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<span>Funkcije IL-17 familije</span> </div> </a> <ul id="toc-Funkcije_IL-17_familije-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Genetska_ekspresija_IL-17_familije" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Genetska_ekspresija_IL-17_familije"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Genetska ekspresija IL-17 familije</span> </div> </a> <ul id="toc-Genetska_ekspresija_IL-17_familije-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Regulacija_IL-17_ekspresije" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Regulacija_IL-17_ekspresije"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Regulacija IL-17 ekspresije</span> </div> </a> <ul id="toc-Regulacija_IL-17_ekspresije-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Proteinska_struktura_IL-17_familije" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Proteinska_struktura_IL-17_familije"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Proteinska struktura IL-17 familije</span> </div> </a> <ul id="toc-Proteinska_struktura_IL-17_familije-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Distribucija_i_signaliziranje_IL-17_receptorske_familije" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Distribucija_i_signaliziranje_IL-17_receptorske_familije"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Distribucija i signaliziranje IL-17 receptorske familije</span> </div> </a> <ul id="toc-Distribucija_i_signaliziranje_IL-17_receptorske_familije-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Spoljašnje veze</span> </div> </a> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Prikaži/sakrij sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Prikaži/sakrij sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading" lang="sh-Latn" dir="ltr"><span class="mw-page-title-main">Interleukin 17</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Prijedi na druge jezične varijante članka. Dostupno je na 11 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-11" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">11 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A5%D9%86%D8%AA%D8%B1%D9%84%D9%88%D9%83%D9%8A%D9%86_17" title="إنترلوكين 17 — Arapski" lang="ar" hreflang="ar" data-title="إنترلوكين 17" data-language-autonym="العربية" data-language-local-name="Arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Interleukin_17" title="Interleukin 17 — Engleski" lang="en" hreflang="en" data-title="Interleukin 17" data-language-autonym="English" data-language-local-name="Engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Interleucina-17" title="Interleucina-17 — Španski" lang="es" hreflang="es" data-title="Interleucina-17" data-language-autonym="Español" data-language-local-name="Španski" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%D9%86%D8%AA%D8%B1%D9%84%D9%88%DA%A9%DB%8C%D9%86_%DB%B1%DB%B7" title="اینترلوکین ۱۷ — Persijski" lang="fa" hreflang="fa" data-title="اینترلوکین ۱۷" data-language-autonym="فارسی" data-language-local-name="Persijski" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Interleukine_17" title="Interleukine 17 — Francuski" lang="fr" hreflang="fr" data-title="Interleukine 17" data-language-autonym="Français" data-language-local-name="Francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Interleucina_17" title="Interleucina 17 — Galski" lang="gl" hreflang="gl" data-title="Interleucina 17" data-language-autonym="Galego" data-language-local-name="Galski" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Interleuchina_17" title="Interleuchina 17 — Italijanski" lang="it" hreflang="it" data-title="Interleuchina 17" data-language-autonym="Italiano" data-language-local-name="Italijanski" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A4%E3%83%B3%E3%82%BF%E3%83%BC%E3%83%AD%E3%82%A4%E3%82%AD%E3%83%B3-17" title="インターロイキン-17 — Japanski" lang="ja" hreflang="ja" data-title="インターロイキン-17" data-language-autonym="日本語" data-language-local-name="Japanski" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukina_17" title="Interleukina 17 — Poljski" lang="pl" hreflang="pl" data-title="Interleukina 17" data-language-autonym="Polski" data-language-local-name="Poljski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Interleucina_17" title="Interleucina 17 — Portugalski" lang="pt" hreflang="pt" data-title="Interleucina 17" data-language-autonym="Português" data-language-local-name="Portugalski" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_17" title="Интерлеукин 17 — Srpski" lang="sr" hreflang="sr" data-title="Интерлеукин 17" data-language-autonym="Српски / srpski" data-language-local-name="Srpski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q99486570#sitelinks-wikipedia" title="Uredi međujezične poveznice" class="wbc-editpage">Uredi veze</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div 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title="Pogledajte listu svih stranica koje vode ovamo [j]" accesskey="j"><span>Šta vodi ovamo</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Posebno:Povezane_izmjene/Interleukin_17" rel="nofollow" title="Prelistajte nedavne izmjene stranica koje su povezane s ovom [k]" accesskey="k"><span>Povezane izmjene</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Posebno:Posebne_stranice" title="Pregledajte listu svih posebnih stranica [q]" accesskey="q"><span>Posebne stranice</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Interleukin_17&oldid=41417605" title="Nabavite trajnu vezu do ove verzije stranice"><span>Trajna veza</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Interleukin_17&action=info" title="Pronađite više informacija o ovoj stranici"><span>Podaci o stranici</span></a></li><li id="t-cite" class="mw-list-item"><a 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</nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Pomagala"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Izgled"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Izgled</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">premjesti 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title="Interleukin 17A">Interleukin 17A</a> </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Identifikatori </th></tr> <tr> <th style="background-color: #e7dcc3">Simbol </th> <td style="background-color: #eee"><a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL17A</a> </td></tr> <tr> <th style="background-color: #e7dcc3">Alt. simboli </th> <td style="background-color: #eee">IL17, CTLA8 </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=3605&rn=1">3605</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Organizacija_za_ljudski_genom" title="Organizacija za ljudski genom">Hugo</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=5981">5981</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603149&rn=1">603149</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">RefSek</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://genome.ucsc.edu/cgi-bin/hgTracks?Submit=Submit&position=NP_002181&rn=1">NP_002181</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/Q16552">Q16552</a> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Drugi podaci </th></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Lokus_(genetika)" title="Lokus (genetika)">Lokus</a> </th> <td style="background-color: #eee"><a href="/wiki/Hromozom_6_(%C4%8Dovek)" title="Hromozom 6 (čovek)">Hrom. 6</a> <i><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p12">p12</a></i> </td></tr> </tbody></table> </td></tr> <tr> <td> <table class="infobox" style="width: 22em; font-size: 88%; text-align: left; line-height: 1.5em"> <tbody><tr> <th colspan="2" style="text-align: center; font-size: 125%">Interleukin 17B </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Identifikatori </th></tr> <tr> <th style="background-color: #e7dcc3">Simbol </th> <td style="background-color: #eee">IL17B </td></tr> <tr> <th style="background-color: #e7dcc3">Alt. simboli </th> <td style="background-color: #eee">, ZCOTO7 </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=27190&rn=1">27190</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Organizacija_za_ljudski_genom" title="Organizacija za ljudski genom">Hugo</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=5982">5982</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604627&rn=1">604627</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">RefSek</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://genome.ucsc.edu/cgi-bin/hgTracks?Submit=Submit&position=NP_055258&rn=1">NP_055258</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/Q9UHF5">Q9UHF5</a> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Drugi podaci </th></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Lokus_(genetika)" title="Lokus (genetika)">Lokus</a> </th> <td style="background-color: #eee"><a href="/wiki/Hromozom_5_(%C4%8Dovek)" title="Hromozom 5 (čovek)">Hrom. 5</a> <i><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=5q32-34">q32-34</a></i> </td></tr> </tbody></table> </td></tr> <tr> <td> <table class="infobox" style="width: 22em; font-size: 88%; text-align: left; line-height: 1.5em"> <tbody><tr> <th colspan="2" style="text-align: center; font-size: 125%">Interleukin 17C </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Identifikatori </th></tr> <tr> <th style="background-color: #e7dcc3">Simbol </th> <td style="background-color: #eee">IL17C </td></tr> <tr> <th style="background-color: #e7dcc3">Alt. simboli </th> <td style="background-color: #eee">, CX2 </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=271989&rn=1">271989</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Organizacija_za_ljudski_genom" title="Organizacija za ljudski genom">Hugo</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=5983">5983</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604628&rn=1">604628</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">RefSek</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://genome.ucsc.edu/cgi-bin/hgTracks?Submit=Submit&position=NP_037410&rn=1">NP_037410</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/Q9P0M4">Q9P0M4</a> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Drugi podaci </th></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Lokus_(genetika)" title="Lokus (genetika)">Lokus</a> </th> <td style="background-color: #eee"><a href="/wiki/Hromozom_16_(%C4%8Dovek)" title="Hromozom 16 (čovek)">Hrom. 16</a> <i><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=16q24">q24</a></i> </td></tr> </tbody></table> </td></tr> <tr> <td> <table class="infobox" style="width: 22em; font-size: 88%; text-align: left; line-height: 1.5em"> <tbody><tr> <th colspan="2" style="text-align: center; font-size: 125%">Interleukin 17D </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Identifikatori </th></tr> <tr> <th style="background-color: #e7dcc3">Simbol </th> <td style="background-color: #eee">IL17D </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=53342&rn=1">53342</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Organizacija_za_ljudski_genom" title="Organizacija za ljudski genom">Hugo</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=5984">5984</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607587&rn=1">607587</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">RefSek</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://genome.ucsc.edu/cgi-bin/hgTracks?Submit=Submit&position=NP_612141&rn=1">NP_612141</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/Q8TAD2">Q8TAD2</a> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Drugi podaci </th></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Lokus_(genetika)" title="Lokus (genetika)">Lokus</a> </th> <td style="background-color: #eee"><a href="/wiki/Hromozom_13_(%C4%8Dovek)" title="Hromozom 13 (čovek)">Hrom. 13</a> <i><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=13q11">q11</a></i> </td></tr> </tbody></table> </td></tr> <tr> <td> <table class="infobox" style="width: 22em; font-size: 88%; text-align: left; line-height: 1.5em"> <tbody><tr> <th colspan="2" style="text-align: center; font-size: 125%">Interleukin 17E </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Identifikatori </th></tr> <tr> <th style="background-color: #e7dcc3">Simbol </th> <td style="background-color: #eee">IL17E </td></tr> <tr> <th style="background-color: #e7dcc3">Alt. simboli </th> <td style="background-color: #eee">, <a href="/wiki/Interleukin_25" title="Interleukin 25">IL-25</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=64806&rn=1">64806</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Organizacija_za_ljudski_genom" title="Organizacija za ljudski genom">Hugo</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=13765">13765</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605658&rn=1">605658</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">RefSek</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://genome.ucsc.edu/cgi-bin/hgTracks?Submit=Submit&position=NP_073626&rn=1">NP_073626</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/Q9H293">Q9H293</a> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Drugi podaci </th></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Lokus_(genetika)" title="Lokus (genetika)">Lokus</a> </th> <td style="background-color: #eee"><a href="/wiki/Hromozom_14_(%C4%8Dovek)" title="Hromozom 14 (čovek)">Hrom. 14</a> <i><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=14q11.2">q11.2</a></i> </td></tr> </tbody></table> </td></tr> <tr> <td> <table class="infobox" style="width: 22em; font-size: 88%; text-align: left; line-height: 1.5em"> <tbody><tr> <th colspan="2" style="text-align: center; font-size: 125%">Interleukin 17F </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Identifikatori </th></tr> <tr> <th style="background-color: #e7dcc3">Simbol </th> <td style="background-color: #eee">IL17F </td></tr> <tr> <th style="background-color: #e7dcc3">Alt. simboli </th> <td style="background-color: #eee">, ML-1 </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=112744&rn=1">112744</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Organizacija_za_ljudski_genom" title="Organizacija za ljudski genom">Hugo</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?hgnc_id=16404">16404</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606496&rn=1">606496</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">RefSek</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://genome.ucsc.edu/cgi-bin/hgTracks?Submit=Submit&position=NP_443104&rn=1">NP_443104</a> </td></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a> </th> <td style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/Q96PD4">Q96PD4</a> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Drugi podaci </th></tr> <tr> <th style="background-color: #e7dcc3"><a href="/wiki/Lokus_(genetika)" title="Lokus (genetika)">Lokus</a> </th> <td style="background-color: #eee"><a href="/wiki/Hromozom_6_(%C4%8Dovek)" title="Hromozom 6 (čovek)">Hrom. 6</a> <i><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p12">p12</a></i> </td></tr> </tbody></table> </td></tr></tbody></table> <p><b>Interleukin 17</b> (IL-17, ili <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a>) je osnivački član grupe <a href="/wiki/Citokin" title="Citokin">citokina</a> poznatih kao IL-17 familija. <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a>, je originalno (<a href="/wiki/1993" title="1993">1993</a>. godine) identifikovan kao <a href="/w/index.php?title=Transkript&action=edit&redlink=1" class="new" title="Transkript (stranica ne postoji)">transkript</a> iz <a href="/wiki/Glodar" class="mw-redirect" title="Glodar">glodarskih</a> <a href="/wiki/T-%C4%87elija" title="T-ćelija">T-ćelijskih</a> <a href="/w/index.php?title=Hibridoma&action=edit&redlink=1" class="new" title="Hibridoma (stranica ne postoji)">hibridoma</a>. On je poznat kao CTLA8 kod glodara. IL-17 je visoko homologan sa IL-17 kodiranim sa <a href="/w/index.php?title=Otvoreno_%C4%8Ditaju%C4%87i_okvir&action=edit&redlink=1" class="new" title="Otvoreno čitajući okvir (stranica ne postoji)">otvoreno čitajućim okvirom</a> T limfotropnog <a href="/w/index.php?title=Rhadinovirus&action=edit&redlink=1" class="new" title="Rhadinovirus (stranica ne postoji)">rhadinovirusa</a> <i>Herpesvirus saimiri</i>.<sup id="cite_ref-pmid8390535_1-0" class="reference"><a href="#cite_note-pmid8390535-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> IL-17 dejstvuje putem vezivanja za tip I receptor na ćelijskoj površini sa imenom <a href="/w/index.php?title=Interleukin-17_receptor&action=edit&redlink=1" class="new" title="Interleukin-17 receptor (stranica ne postoji)">IL-17R</a>. Postoje tri varijante <a href="/w/index.php?title=IL17RA&action=edit&redlink=1" class="new" title="IL17RA (stranica ne postoji)">IL17RA</a>, <a href="/w/index.php?title=IL17RB&action=edit&redlink=1" class="new" title="IL17RB (stranica ne postoji)">IL17RB</a>, i <a href="/w/index.php?title=IL17RC&action=edit&redlink=1" class="new" title="IL17RC (stranica ne postoji)">IL17RC</a>.<sup id="cite_ref-pmid12097364_2-0" class="reference"><a href="#cite_note-pmid12097364-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Članovi_IL-17_familije"><span id=".C4.8Clanovi_IL-17_familije"></span>Članovi IL-17 familije</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&veaction=edit&section=1" title="Uredi odjeljak Članovi IL-17 familije" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_17&action=edit&section=1" title="Uredi kôd odjeljka Članovi IL-17 familije"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Pored <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a>, članovi IL-17 familije su <a href="/w/index.php?title=IL-17B&action=edit&redlink=1" class="new" title="IL-17B (stranica ne postoji)">IL-17B</a>, <a href="/w/index.php?title=IL-17C&action=edit&redlink=1" class="new" title="IL-17C (stranica ne postoji)">IL-17C</a>, <a href="/w/index.php?title=IL-17D&action=edit&redlink=1" class="new" title="IL-17D (stranica ne postoji)">IL-17D</a>, <a href="/w/index.php?title=IL-17E&action=edit&redlink=1" class="new" title="IL-17E (stranica ne postoji)">IL-17E</a> (koji se još zove <a href="/wiki/Interleukin_25" title="Interleukin 25">IL-25</a>), i <a href="/w/index.php?title=IL-17F&action=edit&redlink=1" class="new" title="IL-17F (stranica ne postoji)">IL-17F</a>. Svi članovi IL-17 familije imaju sličnu <a href="/wiki/Protein" title="Protein">proteinsku</a> strukturu, sa četiri visoko prezervisana <a href="/wiki/Cistein" title="Cistein">cisteinska</a> ostatka koji su kritični za njihov <a href="/w/index.php?title=Tri-dimenzionalni_prostor&action=edit&redlink=1" class="new" title="Tri-dimenzionalni prostor (stranica ne postoji)">3-dimenzionalni</a> oblik, mada oni nemaju slične sekvence sa bilo kojim drugim citokinom. <a href="/wiki/Filogenetika" class="mw-redirect" title="Filogenetika">Filogenetička</a> analiza je ustanovila da među članovima IL-17 familije, <a href="/w/index.php?title=IL-17F&action=edit&redlink=1" class="new" title="IL-17F (stranica ne postoji)">IL-17F</a> izoforme 1 i 2 (ML-1) imaju najviši stepen homologije sa <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a> (deleći 55 i 40% <a href="/wiki/Aminokiselina" title="Aminokiselina">aminokiselinskog</a> identiteta sa <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a> respektivno), njih slede <a href="/w/index.php?title=IL-17B&action=edit&redlink=1" class="new" title="IL-17B (stranica ne postoji)">IL-17B</a> (29%), <a href="/w/index.php?title=IL-17D&action=edit&redlink=1" class="new" title="IL-17D (stranica ne postoji)">IL-17D</a> (25%), <a href="/w/index.php?title=IL-17C&action=edit&redlink=1" class="new" title="IL-17C (stranica ne postoji)">IL-17C</a> (23%), i <a href="/w/index.php?title=IL-17E&action=edit&redlink=1" class="new" title="IL-17E (stranica ne postoji)">IL-17E</a> (17%). Ovi citokini su visoko konzervirani kod <a href="/wiki/Sisar" class="mw-redirect" title="Sisar">sisara</a>, sa čak 62–88% aminokiselina konzerviranih između ljudskog i mišjeg homologa.<sup id="cite_ref-Kolls2004_4-0" class="reference"><a href="#cite_note-Kolls2004-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Funkcije_IL-17_familije">Funkcije IL-17 familije</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&veaction=edit&section=2" title="Uredi odjeljak Funkcije IL-17 familije" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_17&action=edit&section=2" title="Uredi kôd odjeljka Funkcije IL-17 familije"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Brojne imuno regulatorne funkcije su objavljene za citokine IL-17 familije, što je posledica njihove sposobnosti da indukuju mnoge imune signalne molekule.<sup id="cite_ref-KubyImmunology6th_5-0" class="reference"><a href="#cite_note-KubyImmunology6th-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Najznačajnijih IL-17 uloga je njegovo učešće u podsticanju i posredovanju proinflamatorni odgovora. IL-17 je često povezan sa alergijskim reakcijama. IL-17 izaziva proizvodnju mnogih drugih citokina (kao što su <a href="/wiki/IL-6" class="mw-disambig" title="IL-6">IL-6</a>, <a href="/w/index.php?title=G-CSF&action=edit&redlink=1" class="new" title="G-CSF (stranica ne postoji)">G-CSF</a>, <a href="/w/index.php?title=GM-CSF&action=edit&redlink=1" class="new" title="GM-CSF (stranica ne postoji)">GM-CSF</a>, <a href="/wiki/Interleukin-1" class="mw-redirect" title="Interleukin-1">IL-1β</a>, <a href="/w/index.php?title=TGF-%CE%B2&action=edit&redlink=1" class="new" title="TGF-β (stranica ne postoji)">TGF-β</a>, <a href="/wiki/TNF-%CE%B1" class="mw-redirect" title="TNF-α">TNF-α</a>), <a href="/wiki/Hemokin" title="Hemokin">hemokina</a> (uključujući <a href="/wiki/IL-8" class="mw-disambig" title="IL-8">IL-8</a>, <a href="/w/index.php?title=GRO-alfa&action=edit&redlink=1" class="new" title="GRO-alfa (stranica ne postoji)">GRO-α</a>, i <a href="/wiki/MCP-1" class="mw-redirect" title="MCP-1">MCP-1</a>), i <a href="/wiki/Prostaglandin" title="Prostaglandin">prostaglandina</a> (npr. <a href="/wiki/PGE2" class="mw-redirect" title="PGE2">PGE<sub>2</sub></a>) iz mnogih ćelijskih tipova (<a href="/wiki/Fibroblast" title="Fibroblast">fibroblasta</a>, <a href="/w/index.php?title=Endotelijalne_%C4%87elije&action=edit&redlink=1" class="new" title="Endotelijalne ćelije (stranica ne postoji)">endotelijalnih ćelije</a>, <a href="/w/index.php?title=Epitelijalnih_%C4%87elija&action=edit&redlink=1" class="new" title="Epitelijalnih ćelija (stranica ne postoji)">epitelijalnih ćelija</a>, <a href="/w/index.php?title=Keratinocit&action=edit&redlink=1" class="new" title="Keratinocit (stranica ne postoji)">keratinocita</a>, i <a href="/w/index.php?title=Makrofaga&action=edit&redlink=1" class="new" title="Makrofaga (stranica ne postoji)">makrofaga</a>). Oslobađanje citokina izaziva mnoge funkcije, kao što je remodelovanje vazdušnih kanala, koji je karakteristika IL-17 odziva. Povećana <a href="/wiki/Ekspresija_gena" title="Ekspresija gena">ekspresija</a> <a href="/wiki/Hemokin" title="Hemokin">hemokina</a> privlači druge ćelije uključujući <a href="/wiki/Neutrofil" title="Neutrofil">neutrofile</a>, ali ne <a href="/w/index.php?title=Eosinofil&action=edit&redlink=1" class="new" title="Eosinofil (stranica ne postoji)">eosinofile</a>. IL-17 funkcija je isto esencijalna za podskup <a href="/w/index.php?title=CD4&action=edit&redlink=1" class="new" title="CD4 (stranica ne postoji)">CD4</a>+ T-ćelija zvanih <a href="/wiki/T_pomo%C4%87ne_17_%C4%87elije" title="T pomoćne 17 ćelije">T pomoćne 17</a> (T<sub>h</sub>17) ćelije. Kao rezultat ovikvog profile, IL-17 familija je bila vezana za mnoge imune/autoimune bolesti uključujući <a href="/wiki/Reumatoidni_artritis" title="Reumatoidni artritis">reumatoidni artritis</a>, <a href="/wiki/Astma" title="Astma">astma</a>, <a href="/wiki/Lupus" title="Lupus">lupus</a>, <a href="/w/index.php?title=Alograft&action=edit&redlink=1" class="new" title="Alograft (stranica ne postoji)">alograft</a> odbacivanje i antitumorski imunitet.<sup id="cite_ref-aggaral_6-0" class="reference"><a href="#cite_note-aggaral-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Genetska_ekspresija_IL-17_familije">Genetska ekspresija IL-17 familije</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&veaction=edit&section=3" title="Uredi odjeljak Genetska ekspresija IL-17 familije" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_17&action=edit&section=3" title="Uredi kôd odjeljka Genetska ekspresija IL-17 familije"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Gen" title="Gen">Gen</a> za ljudski IL-17 sadrži 1874 <a href="/wiki/Bazni_par" title="Bazni par">baznih parova</a><sup id="cite_ref-Yao1995_7-0" class="reference"><a href="#cite_note-Yao1995-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>, i bio je kloniran iz CD4+ T ćelija. Svaki član IL-17 familije ima poseban obrazac ćelijske <a href="/wiki/Ekspresija_gena" title="Ekspresija gena">ekspresije</a>. Izražavanje <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a> i <a href="/w/index.php?title=IL-17F&action=edit&redlink=1" class="new" title="IL-17F (stranica ne postoji)">IL-17F</a> gena izgleda da je ograničeno na malu grupu aktiviranih <a href="/w/index.php?title=T_%C4%87elija&action=edit&redlink=1" class="new" title="T ćelija (stranica ne postoji)">T ćelija</a>, i povećano je u toku <a href="/wiki/Inflamacija" class="mw-disambig" title="Inflamacija">inflamacije</a>. <a href="/w/index.php?title=IL-17B&action=edit&redlink=1" class="new" title="IL-17B (stranica ne postoji)">IL-17B</a> je izražen u perifernim tkivima i imunim tkivima. <a href="/w/index.php?title=IL-17C&action=edit&redlink=1" class="new" title="IL-17C (stranica ne postoji)">IL-17C</a> je takođe visoko izražen pod <a href="/wiki/Zapaljenje" class="mw-redirect" title="Zapaljenje">inflamatornim</a> uslovima, dok je u normalnim okolnostima minimalno prisutan. <a href="/w/index.php?title=IL-17D&action=edit&redlink=1" class="new" title="IL-17D (stranica ne postoji)">IL-17D</a> je visoko izražen u <a href="/wiki/Nervni_sistem" title="Nervni sistem">nervnom sistemu</a> i <a href="/w/index.php?title=Skeletalni_mi%C5%A1i%C4%87i&action=edit&redlink=1" class="new" title="Skeletalni mišići (stranica ne postoji)">skeletalnim mišićima</a>, i <a href="/w/index.php?title=IL-17E&action=edit&redlink=1" class="new" title="IL-17E (stranica ne postoji)">IL-17E</a> se nalazi u niskim nivoima u različitim perifernim tkivima.<sup id="cite_ref-aggaral_6-1" class="reference"><a href="#cite_note-aggaral-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Regulacija_IL-17_ekspresije">Regulacija IL-17 ekspresije</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&veaction=edit&section=4" title="Uredi odjeljak Regulacija IL-17 ekspresije" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_17&action=edit&section=4" title="Uredi kôd odjeljka Regulacija IL-17 ekspresije"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Značajan progres je napravljen u razumevanju IL-17 regulacije. Jedan od prvih koraka je bilo otkriće da je IL-17 produkcija zavisna od <a href="/wiki/Interleukin_23" title="Interleukin 23">IL-23</a>.<sup id="cite_ref-pmid12417590_8-0" class="reference"><a href="#cite_note-pmid12417590-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Nakon toga je demonstrirano da su <a href="/w/index.php?title=STAT&action=edit&redlink=1" class="new" title="STAT (stranica ne postoji)">STAT3</a> i <a href="/w/index.php?title=NF-%CE%BAB&action=edit&redlink=1" class="new" title="NF-κB (stranica ne postoji)">NF-κB</a> signalni putevi neophodni za IL-23-posredovanu IL-17 produkciju.<sup id="cite_ref-pmid16622035_9-0" class="reference"><a href="#cite_note-pmid16622035-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Saglasno sa ovim nalazima, ustanovljeno je da još jedan molekul, <a href="/w/index.php?title=SOCS3&action=edit&redlink=1" class="new" title="SOCS3 (stranica ne postoji)">SOCS3</a>, igra važnu ulogu u IL-17 produkciji.