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class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Idrolisi_del_legame_peptidico"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Idrolisi del legame peptidico</span> </div> </a> <ul id="toc-Idrolisi_del_legame_peptidico-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Note" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Note"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Note</span> </div> </a> <ul id="toc-Note-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Voci_correlate" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Voci_correlate"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Voci correlate</span> </div> </a> <ul id="toc-Voci_correlate-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Altri_progetti" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Altri_progetti"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Altri progetti</span> </div> </a> <ul id="toc-Altri_progetti-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Collegamenti_esterni" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Collegamenti_esterni"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Collegamenti esterni</span> </div> </a> <ul id="toc-Collegamenti_esterni-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Indice" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Mostra/Nascondi l'indice" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Mostra/Nascondi l'indice</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Legame peptidico</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Vai a una voce in un'altra lingua. Disponibile in 50 lingue" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-50" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">50 lingue</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%B1%D8%A7%D8%A8%D8%B7%D8%A9_%D8%A8%D8%A8%D8%AA%D9%8A%D8%AF%D9%8A%D8%A9" title="رابطة ببتيدية - arabo" lang="ar" hreflang="ar" data-title="رابطة ببتيدية" data-language-autonym="العربية" data-language-local-name="arabo" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%9F%D0%B5%D0%BF%D1%82%D1%8B%D0%B4%D0%BD%D0%B0%D1%8F_%D1%81%D1%83%D0%B2%D1%8F%D0%B7%D1%8C" title="Пептыдная сувязь - bielorusso" lang="be" hreflang="be" data-title="Пептыдная сувязь" data-language-autonym="Беларуская" data-language-local-name="bielorusso" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%9F%D0%B5%D0%BF%D1%82%D0%B8%D0%B4%D0%BD%D0%B0_%D0%B2%D1%80%D1%8A%D0%B7%D0%BA%D0%B0" title="Пептидна връзка - bulgaro" lang="bg" hreflang="bg" data-title="Пептидна връзка" data-language-autonym="Български" data-language-local-name="bulgaro" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%AA%E0%A7%87%E0%A6%AA%E0%A6%9F%E0%A6%BE%E0%A6%87%E0%A6%A1_%E0%A6%AC%E0%A6%A8%E0%A7%8D%E0%A6%A7%E0%A6%A8" title="পেপটাইড বন্ধন - bengalese" lang="bn" hreflang="bn" data-title="পেপটাইড বন্ধন" data-language-autonym="বাংলা" data-language-local-name="bengalese" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Peptidna_veza" title="Peptidna veza - bosniaco" lang="bs" hreflang="bs" data-title="Peptidna veza" data-language-autonym="Bosanski" data-language-local-name="bosniaco" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Enlla%C3%A7_pept%C3%ADdic" title="Enllaç peptídic - catalano" lang="ca" hreflang="ca" data-title="Enllaç peptídic" data-language-autonym="Català" data-language-local-name="catalano" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Peptidov%C3%A1_vazba" title="Peptidová vazba - ceco" lang="cs" hreflang="cs" data-title="Peptidová vazba" data-language-autonym="Čeština" data-language-local-name="ceco" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Peptidbinding" title="Peptidbinding - danese" lang="da" hreflang="da" data-title="Peptidbinding" data-language-autonym="Dansk" data-language-local-name="danese" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Peptidbindung" title="Peptidbindung - tedesco" lang="de" hreflang="de" data-title="Peptidbindung" data-language-autonym="Deutsch" data-language-local-name="tedesco" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%A0%CE%B5%CF%80%CF%84%CE%B9%CE%B4%CE%B9%CE%BA%CF%8C%CF%82_%CE%B4%CE%B5%CF%83%CE%BC%CF%8C%CF%82" title="Πεπτιδικός δεσμός - greco" lang="el" hreflang="el" data-title="Πεπτιδικός δεσμός" data-language-autonym="Ελληνικά" data-language-local-name="greco" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Peptide_bond" title="Peptide