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Our previous findings proved that a poly herbal formulation, Le Pana Guliya (LPG) has beneficial potential as an" /> <title>(PDF) A Traditional Poly Herbal Drug Induced Apoptosis via Caspase 3 Mediated Pathway in RD Cells but Caspase 3 Independent Pathway in MCF-7 Cells | Innovationinfo Publishing - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/38031688/A_Traditional_Poly_Herbal_Drug_Induced_Apoptosis_via_Caspase_3_Mediated_Pathway_in_RD_Cells_but_Caspase_3_Independent_Pathway_in_MCF_7_Cells" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732365411000); window.Aedu.timeDifference = new Date().getTime() - 1732365411000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Research on anticancer drugs focuses on agents that induce cell death in cancer cells leaving healthy cells unaffected. Our previous findings proved that a poly herbal formulation, Le Pana Guliya (LPG) has beneficial potential as an anti-proliferative and anticancer agent. The aim of the study is to evaluate anticancer activity of LPG against Human Rhabdomyosarcoma (RD) and human breast adenocarcinoma (MCF- 7) cells. This study focused on the death of cancer cells induced by LPG with minimum effects on healthy CC1 and to evaluate molecular mechanisms. The levels of GSH, NO, and caspase, DNA fragmentation and changes in morphology characteristic to apoptosis were investigated after treatment with LPG in RD and MCF-7 cancer cells. The results were compared with CC1 cells. A significant dose dependent decrease in protein synthesis and increase in NO levels were observed in both cancer cell types compared to CC1 cells. The reduction of GSH content and elevation of cell survival with exogenous GSH proved that the LPG caused cell death via induction of oxidative stress. Increase in caspase activity and DNA fragmentation were observed only in RD cells. The MCF-7 cells did not show any features of apoptosis. Thus, the present study provides evidence for that LPG stimulates oxidative stress by decreasing the levels of cellular total GSH levels and depletion of MMP in RD cells which in turn switching on the caspase cascade leads to apoptosis. Furthermore, the results reflect that MCF- 7 induces cell death in caspase independent pathway and less toxicity against CC1 cells by LPG.","author":[{"@context":"https://schema.org","@type":"Person","name":"Innovationinfo Publishing"}],"contributor":[],"dateCreated":"2018-12-23","dateModified":"2018-12-23","datePublished":"2018-10-24","headline":"A Traditional Poly Herbal Drug Induced Apoptosis via Caspase 3 Mediated Pathway in RD Cells but Caspase 3 Independent Pathway in MCF-7 Cells","inLanguage":"en","keywords":["Apoptosis","DNA fragmentation"],"locationCreated":null,"publication":"Asian Journal of Ethnopharmacology and Medicinal Foods","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/38031688/A_Traditional_Poly_Herbal_Drug_Induced_Apoptosis_via_Caspase_3_Mediated_Pathway_in_RD_Cells_but_Caspase_3_Independent_Pathway_in_MCF_7_Cells","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F38031688%2FA_Traditional_Poly_Herbal_Drug_Induced_Apoptosis_via_Caspase_3_Mediated_Pathway_in_RD_Cells_but_Caspase_3_Independent_Pathway_in_MCF_7_Cells%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":58053998,"identifier":"Attachment_58053998","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":38031688,"created_at":"2018-12-23T23:13:39.213-08:00","from_world_paper_id":null,"updated_at":"2021-01-16T01:42:17.140-08:00","_data":{"issue":"3","volume":"4","abstract":"Research on anticancer drugs focuses on agents that induce cell\ndeath in cancer cells leaving healthy cells unaffected. Our previous\nfindings proved that a poly herbal formulation, Le Pana Guliya (LPG) has\nbeneficial potential as an anti-proliferative and anticancer agent. The\naim of the study is to evaluate anticancer activity of LPG against Human\nRhabdomyosarcoma (RD) and human breast adenocarcinoma (MCF-\n7) cells. This study focused on the death of cancer cells induced by\nLPG with minimum effects on healthy CC1 and to evaluate molecular\nmechanisms.\nThe levels of GSH, NO, and caspase, DNA fragmentation and\nchanges in morphology characteristic to apoptosis were investigated\nafter treatment with LPG in RD and MCF-7 cancer cells. The results\nwere compared with CC1 cells. A significant dose dependent decrease\nin protein synthesis and increase in NO levels were observed in both\ncancer cell types compared to CC1 cells. The reduction of GSH content\nand elevation of cell survival with exogenous GSH proved that the\nLPG caused cell death via induction of oxidative stress. Increase in\ncaspase activity and DNA fragmentation were observed only in RD cells.\nThe MCF-7 cells did not show any features of apoptosis.