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class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CYP2B6</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P12791%20or%20P20813">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P12791,P20813">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3IBD">3IBD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3QOA">3QOA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3QU8">3QU8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3UA5">3UA5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4I91">4I91</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4RQL">4RQL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4RRT">4RRT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4ZV8">4ZV8</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/2615">CYP2B6</a></span>, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450, cytochrome P450 family 2 subfamily B member 6, Cytochrome P450 2B6</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/123930">123930</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:88598">88598</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=73894">73894</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP2B6">CYP2B6</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000197408">CYP2B6 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (human)"><img alt="Chromosome 19 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/300px-Ideogram_human_chromosome_19.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/450px-Ideogram_human_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/600px-Ideogram_human_chromosome_19.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_19_(human)" class="mw-redirect" title="Chromosome 19 (human)">Chromosome 19 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_19_ideogram.svg" class="mw-file-description" title="Chromosome 19 (human)"><img alt="Chromosome 19 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Human_chromosome_19_ideogram.svg/300px-Human_chromosome_19_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Human_chromosome_19_ideogram.svg/450px-Human_chromosome_19_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Human_chromosome_19_ideogram.svg/600px-Human_chromosome_19_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 200.35529384696px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CYP2B6"><img alt="Genomic location for CYP2B6" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 206.4px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CYP2B6"><img alt="Genomic location for CYP2B6" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">19q13.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">40,991,282 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">41,018,398 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (mouse)"><img alt="Chromosome 7 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/390px-Ideogram_house_mouse_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/520px-Ideogram_house_mouse_chromosome_7.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 7 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (mouse)"><img alt="Chromosome 7 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/300px-Ideogram_of_house_mouse_chromosome_7.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/450px-Ideogram_of_house_mouse_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/600px-Ideogram_of_house_mouse_chromosome_7.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 46.395453152463px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CYP2B6"><img alt="Genomic location for CYP2B6" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 52.4px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CYP2B6"><img alt="Genomic location for CYP2B6" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">7 A3|7 14.11 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">25,597,045 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">25,626,049 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000197408">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right lobe of liver</li><br /><li style="line-height: 137%;">buccal mucosa cell</li><br /><li style="line-height: 137%;">mucosa of paranasal sinus</li><br /><li style="line-height: 137%;">nasal epithelium</li><br /><li style="line-height: 137%;">kidney tubule</li><br /><li style="line-height: 137%;">tendon of biceps brachii</li><br /><li style="line-height: 137%;">mucosa of ileum</li><br /><li style="line-height: 137%;">mucosa of transverse colon</li><br /><li style="line-height: 137%;">olfactory zone of nasal mucosa</li><br /><li style="line-height: 137%;">metanephric glomerulus</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000030483">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right lung lobe</li><br /><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">lacrimal gland</li><br /><li style="line-height: 137%;">parotid gland</li><br /><li style="line-height: 137%;">submandibular gland</li><br /><li style="line-height: 137%;">intestinal villus</li><br /><li style="line-height: 137%;">skin of abdomen</li><br /><li style="line-height: 137%;">Ileal epithelium</li><br /><li style="line-height: 137%;">skin of external ear</li><br /><li style="line-height: 137%;">jejunum</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000197408">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005506">iron ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008392">arachidonic acid epoxygenase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016712">oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0020037">heme binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016705">oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016491">oxidoreductase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008395">steroid hydroxylase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004497">monooxygenase activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031090">organelle membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005789">endoplasmic