaxOWZ-LOZ1hPtL_5LM9bdKWkwsKdgcrhmx9duI" /> <input type="hidden" name="form_id" value="atc_datasheet_form" /> </div></form> </div> <div class="product_image_wrapper"> <div class="product_image tocris_product_image">  <div id="tocris_product_images" class="carousel slide" data-ride="carousel">  <div class="carousel-inner" role="listbox"> <div class="item active"> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" onClick="event.preventDefault();" data-title="Cat. No. 8039 - BI 3231" href="https://resources.tocris.com/images/datasheets/structures/bi-3231_8039.png"> <img src="https://resources.tocris.com/images/datasheets/structures/bi-3231_8039.png" class="img-fluid" alt="Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor" title="Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor"> </a> </div> </div> </div> </div> </div> </div> <div class="product_info_wrapper"> <div class="product_info"> <span class="highlight">Description:</span> Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor </div> <div class="product_info"> <span class="highlight">Chemical Name:</span> 1-[[5-(2,4-Difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl-2,4(1<em>H</em>,3<em>H</em>)pyrimidinedione </div> <div class="product_info"> <span class="highlight">Purity:</span> ≥98% (HPLC) </div> </div> </div> <div class="tabbed_content"><div class="tab_menu"><div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details"><span>Datasheet</span></div><div class="tab tab_2" data-tab="2" data-tabname="product-citations"><span>Citations</span></div><div class="tab tab_3" data-tab="3" data-tabname="product-reviews"><span>Reviews</span></div><div class="tab tab_4" data-tab="4" data-tabname="product-literature"><span>Literature (2)</span></div></div><div class="tab_content tab_1 tab_open" data-tab="1"><a id="product-details"></a><div> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to" href="#ds_biological_activity">Biological Activity</a> <a class="btn btn-quaternary scroll_to" href="#ds_technical_data">Technical Data</a> <a class="btn btn-quaternary scroll_to" href="#ds_solubility">Solubility</a> <a class="btn btn-quaternary scroll_to" href="#ds_stock_solutions">Calculators</a> <a class="btn btn-quaternary scroll_to" href="#ds_datasheets">Datasheets</a> <a class="btn btn-quaternary scroll_to" href="#ds_reference_data">References</a> </div> <div id="ds_biological_activity" class="datasheet_section"> <h2>Biological Activity for BI 3231</h2> <p>BI 3231 is a potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor (IC<sub>50</sub> values are 1 nM and 13 nM at hHSD17B13 and mHSD17B13 respectively; K<sub>i</sub> = 0.7 nM). Reduces palmitic acid-induced toxicity in hepatocytes. Suitable for use <em>in vivo</em> and <em>in vitro</em>.</p> </div> <div class="datasheet_section"> <h2>Licensing Information</h2> <p>This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the <a href='https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI-3231' class='a___link-external' target='_blank'>BI 3231 probe summary</a> on the SGC website.</p> </div> <div id="ds_technical_data" class="datasheet_section"> <h2>Technical Data for BI 3231</h2> <table class="technical_data_table"> <tr> <td class="tdt_name"> M. Wt </td> <td class="tdt_data"> 380.37 </td> </tr> <tr> <td class="tdt_name"> Formula </td> <td class="tdt_data"> C<sub>16</sub>H<sub>14</sub>F<sub>2</sub>N<sub>4</sub>O<sub>3</sub>S </td> </tr> <tr> <td class="tdt_name"> Storage </td> <td class="tdt_data"> Store at -20°C </td> </tr> <tr> <td class="tdt_name"> Purity </td> <td class="tdt_data"> ≥98% (HPLC) </td> </tr> <tr> <td class="tdt_name"> CAS Number </td> <td class="tdt_data"> 2894848-07-6 </td> </tr> <tr> <td class="tdt_name"> PubChem ID </td> <td class="tdt_data"> 167312378 </td> </tr> <tr> <td class="tdt_name"> InChI Key </td> <td class="tdt_data"> XKDHFIPNTTUSIA-UHFFFAOYSA-N </td> </tr> <tr> <td class="tdt_name"> Smiles </td> <td class="tdt_data"> O=C1C(C)=CN(CC2=NN=C(C3=C(F)C(O)=C(F)C=C3)S2)C(N1CC)=O </td> </tr> </table> <p class="small">The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.