\nThus, the present study provides evidence for that LPG stimulates\noxidative stress by decreasing the levels of cellular total GSH levels and\ndepletion of MMP in RD cells which in turn switching on the caspase\ncascade leads to apoptosis. Furthermore, the results reflect that MCF-\n7 induces cell death in caspase independent pathway and less toxicity\nagainst CC1 cells by LPG.","more_info":"Citation: Wageesha NDA, Soysa P, Attanayake K, Choudhary MI, Ekanayake M (2018) A Traditional Poly Herbal Drug Induced Apoptosis via Caspase 3 Mediated Pathway in rd Cells but Caspase 3 Independent Pathway in mcf-7 Cells. Asian Journal of Ethnopharmacology and Medicinal Foods Vol: 4, Issu: 3 (26-34).","journal_name":"Asian Journal of Ethnopharmacology and Medicinal Foods","page_numbers":"26-34","publication_date":"2018,10,24","publication_name":"Asian Journal of Ethnopharmacology and Medicinal Foods"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"A Traditional Poly Herbal Drug Induced Apoptosis via Caspase 3 Mediated Pathway in RD Cells but Caspase 3 Independent Pathway in MCF-7 Cells","broadcastable":true,"draft":false,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [95758512]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":58053998,"attachmentType":"pdf"}"><img alt="First page of “A Traditional Poly Herbal Drug Induced Apoptosis via Caspase 3 Mediated Pathway in RD Cells but Caspase 3 Independent Pathway in MCF-7 Cells”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/58053998/mini_magick20181223-13622-qiiu3.png?1545636310" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">A Traditional Poly Herbal Drug Induced Apoptosis via Caspase 3 Mediated Pathway in RD Cells but Caspase 3 Independent Pathway in MCF-7 Cells</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="95758512" href="https://independent.academia.edu/InnovationInfo"><img alt="Profile image of Innovationinfo Publishing" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/95758512/20971427/20815640/s65_innovationinfo.publishing.jpg" />Innovationinfo Publishing</a></div><p class="ds-work-card--detail ds2-5-body-sm">2018, Asian Journal of Ethnopharmacology and Medicinal Foods</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Research on anticancer drugs focuses on agents that induce cell death in cancer cells leaving healthy cells unaffected. Our previous findings proved that a poly herbal formulation, Le Pana Guliya (LPG) has beneficial potential as an anti-proliferative and anticancer agent. The aim of the study is to evaluate anticancer activity of LPG against Human Rhabdomyosarcoma (RD) and human breast adenocarcinoma (MCF- 7) cells. This study focused on the death of cancer cells induced by LPG with minimum effects on healthy CC1 and to evaluate molecular mechanisms. The levels of GSH, NO, and caspase, DNA fragmentation and changes in morphology characteristic to apoptosis were investigated after treatment with LPG in RD and MCF-7 cancer cells. The results were compared with CC1 cells. A significant dose dependent decrease in protein synthesis and increase in NO levels were observed in both cancer cell types compared to CC1 cells. The reduction of GSH content and elevation of cell survival with exogenous GSH proved that the LPG caused cell death via induction of oxidative stress. Increase in caspase activity and DNA fragmentation were observed only in RD cells. The MCF-7 cells did not show any features of apoptosis. Thus, the present study provides evidence for that LPG stimulates oxidative stress by decreasing the levels of cellular total GSH levels and depletion of MMP in RD cells which in turn switching on the caspase cascade leads to apoptosis. Furthermore, the results reflect that MCF- 7 induces cell death in caspase independent pathway and less toxicity against CC1 cells by LPG.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":58053998,"attachmentType":"pdf","workUrl":"https://www.academia.edu/38031688/A_Traditional_Poly_Herbal_Drug_Induced_Apoptosis_via_Caspase_3_Mediated_Pathway_in_RD_Cells_but_Caspase_3_Independent_Pathway_in_MCF_7_Cells"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":58053998,"attachmentType":"pdf","workUrl":"https://www.academia.edu/38031688/A_Traditional_Poly_Herbal_Drug_Induced_Apoptosis_via_Caspase_3_Mediated_Pathway_in_RD_Cells_but_Caspase_3_Independent_Pathway_in_MCF_7_Cells"}"><span class="material-symbols-outlined" style="font-size: 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data-collection-position="5" data-entity-id="65716197" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/65716197/APOPTOSIS_OF_MCF_7_CANCER_CELL_INDUCED_BY_POMEGRANATE_Punica_granatum_L_PEEL_EXTRACT">APOPTOSIS OF MCF-7 CANCER CELL INDUCED BY POMEGRANATE ( Punica granatum L . ) PEEL EXTRACT</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="25373877" href="https://independent.academia.edu/jinnawatmanasathien">jinnawat manasathien</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Various aspects of pomegranate (Punica granatum Linn.) have been documented in traditional medicine. In the present study, pomegranate