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Small Molecules & TPD World Series - GPCRs Targeted Drug Discovery Summit
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</div> </div> </div> </div> </div> </div> </div> </div> </header> <div id="fl-main-content" class="fl-page-content" itemprop="mainContentOfPage" role="main"> <div class="fl-content-full container"> <div class="row"> <div class="fl-content col-md-12"> <article class="fl-post post-22573 page type-page status-publish hentry" id="fl-post-22573" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-22573 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="22573"><div class="fl-row fl-row-fixed-width fl-row-bg-photo fl-node-67edwzx3bys5 fl-row-default-height fl-row-align-center" data-node="67edwzx3bys5"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-5zo3alyp2vkg" data-node="5zo3alyp2vkg"> <div class="fl-col fl-node-r3cfi7xh5vl1 fl-col-bg-photo" data-node="r3cfi7xh5vl1"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-bdumz4apx67c" data-node="bdumz4apx67c"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">Small Molecules & TPD World Series</span> </h2> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-4fh01zyws6bl fl-row-default-height fl-row-align-center" data-node="4fh01zyws6bl"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-uantrmgo6bc1" data-node="uantrmgo6bc1"> <div class="fl-col fl-node-g3webx46jdcs fl-col-bg-color fl-col-has-cols" data-node="g3webx46jdcs"> <div class="fl-col-content fl-node-content"> <div class="fl-col-group fl-node-5g4l1qyuv9dt fl-col-group-nested" data-node="5g4l1qyuv9dt"> <div class="fl-col fl-node-25cetam4z90u fl-col-bg-color" data-node="25cetam4z90u"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-rich-text fl-node-42pj0aktrqys" data-node="42pj0aktrqys"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p><span style="font-size: 16px;">The <strong>Small Molecules and TPD World Series</strong> is committed to delivering the most comprehensive collection of industry-dedicated forums, exclusively focusing on the specific challenges faced for each community of small molecules and protein degradation drug developers.</span></p> <p><span style="font-size: 16px;">The goal for this event series is to provide your team with the platform to connect, learn and fast-track first-in-class or next generation of selective, orally bioavailable and clinically efficacious small molecules for undrugged or hard-to-drug targets to meet the needs of patients globally.</span></p> <p><span style="font-size: 16px;">View the<strong> Small Molecules & TPD World Series</strong> conference calendar below. If you have any questions, get in touch at <a href="mailto:info@hansonwade.com?subject=Small%20Molecules%20%26%20TPD%20World%20Series%20-%20Enquiry">info@hansonwade.com</a>.</span></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-q2mxfvds457p" data-node="q2mxfvds457p"> <div class="fl-col fl-node-n0stuiwrgdxa fl-col-bg-color" data-node="n0stuiwrgdxa"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-separator fl-node-75io8bxlz2md" data-node="75io8bxlz2md"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-ityu9sh0bnp2 fl-row-default-height fl-row-align-center" data-node="ityu9sh0bnp2"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-la9cpv4z6ud5" data-node="la9cpv4z6ud5"> <div 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height="440" width="2048" title="Induced Proximity" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-xuo0p5e6lf79" data-node="xuo0p5e6lf79"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Successfully Screen & Validate Novel Protein-Protein Inducing Mechanisms & Chemical Matters to Improve the Selectivity & Off-Target Effect of Your Degrader & Non-Degrader Proximity-Based Drugs from Discovery to Clinic</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-8kxifpr13vaz" data-node="8kxifpr13vaz"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-vhdqx8jrc9i6" data-node="vhdqx8jrc9i6"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>July 23-25, 2024 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://induced-proximity-summit.com/?utm_source=internal&utm_medium=event&utm_campaign=conference&utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #1945b1;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-784mwkepsb0z fl-col-bg-color fl-col-small" data-node="784mwkepsb0z"> <div class="fl-col-content