S-adenosyl-L-methionine, trehalose and oleanolic acid in few plants

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Unlock the benefits of AdoMet, trehalose, and oleanolic acid for optimal health." /> <meta name="citation_journal_title" content="Health" /> <meta name="citation_publisher" content="Scientific Research Publishing" /> <meta name="citation_authors" content="Dipankar Malakar;Paramita Chaudhuri;Trina Dutta;Anil K Ghosh" /> <meta name="citation_author" content="Dipankar Malakar" /> <meta name="citation_author" content="Paramita Chaudhuri" /> <meta name="citation_author" content="Trina Dutta" /> <meta name="citation_author" content="Anil K Ghosh" /> <meta name="citation_title" content="S-adenosyl-L-methionine, trehalose and oleanolic acid in few plants" /> <meta name="citation_volume" content="2" /> <meta name="citation_date" content="2010-08-25" /> <meta name="citation_year" content="2010" /> <meta name="citation_doi" content="10.4236/health.2010.28144" /> <meta name="citation_issnPrint" content="1949-4998" /> <meta name="citation_issnOnline" content="1949-5005" /> <meta name="citation_abstract" content="S-Adenosyl-L-Methionine (AdoMet), S-Adenosyl- L-Homocysteine (AdoHcy), adenosine, trehalose and oleanolic acid were measured in six medicinal herbs and three spices. The findings showed that AdoMet content was forty six fold higher in the leaves of Catharanthus roseus as compared with average AdoMet content of rest of the plants. In comparison to other plants, Withania somnifera had very high AdoHcy: Ado-Met and adenosine: AdoMet ratios indicating it may have contained high AdoMet. Trehalose was found to be twenty fold and nine fold higher in bulb of Allium cepa and root of Withania somnifera respectively with respect to average trehalose content of rest of the plants. Ocimum sanctum appeared to be a rich source of oleanolic acid. It appeared from our study that Catharanthus roseus, Allium cepa and Ocimum sanctum could be utilized as natural sources of AdoMet, trehalose and oleanolic acid respectively." /> <meta name="citation_publication_date" content="2010/8/25" /> <meta name="citation_pdf_url" content="https://www.scirp.org/pdf/Health20100800022_16877525.pdf" /> <meta name="fulltext_pdf" content="https://www.scirp.org/pdf/Health20100800022_16877525.pdf" /> <meta name="citation_abstract_html_url" content="https://www.scirp.org/journal/paperabs?paperid=2471" /> <meta name="citation_fulltext_html_url" content="https://www.scirp.org/html/2471.html" /> <meta name="fulltext_html" content="https://www.scirp.org/html/2471.html" /> <meta name="citation_issue" content="8" /> <meta name="citation_online_date" content="2010/8/25" /> <meta name="citation_firstpage" content="968" /> <meta name="citation_lastpage" content="972" /> <meta name="dc.title" content="S-adenosyl-L-methionine, trehalose and oleanolic acid in few plants" /> <meta name="dc.creator" content="Dipankar Malakar" /> <meta name="dc.creator" content="Paramita Chaudhuri" /> <meta name="dc.creator" content="Trina Dutta" /> <meta name="dc.creator" content="Anil K Ghosh" /><meta name="dcterms.issued" content="2010-08-25" /> <meta name="dc.description" content="S-Adenosyl-L-Methionine (AdoMet), S-Adenosyl- L-Homocysteine (AdoHcy), adenosine, trehalose and oleanolic acid were measured in six medicinal herbs and three spices. The findings showed that AdoMet content was forty six fold higher in the leaves of Catharanthus roseus as compared with average AdoMet content of rest of the plants. In comparison to other plants, Withania somnifera had very high AdoHcy: Ado-Met and adenosine: AdoMet ratios indicating it may have contained high AdoMet. Trehalose was found to be twenty fold and nine fold higher in bulb of Allium cepa and root of Withania somnifera respectively with respect to average trehalose content of rest of the plants. Ocimum sanctum appeared to be a rich source of oleanolic acid. It appeared from our study that Catharanthus roseus, Allium cepa and Ocimum sanctum could be utilized as natural sources of AdoMet, trehalose and oleanolic acid respectively." /> <meta name="dc.source" content="Health" /> <meta name="dc.format" content="text/html" /> <meta