<sup id="cite_ref-pmid16698929_10-0" class="reference"><a href="#cite_note-pmid16698929-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> U odsustvu SOCS3, IL-23-inducirana STAT3 <a href="/wiki/Fosforilacija" title="Fosforilacija">fosforilacija</a> je povećana, i fosforisani STAT3 se vezuje za <a href="/w/index.php?title=Promotor&action=edit&redlink=1" class="new" title="Promotor (stranica ne postoji)">promotor</a> regione oba <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a> i <a href="/w/index.php?title=IL-17F&action=edit&redlink=1" class="new" title="IL-17F (stranica ne postoji)">IL-17F</a> povećavajući njihovu gensku aktivnost. U kontrastu s tim, neki naučnici tvrde da je IL-17 indukcija nezavisna od <a href="/wiki/IL-23" class="mw-disambig" title="IL-23">IL-23</a>. Nekoliko grupa su identifikovale načine da indukuju IL-17 produkciju <i>in vitro</i><sup id="cite_ref-Veldhoen2006_11-0" class="reference"><a href="#cite_note-Veldhoen2006-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> i <i>in vivo</i><sup id="cite_ref-Mangan2006_12-0" class="reference"><a href="#cite_note-Mangan2006-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bettelli2006_13-0" class="reference"><a href="#cite_note-Bettelli2006-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> pomoću citokina <a href="/w/index.php?title=TGF-%CE%B2&action=edit&redlink=1" class="new" title="TGF-β (stranica ne postoji)">TGF-β</a> i <a href="/wiki/IL-6" class="mw-disambig" title="IL-6">IL-6</a>, bez potrebe za IL-23.<sup id="cite_ref-Veldhoen2006_11-1" class="reference"><a href="#cite_note-Veldhoen2006-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Mangan2006_12-1" class="reference"><a href="#cite_note-Mangan2006-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bettelli2006_13-1" class="reference"><a href="#cite_note-Bettelli2006-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Mada IL-23 nije neophodan za IL-17 izražavanje u ovoj situaciji, IL-23 može da igra ulogu u promovisanju opstanka i/ili proliferacije <a href="/wiki/T-%C4%87elija" title="T-ćelija">T-ćelija</a> koje proizvode IL-17. Nedavno je ustanovljeno da <a href="/wiki/Timus" title="Timus">timus</a> specifični <a href="/w/index.php?title=Nuklearni_receptor&action=edit&redlink=1" class="new" title="Nuklearni receptor (stranica ne postoji)">nuklearni receptor</a>, <a href="/w/index.php?title=RAR-srodni_siro%C4%8De_receptor_gama&action=edit&redlink=1" class="new" title="RAR-srodni siroče receptor gama (stranica ne postoji)">ROR-γ</a>, usmerava diferencijaciju <a href="/wiki/T_pomo%C4%87ne_17_%C4%87elije" title="T pomoćne 17 ćelije">Th17</a> ćelija.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Proteinska_struktura_IL-17_familije">Proteinska struktura IL-17 familije</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&veaction=edit&section=5" title="Uredi odjeljak Proteinska struktura IL-17 familije" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_17&action=edit&section=5" title="Uredi kôd odjeljka Proteinska struktura IL-17 familije"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-17(A) je <a href="/wiki/Protein" title="Protein">protein</a> sa 155-aminokiselina. On je <a href="/wiki/Disulfid" title="Disulfid">disulfidno</a>-vezan, homodimerni, sekretivni <a href="/wiki/Glikoprotein" title="Glikoprotein">glikoprotein</a> sa molekulskom masom od 35 <a href="/wiki/Jedinica_atomske_mase" title="Jedinica atomske mase">kDa</a>.<sup id="cite_ref-Kolls2004_4-1" class="reference"><a href="#cite_note-Kolls2004-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Svaka jedinica homodimera ima masu od aproksimalno 15-20 <a href="/wiki/Jedinica_atomske_mase" title="Jedinica atomske mase">kDa</a>. IL-17 struktura se sastoji od <a href="/wiki/Signalni_peptid" title="Signalni peptid">signalnog peptida</a> sa 23 aminokiseline (ak), čemu sledi 123-ak region karakterističan za IL-17 familiju. Jedno N-vezano mesto <a href="/wiki/Glikozilacija" title="Glikozilacija">glikozilacije</a> na <a href="/wiki/Protein" title="Protein">proteinu</a> je prvo identifikovano nakon prečišćavanja proteina. Poređenje različitih članova IL-17 familije je ukazalo na četiri konzervirana <a href="/wiki/Cistein" title="Cistein">cisteina</a> koji formiraju dva <a href="/wiki/Disulfidni_most" class="mw-redirect" title="Disulfidni most">disulfidna mosta</a>.<sup id="cite_ref-Yao1995_7-1" class="reference"><a href="#cite_note-Yao1995-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> IL-17 je jedinstven po tome što nema sličnosti sa drugim <a href="/wiki/Interleukin" title="Interleukin">interleukinims</a>. Štaviše, IL-17 nije sličan nijednom drugom poznatom <a href="/wiki/Protein" title="Protein">proteinu</a> ili strukturnom domenu.<sup id="cite_ref-aggaral_6-2" class="reference"><a href="#cite_note-aggaral-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p><a href="/w/index.php?title=IL-17F&action=edit&redlink=1" class="new" title="IL-17F (stranica ne postoji)">IL-17F</a> kristalna struktura, koja je 50% homologna sa <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a>, poseduje strukturnu sličnost sa 'cisteinski-čvor' familijom proteina u koju spadaju <a href="/w/index.php?title=Neutrotrofin&action=edit&redlink=1" class="new" title="Neutrotrofin (stranica ne postoji)">neutrotrofini</a>. <a href="/w/index.php?title=Cisteinski_%C4%8Dvor&action=edit&redlink=1" class="new" title="Cisteinski čvor (stranica ne postoji)">Cisteinski čvor</a> presavijanje je karakterisano sa dva seta uparenih <a href="/w/index.php?title=Beta-struka&action=edit&redlink=1" class="new" title="Beta-struka (stranica ne postoji)">β-struka</a> stabilizovanih sa tri disulfidne interakcije. Međutim, u kontrastu sa drugim cisteinski-čvor proteinima <a href="/w/index.php?title=IL-17F&action=edit&redlink=1" class="new" title="IL-17F (stranica ne postoji)">IL-17F</a> nema treći disulfidni most. Umesto toga <a href="/wiki/Serin" title="Serin">serin</a> zamenjuje cistein. Ova jedinstvena osobina je konzervirana kod drugih članova IL-17 familije. <a href="/w/index.php?title=IL-17F&action=edit&redlink=1" class="new" title="IL-17F (stranica ne postoji)">IL-17F</a> se takođe dimerizuje na način sličan <a href="/w/index.php?title=Nervni_faktor_rast&action=edit&redlink=1" class="new" title="Nervni faktor rast (stranica ne postoji)">nervnom faktoru rasta</a> (NGF) i drugim neutrotrofinima.<sup id="cite_ref-pmid11574464_15-0" class="reference"><a href="#cite_note-pmid11574464-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Distribucija_i_signaliziranje_IL-17_receptorske_familije">Distribucija i signaliziranje IL-17 receptorske familije</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&veaction=edit&section=6" title="Uredi odjeljak Distribucija i signaliziranje IL-17 receptorske familije" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_17&action=edit&section=6" title="Uredi kôd odjeljka Distribucija i signaliziranje IL-17 receptorske familije"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/w/index.php?title=IL-17_receptor&action=edit&redlink=1" class="new" title="IL-17 receptor (stranica ne postoji)">IL-17 receptorska</a> familija se sastoji od pet, široko distribuiranih receptora koji su specifični za individualne ligande. U ovoj familiji receptora, <a href="/w/index.php?title=IL-17R&action=edit&redlink=1" class="new" title="IL-17R (stranica ne postoji)">IL-17R</a> je najbolje opisan. IL-17R vezuje oba <a href="/wiki/IL-17A" class="mw-redirect" title="IL-17A">IL-17A</a> i <a href="/w/index.php?title=IL-17F&action=edit&redlink=1" class="new" title="IL-17F (stranica ne postoji)">IL-17F</a>, i on je izražen u više tkiva: vaskularne endotelijske ćelije, periferne T ćelije, B ćelijske loze, fibroblast, pluća, mijelo-monocitne ćelije, i stromalne ćelije koštane srži.<sup id="cite_ref-Kolls2004_4-2" class="reference"><a href="#cite_note-Kolls2004-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kawaguchi2004_16-0" class="reference"><a href="#cite_note-Kawaguchi2004-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Moseley2003_17-0" class="reference"><a href="#cite_note-Moseley2003-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p><p><a href="/w/index.php?title=IL-17RB&action=edit&redlink=1" class="new" title="IL-17RB (stranica ne postoji)">IL-17RB</a>, vezuje <a href="/w/index.php?title=IL-17B&action=edit&redlink=1" class="new" title="IL-17B (stranica ne postoji)">IL-17B</a> i <a href="/w/index.php?title=IL-17E&action=edit&redlink=1" class="new" title="IL-17E (stranica ne postoji)">IL-17E</a>.<sup id="cite_ref-Kolls2004_4-3" class="reference"><a href="#cite_note-Kolls2004-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Moseley2003_17-1" class="reference"><a href="#cite_note-Moseley2003-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> On je izražen u bubrezima, pankreasu, jetri, mozgu, i crevima.