fl-node-content"><div id="rnai" class="fl-module fl-module-photo fl-node-6jt9sb2ge0ka fl-animation fl-fade-up" data-node="6jt9sb2ge0ka" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-21863 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2023/12/21516-6th-RAS-Targeted-Drug-Discovery-Summit-logo.png" alt="21516 6th RAS Targeted Drug Discovery Summit logo" itemprop="image" height="1928" width="7576" title="21516 6th RAS Targeted Drug Discovery Summit logo" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-7uhiqs143r68" data-node="7uhiqs143r68"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Overcome Diverse Clinical Resistance Mechanisms with Emerging First- & Best-In-Class Combination & Monotherapies to Effectively Treat Patients with RAS-Driven Lung, Colorectal & Pancreatic Cancers</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-uy4tg2v1qh80" data-node="uy4tg2v1qh80"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-tfm45dusc9xn" data-node="tfm45dusc9xn"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>September 24-26, 2024 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://ras-drugdevelopment.com/?utm_source=internal&utm_medium=event&utm_campaign=conference&utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #d82763;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-o7en96xd4vri fl-col-group-nested fl-col-group-equal-height fl-col-group-align-top" data-node="o7en96xd4vri"> <div class="fl-col fl-node-kouayz2q3icg fl-col-bg-color fl-col-small" data-node="kouayz2q3icg"> <div class="fl-col-content fl-node-content"><div id="europe" class="fl-module fl-module-photo fl-node-8z3ubcdsw7np fl-animation fl-fade-up" data-node="8z3ubcdsw7np" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22586 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/TPD-US.png" alt="TPD US" itemprop="image" height="515" width="2048" title="TPD US" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-eq5ft1zjwryp" data-node="eq5ft1zjwryp"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Fast-Track Discovery, Development & Approval of Selective, Safe & Clinically Relevant TACs & Glues for Degradation, Stabilization, & Phosphorylation to Successfully Address Unmet Need in Oncology & Beyond</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-why46nfirvlt" data-node="why46nfirvlt"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-hj5st2ea3nu0" data-node="hj5st2ea3nu0"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>October 29-31, 2024 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://proteindegradation.com/?utm_source=internal&utm_medium=event&utm_campaign=conference&utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #1278ab;"><strong><span style="color: #019745;">LEARN MORE</span></strong></span></a></p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-ujs04ixh5fwa fl-col-bg-color fl-col-small" data-node="ujs04ixh5fwa"> <div class="fl-col-content fl-node-content"><div id="rnai" class="fl-module fl-module-photo fl-node-2hs35dm0fp4k fl-animation fl-fade-up" data-node="2hs35dm0fp4k" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22585 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/HW240707-49702-GPCRs-Targeted-Drug-Discovery-Summit-Europe-l.png" alt="GPCRs Targeted Drug Discovery Summit Europe" itemprop="image" height="1589" width="7036" title="HW240707 49702 GPCRs-Targeted Drug Discovery Summit Europe l" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-7bn9xu0pj4rd" data-node="7bn9xu0pj4rd"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Leverage Advances in Structural Biology, Screening & Target Validation Whilst Overcoming Pharmacology Challenges to Successfully Translate Your Small Molecules & Biologics from Novel Discoveries to Clinically Relevant & Effective GPCR Drugs</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-ft1qwjvi695o" data-node="ft1qwjvi695o"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-x4rp8by9q7os" data-node="x4rp8by9q7os"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>26-28 November, 2024 | London, UK</strong></p> <p style="text-align: center;"><span style="color: #0f4c8e;"><a style="color: #0f4c8e;" href="https://gpcrs-europe.com/?utm_source=internal&utm_medium=event&utm_campaign=conference&utm_content=small-molecules-next-series%2Fev-49702" target="_blank" rel="noopener"><strong>LEARN MORE</strong></a></span></p> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-imq3dwpc6b7j