name="dc.publisher" content="Scientific Research Publishing" /> <meta name="dc.date" content="2010-08-25" /> <meta name="dc.type" content="Article" /> <meta name="dc.identifier" content="doi:10.4236/health.2010.28144" /> <meta name="dc.language" content="en" /> <meta name="dc.issued" content="2010-08-25" /> <meta name="prism.issnPrint" content="1949-4998" /> <meta name="prism.issnOnline" content="1949-5005" /> <meta name="prism.publicationName" content="Health" /> <meta name="prism.publicationDate" content="2010-08-25" /> <meta name="prism.volume" content="2" /> <meta name="prism.number" content="8" /> <meta name="prism.section" content="Article" /> <meta name="prism.startingPage" content="968" /> <meta name="prism.doi" content="10.4236/health.2010.28144" /> <meta name="Author" content="Scientific Research Publishing" /> <meta name="dc.rights" scheme="DCTERMS.URI" content="http://creativecommons.org/licenses/by/4.0/" /> <meta name="dc.rights" content="(c) 2015 by author(s) and Scientific Research Publishing Inc." /></head> <body> <form method="post" action="./paperinformation?paperid=2471" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" 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style="margin-bottom: 10px; padding-left: 15px; padding-right: 15px;"> <div id="JournalInfor_div_nav_journal" class="column up_link1 clearfix" style="padding: 0;"> <div class="col-md-9 col-sm-8 txt7"> <a href="journalarticles?journalid=65" title="Health"> Health</a> > <a href="home?issueid=368#2471">Vol.2 No.8, August 2010</a> </div> </div> <div id="JournalInfor_div_paper" class="articles_main"> <div class="art_title" style="text-align:left;"> S-adenosyl-L-methionine, trehalose and oleanolic acid in few plants <span id="JournalInfor_reviewpaper_show" style="color:gray;font-weight:normal;Display:None;">()</span> </div> <div style="float: left; width: 100%; margin-top: 5px; margin-bottom: 10px;"> <a href='articles?searchcode=Dipankar++Malakar&searchfield=authors&page=1' target='_blank'>Dipankar Malakar</a>, <a href='articles?searchcode=Paramita++Chaudhuri&searchfield=authors&page=1' target='_blank'>Paramita Chaudhuri</a>, <a href='articles?searchcode=Trina++Dutta&searchfield=authors&page=1' target='_blank'>Trina Dutta</a>, <a href='articles?searchcode=Anil+K++Ghosh&searchfield=authors&page=1' target='_blank'>Anil K Ghosh</a> <br /> <span id="JournalInfor_showDOI" style="clear: left;"><b>DOI: </b><a href="http://dx.doi.org/10.4236/health.2010.28144" target="_blank" onclick='SetNum(2471)'>10.4236/health.2010.28144</a></span>   <a href="//www.scirp.org/pdf/Health20100800022_16877525.pdf" target="_blank" style="font-size: 14px; font-weight: bold;" onclick='SetNum(2471)'> PDF</a>    <span style="font-size: 14px; font-weight: bold;"><a href='//www.scirp.org/html/2471.html' target='_blank'>HTML</a></span>  <span style="font-size: 14px; font-weight: bold;"></span>   <span style="font-weight: bold; color: Red;"> 4,782</span> <span style="color: #535353;">Downloads</span>  <span style="font-weight: bold; color: Red;"> 9,337</span> <span style="color: #535353;">Views</span>   <span id="JournalInfor_span_citations" style="Display:None;"><a href='papercitationdetails?paperid=2471&JournalID=65' target="_blank"><span style="text-decoration: underline;">Citations</span></a></span> </div> <div style="margin-bottom: 10px;"> <p style="font-weight: bold; font-size: 16px;"><a name="abstract" style="color: #2f2f2f;">Abstract</a></p> <p style="text-align:left;">S-Adenosyl-L-Methionine (AdoMet), S-Adenosyl- L-Homocysteine (AdoHcy), adenosine, trehalose and oleanolic acid were measured in six medicinal herbs and three spices. The findings showed that AdoMet content was forty six fold higher in the leaves of Catharanthus roseus as compared with average AdoMet content of rest of the plants. In comparison to other plants, Withania somnifera had very high AdoHcy: Ado-Met and adenosine: AdoMet ratios indicating it may have contained high AdoMet. Trehalose was found to be twenty fold and nine fold higher in bulb of Allium cepa and root of Withania somnifera respectively with respect to average trehalose content of rest of the plants. Ocimum sanctum appeared to be a rich source of oleanolic acid. It appeared from our study that Catharanthus roseus, Allium cepa and Ocimum sanctum could be utilized as natural sources of AdoMet, trehalose and oleanolic acid respectively.