<sup id="cite_ref-Kolls2004_4-4" class="reference"><a href="#cite_note-Kolls2004-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> <a href="/w/index.php?title=IL-17RC&action=edit&redlink=1" class="new" title="IL-17RC (stranica ne postoji)">IL-17RC</a> je izražen u prostati, hrskavici, bubrezima, jetri, srcu i mišićima. NJegov gen podleže <a href="/wiki/Alternativno_splajsovanje" title="Alternativno splajsovanje">alternativnom splajsovanju</a> i proizvodi rastvorni receptor, u dodatku obliku receptora vezanom za ćelijsku membranu. U sličnom maniru, <a href="/w/index.php?title=IL-17RD&action=edit&redlink=1" class="new" title="IL-17RD (stranica ne postoji)">IL-17RD</a> gen može podleći alternativnom splajsovanju da proizvede rastvorni receptor. Ova osobina možda omogućava ovim receptorima da inhibiraju stimulatorne efekte njihovih još-nedefinisanih liganda.<sup id="cite_ref-Kolls2004_4-5" class="reference"><a href="#cite_note-Kolls2004-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Moseley2003_17-2" class="reference"><a href="#cite_note-Moseley2003-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Najmanje opisan od ovih receptora je <a href="/w/index.php?title=IL-17RE&action=edit&redlink=1" class="new" title="IL-17RE (stranica ne postoji)">IL-17RE</a>, za koji se zna da je izražen u pankreasu, mozgu, i prostati.<sup id="cite_ref-Kolls2004_4-6" class="reference"><a href="#cite_note-Kolls2004-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>Transdukcija signala ovim receptorima je raznovrsna koliko i njihova distribucija. Transkripcioni faktori kao što su <a href="/w/index.php?title=TRAF&action=edit&redlink=1" class="new" title="TRAF (stranica ne postoji)">TRAF6</a>, <a href="/w/index.php?title=Janus_kinaza&action=edit&redlink=1" class="new" title="Janus kinaza (stranica ne postoji)">JNK</a>, <a href="/w/index.php?title=Erk_kinaza&action=edit&redlink=1" class="new" title="Erk kinaza (stranica ne postoji)">Erk1/2</a>, <a href="/w/index.php?title=P38&action=edit&redlink=1" class="new" title="P38 (stranica ne postoji)">p38</a>, <a href="/w/index.php?title=AP-1&action=edit&redlink=1" class="new" title="AP-1 (stranica ne postoji)">AP-1</a> i <a href="/w/index.php?title=NF-%CE%BAB&action=edit&redlink=1" class="new" title="NF-κB (stranica ne postoji)">NF-κB</a> su bili implicirani u IL-17 posredovanu signalizaciju u stimulaciono-zavisnom, tkivno-specifičnom maniru.<sup id="cite_ref-Kawaguchi2004_16-1" class="reference"><a href="#cite_note-Kawaguchi2004-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Moseley2003_17-3" class="reference"><a href="#cite_note-Moseley2003-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16891673_18-0" class="reference"><a href="#cite_note-pmid16891673-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Drugi signalni mehanizmi su bili predloženi, ali je više rada potrebno da bi potpunije istražili signalni putevi koje ovi receptori koriste. </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&veaction=edit&section=7" title="Uredi odjeljak Reference" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_17&action=edit&section=7" title="Uredi kôd odjeljka Reference"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r41556849">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-pmid8390535-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid8390535_1-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (1993). <a rel="nofollow" class="external text" href="http://www.jimmunol.org/cgi/content/abstract/150/12/5445">„CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene”</a>. <i>J. Immunol.</i> <b>150</b> (12): 5445–56. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/8390535">8390535</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CTLA-8%2C+cloned+from+an+activated+T+cell%2C+bearing+AU-rich+messenger+RNA+instability+sequences%2C+and+homologous+to+a+herpesvirus+saimiri+gene&rft.jtitle=J.+Immunol.&rft.aulast=Rouvier+E%2C+Luciani+MF%2C+Matt%C3%A9i+MG%2C+Denizot+F%2C+Golstein+P&rft.au=Rouvier+E%2C+Luciani+MF%2C+Matt%C3%A9i+MG%2C+Denizot+F%2C+Golstein+P&rft.date=1993&rft.volume=150&rft.issue=12&rft.pages=5445%E2%80%9356&rft_id=info:pmid/8390535&rft_id=http%3A%2F%2Fwww.jimmunol.org%2Fcgi%2Fcontent%2Fabstract%2F150%2F12%2F5445&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-pmid12097364-2"><span class="mw-cite-backlink"><a href="#cite_ref-pmid12097364_2-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Starnes T, Broxmeyer HE, Robertson MJ, Hromas R (2002). <a rel="nofollow" class="external text" href="http://www.jimmunol.org/cgi/content/abstract/169/2/642">„Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis”</a>. <i>J. Immunol.</i> <b>169</b> (2): 642–6. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12097364">12097364</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cutting+edge%3A+IL-17D%2C+a+novel+member+of+the+IL-17+family%2C+stimulates+cytokine+production+and+inhibits+hemopoiesis&rft.jtitle=J.+Immunol.&rft.aulast=Starnes+T%2C+Broxmeyer+HE%2C+Robertson+MJ%2C+Hromas+R&rft.au=Starnes+T%2C+Broxmeyer+HE%2C+Robertson+MJ%2C+Hromas+R&rft.date=2002&rft.volume=169&rft.issue=2&rft.pages=642%E2%80%936&rft_id=info:pmid/12097364&rft_id=http%3A%2F%2Fwww.jimmunol.org%2Fcgi%2Fcontent%2Fabstract%2F169%2F2%2F642&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><span class="citation book">Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/book/9780124983403"><i>Cytokines (Handbook of Immunopharmacology)</i></a>. Boston: Academic Press. <a href="/wiki/International_Standard_Book_Number" class="mw-redirect" title="International Standard Book Number">ISBN</a> <a href="/wiki/Posebno:Tra%C5%BEi_ISBN/0-12-498340-5" title="Posebno:Traži ISBN/0-12-498340-5">0-12-498340-5</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Cytokines+%28Handbook+of+Immunopharmacology%29&rft.date=1998&rft.place=Boston&rft.pub=Academic+Press&rft.isbn=0-12-498340-5&rft_id=http%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Fbook%2F9780124983403&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Kolls2004-4"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Kolls2004_4-0">4,0</a></sup> <sup><a href="#cite_ref-Kolls2004_4-1">4,1</a></sup> <sup><a href="#cite_ref-Kolls2004_4-2">4,2</a></sup> <sup><a href="#cite_ref-Kolls2004_4-3">4,3</a></sup> <sup><a href="#cite_ref-Kolls2004_4-4">4,4</a></sup> <sup><a href="#cite_ref-Kolls2004_4-5">4,5</a></sup> <sup><a href="#cite_ref-Kolls2004_4-6">4,6</a></sup></span> <span class="reference-text"><span class="citation Journal">Kolls JK, Lindén A (2004). „Interleukin-17 family members and inflammation”. <i>Immunity</i> <b>21</b> (4): 467–76. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.immuni.2004.08.018">10.1016/j.immuni.2004.08.018</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15485625">15485625</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-17+family+members+and+inflammation&rft.jtitle=Immunity&rft.aulast=Kolls+JK%2C+Lind%C3%A9n+A&rft.au=Kolls+JK%2C+Lind%C3%A9n+A&rft.date=2004&rft.volume=21&rft.issue=4&rft.pages=467%E2%80%9376&rft_id=info:doi/10.1016%2Fj.immuni.2004.08.018&rft_id=info:pmid/15485625&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-KubyImmunology6th-5"><span class="mw-cite-backlink"><a href="#cite_ref-KubyImmunology6th_5-0">↑</a></span> <span class="reference-text"><span class="citation book">Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). <a rel="nofollow" class="external text" href="http://bcs.whfreeman.com/immunology6e/default.asp?s=&n=&i=&v=&o=&ns=0&uid=0&rau=0"><i>Kuby Immunology</i></a> (6 izd.). New York: W H Freeman and company. <a href="/wiki/International_Standard_Book_Number" class="mw-redirect" title="International Standard Book Number">ISBN</a> <a href="/wiki/Posebno:Tra%C5%BEi_ISBN/1-4292-0211-4" title="Posebno:Traži ISBN/1-4292-0211-4">1-4292-0211-4</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Kuby+Immunology&rft.aulast=Thomas+J.+Kindt%2C+Richard+A.+Goldsby%2C+Barbara+Anne+Osborne%2C+Janis+Kuby&rft.au=Thomas+J.+Kindt%2C+Richard+A.+Goldsby%2C+Barbara+Anne+Osborne%2C+Janis+Kuby&rft.date=2006&rft.edition=6&rft.place=New+York&rft.pub=W+H+Freeman+and+company&rft.isbn=1-4292-0211-4&rft_id=http%3A%2F%2Fbcs.whfreeman.com%2Fimmunology6e%2Fdefault.asp%3Fs%3D%26n%3D%26i%3D%26v%3D%26o%3D%26ns%3D0%26uid%3D0%26rau%3D0&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-aggaral-6"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-aggaral_6-0">6,0</a></sup> <sup><a href="#cite_ref-aggaral_6-1">6,1</a></sup> <sup><a href="#cite_ref-aggaral_6-2">6,2</a></sup></span> <span class="reference-text"><span class="citation Journal">Aggarwal S, Gurney AL (2002). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20100706025128/http://www.jleukbio.org/cgi/content/abstract/71/1/1">„IL-17: prototype member of an emerging cytokine family”</a>. <i>J. Leukoc. Biol.</i> <b>71</b> (1): 1–8. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/11781375">11781375</a>. Arhivirano iz <a rel="nofollow" class="external text" href="http://www.jleukbio.org/cgi/content/abstract/71/1/1">originala</a> na datum 2010-07-06<span class="reference-accessdate">. Pristupljeno 2014-05-23</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL-17%3A+prototype+member+of+an+emerging+cytokine+family&rft.jtitle=J.+Leukoc.+Biol.&rft.aulast=Aggarwal+S%2C+Gurney+AL&rft.au=Aggarwal+S%2C+Gurney+AL&rft.date=2002&rft.volume=71&rft.issue=1&rft.pages=1%E2%80%938&rft_id=info:pmid/11781375&rft_id=https%3A%2F%2Fweb.archive.org%2Fweb%2F20100706025128%2Fhttp%3A%2F%2Fwww.jleukbio.org%2Fcgi%2Fcontent%2Fabstract%2F71%2F1%2F1&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Yao1995-7"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Yao1995_7-0">7,0</a></sup> <sup><a href="#cite_ref-Yao1995_7-1">7,1</a></sup></span> <span class="reference-text"><span class="citation Journal">Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ (1995). <a rel="nofollow" class="external text" href="http://www.jimmunol.org/cgi/content/abstract/155/12/5483">„Human IL-17: a novel cytokine derived from T cells”</a>. <i>J. 