fl-col-group-nested fl-col-group-equal-height fl-col-group-align-top" data-node="imq3dwpc6b7j"> <div class="fl-col fl-node-qfdwey29n7z4 fl-col-bg-color fl-col-small" data-node="qfdwey29n7z4"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-sdaxtlhpco16 fl-animation fl-fade-up" data-node="sdaxtlhpco16" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22582 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/Hippo-Pathway-Targeted-Drug-Development-Summit-Strapline.png" alt="Hippo-Pathway-Targeted-Drug-Development-Summit" itemprop="image" height="683" width="3366" title="Hippo Pathway Targeted Drug Development Summit Strapline" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-jxcal0fvogub" data-node="jxcal0fvogub"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p class="fl-heading" style="text-align: center;">Improve Selectivity, Reduce Toxicity & Overcome Limitations of Preclinical Models & Clinical Biomarkers to Accelerate Translation & Development of Hippo Pathway Targeted Therapeutics for Patients</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-lyf7zk469u2m" data-node="lyf7zk469u2m"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-bypaojdf05hl" data-node="bypaojdf05hl"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong><span class="fl-heading-text">November, 2024 | Virtual</span></strong></p> <p> </p> <p style="text-align: center;"><a href="https://hippo-pathway.com/?utm_source=internal&utm_medium=event&utm_campaign=conference&utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #0b5d7a;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-d28ln975tj3p fl-col-bg-color fl-col-small" data-node="d28ln975tj3p"> <div class="fl-col-content fl-node-content"><div id="processdev" class="fl-module fl-module-photo fl-node-gyi364cuqmds fl-animation fl-fade-up" data-node="gyi364cuqmds" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22583 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/Covalent-Drug-Discovery-Development.png" alt="Covalent Drug Discovery Development" itemprop="image" height="420" width="2048" title="Covalent Drug Discovery Development" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-no1r2p4ybflt" data-node="no1r2p4ybflt"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Discover & Develop Selective, Clinically Validated & Novel Covalent Therapeutics to Expand the Targetable Proteome & Non-Cystine Amino Acid Space in Oncology, Immunology & Beyond</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-9i13h8spd6u0" data-node="9i13h8spd6u0"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-pvxl4g5703cz" data-node="pvxl4g5703cz"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>December 10-12, 2024 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://covalent-drug-discovery.com//?utm_source=internal&utm_medium=event&utm_campaign=conference&utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #c55099;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-73lahm0o6iq8 fl-col-group-nested fl-col-group-equal-height fl-col-group-align-top" data-node="73lahm0o6iq8"> <div class="fl-col fl-node-957sfv8dpky2 fl-col-bg-color fl-col-small" data-node="957sfv8dpky2"> <div class="fl-col-content fl-node-content"><div id="rnai" class="fl-module fl-module-photo fl-node-rkuanvp4djoe fl-animation fl-fade-up" data-node="rkuanvp4djoe" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-22580 size-full" src="https://tpd-europe.com/wp-content/uploads/sites/180/2024/07/Molecular-Glue-Drug-Development-Summit-.png" alt="Molecular Glue Drug Development Summit" itemprop="image" height="767" width="3294" title="Molecular Glue Drug Development Summit" /> </div> </div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-x2iw1yz3mjh0" data-node="x2iw1yz3mjh0"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;">Accelerate the Discovery, Validation and Clinical Translation of Novel and Rationally Designed Molecular Glues through Systematic Screening, Expanding Ligase Toolbox and Optimizing Pharmacological Properties</p> </div> </div> </div> <div class="fl-module fl-module-separator fl-node-x1y8vbezhad4" data-node="x1y8vbezhad4"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> <div class="fl-module fl-module-rich-text fl-node-1ol0cnkd4gar" data-node="1ol0cnkd4gar"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p style="text-align: center;"><strong>Returning January, 