</p> <p class="small">Tocris products are intended for laboratory research use only, unless stated otherwise.</p> </div> <div id="ds_solubility" class="datasheet_section"> <h2>Solubility Data for BI 3231</h2> <table class="table table-bordered" id="ds_solubility_tbl"> <tr> <th></th> <th>Solvent</th> <th>Max Conc. mg/mL</th> <th>Max Conc. mM</th> </tr> <tr> <th class="solubility_text" rowspan="2">Solubility</th> </tr> <tr> <td>DMSO</td> <td>3.8</td> <td>10 with gentle warming</td> </tr> </table> </div>  <div id="ds_stock_solutions" class="datasheet_section"> <h2>Preparing Stock Solutions for BI 3231</h2> <p> The following data is based on the <span id="ss_type">product</span> molecular weight <span id="ss_mwt">380.37</span>. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. </p> <form class="form-inline"> <input type="hidden" name="max_concentration" id="max_concentration_value" value="10"> <div class="form-group"> Select a batch to recalculate based on the batch molecular weight: <div class="select_wrapper"> <select id="ss_select" class="form-control input-sm" name="batch"> <option value="380.37"></option> <option value="380.37">1</option> </select> </div> <button class="btn btn-quinary" id="recalc_stock_soln_data">Recalculate</button> </div> </form> <table class="table table-bordered"> <tr> <th>Concentration / Solvent Volume / Mass</th> <th>1 mg</th> <th>5 mg</th> <th>10 mg</th> </tr> <tr> <td>0.1 mM</td> <td id="ss_0_1_1">26.29 mL</td> <td id="ss_0_1_5">131.45 mL</td> <td id="ss_0_1_10">262.9 mL</td> </tr> <tr> <td>0.5 mM</td> <td id="ss_0_5_1">5.26 mL</td> <td id="ss_0_5_5">26.29 mL</td> <td id="ss_0_5_10">52.58 mL</td> </tr> <tr> <td>1 mM</td> <td id="ss_1_1">2.63 mL</td> <td id="ss_1_5">13.15 mL</td> <td id="ss_1_10">26.29 mL</td> </tr> <tr> <td>5 mM</td> <td id="ss_5_1">0.53 mL</td> <td id="ss_5_5">2.63 mL</td> <td id="ss_5_10">5.26 mL</td> </tr> </table> <div class="datasheet_calculators"> <div class="datasheet_molarity_calculator btn btn-secondary"><div class="calc_wrapper"> <div class="dsSprite_calc"></div> <div class="fake_link" id="calc_molarity_link">Molarity Calculator</div> <div id="calc_molarity_wrapper" class="calc_function_wrapper"> <div class="calc_popup"> <div class="calc_close"> <div class="dsSprite_calc_close"></div> </div> <div class="calc_header"><h3>Molarity Calculator</h3></div> <div class="calc_subheader">Calculate the mass, volume, or concentration required for a solution.</div> <div class="molarity_framework"> <div id="molarity_calculator" class="calculator"> <form id="molCalc"> <div class="calc_section"> <label for="molarity_calculator_mass" class="calculator_label">Mass</label> <input id="molarity_calculator_mass" name="molarity_calculator_mass" type="text" maxlength="6" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="molarity_calculator_mass_unit" class="calculator_input calculator_select" name="molarity_calculator_mass_unit"> <option value="-12">picograms</option> <option value="-9">nanograms</option> <option value="-6">micrograms</option> <option value="-3" selected>milligrams</option> <option value="0">grams</option> <option value="3">kilograms</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="molarity_calculator_concentration" class="calculator_label">Concentration</label> <input id="molarity_calculator_concentration" name="molarity_calculator_concentration" type="text" maxlength="6" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="molarity_calculator_concentration_unit" class="calculator_input calculator_select" name="molarity_calculator_concentration_unit"> <option value="-15">femtomolar</option> <option value="-12">picomolar</option> <option value="-9">nanomolar</option> <option value="-6">micromolar</option> <option value="-3" selected>millimolar</option> <option value="0">molar</option> </select> </span> </div> <span class="calculator_multiply calculator_operator">x</span> <div