peel ethanolic extract (PPE) was investigated for many aspects relating to the caspase-3-deficient human breast cancer cell line (MCF-7), especially on the antiproliferative effects, morphological changes, DNA fragmentation, and apoptotic molecule-activated cell death. The results showed that PPE could inhibit the proliferation of MCF-7 cells in a doseand time-dependent manner. PPE has a strongly positive influence on antiproliferation and apoptotic induction of MCF-7 cells, as seen via morphological changes and oligonucleosomal DNA fragments. Apoptosis was accompanied by bcl-2, caspase-9, caspase-7, and poly (ADP-ribose) polymerase (PARP) levels. PPE induced apoptosis indicating that there was a reduction of bcl-2, procaspase-9, and procaspase-7 activities, but it activated the PARP activity. Moreover, these protein levels were associated with morph...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"APOPTOSIS OF MCF-7 CANCER CELL INDUCED BY POMEGRANATE ( Punica granatum L . ) PEEL EXTRACT","attachmentId":77191728,"attachmentType":"pdf","work_url":"https://www.academia.edu/65716197/APOPTOSIS_OF_MCF_7_CANCER_CELL_INDUCED_BY_POMEGRANATE_Punica_granatum_L_PEEL_EXTRACT","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/65716197/APOPTOSIS_OF_MCF_7_CANCER_CELL_INDUCED_BY_POMEGRANATE_Punica_granatum_L_PEEL_EXTRACT"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="16635667" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16635667/A_Comparative_Study_of_Apoptosis_and_Necrosis_in_HepG2_Cells_Oxidant_Induced_Caspase_Inactivation_Leads_to_Necrosis">A Comparative Study of Apoptosis and Necrosis in HepG2 Cells: Oxidant-Induced Caspase Inactivation Leads to Necrosis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35986072" href="https://dahphd.academia.edu/AfshinSamali">Afshin Samali</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38328559" href="https://independent.academia.edu/SOrrenius">S. Orrenius</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical and Biophysical Research Communications, 1999</p><p class="ds-related-work--abstract ds2-5-body-sm">Apoptosis and necrosis are two distinct forms of cell death that can occur in response to various agents. In the present study the HepG2 cell line was used for a comparative study of CD95-mediated apoptosis and menadione-induced necrosis. Apoptosis coincided with the release of cytochrome c from mitochondria, activation of caspases, cleavage of cellular proteins, and also involved nuclear condensation and DNA fragmentation. Necrosis was not accompanied by DNA fragmentation, caspase activation or cleavage of caspase target proteins, despite cytochrome c release from mitochondria. In fact, the addition of menadione to cells undergoing CD95-mediated apoptosis blocked their caspase activity. Inhibition of caspases coincided with an accumulation of reactive oxygen species (ROS) and ATP depletion. In order to determine the predominance of either of these events in the inhibition of caspase, cells were either co-incubated with antioxidant enzymes or their ATP level was manipulated to maintain it at a relatively high level during the experiments. Co-incubation with catalase, but not Cu/Zn superoxide dismutase, substantially reduced the levels of ROS and reversed the inhibitory effect of menadione on caspase activity. In contrast, increasing cellular ATP level had little effect on restoring caspase activity. These data suggest that menadione inhibits caspase activity by the generation of hydrogen peroxide through redox cycling and that caspase inactivation by this mechanism may prevent cell death by apoptosis in this oxidative-stress model.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Comparative Study of Apoptosis and Necrosis in HepG2 Cells: Oxidant-Induced Caspase Inactivation Leads to Necrosis","attachmentId":42423328,"attachmentType":"pdf","work_url":"https://www.academia.edu/16635667/A_Comparative_Study_of_Apoptosis_and_Necrosis_in_HepG2_Cells_Oxidant_Induced_Caspase_Inactivation_Leads_to_Necrosis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16635667/A_Comparative_Study_of_Apoptosis_and_Necrosis_in_HepG2_Cells_Oxidant_Induced_Caspase_Inactivation_Leads_to_Necrosis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="34577528" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/34577528/A_New_Alternative_Medicine_can_cause_Selective_Cell_Death_in_Cancer_Cells_Principle_investigator">A New Alternative Medicine can cause Selective Cell Death in Cancer Cells Principle investigator</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="21459355" href="https://independent.academia.edu/MogeebKabashi">Mogeeb Kabashi</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A New Alternative Medicine can cause Selective Cell Death in Cancer Cells Principle