reticulum membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043231">intracellular membrane-bounded organelle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005783">endoplasmic reticulum</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008202">steroid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019373">epoxygenase P450 pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042180">cellular ketone metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006805">xenobiotic metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006082">organic acid metabolic process</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=1555&rn=1">1555</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13088&rn=1">13088</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000197408;db=core">ENSG00000197408</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000030483;db=core">ENSMUSG00000030483</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P20813">P20813</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P12791">P12791</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000767">NM_000767</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009999">NM_009999</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000758">NP_000758</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks">n/a</span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr19:40991282-41018398">Chr 19: 40.99 – 41.02 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr7:25597045-25626049">Chr 7: 25.6 – 25.63 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14912267" class="extiw" title="d:Q14912267">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14912268" class="extiw" title="d:Q14912268">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Cytochrome P450 2B6</b> is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i>CYP2B6</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-entrez_5-0" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> CYP2B6 is a member of the <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> group of enzymes. Along with <a href="/wiki/CYP2A6" title="CYP2A6">CYP2A6</a>, it is involved with metabolizing <a href="/wiki/Nicotine" title="Nicotine">nicotine</a>, along with many other substances.<sup id="cite_ref-entrez_5-1" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP2B6&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are <a href="/wiki/Monooxygenase" title="Monooxygenase">monooxygenases</a> which catalyze many reactions involved in drug <a href="/wiki/Metabolism" title="Metabolism">metabolism</a> and synthesis of cholesterol, steroids and other lipids. This protein localizes to the <a href="/wiki/Endoplasmic_reticulum" title="Endoplasmic reticulum">endoplasmic reticulum</a> and its expression is induced by <a href="/wiki/Phenobarbital" title="Phenobarbital">phenobarbital</a>. The enzyme is known to metabolize some <a href="/wiki/Xenobiotic" title="Xenobiotic">xenobiotics</a>, such as the anti-cancer drugs cyclophosphamide and ifosphamide.<sup id="cite_ref-entrez_5-2" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP2B6&action=edit&section=2" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related <a href="/wiki/Pseudogene" title="Pseudogene">pseudogene</a>, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.<sup id="cite_ref-entrez_5-3" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="CYP2B6_ligands">CYP2B6 ligands</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP2B6&action=edit&section=3" title="Edit section: CYP2B6 ligands"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Following is a table of selected <a href="/wiki/Enzyme_substrate" class="mw-redirect" title="Enzyme substrate">substrates</a>, <a href="/wiki/Enzyme_induction_and_inhibition" title="Enzyme induction and inhibition">inducers</a> and <a href="/wiki/Enzyme_induction_and_inhibition" title="Enzyme induction and inhibition">inhibitors</a> of CYP2B6. </p><p>Inhibitors of CYP2B6 can be classified by their <a href="/wiki/Potency_(pharmacology)" title="Potency (pharmacology)">potency</a>, such as: </p> <ul><li><b>Strong inhibitor</b> being one that causes at least a 5-fold increase in the plasma <a href="/wiki/Area_under_the_curve_(pharmacokinetics)" title="Area under the curve (pharmacokinetics)">AUC values</a>, or more than 80% decrease in <a href="/wiki/Clearance_(medicine)" class="mw-redirect" title="Clearance (medicine)">clearance</a>.<sup id="cite_ref-:0_6-0" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li> <li><b>Moderate inhibitor</b> being one that causes at least a 2-fold increase in the plasma AUC values, or 50-80% decrease in clearance.<sup id="cite_ref-:0_6-1" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li> <li><b>Weak inhibitor</b> being one that causes at least a 1.25-fold but less than 2-fold increase in the plasma AUC values, or 20-50% decrease in clearance.<sup id="cite_ref-:0_6-2" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li></ul> <table class="wikitable" width="100%"> <tbody><tr> <th>Substrates</th> <th>Inhibitors</th> <th>Inducers </th></tr> <tr style="vertical-align: top;"> <td> <ul><li><a href="/wiki/Alfentanil" title="Alfentanil">alfentanil</a><sup id="cite_ref-FASS_7-0" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Opioid" title="Opioid">opioid</a> <a href="/wiki/Analgesic" title="Analgesic">analgesic</a>)</li> <li><a href="/wiki/Bupropion" title="Bupropion">bupropion</a><sup id="cite_ref-Flockhart_8-0" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FASS_7-1" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Antidepressant" title="Antidepressant">antidepressant</a>)</li> <li><a href="/wiki/Clopidogrel" title="Clopidogrel">clopidogrel</a><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Cyclophosphamide" title="Cyclophosphamide">cyclophosphamide</a><sup id="cite_ref-FASS_7-2" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Flockhart_8-1" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Alkylating_antineoplastic_agent" title="Alkylating