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Chem.</i> <b>278</b> (3): 1910–4. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1074%2Fjbc.M207577200">10.1074/jbc.M207577200</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12417590">12417590</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-23+promotes+a+distinct+CD4+T+cell+activation+state+characterized+by+the+production+of+interleukin-17&rft.jtitle=J.+Biol.+Chem.&rft.aulast=Aggarwal+S%2C+Ghilardi+N%2C+Xie+MH%2C+de+Sauvage+FJ%2C+Gurney+AL&rft.au=Aggarwal+S%2C+Ghilardi+N%2C+Xie+MH%2C+de+Sauvage+FJ%2C+Gurney+AL&rft.date=2003&rft.volume=278&rft.issue=3&rft.pages=1910%E2%80%934&rft_id=info:doi/10.1074%2Fjbc.M207577200&rft_id=info:pmid/12417590&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-pmid16622035-9"><span class="mw-cite-backlink"><a href="#cite_ref-pmid16622035_9-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB, Jin HT, Min SY, Ju JH, Park KS, Cho YG, Yoon CH, Park SH, Sung YC, Kim HY (2006). <a rel="nofollow" class="external text" href="http://www.jimmunol.org/cgi/content/abstract/176/9/5652">„STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice”</a>. <i>J. 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Selective+regulatory+function+of+Socs3+in+the+formation+of+IL-17-secreting+T+cells&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.aulast=Chen+Z%2C+Laurence+A%2C+Kanno+Y%2C+Pacher-Zavisin+M%2C+Zhu+BM%2C+Tato+C%2C+Yoshimura+A%2C+Hennighausen+L%2C+O%27Shea+JJ&rft.au=Chen+Z%2C+Laurence+A%2C+Kanno+Y%2C+Pacher-Zavisin+M%2C+Zhu+BM%2C+Tato+C%2C+Yoshimura+A%2C+Hennighausen+L%2C+O%27Shea+JJ&rft.date=2006&rft.volume=103&rft.issue=21&rft.pages=8137%E2%80%9342&rft_id=info:doi/10.1073%2Fpnas.0600666103&rft_id=info:pmid/16698929&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Veldhoen2006-11"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Veldhoen2006_11-0">11,0</a></sup> <sup><a href="#cite_ref-Veldhoen2006_11-1">11,1</a></sup></span> <span class="reference-text"><span class="citation Journal">Veldhoen M, 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=TGFbeta+in+the+context+of+an+inflammatory+cytokine+milieu+supports+de+novo+differentiation+of+IL-17-producing+T+cells&rft.jtitle=Immunity&rft.aulast=Veldhoen+M%2C+Hocking+RJ%2C+Atkins+CJ%2C+Locksley+RM%2C+Stockinger+B&rft.au=Veldhoen+M%2C+Hocking+RJ%2C+Atkins+CJ%2C+Locksley+RM%2C+Stockinger+B&rft.date=2006&rft.volume=24&rft.issue=2&rft.pages=179%E2%80%9389&rft_id=info:doi/10.1016%2Fj.immuni.2006.01.001&rft_id=info:pmid/16473830&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Mangan2006-12"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Mangan2006_12-0">12,0</a></sup> <sup><a href="#cite_ref-Mangan2006_12-1">12,1</a></sup></span> <span class="reference-text"><span class="citation Journal">Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transforming+growth+factor-beta+induces+development+of+the+T%28H%2917+lineage&rft.jtitle=Nature&rft.aulast=Mangan+PR%2C+Harrington+LE%2C+O%27Quinn+DB%2C+Helms+WS%2C+Bullard+DC%2C+Elson+CO%2C+Hatton+RD%2C+Wahl+SM%2C+Schoeb+TR%2C+Weaver+CT&rft.au=Mangan+PR%2C+Harrington+LE%2C+O%27Quinn+DB%2C+Helms+WS%2C+Bullard+DC%2C+Elson+CO%2C+Hatton+RD%2C+Wahl+SM%2C+Schoeb+TR%2C+Weaver+CT&rft.date=2006&rft.volume=441&rft.issue=7090&rft.pages=231%E2%80%934&rft_id=info:doi/10.1038%2Fnature04754&rft_id=info:pmid/16648837&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Bettelli2006-13"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Bettelli2006_13-0">13,0</a></sup> <sup><a href="#cite_ref-Bettelli2006_13-1">13,1</a></sup></span> <span class="reference-text"><span class="citation Journal">Bettelli E, Carrier Y, Gao 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Reciprocal+developmental+pathways+for+the+generation+of+pathogenic+effector+TH17+and+regulatory+T+cells&rft.jtitle=Nature&rft.aulast=Bettelli+E%2C+Carrier+Y%2C+Gao+W%2C+Korn+T%2C+Strom+TB%2C+Oukka+M%2C+Weiner+HL%2C+Kuchroo+VK&rft.au=Bettelli+E%2C+Carrier+Y%2C+Gao+W%2C+Korn+T%2C+Strom+TB%2C+Oukka+M%2C+Weiner+HL%2C+Kuchroo+VK&rft.date=2006&rft.volume=441&rft.issue=7090&rft.pages=235%E2%80%938&rft_id=info:doi/10.1038%2Fnature04753&rft_id=info:pmid/16648838&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><a href="#cite_ref-14">↑</a></span> <span class="reference-text">Ivanov, II, B.S. 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Allergy Clin. Immunol.</i> <b>114</b> (6): 1265–73; quiz 1274. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.jaci.2004.10.019">10.1016/j.jaci.2004.10.019</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15577820">15577820</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL-17+cytokine+family&rft.jtitle=J.+Allergy+Clin.+Immunol.&rft.aulast=Kawaguchi+M%2C+Adachi+M%2C+Oda+N%2C+Kokubu+F%2C+Huang+SK&rft.au=Kawaguchi+M%2C+Adachi+M%2C+Oda+N%2C+Kokubu+F%2C+Huang+SK&rft.date=2004&rft.volume=114&rft.issue=6&rft.pages=1265%E2%80%9373%3B+quiz+1274&rft_id=info:doi/10.1016%2Fj.jaci.2004.10.019&rft_id=info:pmid/15577820&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_journal-of-allergy-and-clinical-immunology_2004-12_114_6%2Fpage%2F1265&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Moseley2003-17"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Moseley2003_17-0">17,0</a></sup> <sup><a href="#cite_ref-Moseley2003_17-1">17,1</a></sup> <sup><a href="#cite_ref-Moseley2003_17-2">17,2</a></sup> <sup><a href="#cite_ref-Moseley2003_17-3">17,3</a></sup></span> <span class="reference-text"><span class="citation Journal">Moseley TA, Haudenschild DR, Rose L, Reddi AH (2003). „Interleukin-17 family and IL-17 receptors”. <i>Cytokine Growth Factor Rev.</i> <b>14</b> (2): 155–74. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2FS1359-6101%2803%2900002-9">10.1016/S1359-6101(03)00002-9</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12651226">12651226</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-17+family+and+IL-17+receptors&rft.jtitle=Cytokine+Growth+Factor+Rev.&rft.aulast=Moseley+TA%2C+Haudenschild+DR%2C+Rose+L%2C+Reddi+AH&rft.au=Moseley+TA%2C+Haudenschild+DR%2C+Rose+L%2C+Reddi+AH&rft.date=2003&rft.volume=14&rft.issue=2&rft.pages=155%E2%80%9374&rft_id=info:doi/10.1016%2FS1359-6101%2803%2900002-9&rft_id=info:pmid/12651226&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-pmid16891673-18"><span class="mw-cite-backlink"><a href="#cite_ref-pmid16891673_18-0">↑</a></span> <span class="reference-text"><span class="citation Journal">Ley K, Smith E, Stark MA (2006). „IL-17A-producing neutrophil-regulatory Tn lymphocytes”. <i>Immunol. Res.</i> <b>34</b> (3): 229–42. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1385%2FIR%3A34%3A3%3A229">10.1385/IR:34:3:229</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/16891673">16891673</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL-17A-producing+neutrophil-regulatory+Tn+lymphocytes&rft.jtitle=Immunol.+Res.&rft.aulast=Ley+K%2C+Smith+E%2C+Stark+MA&rft.au=Ley+K%2C+Smith+E%2C+Stark+MA&rft.date=2006&rft.volume=34&rft.issue=3&rft.pages=229%E2%80%9342&rft_id=info:doi/10.1385%2FIR%3A34%3A3%3A229&rft_id=info:pmid/16891673&rfr_id=info:sid/en.wikipedia.org:Interleukin_17"><span style="display: none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Spoljašnje_veze"><span id="Spolja.C5.A1nje_veze"></span>Spoljašnje veze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&veaction=edit&section=8" title="Uredi odjeljak Spoljašnje veze" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin_17&action=edit&section=8" title="Uredi kôd odjeljka Spoljašnje veze"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Medical_Subject_Headings" class="mw-redirect" title="Medical Subject Headings">MeSH</a> <i><a rel="nofollow" class="external text" href="//www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=Interleukin-17">Interleukin-17</a></i></li></ul> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/Cytokines" title="Cytokines"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/12px-Commons-logo.svg.png" decoding="async" width="12" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/24px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <a href="https://commons.wikimedia.org/wiki/Main_page" class="extiw" title="commons:Main page">Wikimedia Commons</a> ima još multimedijalnih datoteka vezanih za: <b><i><a href="https://commons.wikimedia.org/wiki/Category:Cytokines" class="extiw" title="commons:Category:Cytokines">Interleukin 17</a></i></b></li></ul> <div style="clear:both;"></div> <div class="navbox-styles nomobile"><style data-mw-deduplicate="TemplateStyles:r41348688">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid 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šablonu" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">r</abbr></a></li><li class="nv-uredi"><a class="external text" href="https://sh.wikipedia.org/w/index.php?title=%C5%A0ablon:Interleukini-lat&action=edit"><abbr title="Uredite šablon" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">u</abbr></a></li></ul></div><div