investigator","attachmentId":54443386,"attachmentType":"pdf","work_url":"https://www.academia.edu/34577528/A_New_Alternative_Medicine_can_cause_Selective_Cell_Death_in_Cancer_Cells_Principle_investigator","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/34577528/A_New_Alternative_Medicine_can_cause_Selective_Cell_Death_in_Cancer_Cells_Principle_investigator"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="17906347" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17906347/Phloroglucinol_derivative_MCPP_induces_cell_apoptosis_in_human_colon_cancer">Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37822776" href="https://independent.academia.edu/KarlokWong">Kar-lok Wong</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Cellular Biochemistry, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">This study is the first to investigate the anticancer effects of the new phloroglucinol derivative (3,6-bis(3-chlorophenylacetyl)phloroglucinol; MCPP) in human colon cancer cells. MCPP induced cell death and antiproliferation in three human colon cancer, HCT-116, SW480, and Caco-2 cells, but not in primary human dermal fibroblast cells. MCPP-induced concentration-dependent apoptotic cell death in colon cancer cells was measured by fluorescence-activated cell sorter (FACS) analysis. Treatment of HCT-116 human colon cancer cells with MCPP was found to induce a number of signature endoplasmic reticulum (ER) stress markers; and up-regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) and glucose-regulated protein (GRP)-78, phosphorylation of eukaryotic initiation factor-2α (eIF-2α), suggesting the induction of ER stress. MCPP also increased GSK3α/β(Tyr270/216) phosphorylation and reduced GSK3α/β(Ser21/9) phosphorylation time-dependently. Transfection of cells with GRP78 or CHOP siRNA, or treatment of GSK3 inhibitor SB216163 reduced MCPP-mediated cell apoptosis. Treatment of MCPP also increased caspase-7, caspase-9, and caspase-3 activity. The inhibition of caspase activity by z-DEVE-FMK or z-VAD-FMK significantly reduced MCPP-induced apoptosis. Furthermore, treatment of GSK3 inhibitor SB216763 also dramatically reversed MCPP-induced GRP and CHOP up-regulation, and pro-caspase-3 and pro-caspase-9 degradation. Taken together, the present study provides evidences to support that GRP78 and CHOP expression, and GSK3α/β activation in mediating the MCPP-induced human colon cancer cell apoptosis.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer","attachmentId":42218619,"attachmentType":"pdf","work_url":"https://www.academia.edu/17906347/Phloroglucinol_derivative_MCPP_induces_cell_apoptosis_in_human_colon_cancer","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17906347/Phloroglucinol_derivative_MCPP_induces_cell_apoptosis_in_human_colon_cancer"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="85118936" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85118936/6_8_Dihydroxy_7_methoxy_1_methyl_azafluorenone_Induces_Caspase_8_and_9_mediated_Apoptosis_in_Human_Cancer_Cells">6,8-Dihydroxy-7-methoxy-1-methyl-azafluorenone Induces Caspase-8- and -9-mediated Apoptosis in Human Cancer Cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="180394947" href="https://independent.academia.edu/WilartPompimon">Wilart Pompimon</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Asian Pacific Journal of Cancer Prevention, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"6,8-Dihydroxy-7-methoxy-1-methyl-azafluorenone Induces Caspase-8- and -9-mediated Apoptosis in Human Cancer Cells","attachmentId":89917949,"attachmentType":"pdf","work_url":"https://www.academia.edu/85118936/6_8_Dihydroxy_7_methoxy_1_methyl_azafluorenone_Induces_Caspase_8_and_9_mediated_Apoptosis_in_Human_Cancer_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/85118936/6_8_Dihydroxy_7_methoxy_1_methyl_azafluorenone_Induces_Caspase_8_and_9_mediated_Apoptosis_in_Human_Cancer_Cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":58053998,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":58053998,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_58053998" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="15467031" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15467031/5_7_3_trihydroxy_3_4_dimethoxyflavone_induced_cell_death_in_human_Leukemia_cells_is_dependent_on_caspases_and_activates_the_MAPK_pathway">5,7,3′-trihydroxy-3,4′-dimethoxyflavone-induced cell death in human Leukemia cells is dependent on caspases and activates the MAPK pathway</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34611831" href="https://independent.academia.edu/FernandoTorres87">Fernando Torres</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular Carcinogenesis, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"5,7,3′-trihydroxy-3,4′-dimethoxyflavone-induced cell death in human Leukemia cells is dependent on caspases and activates the MAPK