antineoplastic agent">alkylating antineoplastic agent</a>)</li> <li><a href="/wiki/Efavirenz" title="Efavirenz">efavirenz</a><sup id="cite_ref-FASS_7-3" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Flockhart_8-2" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/NNRTI" class="mw-redirect" title="NNRTI">NNRTI</a>)</li> <li><a href="/wiki/Ifosfamide" title="Ifosfamide">ifosfamide</a><sup id="cite_ref-FASS_7-4" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Flockhart_8-3" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Alkylating_antineoplastic_agent" title="Alkylating antineoplastic agent">alkylating antineoplastic agent</a>)</li> <li><a href="/wiki/Ketamine" title="Ketamine">ketamine</a><sup id="cite_ref-pmid27763887_10-0" class="reference"><a href="#cite_note-pmid27763887-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Dissociative_anaesthetic" class="mw-redirect" title="Dissociative anaesthetic">dissociative anaesthetic</a>)</li> <li><a href="/wiki/Methadone" title="Methadone">methadone</a><sup id="cite_ref-Flockhart_8-4" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Opiate_replacement_therapy" class="mw-redirect" title="Opiate replacement therapy">opiate replacement therapy</a>)</li> <li><a href="/wiki/Methoxetamine" title="Methoxetamine">methoxetamine</a><sup id="cite_ref-pmid23774830_11-0" class="reference"><a href="#cite_note-pmid23774830-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Dissociative" title="Dissociative">dissociative agent</a>, <a href="/wiki/NMDA_receptor_antagonist" title="NMDA receptor antagonist">NMDA receptor antagonist</a>)</li> <li><a href="/wiki/Nevirapine" title="Nevirapine">nevirapine</a><sup id="cite_ref-FASS_7-5" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/NNRTI" class="mw-redirect" title="NNRTI">NNRTI</a>)</li> <li><a href="/wiki/Propofol" title="Propofol">propofol</a><sup id="cite_ref-FASS_7-6" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Anesthetic" title="Anesthetic">anesthetic</a>)</li> <li><a href="/wiki/Selegiline" title="Selegiline">selegiline</a><sup id="cite_ref-pmid17101742_12-0" class="reference"><a href="#cite_note-pmid17101742-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Sertraline" title="Sertraline">sertraline</a><sup id="cite_ref-pmid15547048_13-0" class="reference"><a href="#cite_note-pmid15547048-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Antidepressant" title="Antidepressant">antidepressant</a>)</li> <li><a href="/wiki/Sorafenib" title="Sorafenib">sorafenib</a><sup id="cite_ref-Flockhart_8-5" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Protein_kinase" title="Protein kinase">protein kinase</a> inhibitor)</li> <li><a href="/wiki/Tamoxifen" title="Tamoxifen">tamoxifen</a><sup id="cite_ref-FASS_7-7" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Selective_estrogen_receptor_modulator" title="Selective estrogen receptor modulator">SERM</a>)</li> <li><a href="/wiki/Valproic_acid" class="mw-redirect" title="Valproic acid">valproic acid</a><sup id="cite_ref-FASS_7-8" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Anticonvulsant" title="Anticonvulsant">anticonvulsant</a>)</li> <li><a href="/wiki/Verapamil" title="Verapamil">verapamil</a> (minor/<a href="/wiki/Moderate_sensitive_substrates" class="mw-redirect" title="Moderate sensitive substrates">moderate sensitive substrates</a>)<sup id="cite_ref-Ekins_Iyer_Krasowski_Kharasch_2008_pp._363–73_14-0" class="reference"><a href="#cite_note-Ekins_Iyer_Krasowski_Kharasch_2008_pp._363–73-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BG_Al._1997_15-0" class="reference"><a href="#cite_note-BG_Al._1997-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup></li></ul> </td> <td><b>Strong</b>: <ul><li><a href="/wiki/Orphenadrine" title="Orphenadrine">orphenadrine</a><sup id="cite_ref-FASS_7-9" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9172960_16-0" class="reference"><a href="#cite_note-pmid9172960-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Anticholinergic" title="Anticholinergic">anticholinergic</a>)</li> <li><i><a href="/wiki/Artemisia_annua" title="Artemisia annua">Artemisia annua</a></i><sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup></li></ul> <p><b>Moderate</b>: </p> <ul><li><a href="/wiki/Selegiline" title="Selegiline">selegiline</a><sup id="cite_ref-Sridar_18-0" class="reference"><a href="#cite_note-Sridar-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup></li></ul> <p><b>Unspecified potency</b> </p> <ul><li><a href="/wiki/Chlorpyrifos" title="Chlorpyrifos">chlorpyrifos</a> (<a href="/wiki/Insecticide" title="Insecticide">insecticide</a>)</li> <li><a href="/wiki/Clopidogrel" title="Clopidogrel">clopidogrel</a> (<a href="/wiki/Antiplatelet" class="mw-redirect" title="Antiplatelet">antiplatelet</a>)<sup id="cite_ref-pmid17101742_12-1" class="reference"><a href="#cite_note-pmid17101742-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Clotrimazole" title="Clotrimazole">clotrimazole</a> (<a href="/wiki/Antifungal" title="Antifungal">antifungal</a>)<sup id="cite_ref-pmid17101742_12-2" class="reference"><a href="#cite_note-pmid17101742-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Curcumin" title="Curcumin">curcumin</a> (<a href="/wiki/Dietary_supplement" title="Dietary supplement">supplement</a>)<sup id="cite_ref-pmid18480186_19-0" class="reference"><a href="#cite_note-pmid18480186-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17433521_20-0" class="reference"><a href="#cite_note-pmid17433521-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> (constituent of <a href="/wiki/Turmeric" title="Turmeric">turmeric</a>)</li> <li><a href="/wiki/Ethinylestradiol" title="Ethinylestradiol">ethinylestradiol</a> (<a href="/wiki/Estrogen_(medication)" title="Estrogen (medication)">estrogen</a>, <a href="/wiki/Hormonal_contraceptive" class="mw-redirect" title="Hormonal contraceptive">contraceptive</a>)</li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">fluoxetine</a> (<a href="/wiki/Antidepressant" title="Antidepressant">antidepressant</a>)<sup