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class="source">来源：诺泽流体科技（上海）有限公司</div> <div class="newsContent"> <section id="nice" data-tool="mdnice编辑器" data-website="https://www.mdnice.com" style="font-size: 16px; padding: 0px 10px; line-height: 1.6; letter-spacing: 0px; word-break: break-word; overflow-wrap: break-word; font-family: Optima-Regular, Optima, PingFangSC-light, PingFangTC-light, "PingFang SC", Cambria, Cochin, Georgia, Times, "Times New Roman", serif;"><h1 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; border-bottom: 2px solid rgb(14, 136, 235); font-size: 1.4em; text-align: center;"><span class="prefix" style="display: none;"></span><span class="content" style="font-size: 1.4em; display: inline-block; color: rgb(14, 136, 235); padding: 3px 10px 1px; border-top-right-radius: 3px; border-top-left-radius: 3px; margin-right: 3px;">微射流均质机|脂质体均质分散</span><span class="suffix"></span></h1><h2 data-tool="mdnice编辑器" style="padding: 0px; font-size: 22px; margin: 20px 10px 0px 0px;"><span class="prefix" style="display: none;"></span><span class="content" style="font-family: STHeitiSC-Light; color: rgb(14, 136, 235); font-weight: bolder; display: inline-block; padding-left: 10px; border-left: 5px solid rgb(14, 136, 235);">脂质体</span><span class="suffix"></span></h2><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">脂质体（liposome）是一种人工膜。在水中磷脂分子亲水头部插入水中，脂质体疏水尾部伸向空气，搅动后形成双层脂分子的球形脂质体，直径25~1000nm不等。</p><h2 data-tool="mdnice编辑器" style="padding: 0px; font-size: 22px; margin: 20px 10px 0px 0px;"><span class="prefix" style="display: none;"></span><span class="content" style="font-family: STHeitiSC-Light; color: rgb(14, 136, 235); font-weight: bolder; display: inline-block; padding-left: 10px; border-left: 5px solid rgb(14, 136, 235);">脂质体分类</span><span class="suffix"></span></h2><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">脂质体按照所包含类脂质双分子层的层数不同，分为单室脂质体和多室脂质体。</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">小单室脂质体(SUV)：粒径约0.02～0.08um；大单室脂质体 (LUV）为单层大泡囊，粒径在0.1～lum。</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">多层双分子层的泡囊称为多室脂质体 (MIV)，粒径在1～5um之间。</p><h2 data-tool="mdnice编辑器" style="padding: 0px; font-size: 22px; margin: 20px 10px 0px 0px;"><span class="prefix" style="display: none;"></span><span class="content" style="font-family: STHeitiSC-Light; color: rgb(14, 136, 235); font-weight: bolder; display: inline-block; padding-left: 10px; border-left: 5px solid rgb(14, 136, 235);">微射流均质机制备脂质体</span><span class="suffix"></span></h2><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">目前报道的制备方法(如高压乳匀过滤法、注入法、旋转成膜水化法)均有工艺放大的可行性，但在研究的初期，就需关注工业化大生产需配套的仪器设备以及关键工艺环节的研究。根据目前的研究经验，对于旋转成膜水化后的产品，一般都不是很均匀，都需要经过匀质化处理 (如超声，高压乳匀)</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">微射流均质是高压乳匀的制备方法中常见的设备，均质压力可达30000psi,可大程度的减少处理次数，提高工作效率。</p><h3 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; font-size: 18px; color: rgb(14, 136, 235);"><span class="prefix" style="display: none;"></span><span class="content">微射流均质机的工作原理</span><span class="suffix" style="display: none;"></span></h3><figure data-tool="mdnice编辑器" style="margin: 0; margin-top: 10px; margin-bottom: 10px; display: flex; flex-direction: column; justify-content: center; align-items: center;"><img src="https://img43.huajx.com/9/20240219/638439517301399097485.png" alt="工作原理" style="max-width: 100%; border-radius: 0px 0px 5px 5px; display: block; margin: 20px auto; width: 85%; height: 100%; object-fit: contain; box-shadow: #84A1A8 0px 10px 15px;"/><figcaption style="margin-top: 5px; text-align: center; color: rgb(136, 136, 136); font-size: 12px; font-family: PingFangSC-Light;">工作原理</figcaption></figure><h3 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; font-size: 18px; color: rgb(14, 136, 235);"><span class="prefix" style="display: none;"></span><span class="content">微射流均质机的产业化设备</span><span class="suffix" style="display: none;"></span></h3><figure