class="calc_section"> <label for="molarity_calculator_volume" class="calculator_label">Volume</label> <input id="molarity_calculator_volume" name="molarity_calculator_volume" type="text" maxlength="6" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="molarity_calculator_volume_unit" class="calculator_input calculator_select" name="molarity_calculator_volume_unit"> <option value="-9">nanoliter</option> <option value="-6">microliter</option> <option value="-3" Selected>milliliter</option> <option value="0">liter</option> </select> </span> </div> <span class="calculator_multiply calculator_operator">x</span> <div class="calc_section"> <label for="molarity_calculator_molecular_weight" class="calculator_label">M. Wt*</label> <input id="molarity_calculator_molecular_weight" name="molarity_calculator_molecular_weight" type="text" maxlength="6" placeholder="mwt" class="calculator_input calculator_text" value="380.37"/> <span class="calculator_unit_label">g/mol</span> </div> <div id="molarity_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_molarity_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> <div> <p>*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).</p> </div> </form> </div> </div> </div> </div> </div> </div> <div class="datasheet_reconstitution_calculator btn btn-secondary"><div class="calc_wrapper"> <div class="dsSprite_calc"></div> <div class="fake_link" id="calc_reconstitution_link">Reconstitution Calculator</div> <div id="calc_reconstitution_wrapper" class="calc_function_wrapper"> <div class="calc_popup"> <div class="calc_close"> <div class="dsSprite_calc_close"></div> </div> <div class="calc_header"><h3>Reconstitution Calculator</h3></div> <div id="reconstitution_calculator" class="calculator"> <form id="recCalc"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume (to add to vial)</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass (in vial)</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </span> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Desired Reconstitution Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </span> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> </div> </div> </div> </div> <div class="datasheet_dilution_calculator btn btn-secondary"><div class="calc_wrapper"> <div class="dsSprite_calc"></div> <div class="fake_link" id="calc_dilution_link">Dilution Calculator</div> <div id="calc_dilution_wrapper" class="calc_function_wrapper"> <div class="calc_popup"> <div class="calc_close"> <div class="dsSprite_calc_close"></div> </div> <div class="calc_header"><h3>Dilution Calculator</h3></div> <div class="calc_subheader">Calculate the dilution required to prepare a stock solution.</div> <div class="dilution_framework"> <div id="dilution_calculator" class="calculator"> <form id="dilCalc"> <div class="dilution_calculator_text" id="dilution_calculator_instructions"> </div> <div class="calc_section"> <label for="dilution_calculator_concentration_1" class="calculator_label">Concentration 1</label> <input id="dilution_calculator_concentration_1" name="dilution_calculator_concentration_1" type="text" maxlength="6" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="dilution_calculator_concentration_1_unit" class="calculator_input calculator_select" name="dilution_calculator_concentration_1_unit"> <option value="femtomolar">femtomolar</option> <option value="picomolar">picomolar</option> <option value="nanomolar">nanomolar</option> <option value="micromolar">micromolar</option> <option value="millimolar" selected>millimolar</option> <option value="molar">molar</option> </select> </span> </div> <span class="calculator_multiply calculator_operator">x</span> <div class="calc_section"> <label for="dilution_calculator_volume_1" class="calculator_label">Volume 1</label> <input id="dilution_calculator_volume_1" name="dilution_calculator_volume_1" type="text" maxlength="6" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="dilution_calculator_volume_1_unit" class="calculator_input