2025 | Boston, MA</strong></p> <p></p> <p style="text-align: center;"><a href="https://molecular-glue-summit.com/?utm_source=internal&utm_medium=event&utm_campaign=conference&utm_content=small-molecules-next-in-series" target="_blank" rel="noopener"><span style="color: #53bac1;"><strong>LEARN MORE</strong></span></a></p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-p3q9ho5g1xnt fl-col-bg-color fl-col-small" data-node="p3q9ho5g1xnt"> <div class="fl-col-content fl-node-content"><div id="rnai" class="fl-module fl-module-photo fl-node-jwrvgcs1m20i fl-animation fl-fade-up" data-node="jwrvgcs1m20i" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-center" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-23650 size-full" 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FLBuilderMenu({id:'5ba0ab906f568',type:'horizontal',mobile:'expanded',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'198',mobileStacked:true,});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-616fee3f618ca .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-61813dfd1d5cf .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){$(function(){new FLBuilderMenu({id:'5cf921a0e4984',type:'accordion',mobile:'hamburger',mobileBelowRow:false,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'always',postId:'198',mobileStacked:true,});});})(jQuery);;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof 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if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} if(this.hasAdminBar&&this.win.width()<=600){wpAdminBarHeight=Math.floor($('#wpadminbar').outerHeight());} totalHeaderHeight=Math.floor(beforeHeaderHeight+headerHeight);if(headerHeight>0){var headerParent=this.header.parent(),headerParentTopPadding=0;if($(headerParent).is('body')){headerParentTopPadding=Math.floor(headerHeight-wpAdminBarHeight);}else{headerParentTopPadding=Math.floor(headerHeight-bodyTopPadding-wpAdminBarHeight);} $(headerParent).css('padding-top',(headerParentTopPadding-beforeHeaderFix)+'px');this.header.css({'-webkit-transform':'translate(0px, -'+totalHeaderHeight+'px)','-ms-transform':'translate(0px, -'+totalHeaderHeight+'px)','transform':'translate(0px, -'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var image=$(this),maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.css('max-height',shrinkImageHeight);}});this.header.find('.fl-row-content-wrap').each(function(){var row=$(this);if(parseInt(row.css('padding-bottom'))>5){row.addClass('fl-theme-builder-header-shrink-row-bottom');} if(parseInt(row.css('padding-top'))>5){row.addClass('fl-theme-builder-header-shrink-row-top');}});this.header.find('.fl-module-content').each(function(){var module=$(this);if(parseInt(module.css('margin-bottom'))>5){module.addClass('fl-theme-builder-header-shrink-module-bottom');} if(parseInt(module.css('margin-top'))>5){module.addClass('fl-theme-builder-header-shrink-module-top');}});}}else if(hasClass){this.header.find('img').css('max-height','');this._removeShrink();} if('undefined'===typeof(e)&&$('body').hasClass('fl-fixed-width')){if(!this.overlay){this._adjustHeaderHeight();}}},_removeShrink:function(){var rows=this.header.find('.fl-row-content-wrap'),modules=this.header.find('.fl-module-content');rows.removeClass('fl-theme-builder-header-shrink-row-bottom');rows.removeClass('fl-theme-builder-header-shrink-row-top');modules.removeClass('fl-theme-builder-header-shrink-module-bottom');modules.removeClass('fl-theme-builder-header-shrink-module-top');this.header.removeClass('fl-theme-builder-header-shrink');},_setImageMaxHeight:function(){var head=$('head'),stylesId='fl-header-styles-'+this.header.data('post-id'),styles='',images=this.header.find('.fl-module-content img');if($('#'+stylesId).length){return;} images.each(function(i){var image=$(this),height=image.height(),node=image.closest('.fl-module').data('node'),className='fl-node-'+node+'-img-'+i,maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.addClass(className);styles+='.'+className+' { max-height: '+(height?height:image[0].height)+'px }';}});if(''!==styles){head.append('<style id="'+stylesId+'">'+styles+'</style>');}},_removeImageMaxHeight:function(){$('#fl-header-styles-'+this.header.data('post-id')).remove();},};$(function(){FLThemeBuilderHeaderLayout.init();});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-r8upjdfiob5m 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