</p> </div> <div id="JournalInfor_div_showkeywords" style="margin-bottom: 10px;"> <p style="font-weight: bold; font-size: 16px;">Keywords</p> <p><a href='articles?searchcode=AdoMet%3b+AdoHcy%3b+Adenosine%3b+Trehalose%3b+Oleanolic+Acid&searchfield=keyword&page=1' target='_blank'>AdoMet; AdoHcy; Adenosine; Trehalose; Oleanolic Acid</a> </p> </div> <div style="margin-bottom: 10px;"> <p style="font-size: 16px; font-weight: bold;">Share and Cite: </p> <div id="JournalInfor_div_share">  <div class="a2a_kit a2a_kit_size_32 a2a_default_style"> <a class="a2a_button_facebook"></a> <a class="a2a_button_twitter"></a> <a class="a2a_button_linkedin"></a> <a class="a2a_button_sina_weibo"></a> <a class="a2a_dd" href="https://www.addtoany.com/share"></a> </div> <script type="text/javascript" async src="https://static.addtoany.com/menu/page.js"></script>  </div> <div style="margin-top: 10px; text-align:left;"> Malakar, D. , Chaudhuri, P. , Dutta, T. and Ghosh, A. (2010) S-adenosyl-L-methionine, trehalose and oleanolic acid in few plants. <i>Health</i>, <b>2</b>, 968-972. doi: <a href='http://dx.doi.org/10.4236/health.2010.28144' target='_blank' onclick='SetNum(2471)'>10.4236/health.2010.28144</a>. </div> </div> <div style="margin-top:10px;" id="htmlContent"> </div> <div style="margin-top: 10px;"> <p style="font-size: 16px; font-weight: bold;">Conflicts of Interest</p> <p style="text-align: justify;">The authors declare no conflicts of interest.</p> </div> <div style="margin-top: 10px;"> <p style="font-size: 16px; font-weight: bold;"> <a name="reference" style="color: #2f2f2f;">References</a> </p> <p> <table width="100%" border="0" cellspacing="0" cellpadding="0" style="text-align: left; word-break: break-word; "> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50608' target='_blank'>1</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref1" id="ref1"></a> Lu, S.C. (2000) S-Adenosylmethionine. The Interna-tional Journal of Biochemistry & Cell Biology, 32(4), 391-395. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50609' target='_blank'>2</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref2" id="ref2"></a> Fernandez-Checa, J.C., Colell, A. and Garcia-Ruiz, C. (2002) S-Adenosyl-L-methionine and mitochondrial re-duced glutathione depletion in alcoholic liver disease. Alcohol, 27(3), 179-183. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50610' target='_blank'>3</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref3" id="ref3"></a> Turchetti, V., Bellini, M.A., Leoncini, F., Petri, F., Tra-balzini, L., Guerrini, M. and Forconi, S. (2000) Blood viscosity and red cell morphology in subjects suffering from cirrhosis before and treatment with S-adenosyl-L- methionine (SAM). Clinical Hemorheology and Micro-circulation, 22(3), 215-221. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50611' target='_blank'>4</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref4" id="ref4"></a> Mischoulon, D. and Fava, M. (2002) Role of S-adenosyl- L-methionine in the treatment of depression: A review of the evidence. American Journal of Clinical Nutrition, 76(5), 11585-11615. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50612' target='_blank'>5</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref5" id="ref5"></a> Fuso, A., Seminara, L., Cavallaro, R.A., D'Anselmi, F. and Scarpa, S. (2005) S-adenosylmethionine/homocys-teine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Molecular and Cellular Neu-roscience, 28(1), 195-204. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50613' target='_blank'>6</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref6" id="ref6"></a> Najm, W.I., Reinsch, S., Hoehler, F., Tobis, J.S. and Har-vey, P.W. (2004) S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. BMC Musculoskeletal Dis-orders, 5(1), 6. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50614' target='_blank'>7</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref7" id="ref7"></a> Kaushik, J.K. and Bhat, R. (2003) Why Is trehalose an Exceptional Protein Stabilizer? An analysis of the ther-mal stability of proteins in the presence of the compatible osmolyte trehalose. Journal of Biological Chemistry, 278(29), 26458-26465. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50615' target='_blank'>8</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref8" id="ref8"></a> Morana, A., Stiuso, P., Colonna, G., Lamberti, M., Carten, M. and De Rosa, M. (2002) Stabilization of S-adenosyl- L-methionine promoted by trehalose. Biochimica et Bio-physica Acta, 1573(2), 105-108. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50616' target='_blank'>9</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref9" id="ref9"></a> Limaye, L.S. and Kale, V.P. (2001) Cryopreservation of human hematopoietic cells with membrane stabilizers and bioantioxidants as additives in the conventional freezing medium. Journal of Hematotherapy and Stem Cell Research, 10(5), 709-718. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50617' target='_blank'>10</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref10" id="ref10"></a> Liu, J. (1995) Pharmacology of oleanolic acid and ursolic acid. Journal of Ethnopharmacology, 49(2), 57-68. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50618' target='_blank'>11</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref11" id="ref11"></a> Giner-Larza, E.M., Manez, S., Recio, M.C., Giner, R.M., Prieto, J.M., Cerda-Nicolas, M. and Rios, J.L. (2001) Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. European Journal of Pharmacology, 428(1), 137-143. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50619' target='_blank'>12</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref12" id="ref12"></a> Hsu, H.Y., Yang, J.J. and Lin, C.C. (1997) Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. Cancer Letter, 111(1-2), 7-13. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50620' target='_blank'>13</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref13" id="ref13"></a> Ubaid, R.S., Anantrao, K.M., Jaju, J.B. and Mateenuddin, M. (2003) Effect of Ocimum sanctum (OS) leaf extract on hepatotoxicity induced by antitubercular drugs in rats. Indian. Journal of Physiology and Pharmacology, 47(4), 465-470. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50621' target='_blank'>14</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref14" id="ref14"></a> Singh, S.S., Pandey, S.C., Srivastava, S., Gupta, V.S., Patro, B. and Ghosh, A.C. (2003) Chemistry and me-dicinal properties of Tinospora cordifolia (guduchi). In-dian Journal of Pharmacology, 35(2), 83-91. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50622' target='_blank'>15</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref15" id="ref15"></a> Thyagarajan, S., Jayaram, S., Gopalakrishnan, V., Hari, R., Jeyakumar, P. and Sripathi, M. (2002) Herbal medi-cines for liver diseases in India. Journal of Gastroenterol-ogy and Hepatology, 17(S3), S370- S376. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50623' target='_blank'>16</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref16" id="ref16"></a> Akbarsha, M.A., Vijendrakumar, S., Kadalmani, B., Girija, R. and Faridha, A. (2000) Curative property of Withania somnifera Dunal root in the context of carben-dazim-induced histopathological changes in the liver and kidney of rat. Phytomedicine, 7(6), 499-507. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50624' target='_blank'>17</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref17" id="ref17"></a> Bhattacharyya, D., Mukherjee, R., Pandit, S., Das, N. and Sur, T.K. (2003) Prevention of carbon tetrachloride in-duced hepatotoxicity in rats by himoliv, a polyherbal formulation. Indian Journal of Pharmacology, 35(3), 183-185. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50625' target='_blank'>18</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref18" id="ref18"></a> Balasenthil, S. and Nagini, S. (2000) Garlic exerts hepa- toprotective effects during 4-nitroquinoline 1-oxide- induced oral carcinogenesis in rats. Asia Pacific Journal of Clinical Nutrition, 9(2), 136-138. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50626' target='_blank'>19</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref19" id="ref19"></a> Al-Yahya, M.A., Rafatullah, S., Mossa, J.S., Ageel, A.M., Parmar, N.S. and Tariq, M. (1989) Gastroprotective ac-tivity of ginger zingiber officinale rosc in albino rats. American Journal of Chinese Medicine, 17(1-2), 51-66. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50627' target='_blank'>20</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref20" id="ref20"></a> Zheng, W.Z. and Wang, S.Y. (2001) Antioxidant Activity and Phenolic Compounds in Selected Herbs. Journal of Agricultural and Food Chemistry, 49(11), 5165-5170. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50628' target='_blank'>21</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref21" id="ref21"></a> Sutherland, I.W. and Wilkinson, J.F. (1971) Chemical extraction methods of microbial cells. Methods in Micro-biology, 5(Part 2), 345-383. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50629' target='_blank'>22</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref22" id="ref22"></a> Hoffman, J.L. (1986) Chromatographic analysis of the chiral and covalent instability of S-adenosyl-L-methionine. Biochemistry, 25(15), 4444-4449. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50630' target='_blank'>23</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref23" id="ref23"></a> Bhattacharyya, S., Chaudhuri, P., Basu, A. and Ghosh, A.K. (2005) Regulation of trehalose metabolism by Adox and AdoMet in Saccharomyces cerevisiae. Indian Jour-nal of Experimental Biology, 43(4), 360-368. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50631' target='_blank'>24</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref24" id="ref24"></a> Biswas, N. and Ghosh, A.K. (1996) Characterisation of an acid trehalase of Saccharomyces cerevisiae present in trehalase-sucrase aggregate. Biochimica et Biophysica Acta, 1290(1), 95-100. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50632' target='_blank'>25</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref25" id="ref25"></a> Baricevic, D., Sosa, S., Loggia, R.D., Tubaro, A., Si-monovska, B., Krasna, A. and Zupancic (2001) A Topical anti-inflammatory activity of Salvia officinalis L. leaves: The relevance of ursolic acid. Journal of Ethnopharma-cology, 75(2), 125-132. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50633' target='_blank'>26</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref26" id="ref26"></a> Dutta, A., Batra, J., Pandey-Rai, S., Singh, D., Kumar, S. and Sen, J. (2005) Expression of terpenoid indole alka-loid biosynthetic pathway genes corresponds to accumu-lation of related alkaloids in Catharanthus roseus (L.) G. Don. Planta, 220(3), 376-383. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50634' target='_blank'>27</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref27" id="ref27"></a> Mincheva, K.P. and Balutsov, V.M. (2002) Isolation of a Kluyveromyces lactis Mutant Enriched in S-Adenosyl-L- Methionine and Growing in Whey Medium. Applied Biochemistry and Microbiology, 38(4), 335-338. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50635' target='_blank'>28</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref28" id="ref28"></a> Savova, I., Donev, T. and Sholeva, Z. (1998) An investi-gation of the trehalose accumulation dynamics by yeasts from genus Saccharomyces. Journal of Culture Collections, 2(1), 40-43. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50636' target='_blank'>29</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref29" id="ref29"></a> Clegg, J.S. and Filosa, M.F. (1961) Trehalose in the cel-lular slime mold, Dictysostelium mucoroides. Nature, 192(4807), 1077-1078. </td> </tr> <tr> <td width="45" valign="top"> [<a href='../reference/referencespapers?referenceid=50637' target='_blank'>30</a>] </td> <td valign="top" style="word-wrap:break-word; "> <a target="_self" name="ref30" id="ref30"></a> Sussman, A.S. and Lingappa, B.T. (1959) Role of treha-lose in ascospores of Neurospora tetrasperma. 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S-adenosyl-L-methionine, trehalose and oleanolic acid in few plants