calculator_select" name="dilution_calculator_volume_1_unit"> <option value="nanoliter">nanoliter</option> <option value="microliter">microliter</option> <option value="milliliter" selected>milliliter</option> <option value="liter">liter</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="dilution_calculator_concentration_2" class="calculator_label">Concentration 2</label> <input id="dilution_calculator_concentration_2" name="dilution_calculator_concentration_2" type="text" maxlength="6" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="dilution_calculator_concentration_2_unit" class="calculator_input calculator_select" name="dilution_calculator_concentration_2_unit"> <option value="femtomolar">femtomolar</option> <option value="picomolar">picomolar</option> <option value="nanomolar">nanomolar</option> <option value="micromolar">micromolar</option> <option value="millimolar" selected>millimolar</option> <option value="molar">molar</option> </select> </span> </div> <span class="calculator_multiply calculator_operator">x</span> <div class="calc_section"> <label for="dilution_calculator_volume_2" class="calculator_label">Volume 2</label> <input id="dilution_calculator_volume_2" name="dilution_calculator_volume_2" type="text" maxlength="6" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="dilution_calculator_volume_2_unit" class="calculator_input calculator_select" name="dilution_calculator_volume_2_unit"> <option value="nanoliter">nanoliter</option> <option value="microliter">microliter</option> <option value="milliliter" selected>milliliter</option> <option value="liter">liter</option> </select> </span> </div> <div id="dilution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_dilution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> </div> </div> </div> </div> </div> </div> <div class="calculator_inline"></div> </div> <div id="ds_datasheets" class="datasheet_section"> <h2>Product Datasheets for BI 3231</h2> <div class="row"> <div class="col-sm-12 col-md-6"> <a target="_blank" title="View batch specific physical and chemical properties and analytical data for BI 3231 (Cat. No. 8039) )" class="datasheet_download" id="coa_link" href="https://documents.tocris.com/pdfs/tocris_coa/8039_1_coa.pdf?1732372445">Certificate of Analysis / Product Datasheet</a> <div class="visible-xs-block visible-sm-block datasheet_section_element"></div> </div> <div class="col-sm-12 col-md-6"> <a href="https://documents.tocris.com/pdfs/tocris_msds/8039_sds.pdf?1732327007" class="datasheet_download" id="safety_datasheet" target="_blank" title="View Safety Datasheet for BI 3231 (Cat. No. 8039)">Safety Datasheet</a> </div> </div> </div> <div id="ds_reference_data" class="datasheet_section"> <h2>References for BI 3231</h2> <p> <em>References are publications that support the biological activity of the product.</em> </p> <p> <span class="highlight">Thamm</span> <em>et al</em> (2023) <a href="https://www.ncbi.nlm.nih.gov/pubmed/36727857" rel="nofollow" target="_blank" title="View abstract"> Discovery of a novel potent and selective HSD17B13 inhibitor, BI-3231, a well-characterized chemical probe available for open science. </a> J.Med.Chem. <strong><em>66</em></strong> 2832 PMID: 36727857 <hr/> <p>If you know of a relevant reference for BI 3231, <a href="/suggest-reference/catnum/8039" rel="nofollow">please let us know</a>.</p> </div> <div class="rel_by_target datasheet_section"> <h2>View Related Products by Target</h2> <ul class="ds_rel_targets"> <li><a class="btn btn-quinary bottom-margin" href="/pharmacology/other-dehydrogenases" title="Browse all products for Other Dehydrogenases">Other Dehydrogenases</a></li><li><a class="btn btn-quinary bottom-margin" href="/pharmacology/dehydrogenases" title="Browse all products for Dehydrogenases">Dehydrogenases</a></li> </ul> </div> <div class="rel_by_action datasheet_section"> <h2>View Related Products by Product Action</h2> <p> <a class="btn btn-quinary bottom-margin" href="/pharmacology/other-dehydrogenases/inhibitors" title="Browse