id="cite_ref-pmid10997936_21-0" class="reference"><a href="#cite_note-pmid10997936-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Fluvoxamine" title="Fluvoxamine">fluvoxamine</a> (<a href="/wiki/Antidepressant" title="Antidepressant">antidepressant</a>)<sup id="cite_ref-pmid10997936_21-1" class="reference"><a href="#cite_note-pmid10997936-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Itraconazole" title="Itraconazole">itraconazole</a> (<a href="/wiki/Antifungal" title="Antifungal">antifungal</a>)<sup id="cite_ref-pmid17101742_12-3" class="reference"><a href="#cite_note-pmid17101742-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Ketoconazole" title="Ketoconazole">ketoconazole</a> (<a href="/wiki/Antifungal" title="Antifungal">antifungal</a>)<sup id="cite_ref-pmid10997936_21-2" class="reference"><a href="#cite_note-pmid10997936-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Memantine" title="Memantine">memantine</a><sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/NMDA_antagonist" class="mw-redirect" title="NMDA antagonist">NMDA antagonist</a>)</li> <li><a href="/wiki/Paroxetine" title="Paroxetine">paroxetine</a> (<a href="/wiki/Antidepressant" title="Antidepressant">antidepressant</a>)<sup id="cite_ref-pmid10997936_21-3" class="reference"><a href="#cite_note-pmid10997936-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Raloxifene" title="Raloxifene">raloxifene</a> (<a href="/wiki/Selective_estrogen_receptor_modulator" title="Selective estrogen receptor modulator">SERM</a>)<sup id="cite_ref-pmid17101742_12-4" class="reference"><a href="#cite_note-pmid17101742-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Sertraline" title="Sertraline">sertraline</a> (<a href="/wiki/Antidepressant" title="Antidepressant">antidepressant</a>)<sup id="cite_ref-pmid17101742_12-5" class="reference"><a href="#cite_note-pmid17101742-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10997936_21-4" class="reference"><a href="#cite_note-pmid10997936-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Thiotepa" title="Thiotepa">thiotepa</a><sup id="cite_ref-Flockhart_8-6" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Anticancer" class="mw-redirect" title="Anticancer">anticancer</a>)</li> <li><a href="/wiki/Ticlopidine" title="Ticlopidine">ticlopidine</a><sup id="cite_ref-Flockhart_8-7" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Antiplatelet" class="mw-redirect" title="Antiplatelet">antiplatelet</a>)</li></ul> </td> <td> <ul><li><a href="/wiki/Carbamazepine" title="Carbamazepine">carbamazepine</a><sup id="cite_ref-FASS_7-10" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Anticonvulsant" title="Anticonvulsant">anticonvulsant</a>, <a href="/wiki/Mood_stabilizer" title="Mood stabilizer">mood stabilizer</a>)</li> <li><a href="/wiki/Phenobarbital" title="Phenobarbital">phenobarbital</a><sup id="cite_ref-Flockhart_8-8" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Anticonvulsant" title="Anticonvulsant">anticonvulsant</a>)</li> <li><a href="/wiki/Phenytoin" title="Phenytoin">phenytoin</a><sup id="cite_ref-Flockhart_8-9" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Antiepileptic" class="mw-redirect" title="Antiepileptic">antiepileptic</a>)</li> <li><a href="/wiki/Rifampicin" title="Rifampicin">rifampicin</a><sup id="cite_ref-FASS_7-11" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Flockhart_8-10" class="reference"><a href="#cite_note-Flockhart-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Bactericidal" class="mw-redirect" title="Bactericidal">bactericidal</a>)</li> <li><a href="/wiki/Efavirenz" title="Efavirenz">efavirenz</a><sup id="cite_ref-FASS_7-12" class="reference"><a href="#cite_note-FASS-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> (<a href="/wiki/Virostatic" class="mw-redirect" title="Virostatic">virostatic</a>)</li></ul> </td></tr> </tbody></table> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP2B6&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000197408">GRCh38: Ensembl release 89: ENSG00000197408</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000030483">GRCm38: Ensembl release 89: ENSMUSG00000030483</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output 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"Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products". <i>Toxicology</i>. <b>235</b> (1–2): 83–91. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2007Toxgy.235...83A">2007Toxgy.235...83A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.tox.2007.03.007">10.1016/j.tox.2007.03.007</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17433521">17433521</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Inhibition+of+human+recombinant+cytochrome+P450s+by+curcumin+and+curcumin+decomposition+products&rft.volume=235&rft.issue=1%E2%80%932&rft.pages=83-91&rft.date=2007-06&rft_id=info%3Apmid%2F17433521&rft_id=info%3Adoi%2F10.1016%2Fj.tox.2007.03.007&rft_id=info%3Abibcode%2F2007Toxgy.235...83A&rft.aulast=Appiah-Opong&rft.aufirst=R&rft.au=Commandeur%2C+JN&rft.au=van+Vugt-Lussenburg%2C+B&rft.au=Vermeulen%2C+NP&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP2B6" class="Z3988"></span></span> </li> <li id="cite_note-pmid10997936-21"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid10997936_21-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid10997936_21-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid10997936_21-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid10997936_21-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid10997936_21-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHesseVenkatakrishnanCourtvon_Moltke2000" class="citation journal cs1">Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ (October 2000). "CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants". <i>Drug Metabolism and Disposition</i>. <b>28</b> (10): 1176–83. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10997936">10997936</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=CYP2B6+mediates+the+in+vitro+hydroxylation+of+bupropion%3A+potential+drug+interactions+with+other+antidepressants&rft.volume=28&rft.issue=10&rft.pages=1176-83&rft.date=2000-10&rft_id=info%3Apmid%2F10997936&rft.aulast=Hesse&rft.aufirst=LM&rft.au=Venkatakrishnan%2C+K&rft.au=Court%2C+MH&rft.au=von+Moltke%2C+LL&rft.au=Duan%2C+SX&rft.au=Shader%2C+RI&rft.au=Greenblatt%2C+DJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP2B6" class="Z3988"></span></span> </li> <li id="cite_note-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-22">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMakinoPorsteinsson2011" class="citation journal cs1">Makino KM, Porsteinsson AP (June 2011). <a rel="nofollow" class="external text" href="http://www.medscape.com/viewarticle/748581_4">"Memantine: a treatment for Alzheimer's disease with a new formulation"</a>. <i>Aging Health</i>. <b>7</b> (3): 349–62. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2217%2Fahe.11.31">10.2217/ahe.11.31</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Aging+Health&rft.atitle=Memantine%3A+a+treatment+for+Alzheimer%27s+disease+with+a+new+formulation.&rft.volume=7&rft.issue=3&rft.pages=349-62&rft.date=2011-06&rft_id=info%3Adoi%2F10.2217%2Fahe.11.31&rft.aulast=Makino&rft.aufirst=KM&rft.au=Porsteinsson%2C+AP&rft_id=http%3A%2F%2Fwww.medscape.com%2Fviewarticle%2F748581_4&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP2B6" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CYP2B6&action=edit&section=5" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGoundenvan_NiekerkSnymanGeorge2010" class="citation journal cs1">Gounden V, van Niekerk C, Snyman T, George JA (August 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933581">"Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients"</a>. <i>AIDS Research and Therapy</i>. <b>7</b>: 32. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1742-6405-7-32">10.1186/1742-6405-7-32</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933581">2933581</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20723261">20723261</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=AIDS+Research+and+Therapy&rft.atitle=Presence+of+the+CYP2B6+516G%3E+T+polymorphism%2C+increased+plasma+Efavirenz+concentrations+and+early+neuropsychiatric+side+effects+in+South+African+HIV-infected+patients&rft.volume=7&rft.pages=32&rft.date=2010-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2933581%23id-name%3DPMC&rft_id=info%3Apmid%2F20723261&rft_id=info%3Adoi%2F10.1186%2F1742-6405-7-32&rft.aulast=Gounden&rft.aufirst=V&rft.au=van+Niekerk%2C+C&rft.au=Snyman%2C+T&rft.au=George%2C+JA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2933581&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP2B6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYangKohJeong2010" class="citation journal cs1">Yang K, Koh KH, Jeong H (August 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697095">"Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes"</a>. <i>Drug Metabolism Letters</i>. <b>4</b> (3): 129–33. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2174%2F187231210791698410">10.2174/187231210791698410</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697095">3697095</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20642445">20642445</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drug+Metabolism+Letters&rft.atitle=Induction+of+CYP2B6+and+CYP3A4+expression+by+1-aminobenzotriazole+%28ABT%29+in+human+hepatocytes&rft.volume=4&rft.issue=3&rft.pages=129-33&rft.date=2010-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3697095%23id-name%3DPMC&rft_id=info%3Apmid%2F20642445&rft_id=info%3Adoi%2F10.2174%2F187231210791698410&rft.aulast=Yang&rft.aufirst=K&rft.au=Koh%2C+KH&rft.au=Jeong%2C+H&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3697095&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP2B6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNgaimisiMugusiMinziSasi2010" class="citation journal cs1">Ngaimisi E, Mugusi S, Minzi OM, Sasi P, Riedel KD, Suda A, Ueda N, Janabi M, Mugusi F, Haefeli WE, Burhenne J, Aklillu E (November 2010). "Long-term efavirenz autoinduction and its effect on plasma exposure in HIV patients". <i>Clinical Pharmacology and Therapeutics</i>. <b>88</b> (5): 676–84. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fclpt.2010.172">10.1038/clpt.2010.172</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20881953">20881953</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:24749169">24749169</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clinical+Pharmacology+and+Therapeutics&rft.atitle=Long-term+efavirenz+autoinduction+and+its+effect+on+plasma+exposure+in+HIV+patients&rft.volume=88&rft.issue=5&rft.pages=676-84&rft.date=2010-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A24749169%23id-name%3DS2CID&rft_id=info%3Apmid%2F20881953&rft_id=info%3Adoi%2F10.1038%2Fclpt.2010.172&rft.aulast=Ngaimisi&rft.aufirst=E&rft.au=Mugusi%2C+S&rft.au=Minzi%2C+OM&rft.au=Sasi%2C+P&rft.au=Riedel%2C+KD&rft.au=Suda%2C+A&rft.au=Ueda%2C+N&rft.au=Janabi%2C+M&rft.au=Mugusi%2C+F&rft.au=Haefeli%2C+WE&rft.au=Burhenne%2C+J&rft.au=Aklillu%2C+E&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP2B6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSmithStubbinsHarriesWolf1998" class="citation journal cs1">Smith G, Stubbins MJ, Harries LW, Wolf CR (December 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". <i>Xenobiotica; the Fate of Foreign Compounds in Biological Systems</i>. <b>28</b> (12): 1129–65. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F004982598238868">10.1080/004982598238868</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9890157">9890157</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+Fate+of+Foreign+Compounds+in+Biological+Systems&rft.atitle=Molecular+genetics+of+the+human+cytochrome+P450+monooxygenase+superfamily&rft.volume=28&rft.issue=12&rft.pages=1129-65&rft.date=1998-12&rft_id=info%3Adoi%2F10.1080%2F004982598238868&rft_id=info%3Apmid%2F9890157&rft.aulast=Smith&rft.aufirst=G&rft.au=Stubbins%2C+MJ&rft.au=Harries%2C+LW&rft.au=Wolf%2C+CR&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP2B6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSvärdSpiersMulcahyHennessy2010" class="citation journal cs1">Svärd J, Spiers JP, Mulcahy F, Hennessy M (December 2010). <a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FQAI.0b013e3181f52f0c">"Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans"</a>. <i>Journal of Acquired Immune Deficiency Syndromes</i>. <b>55</b> (5): 536–49. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FQAI.0b013e3181f52f0c">10.1097/QAI.0b013e3181f52f0c</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20861742">20861742</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:205996665">205996665</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Acquired+Immune+Deficiency+Syndromes&rft.atitle=Nuclear+receptor-mediated+induction+of+CYP450+by+antiretrovirals%3A+functional+consequences+of+NR1I2+%28PXR%29+polymorphisms+and+differential+prevalence+in+whites+and+sub-Saharan+Africans&rft.volume=55&rft.issue=5&rft.pages=536-49&rft.date=2010-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A205996665%23id-name%3DS2CID&rft_id=info%3Apmid%2F20861742&rft_id=info%3Adoi%2F10.1097%2FQAI.0b013e3181f52f0c&rft.aulast=Sv%C3%A4rd&rft.aufirst=J&rft.au=Spiers%2C+JP&rft.au=Mulcahy%2C+F&rft.au=Hennessy%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1097%252FQAI.0b013e3181f52f0c&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACYP2B6" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMelansonStevensonKimAntin2010" class="citation journal cs1">Melanson SE, Stevenson K, Kim H, Antin JH, Court MH, Ho VT, Ritz J, Soiffer RJ, Kuo FC, Longtine JA, Jarolim P (December 2010). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fajh.21889">"Allelic variations in CYP2B6 and CYP2C19 and survival of patients receiving cyclophosphamide prior to myeloablative hematopoietic stem cell transplantation"</a>. <i>American Journal of Hematology</i>. <b>85</b> (12): 967–71. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fajh.21889">10.1002/ajh.21889</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21108329">21108329</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" 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rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=CYP2B6">CYP2B6</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CYP2B6"><i>CYP2B6</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CYP2B6"><i>CYP2B6</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P20813">P20813</a></i> (Cytochrome P450 2B6) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <p><i>This article incorporates text from the <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</i> </p> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl 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title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cytochrome_P450" title="Special:EditPage/Template:Cytochrome P450"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytochromes,_oxygenases:_cytochrome_P450_(Most_belong_to_EC_1.14)" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytochrome" title="Cytochrome">Cytochromes</a>, <a href="/wiki/Oxygenase" title="Oxygenase">oxygenases</a>: <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> (Most belong to <a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 1.14)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP1</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP1A1" title="CYP1A1">A1</a></li> <li><a href="/wiki/CYP1A2" title="CYP1A2">A2</a></li> <li><a href="/w/index.php?title=CYP1A5&action=edit&redlink=1" class="new" title="CYP1A5 (page does not exist)">A5</a></li> <li><a href="/wiki/CYP1B1" title="CYP1B1">B1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP2</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP2A6" title="CYP2A6">A6</a></li> <li><a href="/wiki/CYP2A7" title="CYP2A7">A7</a></li> <li><a href="/wiki/CYP2A13" title="CYP2A13">A13</a></li> <li><a class="mw-selflink selflink">B6</a></li> <li><a href="/wiki/CYP2C8" title="CYP2C8">C8</a></li> <li><a href="/wiki/CYP2C9" title="CYP2C9">C9</a></li> <li><a href="/wiki/CYP2C18" title="CYP2C18">C18</a></li> <li><a href="/wiki/CYP2C19" title="CYP2C19">C19</a></li> <li><a href="/wiki/CYP2D6" title="CYP2D6">D6</a></li> <li><a href="/wiki/CYP2E1" title="CYP2E1">E1</a></li> <li><a href="/wiki/CYP2F1" title="CYP2F1">F1</a></li> <li><a href="/wiki/CYP2J2" title="CYP2J2">J2</a></li> <li><a href="/wiki/CYP2R1" title="CYP2R1">R1</a></li> <li><a href="/wiki/CYP2S1" title="CYP2S1">S1</a></li> <li><a href="/wiki/CYP2U1" title="CYP2U1">U1</a></li> <li><a href="/wiki/CYP2W1" title="CYP2W1">W1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP3 (<a href="/wiki/CYP3A" title="CYP3A">CYP3A</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP3A4" title="CYP3A4">A4</a></li> <li><a href="/wiki/CYP3A5" title="CYP3A5">A5</a></li> <li><a href="/wiki/CYP3A7" title="CYP3A7">A7</a></li> <li><a href="/w/index.php?title=CYP3A37&action=edit&redlink=1" class="new" title="CYP3A37 (page does not exist)">A37</a></li> <li><a href="/wiki/CYP3A43" title="CYP3A43">A43</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP4</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CYP4A11" title="CYP4A11">A11</a></li> <li><a href="/wiki/CYP4A22" title="CYP4A22">A22</a></li> <li><a href="/wiki/CYP4B1" title="CYP4B1">B1</a></li> <li><a href="/wiki/CYP4F2" title="CYP4F2">F2</a></li> <li><a href="/wiki/CYP4F3" title="CYP4F3">F3</a></li> <li><a href="/wiki/CYP4F8" title="CYP4F8">F8</a></li> <li><a href="/wiki/CYP4F11" title="CYP4F11">F11</a></li> <li><a href="/wiki/CYP4F12" title="CYP4F12">F12</a></li> <li><a href="/wiki/CYP4F22" title="CYP4F22">F22</a></li> <li><a href="/wiki/CYP4V2" title="CYP4V2">V2</a></li> <li><a href="/wiki/CYP4X1" title="CYP4X1">X1</a></li> <li><a href="/wiki/CYP4Z1" title="CYP4Z1">Z1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP5-20</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP5</i> (<a href="/wiki/Thromboxane-A_synthase" title="Thromboxane-A synthase">A1</a>)</li> <li><i><a href="/wiki/CYP6_family" title="CYP6 