id="Interleukini" style="font-size:114%;margin:0 4em"><a href="/wiki/Interleukini" class="mw-redirect" title="Interleukini">Interleukini</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_1" title="Interleukin 1">IL-1</a> •  <a href="/wiki/Interleukin_2" title="Interleukin 2">IL-2</a> •  <a href="/wiki/Interleukin_3" title="Interleukin 3">IL-3</a> •  <a href="/wiki/Interleukin_4" title="Interleukin 4">IL-4</a> •  <a href="/wiki/Interleukin_5" title="Interleukin 5">IL-5</a> •  <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a> •  <a href="/wiki/Interleukin_7" title="Interleukin 7">IL-7</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">IL-8</a> •  <a href="/wiki/Interleukin_9" title="Interleukin 9">IL-9</a> •  <a href="/wiki/Interleukin_10" title="Interleukin 10">IL-10</a> •  <a href="/wiki/Interleukin_11" title="Interleukin 11">IL-11</a> •  <a href="/wiki/Interleukin_12" title="Interleukin 12">IL-12</a> (<a href="/wiki/Interleukin_12B" title="Interleukin 12B">B</a>) •  <a href="/wiki/Interleukin_13" title="Interleukin 13">IL-13</a> •  <a href="/wiki/Interleukin_14" title="Interleukin 14">IL-14</a> •  <a href="/wiki/Interleukin_15" title="Interleukin 15">IL-15</a> •  <a href="/wiki/Interleukin_16" title="Interleukin 16">IL-16</a> •  <a class="mw-selflink selflink">IL-17</a> (<a href="/wiki/Interleukin_17A" title="Interleukin 17A">A</a>) •  <a href="/wiki/Interleukin_18" title="Interleukin 18">IL-18</a> •  <a href="/wiki/Interleukin_19" title="Interleukin 19">IL-19</a> •  <a href="/wiki/Interleukin_20" title="Interleukin 20">IL-20</a> •  <a href="/wiki/Interleukin_21" title="Interleukin 21">IL-21</a> •  <a href="/wiki/Interleukin_22" title="Interleukin 22">IL-22</a> •  <a href="/wiki/Interleukin_23" title="Interleukin 23">IL-23</a> •  <a href="/wiki/Interleukin_24" title="Interleukin 24">IL-24</a> •  <a href="/wiki/Interleukin_25" title="Interleukin 25">IL-25</a> •  <a href="/wiki/Interleukin_26" title="Interleukin 26">IL-26</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">IL-27</a> •  <a href="/wiki/Interleukin_28" title="Interleukin 28">IL-28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">IL-29</a> •  <a href="/wiki/Interleukin_30" title="Interleukin 30">IL-30</a> •  <a href="/wiki/Interleukin_31" title="Interleukin 31">IL-31</a> •  <a href="/wiki/Interleukin_32" title="Interleukin 32">IL-32</a> •  <a href="/wiki/Interleukin_33" title="Interleukin 33">IL-33</a> •  <a href="/wiki/Interleukin_34" title="Interleukin 34">IL-34</a> •  <a href="/wiki/Interleukin_35" title="Interleukin 35">IL-35</a></div></td></tr></tbody></table></div> <div class="navbox-styles nomobile"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r41348688"></div><div role="navigation" class="navbox" aria-labelledby="Ćelijska_komunikacija:_Citokini" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r41556979"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r41556873"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-prikaži"><a href="/wiki/%C5%A0ablon:Citokini-lat" title="Šablon:Citokini-lat"><abbr title="Pogledajte šablon" 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class="navbox-group" style="width:1%;background-color: AntiqueWhite">Po familiji</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-1" class="mw-disambig" title="IL-1">IL-1</a> superfamilija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_1" title="Interleukin 1">1</a> (<a href="/wiki/Antagonist_interleukin-1_receptora" title="Antagonist interleukin-1 receptora">1Ra</a>) •  <a href="/wiki/Interleukin_18" title="Interleukin 18">18</a> •  <a href="/wiki/Interleukin_33" title="Interleukin 33">33</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">poput <a href="/wiki/IL-6" class="mw-disambig" title="IL-6">IL-6</a>/<a href="/wiki/Glikoprotein_130" title="Glikoprotein 130">gp130</a> koristeći</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_6" title="Interleukin 6">6</a>  •  <a href="/wiki/Interleukin_11" title="Interleukin 11">11</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">27</a> •  <a href="/wiki/Interleukin_30" title="Interleukin 30">30</a> •  <a href="/wiki/Interleukin_31" title="Interleukin 31">31</a> (+ne IL <a href="/wiki/Onkostatin_M" title="Onkostatin M">Onkostatin M</a>, <a href="/wiki/Inhibitorni_faktor_leukemije" title="Inhibitorni faktor leukemije">Inhibitorni faktor leukemije</a>, <a href="/wiki/Cilijarni_neurotrofni_faktor" title="Cilijarni neurotrofni faktor">Cilijarni neurotrofni faktor</a>, <a href="/wiki/Kardiotrofin_1" title="Kardiotrofin 1">Kardiotrofin 1</a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-10" class="mw-disambig" title="IL-10">IL-10</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_10" title="Interleukin 10">10</a> •  <a href="/wiki/Interleukin_19" title="Interleukin 19">19</a> •  <a href="/wiki/Interleukin_20" title="Interleukin 20">20</a> •  <a href="/wiki/Interleukin_22" title="Interleukin 22">22</a> •  <a href="/wiki/Interleukin_24" title="Interleukin 24">24</a> •  <a href="/wiki/Interleukin_26" title="Interleukin 26">26</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_III" title="Interferon tip III">Interferon tip III</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_28" title="Interleukin 28">28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">29</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Zajedni%C4%8Dki_gama_lanac" class="mw-redirect" title="Zajednički gama lanac">Zajednički γ-lanac</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_2" title="Interleukin 2">2</a>/<a href="/wiki/Interleukin_15" title="Interleukin 15">15</a> •  <a href="/wiki/Interleukin_3" title="Interleukin 3">3</a> •  <a href="/wiki/Interleukin_4" title="Interleukin 4">4</a> •  <a href="/wiki/Interleukin_7" title="Interleukin 7">7</a> •  <a href="/wiki/Interleukin_9" title="Interleukin 9">9</a> •  <a href="/wiki/Interleukin_13" title="Interleukin 13">13</a> •  <a href="/wiki/Interleukin_21" title="Interleukin 21">21</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-12" class="mw-disambig" title="IL-12">IL-12</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_12" title="Interleukin 12">12</a> (<a href="/wiki/Interleukin_12B" title="Interleukin 12B">B</a>) •  <a href="/wiki/Interleukin_23" title="Interleukin 23">23</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">27</a> •  <a href="/wiki/Interleukin_35" title="Interleukin 35">35</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">Drugi</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_5" title="Interleukin 5">5</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">8</a> •  <a href="/wiki/Interleukin_14" title="Interleukin 14">14</a> •  <a href="/wiki/Interleukin_16" title="Interleukin 16">16</a> •  <a class="mw-selflink selflink">17</a>/<a href="/wiki/Interleukin_25" title="Interleukin 25">25</a> (<a href="/wiki/Interleukin_17A" title="Interleukin 17A">A</a>) •  <a href="/wiki/Interleukin_32" title="Interleukin 32">32</a>  •  <a href="/wiki/Interleukin_34" title="Interleukin 34">34</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Hemokini" class="mw-redirect" title="Hemokini">Hemokini</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CCL</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CCL1" title="CCL1">1</a> •  <a href="/wiki/CCL2" title="CCL2">2</a> •  <a href="/wiki/Makrofagni_inflamatorni_protein" title="Makrofagni inflamatorni protein">3</a> •  <a href="/wiki/CCL4" title="CCL4">4</a> •  <a href="/wiki/CCL5" title="CCL5">5</a> •  <a href="/wiki/CCL6" title="CCL6">6</a> •  <a href="/wiki/CCL7" title="CCL7">7</a> •  <a href="/wiki/CCL8" title="CCL8">8</a> •  <a href="/wiki/CCL9" title="CCL9">9</a> •  <a href="/wiki/CCL9" title="CCL9">10</a> •  <a href="/wiki/CCL11" title="CCL11">11</a> •  <a href="/wiki/CCL12" title="CCL12">12</a> •  <a href="/wiki/CCL13" title="CCL13">13</a> •  <a href="/wiki/CCL14" title="CCL14">14</a> •  <a href="/wiki/CCL15" title="CCL15">15</a> •  <a href="/wiki/CCL16" title="CCL16">16</a> •  <a href="/wiki/CCL17" title="CCL17">17</a> •  <a href="/wiki/CCL18" title="CCL18">18</a> •  <a href="/wiki/CCL19" title="CCL19">19</a> •  <a href="/wiki/CCL20" title="CCL20">20</a> •  <a href="/wiki/CCL21" title="CCL21">21</a> •  <a href="/wiki/CCL22" title="CCL22">22</a> •  <a href="/wiki/CCL23" title="CCL23">23</a> •  <a href="/wiki/CCL24" title="CCL24">24</a> •  <a href="/wiki/CCL25" title="CCL25">25</a> •  <a href="/wiki/CCL26" title="CCL26">26</a> •  <a href="/wiki/CCL27" title="CCL27">27</a> •  <a href="/wiki/CCL28" title="CCL28">28</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CXCL</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CXCL1" title="CXCL1">1</a> •  <a href="/wiki/CXCL2" title="CXCL2">2</a> •  <a href="/wiki/CXCL3" title="CXCL3">3</a> •  <a href="/wiki/Trombocit_faktor_4" title="Trombocit faktor 4">4</a> •  <a href="/wiki/CXCL5" title="CXCL5">5</a> •  <a href="/wiki/CXCL6" title="CXCL6">6</a> •  <a href="/wiki/CXCL7" title="CXCL7">7</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">8</a> •  <a href="/wiki/CXCL9" title="CXCL9">9</a> •  <a href="/wiki/CXCL10" title="CXCL10">10</a> •  <a href="/wiki/CXCL11" title="CXCL11">11</a> •  <a href="/wiki/CXCL12" title="CXCL12">12</a> •  <a href="/wiki/CXCL13" title="CXCL13">13</a> •  <a href="/wiki/CXCL14" title="CXCL14">14</a> •  <a