all Other Dehydrogenase Inhibitors">View all Other Dehydrogenase Inhibitors</a> </p> </div> <div class="product_keywords datasheet_section"> <p>Keywords: BI 3231, BI 3231 supplier, BI3231, hydroxysteroid, 17beta, 17b, dehydrogenase, 13, HSD17B13, inhibitor, inhibits, inhibitors, potent, selective, hepatocytes, NASH, non, alcoholic, steatohepatitis, Other, Dehydrogenases, 8039, Tocris Bioscience</p> </div> </div> </div><div class="tab_content tab_2" data-tab="2"><a id="product-citations"></a><div id="citations"> <div class="datasheet_section_element"> <h3><span class="citations">Citations for BI 3231</span></h3> <p> <em> Citations are publications that use Tocris products. </em> </p> <p>Currently there are no citations for BI 3231. Do you know of a great paper that uses BI 3231 from Tocris? <a href="/suggest-citation/catnum/8039" rel="nofollow">Please let us know</a>. </p> </div> </div> </div><div class="tab_content tab_3" data-tab="3"><a id="product-reviews"></a><h3>Reviews for BI 3231</h3> <div class="row datasheet_section"> <div class="col-md-6"> <p>There are currently no reviews for this product. Be the first to <a href="/reviews/8039" rel="nofollow">review BI 3231</a> and earn rewards! </p> </div> <div class="col-md-6"> <div class="well"> <h4>Have you used BI 3231?</h4> <h5><strong>Submit a review and receive an Amazon gift card.</strong></h5> <div class="review_reward_txt"> <p>$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image</p> <p>$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image</p> <p>$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image</p> </div> <a class="btn btn-quinary" href="/reviews/8039" rel="nofollow">Submit a Review</a> </div> </div> </div> </div><div class="tab_content tab_4" data-tab="4"><a id="product-literature"></a><div id="literature"> <h3>Literature in this Area</h3> <p>Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!</p> <p class="small">*Please note that Tocris will only send literature to established scientific business / institute addresses.</p> <hr/> <div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/product-guides/fullsize/815385.jpg?v=2" data-toggle="lightbox" data-title="Cancer Metabolism Research Product Guide" data-footer="<a href='/literature/literature-request/815385' rel='nofollow' title='Request copy of the Cancer Metabolism'>Request copy</a> or <a href='/literature/literature-request/p815385' rel='nofollow' title='Request PDF of the Cancer Metabolism'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/815385.jpg?v=2" alt="Cancer Metabolism Research Product Guide" class="img-fluid"></a></div> <h4>Cancer Metabolism Research Product Guide</h4> <p>This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:</p> <ul class='bullet_list'> <li>Glycolysis</li> <li>Tricarboxylic Acid Cycle</li> <li>Lipidogenesis</li> <li>1C Metabolism and Nucleic Acid Synthesis</li> <li>Drivers of Metabolic Reprogramming</li> <li>pH and Redox Balance</li> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/815385" rel="nofollow" title="Request copy of the Cancer Metabolism Research Product Guide">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p815385" rel="nofollow" title="Request PDF of the Cancer Metabolism Research Product Guide">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/product-guides" title="View all Product Guides & Listings">View all Product Guides & Listings</a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/482944.jpg?v=1" data-toggle="lightbox" data-title="Cancer Metabolism Poster" data-footer="<a href='/literature/literature-request/482944' rel='nofollow' title='Request copy of the Cancer Metabolism'>Request copy</a> or <a class=' pdf-download' href='https://resources.tocris.com/pdfs/literature/posters/cancer-metabolism-poster-2022.pdf' download='https://resources.tocris.com/pdfs/literature/posters/cancer-metabolism-poster-2022.pdf' rel='nofollow' title='Download PDF of the Cancer Metabolism' data-title='Cancer Metabolism Poster'>Download PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/482944.jpg?v=1" alt="Cancer Metabolism Poster" class="img-fluid"></a></div> <h4>Cancer Metabolism Poster</h4> <p>This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.