bond - inglese" lang="en" hreflang="en" data-title="Peptide bond" data-language-autonym="English" data-language-local-name="inglese" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Peptida_ligilo" title="Peptida ligilo - esperanto" lang="eo" hreflang="eo" data-title="Peptida ligilo" data-language-autonym="Esperanto" data-language-local-name="esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Enlace_pept%C3%ADdico" title="Enlace peptídico - spagnolo" lang="es" hreflang="es" data-title="Enlace peptídico" data-language-autonym="Español" data-language-local-name="spagnolo" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Peptiidside" title="Peptiidside - estone" lang="et" hreflang="et" data-title="Peptiidside" data-language-autonym="Eesti" data-language-local-name="estone" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Lotura_peptidiko" title="Lotura peptidiko - basco" lang="eu" hreflang="eu" data-title="Lotura peptidiko" data-language-autonym="Euskara" data-language-local-name="basco" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%BE%DB%8C%D9%88%D9%86%D8%AF_%D9%BE%D9%BE%D8%AA%DB%8C%D8%AF%DB%8C" title="پیوند پپتیدی - persiano" lang="fa" hreflang="fa" data-title="پیوند پپتیدی" data-language-autonym="فارسی" data-language-local-name="persiano" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Peptidisidos" title="Peptidisidos - finlandese" lang="fi" hreflang="fi" data-title="Peptidisidos" data-language-autonym="Suomi" data-language-local-name="finlandese" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Liaison_peptidique" title="Liaison peptidique - francese" lang="fr" hreflang="fr" data-title="Liaison peptidique" data-language-autonym="Français" data-language-local-name="francese" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Enlace_pept%C3%ADdico" title="Enlace peptídico - galiziano" lang="gl" hreflang="gl" data-title="Enlace peptídico" data-language-autonym="Galego" data-language-local-name="galiziano" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A7%D7%A9%D7%A8_%D7%A4%D7%A4%D7%98%D7%99%D7%93%D7%99" title="קשר פפטידי - ebraico" lang="he" hreflang="he" data-title="קשר פפטידי" data-language-autonym="עברית" data-language-local-name="ebraico" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%AA%E0%A5%87%E0%A4%AA%E0%A5%8D%E0%A4%9F%E0%A4%BE%E0%A4%87%E0%A4%A1_%E0%A4%AC%E0%A4%82%E0%A4%A7" title="पेप्टाइड बंध - hindi" lang="hi" hreflang="hi" data-title="पेप्टाइड बंध" data-language-autonym="हिन्दी" data-language-local-name="hindi" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Peptidk%C3%B6t%C3%A9s" title="Peptidkötés - ungherese" lang="hu" hreflang="hu" data-title="Peptidkötés" data-language-autonym="Magyar" data-language-local-name="ungherese" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%8A%D5%A5%D5%BA%D5%BF%D5%AB%D5%A4%D5%A1%D5%B5%D5%AB%D5%B6_%D5%AF%D5%A1%D5%BA" title="Պեպտիդային կապ - armeno" lang="hy" hreflang="hy" data-title="Պեպտիդային կապ" data-language-autonym="Հայերեն" data-language-local-name="armeno" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Ikatan_peptida" title="Ikatan peptida - indonesiano" lang="id" hreflang="id" data-title="Ikatan peptida" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonesiano" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-io mw-list-item"><a href="https://io.wikipedia.org/wiki/Peptida_ligilo" title="Peptida ligilo - ido" lang="io" hreflang="io" data-title="Peptida ligilo" data-language-autonym="Ido" data-language-local-name="ido" class="interlanguage-link-target"><span>Ido</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%9A%E3%83%97%E3%83%81%E3%83%89%E7%B5%90%E5%90%88" title="ペプチド結合 - giapponese" lang="ja" hreflang="ja" data-title="ペプチド結合" data-language-autonym="日本語" data-language-local-name="giapponese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%ED%8E%A9%ED%83%80%EC%9D%B4%EB%93%9C_%EA%B2%B0%ED%95%A9" title="펩타이드 결합 - coreano" lang="ko" hreflang="ko" data-title="펩타이드 결합" data-language-autonym="한국어" data-language-local-name="coreano" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-mn mw-list-item"><a href="https://mn.wikipedia.org/wiki/%D0%9F%D0%B5%D0%BF%D1%82%D0%B8%D0%B4%D0%B8%D0%B9%D0%BD_%D1%85%D0%BE%D0%BB%D0%B1%D0%BE%D0%BE" title="Пептидийн холбоо - mongolo" lang="mn" hreflang="mn" data-title="Пептидийн холбоо" data-language-autonym="Монгол" data-language-local-name="mongolo" class="interlanguage-link-target"><span>Монгол</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Ikatan_peptida" title="Ikatan