family">CYP6</a></i> (<a href="/wiki/CYP6G1" title="CYP6G1">G1</a>, <a href="/wiki/CYP6M2" title="CYP6M2">M2</a>)</li> <li><i>CYP7</i> (<a href="/wiki/Cholesterol_7_alpha-hydroxylase" title="Cholesterol 7 alpha-hydroxylase">A1</a>, <a href="/wiki/CYP7B1" title="CYP7B1">B1</a>)</li> <li><i>CYP8</i> (<a href="/wiki/CYP8A1" class="mw-redirect" title="CYP8A1">A1</a>, <a href="/wiki/CYP8B1" title="CYP8B1">B1</a>)</li> <li><i><a href="/wiki/CYP9_family" title="CYP9 family">CYP9</a></i></li> <li><i><a href="/wiki/CYP10_family" title="CYP10 family">CYP10</a></i></li> <li><i><a href="/wiki/CYP11_family" title="CYP11 family">CYP11</a></i> (<a href="/wiki/Cholesterol_side-chain_cleavage_enzyme" title="Cholesterol side-chain cleavage enzyme">A1</a>, <a href="/wiki/CYP11A2" title="CYP11A2">A2</a>, <a href="/wiki/Steroid_11-beta-hydroxylase" class="mw-redirect" title="Steroid 11-beta-hydroxylase">B1</a>, <a href="/wiki/Aldosterone_synthase" title="Aldosterone synthase">B2</a>, <a href="/wiki/CYP11B3" title="CYP11B3">B3</a>, <a href="/wiki/CYP11C1" title="CYP11C1">C1</a>)</li> <li><i><a href="/wiki/CYP12_family" title="CYP12 family">CYP12</a></i></li> <li><i><a href="/wiki/CYP13_family" title="CYP13 family">CYP13</a></i></li> <li><i><a href="/wiki/CYP14_family" title="CYP14 family">CYP14</a></i></li> <li><i><a href="/wiki/CYP15_family" title="CYP15 family">CYP15</a></i></li> <li><i><a href="/wiki/CYP16_family" title="CYP16 family">CYP16</a></i></li> <li><i>CYP17</i> (<a href="/wiki/CYP17A1" title="CYP17A1">A1</a>)</li> <li><i><a href="/wiki/CYP18_family" title="CYP18 family">CYP18</a></i></li> <li><i>CYP19</i> (<a href="/wiki/Aromatase" title="Aromatase">A1</a>)</li> <li><i>CYP20</i> (<a href="/wiki/CYP20A1" title="CYP20A1">A1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP21-49</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP21</i> (<a href="/wiki/21-Hydroxylase" title="21-Hydroxylase">A2</a>)</li> <li><i>CYP22</i> (<a href="/wiki/Daf-9" title="Daf-9">A1</a>)</li> <li><i><a href="/wiki/CYP23_family" title="CYP23 family">CYP23</a></i></li> <li><i>CYP24</i> (<a href="/wiki/CYP24A1" title="CYP24A1">A1</a>)</li> <li><i><a href="/wiki/CYP25_family" title="CYP25 family">CYP25</a></i></li> <li><i><a href="/wiki/CYP26_family" title="CYP26 family">CYP26</a></i> (<a href="/wiki/CYP26A1" title="CYP26A1">A1</a>, <a href="/wiki/CYP26B1" title="CYP26B1">B1</a>, <a href="/wiki/CYP26C1" title="CYP26C1">C1</a>)</li> <li><i><a href="/wiki/CYP27_family" title="CYP27 family">CYP27</a></i> (<a href="/wiki/CYP27A1" title="CYP27A1">A1</a>, <a href="/wiki/25-Hydroxyvitamin_D3_1-alpha-hydroxylase" class="mw-redirect" title="25-Hydroxyvitamin D3 1-alpha-hydroxylase">B1</a>, <a href="/wiki/CYP27C1" title="CYP27C1">C1</a>)</li> <li><i>CYP28</i> (<a href="/wiki/CYP28A1" title="CYP28A1">A1</a>)</li> <li><i><a href="/w/index.php?title=CYP29_family&action=edit&redlink=1" class="new" title="CYP29 family (page does not exist)">CYP29</a></i></li> <li><i>CYP35</i> (<a href="/wiki/CYP35B1" title="CYP35B1">B1</a>)</li> <li><i>CYP39</i> (<a href="/wiki/CYP39A1" title="CYP39A1">A1</a>)</li> <li><i>CYP46</i> (<a href="/wiki/CYP46A1" class="mw-redirect" title="CYP46A1">A1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP51-69</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Sterol_14-demethylase" title="Sterol 14-demethylase">CYP51</a></i> (<a href="/wiki/Lanosterol_14_alpha-demethylase" title="Lanosterol 14 alpha-demethylase">A1</a>, <a href="/wiki/ERG11" title="ERG11">F1</a>)</li> <li><i><a href="/wiki/CYP52_family" title="CYP52 family">CYP52</a></i></li> <li><i><a href="/wiki/CYP53_family" title="CYP53 family">CYP53</a></i> <ul><li><a href="/wiki/Benzoate_4-monooxygenase" title="Benzoate 4-monooxygenase">A1</a></li></ul></li> <li><i><a href="/wiki/CYP55_family" title="CYP55 family">CYP55</a></i> <ul><li><a href="/wiki/Nitric_oxide_reductase_(NAD(P),_nitrous_oxide-forming)" title="Nitric oxide reductase (NAD(P), nitrous oxide-forming)">A1</a></li></ul></li> <li><i>CYP56</i> <ul><li><a href="/wiki/CYP56A1" title="CYP56A1">A1</a></li></ul></li> <li><i><a href="/wiki/ERG5" title="ERG5">CYP61</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP71-99</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CYP71</i> (<a href="/wiki/3-hydroxyindolin-2-one_monooxygenase" title="3-hydroxyindolin-2-one monooxygenase">C1</a>, <a href="/wiki/Indolin-2-one_monooxygenase" title="Indolin-2-one monooxygenase">C2</a>, <a href="/wiki/2-Hydroxy-1,4-benzoxazin-3-one_monooxygenase" title="2-Hydroxy-1,4-benzoxazin-3-one monooxygenase">C3</a>, <a href="/wiki/Indole-2-monooxygenase" title="Indole-2-monooxygenase">C4</a>, <a href="/wiki/Ent-isokaurene_C2-hydroxylase" title="Ent-isokaurene C2-hydroxylase">Z6</a>, <a href="/wiki/Angelicin_synthase" title="Angelicin synthase">AJ4</a>, <a href="/wiki/Amorpha-4,11-diene_12-monooxygenase" title="Amorpha-4,11-diene 12-monooxygenase">AV1</a>, <a href="/wiki/Alpha-humulene_10-hydroxylase" title="Alpha-humulene 10-hydroxylase">BA1</a>)</li> <li><i><a href="/wiki/Secologanin_synthase" title="Secologanin synthase">CYP72A1</a></i></li> <li><i><a href="/wiki/Trans-cinnamate_4-monooxygenase" title="Trans-cinnamate 4-monooxygenase">CYP73A1</a></i></li> <li><i><a href="/wiki/CYP74_family" title="CYP74 family">CYP74</a></i> (<a href="/wiki/Colneleate_synthase" title="Colneleate synthase">D1</a>)</li> <li><i>CYP75</i> (<a href="/wiki/Flavonoid_3%27,5%27-hydroxylase" title="Flavonoid 3',5'-hydroxylase">A1</a>, <a href="/wiki/Flavonoid_3%27-monooxygenase" title="Flavonoid 3'-monooxygenase">B1</a>)</li> <li><i><a href="/wiki/CYP76_family" title="CYP76 family">CYP76</a></i> (<a href="/wiki/Geraniol_8-hydroxylase" title="Geraniol 8-hydroxylase">B6</a>, <a href="/wiki/Ent-cassa-12,15-diene_11-hydroxylase" title="Ent-cassa-12,15-diene 11-hydroxylase">M7</a>)</li> <li><i>CYP79</i> (<a href="/wiki/Tyrosine_N-monooxygenase" title="Tyrosine N-monooxygenase">A1</a>, <a href="/wiki/Phenylalanine_N-monooxygenase" title="Phenylalanine N-monooxygenase">A2</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B1</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B2</a>, <a