</p> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/482944" rel="nofollow" title="Request copy of the Cancer Metabolism Poster">Request copy</a> </li> <li><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/cancer-metabolism-poster-2022.pdf" download="https://resources.tocris.com/pdfs/literature/posters/cancer-metabolism-poster-2022.pdf" rel="nofollow" target="_blank" title="Download PDF of the Cancer Metabolism Poster" data-title="Cancer Metabolism Poster">Download PDF<div class="lit_pdf"></div></a></li> <li><a class="btn btn-quinary" href="/literature/life-science-posters" title="View all Life Science Posters">View all Life Science Posters</a></li> </ul> </div></div></div> </div></div></div><div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="distributor_region"></div>  <div class="widget"> <div class="widget_title">Literature in this Area</div> <div class="widget_content carousel slide" id="ds_literature_scroller" data-ride="carousel" data-interval="8000">  <div class="carousel-inner"><div class="item active"><div class="highlight">Cancer Metabolism Product Guide</div> <a href="/literature/product-guides/cancer-metabolism"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/815385.jpg?v=2" alt="Cancer Metabolism Research Product Guide"></a><p class="small">Our product guide reviews some of the main areas in cancer metabolism research and highlights products that can be used to explore metabolic pathways.</p><a class="btn btn-quinary" href="/literature/literature-request/815385" rel="nofollow" title="Request copy of the Cancer Metabolism Research Product Guide">Request copy</a><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p815385" rel="nofollow" title="Request PDF of the Cancer Metabolism Research Product Guide">Request PDF<div class="lit_request_pdf"></div></a></div><div class="item"><div class="highlight">Cancer Metabolism Life Science Poster</div><h5>Taken from the Cancer Product Guide Edition 3</h5> <a href="/literature/life-science-posters/cancer-metabolism"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/482944.jpg?v=1" alt="Cancer Metabolism Poster"></a><p class="small">Our Cancer Metabolism poster summarizes the main metabolic pathways in cancer cells, and highlights potential targets for cancer therapeutics.</p><a class="btn btn-quinary" href="/literature/literature-request/482944" rel="nofollow" title="Request copy of the Cancer Metabolism Poster">Request copy</a><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/cancer-metabolism-poster-2022.pdf" download="https://resources.tocris.com/pdfs/literature/posters/cancer-metabolism-poster-2022.pdf" rel="nofollow" target="_blank" title="Download PDF of the Cancer Metabolism Poster" data-title="Cancer Metabolism Poster">Download PDF<div class="lit_pdf"></div></a></div></div>  <a class="left carousel-control" href="#ds_literature_scroller" role="button" data-slide="prev"> <span class="icon-prev" aria-hidden="true"></span> <span class="sr-only">Previous</span> </a> <a class="right carousel-control" href="#ds_literature_scroller" role="button" data-slide="next"> <span class="icon-next" aria-hidden="true"></span> <span class="sr-only">Next</span> </a> </div> </div> <div class="widget"> <div class="sidebar-box-wrapper"> <a href="/reviews/8039" title="Submit a Product Review" rel="nofollow"><img loading="lazy" alt="Submit a Product Review" class="fp_four_box_image" src="//resources.tocris.com/images/homepage/featured/reviews.jpg"></a> <article class="box-content"> <h3> <a href="/reviews/8039" title="Submit a Product Review" rel="nofollow">Submit a Review & Earn an Amazon Gift Card</a> </h3> <p>You can now submit reviews for your favorite Tocris products. 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