data-tool="mdnice编辑器" style="margin: 0; margin-top: 10px; margin-bottom: 10px; display: flex; flex-direction: column; justify-content: center; align-items: center;"><img src="https://img43.huajx.com/9/20240219/638439517306086677518.png" alt="" style="max-width: 100%; border-radius: 0px 0px 5px 5px; display: block; margin: 20px auto; width: 85%; height: 100%; object-fit: contain; box-shadow: #84A1A8 0px 10px 15px;"/></figure><h3 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; font-size: 18px; color: rgb(14, 136, 235);"><span class="prefix" style="display: none;"></span><span class="content">脂质体的质量控制与评价</span><span class="suffix" style="display: none;"></span></h3><h4 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; font-size: 18px;"><span class="prefix" style="display: none;"></span><span class="content">形态、粒径及其分布</span><span class="suffix" style="display: none;"></span></h4><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">采用扫描电镜、激光散射法或激光扫描法测定。根据给药途径不同要求其粒径不同。如注射给药脂质体的粒径应小于200nm，且分布均匀，呈正态性，跨距宜小</p><h4 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; font-size: 18px;"><span class="prefix" style="display: none;"></span><span class="content">包封率和载药量</span><span class="suffix" style="display: none;"></span></h4><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">包封率：包封率＝（脂质体中包封的药物/脂质体中药物总量）×％</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">一般采用葡聚糖凝胶、超速离心法、透析法等分离方法将溶液中游离药物和脂质体分离，分别测定，计算包封率。通常要求脂质体的药物包封率达80%以上。</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">载药量：载药量＝[脂质体中药物量/（脂质体中药物＋载体总量）]×％</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">载药量的大小直接影响到药物的临床应用剂量，故载药量愈大，愈易满足临床需要。载药量与药物的性质有关，通常亲脂性药物或亲水性药物较易制成脂质体。</p><h4 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; font-size: 18px;"><span class="prefix" style="display: none;"></span><span class="content">脂质体的稳定性</span><span class="suffix" style="display: none;"></span></h4><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">1、物理稳定性:主要用渗漏率表示。</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">渗漏率＝（放置前介质中药物量－放置后介质中的药量）/制剂中药量x%</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">弹固醇以加固脂质双分子层膜，降低膜流动，可减小渗漏率。</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">2、化学稳定性：</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">(1)磷脂氧化指数：氧化指数＝A233nm=A215nm；一般规定磷脂氧化指数应小于0.2。</p><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">(2)磷脂量的测定：基于每个磷脂分子中仅含1个磷原素，采用化学法将样品中磷脂转变为无机磷后测定磷摩尔量（或重量），即可推出磷脂量。</p><h4 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; font-size: 18px;"><span class="prefix" style="display: none;"></span><span class="content">防止氧化的措施</span><span class="suffix" style="display: none;"></span></h4><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">防止氧化的一般措施有充入氮气，添加抗氧剂-生育酚、金属络合剂等；也可直接采用氢化饱和磷脂。</p><h4 data-tool="mdnice编辑器" style="margin-top: 30px; margin-bottom: 15px; padding: 0px; font-size: 18px;"><span class="prefix" style="display: none;"></span><span class="content">脂质体的灭菌</span><span class="suffix" style="display: none;"></span></h4><p data-tool="mdnice编辑器" style="padding-top: 8px; padding-bottom: 8px; margin: 10px; line-height: 1.75; letter-spacing: 0.2em; font-size: 15px; word-spacing: 0.1em;">灭菌的一般方法有过滤除菌、无菌操作、－射线照射（60钴15～20kGy）、121℃热压灭菌等</p></section><p><br/></p> </div> <div class="solicit"> <div class="solicit-item"> <b>全年征稿/资讯合作</b> <span>联系邮箱：137230772@qq.com</span> </div> </div> <div class="coprt"> <div class="title"><i></i><span>版权与免责声明</span><i></i></div> <div class="content"> <p>1、凡本网注明"来源：化工机械设备网"的所有作品，版权均属于化工机械设备网，转载请必须注明化工机械设备网，https://www.huajx.com/。违反者本网将追究相关法律责任。</p> <p>2、企业发布的公司新闻、技术文章、资料下载等内容，如涉及侵权、违规遭投诉的，一律由发布企业自行承担责任，本网有权删除内容并追溯责任。</p> <p>3、本网转载并注明自其它来源的作品，目的在于传递更多信息，并不代表本网赞同其观点或证实其内容的真实性，不承担此类作品侵权行为的直接责任及连带责任。其他媒体、网站或个人从本网转载时，必须保留本网注明的作品来源，并自负版权等法律责任。</p> <p>4、如涉及作品内容、版权等问题，请在作品发表之日起一周内与本网联系，否则视为放弃相关权利。</p> </div> </div> </div> </div> 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