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<!doctype html> <html lang="ja"> <head> <title>Antiepileptic Medication Use in Kidney and Liver Disorders | 98521</title> <meta name="keywords" content="Marjani Samyar, "/> <meta name="description" content="The challenge of reproducing tests has received a lot of attention. Problems with replication arise for a range of causes ranging from experimental design ..98521"/> <meta name="citation_publisher" content="ロングダム出版SL" /> <meta name="citation_journal_title" content="薬物代謝と毒性学ジャーナル"> <meta name="citation_title" content="Antiepileptic Medication Use in Kidney and Liver Disorders"> <meta name="citation_author" content="Marjani Samyar" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="14"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="The challenge of reproducing tests has received a lot of attention. Problems with replication arise for a range of causes ranging from experimental design to laboratory mistakes to inadequate statistical analysis. Here, we go through a number of recommendations for the design, statistical analysis, and execution of toxicological investigations. In general, hypothesisdriven trials with sufficient sample sizes, randomization, and blind data collecting methods can increase replication. Both publicly and privately within the scientific community, science is going through a kind of crisis of faith. Some high-profile cases of fraud have garnered public attention, including the debunked Stimulus-Triggered Acquisition of Pluripotency (STAP) method for STEM cells. The practicing scientist sees retractions of articles much too frequently because of shady data and methods. Although it is regrettable, grant review panels, reviewers, editors, and observant readers at least seem to be able to spot fraud. More harmful are the claims that have surfaced in recent years about publications across several fields having poor replication records, with no proof of fraud. According to a recent article in Science, less than half of psychological studies could be repeated. Although it seems reasonable that the "soft sciences" should not replicate well, the biological sciences also perform badly when replication pressure is applied to them. According to reports from the pharmaceutical industry, failure rates for attempts to reproduce published studies to progress medication development are considerably over 50%. 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challenge of reproducing tests has received a lot of attention. Problems with replication arise for a range of causes ranging from experimental design to laboratory mistakes to inadequate statistical analysis. Here, we go through a number of recommendations for the design, statistical analysis, and execution of toxicological investigations. In general, hypothesisdriven trials with sufficient sample sizes, randomization, and blind data collecting methods can increase replication. Both publicly and privately within the scientific community, science is going through a kind of crisis of faith. Some high-profile cases of fraud have garnered public attention, including the debunked Stimulus-Triggered Acquisition of Pluripotency (STAP) method for STEM cells. The practicing scientist sees retractions of articles much too frequently because of shady data and methods. Although it is regrettable, grant review panels, reviewers, editors, and observant readers at least seem to be able to spot fraud. More harmful are the claims that have surfaced in recent years about publications across several fields having poor replication records, with no proof of fraud. According to a recent article in Science, less than half of psychological studies could be repeated. Although it seems reasonable that the "soft sciences" should not replicate well, the biological sciences also perform badly when replication pressure is applied to them. According to reports from the pharmaceutical industry, failure rates for attempts to reproduce published studies to progress medication development are considerably over 50%.</p> <div class="alert alert-info text-left"><b>免責事項:</b> この要約は人工知能ツールを使用して翻訳されたものであり、まだレビューまたは検証されていません。</div> <div class="nav social-icons"> <a class="nav-link w-auto">この記事をシェアする</a> <a title="ここをクリック" target="_blank" href="https://www.facebook.com/sharer.php?u=https://japanese.longdom.org/abstract/antiepileptic-medication-use-in-kidney-and-liver-disorders-98521.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="ここをクリック" target="_blank" href="https://twitter.com/share?url=https://japanese.longdom.org/abstract/antiepileptic-medication-use-in-kidney-and-liver-disorders-98521.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="ここをクリック" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://japanese.longdom.org/abstract/antiepileptic-medication-use-in-kidney-and-liver-disorders-98521.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="ここをクリック" target="_blank" href="https://plus.google.com/share?url=https://japanese.longdom.org/abstract/antiepileptic-medication-use-in-kidney-and-liver-disorders-98521.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">コンテンツリンク</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://japanese.longdom.org/privacy-policy.html" title="ここをクリック">プライバシーポリシー</a></li> <li><a class="" href="https://japanese.longdom.org/terms-conditions.html" title="ここをクリック">利用規約</a></li> <li><a class="" href="https://japanese.longdom.org/authors-reviewers-editors.html" title="ここをクリック">著者、査読者、編集者</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">ロングダムに連絡する</h4> <p><strong>ロングダムグループ SA</strong><br /> ロジェ・ヴァンデンドリッシュ通り、<br /> 18、1150 ブリュッセル、ベルギー<br /> 電話番号: +442038085340<br /> <strong>メール:</strong> <a class="white" href="mailto:info@longdom.org" title="ここをクリック">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">接続</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="ここをクリック" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="ここをクリック" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="ここをクリック" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="ここをクリック" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>著作権 © 2024 <a href="https://japanese.longdom.org/" title="ここをクリック" class="white">ロングダム出版SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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