peptida - malese" lang="ms" hreflang="ms" data-title="Ikatan peptida" data-language-autonym="Bahasa Melayu" data-language-local-name="malese" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Peptidebinding" title="Peptidebinding - olandese" lang="nl" hreflang="nl" data-title="Peptidebinding" data-language-autonym="Nederlands" data-language-local-name="olandese" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Peptidbinding" title="Peptidbinding - norvegese bokmål" lang="nb" hreflang="nb" data-title="Peptidbinding" data-language-autonym="Norsk bokmål" data-language-local-name="norvegese bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Ligam_peptidic" title="Ligam peptidic - occitano" lang="oc" hreflang="oc" data-title="Ligam peptidic" data-language-autonym="Occitan" data-language-local-name="occitano" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Wi%C4%85zanie_peptydowe" title="Wiązanie peptydowe - polacco" lang="pl" hreflang="pl" data-title="Wiązanie peptydowe" data-language-autonym="Polski" data-language-local-name="polacco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Liga%C3%A7%C3%A3o_pept%C3%ADdica" title="Ligação peptídica - portoghese" lang="pt" hreflang="pt" data-title="Ligação peptídica" data-language-autonym="Português" data-language-local-name="portoghese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Leg%C4%83tur%C4%83_peptidic%C4%83" title="Legătură peptidică - rumeno" lang="ro" hreflang="ro" data-title="Legătură peptidică" data-language-autonym="Română" data-language-local-name="rumeno" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9F%D0%B5%D0%BF%D1%82%D0%B8%D0%B4%D0%BD%D0%B0%D1%8F_%D1%81%D0%B2%D1%8F%D0%B7%D1%8C" title="Пептидная связь - russo" lang="ru" hreflang="ru" data-title="Пептидная связь" data-language-autonym="Русский" data-language-local-name="russo" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Peptidna_veza" title="Peptidna veza - serbo-croato" lang="sh" hreflang="sh" data-title="Peptidna veza" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croato" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Peptide_bond" title="Peptide bond - Simple English" lang="en-simple" hreflang="en-simple" data-title="Peptide bond" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Peptidov%C3%A1_v%C3%A4zba" title="Peptidová väzba - slovacco" lang="sk" hreflang="sk" data-title="Peptidová väzba" data-language-autonym="Slovenčina" data-language-local-name="slovacco" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Peptidna_vez" title="Peptidna vez - sloveno" lang="sl" hreflang="sl" data-title="Peptidna vez" data-language-autonym="Slovenščina" data-language-local-name="sloveno" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Peptidna_veza" title="Peptidna veza - serbo" lang="sr" hreflang="sr" data-title="Peptidna veza" data-language-autonym="Српски / srpski" data-language-local-name="serbo" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Peptidbindning" title="Peptidbindning - svedese" lang="sv" hreflang="sv" data-title="Peptidbindning" data-language-autonym="Svenska" data-language-local-name="svedese" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%AA%E0%AF%86%E0%AE%AA%E0%AF%8D%E0%AE%9F%E0%AF%88%E0%AE%9F%E0%AF%81_%E0%AE%AA%E0%AE%BF%E0%AE%A3%E0%AF%88%E0%AE%AA%E0%AF%8D%E0%AE%AA%E0%AF%81" title="பெப்டைடு பிணைப்பு - tamil" lang="ta" hreflang="ta" data-title="பெப்டைடு பிணைப்பு" data-language-autonym="தமிழ்" data-language-local-name="tamil" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%9E%E0%B8%B1%E0%B8%99%E0%B8%98%E0%B8%B0%E0%B9%80%E0%B8%9E%E0%B8%9B%E0%B9%84%E0%B8%97%E0%B8%94%E0%B9%8C" title="พันธะเพปไทด์ - thailandese" lang="th" hreflang="th" data-title="พันธะเพปไทด์" data-language-autonym="ไทย" data-language-local-name="thailandese" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Peptit_ba%C4%9F%C4%B1" title="Peptit bağı - turco" lang="tr" hreflang="tr" 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dati [g]" accesskey="g"><span>Elemento Wikidata</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Strumenti pagine"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Aspetto"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Aspetto</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">sposta nella barra laterale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">nascondi</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Da Wikipedia, l'enciclopedia libera.