href="/wiki/Tryptophan_N-monooxygenase" title="Tryptophan N-monooxygenase">B3</a>, <a href="/wiki/Valine_N-monooxygenase" title="Valine N-monooxygenase">D1</a>, <a href="/wiki/Valine_N-monooxygenase" title="Valine N-monooxygenase">D2</a>, <a href="/wiki/Isoleucine_N-monooxygenase" title="Isoleucine N-monooxygenase">D3</a>, <a href="/wiki/Isoleucine_N-monooxygenase" title="Isoleucine N-monooxygenase">D4</a>)</li> <li><i>CYP80</i> (<a href="/wiki/Berbamunine_synthase" title="Berbamunine synthase">A1</a>, <a href="/wiki/N-methylcoclaurine_3%27-monooxygenase" title="N-methylcoclaurine 3'-monooxygenase">B1</a>, <a href="/wiki/(S)-corytuberine_synthase" title="(S)-corytuberine synthase">G2</a>)</li> <li><i>CYP81</i> (<a href="/wiki/Isoflavone_2%27-hydroxylase" title="Isoflavone 2'-hydroxylase">E1</a>, <a href="/wiki/4%27-methoxyisoflavone_2%27-hydroxylase" title="4'-methoxyisoflavone 2'-hydroxylase">E3</a>, <a href="/wiki/4%27-methoxyisoflavone_2%27-hydroxylase" title="4'-methoxyisoflavone 2'-hydroxylase">E7</a>, <a href="/wiki/Isoflavone_3%27-hydroxylase" title="Isoflavone 3'-hydroxylase">E9</a>)</li> <li><i><a href="/wiki/Beta-amyrin_11-oxidase" title="Beta-amyrin 11-oxidase">CYP88D6</a></i></li> <li><i><a href="/wiki/3-Epi-6-deoxocathasterone_23-monooxygenase" title="3-Epi-6-deoxocathasterone 23-monooxygenase">CYP90C1</a></i></li> <li><i><a href="/wiki/Beta-amyrin_24-hydroxylase" title="Beta-amyrin 24-hydroxylase">CYP93E1</a></i></li> <li><i><a href="/wiki/Carotene_epsilon-monooxygenase" title="Carotene epsilon-monooxygenase">CYP97C1</a></i></li> <li><i><a href="/wiki/9beta-pimara-7,15-diene_oxidase" title="9beta-pimara-7,15-diene oxidase">CYP99A3</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP101-281</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Camphor_5-monooxygenase" title="Camphor 5-monooxygenase">CYP101A1</a></i></li> <li><i><a href="/wiki/Cytochrome_P450_BM3" title="Cytochrome P450 BM3">CYP102A1</a></i></li> <li><i><a href="/wiki/CYP105_family" title="CYP105 family">CYP105</a></i> <ul><li><a href="/wiki/Vitamin_D3_dihydroxylase" title="Vitamin D3 dihydroxylase">A1</a></li> <li><a href="/wiki/Pentalenic_acid_synthase" title="Pentalenic acid synthase">D7</a></li></ul></li> <li><i><a href="/wiki/Steroid_15beta-monooxygenase" title="Steroid 15beta-monooxygenase">CYP106A2</a></i></li> <li><i><a href="/wiki/CYP107_family" title="CYP107 family">CYP107</a></i> <ul><li><a href="/wiki/Cytochrome_P450_eryF" title="Cytochrome P450 eryF">A1</a></li> <li><a href="/wiki/CYP107G1" title="CYP107G1">G1</a></li></ul></li> <li><i><a href="/wiki/CYP109_family" title="CYP109 family">CYP109</a></i> <ul><li><a href="/wiki/CYP109B1" title="CYP109B1">B1</a></li> <li><a href="/wiki/CYP109E1" title="CYP109E1">E1</a></li></ul></li> <li><i><a href="/wiki/Linalool_8-monooxygenase" title="Linalool 8-monooxygenase">CYP111</a></i></li> <li><i><a href="/wiki/Erythromycin_12_hydroxylase" title="Erythromycin 12 hydroxylase">CYP113A1</a></i></li> <li><i><a href="/wiki/CYP119A1" title="CYP119A1">CYP119A1</a></i></li> <li><i><a href="/wiki/CYP123_family" title="CYP123 family">CYP123</a></i></li> <li><i><a href="/wiki/Cholest-4-en-3-one_26-monooxygenase" title="Cholest-4-en-3-one 26-monooxygenase">CYP125A1</a></i></li> <li><i><a href="/wiki/CYP139_family" title="CYP139 family">CYP139</a></i></li> <li><i><a href="/wiki/CYP147_family" title="CYP147 family">CYP147</a></i></li> <li><i><a href="/wiki/Fatty-acid_peroxygenase" title="Fatty-acid peroxygenase">CYP152</a></i> <ul><li>A1</li> <li>B1</li></ul></li> <li><i><a href="/wiki/CYP154C3" title="CYP154C3">CYP154C3</a></i></li> <li><i><a href="/wiki/Biflaviolin_synthase" title="Biflaviolin synthase">CYP158A</a></i></li> <li><i><a href="/wiki/Pentalenolactone_synthase" title="Pentalenolactone synthase">CYP161C</a></i></li> <li><i>CYP170</i> <ul><li><i><a href="/wiki/Epi-isozizaene_5-monooxygenase" title="Epi-isozizaene 5-monooxygenase">A1</a></i></li> <li><i><a href="/wiki/CYP170B1" title="CYP170B1">B1</a></i></li></ul></li> <li><i><a href="/wiki/1,8-Cineole_2-endo-monooxygenase" title="1,8-Cineole 2-endo-monooxygenase">CYP176A1</a></i></li> <li><i><a href="/wiki/Pentalenene_oxygenase" title="Pentalenene oxygenase">CYP183A</a></i></li> <li><i><a href="/wiki/CYP197_family" title="CYP197 family">CYP197</a></i></li> <li><i><a href="/wiki/4-methoxybenzoate_monooxygenase_(O-demethylating)" title="4-methoxybenzoate monooxygenase (O-demethylating)">CYP199A2</a></i></li> <li><i><a href="/wiki/Cytochrome_P450_aromatic_O-demethylase" title="Cytochrome P450 aromatic O-demethylase">CYP255A</a> </i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP301-499</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CYP303A1" title="CYP303A1">CYP303A1</a></i></li> <li><i><a href="/wiki/CYP305_family" title="CYP305 family">CYP305</a></i> <ul><li><a href="/wiki/CYP305M2" title="CYP305M2">M2</a></li></ul></li> <li><a href="/wiki/Halloween_genes" title="Halloween genes">Halloween genes</a> ( <i>CYP302A1</i>, <i>CYP306A1</i>, <i>CYP307A1</i>, <i>CYP307A2</i>, <i><a href="/wiki/Ecdysone_20-monooxygenase" title="Ecdysone 20-monooxygenase">CYP314A1</a></i>, <i>CYP315A1</i>)</li> <li><i><a href="/wiki/CYP318A1" title="CYP318A1">CYP318A1</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP501-699</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Ent-kaurene_oxidase" title="Ent-kaurene oxidase">CYP503</a></i></li> <li><i><a href="/wiki/3-hydroxyphenylacetate_6-hydroxylase" title="3-hydroxyphenylacetate 6-hydroxylase">CYP504B1</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">CYP701-999</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CYP704B22" class="mw-redirect" title="CYP704B22">CYP704B22</a></i></li> <li><i><a href="/wiki/CYP710_family" title="CYP710 family">CYP710</a></i></li> <li><i><a href="/wiki/Abietadienol_hydroxylase" title="Abietadienol hydroxylase">CYP720A1</a></i></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;padding:0.15em 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