href="/wiki/CXCL15" title="CXCL15">15</a> •  <a href="/wiki/CXCL16" title="CXCL16">16</a> •  <a href="/wiki/CXCL17" title="CXCL17">17</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CX3CL</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CX3CL1" title="CX3CL1">1</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">XCL</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/XCL1" title="XCL1">1</a> •  <a href="/wiki/XCL2" title="XCL2">2</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Faktori_nekroze_tumora" title="Faktori nekroze tumora">TNF</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">Glavni</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Faktor_nekroze_tumora-alfa" title="Faktor nekroze tumora-alfa">TNF-alfa</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">TNF (<a href="/wiki/Ligand_(biohemija)" title="Ligand (biohemija)">ligand</a>) superfamilija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/4-1BB_ligand" title="4-1BB ligand">4-1BB ligand</a> •  <a href="/wiki/Faktor_aktivacije_B-%C4%87elija" title="Faktor aktivacije B-ćelija">Faktor aktivacije B-ćelija</a> •  <a href="/wiki/Fas_ligand" title="Fas ligand">FAS ligand</a> •  <a href="/wiki/Limfotoksin" title="Limfotoksin">Limfotoksin</a> •  <a href="/wiki/OX40L" title="OX40L">OX40L</a> •  <a href="/wiki/RANKL" title="RANKL">RANKL</a> •  <a href="/wiki/TRAIL" title="TRAIL">TRAIL</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Klaster_diferencijacije" title="Klaster diferencijacije">Klaster diferencijacije</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CD70" title="CD70">CD70</a> •  <a href="/wiki/CD153" title="CD153">CD153</a> •  <a href="/wiki/CD154" title="CD154">CD154</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon" title="Interferon">Interferon</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_I" title="Interferon tip I">I</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">alfa ( <a href="/wiki/Pegilirani_interferon_alfa-2a" title="Pegilirani interferon alfa-2a">Pegilirani 2a</a>, <a href="/wiki/Pegilirani_interferon_alfa-2b" title="Pegilirani interferon alfa-2b">Pegilirani 2b</a>), beta (<a href="/wiki/Interferon_beta-1a" title="Interferon beta-1a">1a</a>, <a href="/wiki/Interferon_beta-1b" title="Interferon beta-1b">1b</a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_II" title="Interferon tip II">II</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interferon-gama" title="Interferon-gama">Gama</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_III" title="Interferon tip III">III</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_28" title="Interleukin 28">IL-28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">IL-29</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Drugi</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Monokin" title="Monokin">Monokin</a> •  <a href="/wiki/Limfokin" title="Limfokin">Limfokin</a> (<a href="/wiki/Limfotoksin" title="Limfotoksin">Limfotoksin</a>, <a href="/wiki/Faktor_transfera" title="Faktor transfera">Faktor transfera</a>) •  <a href="/wiki/Faktor_rasta" title="Faktor rasta">Faktor rasta</a> •  <a href="/wiki/Hematopoeza" title="Hematopoeza">Hematopoeza</a> (<a href="/wiki/Faktor_stem_%C4%87elija" title="Faktor stem ćelija">Faktor stem ćelija</a>, <a href="/wiki/Faktor_stimulacije_kolonije" title="Faktor stimulacije kolonije">Faktor stimulacije kolonije</a>) •  <a href="/wiki/GPI_(gen)" title="GPI (gen)">Faktor autokrinog motiliteta</a> •  <a href="/wiki/Osteopontin" title="Osteopontin">Osteopontin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Po funkciji</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><i><a href="/wiki/Proinflamatorni_citokin" title="Proinflamatorni citokin">proinflamatorni citokin</a></i> (<a href="/wiki/Interleukin_1" title="Interleukin 1">IL-1</a>, <a href="/wiki/Faktor_nekroze_tumora-alfa" title="Faktor nekroze tumora-alfa">TNF-alfa</a>) •  <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije"><i>T<sub>h</sub>1</i></a> (<a href="/wiki/Interferon-gama" title="Interferon-gama">INF-gama</a> i <a href="/wiki/Faktor_nekroze_tumora-beta" class="mw-redirect" title="Faktor nekroze tumora-beta">TNF-beta</a>) •  <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije"><i>T<sub>h</sub>2</i></a> (<a href="/wiki/Interleukin_4" title="Interleukin 4">IL-4</a>, <a href="/wiki/Interleukin_5" title="Interleukin 5">IL-5</a>, <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a>, <a href="/wiki/Interleukin_10" title="Interleukin 10">IL-10</a>, <a href="/wiki/Interleukin_13" title="Interleukin 13">IL-13</a>) •  <a href="/wiki/T_pomo%C4%87ne_17_%C4%87elije" title="T pomoćne 17 ćelije"><i>T<sub>h</sub>17</i></a> (<a class="mw-selflink selflink">IL-17</a>,<a href="/wiki/Interleukin_22" title="Interleukin 22">IL-22</a>)</div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i><a href="/wiki/%C5%A0ablon:Biohemija_metanavs-lat" title="Šablon:Biohemija metanavs-lat">B</a> <a href="/wiki/%C5%A0ablon:Prenos_signala-lat" title="Šablon:Prenos signala-lat">trdu</a>: <a href="/w/index.php?title=%C5%A0ablon:Intercelularni_signalni_peptidi_i_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Intercelularni signalni peptidi i proteini-lat (stranica ne postoji)">peptidi</a> (<a href="/wiki/%C5%A0ablon:Neuropeptidi-lat" title="Šablon:Neuropeptidi-lat">nrpl</a>/<a href="/wiki/%C5%A0ablon:Faktori_rasta-lat" title="Šablon:Faktori rasta-lat">grfl</a>/<a href="/wiki/%C5%A0ablon:Citokini-lat" title="Šablon:Citokini-lat">cytl</a>/<a href="/wiki/%C5%A0ablon:Hormoni-lat" title="Šablon:Hormoni-lat">horl</a>), <a href="/w/index.php?title=%C5%A0ablon:Receptori_%C4%87elijske_povr%C5%A1ine-lat&action=edit&redlink=1" class="new" title="Šablon:Receptori ćelijske površine-lat (stranica ne postoji)">receptori</a> (<a href="/w/index.php?title=%C5%A0ablon:Ligand-kontrolisani_jonski_kanali-lat&action=edit&redlink=1" class="new" title="Šablon:Ligand-kontrolisani jonski kanali-lat (stranica ne postoji)">lgic</a>, <a href="/w/index.php?title=%C5%A0ablon:Enzim-vezani_receptori-lat&action=edit&redlink=1" class="new" title="Šablon:Enzim-vezani receptori-lat (stranica ne postoji)">enzr</a>, <a href="/wiki/%C5%A0ablon:G_protein_spregnuti_receptori-lat" title="Šablon:G protein spregnuti receptori-lat">gprc</a>, <a href="/wiki/%C5%A0ablon:Imunoglobulinska_superfamilija_imunskih_receptora-lat" title="Šablon:Imunoglobulinska superfamilija imunskih receptora-lat">igsr</a>, <a href="/w/index.php?title=%C5%A0ablon:Integrini-lat&action=edit&redlink=1" class="new" title="Šablon:Integrini-lat (stranica ne postoji)">intg</a>, <a href="/wiki/%C5%A0ablon:Neuropeptidni_receptori-lat" title="Šablon:Neuropeptidni receptori-lat">nrpr</a>/<a href="/wiki/%C5%A0ablon:Receptori_faktora_rasta-lat" title="Šablon:Receptori faktora rasta-lat">grfr</a>/<a href="/wiki/%C5%A0ablon:Citokinski_receptori-lat" class="mw-redirect" title="Šablon:Citokinski receptori-lat">cytr</a>), <a href="/w/index.php?title=%C5%A0ablon:Intracelularni_signalni_peptidi_i_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Intracelularni signalni peptidi i proteini-lat (stranica ne postoji)">itra</a> (<a href="/w/index.php?title=%C5%A0ablon:Adapterski_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Adapterski proteini-lat (stranica ne postoji)">adap</a>, <a href="/wiki/%C5%A0ablon:Regulatori_GTP-vezuju%C4%87ih_proteina-lat" title="Šablon:Regulatori GTP-vezujućih proteina-lat">gbpr</a>, <a href="/w/index.php?title=%C5%A0ablon:Aktivacija_MAP_kinaze-lat&action=edit&redlink=1" class="new" title="Šablon:Aktivacija MAP kinaze-lat (stranica ne postoji)">mapk</a>), <a href="/w/index.php?title=%C5%A0ablon:Kalcjiumska_signalizacija-lat&action=edit&redlink=1" class="new" title="Šablon:Kalcjiumska signalizacija-lat (stranica ne postoji)">calc</a>, <a href="/wiki/%C5%A0ablon:Lipidna_signalizacija-lat" title="Šablon:Lipidna signalizacija-lat">lipd</a>, signalni putevi (<a href="/w/index.php?title=%C5%A0ablon:Hedgehog_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Hedgehog signalni put-lat (stranica ne postoji)">hedp</a>, <a href="/w/index.php?title=%C5%A0ablon:Wnt_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Wnt signalni put-lat (stranica ne postoji)">wntp</a>, <a href="/w/index.php?title=%C5%A0ablon:TGF_beta_signalizacija-lat&action=edit&redlink=1" class="new" title="Šablon:TGF beta signalizacija-lat (stranica ne postoji)">tgfp</a>+<a href="/wiki/%C5%A0ablon:MAPK_ERK_signalni_put-lat" title="Šablon:MAPK ERK signalni put-lat">mapp</a>, <a href="/w/index.php?title=%C5%A0ablon:Notch_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Notch signalni put-lat (stranica ne postoji)">notp</a>, <a href="/w/index.php?title=%C5%A0ablon:JAK-STAT_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:JAK-STAT signalni put-lat (stranica ne postoji)">jakp</a>, <a href="/wiki/%C5%A0ablon:Apoptozni_signalni_put-lat" title="Šablon:Apoptozni signalni put-lat">fsap</a>, <a href="/w/index.php?title=%C5%A0ablon:Hippo_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Hippo signalni put-lat (stranica ne postoji)">hipp</a>, <a href="/w/index.php?title=%C5%A0ablon:TLR_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:TLR signalni put-lat (stranica ne postoji)">tlrp</a>)</i></div></td></tr></tbody></table></div>    </div><noscript><img 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