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="it" dir="ltr"><p>Il <b>legame peptidico</b> (o <b>giunto peptidico</b>) è il <a href="/wiki/Legame_chimico" title="Legame chimico">legame chimico</a> responsabile dell'unione degli <a href="/wiki/Amminoacido" title="Amminoacido">amminoacidi</a> e della conseguente formazione di <a href="/wiki/Peptidi" class="mw-redirect" title="Peptidi">peptidi</a> e <a href="/wiki/Proteina" class="mw-redirect" title="Proteina">proteine</a>. Si tratta di un legame di tipo <a href="/wiki/Legame_covalente" title="Legame covalente">covalente</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Sintesi">Sintesi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Legame_peptidico&veaction=edit&section=1" title="Modifica la sezione Sintesi" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Legame_peptidico&action=edit&section=1" title="Edit section's source code: Sintesi"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Quando due amminoacidi formano un dipeptide attraverso un legame peptidico, il tipo di reazione è di condensazione. In questo tipo di condensazione, due amminoacidi si avvicinano l'un l'altro, con la parte di acido carbossilico della catena non laterale (C1) di uno che si avvicina all'ammino gruppo della catena non-laterale (N2) dell'altro. Uno perde un atomo d’idrogeno ed uno di ossigeno dal suo gruppo carbossilico (COOH) e l'altro invece perde un atomo di idrogeno dal suo gruppo amminico (NH2). Questa reazione produce una molecola di acqua (H2O) e due amminoacidi uniti da un legame peptidico (-CO-NH-). L’amminoacido risultante, frutto dell’unione dei due attraverso la reazione di condensazione, viene per l’appunto chiamato dipeptide. </p><p>Il legame ammidico viene sintetizzato quando il gruppo carbossilico di una molecola di amminoacido reagisce con il gruppo amminico dell'altra molecola di amminoacido, provocando il rilascio di una molecola di acqua (H2O), quindi il processo è una reazione di sintesi di disidratazione. La formazione del legame peptidico consuma energia, che, negli organismi, è derivata dall'ATP. I peptidi e le proteine sono catene di amminoacidi tenuti insieme da legami peptidici (e talvolta da alcuni legami isopeptidici). Gli organismi usano gli enzimi per produrre peptidi nonribosomali, e ribosomi per produrre proteine attraverso reazioni che differiscono nei dettagli dalla sintesi di disidratazione. </p><p>Alcuni peptidi, come l'alfa-amanitina, sono chiamati peptidi ribosomali poiché sono prodotti sui ribosomi, ma molti sono peptidi nonribosomali in quanto sono sintetizzati da enzimi specializzati piuttosto che da ribosomi. Ad esempio, il tripeptide glutatione viene sintetizzato in due passaggi da aminoacidi liberi, da due enzimi: glutammato-cisteina ligasi (forma un legame isopeptidico, che non è un legame peptidico) e glutatione sintetasi (forma un legame peptidico). </p> <div class="mw-heading mw-heading2"><h2 id="Struttura">Struttura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Legame_peptidico&veaction=edit&section=2" title="Modifica la sezione Struttura" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Legame_peptidico&action=edit&section=2" title="Edit section's source code: Struttura"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Nuovo-33.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Nuovo-33.png/220px-Nuovo-33.png" decoding="async" width="220" height="118" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Nuovo-33.png/330px-Nuovo-33.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Nuovo-33.png/440px-Nuovo-33.png 2x" data-file-width="611" data-file-height="327" /></a><figcaption>Formazione di un dipeptide da due amminoacidi</figcaption></figure> <p>Il legame peptidico si genera nel momento in cui, tramite una <a href="/wiki/Reazione_di_condensazione" title="Reazione di condensazione">reazione di condensazione</a> (ovvero l'unione di due strutture molecolari con la perdita di una molecola di H<sub>2</sub>O), la parte <a href="/wiki/Acido" title="Acido">acida</a> di un amminoacido (il gruppo funzionale carbossilico -COOH) si unisce con quella <a href="/wiki/Base_(chimica)" title="Base (chimica)">basica</a> di un altro amminoacido (il <a href="/wiki/Gruppo_funzionale" title="Gruppo funzionale">gruppo funzionale</a> amminico -NH<sub>2</sub>). Quando ciò avviene, uno degli idrogeni (H<sup>+</sup>) legati all'<a href="/wiki/Azoto" title="Azoto">azoto</a> si