pathway","attachmentId":43171114,"attachmentType":"pdf","work_url":"https://www.academia.edu/15467031/5_7_3_trihydroxy_3_4_dimethoxyflavone_induced_cell_death_in_human_Leukemia_cells_is_dependent_on_caspases_and_activates_the_MAPK_pathway","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15467031/5_7_3_trihydroxy_3_4_dimethoxyflavone_induced_cell_death_in_human_Leukemia_cells_is_dependent_on_caspases_and_activates_the_MAPK_pathway"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="13143684" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13143684/Activation_of_caspase_3_dependent_and_independent_pathways_during_7_ketocholesterol_and_7%CE%B2_hydroxycholesterol_induced_cell_death_A_morphological_and_biochemical_study">Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7β-hydroxycholesterol-induced cell death: A morphological and biochemical study</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32397483" href="https://inserm.academia.edu/G%C3%A9rardLizard">Gérard Lizard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biochemical and Molecular Toxicology, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7β-hydroxycholesterol-induced cell death: A morphological and biochemical study","attachmentId":45699907,"attachmentType":"pdf","work_url":"https://www.academia.edu/13143684/Activation_of_caspase_3_dependent_and_independent_pathways_during_7_ketocholesterol_and_7%CE%B2_hydroxycholesterol_induced_cell_death_A_morphological_and_biochemical_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/13143684/Activation_of_caspase_3_dependent_and_independent_pathways_during_7_ketocholesterol_and_7%CE%B2_hydroxycholesterol_induced_cell_death_A_morphological_and_biochemical_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="31576458" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31576458/Ethyl_Alcohol_Extract_of_Hizikia_fusiforme_Induces_Caspase_dependent_Apoptosis_in_Human_Leukemia_U937_Cells_by_Generation_of_Reactive_Oxygen_Species">Ethyl Alcohol Extract of Hizikia fusiforme Induces Caspase-dependent Apoptosis in Human Leukemia U937 Cells by Generation of Reactive Oxygen Species</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43017401" href="https://konkuk.academia.edu/SungjinPark">Sungjin Park</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Ethyl Alcohol Extract of Hizikia fusiforme Induces Caspase-dependent Apoptosis in Human Leukemia U937 Cells by Generation of Reactive Oxygen Species","attachmentId":51910139,"attachmentType":"pdf","work_url":"https://www.academia.edu/31576458/Ethyl_Alcohol_Extract_of_Hizikia_fusiforme_Induces_Caspase_dependent_Apoptosis_in_Human_Leukemia_U937_Cells_by_Generation_of_Reactive_Oxygen_Species","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/31576458/Ethyl_Alcohol_Extract_of_Hizikia_fusiforme_Induces_Caspase_dependent_Apoptosis_in_Human_Leukemia_U937_Cells_by_Generation_of_Reactive_Oxygen_Species"><span class="ds2-5-text-link__content">View 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DC induces cell death and apoptosis by down‐regulating the NF‐κB pathway in MCF ‐7 breast cancer cells: In vitro and in vivo investigations</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="274103507" href="https://independent.academia.edu/SONALIKAMBLE55">SONALI KAMBLE</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer Reports, 2022</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Chloroxylon swietenia (Roxb.) DC induces cell death and apoptosis by down‐regulating the NF‐κB pathway in MCF ‐7 breast cancer cells: In vitro and in vivo investigations","attachmentId":103491939,"attachmentType":"pdf","work_url":"https://www.academia.edu/103501407/Chloroxylon_swietenia_Roxb_DC_induces_cell_death_and_apoptosis_by_down_regulating_the_NF_%CE%BAB_pathway_in_MCF_7_breast_cancer_cells_In_vitro_and_in_vivo_investigations","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/103501407/Chloroxylon_swietenia_Roxb_DC_induces_cell_death_and_apoptosis_by_down_regulating_the_NF_%CE%BAB_pathway_in_MCF_7_breast_cancer_cells_In_vitro_and_in_vivo_investigations"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" 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Development and Therapy, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"\u0026alpha;-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-\u0026kappa;B and Hsp70 protein modulation in vitro, and tumor reduction in vivo","attachmentId":46545980,"attachmentType":"pdf","work_url":"https://www.academia.edu/11750051/_and_alpha_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_and_kappa_B_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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href="https://www.academia.edu/103264721/Synergistic_Apoptosis_of_CML_Cells_by_Buthionine_Sulfoximine_and_Hydroxychavicol_Correlates_with_Activation_of_AIF_and_GSH_ROS_JNK_ERK_iNOS_Pathway">Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="273483692" href="https://independent.academia.edu/anirbanmanna13">anirban manna</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLoS ONE, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS 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