separa e si unisce al gruppo OH<sup>-</sup> legato al <a href="/wiki/Carbonio" title="Carbonio">carbonio</a> formando una molecola d'acqua e permettendo a C e ad N di unirsi con un legame detto appunto peptidico. </p><p>Siccome un dipeptide (ovvero una molecola che possiede un solo legame peptidico tra due amminoacidi) comprende ancora nella sua molecola sia un gruppo amminico che uno carbossilico, esso può nuovamente allungarsi in seguito ad altre condensazioni dando luogo ad un polipeptide. Per convenzione, questo viene detto "proteina" quando il numero di residui di amminoacidi legati supera 20 o 30, a seconda delle fonti. </p><p>Il legame peptidico non è un legame singolo perché i legami C-N e C=O sono rappresentazioni approssimate dell'effettiva struttura reale. Il legame C-N è un legame di ordine intermedio (1,32 Å) fra singolo (1,49 Å) e doppio (1,27 Å), pertanto non è possibile una rotazione libera attorno ad esso; tuttavia ciò non vale per i restanti legami, il cui movimento libero garantisce la formazione di conformazioni steriche caratteristiche. Tale legame risulta, inoltre, essere planare e particolarmente forte in virtù di una delocalizzazione della carica fra gli atomi di <a href="/wiki/Carbonio" title="Carbonio">carbonio</a> e <a href="/wiki/Azoto" title="Azoto">azoto</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>Si noti che nella condensazione tra C ed N terminale, a differenza di come mostrato in figura, l'idrogeno legato all'azoto e l'ossigeno del gruppo C=O si pongono in posizione <i>trans</i> rispetto al legame C-N (e non in posizione <i>cis</i> come mostrato nell'illustrazione). Questo determina la conformazione spaziale della molecola appena formata. </p> <div class="mw-heading mw-heading2"><h2 id="Idrolisi_del_legame_peptidico">Idrolisi del legame peptidico</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Legame_peptidico&veaction=edit&section=3" title="Modifica la sezione Idrolisi del legame peptidico" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Legame_peptidico&action=edit&section=3" title="Edit section's source code: Idrolisi del legame peptidico"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>L'<a href="/wiki/Idrolisi" title="Idrolisi">idrolisi</a> <a href="/wiki/Enzima" title="Enzima">enzimatica</a> è la reazione più semplice per rompere un legame covalente peptidico. Essa consiste nella reazione inversa alla condensazione: con l'aggiunta di acqua e l'azione di un enzima si passa dai prodotti ai reagenti, quindi, nel caso di un dipeptide, ai due amminoacidi separati. Questa reazione è sfruttata nell'<a href="/wiki/Apparato_digerente" title="Apparato digerente">apparato digerente</a> in cui esistono, a più livelli, numerosi <a href="/wiki/Proteasi" title="Proteasi">enzimi proteolitici</a> (<a href="/wiki/Pepsina" title="Pepsina">pepsina</a>, <a href="/wiki/Chimotripsina" title="Chimotripsina">chimotripsina</a>, <a href="/wiki/Tripsina" title="Tripsina">tripsina</a>, ecc.) per tramutare le proteine ingerite con l'alimentazione negli <a href="/wiki/Amminoacidi" class="mw-redirect" title="Amminoacidi">amminoacidi</a> che vengono quindi assorbiti dalle cellule epiteliali intestinali prima di essere trasferiti nel circolo sanguigno per le necessità dell'organismo. </p> <div class="mw-heading mw-heading2"><h2 id="Note">Note</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Legame_peptidico&veaction=edit&section=4" title="Modifica la sezione Note" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Legame_peptidico&action=edit&section=4" title="Edit section's source code: Note"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><a href="#cite_ref-1"><b>^</b></a> <span class="reference-text"><cite class="citation libro" style="font-style:normal"> <span style="font-style:italic;">Biochimica Medica - Siliprandi & Tettamanti</span>, Piccin, p. 49.</cite></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Voci_correlate">Voci correlate</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Legame_peptidico&veaction=edit&section=5" title="Modifica la sezione Voci correlate" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Legame_peptidico&action=edit&section=5" title="Edit section's source code: Voci correlate"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Peptide" title="Peptide">Peptide</a></li> <li><a href="/wiki/Proteina" class="mw-redirect" title="Proteina">Proteina</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Altri_progetti">Altri progetti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Legame_peptidico&veaction=edit&section=6" title="Modifica la sezione Altri progetti" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Legame_peptidico&action=edit&section=6" title="Edit section's source code: Altri progetti"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div id="interProject" class="toccolours" style="display: none; clear: both; margin-top: 2em"><p id="sisterProjects" style="background-color: #efefef; color: black; font-weight: bold; margin: 0"><span>Altri progetti</span></p><ul title="Collegamenti verso gli altri progetti Wikimedia"> <li class="" title=""><a href="https://it.wiktionary.org/wiki/legame_peptidico" class="extiw" title="wikt:legame peptidico">Wikizionario</a></li> <li class="" title=""><span class="plainlinks" title="commons:Category:Peptide bond"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Peptide_bond?uselang=it">Wikimedia Commons</a></span></li></ul></div> <ul><li><span typeof="mw:File"><a href="https://it.wiktionary.org/wiki/" title="Collabora a Wikizionario"><img alt="Collabora a Wikizionario" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Wiktionary_small.svg/18px-Wiktionary_small.svg.png" decoding="async" width="18" height="18" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Wiktionary_small.svg/27px-Wiktionary_small.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Wiktionary_small.svg/36px-Wiktionary_small.svg.png 2x" data-file-width="350" data-file-height="350" /></a></span> <a href="https://it.wiktionary.org/wiki/" class="extiw" title="wikt:">Wikizionario</a> contiene il lemma di dizionario «<b><a href="https://it.wiktionary.org/wiki/legame_peptidico" class="extiw" title="wikt:legame peptidico">legame peptidico</a></b>»</li> <li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/?uselang=it" title="Collabora a Wikimedia Commons"><img alt="Collabora a Wikimedia Commons" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png" decoding="async" width="18" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/27px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/36px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/?uselang=it">Wikimedia Commons</a></span> contiene immagini o altri file sul <b><span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Peptide_bond?uselang=it">legame peptidico</a></span></b></li></ul> <div class="mw-heading mw-heading2"><h2 id="Collegamenti_esterni">Collegamenti esterni</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Legame_peptidico&veaction=edit&section=7" title="Modifica la sezione Collegamenti esterni" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Legame_peptidico&action=edit&section=7" title="Edit section's source code: Collegamenti esterni"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li class="mw-empty-elt"></li> <li><cite id="CITEREFBritannica.com" class="citation web" style="font-style:normal">(<span style="font-weight:bolder; font-size:80%"><abbr title="inglese">EN</abbr></span>) <a rel="nofollow" class="external text" href="https://www.britannica.com/science/peptide-bond"><span style="font-style:italic;">peptide bond</span></a>, su <span style="font-style:italic;"><a href="/wiki/Enciclopedia_Britannica" title="Enciclopedia Britannica">Enciclopedia Britannica</a></span>, Encyclopædia Britannica, Inc.</cite> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q33293#P1417" title="Modifica su Wikidata"><img alt="Modifica su Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></li></ul> <style data-mw-deduplicate="TemplateStyles:r140554510">.mw-parser-output .CdA{border:1px solid #aaa;width:100%;margin:auto;font-size:90%;padding:2px}.mw-parser-output .CdA th{background-color:#f2f2f2;font-weight:bold;width:20%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .CdA{border-color:#54595D}html.skin-theme-clientpref-night .mw-parser-output .CdA th{background-color:#202122}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .CdA{border-color:#54595D}html.skin-theme-clientpref-os .mw-parser-output .CdA th{background-color:#202122}}</style><table class="CdA"><tbody><tr><th><a href="/wiki/Aiuto:Controllo_di_autorit%C3%A0" title="Aiuto:Controllo di autorità">Controllo di autorità</a></th><td><a href="/wiki/Gemeinsame_Normdatei" title="Gemeinsame Normdatei">GND</a> <span class="uid">(<span style="font-weight:bolder; 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